Under-expression is coded with green,
over-expression with red color.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
vasculature development
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure.
heart looping
The characteristic morphogenetic movements where the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration.
morphogenesis of an epithelium
The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
regulation of the force of heart contraction
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
heart morphogenesis
The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
system process
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
skeletal muscle contraction
A process whereby force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.
muscle system process
A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
circulatory system process
A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
heart process
A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
embryonic heart tube morphogenesis
The process by which the anatomical structures of the embryonic heart tube are generated and organized. Morphogenesis pertains to the creation of form. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
cardiac chamber development
The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.
cardiac chamber morphogenesis
The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
cardiac chamber formation
The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.
cardiac ventricle morphogenesis
The process by which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
cardiac atrium morphogenesis
The process by which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
cardiac ventricle formation
The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
ventricular cardiac muscle tissue development
The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.
cardiac atrium development
The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
cardiac ventricle development
The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
muscle contraction
A process whereby force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
actin cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
generation of precursor metabolites and energy
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of nucleotide metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
purine nucleotide metabolic process
The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
purine nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
nucleoside phosphate metabolic process
The chemical reactions and pathways involving any phosphorylated nucleoside.
nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
transport
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.
cellular ion homeostasis
Any process involved in the maintenance of an internal steady-state of ions at the level of a cell.
regulation of muscle contraction
Any process that modulates the frequency, rate or extent of muscle contraction.
striated muscle contraction
A process whereby force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
regulation of striated muscle contraction
Any process that modulates the frequency, rate or extent of striated muscle contraction.
organelle organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
embryo development
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
organ morphogenesis
Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
sensory organ development
The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.
heart development
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
adult heart development
The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure.
muscle organ development
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
blood circulation
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
regulation of heart contraction
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
actin filament-based movement
Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.
catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
nucleotide metabolic process
The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).
nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
regulation of catabolic process
Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
cardioblast differentiation
The process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
cellular component assembly
The aggregation, arrangement and bonding together of a cellular component.
anatomical structure formation involved in morphogenesis
The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
cellular component assembly involved in morphogenesis
The cellular component assembly that is part of the initial shaping of the component during its developmental progression.
striated muscle tissue development
The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.
skeletal myofibril assembly
The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.
cellular component organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
cellular homeostasis
Any process involved in the maintenance of an internal steady-state at the level of the cell.
actin filament-based process
Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
muscle filament sliding
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
cell differentiation
The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
myofibril assembly
Formation of myofibrils, the repeating units of striated muscle.
cytoskeleton-dependent intracellular transport
The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.
regulation of nucleotide catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.
actomyosin structure organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
regulation of cellular catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
positive regulation of ATPase activity
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
regulation of localization
Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
cellular component morphogenesis
The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.
regulation of purine nucleotide catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.
actin-myosin filament sliding
The sliding movement of actin thin filaments and myosin thick filaments past each other.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
nucleobase, nucleoside and nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides and nucleotides.
embryonic heart tube development
The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.
cardiac cell differentiation
The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.
tube morphogenesis
The process by which the anatomical structures of a tube are generated and organized. Morphogenesis pertains to the creation of form. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
tube development
The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
ear morphogenesis
The process by which the anatomical structures of the ear are generated and organized. Morphogenesis pertains to the creation of form. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.
homeostatic process
Any biological process involved in the maintenance of an internal steady-state.
muscle cell differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell.
extracellular structure organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.
positive regulation of catalytic activity
Any process that activates or increases the activity of an enzyme.
regulation of ATPase activity
Any process that modulates the rate of ATP hydrolysis by an ATPase.
ear development
The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.
regulation of system process
Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
cellular component biogenesis
The process by which a cellular component is synthesized, aggregates, and bonds together. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.
positive regulation of molecular function
Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular nitrogen compound catabolic process
The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds.
small molecule metabolic process
The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
sarcomere organization
The myofibril assembly process by which the muscle actomyosin is organized into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
fat cell differentiation
The process whereby a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
regulation of cell differentiation
Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.
positive regulation of cell differentiation
Any process that activates or increases the frequency, rate or extent of cell differentiation.
heterocycle metabolic process
The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
heterocycle catabolic process
The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
muscle cell homeostasis
The cellular homeostatic process by which a muscle cell is preserved in a stable functional or structural state.
intracellular transport
The directed movement of substances within a cell.
ion homeostasis
Any process involved in the maintenance of an internal steady-state of ions within an organism or cell.
cell development
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
embryonic organ morphogenesis
Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
embryonic organ development
Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
embryonic morphogenesis
The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
tissue morphogenesis
The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
cardiac muscle tissue development
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
chemical homeostasis
Any biological process involved in the maintenance of an internal steady-state of a chemical.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of catalytic activity
Any process that modulates the activity of an enzyme.
regulation of developmental process
Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
brown fat cell differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
multicellular organismal movement
Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism.
musculoskeletal movement
The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.
positive regulation of developmental process
Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
striated muscle cell differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.
regulation of muscle cell differentiation
Any process that modulates the frequency, rate or extent of muscle cell differentiation.
regulation of nitrogen compound metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
localization
Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
regulation of hydrolase activity
Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
positive regulation of hydrolase activity
Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.
cellular localization
Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
establishment of localization in cell
The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
regulation of cardioblast differentiation
Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
positive regulation of cardioblast differentiation
Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
muscle cell development
The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
striated muscle cell development
The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.
cardiac myofibril assembly
The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.
cardiac cell development
The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual.
cardiac muscle cell differentiation
The process whereby a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.
ventricular cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac ventricle muscle is generated and organized. Morphogenesis pertains to the creation of form.
cardiac muscle cell development
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
cellular chemical homeostasis
Any biological process involved in the maintenance of an internal steady-state of a chemical at the level of the cell.
nucleobase, nucleoside and nucleotide metabolic process
The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.
heart contraction
The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.
cardiac muscle contraction
Muscle contraction of cardiac muscle tissue.
anatomical structure homeostasis
A homeostatic process involved in the maintenance of an internal steady-state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
trabecula formation
The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.
muscle tissue morphogenesis
The process by which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. Morphogenesis pertains to the creation of form.
epithelium development
The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
muscle tissue development
The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.
