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skeletal system development

The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

regionalization

The pattern specification process by which an axis or axes is subdivided in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

anion transport

The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

amino acid transport

The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

embryo development

The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.

pattern specification process

Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

response to nutrient

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

embryo development ending in birth or egg hatching

The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.

anterior/posterior pattern formation

The regionalization process by which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to extracellular stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

organic cation transport

The directed movement of organic cations into, out of, within or between cells by means of some external agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.

organic anion transport

The directed movement of organic anions into, out of, within or between cells by means of some external agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.

amine transport

The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of, within or between cells by means of some external agent such as a transporter or pore.

organic acid transport

The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells by means of some external agent such as a transporter or pore.

vitamin transport

The directed movement of vitamins into, out of, within or between cells by means of some external agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules.

calcium-independent cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction.

biological adhesion

The attachment of a cell or organism to a substrate or other organism.

signaling pathway

The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.

intracellular signaling pathway

The series of molecular events whereby information is sent from one location to another within a cell.

signaling

The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

intracellular receptor mediated signaling pathway

Any series of molecular signals initiated by a ligand binding to an receptor located within a cell.

epithelial cell differentiation

The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

response to nutrient levels

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.

cellular response to extracellular stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

cellular response to nutrient levels

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.

cellular response to nutrient

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

response to vitamin

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.

response to vitamin D

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

homeostatic process

Any biological process involved in the maintenance of an internal steady-state.

chordate embryonic development

The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.

ion homeostasis

Any process involved in the maintenance of an internal steady-state of ions within an organism or cell.

carboxylic acid transport

The directed movement of carboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ morphogenesis

Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ development

Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic morphogenesis

The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.

embryonic skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form.

skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized. Morphogenesis pertains to the creation of form.

embryonic skeletal system development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

chemical homeostasis

Any biological process involved in the maintenance of an internal steady-state of a chemical.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

cation homeostasis

Any process involved in the maintenance of an internal steady-state of cations within an organism or cell.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

epithelium development

The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

vitamin D receptor signaling pathway

The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands.

cellular response to chemical stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

cellular response to vitamin

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.

cellular response to vitamin D

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.

cellular response to external stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

all

NA

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular response to extracellular stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

embryo development

The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.

pattern specification process

Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

embryonic morphogenesis

The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

cellular response to chemical stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ morphogenesis

Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ morphogenesis

Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

embryonic organ development

Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

cellular response to extracellular stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

cellular response to extracellular stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

cellular response to nutrient

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

cellular response to nutrient

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized. Morphogenesis pertains to the creation of form.

embryonic skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form.

embryonic skeletal system development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.

epithelial cell differentiation

The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

response to nutrient

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

cellular response to nutrient levels

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.

cellular response to vitamin

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.

amino acid transport

The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore.

embryonic skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form.

cellular response to vitamin D

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

vitamin D receptor signaling pathway

The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

cell fraction

A generic term for parts of cells prepared by disruptive biochemical techniques.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

membrane fraction

That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes.

insoluble fraction

That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

brush border

Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.

cell-cell junction

A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals.

tight junction

An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.

basolateral plasma membrane

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

apicolateral plasma membrane

The apical end of the lateral plasma membrane of epithelial cells.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

cell junction

A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.

organelle membrane

The lipid bilayer surrounding an organelle.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

apical junction complex

A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in invertebrates is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

occluding junction

A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

apical junction complex

A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in invertebrates is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.

tight junction

An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

nucleic acid binding

Interacting selectively and non-covalently with any nucleic acid.

DNA binding

Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).

sequence-specific DNA binding transcription factor activity

Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

metal ion transmembrane transporter activity

Catalysis of the transfer of metal ions from one side of a membrane to the other.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

amine transmembrane transporter activity

Catalysis of the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.

amino acid transmembrane transporter activity

Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

organic acid transmembrane transporter activity

Catalysis of the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other.

secondary active transmembrane transporter activity

Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.

inorganic anion exchanger activity

NA

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

anion transmembrane transporter activity

Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

monovalent inorganic cation transmembrane transporter activity

Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

sodium ion transmembrane transporter activity

Catalysis of the transfer of sodium ions (Na+) from one side of a membrane to the other.

organic cation transmembrane transporter activity

Catalysis of the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.

inorganic anion transmembrane transporter activity

Catalysis of the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.

neutral amino acid transmembrane transporter activity

Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7.

drug transmembrane transporter activity

Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.

symporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

solute:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).

anion:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in).

antiporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

solute:solute antiporter activity

Catalysis of the reaction: solute A(out) + solute B(in) = solute A(in) + solute B(out).

anion:anion antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).

anion exchanger activity

NA

active transmembrane transporter activity

Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.

inorganic cation transmembrane transporter activity

Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

sequence-specific DNA binding

Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

carboxylic acid transmembrane transporter activity

Catalysis of the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

amine transmembrane transporter activity

Catalysis of the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.

amino acid transmembrane transporter activity

Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.

solute:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).

anion:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in).

anion:anion antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).

