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metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

immune effector process

Any process of the immune system that occurs as part of an immune response.

activation of immune response

Any process that initiates an immune response.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

leukocyte mediated immunity

Any process involved in the carrying out of an immune response by a leukocyte.

lymphocyte mediated immunity

Any process involved in the carrying out of an immune response by a lymphocyte.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

protein maturation by peptide bond cleavage

The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

glycerol ether metabolic process

The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

steroid catabolic process

The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cellular aromatic compound metabolic process

The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

lipid transport

The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

humoral immune response

An immune response mediated through a body fluid.

blood coagulation, extrinsic pathway

A pathway of blood coagulation in which the earlier stages of the cascade are bypassed and the activation of factor X to factor Xa is effected by the combination of factor VIIa + thromboplastin; this second pathway occurs when tissue extracts are present in optimal amounts and is much more rapid than the intrinsic pathway.

hemostasis

The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

bile acid metabolic process

The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

cell death

A biological process that results in permanent cessation of all vital functions of a cell.

cytolysis

The rupture of cell membranes and the loss of cytoplasm.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

response to drug

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

response to endogenous stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.

response to hormone stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to organic substance

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

gene expression

The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

lipid localization

Any process by which a lipid is transported to, or maintained in, a specific location.

sterol transport

The directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

lipid catabolic process

The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

cellular component organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

death

A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.

protein processing

Any protein maturation process achieved by the cleavage of peptide bonds.

drug metabolic process

The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.

organic ether metabolic process

The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

aromatic compound catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

carboxylic acid metabolic process

The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

cholesterol transport

The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells by means of some external agent such as a transporter or pore.

bile acid catabolic process

The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

regulation of lipid transport

Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore.

negative regulation of lipid transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore.

regulation of sterol transport

Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore.

negative regulation of sterol transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore.

regulation of cholesterol transport

Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells by means of some external agent such as a transporter or pore.

negative regulation of cholesterol transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells by means of some external agent such as a transporter or pore.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

monocarboxylic acid metabolic process

The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

macromolecule localization

Any process by which a macromolecule is transported to, or maintained in, a specific location.

macromolecular complex remodeling

The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex.

protein-lipid complex remodeling

The acquisition, loss or modification of a protein or lipid within a protein-lipid complex.

plasma lipoprotein particle remodeling

The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT).

lipoprotein particle clearance

The process by which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.

chylomicron remnant clearance

The process by which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

homeostatic process

Any biological process involved in the maintenance of an internal steady-state.

cholesterol homeostasis

Any process involved in the maintenance of an internal steady-state of cholesterol within an organism or cell.

fibrinolysis

An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots.

drug catabolic process

The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease.

exogenous drug catabolic process

The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism.

negative regulation of catalytic activity

Any process that stops or reduces the activity of an enzyme.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

response to peptide hormone stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

macromolecular complex subunit organization

Any process by which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a macromolecular complex.

negative regulation of molecular function

Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular lipid catabolic process

The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

glycerolipid metabolic process

The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.

glycerolipid catabolic process

The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

chemical homeostasis

Any biological process involved in the maintenance of an internal steady-state of a chemical.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of catalytic activity

Any process that modulates the activity of an enzyme.

coagulation

The process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

regulation of coagulation

Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

positive regulation of coagulation

Any process that activates or increases the frequency, rate or extent of coagulation.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of lipoprotein lipase activity

Any process that modulates the activity of the enzyme lipoprotein lipase.

negative regulation of lipoprotein lipase activity

Any process that stops or reduces the activity of the enzyme lipoprotein lipase.

regulation of transport

Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore.

negative regulation of transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of hydrolase activity

Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

negative regulation of hydrolase activity

Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

regulation of fibrinolysis

Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

lipid homeostasis

Any process involved in the maintenance of an internal steady-state of lipid within an organism or cell.

sterol homeostasis

Any process involved in the maintenance of an internal steady-state of sterol within an organism or cell.

regulation of lipase activity

Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.

negative regulation of lipase activity

Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.

regulation of wound healing

Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

regulation of molecular function

Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.

regulation of response to stress

Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

all

NA

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

cell death

A biological process that results in permanent cessation of all vital functions of a cell.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

immune effector process

Any process of the immune system that occurs as part of an immune response.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of coagulation

Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

positive regulation of coagulation

Any process that activates or increases the frequency, rate or extent of coagulation.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of response to stress

Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

regulation of transport

Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore.

negative regulation of transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

regulation of catalytic activity

Any process that modulates the activity of an enzyme.

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

cellular lipid catabolic process

The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

aromatic compound catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

drug catabolic process

The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

cellular lipid catabolic process

The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

lipid catabolic process

The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

activation of immune response

Any process that initiates an immune response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

positive regulation of coagulation

Any process that activates or increases the frequency, rate or extent of coagulation.

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

negative regulation of transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

response to hormone stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.

lipid transport

The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

regulation of lipid transport

Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore.

negative regulation of lipid transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore.

negative regulation of catalytic activity

Any process that stops or reduces the activity of an enzyme.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

exogenous drug catabolic process

The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism.

negative regulation of hydrolase activity

Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.

glycerolipid catabolic process

The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

steroid catabolic process

The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

negative regulation of lipid transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

regulation of wound healing

Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

regulation of sterol transport

Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore.

negative regulation of sterol transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore.

bile acid catabolic process

The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.

negative regulation of lipase activity

Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

bile acid catabolic process

The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.

regulation of fibrinolysis

Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

negative regulation of sterol transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore.

regulation of cholesterol transport

Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells by means of some external agent such as a transporter or pore.

negative regulation of cholesterol transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells by means of some external agent such as a transporter or pore.

negative regulation of lipoprotein lipase activity

Any process that stops or reduces the activity of the enzyme lipoprotein lipase.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

bile acid metabolic process

The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

negative regulation of cholesterol transport

Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells by means of some external agent such as a transporter or pore.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

cell fraction

A generic term for parts of cells prepared by disruptive biochemical techniques.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

membrane fraction

That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes.

insoluble fraction

That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

microsome

Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g.

endomembrane system

A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

organelle membrane

The lipid bilayer surrounding an organelle.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

protein-lipid complex

A macromolecular complex containing both protein and lipid molecules.

plasma lipoprotein particle

A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.

high-density lipoprotein particle

A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

vesicular fraction

Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized.

chylomicron

A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

all

NA

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

plasma lipoprotein particle

A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma lipoprotein particle

A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

carboxylesterase activity

Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion.

monooxygenase activity

Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.

enzyme inhibitor activity

Stops, prevents or reduces the activity of an enzyme.

endopeptidase inhibitor activity

Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

serine-type endopeptidase inhibitor activity

Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

carbohydrate binding

Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

organic acid transmembrane transporter activity

Catalysis of the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

steroid binding

Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.

oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

lipid binding

Interacting selectively and non-covalently with a lipid.

endopeptidase regulator activity

Modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

amino acid binding

Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

hydrolase activity, acting on ester bonds

Catalysis of the hydrolysis of any ester bond.

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

vitamin binding

Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

enzyme regulator activity

Modulates the activity of an enzyme.

carboxylic acid binding

Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

amine binding

Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.