epithelial tube morphogenesis
The process by which the anatomical structures of a tube are generated and organized from an epithelium. Morphogenesis pertains to the creation of form. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
muscle structure development
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
regulation of biological quality
Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
regulation of molecular function
Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
actin-mediated cell contraction
The actin filament-based process by which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.
regulation of primary metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
regulation of muscle system process
Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.
regulation of multicellular organismal development
Any process that modulates the frequency, rate or extent of multicellular organismal development.
all
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cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
organelle organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
extracellular structure organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
cellular component assembly
The aggregation, arrangement and bonding together of a cellular component.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
positive regulation of developmental process
Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of developmental process
Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
regulation of localization
Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
cellular localization
Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of catabolic process
Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.
regulation of nitrogen compound metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
regulation of primary metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
cellular component morphogenesis
The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
establishment of localization in cell
The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
cellular component assembly involved in morphogenesis
The cellular component assembly that is part of the initial shaping of the component during its developmental progression.
embryo development
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
regulation of system process
Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
regulation of multicellular organismal development
Any process that modulates the frequency, rate or extent of multicellular organismal development.
anatomical structure formation involved in morphogenesis
The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
cellular component morphogenesis
The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.
embryonic morphogenesis
The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
cellular component assembly involved in morphogenesis
The cellular component assembly that is part of the initial shaping of the component during its developmental progression.
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
tube development
The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
cell development
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
regulation of cell differentiation
Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.
positive regulation of developmental process
Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of multicellular organismal development
Any process that modulates the frequency, rate or extent of multicellular organismal development.
positive regulation of cell differentiation
Any process that activates or increases the frequency, rate or extent of cell differentiation.
intracellular transport
The directed movement of substances within a cell.
regulation of catalytic activity
Any process that modulates the activity of an enzyme.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of cellular catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular nitrogen compound catabolic process
The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of cellular catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
heterocycle catabolic process
The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
nucleobase, nucleoside and nucleotide metabolic process
The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.
nucleobase, nucleoside and nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides and nucleotides.
actin cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
actin-myosin filament sliding
The sliding movement of actin thin filaments and myosin thick filaments past each other.
regulation of cell differentiation
Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.
positive regulation of cell differentiation
Any process that activates or increases the frequency, rate or extent of cell differentiation.
cell development
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
positive regulation of cell differentiation
Any process that activates or increases the frequency, rate or extent of cell differentiation.
regulation of muscle system process
Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.
embryonic heart tube development
The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.
tube morphogenesis
The process by which the anatomical structures of a tube are generated and organized. Morphogenesis pertains to the creation of form. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
regulation of cardioblast differentiation
Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
cardiac chamber formation
The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.
tissue morphogenesis
The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.
trabecula formation
The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.
embryonic organ morphogenesis
Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
embryonic heart tube morphogenesis
The process by which the anatomical structures of the embryonic heart tube are generated and organized. Morphogenesis pertains to the creation of form. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
embryonic organ morphogenesis
Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
cardiac chamber morphogenesis
The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
tissue morphogenesis
The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.
organ morphogenesis
Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
embryonic organ development
Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
muscle organ development
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
muscle cell differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell.
cellular homeostasis
Any process involved in the maintenance of an internal steady-state at the level of the cell.
positive regulation of catalytic activity
Any process that activates or increases the activity of an enzyme.
nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
positive regulation of hydrolase activity
Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.
purine nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
nucleobase, nucleoside and nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides and nucleotides.
myofibril assembly
Formation of myofibrils, the repeating units of striated muscle.
cardiac cell development
The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual.
regulation of muscle cell differentiation
Any process that modulates the frequency, rate or extent of muscle cell differentiation.
muscle cell development
The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
cardiac muscle cell development
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
positive regulation of cardioblast differentiation
Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
sarcomere organization
The myofibril assembly process by which the muscle actomyosin is organized into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
muscle filament sliding
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
regulation of muscle contraction
Any process that modulates the frequency, rate or extent of muscle contraction.
heart contraction
The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.
regulation of the force of heart contraction
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
cardiac ventricle formation
The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
embryonic heart tube morphogenesis
The process by which the anatomical structures of the embryonic heart tube are generated and organized. Morphogenesis pertains to the creation of form. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
cardiac chamber morphogenesis
The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
embryonic heart tube morphogenesis
The process by which the anatomical structures of the embryonic heart tube are generated and organized. Morphogenesis pertains to the creation of form. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
heart looping
The characteristic morphogenetic movements where the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration.
epithelial tube morphogenesis
The process by which the anatomical structures of a tube are generated and organized from an epithelium. Morphogenesis pertains to the creation of form. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.
cardiac atrium morphogenesis
The process by which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.
cardiac ventricle morphogenesis
The process by which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
morphogenesis of an epithelium
The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
heart morphogenesis
The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
cardiac chamber development
The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.
embryonic heart tube development
The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.
cardiac cell differentiation
The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.
muscle tissue development
The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.
actin filament-based movement
Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.
cellular chemical homeostasis
Any biological process involved in the maintenance of an internal steady-state of a chemical at the level of the cell.
muscle cell homeostasis
The cellular homeostatic process by which a muscle cell is preserved in a stable functional or structural state.
regulation of nucleotide catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.
regulation of purine nucleotide catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.
purine nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
regulation of nucleotide catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.
positive regulation of ATPase activity
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
regulation of nucleotide metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
purine nucleotide metabolic process
The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
regulation of cardioblast differentiation
Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
positive regulation of cardioblast differentiation
Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
cardiac muscle cell development
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
striated muscle cell development
The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.
cardiac muscle cell differentiation
The process whereby a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
myofibril assembly
Formation of myofibrils, the repeating units of striated muscle.
cardiac myofibril assembly
The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.
skeletal muscle contraction
A process whereby force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.
regulation of striated muscle contraction
Any process that modulates the frequency, rate or extent of striated muscle contraction.
regulation of heart contraction
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body.
cardiac muscle contraction
Muscle contraction of cardiac muscle tissue.
ventricular cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac ventricle muscle is generated and organized. Morphogenesis pertains to the creation of form.
cardiac muscle tissue development
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
ear morphogenesis
The process by which the anatomical structures of the ear are generated and organized. Morphogenesis pertains to the creation of form. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.
cardiac muscle cell differentiation
The process whereby a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.