sodium ion transmembrane transporter activity

Catalysis of the transfer of sodium ions (Na+) from one side of a membrane to the other.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0006811	9.170e-12	23.19	65 ABCC4, ANO7, AQP2, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, CLCN5, CLCNKA, CLDN16, CSN2, CYP27B1, EGF, FXYD2, KCNJ1, KCNJ16, KCNQ1, KCNS3, PLCG2, PRSS8, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC26A7, SLC30A2, SLC34A1, SLC34A3, SLC38A8, SLC39A5, SLC3A2, SLC4A1, SLC5A10, SLC5A12, SLC5A8, SLC9A3, SLC9A4, SLCO4C1, TCN2, TPCN1, TRPM6, TRPV4, VDR, WNK4	663	ion transport
GO:0007588	6.612e-11	1.644	17 AQP2, AQP6, ATP6V0A4, ATP6V1B1, BTC, CLCN5, CLCNKA, CLDN16, DAB2, KCNJ1, NPHS2, NPR3, OXT, SCNN1A, SCNN1B, SCNN1G, SCTR	47	excretion
GO:0006812	7.680e-11	16.72	52 AQP2, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, CSN2, CYP27B1, EGF, FXYD2, KCNJ1, KCNJ16, KCNQ1, KCNS3, PLCG2, PRSS8, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC23A1, SLC30A2, SLC34A1, SLC34A3, SLC38A8, SLC39A5, SLC3A2, SLC5A10, SLC5A12, SLC5A8, SLC9A3, SLC9A4, TCN2, TPCN1, TRPM6, TRPV4, VDR	478	cation transport
GO:0006814	5.997e-10	4.093	24 ATP1A1, FXYD2, PRSS8, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC22A4, SLC22A5, SLC23A1, SLC34A1, SLC34A3, SLC38A8, SLC5A10, SLC5A12, SLC5A8, SLC9A3, SLC9A4	117	sodium ion transport
GO:0055085	3.850e-09	20.54	55 ABCC4, AQP2, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, CLCN5, CLCNKA, EGF, KCNQ1, KCNS3, PLCG2, RHBG, RHCG, SFXN2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC23A3, SLC25A45, SLC26A7, SLC30A2, SLC37A4, SLC39A5, SLC5A10, SLC5A12, SLC5A8, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, SPNS3, TPCN1, TRPM6, TRPV4	587	transmembrane transport
GO:0015672	1.506e-08	8.886	33 ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, FXYD2, KCNJ1, KCNJ16, KCNQ1, KCNS3, PRSS8, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC22A4, SLC22A5, SLC23A1, SLC34A1, SLC34A3, SLC38A8, SLC5A10, SLC5A12, SLC5A8, SLC9A3, SLC9A4	254	monovalent inorganic cation transport
GO:0009952	1.764e-08	4.058	22 HNF1B, HOXA10, HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC5, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, RIPPLY1, TDGF1, ZBTB16	116	anterior/posterior pattern formation
GO:0030001	2.038e-08	14.34	43 AQP2, ATP12A, ATP1A1, CSN2, CYP27B1, EGF, FXYD2, KCNJ1, KCNJ16, KCNQ1, KCNS3, PLCG2, PRSS8, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC22A4, SLC22A5, SLC23A1, SLC30A2, SLC34A1, SLC34A3, SLC38A8, SLC39A5, SLC3A2, SLC5A10, SLC5A12, SLC5A8, SLC9A3, SLC9A4, TCN2, TPCN1, TRPM6, TRPV4, VDR	410	metal ion transport
GO:0001501	6.306e-07	7.801	28 BMP3, COL19A1, EVC, HOXA10, HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC5, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, MATN3, NPR3, PTH1R, TFAP2A, TULP3, VDR, ZBTB16	223	skeletal system development
GO:0048704	9.624e-07	1.679	13 HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXD10, HOXD3, HOXD4, HOXD9, TFAP2A, TULP3	48	embryonic skeletal system morphogenesis
GO:0006810	1.232e-06	77.88	124 ABCA4, ABCC4, ADIPOQ, AFP, ANO7, AP1M2, AP3S1, AQP2, AQP6, ARSB, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BDKRB2, BTC, CD3G, CLCN5, CLCNKA, CLDN16, CSN2, CUBN, CYP27B1, DAB2, EGF, FAM3D, FKBP15, FOLR1, FXYD2, GAL, GOSR2, HNF1B, KCNJ1, KCNJ16, KCNQ1, KCNS3, NPHS2, NPR3, NRG1, OXT, PLCG2, PNLIP, PPY, PRLR, PRSS8, RAB19, RAB25, RAB34, RAB38, RAB7L1, RHBG, RHCG, SCAMP2, SCIN, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC23A3, SLC25A45, SLC26A7, SLC30A2, SLC34A1, SLC34A3, SLC35F2, SLC37A4, SLC38A8, SLC39A5, SLC3A2, SLC4A1, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, SLCO4C1, SPNS3, STRA6, TCN2, TMED4, TNFSF15, TPCN1, TRAF3IP2, TRPM6, TRPV4, UCN3, VAV3, VDR, WNK4	2226	transport