carboxylic acid transmembrane transporter activity

Catalysis of the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

peptidase regulator activity

Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

amino acid binding

Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

endopeptidase inhibitor activity

Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0008202	7.641e-10	4.463	25 AGTR1, AKR1D1, APOB, APOC1, APOC3, BAAT, CFTR, CYP1A2, CYP39A1, DHRS2, HMGCS2, HSD11B1, INSIG1, LEPR, LIPC, NPC1L1, NR1H4, NR1I2, NR5A2, PPARD, SCP2, SIGMAR1, SRD5A2, SULT1B1, SULT2A1	174	steroid metabolic process
GO:0006082	1.161e-08	12.47	40 ACOT12, ACOX1, ACSL5, AGXT, AKR1D1, AMDHD1, APOC1, APOC3, ARG1, ART4, ASPG, BAAT, CTPS, CYP1A2, CYP2C8, CYP39A1, GCH1, GNE, GNMT, GPAM, HAL, HAO1, HPGD, LIPC, MAT1A, NR1H4, NR5A2, OTC, PON1, PON3, PPARD, SDS, SLC25A15, SLC35D1, SULT2A1, TAT, TDO2, TMEM195, UGP2, UROC1	486	organic acid metabolic process
GO:0019752	3.051e-08	12.36	39 ACOT12, ACOX1, ACSL5, AGXT, AKR1D1, AMDHD1, APOC1, APOC3, ARG1, ART4, ASPG, BAAT, CTPS, CYP1A2, CYP39A1, GCH1, GNE, GNMT, GPAM, HAL, HAO1, HPGD, LIPC, MAT1A, NR1H4, NR5A2, OTC, PON1, PON3, PPARD, SDS, SLC25A15, SLC35D1, SULT2A1, TAT, TDO2, TMEM195, UGP2, UROC1	482	carboxylic acid metabolic process
GO:0043436	3.051e-08	12.36	39 ACOT12, ACOX1, ACSL5, AGXT, AKR1D1, AMDHD1, APOC1, APOC3, ARG1, ART4, ASPG, BAAT, CTPS, CYP1A2, CYP39A1, GCH1, GNE, GNMT, GPAM, HAL, HAO1, HPGD, LIPC, MAT1A, NR1H4, NR5A2, OTC, PON1, PON3, PPARD, SDS, SLC25A15, SLC35D1, SULT2A1, TAT, TDO2, TMEM195, UGP2, UROC1	482	oxoacid metabolic process
GO:0042180	5.310e-08	12.62	39 ACOT12, ACOX1, ACSL5, AGXT, AKR1D1, AMDHD1, APOC1, APOC3, ARG1, ART4, ASPG, BAAT, CTPS, CYP1A2, CYP39A1, GCH1, GNE, GNMT, GPAM, HAL, HAO1, HPGD, LIPC, MAT1A, NR1H4, NR5A2, OTC, PON1, PON3, PPARD, SDS, SLC25A15, SLC35D1, SULT2A1, TAT, TDO2, TMEM195, UGP2, UROC1	492	cellular ketone metabolic process
GO:0006066	9.680e-08	9.618	33 ADH4, ADH6, AKR1D1, APOB, APOC1, APOC3, BCHE, CFTR, CYP39A1, DHTKD1, ENPP1, GCH1, GNE, GNMT, GNPNAT1, GYS2, HAO1, HMGCS2, INSIG1, LEPR, LIPC, MOGAT1, MOGAT3, NPC1L1, NUDT5, PDX1, PON1, PPARD, PYGL, SDS, SIGMAR1, SLC35D1, UGP2	375	alcohol metabolic process
GO:0050896	1.816e-07	64.81	109 ABCG5, ACSL5, ADH6, AGTR1, AGXT, ALB, AMBP, APCS, APOB, AQP9, BCHE, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CCR2, CD247, CD4, CFH, CFTR, CIDEB, CLEC1B, CNPY3, CPB2, CREB3L3, CTPS, CXCL2, CYP1A2, CYP2C8, DHRS2, EI24, ENPP1, EPHX1, ERRFI1, F10, F11, F2, F7, F9, FASLG, FGB, FGG, FOXA3, GCH1, GNA12, GPAM, GRB14, GYS2, GZMA, HAMP, HAO1, HMGCS2, HPX, HRG, IGF1R, IGFBP1, IL18R1, IL18RAP, IL1RN, IL6R, INSIG1, ITK, KIF22, KIR2DL3, KIR2DL4, KLKB1, LECT2, LEPR, MAFG, MLL2, MS4A1, NCR1, NEDD4, NR1H4, NR1I2, ORM1, PGLYRP2, POLE2, PON1, PON3, PPARD, PRDX6, PRF1, PRG4, RAD23B, RTP3, RTP4, SDS, SERPINA10, SERPINA7, SERPINC1, SERPIND1, SLC25A13, SLC45A2, SORT1, SRD5A2, SULT1B1, TAT, TBX21, TM4SF4, TP53BP1, TRIB1, TRPM8, TTPA, UNG, XBP1	2527	response to stimulus
GO:0016054	4.172e-07	2.462	16 ACOX1, ACSL5, AKR1D1, AMDHD1, ARG1, CYP39A1, HAL, HAO1, PON1, PON3, PPARD, SDS, SULT2A1, TAT, TDO2, UROC1	96	organic acid catabolic process
GO:0046395	4.172e-07	2.462	16 ACOX1, ACSL5, AKR1D1, AMDHD1, ARG1, CYP39A1, HAL, HAO1, PON1, PON3, PPARD, SDS, SULT2A1, TAT, TDO2, UROC1	96	carboxylic acid catabolic process
GO:0042221	2.411e-06	29.5	61 ABCG5, ACSL5, ADH6, AGTR1, AGXT, APCS, APOB, AQP9, BCHE, C5, CCR2, CD4, CFTR, CPB2, CREB3L3, CTPS, CXCL2, CYP1A2, CYP2C8, DHRS2, EI24, ENPP1, EPHX1, F7, FASLG, FGB, FGG, GCH1, GPAM, GRB14, GYS2, HAO1, HMGCS2, HPX, IGF1R, IGFBP1, IL1RN, IL6R, LECT2, LEPR, MLL2, NEDD4, NR1H4, NR1I2, PON1, PPARD, PRDX6, PRF1, RTP3, RTP4, SDS, SERPINA7, SERPINC1, SERPIND1, SLC25A13, SORT1, SRD5A2, SULT1B1, TAT, TRIB1, TTPA	1150	response to chemical stimulus
GO:0007596	2.985e-06	2.488	15 C4BPB, C9, CPB2, F10, F11, F2, F7, F9, FGB, FGG, GNA12, HRG, KLKB1, SERPINC1, SERPIND1	97	blood coagulation
GO:0002541	3.616e-06	0.7438	9 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFH, KLKB1	29	activation of plasma proteins involved in acute inflammatory response
GO:0050817	3.850e-06	2.539	15 C4BPB, C9, CPB2, F10, F11, F2, F7, F9, FGB, FGG, GNA12, HRG, KLKB1, SERPINC1, SERPIND1	99	coagulation
GO:0007599	5.584e-06	2.616	15 C4BPB, C9, CPB2, F10, F11, F2, F7, F9, FGB, FGG, GNA12, HRG, KLKB1, SERPINC1, SERPIND1	102	hemostasis
GO:0002526	9.290e-06	2.001	13 APCS, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFH, F2, IL6R, KLKB1, ORM1	78	acute inflammatory response
GO:0042060	1.051e-05	4.437	19 C4BPB, C9, CPB2, F10, F11, F2, F7, F9, FGB, FGG, GNA12, HRG, IGFBP1, KLKB1, PPARD, SERPINA10, SERPINC1, SERPIND1, TM4SF4	173	wound healing
GO:0006958	1.236e-05	0.436	7 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9	17	complement activation, classical pathway
GO:0006957	1.302e-05	0.2821	6 C5, C8A, C8B, C8G, C9, CFH	11	complement activation, alternative pathway
GO:0016125	1.603e-05	2.103	13 AKR1D1, APOB, APOC1, APOC3, CFTR, CYP39A1, HMGCS2, INSIG1, LEPR, LIPC, NPC1L1, PPARD, SIGMAR1	82	sterol metabolic process
GO:0006955	1.641e-05	13.36	35 AMBP, AQP9, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CCR2, CD247, CD4, CFH, CNPY3, CXCL2, ENPP1, FASLG, GCH1, GPAM, GZMA, HAMP, HPX, IGF1R, IL18R1, IL18RAP, IL1RN, IL6R, KIR2DL3, MS4A1, NCR1, PGLYRP2, PRG4, TBX21, UNG, XBP1	521	immune response
GO:0019835	1.861e-05	0.4617	7 C5, C8A, C8B, C8G, C9, GZMA, PRF1	18	cytolysis
GO:0044281	1.889e-05	33.68	64 ACOT12, ACOX1, ACSL5, ADH4, ADH6, ADK, AGXT, AKR1D1, AMDHD1, APOB, APOC1, APOC3, ARG1, ART4, ASPG, BAAT, BCHE, CCR2, CFTR, CTPS, CYP1A2, CYP2C8, CYP39A1, DHTKD1, ENPP1, GCH1, GNE, GNMT, GNPNAT1, GPAM, GYS2, HAL, HAO1, HMGCS2, HPGD, INSIG1, LEPR, LIPC, MAT1A, MOGAT1, MOGAT3, NPC1L1, NR1H4, NR5A2, NUDT5, OTC, PDX1, PON1, PON3, PPARD, PYGL, SDS, SIGMAR1, SLC25A13, SLC25A15, SLC35D1, SULT1B1, SULT2A1, TAT, TDO2, TMEM195, TTPA, UGP2, UROC1	1313	small molecule metabolic process
GO:0006629	1.898e-05	17.95	42 ACOT12, ACOX1, ACSL5, ADH4, AGTR1, AKR1D1, APOB, APOC1, APOC3, ASPG, BAAT, CFTR, CYP1A2, CYP39A1, DHRS2, GNE, GPAM, HAO1, HMGCS2, HPGD, HSD11B1, INSIG1, LEPR, LIPC, MOGAT1, MOGAT3, MTTP, NPC1L1, NR1H4, NR1I2, NR5A2, PON1, PPARD, PRDX6, RDH16, SCP2, SIGMAR1, SRD5A2, SULT1B1, SULT2A1, TMEM195, TTPA	700	lipid metabolic process
GO:0002455	1.930e-05	0.6669	8 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, HPX	26	humoral immune response mediated by circulating immunoglobulin
GO:0006956	1.930e-05	0.6669	8 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFH	26	complement activation
GO:0032787	2.107e-05	7.156	24 ACOT12, ACOX1, ACSL5, AGXT, AKR1D1, APOC1, APOC3, BAAT, CYP1A2, CYP39A1, GCH1, GNMT, GPAM, HAO1, HPGD, LIPC, NR1H4, NR5A2, PPARD, SDS, SLC35D1, SULT2A1, TMEM195, UGP2	279	monocarboxylic acid metabolic process
GO:0044106	2.291e-05	6.156	22 AGXT, AMDHD1, APOC1, ARG1, ART4, ASPG, BAAT, BCHE, CTPS, GCH1, GNMT, HAL, LIPC, MAT1A, OTC, PON1, SDS, SLC25A15, SULT1B1, TAT, TDO2, UROC1	240	cellular amine metabolic process
GO:0009308	2.340e-05	8.284	26 AGXT, AMDHD1, APOC1, ARG1, ART4, ASPG, BAAT, BCHE, CTPS, GCH1, GNMT, HAL, ITIH1, ITIH3, LIPC, MAT1A, OTC, PGLYRP2, PON1, SDS, SLC25A15, SLC35D1, SULT1B1, TAT, TDO2, UROC1	323	amine metabolic process
GO:0009611	3.907e-05	12.67	33 AGTR1, APCS, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CCR2, CFH, CPB2, CXCL2, F10, F11, F2, F7, F9, FGB, FGG, GNA12, HRG, IGFBP1, IL18RAP, IL1RN, IL6R, KLKB1, ORM1, PPARD, SERPINA10, SERPINC1, SERPIND1, TM4SF4	494	response to wounding
GO:0008203	4.445e-05	1.949	12 AKR1D1, APOB, APOC1, APOC3, CFTR, CYP39A1, HMGCS2, INSIG1, LEPR, LIPC, NPC1L1, PPARD	76	cholesterol metabolic process
GO:0006950	9.585e-05	37.01	66 AGTR1, ALB, AMBP, APCS, AQP9, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CCR2, CFH, CIDEB, CLEC1B, CNPY3, CPB2, CREB3L3, CXCL2, DHRS2, ERRFI1, F10, F11, F2, F7, F9, FASLG, FGB, FGG, FOXA3, GCH1, GNA12, GPAM, HAMP, HAO1, HPX, HRG, IGFBP1, IL18R1, IL18RAP, IL1RN, IL6R, INSIG1, ITK, KIF22, KIR2DL4, KLKB1, NCR1, NEDD4, ORM1, PGLYRP2, POLE2, PPARD, PRDX6, PRF1, RAD23B, SERPINA10, SERPINC1, SERPIND1, TAT, TM4SF4, TP53BP1, TRIB1, TRPM8, UNG	1443	response to stress
GO:0002376	1.491e-04	21.01	44 ADK, AMBP, AQP9, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CCR2, CD247, CD3D, CD4, CFH, CNPY3, CXCL2, DHRS2, ENPP1, F7, FASLG, GCH1, GPAM, GZMA, HAMP, HPX, IGF1R, IL18R1, IL18RAP, IL1RN, IL6R, ITIH1, KIR2DL3, MS4A1, NCK2, NCR1, ORM1, PGLYRP2, PRG4, PTPN22, SLC25A38, TBX21, UNG, XBP1	819	immune system process
GO:0006519	1.762e-04	7.053	22 AGXT, AMDHD1, APOC1, ARG1, ART4, ASPG, BAAT, BCHE, CTPS, GCH1, GNMT, HAL, LIPC, MAT1A, OTC, PON1, SDS, SLC25A15, SULT1B1, TAT, TDO2, UROC1	275	cellular amino acid and derivative metabolic process