cellular ion homeostasis
Any process involved in the maintenance of an internal steady-state of ions at the level of a cell.
regulation of ATPase activity
Any process that modulates the rate of ATP hydrolysis by an ATPase.
ventricular cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac ventricle muscle is generated and organized. Morphogenesis pertains to the creation of form.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
contractile fiber
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
endoplasmic reticulum
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
proteinaceous extracellular matrix
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.
basement membrane
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
extracellular space
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
cytoplasm
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum lumen
The volume enclosed by the membranes of the endoplasmic reticulum.
endoplasmic reticulum membrane
The lipid bilayer surrounding the endoplasmic reticulum.
lipid particle
Any particle of coalesced lipids in the cytoplasm of a cell. May include associated proteins.
cytoskeleton
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
muscle myosin complex
A filament of myosin found in a muscle cell of any type.
troponin complex
A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.
striated muscle thin filament
Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.
cell-cell junction
A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals.
adherens junction
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
cell-cell adherens junction
An adherens junction which connects two cells to each other.
fascia adherens
A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.
cell-substrate adherens junction
An adherens junction which connects a cell to the extracellular matrix.
focal adhesion
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
endomembrane system
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
intercalated disc
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
actin cytoskeleton
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
dystrophin-associated glycoprotein complex
A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase.
dystroglycan complex
A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.
sarcoglycan complex
A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex.
basolateral plasma membrane
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
myosin complex
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
myosin II complex
A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures.
sarcoplasm
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
sarcoplasmic reticulum
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
myofibril
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
sarcomere
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
Z disc
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
cell junction
A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
cell-substrate junction
A cell junction that forms a connection between a cell and the extracellular matrix.
extracellular matrix
A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants).
organelle membrane
The lipid bilayer surrounding an organelle.
pseudopodium
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.
A band
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
I band
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
membrane-enclosed lumen
The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
myosin filament
A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
sarcoplasmic reticulum membrane
The lipid bilayer surrounding the sarcoplasmic reticulum.
sarcoplasmic reticulum lumen
The volume enclosed by the membranes of the sarcoplasmic reticulum.
nuclear membrane-endoplasmic reticulum network
The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.
sarcolemma
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
cell projection
A prolongation or process extending from a cell, e.g. a flagellum or axon.
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
organelle lumen
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
protein complex
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.
cell-cell contact zone
Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle.
extracellular matrix part
Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants).
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
contractile fiber part
Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
intracellular organelle lumen
An organelle lumen that is part of an intracellular organelle.
anchoring junction
A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
subsynaptic reticulum
An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
all
NA
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
organelle lumen
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
organelle membrane
The lipid bilayer surrounding an organelle.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
extracellular matrix part
Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants).
intracellular organelle lumen
An organelle lumen that is part of an intracellular organelle.
troponin complex
A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
organelle membrane
The lipid bilayer surrounding an organelle.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
nuclear membrane-endoplasmic reticulum network
The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
endoplasmic reticulum membrane
The lipid bilayer surrounding the endoplasmic reticulum.
nuclear membrane-endoplasmic reticulum network
The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.
dystroglycan complex
A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.
sarcoglycan complex
A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex.
basement membrane
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
troponin complex
A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.
striated muscle thin filament
Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.
myosin complex
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
endoplasmic reticulum lumen
The volume enclosed by the membranes of the endoplasmic reticulum.
endoplasmic reticulum membrane
The lipid bilayer surrounding the endoplasmic reticulum.
troponin complex
A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.
striated muscle thin filament
Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.
A band
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
I band
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
Z disc
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
endoplasmic reticulum membrane
The lipid bilayer surrounding the endoplasmic reticulum.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
contractile fiber
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
endoplasmic reticulum
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
contractile fiber part
Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
subsynaptic reticulum
An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
dystrophin-associated glycoprotein complex
A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase.
dystroglycan complex
A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.
sarcoglycan complex
A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex.
muscle myosin complex
A filament of myosin found in a muscle cell of any type.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
sarcoplasmic reticulum
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
contractile fiber part
Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
sarcoplasmic reticulum
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
cell-substrate junction
A cell junction that forms a connection between a cell and the extracellular matrix.
sarcoplasmic reticulum membrane
The lipid bilayer surrounding the sarcoplasmic reticulum.
sarcoplasmic reticulum lumen
The volume enclosed by the membranes of the sarcoplasmic reticulum.
sarcomere
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
striated muscle thin filament
Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.
myosin complex
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
cell-cell adherens junction
An adherens junction which connects two cells to each other.
cell-substrate adherens junction
An adherens junction which connects a cell to the extracellular matrix.
fascia adherens
A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.
protein binding
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
calcium ion binding
Interacting selectively and non-covalently with calcium ions (Ca2+).
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
actin binding
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
structural molecule activity
The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.
extracellular matrix structural constituent
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
binding
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
metal ion binding
Interacting selectively and non-covalently with any metal ion.
tropomyosin binding
Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.
cytoskeletal protein binding
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
structural constituent of muscle
The action of a molecule that contributes to the structural integrity of a muscle fiber.
myosin binding
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
troponin I binding
Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex.
troponin T binding
Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex.
titin binding
Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
myosin heavy chain binding
Interacting selectively and non-covalently with a heavy chain of a myosin complex.
ion binding
Interacting selectively and non-covalently with ions, charged atoms or groups of atoms.
cation binding
Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge.