GO:0051234	1.277e-06	78.78	125 ABCA4, ABCC4, ADIPOQ, AFP, ANO7, AP1M2, AP3S1, AQP2, AQP6, ARSB, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BDKRB2, BTC, CD3G, CLCN5, CLCNKA, CLDN16, CSN2, CUBN, CYP27B1, DAB2, DPP4, EGF, FAM3D, FKBP15, FOLR1, FXYD2, GAL, GOSR2, HNF1B, KCNJ1, KCNJ16, KCNQ1, KCNS3, NPHS2, NPR3, NRG1, OXT, PLCG2, PNLIP, PPY, PRLR, PRSS8, RAB19, RAB25, RAB34, RAB38, RAB7L1, RHBG, RHCG, SCAMP2, SCIN, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC23A3, SLC25A45, SLC26A7, SLC30A2, SLC34A1, SLC34A3, SLC35F2, SLC37A4, SLC38A8, SLC39A5, SLC3A2, SLC4A1, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, SLCO4C1, SPNS3, STRA6, TCN2, TMED4, TNFSF15, TPCN1, TRAF3IP2, TRPM6, TRPV4, UCN3, VAV3, VDR, WNK4	2252	establishment of localization
GO:0048706	1.613e-06	2.414	15 HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC5, HOXC6, HOXD10, HOXD3, HOXD4, HOXD9, TFAP2A, TULP3	69	embryonic skeletal system development
GO:0003002	1.636e-06	6.192	24 HNF1B, HOXA10, HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC5, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, LMX1B, RIPPLY1, TDGF1, TULP3, ZBTB16	177	regionalization
GO:0051179	2.015e-06	90.71	138 ABCA4, ABCC4, ADIPOQ, AFP, ALOX12, ANO7, AP1M2, AP3S1, AQP2, AQP6, ARSB, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BDKRB2, BTC, CCL25, CD3G, CLCN5, CLCNKA, CLDN16, CSN2, CUBN, CYP27B1, DAB2, DPP4, EGF, F2RL1, FAM3D, FKBP15, FLNB, FOLR1, FXYD2, GAL, GOSR2, HNF1B, HOXA5, HOXA7, IL12B, KCNJ1, KCNJ16, KCNQ1, KCNS3, LMX1B, NPHS2, NPR3, NRG1, OXT, PARD6B, PKHD1, PLAU, PLCG2, PNLIP, PPY, PRLR, PRSS8, RAB19, RAB25, RAB34, RAB38, RAB7L1, RHBG, RHCG, SCAMP2, SCIN, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC23A3, SLC25A45, SLC26A7, SLC30A2, SLC34A1, SLC34A3, SLC35F2, SLC37A4, SLC38A8, SLC39A5, SLC3A2, SLC4A1, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, SLCO4C1, SPNS3, STRA6, TCN2, TDGF1, TMED4, TNFSF15, TPCN1, TRAF3IP2, TRPM6, TRPV4, UCN3, VAV3, VDR, WNK4, ZBTB16	2593	localization
GO:0015849	5.461e-06	4.723	20 BDKRB2, FOLR1, OXT, SLC10A2, SLC13A3, SLC16A4, SLC22A12, SLC22A4, SLC22A5, SLC22A6, SLC23A1, SLC26A7, SLC38A8, SLC3A2, SLC6A19, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9	135	organic acid transport
GO:0046903	1.640e-05	13.92	36 ADIPOQ, AQP2, AQP6, ATP6V0A4, ATP6V1B1, BDKRB2, BTC, CLCN5, CLCNKA, CLDN16, DAB2, EGF, FAM3D, GAL, HNF1B, KCNJ1, KCNQ1, NPHS2, NPR3, NRG1, OXT, PPY, PRLR, SCIN, SCNN1A, SCNN1B, SCNN1G, SCTR, SLC22A2, SLC22A4, SLC6A3, TNFSF15, TRAF3IP2, TRPV4, UCN3, VDR	398	secretion
GO:0046942	2.062e-05	4.688	19 BDKRB2, FOLR1, OXT, SLC10A2, SLC13A3, SLC16A4, SLC22A4, SLC22A5, SLC22A6, SLC23A1, SLC26A7, SLC38A8, SLC3A2, SLC6A19, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9	134	carboxylic acid transport
GO:0048705	2.301e-05	3.393	16 HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, TFAP2A, TULP3	97	skeletal system morphogenesis
GO:0007389	1.018e-04	7.906	24 HNF1B, HOXA10, HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC5, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, LMX1B, RIPPLY1, TDGF1, TULP3, ZBTB16	226	pattern specification process
GO:0048598	1.092e-04	9.656	27 ADIPOQ, CELSR1, FOXI1, GCM1, HIRA, HMX2, HNF1B, HOXA10, HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXD10, HOXD3, HOXD4, HOXD9, MAP3K7, TDGF1, TFAP2A, TINAG, TULP3, ZBTB16	276	embryonic morphogenesis
