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immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

antigen processing and presentation of peptide antigen via MHC class I

The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.

antigen processing and presentation of endogenous peptide antigen

The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell.

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

The process by which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

antigen processing and presentation

The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

antigen processing and presentation of endogenous antigen

The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex.

antigen processing and presentation of endogenous peptide antigen via MHC class I

The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.

antigen processing and presentation of peptide antigen

The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.

all

NA

antigen processing and presentation of endogenous peptide antigen

The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell.

antigen processing and presentation of endogenous peptide antigen via MHC class I

The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

MHC class II protein complex

A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

endomembrane system

A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

integral to endoplasmic reticulum membrane

Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

organelle membrane

The lipid bilayer surrounding an organelle.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to endoplasmic reticulum membrane

Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to organelle membrane

Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

integral to organelle membrane

Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

MHC class I peptide loading complex

A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.

TAP complex

A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intrinsic to organelle membrane

Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

TAP complex

A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum.

intrinsic to endoplasmic reticulum membrane

Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

intrinsic to endoplasmic reticulum membrane

Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

MHC class I peptide loading complex

A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.

TAP complex

A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

intrinsic to organelle membrane

Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

integral to endoplasmic reticulum membrane

Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

integral to organelle membrane

Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

MHC class I peptide loading complex

A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

structural constituent of ribosome

The action of a molecule that contributes to the structural integrity of the ribosome.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transmembrane receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

MHC class II receptor activity

Combining with an MHC class II protein complex to initiate a change in cellular activity.

structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

TAP binding

Interacting selectively and non-covalently with TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2.

TAP1 binding

Interacting selectively and non-covalently with the TAP1 subunit of TAP (transporter associated with antigen processing) protein.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

NA

Id	Pvalue	ExpCount	Count	Size	Term
GO:0019882	1.043e-07	0.8726	11 CD209, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, PSMB9, TAP1, TAP2, TAPBP	37	antigen processing and presentation
GO:0002504	8.286e-06	0.2594	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	11	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002483	9.556e-03	0.1415	3 TAP1, TAP2, TAPBP	6	antigen processing and presentation of endogenous peptide antigen
GO:0019885	9.556e-03	0.1415	3 TAP1, TAP2, TAPBP	6	antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0043558	1.461e-02	0.1651	3 EIF2AK3, EIF2B5, EIF2S1	7	regulation of translational initiation in response to stress
GO:0046967	1.809e-02	0.04717	2 TAP1, TAP2	2	cytosol to ER transport
GO:0046968	1.809e-02	0.04717	2 CD209, TAP2	2	peptide antigen transport
GO:0048002	1.836e-02	0.4009	4 CD209, TAP1, TAP2, TAPBP	17	antigen processing and presentation of peptide antigen
GO:0019883	2.077e-02	0.1887	3 TAP1, TAP2, TAPBP	8	antigen processing and presentation of endogenous antigen
GO:0043555	2.077e-02	0.1887	3 EIF2AK3, EIF2B5, EIF2S1	8	regulation of translation in response to stress
GO:0002474	4.333e-02	0.2594	3 TAP1, TAP2, TAPBP	11	antigen processing and presentation of peptide antigen via MHC class I