GO:0051917	1.935e-04	0.2565	5 CPB2, F11, F2, HRG, KLKB1	10	regulation of fibrinolysis
GO:0051605	3.001e-04	1.616	10 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFH, F11, KLKB1	63	protein maturation by peptide bond cleavage
GO:0017144	3.228e-04	0.2821	5 BCHE, CYP1A2, CYP2C8, FMO3, NR1I2	11	drug metabolic process
GO:0008206	3.976e-04	0.4873	6 AKR1D1, BAAT, CYP39A1, NR1H4, NR5A2, SULT2A1	19	bile acid metabolic process
GO:0016042	4.406e-04	3.822	15 ACOX1, ACSL5, AKR1D1, APOB, APOC1, APOC3, ASPG, CYP1A2, CYP39A1, HAO1, LIPC, PPARD, PRDX6, SRD5A2, SULT2A1	149	lipid catabolic process
GO:0016064	4.831e-04	1.359	9 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, HPX, TBX21	53	immunoglobulin mediated immune response
GO:0019724	5.557e-04	1.385	9 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, HPX, TBX21	54	B cell mediated immunity
GO:0016485	6.109e-04	2.154	11 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFH, F11, IFT172, KLKB1	84	protein processing
GO:0006952	6.908e-04	13.39	31 AGTR1, APCS, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CCR2, CFH, CLEC1B, CNPY3, CXCL2, F2, GCH1, GPAM, HAMP, HPX, IL18R1, IL18RAP, IL1RN, IL6R, ITK, KIR2DL4, KLKB1, NCR1, ORM1, PGLYRP2, PRF1, SERPINC1	522	defense response
GO:0015918	7.341e-04	1.103	8 ABCG5, APOB, APOC1, APOC3, CFTR, LIPC, NPC1L1, PON1	43	sterol transport
GO:0030301	7.341e-04	1.103	8 ABCG5, APOB, APOC1, APOC3, CFTR, LIPC, NPC1L1, PON1	43	cholesterol transport
GO:0002684	7.486e-04	5.566	18 ADK, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD247, CD4, CFH, F7, GPAM, HPX, IL6R, NCK2, PTPN22, TBX21	217	positive regulation of immune system process
GO:0042730	7.554e-04	0.3334	5 CPB2, F11, F2, HRG, KLKB1	13	fibrinolysis
GO:0044248	7.741e-04	18.98	39 ACOX1, ACSL5, AKR1D1, AMBP, AMDHD1, APOB, APOC1, APOC3, ARG1, CYP1A2, CYP2C8, CYP39A1, DCPS, DNASE1L3, ENPP1, EPHX1, ERLIN1, FBXL4, GCH1, GZMA, HAL, HAO1, LIPC, NEDD4, NR1I2, NUDT5, PON1, PON3, PPARD, PRDX6, RAD23B, SDS, SIAH2, SULT2A1, TAT, TDO2, TRIB1, UROC1, ZCCHC6	740	cellular catabolic process
GO:0050878	9.851e-04	4.129	15 C4BPB, C9, CPB2, F10, F11, F2, F7, F9, FGB, FGG, GNA12, HRG, KLKB1, SERPINC1, SERPIND1	161	regulation of body fluid levels
GO:0051604	9.854e-04	2.283	11 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFH, F11, IFT172, KLKB1	89	protein maturation
GO:0030573	1.026e-03	0.07695	3 AKR1D1, CYP39A1, SULT2A1	3	bile acid catabolic process
GO:0042737	1.026e-03	0.07695	3 CYP1A2, CYP2C8, NR1I2	3	drug catabolic process
GO:0042738	1.026e-03	0.07695	3 CYP1A2, CYP2C8, NR1I2	3	exogenous drug catabolic process
GO:0051005	1.026e-03	0.07695	3 APOC1, APOC3, SORT1	3	negative regulation of lipoprotein lipase activity
GO:0006520	1.058e-03	4.668	16 AGXT, AMDHD1, ARG1, ART4, ASPG, BAAT, CTPS, GNMT, HAL, MAT1A, OTC, SDS, SLC25A15, TAT, TDO2, UROC1	182	cellular amino acid metabolic process
GO:0045087	1.190e-03	4.206	15 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFH, CNPY3, GCH1, HPX, IL18R1, IL18RAP, NCR1, PGLYRP2	164	innate immune response
GO:0009056	1.312e-03	23.9	45 ACOX1, ACSL5, ADH4, AKR1D1, AMBP, AMDHD1, APOB, APOC1, APOC3, ARG1, ASPG, CYP1A2, CYP2C8, CYP39A1, DCPS, DHTKD1, DNASE1L3, ENPP1, EPHX1, ERLIN1, FBXL4, GCH1, GZMA, HAL, HAO1, LIPC, NEDD4, NR1I2, NUDT5, PGLYRP2, PON1, PON3, PPARD, PRDX6, PYGL, RAD23B, SDS, SIAH2, SRD5A2, SULT2A1, TAT, TDO2, TRIB1, UROC1, ZCCHC6	932	catabolic process
GO:0018904	1.313e-03	1.205	8 ACSL5, APOB, APOC1, APOC3, CYP1A2, GPAM, LIPC, TMEM195	47	organic ether metabolic process
GO:0006959	1.496e-03	1.59	9 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFH, HPX	62	humoral immune response
GO:0034367	2.010e-03	0.4104	5 AGTR1, APOB, APOC1, APOC3, LIPC	16	macromolecular complex remodeling
GO:0034368	2.010e-03	0.4104	5 AGTR1, APOB, APOC1, APOC3, LIPC	16	protein-lipid complex remodeling
GO:0034369	2.010e-03	0.4104	5 AGTR1, APOB, APOC1, APOC3, LIPC	16	plasma lipoprotein particle remodeling
GO:0002253	2.111e-03	2.078	10 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD247, CFH, PTPN22	81	activation of immune response
GO:0046503	2.495e-03	0.2308	4 APOB, APOC1, APOC3, LIPC	9	glycerolipid catabolic process
GO:0019439	2.627e-03	0.436	5 EPHX1, PON1, PON3, TAT, TDO2	17	aromatic compound catabolic process
GO:0044242	2.783e-03	1.744	9 ACOX1, ACSL5, APOB, APOC1, APOC3, HAO1, LIPC, PPARD, PRDX6	68	cellular lipid catabolic process
GO:0048583	2.950e-03	11.26	26 AGTR1, AMBP, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD247, CFH, CPB2, ENPP1, F11, F2, F7, GRB14, HPX, HRG, IL6R, KLKB1, NCR1, PTPN22, SERPINC1, TBX21, TRIB1	439	regulation of response to stimulus
GO:0032372	3.221e-03	0.1026	3 ABCG5, APOC1, APOC3	4	negative regulation of sterol transport
GO:0032375	3.221e-03	0.1026	3 ABCG5, APOC1, APOC3	4	negative regulation of cholesterol transport
GO:0060192	3.221e-03	0.1026	3 APOC1, APOC3, SORT1	4	negative regulation of lipase activity
GO:0006694	3.246e-03	2.206	10 AKR1D1, APOB, CFTR, CYP39A1, HMGCS2, HSD11B1, NPC1L1, SCP2, SIGMAR1, SRD5A2	86	steroid biosynthetic process
GO:0006706	3.396e-03	0.4617	5 AKR1D1, CYP1A2, CYP39A1, SRD5A2, SULT2A1	18	steroid catabolic process
GO:0002449	3.534e-03	2.231	10 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, HPX, NCR1, TBX21	87	lymphocyte mediated immunity
GO:0002443	3.928e-03	2.719	11 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, HPX, IL6R, NCR1, TBX21	106	leukocyte mediated immunity
GO:0065008	3.957e-03	34.73	57 ABCG5, ADH4, AGTR1, AKR1D1, ALB, ANKRD11, APOB, APOC3, AQP9, C4BPB, C9, CCR2, CD4, CFTR, CPB2, DHRS2, DSG1, EI24, ENPP1, F10, F11, F2, F7, F9, FASLG, FGB, FGG, FOXA3, GCH1, GCKR, GNA11, GNA12, GPAM, HAMP, HPX, HRG, IGFBP1, KLKB1, LIPC, MAFG, NCK2, NPC1L1, NR5A2, OTC, PDX1, PPARD, PRDX4, PRDX6, PYGL, SERPINC1, SERPIND1, SLC16A2, SLC25A38, SRD5A2, SULT1B1, TRPM8, TXNL1	1354	regulation of biological quality
GO:0002252	4.059e-03	4.232	14 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFH, GPAM, HPX, IL6R, NCR1, TBX21, UNG	165	immune effector process
GO:0030193	4.409e-03	0.7695	6 CPB2, F11, F2, F7, HRG, KLKB1	30	regulation of blood coagulation
GO:0044282	4.646e-03	8.387	21 ACOX1, ACSL5, ADH4, AKR1D1, AMDHD1, ARG1, CYP39A1, DHTKD1, ENPP1, GCH1, HAL, HAO1, NUDT5, PON1, PON3, PPARD, SDS, SULT2A1, TAT, TDO2, UROC1	327	small molecule catabolic process
GO:0010033	4.712e-03	17.95	35 ACSL5, ADH6, AGXT, APCS, APOB, AQP9, BCHE, CD4, CFTR, CREB3L3, ENPP1, EPHX1, F7, FASLG, GCH1, GPAM, GRB14, GYS2, HMGCS2, HPX, IGF1R, IGFBP1, IL1RN, IL6R, LEPR, MLL2, NR1H4, PPARD, PRF1, SDS, SERPINA7, SORT1, SRD5A2, TAT, TRIB1	700	response to organic substance
GO:0010876	4.904e-03	3.796	13 ABCG5, ACSL5, APOB, APOC1, APOC3, CFTR, ENPP1, LIPC, NPC1L1, PON1, PPARD, SCP2, SIGMAR1	148	lipid localization
GO:0009605	5.005e-03	13.75	29 ABCG5, ACSL5, AGTR1, ALB, BCHE, C5, CCR2, CPB2, CXCL2, F11, F2, F7, FOXA3, GPAM, HMGCS2, HRG, IGF1R, IL6R, KLKB1, LECT2, LEPR, PGLYRP2, PON1, PON3, SDS, SERPINA7, SERPINC1, SERPIND1, TTPA	536	response to external stimulus
GO:0055088	5.153e-03	1.129	7 ABCG5, APOB, APOC3, GPAM, LIPC, NPC1L1, NR5A2	44	lipid homeostasis
GO:0030194	5.399e-03	0.2821	4 CPB2, F2, F7, HRG	11	positive regulation of blood coagulation
GO:0002682	5.542e-03	8.515	21 ADK, AMBP, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD247, CD4, CFH, F7, GPAM, HPX, IL6R, NCK2, NCR1, ORM1, PTPN22, TBX21	332	regulation of immune system process
GO:0006662	5.812e-03	1.154	7 ACSL5, APOB, APOC1, APOC3, GPAM, LIPC, TMEM195	45	glycerol ether metabolic process
GO:0007598	6.774e-03	0.1282	3 F10, F7, F9	5	blood coagulation, extrinsic pathway
GO:0034382	6.774e-03	0.1282	3 APOC1, APOC3, LIPC	5	chylomicron remnant clearance
GO:0006869	6.938e-03	3.437	12 ABCG5, ACSL5, APOB, APOC1, APOC3, CFTR, LIPC, NPC1L1, PON1, PPARD, SCP2, SIGMAR1	134	lipid transport
GO:0050818	6.968e-03	0.8464	6 CPB2, F11, F2, F7, HRG, KLKB1	33	regulation of coagulation
GO:0061041	6.968e-03	0.8464	6 CPB2, F11, F2, F7, HRG, KLKB1	33	regulation of wound healing
GO:0030195	7.998e-03	0.5643	5 CPB2, F11, F2, HRG, KLKB1	22	negative regulation of blood coagulation
GO:0042632	8.032e-03	0.8721	6 ABCG5, APOB, APOC3, LIPC, NPC1L1, NR5A2	34	cholesterol homeostasis
GO:0055092	8.032e-03	0.8721	6 ABCG5, APOB, APOC3, LIPC, NPC1L1, NR5A2	34	sterol homeostasis
GO:0043434	9.264e-03	4.104	13 ACSL5, CFTR, ENPP1, F7, GPAM, GRB14, HMGCS2, IGF1R, IGFBP1, IL6R, SERPINA7, SORT1, SRD5A2	160	response to peptide hormone stimulus
GO:0050819	9.561e-03	0.5899	5 CPB2, F11, F2, HRG, KLKB1	23	negative regulation of coagulation
GO:0050820	9.731e-03	0.3334	4 CPB2, F2, F7, HRG	13	positive regulation of coagulation