all
NA
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 05414 | 7.392e-08 | 2.046 | 15 | 72 | Dilated cardiomyopathy |
| 05410 | 3.487e-07 | 1.961 | 14 | 69 | Hypertrophic cardiomyopathy (HCM) |
| 04260 | 1.053e-05 | 1.506 | 11 | 53 | Cardiac muscle contraction |
| 04510 | 1.289e-03 | 4.575 | 15 | 161 | Focal adhesion |
| 05416 | 1.337e-02 | 1.08 | 6 | 38 | Viral myocarditis |
| 05012 | 1.813e-02 | 2.046 | 8 | 72 | Parkinson's disease |
| 05412 | 2.670e-02 | 1.705 | 7 | 60 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
ABRAactin-binding Rho activating protein (ENSG00000174429), score: 0.44 ACTC1actin, alpha, cardiac muscle 1 (ENSG00000159251), score: 0.48 ACTG2actin, gamma 2, smooth muscle, enteric (ENSG00000163017), score: 0.44 ACTN2actinin, alpha 2 (ENSG00000077522), score: 0.41 ADAMTS15ADAM metallopeptidase with thrombospondin type 1 motif, 15 (ENSG00000166106), score: 0.46 ADAMTSL4ADAMTS-like 4 (ENSG00000143382), score: 0.39 ADAMTSL5ADAMTS-like 5 (ENSG00000185761), score: 0.59 ADCY6adenylate cyclase 6 (ENSG00000174233), score: 0.41 ADIPOQadiponectin, C1Q and collagen domain containing (ENSG00000181092), score: 0.89 ALOX15arachidonate 15-lipoxygenase (ENSG00000161905), score: 0.63 ALPK2alpha-kinase 2 (ENSG00000198796), score: 0.39 ALPK3alpha-kinase 3 (ENSG00000136383), score: 0.39 ANGPTL7angiopoietin-like 7 (ENSG00000171819), score: 0.53 ANKRD1ankyrin repeat domain 1 (cardiac muscle) (ENSG00000148677), score: 0.47 APOBEC2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 (ENSG00000124701), score: 0.45 APPBP2amyloid beta precursor protein (cytoplasmic tail) binding protein 2 (ENSG00000062725), score: -0.44 AQPEPlaeverin (ENSG00000172901), score: 0.57 ARFIP2ADP-ribosylation factor interacting protein 2 (ENSG00000132254), score: -0.41 ART1ADP-ribosyltransferase 1 (ENSG00000129744), score: 0.76 ART5ADP-ribosyltransferase 5 (ENSG00000167311), score: 0.45 ASB11ankyrin repeat and SOCS box-containing 11 (ENSG00000165192), score: 0.58 ASB15ankyrin repeat and SOCS box-containing 15 (ENSG00000146809), score: 0.45 ASB16ankyrin repeat and SOCS box-containing 16 (ENSG00000161664), score: 0.48 ASB2ankyrin repeat and SOCS box-containing 2 (ENSG00000100628), score: 0.43 ASB4ankyrin repeat and SOCS box-containing 4 (ENSG00000005981), score: 0.4 ATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ENSG00000174437), score: 0.46 ATP5A1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (ENSG00000152234), score: 0.39 ATP5SLATP5S-like (ENSG00000105341), score: 0.38 AVL9AVL9 homolog (S. cerevisiase) (ENSG00000105778), score: -0.45 BCKDKbranched chain ketoacid dehydrogenase kinase (ENSG00000103507), score: 0.41 BMP10bone morphogenetic protein 10 (ENSG00000163217), score: 0.51 BRP44Lbrain protein 44-like (ENSG00000060762), score: 0.45 BVESblood vessel epicardial substance (ENSG00000112276), score: 0.51 C10orf71chromosome 10 open reading frame 71 (ENSG00000177354), score: 0.46 C13orf33chromosome 13 open reading frame 33 (ENSG00000102802), score: 0.42 C14orf180chromosome 14 open reading frame 180 (ENSG00000184601), score: 0.47 C15orf57chromosome 15 open reading frame 57 (ENSG00000128891), score: -0.44 C22orf15chromosome 22 open reading frame 15 (ENSG00000169314), score: 0.43 C6orf142chromosome 6 open reading frame 142 (ENSG00000146147), score: 0.39 C8orf42chromosome 8 open reading frame 42 (ENSG00000180190), score: -0.58 CABP5calcium binding protein 5 (ENSG00000105507), score: 0.43 CASQ2calsequestrin 2 (cardiac muscle) (ENSG00000118729), score: 0.49 CAV1caveolin 1, caveolae protein, 22kDa (ENSG00000105974), score: 0.43 CAV3caveolin 3 (ENSG00000182533), score: 0.52 CCDC141coiled-coil domain containing 141 (ENSG00000163492), score: 0.5 CCDC69coiled-coil domain containing 69 (ENSG00000198624), score: 0.41 CCDC8coiled-coil domain containing 8 (ENSG00000169515), score: 0.43 CCDC80coiled-coil domain containing 80 (ENSG00000091986), score: 0.41 CCL13chemokine (C-C motif) ligand 13 (ENSG00000181374), score: 0.6 CCR3chemokine (C-C motif) receptor 3 (ENSG00000183625), score: 0.49 CD1ECD1e molecule (ENSG00000158488), score: 0.47 CDCA7Lcell division cycle associated 7-like (ENSG00000164649), score: 0.39 CDH2cadherin 2, type 1, N-cadherin (neuronal) (ENSG00000170558), score: 0.39 CFL2cofilin 2 (muscle) (ENSG00000165410), score: 0.44 CHMP7CHMP family, member 7 (ENSG00000147457), score: 0.43 CHRNA1cholinergic receptor, nicotinic, alpha 1 (muscle) (ENSG00000138435), score: 0.65 CHRNA10cholinergic receptor, nicotinic, alpha 10 (ENSG00000129749), score: 0.45 CIDEAcell death-inducing DFFA-like effector a (ENSG00000176194), score: 0.49 CKMcreatine kinase, muscle (ENSG00000104879), score: 0.47 CKMT2creatine kinase, mitochondrial 2 (sarcomeric) (ENSG00000131730), score: 0.47 CLIC5chloride intracellular channel 5 (ENSG00000112782), score: 0.4 CMYA5cardiomyopathy associated 5 (ENSG00000164309), score: 0.43 COL14A1collagen, type XIV, alpha 1 (ENSG00000187955), score: 0.49 COL15A1collagen, type XV, alpha 1 (ENSG00000204291), score: 0.45 COL1A1collagen, type I, alpha 1 (ENSG00000108821), score: 0.4 