Id	Pvalue	ExpCount	Count	Size	Term
GO:0042613	1.915e-07	0.1847	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	8	MHC class II protein complex
GO:0042611	1.272e-05	0.3232	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	14	MHC protein complex
GO:0042825	2.950e-04	0.06926	3 TAP1, TAP2, TAPBP	3	TAP complex
GO:0042824	9.902e-04	0.09235	3 TAP1, TAP2, TAPBP	4	MHC class I peptide loading complex
GO:0000313	1.506e-02	0.808	5 MRPL36, MRPL9, MRPS16, MRPS17, MRPS33	35	organellar ribosome
GO:0005761	1.506e-02	0.808	5 MRPL36, MRPL9, MRPS16, MRPS17, MRPS33	35	mitochondrial ribosome
GO:0000323	1.623e-02	4.294	12 AZU1, CTBS, CTSK, DOC2A, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, MFSD8, TIAL1	186	lytic vacuole
GO:0005764	1.623e-02	4.294	12 AZU1, CTBS, CTSK, DOC2A, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, MFSD8, TIAL1	186	lysosome
GO:0005765	2.050e-02	1.732	7 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, MFSD8	75	lysosomal membrane
GO:0033279	2.065e-02	0.8773	5 MRPL36, MRPS16, MRPS17, MRPS33, RPL37	38	ribosomal subunit
GO:0000314	2.646e-02	0.277	3 MRPS16, MRPS17, MRPS33	12	organellar small ribosomal subunit
GO:0005763	2.646e-02	0.277	3 MRPS16, MRPS17, MRPS33	12	mitochondrial small ribosomal subunit
GO:0043231	3.053e-02	141.4	164 ABCA7, ACSBG1, ADCK2, ALAS2, ALX3, API5, ARL1, ATP5O, ATRIP, ATXN1, AZU1, B3GALT4, B3GAT2, BIRC2, BIRC3, BRD2, C10orf2, C18orf22, C2CD4B, C5orf13, CAMP, CCHCR1, CDC25A, CEBPE, CENPN, CENPO, CHMP5, CKAP4, CTBS, CTSK, CYP2U1, DAXX, DBF4B, DCAF17, DDX41, DIDO1, DNAJC30, DOC2A, DONSON, EIF2AK3, EIF2B5, EIF2S1, ERCC5, EXOSC3, FGF2, GCC2, GFM2, GLI4, GTF2E1, HARS2, HIST1H1B, HIST1H3F, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, HNRNPH3, HSD17B8, HSPA5, HTATIP2, HTT, JMJD6, KIAA0892, LONP2, MAGOHB, MAPK12, MED17, MED28, MED6, MEF2B, MESDC2, MFSD8, MINA, MITD1, MLANA, MMAB, MPHOSPH6, MRPL36, MRPL9, MRPS16, MRPS17, MRPS30, MRPS33, MSMB, MYSM1, NAT10, NDUFB9, NEIL2, NFIL3, NRL, OSGEPL1, PAPD7, PDCD4, POLE4, POLR1E, POLR2F, POLR2I, POU2F3, PPBP, PRICKLE4, PROSC, PSMB8, PSMB9, PTCD3, PTGR2, PYCR1, RFC2, RFX8, RING1, RNMT, RXRB, S100A12, SAP18, SAP30BP, SCYL1, SDCBP, SEC22C, SERBP1, SETMAR, SFXN2, SLC39A7, SMNDC1, SNRNP48, SRFBP1, SRSF5, SUPV3L1, TAP1, TAP2, TAPBP, TCF19, TIAL1, TMCO1, TMEM187, TRDMT1, TRIT1, TXNDC12, UBE2B, UBE2I, URB1, UTP14A, UTP23, VPS52, WDR83, WRB, ZBTB22, ZDHHC8, ZFP41, ZNF232, ZNF275, ZNF324B, ZNF394, ZNF434, ZNF582, ZNF584, ZNF589, ZNF629, ZNF652, ZNF707, ZNF792, ZNF83, ZNRD1, ZZEF1	6123	intracellular membrane-bounded organelle
GO:0043227	3.177e-02	141.5	164 ABCA7, ACSBG1, ADCK2, ALAS2, ALX3, API5, ARL1, ATP5O, ATRIP, ATXN1, AZU1, B3GALT4, B3GAT2, BIRC2, BIRC3, BRD2, C10orf2, C18orf22, C2CD4B, C5orf13, CAMP, CCHCR1, CDC25A, CEBPE, CENPN, CENPO, CHMP5, CKAP4, CTBS, CTSK, CYP2U1, DAXX, DBF4B, DCAF17, DDX41, DIDO1, DNAJC30, DOC2A, DONSON, EIF2AK3, EIF2B5, EIF2S1, ERCC5, EXOSC3, FGF2, GCC2, GFM2, GLI4, GTF2E1, HARS2, HIST1H1B, HIST1H3F, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, HNRNPH3, HSD17B8, HSPA5, HTATIP2, HTT, JMJD6, KIAA0892, LONP2, MAGOHB, MAPK12, MED17, MED28, MED6, MEF2B, MESDC2, MFSD8, MINA, MITD1, MLANA, MMAB, MPHOSPH6, MRPL36, MRPL9, MRPS16, MRPS17, MRPS30, MRPS33, MSMB, MYSM1, NAT10, NDUFB9, NEIL2, NFIL3, NRL, OSGEPL1, PAPD7, PDCD4, POLE4, POLR1E, POLR2F, POLR2I, POU2F3, PPBP, PRICKLE4, PROSC, PSMB8, PSMB9, PTCD3, PTGR2, PYCR1, RFC2, RFX8, RING1, RNMT, RXRB, S100A12, SAP18, SAP30BP, SCYL1, SDCBP, SEC22C, SERBP1, SETMAR, SFXN2, SLC39A7, SMNDC1, SNRNP48, SRFBP1, SRSF5, SUPV3L1, TAP1, TAP2, TAPBP, TCF19, TIAL1, TMCO1, TMEM187, TRDMT1, TRIT1, TXNDC12, UBE2B, UBE2I, URB1, UTP14A, UTP23, VPS52, WDR83, WRB, ZBTB22, ZDHHC8, ZFP41, ZNF232, ZNF275, ZNF324B, ZNF394, ZNF434, ZNF582, ZNF584, ZNF589, ZNF629, ZNF652, ZNF707, ZNF792, ZNF83, ZNRD1, ZZEF1	6129	membrane-bounded organelle
GO:0005840	3.304e-02	1.916	7 MRPL36, MRPL9, MRPS16, MRPS17, MRPS30, MRPS33, RPL37	83	ribosome
GO:0010008	3.851e-02	3.648	10 ABCA7, CHMP5, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, MITD1, VPS52	158	endosome membrane
GO:0044440	3.851e-02	3.648	10 ABCA7, CHMP5, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, MITD1, VPS52	158	endosomal part
GO:0030529	3.961e-02	6.857	15 API5, DDX41, EIF2S1, HNRNPH3, MRPL36, MRPL9, MRPS16, MRPS17, MRPS30, MRPS33, RPL37, SMNDC1, SNRNP48, UTP14A, WDR83	297	ribonucleoprotein complex
GO:0001739	4.584e-02	0.3463	3 BIRC2, RING1, UBE2B	15	sex chromatin
GO:0005759	4.759e-02	3.786	10 ALAS2, C10orf2, HARS2, HSD17B8, MRPL36, MRPL9, MRPS16, MRPS17, MRPS33, SUPV3L1	164	mitochondrial matrix
GO:0031980	4.759e-02	3.786	10 ALAS2, C10orf2, HARS2, HSD17B8, MRPL36, MRPL9, MRPS16, MRPS17, MRPS33, SUPV3L1	164	mitochondrial lumen