GO:0000050	1.153e-02	0.1539	3 ARG1, OTC, SLC25A15	6	urea cycle
GO:0019433	1.153e-02	0.1539	3 APOB, APOC3, LIPC	6	triglyceride catabolic process
GO:0019627	1.153e-02	0.1539	3 ARG1, OTC, SLC25A15	6	urea metabolic process
GO:0034379	1.153e-02	0.1539	3 APOB, APOC1, APOC3	6	very-low-density lipoprotein particle assembly
GO:0044269	1.153e-02	0.1539	3 APOB, APOC3, LIPC	6	glycerol ether catabolic process
GO:0046461	1.153e-02	0.1539	3 APOB, APOC3, LIPC	6	neutral lipid catabolic process
GO:0046464	1.153e-02	0.1539	3 APOB, APOC3, LIPC	6	acylglycerol catabolic process
GO:0015711	1.170e-02	0.949	6 CFTR, SLC10A1, SLC13A5, SLC25A13, SLCO1B1, SLCO1B3	37	organic anion transport
GO:0055114	1.180e-02	11.82	25 ACOX1, ADH4, ADH6, AKR1D1, ALDH1A1, CYP1A2, CYP2C8, CYP39A1, CYP3A43, DHRS2, DHTKD1, FMO3, FMO5, HAO1, HPGD, HSD11B1, HSD17B13, PRDX4, PRDX6, RDH16, SLC25A13, SRD5A2, TDO2, TMEM195, TXNL1	461	oxidation reduction
GO:0050778	1.211e-02	3.18	11 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD247, CFH, HPX, PTPN22	124	positive regulation of immune response
GO:0006954	1.288e-02	7.9	19 AGTR1, APCS, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CCR2, CFH, CXCL2, F2, IL18RAP, IL1RN, IL6R, KLKB1, ORM1, SERPINC1	308	inflammatory response
GO:0008610	1.288e-02	7.9	19 ACSL5, AKR1D1, APOB, APOC1, APOC3, CFTR, CYP39A1, GNE, GPAM, HMGCS2, HSD11B1, LIPC, MOGAT1, MOGAT3, NPC1L1, SCP2, SIGMAR1, SRD5A2, TMEM195	308	lipid biosynthetic process
GO:0006641	1.320e-02	0.9746	6 ACSL5, APOB, APOC1, APOC3, GPAM, LIPC	38	triglyceride metabolic process
GO:0009064	1.320e-02	0.9746	6 AMDHD1, ARG1, ART4, CTPS, OTC, TAT	38	glutamine family amino acid metabolic process
GO:0009063	1.338e-02	1.359	7 AMDHD1, ARG1, HAL, SDS, TAT, TDO2, UROC1	53	cellular amino acid catabolic process
GO:0050776	1.451e-02	4.925	14 AMBP, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD247, CFH, HPX, NCR1, PTPN22, TBX21	192	regulation of immune response
GO:0048878	1.610e-02	11.44	24 ABCG5, AGTR1, APOB, APOC3, AQP9, CCR2, ENPP1, F2, FASLG, FOXA3, GCKR, GNA11, GPAM, HAMP, HPX, LIPC, MAFG, NPC1L1, NR5A2, OTC, PDX1, PPARD, PYGL, TRPM8	446	chemical homeostasis
GO:0043604	1.773e-02	0.1795	3 ARG1, OTC, SLC25A15	7	amide biosynthetic process
GO:0051918	1.773e-02	0.1795	3 CPB2, F2, HRG	7	negative regulation of fibrinolysis
GO:0031667	1.854e-02	5.078	14 ABCG5, ACSL5, ALB, BCHE, F7, FOXA3, GPAM, HMGCS2, IGF1R, LEPR, SDS, SERPINA7, SERPINC1, TTPA	198	response to nutrient levels
GO:0002460	1.962e-02	2.385	9 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, HPX, TBX21	93	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0046942	2.041e-02	3.437	11 ACSL5, AGXT, AQP9, PPARD, SLC10A1, SLC13A5, SLC16A2, SLC25A13, SLC25A15, SLC38A4, SLC43A1	134	carboxylic acid transport
GO:0006639	2.042e-02	1.077	6 ACSL5, APOB, APOC1, APOC3, GPAM, LIPC	42	acylglycerol metabolic process
GO:0001897	2.055e-02	0.0513	2 ALB, C9	2	cytolysis by symbiont of host cells
GO:0001907	2.055e-02	0.0513	2 ALB, C9	2	killing by symbiont of host cells
GO:0019836	2.055e-02	0.0513	2 ALB, C9	2	hemolysis by symbiont of host erythrocytes
GO:0034638	2.055e-02	0.0513	2 APOC1, LIPC	2	phosphatidylcholine catabolic process
GO:0042866	2.055e-02	0.0513	2 AGXT, SDS	2	pyruvate biosynthetic process
GO:0044004	2.055e-02	0.0513	2 ALB, C9	2	disruption by symbiont of host cells
GO:0044179	2.055e-02	0.0513	2 ALB, C9	2	hemolysis of cells in other organism
GO:0051715	2.055e-02	0.0513	2 ALB, C9	2	cytolysis of cells of another organism
GO:0051801	2.055e-02	0.0513	2 ALB, C9	2	cytolysis of cells in other organism involved in symbiotic interaction
GO:0052025	2.055e-02	0.0513	2 ALB, C9	2	modification by symbiont of host cell membrane
GO:0052043	2.055e-02	0.0513	2 ALB, C9	2	modification by symbiont of host cellular component
GO:0052111	2.055e-02	0.0513	2 ALB, C9	2	modification by symbiont of host structure
GO:0052185	2.055e-02	0.0513	2 ALB, C9	2	modification of structure of other organism involved in symbiotic interaction
GO:0052188	2.055e-02	0.0513	2 ALB, C9	2	modification of cellular component in other organism involved in symbiotic interaction
GO:0052331	2.055e-02	0.0513	2 ALB, C9	2	hemolysis of cells in other organism involved in symbiotic interaction
GO:0052332	2.055e-02	0.0513	2 ALB, C9	2	modification by organism of cell membrane in other organism involved in symbiotic interaction
GO:0009310	2.073e-02	1.488	7 AMDHD1, ARG1, HAL, SDS, TAT, TDO2, UROC1	58	amine catabolic process
GO:0015849	2.129e-02	3.463	11 ACSL5, AGXT, AQP9, PPARD, SLC10A1, SLC13A5, SLC16A2, SLC25A13, SLC25A15, SLC38A4, SLC43A1	135	organic acid transport
GO:0002250	2.191e-02	2.437	9 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, HPX, TBX21	95	adaptive immune response
GO:0006638	2.235e-02	1.103	6 ACSL5, APOB, APOC1, APOC3, GPAM, LIPC	43	neutral lipid metabolic process
GO:0005976	2.318e-02	2.462	9 ENPP1, GNE, GNMT, GYS2, ITIH1, ITIH3, PGLYRP2, PYGL, SLC35D1	96	polysaccharide metabolic process
GO:0005975	2.423e-02	11.18	23 ALG5, ALG8, DHTKD1, ENPP1, GNE, GNMT, GNPNAT1, GYS2, ITIH1, ITIH3, MOGAT1, MOGAT3, MPDU1, NR1H4, NUDT5, PDX1, PGLYRP2, PPARD, PYGL, SDS, SLC2A2, SLC35D1, UGP2	436	carbohydrate metabolic process
GO:0016053	2.436e-02	3.54	11 AGXT, AKR1D1, APOC1, APOC3, CYP39A1, LIPC, OTC, SDS, SLC35D1, TMEM195, UGP2	138	organic acid biosynthetic process
GO:0046394	2.436e-02	3.54	11 AGXT, AKR1D1, APOC1, APOC3, CYP39A1, LIPC, OTC, SDS, SLC35D1, TMEM195, UGP2	138	carboxylic acid biosynthetic process
GO:0009991	3.096e-02	5.463	14 ABCG5, ACSL5, ALB, BCHE, F7, FOXA3, GPAM, HMGCS2, IGF1R, LEPR, SDS, SERPINA7, SERPINC1, TTPA	213	response to extracellular stimulus
GO:0032371	3.167e-02	0.4873	4 ABCG5, APOC1, APOC3, PON1	19	regulation of sterol transport
GO:0032374	3.167e-02	0.4873	4 ABCG5, APOC1, APOC3, PON1	19	regulation of cholesterol transport
GO:0034381	3.167e-02	0.4873	4 APOB, APOC1, APOC3, LIPC	19	lipoprotein particle clearance
GO:0006778	3.187e-02	0.8208	5 ALAS1, AMBP, CYP1A2, HPX, SLC25A38	32	porphyrin metabolic process
GO:0033013	3.187e-02	0.8208	5 ALAS1, AMBP, CYP1A2, HPX, SLC25A38	32	tetrapyrrole metabolic process
GO:0006548	3.242e-02	0.2308	3 AMDHD1, HAL, UROC1	9	histidine catabolic process
GO:0009077	3.242e-02	0.2308	3 AMDHD1, HAL, UROC1	9	histidine family amino acid catabolic process
GO:0034374	3.242e-02	0.2308	3 AGTR1, APOB, LIPC	9	low-density lipoprotein particle remodeling
GO:0007586	3.366e-02	1.667	7 ABCG5, AKR1D1, BAAT, CYP39A1, NPC1L1, SULT2A1, TFF2	65	digestion
GO:0014065	3.673e-02	0.513	4 F2, IGF1R, NEDD4, PPARD	20	phosphoinositide 3-kinase cascade
GO:0005996	3.762e-02	5.001	13 DHTKD1, ENPP1, GNE, GNMT, GNPNAT1, GYS2, NUDT5, PDX1, PPARD, PYGL, SDS, SLC35D1, UGP2	195	monosaccharide metabolic process
GO:0016126	3.899e-02	0.8721	5 APOB, CFTR, HMGCS2, NPC1L1, SIGMAR1	34	sterol biosynthetic process
GO:0090207	4.144e-02	0.2565	3 ACSL5, APOC3, GPAM	10	regulation of triglyceride metabolic process
GO:0016051	4.217e-02	2.77	9 ENPP1, GNE, GNMT, GYS2, MPDU1, PYGL, SDS, SLC35D1, UGP2	108	carbohydrate biosynthetic process
GO:0042058	4.220e-02	0.5386	4 ERRFI1, FASLG, NCK2, ZGPAT	21	regulation of epidermal growth factor receptor signaling pathway
GO:0032368	4.317e-02	0.8977	5 ABCG5, ACSL5, APOC1, APOC3, PON1	35	regulation of lipid transport
GO:0051241	4.441e-02	3.924	11 ABCG5, APOC1, APOC3, BCHE, CPB2, ENPP1, F11, F2, HRG, IL6R, KLKB1	153	negative regulation of multicellular organismal process
GO:0006065	4.456e-02	0.07695	2 SLC35D1, UGP2	3	UDP-glucuronate biosynthetic process
GO:0006067	4.456e-02	0.07695	2 ADH4, ADH6	3	ethanol metabolic process
GO:0006069	4.456e-02	0.07695	2 ADH4, ADH6	3	ethanol oxidation
GO:0009820	4.456e-02	0.07695	2 BCHE, CYP1A2	3	alkaloid metabolic process
GO:0010915	4.456e-02	0.07695	2 APOC1, APOC3	3	regulation of very-low-density lipoprotein particle clearance
GO:0010916	4.456e-02	0.07695	2 APOC1, APOC3	3	negative regulation of very-low-density lipoprotein particle clearance
GO:0034308	4.456e-02	0.07695	2 ADH4, ADH6	3	monohydric alcohol metabolic process
GO:0046399	4.456e-02	0.07695	2 SLC35D1, UGP2	3	glucuronate biosynthetic process
GO:0051919	4.456e-02	0.07695	2 F11, KLKB1	3	positive regulation of fibrinolysis
GO:0009725	4.719e-02	9.157	19 ACSL5, AGXT, BCHE, CFTR, ENPP1, F7, GPAM, GRB14, HMGCS2, IGF1R, IGFBP1, IL1RN, IL6R, LEPR, MLL2, SERPINA7, SORT1, SRD5A2, TAT	357	response to hormone stimulus
GO:0044262	4.819e-02	8.49	18 ALG5, ALG8, DHTKD1, ENPP1, GNE, GNMT, GNPNAT1, GYS2, MOGAT1, MOGAT3, MPDU1, NUDT5, PDX1, PPARD, PYGL, SDS, SLC35D1, UGP2	331	cellular carbohydrate metabolic process
GO:0006725	4.821e-02	2.847	9 CYP1A2, EPHX1, GCH1, GNMT, PON1, PON3, SULT1B1, TAT, TDO2	111	cellular aromatic compound metabolic process