COL4A6collagen, type IV, alpha 6 (ENSG00000197565), score: 0.45 COQ9coenzyme Q9 homolog (S. cerevisiae) (ENSG00000088682), score: 0.46 COX6A2cytochrome c oxidase subunit VIa polypeptide 2 (ENSG00000156885), score: 0.44 CPA3carboxypeptidase A3 (mast cell) (ENSG00000163751), score: 0.53 CRISPLD1cysteine-rich secretory protein LCCL domain containing 1 (ENSG00000121005), score: 0.42 CRYGNcrystallin, gamma N (ENSG00000127377), score: 0.45 CScitrate synthase (ENSG00000062485), score: 0.43 CSPG4chondroitin sulfate proteoglycan 4 (ENSG00000173546), score: 0.42 CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein) (ENSG00000129170), score: 0.47 CXCR7chemokine (C-X-C motif) receptor 7 (ENSG00000144476), score: 0.4 CYC1cytochrome c-1 (ENSG00000179091), score: 0.4 CYSLTR1cysteinyl leukotriene receptor 1 (ENSG00000173198), score: 0.45 DAPK2death-associated protein kinase 2 (ENSG00000035664), score: 0.41 DDAH1dimethylarginine dimethylaminohydrolase 1 (ENSG00000153904), score: -0.44 DHRS7Cdehydrogenase/reductase (SDR family) member 7C (ENSG00000184544), score: 0.58 DICER1dicer 1, ribonuclease type III (ENSG00000100697), score: -0.42 DISP1dispatched homolog 1 (Drosophila) (ENSG00000154309), score: 0.44 DLK1delta-like 1 homolog (Drosophila) (ENSG00000185559), score: 0.39 DMPKdystrophia myotonica-protein kinase (ENSG00000104936), score: 0.41 DUSP27dual specificity phosphatase 27 (putative) (ENSG00000198842), score: 0.52 DYRK2dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (ENSG00000127334), score: 0.43 EFEMP2EGF-containing fibulin-like extracellular matrix protein 2 (ENSG00000172638), score: 0.4 EGLN3egl nine homolog 3 (C. elegans) (ENSG00000129521), score: 0.41 EHD2EH-domain containing 2 (ENSG00000024422), score: 0.45 EHD4EH-domain containing 4 (ENSG00000103966), score: 0.4 ELMOD3ELMO/CED-12 domain containing 3 (ENSG00000115459), score: 0.45 EMILIN2elastin microfibril interfacer 2 (ENSG00000132205), score: 0.4 ENO3enolase 3 (beta, muscle) (ENSG00000108515), score: 0.44 ESYT2extended synaptotagmin-like protein 2 (ENSG00000117868), score: 0.41 EYA1eyes absent homolog 1 (Drosophila) (ENSG00000104313), score: 0.47 FABP4fatty acid binding protein 4, adipocyte (ENSG00000170323), score: 0.38 FAM104Bfamily with sequence similarity 104, member B (ENSG00000182518), score: -0.41 FAM120AOSfamily with sequence similarity 120A opposite strand (ENSG00000188938), score: 0.4 FAM129Afamily with sequence similarity 129, member A (ENSG00000135842), score: 0.55 FAM180Bfamily with sequence similarity 180, member B (ENSG00000196666), score: 0.46 FAM199Xfamily with sequence similarity 199, X-linked (ENSG00000123575), score: -0.47 FBLN1fibulin 1 (ENSG00000077942), score: 0.46 FBLN2fibulin 2 (ENSG00000163520), score: 0.44 FBN1fibrillin 1 (ENSG00000166147), score: 0.41 FBXO40F-box protein 40 (ENSG00000163833), score: 0.53 FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptide (ENSG00000179639), score: 0.41 FGF16fibroblast growth factor 16 (ENSG00000196468), score: 0.52 FGF7fibroblast growth factor 7 (ENSG00000140285), score: 0.43 FHL1four and a half LIM domains 1 (ENSG00000022267), score: 0.4 FHL2four and a half LIM domains 2 (ENSG00000115641), score: 0.42 FHOD3formin homology 2 domain containing 3 (ENSG00000134775), score: 0.41 FILIP1filamin A interacting protein 1 (ENSG00000118407), score: 0.42 FITM2fat storage-inducing transmembrane protein 2 (ENSG00000197296), score: 0.6 FLIIflightless I homolog (Drosophila) (ENSG00000177731), score: 0.53 FLNAfilamin A, alpha (ENSG00000196924), score: 0.46 FLNCfilamin C, gamma (ENSG00000128591), score: 0.47 FMODfibromodulin (ENSG00000122176), score: 0.49 FNDC1fibronectin type III domain containing 1 (ENSG00000164694), score: 0.58 FRZBfrizzled-related protein (ENSG00000162998), score: 0.48 FSD2fibronectin type III and SPRY domain containing 2 (ENSG00000186628), score: 0.49 FYCO1FYVE and coiled-coil domain containing 1 (ENSG00000163820), score: 0.46 GALNT5UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) (ENSG00000136542), score: 0.5 GAS6growth arrest-specific 6 (ENSG00000183087), score: 0.4 GATA6GATA binding protein 6 (ENSG00000141448), score: 0.45 GDF5growth differentiation factor 5 (ENSG00000125965), score: 0.41 GDF6growth differentiation factor 6 (ENSG00000156466), score: 0.53 GJA3gap junction protein, alpha 3, 46kDa (ENSG00000121743), score: 0.53 GMPRguanosine monophosphate reductase (ENSG00000137198), score: 0.41 GPD1Lglycerol-3-phosphate dehydrogenase 1-like (ENSG00000152642), score: 0.47 GPR1G protein-coupled receptor 1 (ENSG00000183671), score: 0.64 GPR20G protein-coupled receptor 20 (ENSG00000204882), score: 0.53 GRSF1G-rich RNA sequence binding factor 1 (ENSG00000132463), score: 0.38 GSCgoosecoid homeobox (ENSG00000133937), score: 0.54 GSNgelsolin (ENSG00000148180), score: 0.44 HAND1heart and neural crest derivatives expressed 1 (ENSG00000113196), score: 0.45 HAND2heart and neural crest derivatives expressed 2 (ENSG00000164107), score: 0.43 HRChistidine rich calcium binding protein (ENSG00000130528), score: 0.47 HSPB3heat shock 27kDa protein 3 (ENSG00000169271), score: 0.39 HSPB6heat shock protein, alpha-crystallin-related, B6 (ENSG00000004776), score: 0.39 HSPB7heat shock 27kDa protein family, member 7 (cardiovascular) (ENSG00000173641), score: 0.46 HSPG2heparan sulfate proteoglycan 2 (ENSG00000142798), score: 0.4 HTRA3HtrA serine peptidase 3 (ENSG00000170801), score: 0.45 ICAM4intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) (ENSG00000105371), score: 0.4 IDH3Bisocitrate dehydrogenase 3 (NAD+) beta (ENSG00000101365), score: 0.39 IFIT1Binterferon-induced protein with tetratricopeptide repeats 1B (ENSG00000204010), score: 0.41 IGFBP6insulin-like growth factor binding protein 6 (ENSG00000167779), score: 0.49 IGSF10immunoglobulin superfamily, member 10 (ENSG00000152580), score: 0.45 IL11RAinterleukin 11 receptor, alpha (ENSG00000137070), score: 0.43 IL20RAinterleukin 20 receptor, alpha (ENSG00000016402), score: 0.44 ILKintegrin-linked kinase (ENSG00000166333), score: 0.46 ITGB1BP2integrin beta 1 binding protein (melusin) 2 (ENSG00000147166), score: 0.53 ITGB1BP3integrin beta 1 binding protein 3 (ENSG00000077009), score: 0.49 ITLN1intelectin 1 (galactofuranose binding) (ENSG00000179914), score: 0.65 KANK2KN motif and ankyrin repeat domains 2 (ENSG00000197256), score: 0.42 KBTBD10kelch repeat and BTB (POZ) domain containing 10 (ENSG00000239474), score: 0.46 KBTBD5kelch repeat and BTB (POZ) domain containing 5 (ENSG00000157119), score: 0.46 KCNA5potassium voltage-gated channel, shaker-related subfamily, member 5 (ENSG00000130037), score: 0.6 KCNJ2potassium inwardly-rectifying channel, subfamily J, member 2 (ENSG00000123700), score: 0.42 KCNJ5potassium inwardly-rectifying channel, subfamily J, member 5 (ENSG00000120457), score: 0.64 KCNK16potassium channel, subfamily K, member 16 (ENSG00000095981), score: 0.44 KCNMB1potassium large conductance calcium-activated channel, subfamily M, beta member 1 (ENSG00000145936), score: 0.48 KERAkeratocan (ENSG00000139330), score: 0.43 KIAA1543KIAA1543 (ENSG00000076826), score: -0.52 KIAA1598KIAA1598 (ENSG00000187164), score: -0.43 KLHL31kelch-like 31 (Drosophila) (ENSG00000124743), score: 0.53 KLHL38kelch-like 38 (Drosophila) (ENSG00000175946), score: 0.46 LAMA4laminin, alpha 4 (ENSG00000112769), score: 0.47 LAMB2laminin, beta 2 (laminin S) (ENSG00000172037), score: 0.41 LAPTM4Blysosomal protein transmembrane 4 beta (ENSG00000104341), score: 0.46 LARP4BLa ribonucleoprotein domain family, member 4B (ENSG00000107929), score: 0.48 LDB3LIM domain binding 3 (ENSG00000122367), score: 0.46 LEPleptin (ENSG00000174697), score: 1 LGALS12lectin, galactoside-binding, soluble, 12 (ENSG00000133317), score: 0.84 LGR6leucine-rich repeat-containing G protein-coupled receptor 6 (ENSG00000133067), score: 0.52 LIMS2LIM and senescent cell antigen-like domains 2 (ENSG00000072163), score: 0.41 LMOD1leiomodin 1 (smooth muscle) (ENSG00000163431), score: 0.44 LMOD2leiomodin 2 (cardiac) (ENSG00000170807), score: 0.51 LMOD3leiomodin 3 (fetal) (ENSG00000163380), score: 0.49 LOC100127905family with sequence similarity 165, member B pseudogene (ENSG00000198738), score: 0.41 LOC100291405similar to protein tyrosine phosphatase-like A domain containing 1 (ENSG00000074696), score: -0.43 LRRC10leucine rich repeat containing 10 (ENSG00000198812), score: 0.58 LRRC15leucine rich repeat containing 15 (ENSG00000172061), score: 0.43 LRRC2leucine rich repeat containing 2 (ENSG00000163827), score: 0.4 LRRC39leucine rich repeat containing 39 (ENSG00000122477), score: 0.46 LRRN4leucine rich repeat neuronal 4 (ENSG00000125872), score: 0.41 LRRN4CLLRRN4 C-terminal like (ENSG00000177363), score: 0.49 LTBP1latent transforming growth factor beta binding protein 1 (ENSG00000049323), score: 0.48 LTBP2latent transforming growth factor beta binding protein 2 (ENSG00000119681), score: 0.46 LTBP4latent transforming growth factor beta binding protein 4 (ENSG00000090006), score: 0.47 MAMDC2MAM domain containing 2 (ENSG00000165072), score: 0.47 MAP7microtubule-associated protein 7 (ENSG00000135525), score: -0.42 MAPK7mitogen-activated protein kinase 7 (ENSG00000166484), score: 0.51 MAPKAPK2mitogen-activated protein kinase-activated protein kinase 2 (ENSG00000162889), score: 0.39 MAST2microtubule associated serine/threonine kinase 2 (ENSG00000086015), score: 0.38 MBmyoglobin (ENSG00000198125), score: 0.47 MCAMmelanoma cell adhesion molecule (ENSG00000076706), score: 0.4 MED12mediator complex subunit 12 (ENSG00000184634), score: 0.39 MEOX1mesenchyme homeobox 1 (ENSG00000005102), score: 0.45 MFAP2microfibrillar-associated protein 2 (ENSG00000117122), score: 0.41 MMP11matrix metallopeptidase 11 (stromelysin 3) (ENSG00000099953), score: 0.43 MRC2mannose receptor, C type 2 (ENSG00000011028), score: 0.4 MRPL35mitochondrial ribosomal protein L35 (ENSG00000132313), score: 0.44 MS4A8Bmembrane-spanning 4-domains, subfamily A, member 8B (ENSG00000166959), score: 0.54 MSLNmesothelin (ENSG00000102854), score: 0.57 MSRB3methionine sulfoxide reductase B3 (ENSG00000174099), score: 0.54 MXRA5matrix-remodelling associated 5 (ENSG00000101825), score: 0.41 