GO:0048562	4.804e-04	3.883	15 FOXI1, HMX2, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXD10, HOXD3, HOXD4, HOXD9, TFAP2A, TULP3	111	embryonic organ morphogenesis
GO:0015837	4.844e-04	4.373	16 FOLR1, OXT, RHCG, SLC18A1, SLC22A4, SLC22A5, SLC38A8, SLC3A2, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9	125	amine transport
GO:0006820	8.412e-04	2.694	12 SLC10A2, SLC13A1, SLC13A3, SLC22A11, SLC22A12, SLC22A6, SLC22A8, SLC26A7, SLC34A1, SLC34A3, SLC4A1, WNK4	77	anion transport
GO:0030855	1.226e-03	4.758	16 ALOX12, CYP27B1, EHF, ELF5, FOXN1, FZD2, HOXA5, HOXA7, HOXB5, KRT3, PAX2, RHCG, SFN, TFCP2L1, UPK1B, UPK2	136	epithelial cell differentiation
GO:0032501	1.367e-03	115.4	152 ABCA4, ADIPOQ, AFP, ALOX12, AQP2, AQP6, ARSB, ATP1A1, ATP6V0A4, ATP6V1B1, BDKRB2, BICC1, BMP3, BPGM, BTC, CALCB, CALCR, CASR, CD226, CD59, CDH3, CELSR1, CLCN5, CLCNKA, CLDN16, CLDN19, COCH, COL19A1, COL4A3, CUBN, CYP24A1, CYP27B1, DAB2, DMRT2, EGF, EHF, ELF5, ERMP1, EVC, F2RL1, FLNB, FOXI1, FOXL1, FOXN1, FZD2, GAL, GCM1, GSS, HECA, HIRA, HMX2, HNF1B, HOXA10, HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB6, HOXB7, HOXC10, HOXC5, HOXC6, HOXC8, HOXC9, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, HSD11B2, HSF4, HTR1D, IL12B, INSRR, KCNJ1, KCNQ1, KL, KRT3, LGMN, LMX1B, LUC7L, MAP3K7, MATN3, MMP13, MYO3B, NHS, NOX4, NPHS2, NPR3, NRG1, NTRK1, OR10Q1, OR51E1, OR51I2, OTOA, OXT, PAQR5, PARD6B, PAX2, PAX8, PKHD1, PLAU, PLCG2, PNLIP, PPY, PRLR, PTH1R, REG3A, REN, RHCG, RIPPLY1, SCIN, SCNN1A, SCNN1B, SCNN1G, SCTR, SFN, SHISA2, SIM1, SIM2, SLC12A6, SLC22A2, SLC22A4, SLC22A5, SLC34A1, SLC6A3, SLC6A4, SLCO4C1, SOX14, TACSTD2, TBX19, TDGF1, TFAP2A, TFAP2B, TFCP2L1, TINAG, TNFSF15, TULP3, UCMA, UPK1B, UPK2, USH1C, VAV3, VDR, WARS2, WFDC2, WNT9B, ZBTB16, ZSCAN2	3300	multicellular organismal process
GO:0060429	2.172e-03	9.726	24 ALOX12, CELSR1, CYP27B1, EHF, ELF5, FOXN1, FZD2, GCM1, HNF1B, HOXA11, HOXA5, HOXA7, HOXB5, KRT3, MAP3K7, PAX2, RHCG, SFN, TFAP2A, TFCP2L1, TULP3, UPK1B, UPK2, VDR	278	epithelium development
GO:0015695	2.359e-03	0.6997	6 RHBG, RHCG, SLC22A13, SLC22A2, SLC22A4, SLC22A5	20	organic cation transport
GO:0009790	4.294e-03	17.77	35 ADIPOQ, CELSR1, CUBN, DAB2, FOXI1, GCM1, HIRA, HMX2, HNF1B, HOXA10, HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC5, HOXC6, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, LMX1B, MAP3K7, NRG1, RIPPLY1, TDGF1, TFAP2A, TINAG, TULP3, ZBTB16	508	embryo development
GO:0006865	4.562e-03	2.799	11 FOLR1, SLC22A4, SLC22A5, SLC38A8, SLC3A2, SLC6A19, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9	80	amino acid transport
GO:0050801	5.621e-03	12.45	27 ADIPOQ, ALOX12, ATP6V0A4, ATP6V1B1, BDKRB2, CALCB, CALCR, CASR, CCL23, CLDN16, CXCR3, CYP27B1, F2RL1, FZD2, KCNQ1, OXT, PLCG2, RHCG, SLC30A2, SLC34A1, SLC34A3, SLC4A1, SLC7A8, SLC9A3, SLC9A4, TRPV4, VDR	356	ion homeostasis
GO:0051180	6.001e-03	0.8396	6 CUBN, FOLR1, SLC22A4, SLC22A5, SLC23A1, TCN2	24	vitamin transport
GO:0055080	6.813e-03	8.676	21 ATP6V0A4, ATP6V1B1, BDKRB2, CALCB, CALCR, CASR, CCL23, CLDN16, CXCR3, CYP27B1, F2RL1, FZD2, OXT, PLCG2, RHCG, SLC30A2, SLC7A8, SLC9A3, SLC9A4, TRPV4, VDR	248	cation homeostasis
GO:0016338	6.817e-03	0.5597	5 CLDN10, CLDN15, CLDN16, CLDN19, CLDN8	16	calcium-independent cell-cell adhesion
GO:0070561	6.948e-03	0.1399	3 CYP24A1, CYP27B1, VDR	4	vitamin D receptor signaling pathway
GO:0071305	6.948e-03	0.1399	3 CYP24A1, CYP27B1, VDR	4	cellular response to vitamin D