Id	Pvalue	ExpCount	Count	Size	Term
GO:0042598	2.145e-06	4.286	19 AMBP, APOB, AQP9, CYP1A2, CYP2C8, CYP39A1, CYP3A43, EPHX1, F10, F7, FMO3, FMO5, GRB14, IGF1R, PON1, PON3, RDH16, SORT1, SRD5A2	169	vesicular fraction
GO:0005576	2.919e-06	35.68	68 AFM, ALB, AMBP, APCS, APOB, APOC1, APOC3, BCHE, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD200R1, CFH, COLEC10, CPB2, CXCL2, ENPP1, F10, F11, F2, F7, F9, FASLG, FCRLA, FETUB, FGB, FGG, GC, GZMA, HAMP, HPX, HRG, HSD17B13, IGFBP1, IL1RN, IL6R, INHBC, ITIH1, ITIH3, KLKB1, LECT2, LEPR, LIPC, LOC55908, LRG1, ORM1, PGLYRP2, PON1, PON3, PRDX4, PRF1, PRG4, SERPINA10, SERPINA11, SERPINA4, SERPINA7, SERPINA9, SERPINC1, SERPIND1, SLPI, SPP2, TCN1, TFF2, TTR	1407	extracellular region
GO:0005615	5.506e-06	13.92	36 AFM, ALB, APCS, APOB, APOC1, APOC3, BCHE, C5, C8A, C8B, CFH, CPB2, CXCL2, ENPP1, F11, F2, F7, FASLG, FGB, FGG, GC, HPX, IGFBP1, IL1RN, IL6R, KLKB1, LECT2, LEPR, LIPC, ORM1, PON1, PON3, PRDX4, SERPINA4, SERPINA7, SERPINC1	549	extracellular space
GO:0005792	5.872e-06	4.134	18 AMBP, APOB, AQP9, CYP1A2, CYP2C8, CYP39A1, CYP3A43, EPHX1, F10, FMO3, FMO5, GRB14, IGF1R, PON1, PON3, RDH16, SORT1, SRD5A2	163	microsome
GO:0005579	7.459e-06	0.1775	5 C5, C8A, C8B, C8G, C9	7	membrane attack complex
GO:0000267	2.583e-04	20.92	42 ABCG5, AMBP, APOB, AQP9, BCHE, CCR2, CXCL2, CYP1A2, CYP2C8, CYP39A1, CYP3A43, EBNA1BP2, EPHX1, F10, F2, F7, FGB, FMO3, FMO5, GNA11, GNPNAT1, GRB14, GYS2, HAL, IGF1R, JTB, PLXNA1, PON1, PON3, PYGL, RDH16, SLC10A1, SLC13A5, SLC16A2, SLC17A2, SLC22A1, SLC22A3, SLC2A2, SLCO1B1, SORT1, SRD5A2, TDO2	825	cell fraction
GO:0044432	4.092e-04	13.04	30 ACSL5, ALG5, ALG8, APOB, AUP1, BCHE, CD4, CFTR, CREB3L3, CYP1A2, CYP2C8, CYP39A1, CYP3A43, EPHX1, ERLIN1, FMO3, FMO5, HSD11B1, INSIG1, JAGN1, MOGAT1, MOGAT3, MPDU1, RDH16, SAR1B, SIGMAR1, SLC35D1, SORT1, SRD5A2, TMED6	514	endoplasmic reticulum part
GO:0005789	4.309e-04	11.77	28 ACSL5, ALG5, ALG8, AUP1, CD4, CFTR, CREB3L3, CYP1A2, CYP2C8, CYP39A1, CYP3A43, EPHX1, ERLIN1, FMO3, FMO5, HSD11B1, INSIG1, JAGN1, MOGAT1, MOGAT3, MPDU1, RDH16, SAR1B, SIGMAR1, SLC35D1, SORT1, SRD5A2, TMED6	464	endoplasmic reticulum membrane
GO:0005626	4.889e-04	15.88	34 ABCG5, AMBP, APOB, AQP9, BCHE, CYP1A2, CYP2C8, CYP39A1, CYP3A43, EBNA1BP2, EPHX1, F10, F7, FMO3, FMO5, GNA11, GRB14, GYS2, IGF1R, JTB, PLXNA1, PON1, PON3, RDH16, SLC10A1, SLC13A5, SLC16A2, SLC17A2, SLC22A1, SLC22A3, SLC2A2, SLCO1B1, SORT1, SRD5A2	626	insoluble fraction
GO:0042175	6.701e-04	12.1	28 ACSL5, ALG5, ALG8, AUP1, CD4, CFTR, CREB3L3, CYP1A2, CYP2C8, CYP39A1, CYP3A43, EPHX1, ERLIN1, FMO3, FMO5, HSD11B1, INSIG1, JAGN1, MOGAT1, MOGAT3, MPDU1, RDH16, SAR1B, SIGMAR1, SLC35D1, SORT1, SRD5A2, TMED6	477	nuclear membrane-endoplasmic reticulum network
GO:0071212	9.039e-04	13.67	30 ACSL5, ALG5, ALG8, APOB, AUP1, BCHE, CD4, CFTR, CREB3L3, CYP1A2, CYP2C8, CYP39A1, CYP3A43, EPHX1, ERLIN1, FMO3, FMO5, HSD11B1, INSIG1, JAGN1, MOGAT1, MOGAT3, MPDU1, RDH16, SAR1B, SIGMAR1, SLC35D1, SORT1, SRD5A2, TMED6	539	subsynaptic reticulum
GO:0044421	1.078e-03	18.74	37 AFM, ALB, APCS, APOB, APOC1, APOC3, BCHE, C5, C8A, C8B, CFH, CPB2, CXCL2, ENPP1, F11, F2, F7, FASLG, FGB, FGG, GC, HPX, IGFBP1, IL1RN, IL6R, KLKB1, LECT2, LEPR, LIPC, ORM1, PON1, PON3, PRDX4, SERPINA4, SERPINA7, SERPINC1, SLPI	739	extracellular region part
GO:0005624	1.185e-03	15.29	32 ABCG5, AMBP, APOB, AQP9, BCHE, CYP1A2, CYP2C8, CYP39A1, CYP3A43, EBNA1BP2, EPHX1, F10, F7, FMO3, FMO5, GNA11, GRB14, IGF1R, JTB, PLXNA1, PON1, PON3, RDH16, SLC10A1, SLC16A2, SLC17A2, SLC22A1, SLC22A3, SLC2A2, SLCO1B1, SORT1, SRD5A2	603	membrane fraction
GO:0032994	2.608e-03	0.5326	5 APOB, APOC1, APOC3, LIPC, PON1	21	protein-lipid complex
GO:0034358	2.608e-03	0.5326	5 APOB, APOC1, APOC3, LIPC, PON1	21	plasma lipoprotein particle
GO:0034364	3.996e-03	0.3297	4 APOC1, APOC3, LIPC, PON1	13	high-density lipoprotein particle
GO:0005783	4.786e-03	19.65	36 ACSL5, ALG5, ALG8, APOB, APOC1, AUP1, BCHE, CD4, CFTR, CNPY3, CREB3L3, CYP1A2, CYP2C8, CYP39A1, CYP3A43, EPHX1, ERLIN1, FMO3, FMO5, HSD11B1, INSIG1, JAGN1, LRG1, MOGAT1, MOGAT3, MPDU1, MTTP, NCK2, RDH16, SAR1B, SIGMAR1, SLC35D1, SORT1, SRD5A2, TMED6, TMEM195	775	endoplasmic reticulum
GO:0042627	7.817e-03	0.1775	3 APOB, APOC1, APOC3	7	chylomicron
GO:0031983	1.506e-02	0.8115	5 ALB, APOB, FGB, FGG, HRG	32	vesicle lumen
GO:0034363	2.252e-02	0.07608	2 APOB, APOC3	3	intermediate-density lipoprotein particle
GO:0042101	2.644e-02	0.279	3 CD247, CD3D, CD4	11	T cell receptor complex
GO:0034361	3.293e-02	0.3043	3 APOB, APOC1, APOC3	12	very-low-density lipoprotein particle
GO:0034385	3.293e-02	0.3043	3 APOB, APOC1, APOC3	12	triglyceride-rich lipoprotein particle
GO:0034366	3.921e-02	0.1014	2 APOC3, PON1	4	spherical high-density lipoprotein particle
GO:0042105	3.921e-02	0.1014	2 CD247, CD3D	4	alpha-beta T cell receptor complex