MYBPC3myosin binding protein C, cardiac (ENSG00000134571), score: 0.51 MYH11myosin, heavy chain 11, smooth muscle (ENSG00000133392), score: 0.41 MYH7myosin, heavy chain 7, cardiac muscle, beta (ENSG00000092054), score: 0.47 MYL1myosin, light chain 1, alkali; skeletal, fast (ENSG00000168530), score: 0.76 MYL2myosin, light chain 2, regulatory, cardiac, slow (ENSG00000111245), score: 0.47 MYL3myosin, light chain 3, alkali; ventricular, skeletal, slow (ENSG00000160808), score: 0.41 MYL4myosin, light chain 4, alkali; atrial, embryonic (ENSG00000198336), score: 0.78 MYL9myosin, light chain 9, regulatory (ENSG00000101335), score: 0.39 MYLK3myosin light chain kinase 3 (ENSG00000140795), score: 0.48 MYO18Bmyosin XVIIIB (ENSG00000133454), score: 0.51 MYO6myosin VI (ENSG00000196586), score: -0.42 MYOCmyocilin, trabecular meshwork inducible glucocorticoid response (ENSG00000034971), score: 0.47 MYOCDmyocardin (ENSG00000141052), score: 0.55 MYOM2myomesin (M-protein) 2, 165kDa (ENSG00000036448), score: 0.48 MYOM3myomesin family, member 3 (ENSG00000142661), score: 0.43 MYOZ1myozenin 1 (ENSG00000177791), score: 0.5 MYOZ2myozenin 2 (ENSG00000172399), score: 0.46 MYPNmyopalladin (ENSG00000138347), score: 0.49 NDUFA9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa (ENSG00000139180), score: 0.39 NDUFB10NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa (ENSG00000140990), score: 0.44 NDUFS1NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) (ENSG00000023228), score: 0.43 NDUFS2NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) (ENSG00000158864), score: 0.42 NGFnerve growth factor (beta polypeptide) (ENSG00000134259), score: 0.39 NKIRAS2NFKB inhibitor interacting Ras-like 2 (ENSG00000168256), score: 0.5 NKX2-5NK2 transcription factor related, locus 5 (Drosophila) (ENSG00000183072), score: 0.46 NLRX1NLR family member X1 (ENSG00000160703), score: 0.43 NRAPnebulin-related anchoring protein (ENSG00000197893), score: 0.41 OGDHoxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (ENSG00000105953), score: 0.41 OLFML1olfactomedin-like 1 (ENSG00000183801), score: 0.48 OLFML2Aolfactomedin-like 2A (ENSG00000185585), score: 0.53 OSR2odd-skipped related 2 (Drosophila) (ENSG00000164920), score: 0.39 OTUD1OTU domain containing 1 (ENSG00000165312), score: 0.47 PAMpeptidylglycine alpha-amidating monooxygenase (ENSG00000145730), score: 0.52 PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans) (ENSG00000102981), score: -0.43 PCYT1Aphosphate cytidylyltransferase 1, choline, alpha (ENSG00000161217), score: 0.39 PDLIM3PDZ and LIM domain 3 (ENSG00000154553), score: 0.43 PDLIM5PDZ and LIM domain 5 (ENSG00000163110), score: 0.41 PDPNpodoplanin (ENSG00000162493), score: 0.43 PDZRN3PDZ domain containing ring finger 3 (ENSG00000121440), score: 0.42 PFKMphosphofructokinase, muscle (ENSG00000152556), score: 0.4 PI16peptidase inhibitor 16 (ENSG00000164530), score: 0.44 PITX2paired-like homeodomain 2 (ENSG00000164093), score: 0.58 PKP2plakophilin 2 (ENSG00000057294), score: 0.48 PLA2G2Dphospholipase A2, group IID (ENSG00000117215), score: 0.4 PLECplectin (ENSG00000178209), score: 0.38 PLEKHG7pleckstrin homology domain containing, family G (with RhoGef domain) member 7 (ENSG00000187510), score: 0.54 PLIN1perilipin 1 (ENSG00000166819), score: 0.67 PLIN4perilipin 4 (ENSG00000167676), score: 0.47 PLNphospholamban (ENSG00000198523), score: 0.45 PNPLA2patatin-like phospholipase domain containing 2 (ENSG00000177666), score: 0.51 PODNpodocan (ENSG00000174348), score: 0.38 POPDC2popeye domain containing 2 (ENSG00000121577), score: 0.49 PPP1R12Bprotein phosphatase 1, regulatory (inhibitor) subunit 12B (ENSG00000077157), score: 0.41 PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A (ENSG00000087074), score: 0.39 PPP1R3Aprotein phosphatase 1, regulatory (inhibitor) subunit 3A (ENSG00000154415), score: 0.43 PPP2R3Aprotein phosphatase 2, regulatory subunit B'', alpha (ENSG00000073711), score: 0.42 PRELPproline/arginine-rich end leucine-rich repeat protein (ENSG00000188783), score: 0.4 PRG3proteoglycan 3 (ENSG00000156575), score: 0.56 PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunit (ENSG00000181929), score: 0.45 PRKCZprotein kinase C, zeta (ENSG00000067606), score: -0.43 PRSS35protease, serine, 35 (ENSG00000146250), score: 0.44 PTGFRNprostaglandin F2 receptor negative regulator (ENSG00000134247), score: 0.41 PTRFpolymerase I and transcript release factor (ENSG00000177469), score: 0.44 PYGMphosphorylase, glycogen, muscle (ENSG00000068976), score: 0.41 RASSF3Ras association (RalGDS/AF-6) domain family member 3 (ENSG00000153179), score: 0.5 RBM20RNA binding motif protein 20 (ENSG00000203867), score: 0.45 RBM24RNA binding motif protein 24 (ENSG00000112183), score: 0.44 RBM38RNA binding motif protein 38 (ENSG00000132819), score: 0.43 RBPMS2RNA binding protein with multiple splicing 2 (ENSG00000166831), score: 0.39 RILPL1Rab interacting lysosomal protein-like 1 (ENSG00000188026), score: 0.39 RNF207ring finger protein 207 (ENSG00000158286), score: 0.46 ROR1receptor tyrosine kinase-like orphan receptor 