GO:0042221	7.284e-03	40.23	63 ADIPOQ, AFP, ALOX12, AP3S1, AQP2, ARSB, ATP1A1, BCAR3, BDKRB2, CALCR, CASR, CCL23, CCL25, CCRL1, CDH3, COL4A3, CUBN, CXCR3, CYP24A1, CYP27B1, DDC, DEFB4A, DPP4, F2RL1, FMO1, FMO4, GAL, GATA3, GLYAT, GSS, HNF1B, HSD11B2, HTR1D, KCNQ1, MAT2A, MSRA, OXT, PARP1, PLAU, PLCG2, PNLIP, PRSS8, REN, SCNN1B, SCNN1G, SLC15A2, SLC18A1, SLC22A12, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC34A1, SLC34A3, SLC6A19, SLC6A3, SLC6A4, SLC7A8, SLC9A3, TRPM6, UCN3, VDR, WNT9B	1150	response to chemical stimulus
GO:0042592	7.589e-03	22.88	41 ADIPOQ, ALOX12, AQP2, ATP6V0A4, ATP6V1B1, BDKRB2, BPGM, BTC, CALCB, CALCR, CASR, CCL23, CLDN16, CUBN, CXCR3, CYP27B1, F2RL1, FZD2, GYLTL1B, HOXA5, HOXB6, KCNQ1, NOX4, NPR3, OXT, PARP1, PKHD1, PLCG2, RHCG, SLC22A12, SLC22A5, SLC30A2, SLC34A1, SLC34A3, SLC37A4, SLC4A1, SLC7A8, SLC9A3, SLC9A4, TRPV4, VDR	654	homeostatic process
GO:0015711	9.709e-03	1.294	7 SLC10A2, SLC13A3, SLC22A11, SLC22A12, SLC22A6, SLC22A8, SLC26A7	37	organic anion transport
GO:0030878	1.002e-02	0.3498	4 HOXA3, HOXA5, HOXD3, PAX8	10	thyroid gland development
GO:0043009	1.102e-02	11.06	24 CELSR1, CUBN, DAB2, GCM1, HNF1B, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC5, HOXC6, HOXD10, HOXD3, HOXD4, HOXD9, LMX1B, MAP3K7, RIPPLY1, TDGF1, TFAP2A, TULP3	316	chordate embryonic development
GO:0009792	1.227e-02	11.16	24 CELSR1, CUBN, DAB2, GCM1, HNF1B, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC5, HOXC6, HOXD10, HOXD3, HOXD4, HOXD9, LMX1B, MAP3K7, RIPPLY1, TDGF1, TFAP2A, TULP3	319	embryo development ending in birth or egg hatching
GO:0048568	1.437e-02	6.122	16 FOXI1, GCM1, HMX2, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXD10, HOXD3, HOXD4, HOXD9, TFAP2A, TULP3	175	embryonic organ development
GO:0048878	1.518e-02	15.6	30 ADIPOQ, ALOX12, ATP6V0A4, ATP6V1B1, BDKRB2, BTC, CALCB, CALCR, CASR, CCL23, CLDN16, CXCR3, CYP27B1, F2RL1, FZD2, KCNQ1, NPR3, OXT, PLCG2, RHCG, SLC30A2, SLC34A1, SLC34A3, SLC37A4, SLC4A1, SLC7A8, SLC9A3, SLC9A4, TRPV4, VDR	446	chemical homeostasis
GO:0048513	1.717e-02	52.9	76 ADIPOQ, AFP, ALOX12, AQP6, BMP3, BPGM, CALCR, CELSR1, COL19A1, COL4A3, CYP27B1, DMRT2, EGF, EHF, ELF5, ERMP1, EVC, FLNB, FOXI1, FOXL1, FOXN1, FZD2, GCM1, HECA, HMX2, HNF1B, HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, HSF4, IL12B, KL, KRT3, LMX1B, LUC7L, MAP3K7, NHS, NOX4, NRG1, NTRK1, OXT, PAX2, PAX8, PKHD1, PLAU, PLCG2, PRLR, REN, RHCG, SCIN, SFN, SLC12A6, SLC6A3, SLC6A4, TBX19, TDGF1, TFAP2A, TFCP2L1, TULP3, UPK1B, UPK2, VAV3, VDR, WARS2, ZBTB16	1512	organ development
GO:0007589	1.925e-02	1.924	8 BTC, NPR3, OXT, PRLR, SLC22A2, SLC22A4, SLC6A3, VDR	55	body fluid secretion
GO:0009954	2.050e-02	0.7347	5 HOXA10, HOXA11, HOXC10, HOXD10, HOXD9	21	proximal/distal pattern formation
GO:0009636	2.300e-02	1.994	8 DDC, GLYAT, HTR1D, SLC22A8, SLC23A1, SLC6A4, SLC7A8, TRPM6	57	response to toxin
GO:0009651	2.414e-02	0.4548	4 AQP2, BDKRB2, OXT, TRPV4	13	response to salt stress
GO:0015804	2.414e-02	0.4548	4 SLC3A2, SLC7A10, SLC7A8, SLC7A9	13	neutral amino acid transport
GO:0030879	2.504e-02	2.519	9 EGF, ELF5, HOXA5, HOXD9, NRG1, PRLR, SLC6A3, TDGF1, VDR	72	mammary gland development
GO:0065008	2.983e-02	47.37	68 ADIPOQ, AFP, ALOX12, AQP2, ARPC5L, ATP1A1, ATP6V0A4, ATP6V1B1, BDKRB2, BPGM, BTC, CALCB, CALCR, CASR, CCL23, CD59, CDHR2, CLDN16, CUBN, CXCR3, CYP27B1, DAB2, ESM1, F2RL1, FAM3D, FLNB, FZD2, GAL, GYLTL1B, HNF1B, HOXA5, HOXB6, HSD11B2, KCNQ1, NET1, NOX4, NPR3, NRG1, OXT, PAPPA2, PARP1, PKHD1, PLAU, PLCG2, PRLR, REN, RHCG, SCIN, SFN, SLC22A12, SLC22A2, SLC22A4, SLC22A5, SLC30A2, SLC34A1, SLC34A3, SLC37A4, SLC3A2, SLC4A1, SLC6A3, SLC6A4, SLC7A8, SLC9A3, SLC9A4, TRPV4, UCN3, VDR, VIL1	1354	regulation of biological quality