Id	Pvalue	ExpCount	Count	Size	Term
GO:0004866	2.449e-06	2.503	15 AMBP, C5, FETUB, HRG, ITIH1, ITIH3, SERPINA10, SERPINA11, SERPINA4, SERPINA7, SERPINA9, SERPINC1, SERPIND1, SLPI, SPP2	103	endopeptidase inhibitor activity
GO:0061135	3.540e-06	2.576	15 AMBP, C5, FETUB, HRG, ITIH1, ITIH3, SERPINA10, SERPINA11, SERPINA4, SERPINA7, SERPINA9, SERPINC1, SERPIND1, SLPI, SPP2	106	endopeptidase regulator activity
GO:0030414	4.467e-06	2.625	15 AMBP, C5, FETUB, HRG, ITIH1, ITIH3, SERPINA10, SERPINA11, SERPINA4, SERPINA7, SERPINA9, SERPINC1, SERPIND1, SLPI, SPP2	108	peptidase inhibitor activity
GO:0004867	1.008e-05	1.726	12 AMBP, HRG, ITIH1, ITIH3, SERPINA10, SERPINA11, SERPINA4, SERPINA7, SERPINA9, SERPINC1, SERPIND1, SLPI	71	serine-type endopeptidase inhibitor activity
GO:0004857	1.218e-05	4.569	19 AMBP, APOC1, APOC3, C5, FETUB, GCKR, HRG, ITIH1, ITIH3, SERPINA10, SERPINA11, SERPINA4, SERPINA7, SERPINA9, SERPINC1, SERPIND1, SLPI, SPP2, TRIB1	188	enzyme inhibitor activity
GO:0019842	2.264e-05	2.601	14 ADH4, AGXT, ALAS1, ALB, C8G, DHTKD1, GC, GNMT, MUT, PYGL, SDS, TAT, TCN1, TTPA	107	vitamin binding
GO:0061134	4.538e-05	3.184	15 AMBP, C5, FETUB, HRG, ITIH1, ITIH3, SERPINA10, SERPINA11, SERPINA4, SERPINA7, SERPINA9, SERPINC1, SERPIND1, SLPI, SPP2	131	peptidase regulator activity
GO:0031406	6.378e-04	2.649	12 AGXT, ALB, APOC1, FMO3, GNMT, NEDD4, NR1H4, OTC, PPARD, PYGL, TAT, TDO2	109	carboxylic acid binding
GO:0046943	1.944e-03	1.701	9 AQP9, SLC10A1, SLC13A5, SLC16A2, SLC25A13, SLC25A15, SLC38A4, SLC43A1, SLCO1B3	70	carboxylic acid transmembrane transporter activity
GO:0005342	2.135e-03	1.726	9 AQP9, SLC10A1, SLC13A5, SLC16A2, SLC25A13, SLC25A15, SLC38A4, SLC43A1, SLCO1B3	71	organic acid transmembrane transporter activity
GO:0008289	4.016e-03	7.802	20 ADH4, AKR1D1, ALB, ALDH1A1, APOB, APOC1, APOC3, C8G, DAPP1, F10, GC, MTTP, NR1H4, NR5A2, OTC, PON1, PPARD, PYGL, SCP2, SEC14L3	321	lipid binding
GO:0016597	4.022e-03	1.118	7 AGXT, FMO3, GNMT, NEDD4, OTC, TAT, TDO2	46	amino acid binding
GO:0030246	4.318e-03	6.635	18 APCS, APOB, CD69, CLEC1B, CLEC4G, COLEC10, ENPP1, F11, GNPNAT1, HRG, KLRD1, KLRF1, LIPC, PGLYRP2, PRG4, PYGL, SERPINC1, SERPIND1	273	carbohydrate binding
GO:0005496	5.066e-03	1.167	7 AKR1D1, ALDH1A1, APOC3, GC, NR1H4, PYGL, SCP2	48	steroid binding
GO:0043176	8.543e-03	2.139	9 AGXT, APOC1, BCHE, FMO3, GNMT, NEDD4, OTC, TAT, TDO2	88	amine binding
GO:0016491	9.245e-03	11.76	25 ACOX1, ADH4, ADH6, AKR1D1, ALDH1A1, CYP1A2, CYP2C8, CYP39A1, CYP3A43, DHRS2, DHTKD1, FMO3, FMO5, HAO1, HPGD, HSD11B1, HSD17B13, PRDX4, PRDX6, RDH16, SCP2, SRD5A2, TDO2, TMEM195, TXNL1	484	oxidoreductase activity
GO:0004497	9.321e-03	1.312	7 CYP1A2, CYP2C8, CYP39A1, CYP3A43, FMO3, FMO5, TMEM195	54	monooxygenase activity
GO:0004091	9.353e-03	1.726	8 ACOT12, ASPG, BAAT, BCHE, LIPC, PON1, PON3, PRDX6	71	carboxylesterase activity
GO:0048037	1.046e-02	4.837	14 ACOX1, ADH4, AGXT, ALAS1, ALB, DHTKD1, FMO3, FMO5, HAO1, HPGD, PYGL, SDS, TAT, TGDS	199	cofactor binding
GO:0046906	1.182e-02	1.799	8 AMBP, CYP1A2, CYP2C8, CYP39A1, CYP3A43, MUT, TCN1, TDO2	74	tetrapyrrole binding
GO:0030170	1.506e-02	1.045	6 AGXT, ALAS1, ALB, PYGL, SDS, TAT	43	pyridoxal phosphate binding
GO:0070279	1.506e-02	1.045	6 AGXT, ALAS1, ALB, PYGL, SDS, TAT	43	vitamin B6 binding
GO:0016705	1.535e-02	2.358	9 CYP1A2, CYP2C8, CYP39A1, CYP3A43, FMO3, FMO5, PRDX4, PRDX6, TMEM195	97	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0004063	1.567e-02	0.04861	2 PON1, PON3	2	aryldialkylphosphatase activity
GO:0033695	1.567e-02	0.04861	2 CYP1A2, CYP2C8	2	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor
GO:0034875	1.567e-02	0.04861	2 CYP1A2, CYP2C8	2	caffeine oxidase activity
GO:0016614	2.302e-02	2.042	8 ADH4, ADH6, AKR1D1, DHRS2, HAO1, HPGD, HSD11B1, RDH16	84	oxidoreductase activity, acting on CH-OH group of donors
GO:0019825	2.350e-02	0.4618	4 ALB, CYP1A2, CYP2C8, TDO2	19	oxygen binding
GO:0004060	3.524e-02	0.07292	2 NAT1, NAT2	3	arylamine N-acetyltransferase activity
GO:0004064	3.524e-02	0.07292	2 PON1, PON3	3	arylesterase activity
GO:0015643	3.524e-02	0.07292	2 ALB, DSG1	3	toxin binding
GO:0032052	3.524e-02	0.07292	2 NR1H4, PYGL	3	bile acid binding
GO:0016746	3.927e-02	3.938	11 ALAS1, BAAT, GNPNAT1, GPAM, HMGCS2, MOGAT1, MOGAT3, NAT1, NAT2, SCP2, SRCAP	162	transferase activity, transferring acyl groups
GO:0008514	3.974e-02	0.2674	3 SLCO1B1, SLCO1B3, SLCO2B1	11	organic anion transmembrane transporter activity
GO:0016616	4.058e-02	1.799	7 ADH4, ADH6, AKR1D1, DHRS2, HPGD, HSD11B1, RDH16	74	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016712	4.886e-02	0.2917	3 CYP1A2, CYP2C8, CYP3A43	12	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0070330	4.886e-02	0.2917	3 CYP1A2, CYP2C8, CYP3A43	12	aromatase activity