1 (ENSG00000185483), score: 0.46 RPL3Lribosomal protein L3-like (ENSG00000140986), score: 0.45 RRADRas-related associated with diabetes (ENSG00000166592), score: 0.42 RSPO1R-spondin homolog (Xenopus laevis) (ENSG00000169218), score: 0.44 SBK2SH3-binding domain kinase family, member 2 (ENSG00000187550), score: 0.81 SCARA5scavenger receptor class A, member 5 (putative) (ENSG00000168079), score: 0.47 SELPselectin P (granule membrane protein 140kDa, antigen CD62) (ENSG00000174175), score: 0.4 SETDB2SET domain, bifurcated 2 (ENSG00000136169), score: 0.42 SGCAsarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) (ENSG00000108823), score: 0.4 SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein) (ENSG00000170624), score: 0.44 SGCGsarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) (ENSG00000102683), score: 0.47 SIX2SIX homeobox 2 (ENSG00000170577), score: 0.55 SLBPstem-loop binding protein (ENSG00000163950), score: -0.45 SLC12A4solute carrier family 12 (potassium/chloride transporters), member 4 (ENSG00000124067), score: 0.4 SLC25A4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 (ENSG00000151729), score: 0.46 SLC27A6solute carrier family 27 (fatty acid transporter), member 6 (ENSG00000113396), score: 0.49 SLC2A4solute carrier family 2 (facilitated glucose transporter), member 4 (ENSG00000181856), score: 0.5 SLC41A1solute carrier family 41, member 1 (ENSG00000133065), score: 0.41 SLC5A7solute carrier family 5 (choline transporter), member 7 (ENSG00000115665), score: 0.7 SLITRK6SLIT and NTRK-like family, member 6 (ENSG00000184564), score: 0.46 SLNsarcolipin (ENSG00000170290), score: 0.5 SMCR7Smith-Magenis syndrome chromosome region, candidate 7 (ENSG00000177427), score: 0.45 SMPXsmall muscle protein, X-linked (ENSG00000091482), score: 0.51 SMTNsmoothelin (ENSG00000183963), score: 0.42 SMYD1SET and MYND domain containing 1 (ENSG00000115593), score: 0.49 SORBS2sorbin and SH3 domain containing 2 (ENSG00000154556), score: 0.42 SPATS2spermatogenesis associated, serine-rich 2 (ENSG00000123352), score: -0.5 SRFserum response factor (c-fos serum response element-binding transcription factor) (ENSG00000112658), score: 0.49 SRLsarcalumenin (ENSG00000185739), score: 0.48 SYNPO2Lsynaptopodin 2-like (ENSG00000166317), score: 0.46 TANC1tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 (ENSG00000115183), score: 0.47 TAX1BP3Tax1 (human T-cell leukemia virus type I) binding protein 3 (ENSG00000213977), score: 0.41 TBX18T-box 18 (ENSG00000112837), score: 0.45 TBX20T-box 20 (ENSG00000164532), score: 0.52 TBX5T-box 5 (ENSG00000089225), score: 0.62 TCAPtitin-cap (telethonin) (ENSG00000173991), score: 0.41 TECRLtrans-2,3-enoyl-CoA reductase-like (ENSG00000205678), score: 0.55 TLL2tolloid-like 2 (ENSG00000095587), score: 0.52 TLN1talin 1 (ENSG00000137076), score: 0.41 TMEM143transmembrane protein 143 (ENSG00000161558), score: 0.38 TMEM182transmembrane protein 182 (ENSG00000170417), score: 0.43 TMEM43transmembrane protein 43 (ENSG00000170876), score: 0.42 TMEM71transmembrane protein 71 (ENSG00000165071), score: 0.68 TNNC1troponin C type 1 (slow) (ENSG00000114854), score: 0.42 TNNI3troponin I type 3 (cardiac) (ENSG00000129991), score: 0.49 TNNI3KTNNI3 interacting kinase (ENSG00000116783), score: 0.47 TNNT1troponin T type 1 (skeletal, slow) (ENSG00000105048), score: 0.56 TNNT2troponin T type 2 (cardiac) (ENSG00000118194), score: 0.51 TNS1tensin 1 (ENSG00000079308), score: 0.42 TPM1tropomyosin 1 (alpha) (ENSG00000140416), score: 0.4 TRDNtriadin (ENSG00000186439), score: 0.41 TRIM54tripartite motif-containing 54 (ENSG00000138100), score: 0.43 TRIM55tripartite motif-containing 55 (ENSG00000147573), score: 0.42 TRIM63tripartite motif-containing 63 (ENSG00000158022), score: 0.45 TRIM72tripartite motif-containing 72 (ENSG00000177238), score: 0.54 TUBB6tubulin, beta 6 (ENSG00000176014), score: 0.44 TXLNBtaxilin beta (ENSG00000164440), score: 0.46 UNC45Bunc-45 homolog B (C. elegans) (ENSG00000141161), score: 0.5 UPK1Buroplakin 1B (ENSG00000114638), score: 0.45 UQCCubiquinol-cytochrome c reductase complex chaperone (ENSG00000101019), score: 0.5 USP28ubiquitin specific peptidase 28 (ENSG00000048028), score: 0.43 VCLvinculin (ENSG00000035403), score: 0.4 VHLvon Hippel-Lindau tumor suppressor (ENSG00000134086), score: -0.44 VIPR2vasoactive intestinal peptide receptor 2 (ENSG00000106018), score: 0.52 VLDLRvery low density lipoprotein receptor (ENSG00000147852), score: 0.43 WISP2WNT1 inducible signaling pathway protein 2 (ENSG00000064205), score: 0.39 WNT10Awingless-type MMTV integration site family, member 10A (ENSG00000135925), score: 0.48 XGXg blood group (ENSG00000124343), score: 0.5 XIRP1xin actin-binding repeat containing 1 (ENSG00000168334), score: 0.49 ZAKsterile alpha motif and leucine zipper containing kinase AZK (ENSG00000091436), score: 0.41 ZP4zona pellucida glycoprotein 4 (ENSG00000116996), score: 0.61
| Id | species | tissue | sex | individual |
|---|---|---|---|---|
| hsa_ht_m1_ca1 | hsa | ht | m | 1 |
| mml_ht_m_ca1 | mml | ht | m | _ |
| mml_ht_f_ca1 | mml | ht | f | _ |