Id	Pvalue	ExpCount	Count	Size	Term
GO:0046977	5.702e-04	0.06743	3 TAP1, TAP2, TAPBP	3	TAP binding
GO:0046978	5.702e-04	0.06743	3 TAP1, TAP2, TAPBP	3	TAP1 binding
GO:0032395	3.977e-03	0.1124	3 HLA-DOB, HLA-DPA1, HLA-DRA	5	MHC class II receptor activity
GO:0003735	9.145e-03	1.304	7 MRPL36, MRPL9, MRPS16, MRPS17, MRPS30, MRPS33, RPL37	58	structural constituent of ribosome
GO:0004720	1.389e-02	0.04496	2 LOXL3, LOXL4	2	protein-lysine 6-oxidase activity
GO:0015433	1.389e-02	0.04496	2 TAP2, TAPBP	2	peptide antigen-transporting ATPase activity
GO:0046979	1.389e-02	0.04496	2 TAP1, TAPBP	2	TAP2 binding
GO:0042605	2.088e-02	0.2023	3 CD209, TAP1, TAPBP	9	peptide antigen binding
GO:0015197	2.692e-02	0.2248	3 TAP1, TAP2, TAPBP	10	peptide transporter activity
GO:0015440	3.142e-02	0.06743	2 TAP2, TAPBP	3	peptide-transporting ATPase activity

Id	Pvalue	ExpCount	Count	Size	Term
05322	5.000e-13	1.261	17 CD80, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	52	Systemic lupus erythematosus
04612	3.886e-06	1.067	10 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, HSPA5, TAP1, TAP2, TAPBP	44	Antigen processing and presentation
05330	5.247e-05	0.5819	7 CD80, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	24	Allograft rejection
05332	5.247e-05	0.5819	7 CD80, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	24	Graft-versus-host disease
04940	1.150e-04	0.6546	7 CD80, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	27	Type I diabetes mellitus
05320	1.446e-04	0.6788	7 CD80, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	28	Autoimmune thyroid disease
05310	3.078e-04	0.5091	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	21	Asthma
04672	8.288e-04	0.897	7 CD80, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	37	Intestinal immune network for IgA production
05416	9.691e-04	0.9213	7 CD80, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	38	Viral myocarditis
05140	5.228e-03	1.236	7 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, MAPK12	51	Leishmaniasis
04145	8.608e-03	2.255	9 CD209, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, TAP1, TAP2	93	Phagosome
03020	1.956e-02	0.4606	4 POLR1E, POLR2F, POLR2I, ZNRD1	19	RNA polymerase

No enriched terms

Id	Pvalue	ExpCount	Count	Size
6	3.041e-09	16.64	50 AGER, ATXN1, B3GALT4, B3GAT2, BRD2, C6orf126, CCHCR1, DAXX, ECHDC1, HIST1H1B, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, HSD17B8, PFDN6, PM20D2, PRICKLE4, PRL, PSMB8, PSMB9, RGL2, RING1, RXRB, SFT2D1, SLC39A7, SNRNP48, TAP1, TAP2, TAPBP, TCF19, TCTE3, TRIM26, VNN2, VPS52, WDR46, ZBTB22, ZNRD1	721