GO:0003074	3.187e-02	0.06997	2 BTC, OXT	2	regulation of diuresis
GO:0031943	3.187e-02	0.06997	2 ATP1A1, GAL	2	regulation of glucocorticoid metabolic process
GO:0060433	3.187e-02	0.06997	2 HOXA5, TULP3	2	bronchus development
GO:0048731	3.372e-02	69.69	93 ADIPOQ, AFP, ALOX12, AQP6, ARSB, BMP3, BPGM, CALCR, CELSR1, COL19A1, COL4A3, CYP27B1, DMRT2, EGF, EHF, ELF5, ERMP1, EVC, FLNB, FOXI1, FOXL1, FOXN1, FZD2, GAL, GCM1, GSS, HECA, HMX2, HNF1B, HOXA10, HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC5, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, HSF4, IL12B, KL, KRT3, LMX1B, LUC7L, MAP3K7, MATN3, NHS, NOX4, NPR3, NRG1, NTRK1, OXT, PARD6B, PAX2, PAX8, PKHD1, PLAU, PLCG2, PRLR, PTH1R, REN, RHCG, SCIN, SFN, SIM1, SIM2, SLC12A6, SLC6A3, SLC6A4, SOX14, TBX19, TDGF1, TFAP2A, TFAP2B, TFCP2L1, TINAG, TULP3, UPK1B, UPK2, VAV3, VDR, WARS2, WNT9B, ZBTB16	1992	system development
GO:0030146	3.404e-02	0.2449	3 BTC, NPR3, OXT	7	diuresis
GO:0055065	4.225e-02	6.367	15 BDKRB2, CALCB, CALCR, CASR, CCL23, CLDN16, CXCR3, CYP27B1, F2RL1, FZD2, OXT, PLCG2, SLC7A8, TRPV4, VDR	182	metal ion homeostasis
GO:0032502	4.652e-02	90.82	115 ADIPOQ, AFP, ALDH6A1, ALOX12, AQP2, AQP6, ARSB, BICC1, BMP3, BPGM, BTC, CALCR, CASR, CELSR1, COL19A1, COL4A3, CUBN, CYP24A1, CYP27B1, DAB2, DMRT2, EGF, EHF, ELF5, ERMP1, EVC, FLNB, FOXI1, FOXL1, FOXN1, FZD2, GAL, GATA3, GCM1, GSS, HECA, HIRA, HMX2, HNF1B, HOXA10, HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB6, HOXB7, HOXC10, HOXC5, HOXC6, HOXC8, HOXC9, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, HSF4, IL12B, INSRR, KL, KRT3, LMX1B, LUC7L, MAP3K7, MATN3, NHS, NOX4, NPR3, NRG1, NTRK1, OXT, PAPPA2, PAQR5, PARD6B, PAX2, PAX8, PKHD1, PLAU, PLCG2, PNLIP, PRLR, PTH1R, REG3A, REN, RHCG, RIPPLY1, SCIN, SFN, SHISA2, SIM1, SIM2, SLC12A6, SLC6A3, SLC6A4, SLCO4C1, SOX14, TBX19, TDGF1, TFAP2A, TFAP2B, TFCP2L1, TINAG, TULP3, UCMA, UPK1B, UPK2, VAV3, VDR, WARS2, WNT9B, ZBTB16, ZSCAN2	2596	developmental process
GO:0007351	4.693e-02	0.2799	3 HOXB6, HOXD8, TDGF1	8	tripartite regional subdivision
GO:0008595	4.693e-02	0.2799	3 HOXB6, HOXD8, TDGF1	8	anterior/posterior axis specification, embryo
GO:0015893	4.693e-02	0.2799	3 SLC15A2, SLC18A1, SLC22A5	8	drug transport
GO:0007275	4.716e-02	83.47	107 ADIPOQ, AFP, ALOX12, AQP6, ARSB, BICC1, BMP3, BPGM, CALCR, CELSR1, COL19A1, COL4A3, CUBN, CYP27B1, DAB2, DMRT2, EGF, EHF, ELF5, ERMP1, EVC, FLNB, FOXI1, FOXL1, FOXN1, FZD2, GAL, GCM1, GSS, HECA, HIRA, HMX2, HNF1B, HOXA10, HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB6, HOXB7, HOXC10, HOXC5, HOXC6, HOXC8, HOXC9, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, HSF4, IL12B, INSRR, KL, KRT3, LMX1B, LUC7L, MAP3K7, MATN3, NHS, NOX4, NPR3, NRG1, NTRK1, OXT, PAQR5, PARD6B, PAX2, PAX8, PKHD1, PLAU, PLCG2, PNLIP, PRLR, PTH1R, REG3A, REN, RHCG, RIPPLY1, SCIN, SFN, SHISA2, SIM1, SIM2, SLC12A6, SLC6A3, SLC6A4, SLCO4C1, SOX14, TBX19, TDGF1, TFAP2A, TFAP2B, TFCP2L1, TINAG, TULP3, UPK1B, UPK2, VAV3, VDR, WARS2, WNT9B, ZBTB16, ZSCAN2	2386	multicellular organismal development
GO:0009888	4.726e-02	21.87	36 ALOX12, BMP3, CELSR1, COL19A1, CYP27B1, EHF, ELF5, EVC, FOXN1, FZD2, GCM1, HNF1B, HOXA11, HOXA3, HOXA5, HOXA7, HOXB5, HOXD10, HOXD3, HOXD9, KL, KRT3, LUC7L, MAP3K7, NRG1, PAX2, PLAU, RHCG, SFN, TDGF1, TFAP2A, TFCP2L1, TULP3, UPK1B, UPK2, VDR	625	tissue development