Id	Pvalue	ExpCount	Count	Size	Term
04610	2.039e-13	1.668	19 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFH, CPB2, F10, F11, F2, F7, F9, FGB, FGG, KLKB1, SERPINC1, SERPIND1	50	Complement and coagulation cascades
00830	4.683e-04	0.8342	7 ADH4, ADH6, ALDH1A1, CYP1A2, CYP2C8, CYP3A43, RDH16	25	Retinol metabolism
00982	7.501e-04	0.9009	7 ADH4, ADH6, CYP1A2, CYP2C8, CYP3A43, FMO3, FMO5	27	Drug metabolism - cytochrome P450
01100	1.738e-03	26.86	46 ACOX1, ACSL5, ADH4, ADH6, ADK, AGXT, AKR1D1, ALAS1, ALDH1A1, ALG5, ALG8, AMDHD1, ARG1, BAAT, CTPS, CYP1A2, CYP2C8, CYP3A43, ENPP1, GCH1, GNE, GPAM, HAL, HAO1, HMGCS2, HSD11B1, LIPC, MAT1A, MUT, NAT1, NAT2, NNMT, OTC, POLE2, POLR1A, PON1, PON3, PRDX6, RDH16, SCP2, SDS, TAT, TDO2, TGDS, UGP2, UROC1	805	Metabolic pathways
00232	4.081e-03	0.1335	3 CYP1A2, NAT1, NAT2	4	Caffeine metabolism
00980	4.598e-03	0.8676	6 ADH4, ADH6, CYP1A2, CYP2C8, CYP3A43, EPHX1	26	Metabolism of xenobiotics by cytochrome P450
00120	5.737e-03	0.3337	4 AKR1D1, BAAT, CYP39A1, SCP2	10	Primary bile acid biosynthesis
05020	1.990e-02	0.8008	5 C5, C8A, C8B, C8G, C9	24	Prion diseases
04950	2.411e-02	0.5005	4 FOXA3, NR5A2, PDX1, SLC2A2	15	Maturity onset diabetes of the young