Entrez genes

ABCA7ATP-binding cassette, sub-family A (ABC1), member 7 (ENSG00000064687), score: 0.48 ABHD12Babhydrolase domain containing 12B (ENSG00000131969), score: 0.63 ACCN4amiloride-sensitive cation channel 4, pituitary (ENSG00000072182), score: 0.61 ACSBG1acyl-CoA synthetase bubblegum family member 1 (ENSG00000103740), score: -0.65 ADCK2aarF domain containing kinase 2 (ENSG00000133597), score: 0.95 AGERadvanced glycosylation end product-specific receptor (ENSG00000204305), score: 0.59 ALAS2aminolevulinate, delta-, synthase 2 (ENSG00000158578), score: 0.64 ALX3ALX homeobox 3 (ENSG00000156150), score: -0.5 ANKRD53ankyrin repeat domain 53 (ENSG00000144031), score: 0.49 API5apoptosis inhibitor 5 (ENSG00000166181), score: -0.95 ARL1ADP-ribosylation factor-like 1 (ENSG00000120805), score: 0.55 ARR3arrestin 3, retinal (X-arrestin) (ENSG00000120500), score: 0.51 ARV1ARV1 homolog (S. cerevisiae) (ENSG00000173409), score: -0.56 ASB14ankyrin repeat and SOCS box-containing 14 (ENSG00000239388), score: 0.54 ATRIPATR interacting protein (ENSG00000164053), score: 0.86 ATXN1ataxin 1 (ENSG00000124788), score: -0.62 AVILadvillin (ENSG00000135407), score: 0.79 AZU1azurocidin 1 (ENSG00000172232), score: 0.59 B3GALT4UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 (ENSG00000235863), score: -0.69 B3GAT2beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) (ENSG00000112309), score: 0.48 BEST1bestrophin 1 (ENSG00000167995), score: -0.69 BIRC2baculoviral IAP repeat-containing 2 (ENSG00000110330), score: 0.47 BIRC3baculoviral IAP repeat-containing 3 (ENSG00000023445), score: 0.48 BPIL1bactericidal/permeability-increasing protein-like 1 (ENSG00000078898), score: 0.52 BRD2bromodomain containing 2 (ENSG00000204256), score: -1 C10orf2chromosome 10 open reading frame 2 (ENSG00000107815), score: -0.57 C12orf52chromosome 12 open reading frame 52 (ENSG00000139405), score: -0.52 C16orf57chromosome 16 open reading frame 57 (ENSG00000103005), score: -0.56 C16orf61chromosome 16 open reading frame 61 (ENSG00000103121), score: 0.73 C16orf7chromosome 16 open reading frame 7 (ENSG00000075399), score: -0.58 C16orf79chromosome 16 open reading frame 79 (ENSG00000182685), score: -0.64 C17orf67chromosome 17 open reading frame 67 (ENSG00000214226), score: 0.52 C17orf76chromosome 17 open reading frame 76 (ENSG00000181350), score: -0.5 C18orf22chromosome 18 open reading frame 22 (ENSG00000101546), score: -0.58 C1orf192chromosome 1 open reading frame 192 (ENSG00000188931), score: -0.58 C1orf27chromosome 1 open reading frame 27 (ENSG00000157181), score: 0.55 C1orf56chromosome 1 open reading frame 56 (ENSG00000143443), score: -0.61 C1QTNF5C1q and tumor necrosis factor related protein 5 (ENSG00000235718), score: 0.52 C20orf70chromosome 20 open reading frame 70 (ENSG00000131050), score: 0.5 C21orf2chromosome 21 open reading frame 2 (ENSG00000160226), score: -0.55 C2CD4BC2 calcium-dependent domain containing 4B (ENSG00000205502), score: 0.49 C2orf66chromosome 2 open reading frame 66 (ENSG00000187944), score: 0.67 C2orf79chromosome 2 open reading frame 79 (ENSG00000184924), score: -0.52 C3orf37chromosome 3 open reading frame 37 (ENSG00000183624), score: -0.51 C3orf75chromosome 3 open reading frame 75 (ENSG00000163832), score: -0.76 C4orf29chromosome 4 open reading frame 29 (ENSG00000164074), score: 0.51 C5orf13chromosome 5 open reading frame 13 (ENSG00000134986), score: -0.76 C6orf126chromosome 6 open reading frame 126 (ENSG00000196748), score: 0.71 C9orf95chromosome 9 open reading frame 95 (ENSG00000106733), score: 0.51 CA1carbonic anhydrase I (ENSG00000133742), score: 0.69 CAMPcathelicidin antimicrobial peptide (ENSG00000164047), score: 0.5 CASP4caspase 4, apoptosis-related cysteine peptidase (ENSG00000196954), score: 0.47 CCDC152coiled-coil domain containing 152 (ENSG00000198865), score: -0.66 CCDC42Bcoiled-coil domain containing 42B (ENSG00000186710), score: -0.57 CCDC92coiled-coil domain containing 92 (ENSG00000119242), score: -0.52 CCHCR1coiled-coil alpha-helical rod protein 1 (ENSG00000204536), score: -0.71 CD101CD101 molecule (ENSG00000134256), score: 0.61 CD209CD209 molecule (ENSG00000090659), score: 0.47 CD80CD80 molecule (ENSG00000121594), score: 0.52 CDC25Acell division cycle 25 homolog A (S. pombe) (ENSG00000164045), score: 0.47 CEBPECCAAT/enhancer