Id	Pvalue	ExpCount	Count	Size	Term
GO:0045177	7.296e-20	5.962	40 ACY3, AKR1A1, AQP2, ATP6V0A4, ATP6V0D2, ATP6V1B1, CDHR2, CLCN5, CUBN, DPEP1, DPP4, EPCAM, LGMN, NRG1, OTOA, PARD6B, PKHD1, PROM2, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC12A1, SLC12A3, SLC22A11, SLC22A12, SLC22A4, SLC22A5, SLC23A1, SLC34A3, SLC3A2, SLC4A9, SLC5A12, SLC5A8, SLC9A3, SLC9A4, TRPM6, UMOD, USH1C	170	apical part of cell
GO:0016324	9.634e-19	4.734	35 ACY3, AKR1A1, AQP2, ATP6V0A4, ATP6V0D2, ATP6V1B1, CDHR2, CUBN, DPEP1, DPP4, EPCAM, NRG1, OTOA, PKHD1, PROM2, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC12A1, SLC12A3, SLC22A11, SLC22A12, SLC22A4, SLC22A5, SLC23A1, SLC34A3, SLC3A2, SLC5A12, SLC5A8, SLC9A3, SLC9A4, TRPM6, UMOD	135	apical plasma membrane
GO:0044459	1.177e-12	55.83	114 ABCA4, ACY3, AKR1A1, ANO7, AQP2, AQP6, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, BDKRB2, BSND, CALCR, CASR, CASS4, CCRL1, CD226, CD3G, CD59, CDH3, CDHR2, CELSR1, CLCN5, CLCNKA, CLDN10, CLDN15, CLDN16, CLDN19, CLDN24, CLDN8, CUBN, CXCR3, DPEP1, DPP4, EPCAM, F2RL1, FOLR1, FXYD2, FZD2, GPR137B, HTR1D, INSRR, KCNJ1, KCNJ16, KCNQ1, KCNS3, KL, MME, MTNR1A, NCSTN, NOX4, NPHS2, NRG1, NTRK1, OTOA, PARD6B, PKHD1, PROM2, PSD3, PTH1R, RAB25, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SCTR, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A3, SLC15A2, SLC16A4, SLC17A3, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC26A7, SLC34A1, SLC34A3, SLC39A5, SLC3A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, SLCO4C1, STARD8, TACSTD2, TDGF1, TMPRSS2, TNFSF15, TRPM6, TRPV4, UMOD, UPK2, WNK4	1592	plasma membrane part
GO:0031224	1.990e-12	130.3	203 ABCA4, ABCC4, ANO7, AQP2, AQP6, ATP10D, ATP12A, ATP1A1, ATP6V0A4, B3GAT2, B4GALNT2, BDKRB2, BSND, BTC, C12orf59, C17orf78, C18orf1, C1orf186, C9orf71, CA12, CALCR, CASR, CCRL1, CD164L2, CD226, CD3G, CD59, CDCP1, CDH16, CDH3, CDHR2, CELSR1, CLCN5, CLCNKA, CLDN10, CLDN15, CLDN16, CLDN19, CLDN24, CLDN8, CLRN3, CWH43, CXCR3, DCBLD1, DPEP1, DPP4, EGF, EPCAM, ERMP1, EVC, F2RL1, FAM119B, FAM151A, FAM174A, FLNB, FMO1, FMO4, FOLR1, FRAS1, FXYD2, FZD2, GALNT11, GALNT14, GCNT3, GDPD3, GFRAL, GGT6, GOSR2, GP2, GPR110, GPR137B, GPRC6A, GYLTL1B, HTR1D, ILDR1, INSRR, KCNJ1, KCNJ16, KCNQ1, KCNS3, KL, LETM1, LRRC19, MARCH6, MARVELD3, MME, MS4A10, MS4A8B, MSLNL, MTNR1A, NCSTN, NOX4, NPHS2, NPR3, NRG1, NTRK1, OR10Q1, OR51E1, OR51I2, OTOA, OXGR1, PAQR5, PDZK1IP1, PKHD1, PRLR, PROM2, PRSS8, PTH1R, PTPLAD2, RELT, RHBG, RHCG, SCAMP2, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SHISA2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC23A3, SLC25A45, SLC26A7, SLC30A2, SLC34A1, SLC34A3, SLC35F2, SLC37A4, SLC38A8, SLC39A5, SLC3A2, SLC44A3, SLC44A4, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, SLCO4C1, SPNS3, SPTLC3, STRA6, SUSD2, TAAR2, TACSTD2, TDGF1, TM7SF3, TMED4, TMEM106C, TMEM139, TMEM171, TMEM174, TMEM179B, TMEM27, TMEM61, TMEM72, TMEM86A, TMIGD1, TMPRSS13, TMPRSS2, TNFSF15, TPCN1, TRPM6, TRPV4, TSPAN1, UMOD, UPK1B, UPK2, XPNPEP2	3717	intrinsic to membrane
GO:0005886	2.239e-11	92.02	156 ABCA4, ABCC4, ACY3, AKR1A1, ALOX12, ANO7, AQP2, AQP6, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BDKRB2, BSND, BTC, C18orf1, CALCR, CASR, CASS4, CCRL1, CD226, CD3G, CD59, CDCP1, CDH16, CDH3, CDHR2, CELSR1, CLCN5, CLCNKA, CLDN10, CLDN15, CLDN16, CLDN19, CLDN24, CLDN8, CUBN, CXCR3, DPEP1, DPP4, EGF, EPCAM, F2RL1, FGFBP1, FLNB, FOLR1, FRAS1, FXYD2, FZD2, GFRAL, GP2, GPR110, GPR137B, GPRC6A, HTR1D, ILDR1, INSRR, KCNJ1, KCNJ16, KCNQ1, KCNS3, KL, MME, MTNR1A, NCSTN, NEU1, NOX4, NPHS2, NRG1, NTRK1, OR10Q1, OR51E1, OR51I2, OTOA, OXGR1, PARD6B, PKHD1, PLA2G3, PLAU, PLCG2, PROM2, PRSS8, PSD3, PTH1R, RAB19, RAB25, RAB38, RAB7L1, RELT, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SCTR, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC26A7, SLC34A1, SLC34A3, SLC39A5, SLC3A2, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, SLCO4C1, STARD8, STRA6, TAAR2, TACSTD2, TDGF1, TM7SF3, TMPRSS2, TNFSF15, TRPM6, TRPV4, TULP3, UMOD, UPK2, VAV3, WNK4, XPNPEP2, ZBTB16	2624	plasma membrane