No enriched terms

No enriched terms

Entrez genes

ABCG5ATP-binding cassette, sub-family G (WHITE), member 5 (ENSG00000138075), score: 0.58 ACOT12acyl-CoA thioesterase 12 (ENSG00000172497), score: 0.61 ACOX1acyl-CoA oxidase 1, palmitoyl (ENSG00000161533), score: 0.51 ACSL5acyl-CoA synthetase long-chain family member 5 (ENSG00000197142), score: 0.51 ADH4alcohol dehydrogenase 4 (class II), pi polypeptide (ENSG00000198099), score: 0.58 ADH6alcohol dehydrogenase 6 (class V) (ENSG00000172955), score: 0.52 ADKadenosine kinase (ENSG00000156110), score: 0.55 AFMafamin (ENSG00000079557), score: 0.6 AGTR1angiotensin II receptor, type 1 (ENSG00000144891), score: 0.54 AGXTalanine-glyoxylate aminotransferase (ENSG00000172482), score: 0.54 AIG1androgen-induced 1 (ENSG00000146416), score: 0.51 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.57 ALAS1aminolevulinate, delta-, synthase 1 (ENSG00000023330), score: 0.51 ALBalbumin (ENSG00000163631), score: 0.53 ALDH1A1aldehyde dehydrogenase 1 family, member A1 (ENSG00000165092), score: 0.5 ALG5asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae) (ENSG00000120697), score: 0.53 ALG8asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae) (ENSG00000159063), score: 0.52 AMBPalpha-1-microglobulin/bikunin precursor (ENSG00000106927), score: 0.54 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.55 ANKRD11ankyrin repeat domain 11 (ENSG00000167522), score: -0.53 ANKRD27ankyrin repeat domain 27 (VPS9 domain) (ENSG00000105186), score: -0.52 APCSamyloid P component, serum (ENSG00000132703), score: 0.58 APOBapolipoprotein B (including Ag(x) antigen) (ENSG00000084674), score: 0.59 APOC1apolipoprotein C-I (ENSG00000130208), score: 0.57 APOC3apolipoprotein C-III (ENSG00000110245), score: 0.57 AQP9aquaporin 9 (ENSG00000103569), score: 0.59 ARG1arginase, liver (ENSG00000118520), score: 0.65 ARHGEF26Rho guanine nucleotide exchange factor (GEF) 26 (ENSG00000114790), score: 0.51 ARRDC3arrestin domain containing 3 (ENSG00000113369), score: 0.53 ART4ADP-ribosyltransferase 4 (Dombrock blood group) (ENSG00000111339), score: 0.53 ASB1ankyrin repeat and SOCS box-containing 1 (ENSG00000065802), score: -0.51 ASPGasparaginase homolog (S. cerevisiae) (ENSG00000166183), score: 0.5 AUP1ancient ubiquitous protein 1 (ENSG00000115307), score: 0.55 BAATbile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) (ENSG00000136881), score: 0.57 BCHEbutyrylcholinesterase (ENSG00000114200), score: 0.61 C10orf11chromosome 10 open reading frame 11 (ENSG00000148655), score: 0.51 C10orf32chromosome 10 open reading frame 32 (ENSG00000166275), score: 0.51 C12orf35chromosome 12 open reading frame 35 (ENSG00000174718), score: 0.52 C14orf21chromosome 14 open reading frame 21 (ENSG00000196943), score: 0.55 C15orf59chromosome 15 open reading frame 59 (ENSG00000205363), score: -0.53 C20orf108chromosome 20 open reading frame 108 (ENSG00000124098), score: 0.51 C4BPAcomplement component 4 binding protein, alpha (ENSG00000123838), score: 0.56 C4BPBcomplement component 4 binding protein, beta (ENSG00000123843), score: 0.59 C4orf34chromosome 4 open reading frame 34 (ENSG00000163683), score: 0.62 C5complement component 5 (ENSG00000106804), score: 0.56 C5orf33chromosome 5 open reading frame 33 (ENSG00000152620), score: 0.63 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.56 C8Bcomplement component 8, beta polypeptide (ENSG00000021852), score: 0.56 C8Gcomplement component 8, gamma polypeptide (ENSG00000176919), score: 0.51 C8orf40chromosome 8 open reading frame 40 (ENSG00000176209), score: 0.6 C9complement component 9 (ENSG00000113600), score: 0.56 CCDC152coiled-coil domain containing 152 (ENSG00000198865), score: 0.5 CCDC73coiled-coil domain containing 73 (ENSG00000186714), score: 0.57 CCR2chemokine (C-C motif) receptor 2 (ENSG00000121807), score: 0.57 CD200R1CD200 receptor 1 (ENSG00000163606), score: 0.63 CD247CD247 molecule (ENSG00000198821), score: 0.54 CD3DCD3d molecule, delta (CD3-TCR complex) (ENSG00000167286), score: 0.52 CD4CD4 molecule (ENSG00000010610), score: 0.56 CD69CD69 molecule (ENSG00000110848), score: 0.51 CDK16cyclin-dependent kinase 16 (ENSG00000102225), score: -0.51 CFHcomplement factor H (ENSG00000000971), score: 0.51 CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (ENSG00000001626), score: 0.5 CIDEBcell death-inducing DFFA-like effector b (ENSG00000136305), score: 0.51 CLEC1BC-type lectin domain family 1, member B (ENSG00000165682), score: 0.79 CLEC4GC-type lectin domain family 4, member G (ENSG00000182566), score: 0.5 CNPY3canopy 3 homolog (zebrafish) (ENSG00000137161), score: 0.61 COLEC10collectin sub-family member 10 (C-type lectin) (ENSG00000184374), score: 0.53 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.6 CREB3L3cAMP responsive element binding protein 3-like 3 (ENSG00000060566), score: 0.53 CTPSCTP synthase (ENSG00000171793), score: 0.5 CXCL2chemokine (C-X-C motif) ligand 2 (ENSG00000081041), score: 0.54 CXCR6chemokine (C-X-C motif) receptor 6 (ENSG00000172215), score: 0.53 CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 2 (ENSG00000140505), score: 0.63 CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 8 (ENSG00000138115), score: 0.6 CYP39A1cytochrome P450, family 39, subfamily A, polypeptide 1 (ENSG00000146233), score: 0.53 CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 43 (ENSG00000021461), score: 0.7 DAPP1dual adaptor of phosphotyrosine and 3-phosphoinositides (ENSG00000070190), score: 0.56 DCPSdecapping enzyme, scavenger (ENSG00000110063), score: 0.57 DEPDC7DEP domain containing 7 (ENSG00000121690), score: 0.55 DHRS2dehydrogenase/reductase (SDR family) member 2 (ENSG00000100867), score: 0.7 DHTKD1dehydrogenase E1 and transketolase domain containing 1 (ENSG00000181192), score: 0.52 DIP2CDIP2 disco-interacting protein 2 homolog C (Drosophila) (ENSG00000151240), score: -0.54 DLG5discs, large homolog 5 (Drosophila) (ENSG00000151208), score: -0.63 DMWDdystrophia myotonica, WD repeat containing (ENSG00000185800), score: -0.51 DNASE1L3deoxyribonuclease I-like 3 (ENSG00000163687), score: 0.54 DSG1desmoglein 1 (ENSG00000134760), score: 0.69 EBNA1BP2EBNA1 binding protein 2 (ENSG00000117395), score: 0.52 EI24etoposide induced 2.4 mRNA (ENSG00000149547), score: 0.57 ELP2elongation protein 2 homolog (S. cerevisiae) (ENSG00000134759), score: 0.63 ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENSG00000197594), score: 0.53 EPHX1epoxide hydrolase 1, microsomal (xenobiotic) (ENSG00000143819), score: 0.51 ERLIN1ER lipid raft associated 1 (ENSG00000107566), score: 0.54 ERRFI1ERBB receptor feedback inhibitor 1 (ENSG00000116285), score: 0.62 F10coagulation factor X (ENSG00000126218), score: 0.5 F11coagulation factor XI (ENSG00000088926), score: 0.56 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.54 F7coagulation factor VII (serum prothrombin conversion accelerator) (ENSG00000057593), score: 0.57 F9coagulation factor IX (ENSG00000101981), score: 0.59 FAM82A1family with sequence similarity 82, member A1 (ENSG00000115841), score: 0.53 FAM96Afamily with sequence similarity 96, member A (ENSG00000166797), score: 0.56 FASLGFas ligand (TNF superfamily, member 6) (ENSG00000117560), score: 0.61 FAT1FAT tumor suppressor homolog 1 (Drosophila) (ENSG00000083857), score: -0.51 FBXL4F-box and leucine-rich repeat protein 4 (ENSG00000112234), score: 0.52 FCRLAFc receptor-like A (ENSG00000132185), score: 0.55 FETUBfetuin B (ENSG00000090512), score: 0.56 FGBfibrinogen beta chain (ENSG00000171564), score: 0.53 FGGfibrinogen gamma chain (ENSG00000171557), score: 0.54 FMO3flavin containing monooxygenase 3 (ENSG00000007933), score: 0.58 FMO5flavin containing monooxygenase 5 (ENSG00000131781), score: 0.57 FOXA3forkhead box A3 (ENSG00000170608), score: 0.59 GABRPgamma-aminobutyric acid (GABA) A receptor, pi (ENSG00000094755), score: 0.63 GCgroup-specific component (vitamin D binding protein) (ENSG00000145321), score: 0.53 GCH1GTP cyclohydrolase 1 (ENSG00000131979), score: 0.51 GCKRglucokinase (hexokinase 4) regulator (ENSG00000084734), score: 0.5 GNA11guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (ENSG00000088256), score: -0.5 GNA12guanine nucleotide binding protein (G protein) alpha 12 (ENSG00000146535), score: -0.58 GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (ENSG00000159921), score: 0.59 GNMTglycine N-methyltransferase (ENSG00000124713), score: 0.63 GNPNAT1glucosamine-phosphate N-acetyltransferase 1 (ENSG00000100522), score: 0.62 GPAMglycerol-3-phosphate acyltransferase, mitochondrial (ENSG00000119927), score: 0.51 GPR128G protein-coupled receptor 128 (ENSG00000144820), score: 0.95 GRB14growth factor receptor-bound protein 14 (ENSG00000115290), score: 0.51 GTF3Ageneral transcription factor IIIA (ENSG00000122034), score: 0.5 GYS2glycogen synthase 2 (liver) (ENSG00000111713), score: 0.61 GZMAgranzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) (ENSG00000145649), score: 0.52 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.63 HAMPhepcidin antimicrobial peptide (ENSG00000105697), score: 0.54 HAO1hydroxyacid oxidase (glycolate oxidase) 1 (ENSG00000101323), score: 0.63 HINT1histidine triad nucleotide binding protein 1 (ENSG00000169567), score: 0.52 HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (ENSG00000134240), score: 0.53 HPGDhydroxyprostaglandin dehydrogenase 15-(NAD) (ENSG00000164120), score: 0.52 HPS3Hermansky-Pudlak syndrome 3 (ENSG00000163755), score: 0.6 HPXhemopexin (ENSG00000110169), score: 0.54 HRGhistidine-rich glycoprotein (ENSG00000113905), score: 0.52 HSD11B1hydroxysteroid (11-beta) dehydrogenase 1 (ENSG00000117594), score: 0.53 HSD17B13hydroxysteroid (17-beta) dehydrogenase 13 (ENSG00000170509), score: 0.51 IFT172intraflagellar transport 172 homolog (Chlamydomonas) (ENSG00000138002), score: -0.54 IGF1Rinsulin-like growth factor 1 receptor (ENSG00000140443), score: -0.6 IGFBP1insulin-like growth factor binding protein 1 (ENSG00000146678), score: 0.55 IL18R1interleukin 18 receptor 1 (ENSG00000115604), score: 0.51 IL18RAPinterleukin 18 receptor accessory protein (ENSG00000115607), score: 0.63 IL1RNinterleukin 1 receptor antagonist (ENSG00000136689), score: 0.56 IL2RBinterleukin 2 receptor, beta (ENSG00000100385), score: 0.52 IL6Rinterleukin 6 receptor (ENSG00000160712), score: 0.54 INHBCinhibin, beta C (ENSG00000175189), score: 0.59 INSIG1insulin induced gene 1 (ENSG00000186480), score: 0.54 ITIH1inter-alpha (globulin) inhibitor H1 (ENSG00000055957), score: 0.54 ITIH3inter-alpha (globulin) inhibitor H3 (ENSG00000162267), score: 0.52 ITKIL2-inducible T-cell kinase (ENSG00000113263), score: 0.57 JAGN1jagunal homolog 1 (Drosophila) (ENSG00000171135), score: 0.54 JTBjumping translocation breakpoint (ENSG00000143543), score: 0.51 KIAA0922KIAA0922 (ENSG00000121210), score: 0.54 KIF22kinesin family member 22 (ENSG00000079616), score: 0.5 KIR3DL3killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 (ENSG00000189013), score: 0.68 KLHL18kelch-like 18 (Drosophila) (ENSG00000114648), score: -0.52 KLKB1kallikrein B, plasma (Fletcher factor) 1 (ENSG00000164344), score: 0.59 KLRD1killer cell lectin-like receptor subfamily D, member 1 (ENSG00000134539), score: 0.63 KLRF1killer cell lectin-like receptor subfamily F, member 1 (ENSG00000150045), score: 0.73 LECT2leukocyte cell-derived chemotaxin 2 (ENSG00000145826), score: 0.63 LEPRleptin receptor (ENSG00000116678), score: 0.76 LIPClipase, hepatic (ENSG00000166035), score: 0.57 LOC100292021similar to thioredoxin peroxidase (ENSG00000123131), score: 0.51 LOC55908hepatocellular carcinoma-associated gene TD26 (ENSG00000130173), score: 0.54 LRG1leucine-rich alpha-2-glycoprotein 1 (ENSG00000171236), score: 0.54 MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) (ENSG00000197063), score: -0.56 MAT1Amethionine adenosyltransferase I, alpha (ENSG00000151224), score: 0.57 MED15mediator complex subunit 15 (ENSG00000099917), score: -0.51 MIER2mesoderm induction early response 1, family member 2 (ENSG00000105556), score: -0.52 MKL1megakaryoblastic leukemia (translocation) 1 (ENSG00000196588), score: -0.56 MLL2myeloid/lymphoid or mixed-lineage leukemia 2 (ENSG00000167548), score: -0.51 MOGAT1monoacylglycerol O-acyltransferase 1 (ENSG00000124003), score: 0.7 MOGAT3monoacylglycerol O-acyltransferase 3 (ENSG00000106384), score: 0.59 MPDU1mannose-P-dolichol utilization defect 1 (ENSG00000129255), score: 0.55 MRPL19mitochondrial ribosomal protein L19 (ENSG00000115364), score: 0.5 MS4A1membrane-spanning 4-domains, subfamily A, member 1 (ENSG00000156738), score: 0.69 MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A (ENSG00000110077), score: 0.56 MSI2musashi homolog 2 (Drosophila) (ENSG00000153944), score: -0.52 MTTPmicrosomal triglyceride transfer protein (ENSG00000138823), score: 0.51 MUTmethylmalonyl CoA mutase (ENSG00000146085), score: 0.55 MYO1Bmyosin IB (ENSG00000128641), score: 0.51 NAT1N-acetyltransferase 1 (arylamine N-acetyltransferase) (ENSG00000171428), score: 0.61 NAT2N-acetyltransferase 2 (arylamine N-acetyltransferase) (ENSG00000156006), score: 0.64 NCK2NCK adaptor protein 2 (ENSG00000071051), score: -0.52 NCR1natural cytotoxicity triggering receptor 1 (ENSG00000189430), score: 0.66 NEDD4neural precursor cell expressed, developmentally down-regulated 4 (ENSG00000069869), score: 0.56 NNMTnicotinamide N-methyltransferase (ENSG00000166741), score: 0.5 NOL11nucleolar protein 11 (ENSG00000130935), score: 0.62 NPC1L1NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (ENSG00000015520), score: 0.59 NR1H4nuclear receptor subfamily 1, group H, member 4 (ENSG00000012504), score: 0.5 NR1I2nuclear receptor subfamily 1, group I, member 2 (ENSG00000144852), score: 0.55 NR1I3nuclear receptor subfamily 1, group I, member 3 (ENSG00000143257), score: 0.55 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.59 NRBF2nuclear receptor binding factor 2 (ENSG00000148572), score: 0.57 NSUN6NOP2/Sun domain family, member 6 (ENSG00000241058), score: 0.51 NUDT5nudix (nucleoside diphosphate linked moiety X)-type motif 5 (ENSG00000165609), score: 0.56 OIT3oncoprotein induced transcript 3 (ENSG00000138315), score: 0.51 ORAI3ORAI calcium release-activated calcium modulator 3 (ENSG00000175938), score: 0.52 ORM1orosomucoid 1 (ENSG00000229314), score: 0.53 OTCornithine carbamoyltransferase (ENSG00000036473), score: 0.61 PACS1phosphofurin acidic cluster sorting protein 1 (ENSG00000175115), score: -0.52 PDX1pancreatic and duodenal homeobox 1 (ENSG00000139515), score: 0.51 PEX11Aperoxisomal biogenesis factor 11 alpha (ENSG00000166821), score: 0.58 PGLYRP2peptidoglycan recognition protein 2 (ENSG00000161031), score: 0.57 PLXNA1plexin A1 (ENSG00000114554), score: -0.54 POLE2polymerase (DNA directed), epsilon 2 (p59 subunit) (ENSG00000100479), score: 0.56 POLR1Apolymerase (RNA) I polypeptide A, 194kDa (ENSG00000068654), score: -0.52 PON1paraoxonase 1 (ENSG00000005421), score: 0.61 PON3paraoxonase 3 (ENSG00000105852), score: 0.57 PPARDperoxisome proliferator-activated receptor delta (ENSG00000112033), score: -0.53 PRDX6peroxiredoxin 6 (ENSG00000117592), score: 0.53 PRF1perforin 1 (pore forming protein) (ENSG00000180644), score: 0.52 PRG4proteoglycan 4 (ENSG00000116690), score: 0.52 PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (ENSG00000134242), score: 0.5 PYGLphosphorylase, glycogen, liver (ENSG00000100504), score: 0.5 PYHIN1pyrin and HIN domain family, member 1 (ENSG00000163564), score: 0.51 RAD23BRAD23 homolog B (S. cerevisiae) (ENSG00000119318), score: 0.5 RCL1RNA terminal phosphate cyclase-like 1 (ENSG00000120158), score: 0.53 RDH16retinol dehydrogenase 16 (all-trans) (ENSG00000139547), score: 0.55 REREarginine-glutamic acid dipeptide (RE) repeats (ENSG00000142599), score: -0.51 RHOFras homolog gene family, member F (in filopodia) (ENSG00000139725), score: -0.51 RIPPLY1ripply1 homolog (zebrafish) (ENSG00000147223), score: 0.54 RMND1required for meiotic nuclear division 1 homolog (S. cerevisiae) (ENSG00000155906), score: 0.59 RNF185ring finger protein 185 (ENSG00000138942), score: 0.52 RTP3receptor (chemosensory) transporter protein 3 (ENSG00000163825), score: 0.51 RTP4receptor (chemosensory) transporter protein 4 (ENSG00000136514), score: 0.5 RWDD3RWD domain containing 3 (ENSG00000122481), score: 0.54 SAMD3sterile alpha motif domain containing 3 (ENSG00000164483), score: 0.63 SAR1BSAR1 homolog B (S. cerevisiae) (ENSG00000152700), score: 0.54 SCN9Asodium channel, voltage-gated, type IX, alpha subunit (ENSG00000169432), score: 0.64 SCP2sterol carrier protein 2 (ENSG00000116171), score: 0.51 SDSserine dehydratase (ENSG00000135094), score: 0.6 SEC14L3SEC14-like 3 (S. cerevisiae) (ENSG00000100012), score: 0.66 SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (ENSG00000140093), score: 0.6 SERPINA11serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 (ENSG00000186910), score: 0.58 SERPINA4serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 (ENSG00000100665), score: 0.59 SERPINA7serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 (ENSG00000123561), score: 0.62 SERPINA9serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 (ENSG00000170054), score: 0.56 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.56 SERPIND1serpin peptidase inhibitor, clade D (heparin cofactor), member 1 (ENSG00000099937), score: 0.54 SF3B14splicing factor 3B, 14 kDa subunit (ENSG00000115128), score: 0.54 SIAH2seven in absentia homolog 2 (Drosophila) (ENSG00000181788), score: 0.6 SIGMAR1sigma non-opioid intracellular receptor 1 (ENSG00000147955), score: 0.54 SIN3BSIN3 homolog B, transcription regulator (yeast) (ENSG00000127511), score: -0.52 SKP2S-phase kinase-associated protein 2 (p45) (ENSG00000145604), score: 0.64 SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (ENSG00000100652), score: 0.59 SLC13A5solute carrier family 13 (sodium-dependent citrate transporter), member 5 (ENSG00000141485), score: 0.57 SLC16A2solute carrier family 16, member 2 (monocarboxylic acid transporter 8) (ENSG00000147100), score: 0.51 SLC17A2solute carrier family 17 (sodium phosphate), member 2 (ENSG00000112337), score: 0.55 SLC17A9solute carrier family 17, member 9 (ENSG00000101194), score: 0.51 SLC22A1solute carrier family 22 (organic cation transporter), member 1 (ENSG00000175003), score: 0.55 SLC22A3solute carrier family 22 (extraneuronal monoamine transporter), member 3 (ENSG00000146477), score: 0.59 SLC25A13solute carrier family 25, member 13 (citrin) (ENSG00000004864), score: 0.5 SLC25A15solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 (ENSG00000102743), score: 0.64 SLC25A38solute carrier family 25, member 38 (ENSG00000144659), score: 0.62 SLC25A47solute carrier family 25, member 47 (ENSG00000140107), score: 0.57 SLC2A2solute carrier family 2 (facilitated glucose transporter), member 2 (ENSG00000163581), score: 0.55 SLC35D1solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 (ENSG00000116704), score: 0.59 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.6 SLC39A11solute carrier family 39 (metal ion transporter), member 11 (ENSG00000133195), score: 0.53 SLC43A1solute carrier family 43, member 1 (ENSG00000149150), score: 0.58 SLC45A2solute carrier family 45, member 2 (ENSG00000164175), score: 0.51 SLC46A3solute carrier family 46, member 3 (ENSG00000139508), score: 0.51 SLCO1B1solute carrier organic anion transporter family, member 1B1 (ENSG00000134538), score: 0.56 SLCO1B3solute carrier organic anion transporter family, member 1B3 (ENSG00000111700), score: 0.68 SLCO2B1solute carrier organic anion transporter family, member 2B1 (ENSG00000137491), score: 0.51 SLPIsecretory leukocyte peptidase inhibitor (ENSG00000124107), score: 0.52 SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (ENSG00000127616), score: -0.54 SORT1sortilin 1 (ENSG00000134243), score: -0.6 SPG20spastic paraplegia 20 (Troyer syndrome) (ENSG00000133104), score: -0.65 SPP2secreted phosphoprotein 2, 24kDa (ENSG00000072080), score: 0.65 SPRYD4SPRY domain containing 4 (ENSG00000176422), score: 0.51 SRCAPSnf2-related CREBBP activator protein (ENSG00000080603), score: -0.51 SRD5A2steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (ENSG00000049319), score: 0.7 SULT1B1sulfotransferase family, cytosolic, 1B, member 1 (ENSG00000173597), score: 0.53 SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (ENSG00000105398), score: 0.62 TANKTRAF family member-associated NFKB activator (ENSG00000136560), score: 0.55 TATtyrosine aminotransferase (ENSG00000198650), score: 0.62 TBX21T-box 21 (ENSG00000073861), score: 0.59 TCN1transcobalamin I (vitamin B12 binding protein, R binder family) (ENSG00000134827), score: 0.61 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.63 TFF2trefoil factor 2 (ENSG00000160181), score: 0.63 TGDSTDP-glucose 4,6-dehydratase (ENSG00000088451), score: 0.67 TIGD2tigger transposable element derived 2 (ENSG00000180346), score: 0.65 TM4SF4transmembrane 4 L six family member 4 (ENSG00000169903), score: 0.57 TMCO3transmembrane and coiled-coil domains 3 (ENSG00000150403), score: -0.54 TMED6transmembrane emp24 protein transport domain containing 6 (ENSG00000157315), score: 0.6 TMEM135transmembrane protein 135 (ENSG00000166575), score: 0.52 TMEM195transmembrane protein 195 (ENSG00000187546), score: 0.6 TMEM220transmembrane protein 220 (ENSG00000187824), score: 0.53 TMEM231transmembrane protein 231 (ENSG00000205084), score: -0.53 TMEM45Atransmembrane protein 45A (ENSG00000181458), score: 0.55 TOM1L2target of myb1-like 2 (chicken) (ENSG00000175662), score: -0.52 TP53BP1tumor protein p53 binding protein 1 (ENSG00000067369), score: -0.51 TRIB1tribbles homolog 1 (Drosophila) (ENSG00000173334), score: 0.61 TRPM8transient receptor potential cation channel, subfamily M, member 8 (ENSG00000144481), score: 0.63 TSPAN3tetraspanin 3 (ENSG00000140391), score: -0.54 TTC39Ctetratricopeptide repeat domain 39C (ENSG00000168234), score: 0.58 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.54 TTRtransthyretin (ENSG00000118271), score: 0.5 TXNL1thioredoxin-like 1 (ENSG00000091164), score: 0.51 UBAP2Lubiquitin associated protein 2-like (ENSG00000143569), score: -0.51 UGP2UDP-glucose pyrophosphorylase 2 (ENSG00000169764), score: 0.58 UNC93Aunc-93 homolog A (C. elegans) (ENSG00000112494), score: 0.56 UNGuracil-DNA glycosylase (ENSG00000076248), score: 0.56 UROC1urocanase domain containing 1 (ENSG00000159650), score: 0.53 XBP1X-box binding protein 1 (ENSG00000100219), score: 0.5 ZCCHC6zinc finger, CCHC domain containing 6 (ENSG00000083223), score: 0.55 ZGPATzinc finger, CCCH-type with G patch domain (ENSG00000197114), score: 0.55

Non-Entrez genes

ENSG00000110245Unknown, score: 1 ENSG00000143819Unknown, score: 0.52

Id	species	tissue	sex	individual
ppa_lv_m_ca1	ppa	lv	m	_
hsa_lv_m1_ca1	hsa	lv	m	1
ppa_lv_f_ca1	ppa	lv	f	_