binding protein (C/EBP), epsilon (ENSG00000092067), score: 0.72 CENPNcentromere protein N (ENSG00000166451), score: -0.65 CENPOcentromere protein O (ENSG00000138092), score: -0.63 CFDP1craniofacial development protein 1 (ENSG00000153774), score: 0.51 CHMP5chromatin modifying protein 5 (ENSG00000086065), score: 0.48 CHRNEcholinergic receptor, nicotinic, epsilon (ENSG00000108556), score: -0.5 CKAP4cytoskeleton-associated protein 4 (ENSG00000136026), score: 0.5 CLEC5AC-type lectin domain family 5, member A (ENSG00000090269), score: 0.81 COL7A1collagen, type VII, alpha 1 (ENSG00000114270), score: -0.5 COMMD3COMM domain containing 3 (ENSG00000148444), score: 0.52 CTBSchitobiase, di-N-acetyl- (ENSG00000117151), score: 0.48 CTSKcathepsin K (ENSG00000143387), score: 0.61 CYB561D1cytochrome b-561 domain containing 1 (ENSG00000174151), score: -0.54 CYP2U1cytochrome P450, family 2, subfamily U, polypeptide 1 (ENSG00000155016), score: 0.49 DAXXdeath-domain associated protein (ENSG00000204209), score: -0.96 DBF4BDBF4 homolog B (S. cerevisiae) (ENSG00000161692), score: -0.55 DCAF17DDB1 and CUL4 associated factor 17 (ENSG00000115827), score: -0.62 DDIT4DNA-damage-inducible transcript 4 (ENSG00000168209), score: 0.52 DDX18DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 (ENSG00000088205), score: 0.5 DDX41DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (ENSG00000183258), score: -0.55 DIDO1death inducer-obliterator 1 (ENSG00000101191), score: 0.47 DNAJC30DnaJ (Hsp40) homolog, subfamily C, member 30 (ENSG00000176410), score: -0.5 DNAL1dynein, axonemal, light chain 1 (ENSG00000119661), score: 0.7 DOC2Adouble C2-like domains, alpha (ENSG00000149927), score: -0.57 DONSONdownstream neighbor of SON (ENSG00000159147), score: -0.57 ECHDC1enoyl CoA hydratase domain containing 1 (ENSG00000093144), score: 0.52 EIF2AK3eukaryotic translation initiation factor 2-alpha kinase 3 (ENSG00000172071), score: 0.51 EIF2B5eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa (ENSG00000145191), score: 0.63 EIF2S1eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (ENSG00000134001), score: 0.48 EMR3egf-like module containing, mucin-like, hormone receptor-like 3 (ENSG00000131355), score: 0.78 ERCC5excision repair cross-complementing rodent repair deficiency, complementation group 5 (ENSG00000134899), score: 0.53 EXOSC3exosome component 3 (ENSG00000107371), score: 0.61 FAM134Cfamily with sequence similarity 134, member C (ENSG00000141699), score: -0.51 FAM162Afamily with sequence similarity 162, member A (ENSG00000114023), score: 0.52 FAM166Afamily with sequence similarity 166, member A (ENSG00000188163), score: -0.9 FAM173Bfamily with sequence similarity 173, member B (ENSG00000150756), score: 0.59 FAM174Bfamily with sequence similarity 174, member B (ENSG00000185442), score: -0.54 FAM18B2family with sequence similarity 18, member B2 (ENSG00000239704), score: -0.52 FAM36Afamily with sequence similarity 36, member A (ENSG00000203667), score: 0.57 FBXO21F-box protein 21 (ENSG00000135108), score: -0.5 FGF2fibroblast growth factor 2 (basic) (ENSG00000138685), score: -0.75 FRMD8FERM domain containing 8 (ENSG00000126391), score: -0.77 GCC2GRIP and coiled-coil domain containing 2 (ENSG00000135968), score: 0.49 GFM2G elongation factor, mitochondrial 2 (ENSG00000164347), score: 0.61 GHRHgrowth hormone releasing hormone (ENSG00000118702), score: 0.88 GLI4GLI family zinc finger 4 (ENSG00000181638), score: -0.52 GLIPR1GLI pathogenesis-related 1 (ENSG00000139278), score: 0.54 GLTPglycolipid transfer protein (ENSG00000139433), score: -0.67 GNGT1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 (ENSG00000127928), score: 0.59 GPR107G protein-coupled receptor 107 (ENSG00000148358), score: -0.64 GPR44G protein-coupled receptor 44 (ENSG00000183134), score: -0.52 GPR97G protein-coupled receptor 97 (ENSG00000182885), score: 0.48 GTF2E1general transcription factor IIE, polypeptide 1, alpha 56kDa (ENSG00000153767), score: 0.52 GZMKgranzyme K (granzyme 3; tryptase II) (ENSG00000113088), score: 0.51 HARS2histidyl-tRNA synthetase 2, mitochondrial (putative) (ENSG00000112855), score: 0.62 HIST1H1Bhistone cluster 1, H1b (ENSG00000184357), score: 0.54 HIST1H3Ahistone cluster 1, H3a (ENSG00000112727), score: 0.53 HLA-DMAmajor histocompatibility complex, class II, DM alpha (ENSG00000204257), score: -0.68 HLA-DMBmajor histocompatibility complex, class II, DM beta (ENSG00000242574), score: -0.62 HLA-DOBmajor histocompatibility complex, class II, DO beta (ENSG00000204267), score: -0.82 HLA-DPA1major histocompatibility complex, class II, DP alpha 1 (ENSG00000231389), score: -0.75 HLA-DPB1major histocompatibility complex, class II, DP beta 1 (ENSG00000223865), score: -0.77 HLA-DRAmajor histocompatibility complex, class II, DR alpha (ENSG00000204287), score: -0.78 HNRNPH3heterogeneous nuclear ribonucleoprotein H3 (2H9) (ENSG00000096746), score: 0.53 HSD17B8hydroxysteroid (17-beta) dehydrogenase 8 (ENSG00000204228), score: -0.75 HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (ENSG00000044574), score: 0.48 HTATIP2HIV-1 Tat interactive protein 2, 30kDa (ENSG00000109854), score: -0.62 HTThuntingtin (ENSG00000197386), score: -0.49 IBSPintegrin-binding sialoprotein (ENSG00000029559), score: 0.57 IL34interleukin 34 (ENSG00000157368), score: 0.49 JMJD6jumonji domain containing 6 (ENSG00000070495), score: 0.5 KIAA0195KIAA0195 (ENSG00000177728), score: -0.56 KIAA0892KIAA0892 (ENSG00000129933), score: -0.55 KRT27keratin 27 (ENSG00000171446), score: 0.56 LIFleukemia inhibitory factor (cholinergic differentiation factor) (ENSG00000128342), score: 0.49 LONP2lon peptidase 2, peroxisomal (ENSG00000102910), score: 0.52 LOXL3lysyl oxidase-like 3 (ENSG00000115318), score: -0.78 LOXL4lysyl oxidase-like 4 (ENSG00000138131), score: 0.5 LRRC23leucine rich repeat containing 23 (ENSG00000010626), score: -0.57 LYG2lysozyme G-like 2 (ENSG00000185674), score: 0.82 MAGOHBmago-nashi homolog B (Drosophila) (ENSG00000111196), score: 0.52 MAPK12mitogen-activated protein kinase 12 (ENSG00000188130), score: -0.6 MED17mediator complex subunit 17 (ENSG00000042429), score: 0.58 MED28mediator complex subunit 28 (ENSG00000118579), score: 0.53 MED6mediator complex subunit 6 (ENSG00000133997), score: -0.6 MEF2Bmyocyte enhancer factor 2B (ENSG00000064489), score: -0.7 MESDC2mesoderm development candidate 2 (ENSG00000117899), score: 0.61 MFSD8major facilitator superfamily domain containing 8 (ENSG00000164073), score: 0.47 MINAMYC induced nuclear antigen (ENSG00000170854), score: 0.58 MITD1MIT, microtubule interacting and transport, domain containing 1 (ENSG00000158411), score: 0.55 MLANAmelan-A (ENSG00000120215), score: 0.7 MMABmethylmalonic aciduria (cobalamin deficiency) cblB type (ENSG00000139428), score: 0.54 MMP8matrix metallopeptidase 8 (neutrophil collagenase) (ENSG00000118113), score: 0.51 MPHOSPH6M-phase phosphoprotein 6 (ENSG00000135698), score: 0.49 MRPL36mitochondrial ribosomal protein L36 (ENSG00000171421), score: -0.7 MRPL9mitochondrial ribosomal protein L9 (ENSG00000143436), score: 0.54 MRPS16mitochondrial ribosomal protein S16 (ENSG00000182180), score: 0.48 MRPS17mitochondrial ribosomal protein S17 (ENSG00000239789), score: 0.48 MRPS30mitochondrial ribosomal protein S30 (ENSG00000112996), score: -0.58 MRPS33mitochondrial ribosomal protein S33 (ENSG00000090263), score: 0.5 MSMBmicroseminoprotein, beta- (ENSG00000138294), score: 0.55 MTERFD2MTERF domain containing 2 (ENSG00000122085), score: 0.48 MTHFD2Lmethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like (ENSG00000163738), score: 0.51 MYOZ3myozenin 3 (ENSG00000164591), score: 0.62 MYSM1Myb-like, SWIRM and MPN domains 1 (ENSG00000162601), score: 0.54 N4BP2L2NEDD4 binding protein 2-like 2 (ENSG00000139617), score: -0.52 NAGKN-acetylglucosamine kinase (ENSG00000124357), score: 0.57 NAT10N-acetyltransferase 10 (GCN5-related) (ENSG00000135372), score: -0.55 NBEAL1neurobeachin-like 1 (ENSG00000144426), score: 0.48 NDUFB9NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa (ENSG00000147684), score: -0.62 NEIL2nei endonuclease VIII-like 2 (E. coli) (ENSG00000154328), score: 0.51 NFIL3nuclear factor, interleukin 3 regulated (ENSG00000165030), score: 0.47 NLRP12NLR family, pyrin domain containing 12 (ENSG00000142405), score: 0.49 NRLneural retina leucine zipper (ENSG00000129535), score: -0.53 NT5C3L5'-nucleotidase, cytosolic III-like (ENSG00000141698), score: -0.53 OR1D2olfactory receptor, family 1, subfamily D, member 2 (ENSG00000184166), score: 0.52 OSGEPL1O-sialoglycoprotein endopeptidase-like 1 (ENSG00000128694), score: 0.49 PAPD7PAP associated domain containing 7 (ENSG00000112941), score: -0.54 PDCD4programmed cell death 4 (neoplastic transformation inhibitor) (ENSG00000150593), score: 0.48 PFDN6prefoldin subunit 6 (ENSG00000204220), score: -0.99 PGLYRP1peptidoglycan recognition protein 1 (ENSG00000008438), score: 0.49 PHF23PHD finger protein 23 (ENSG00000040633), score: 0.97 PIM2pim-2 oncogene (ENSG00000102096), score: 0.53 PLA2G16phospholipase A2, group XVI (ENSG00000176485), score: 0.56 PLA2G2Fphospholipase A2, group IIF (ENSG00000158786), score: 0.52 PLEKHG2pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (ENSG00000090924), score: 0.53 PLTPphospholipid transfer protein (ENSG00000100979), score: -0.54 PM20D2peptidase M20 domain containing 2 (ENSG00000146281), score: 0.52 PODNpodocan (ENSG00000174348), score: 0.52 POLE4polymerase (DNA-directed), epsilon 4 (p12 subunit) (ENSG00000115350), score: 0.49 POLR1Epolymerase (RNA) I polypeptide E, 53kDa (ENSG00000137054), score: 0.5 POLR2Fpolymerase (RNA) II (DNA directed) polypeptide F (ENSG00000100142), score: -0.7 POLR2Ipolymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa (ENSG00000105258), score: -0.64 POU2F3POU class 2 homeobox 3 (ENSG00000137709), score: 0.55 PPA1pyrophosphatase (inorganic) 1 (ENSG00000180817), score: -0.52 PPBPpro-platelet basic protein (chemokine (C-X-C motif) ligand 7) (ENSG00000163736), score: 0.59 PPP2R2Dprotein phosphatase 2, regulatory subunit B, delta (ENSG00000175470), score: -0.5 PRICKLE4prickle homolog 4 (Drosophila) (ENSG00000124593), score: -0.54 PRLprolactin (ENSG00000172179), score: 0.72 PRMT3protein arginine methyltransferase 3 (ENSG00000185238), score: 0.52 PROSCproline synthetase co-transcribed homolog (bacterial) (ENSG00000147471), score: 0.48 PRSS53protease, serine, 53 (ENSG00000151006), score: 0.55 PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (ENSG00000204264), score: -0.65 PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) (ENSG00000240065), score: -0.7 PTCD3Pentatricopeptide repeat domain 3 (ENSG00000132300), score: 0.68 PTGR2prostaglandin reductase 2 (ENSG00000140043), score: 0.49 PYCR1pyrroline-5-carboxylate reductase 1 (ENSG00000183010), score: 0.51 R3HDMLR3H domain containing-like (ENSG00000101074), score: 0.51 RAB40ARAB40A, member RAS oncogene family (ENSG00000172476), score: 0.58 RFC2replication factor C (activator 1) 2, 40kDa (ENSG00000049541), score: 0.5 RFX8regulatory factor X, 8 (ENSG00000196460), score: 0.68 RGL2ral guanine nucleotide dissociation stimulator-like 2 (ENSG00000237441), score: -0.97 RING1ring finger protein 1 (ENSG00000204227), score: -1 RNLSrenalase, FAD-dependent amine oxidase (ENSG00000184719), score: 0.51 RNMTRNA (guanine-7-) methyltransferase (ENSG00000101654), score: -0.7 RPL37ribosomal protein L37 (ENSG00000145592), score: -0.85 RPUSD3RNA pseudouridylate synthase domain containing 3 (ENSG00000156990), score: -0.54 RRP15ribosomal RNA processing 15 homolog (S. cerevisiae) (ENSG00000067533), score: 0.57 RXRBretinoid X receptor, beta (ENSG00000204231), score: -0.99 S100A12S100 calcium binding protein A12 (ENSG00000163221), score: 0.51 SAP18Sin3A-associated protein, 18kDa (ENSG00000150459), score: 0.62 SAP30BPSAP30 binding protein (ENSG00000161526), score: 0.57 SCARF1scavenger receptor class F, member 1 (ENSG00000074660), score: 0.49 SCGB3A2secretoglobin, family 3A, member 2 (ENSG00000164265), score: 0.56 SCYL1SCY1-like 1 (S. cerevisiae) (ENSG00000142186), score: 0.96 SDCBPsyndecan binding protein (syntenin) (ENSG00000137575), score: 0.48 SEC22CSEC22 vesicle trafficking protein homolog C (S. cerevisiae) (ENSG00000093183), score: -0.56 SERBP1SERPINE1 mRNA binding protein 1 (ENSG00000142864), score: 0.52 SETMARSET domain and mariner transposase fusion gene (ENSG00000170364), score: 0.47 SFT2D1SFT2 domain containing 1 (ENSG00000198818), score: -0.55 SFXN2sideroflexin 2 (ENSG00000156398), score: 0.48 SLC39A7solute carrier family 39 (zinc transporter), member 7 (ENSG00000112473), score: -0.97 SMNDC1survival motor neuron domain containing 1 (ENSG00000119953), score: 0.57 SNRNP48small nuclear ribonucleoprotein 48kDa (U11/U12) (ENSG00000168566), score: 0.56 SRFBP1serum response factor binding protein 1 (ENSG00000151304), score: 0.62 SRSF5serine/arginine-rich splicing factor 5 (ENSG00000100650), score: 0.48 SUPV3L1suppressor of var1, 3-like 1 (S. cerevisiae) (ENSG00000156502), score: 0.61 TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) (ENSG00000168394), score: -0.77 TAPBPTAP binding protein (tapasin) (ENSG00000231925), score: -0.94 TBC1D14TBC1 domain family, member 14 (ENSG00000132405), score: -0.53 TCF19transcription factor 19 (ENSG00000137310), score: -0.6 TCTE3t-complex-associated-testis-expressed 3 (ENSG00000184786), score: 0.52 TCTEX1D1Tctex1 domain containing 1 (ENSG00000152760), score: 0.59 TFF1trefoil factor 1 (ENSG00000160182), score: 0.61 THTPAthiamine triphosphatase (ENSG00000157306), score: -0.52 THUMPD3THUMP domain containing 3 (ENSG00000134077), score: -0.82 TIAL1TIA1 cytotoxic granule-associated RNA binding protein-like 1 (ENSG00000151923), score: 0.5 TIGITT cell immunoreceptor with Ig and ITIM domains (ENSG00000181847), score: 0.5 TMC3transmembrane channel-like 3 (ENSG00000188869), score: 0.56 TMCO1transmembrane and coiled-coil domains 1 (ENSG00000143183), score: 0.52 TMEM101transmembrane protein 101 (ENSG00000091947), score: -0.54 TMEM131transmembrane protein 131 (ENSG00000075568), score: -0.63 TMEM149transmembrane protein 149 (ENSG00000126246), score: 0.51 TMEM187transmembrane protein 187 (ENSG00000177854), score: -0.52 TMEM80transmembrane protein 80 (ENSG00000177042), score: -0.64 TRAT1T cell receptor associated transmembrane adaptor 1 (ENSG00000163519), score: 0.51 TRDMT1tRNA aspartic acid methyltransferase 1 (ENSG00000107614), score: 0.48 TRIM26tripartite motif-containing 26 (ENSG00000234127), score: -0.95 TRIT1tRNA isopentenyltransferase 1 (ENSG00000043514), score: 0.61 TRUB2TruB pseudouridine (psi) synthase homolog 2 (E. coli) (ENSG00000167112), score: 0.5 TXNDC12thioredoxin domain containing 12 (endoplasmic reticulum) (ENSG00000117862), score: 0.48 UBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog) (ENSG00000119048), score: 0.49 UBE2G1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) (ENSG00000132388), score: 0.52 UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) (ENSG00000103275), score: -0.51 URB1URB1 ribosome biogenesis 1 homolog (S. cerevisiae) (ENSG00000142207), score: -0.51 UTP14AUTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) (ENSG00000156697), score: 0.57 UTP23UTP23, small subunit (SSU) processome component, homolog (yeast) (ENSG00000147679), score: 0.5 VILLvillin-like (ENSG00000136059), score: 0.48 VMO1vitelline membrane outer layer 1 homolog (chicken) (ENSG00000182853), score: 0.53 VNN2vanin 2 (ENSG00000112303), score: 0.62 VPS52vacuolar protein sorting 52 homolog (S. cerevisiae) (ENSG00000223501), score: -1 WBP5WW domain binding protein 5 (ENSG00000185222), score: 0.53 WDR46WD repeat domain 46 (ENSG00000227057), score: -0.98 WDR83WD repeat domain 83 (ENSG00000123154), score: -0.5 WRBtryptophan rich basic protein (ENSG00000182093), score: -0.52 ZBTB22zinc finger and BTB domain containing 22 (ENSG00000236104), score: -0.94 ZCCHC4zinc finger, CCHC domain containing 4 (ENSG00000168228), score: 0.48 ZDHHC8zinc finger, DHHC-type containing 8 (ENSG00000099904), score: -0.5 ZNF232zinc finger protein 232 (ENSG00000167840), score: 0.63 ZNF275zinc finger protein 275 (ENSG00000063587), score: -0.51 ZNF394zinc finger protein 394 (ENSG00000160908), score: 0.6 ZNF434zinc finger protein 434 (ENSG00000140987), score: -0.54 ZNF582zinc finger protein 582 (ENSG00000018869), score: 0.47 ZNF584zinc finger protein 584 (ENSG00000171574), score: -0.53 ZNF589zinc finger protein 589 (ENSG00000164048), score: -0.77 ZNF629zinc finger protein 629 (ENSG00000102870), score: -0.63 ZNF652zinc finger protein 652 (ENSG00000198740), score: 0.53 ZNF707zinc finger protein 707 (ENSG00000181135), score: -0.51 ZNF792zinc finger protein 792 (ENSG00000180884), score: 0.5 ZNF83zinc finger protein 83 (ENSG00000167766), score: 0.48 ZNRD1zinc ribbon domain containing 1 (ENSG00000066379), score: -0.9 ZZEF1zinc finger, ZZ-type with EF-hand domain 1 (ENSG00000074755), score: -0.5

Non-Entrez genes

ENSG00000119242Unknown, score: 0.56 ENSG00000103121Unknown, score: 0.49 ENSG00000164074Unknown, score: 0.49

Id	species	tissue	sex	individual
ppy_br_m_ca1	ppy	br	m	_
ppy_br_f_ca1	ppy	br	f	_
ppy_cb_f_ca1	ppy	cb	f	_
ppy_kd_m_ca1	ppy	kd	m	_
ppy_kd_f_ca1	ppy	kd	f	_
ppy_ht_m_ca1	ppy	ht	m	_
ppy_ht_f_ca1	ppy	ht	f	_
ppy_lv_m_ca1	ppy	lv	m	_
ppy_lv_f_ca1	ppy	lv	f	_