GO:0016021	3.488e-11	127.6	196 ABCA4, ABCC4, ANO7, AQP2, AQP6, ATP10D, ATP12A, ATP1A1, ATP6V0A4, B3GAT2, B4GALNT2, BDKRB2, BSND, BTC, C12orf59, C17orf78, C18orf1, C1orf186, C9orf71, CA12, CALCR, CASR, CCRL1, CD164L2, CD226, CD3G, CDCP1, CDH16, CDH3, CDHR2, CELSR1, CLCN5, CLCNKA, CLDN10, CLDN15, CLDN16, CLDN19, CLDN24, CLDN8, CLRN3, CWH43, CXCR3, DCBLD1, DPP4, EGF, EPCAM, ERMP1, EVC, F2RL1, FAM119B, FAM151A, FAM174A, FLNB, FMO1, FMO4, FOLR1, FRAS1, FXYD2, FZD2, GALNT11, GALNT14, GCNT3, GDPD3, GFRAL, GGT6, GOSR2, GPR110, GPR137B, GPRC6A, GYLTL1B, HTR1D, ILDR1, INSRR, KCNJ1, KCNJ16, KCNQ1, KCNS3, KL, LETM1, LRRC19, MARCH6, MARVELD3, MME, MS4A10, MS4A8B, MSLNL, MTNR1A, NCSTN, NOX4, NPHS2, NPR3, NRG1, NTRK1, OR10Q1, OR51E1, OR51I2, OXGR1, PAQR5, PDZK1IP1, PKHD1, PRLR, PROM2, PRSS8, PTH1R, PTPLAD2, RELT, RHBG, RHCG, SCAMP2, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SHISA2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC23A3, SLC25A45, SLC26A7, SLC30A2, SLC34A1, SLC34A3, SLC35F2, SLC37A4, SLC38A8, SLC39A5, SLC3A2, SLC44A3, SLC44A4, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, SLCO4C1, SPNS3, SPTLC3, STRA6, SUSD2, TAAR2, TACSTD2, TM7SF3, TMED4, TMEM106C, TMEM139, TMEM171, TMEM174, TMEM179B, TMEM27, TMEM61, TMEM72, TMEM86A, TMIGD1, TMPRSS13, TMPRSS2, TNFSF15, TPCN1, TRPM6, TRPV4, TSPAN1, UPK1B, UPK2	3638	integral to membrane
GO:0044425	1.820e-10	150.3	218 ABCA4, ABCC4, ACY3, AKR1A1, ANO7, AP1M2, AP3S1, AQP2, AQP6, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, B3GAT2, B4GALNT2, BDKRB2, BSND, BTC, C12orf59, C17orf78, C18orf1, C1orf186, C9orf71, CA12, CALCR, CASR, CASS4, CCRL1, CD164L2, CD226, CD3G, CD59, CDCP1, CDH16, CDH3, CDHR2, CELSR1, CLCN5, CLCNKA, CLDN10, CLDN15, CLDN16, CLDN19, CLDN24, CLDN8, CLRN3, CUBN, CWH43, CXCR3, DAB2, DCBLD1, DPEP1, DPP4, EGF, EPCAM, ERMP1, EVC, F2RL1, FAM119B, FAM151A, FAM174A, FLNB, FMO1, FMO4, FOLR1, FRAS1, FXYD2, FZD2, GALNT11, GALNT14, GCNT3, GDPD3, GFRAL, GGT6, GOSR2, GP2, GPR110, GPR137B, GPRC6A, GYLTL1B, HTR1D, ILDR1, INSRR, KCNJ1, KCNJ16, KCNQ1, KCNS3, KL, LETM1, LRRC19, MARCH6, MARVELD3, MME, MS4A10, MS4A8B, MSLNL, MTNR1A, NCSTN, NOX4, NPHS2, NPR3, NRG1, NTRK1, OR10Q1, OR51E1, OR51I2, OTOA, OXGR1, PAQR5, PARD6B, PDZK1IP1, PKHD1, PRLR, PROM2, PRSS8, PSD3, PTH1R, PTPLAD2, RAB25, RELT, RHBG, RHCG, SCAMP2, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SHISA2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC23A3, SLC25A45, SLC26A7, SLC30A2, SLC34A1, SLC34A3, SLC35F2, SLC37A4, SLC38A8, SLC39A5, SLC3A2, SLC44A3, SLC44A4, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, SLCO4C1, SPNS3, SPTLC3, STARD8, STRA6, SUSD2, TAAR2, TACSTD2, TDGF1, TM7SF3, TMED4, TMEM106C, TMEM139, TMEM171, TMEM174, TMEM179B, TMEM27, TMEM61, TMEM72, TMEM86A, TMIGD1, TMPRSS13, TMPRSS2, TNFSF15, TPCN1, TRPM6, TRPV4, TSPAN1, UMOD, UPK1B, UPK2, WNK4, XPNPEP2	4287	membrane part
GO:0016020	8.980e-08	180.5	239 ABCA4, ABCC4, ACY3, AKR1A1, ALOX12, ANO7, AP1M2, AP3S1, AQP2, AQP6, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, B3GAT2, B4GALNT2, BDKRB2, BSND, BTC, C12orf59, C17orf78, C18orf1, C1orf186, C9orf71, CA12, CALCR, CASR, CASS4, CCRL1, CD164L2, CD226, CD3G, CD59, CDCP1, CDH16, CDH3, CDHR2, CELSR1, CHDH, CLCN5, CLCNKA, CLDN10, CLDN15, CLDN16, CLDN19, CLDN24, CLDN8, CLRN3, CUBN, CWH43, CXCR3, CYP24A1, CYP27B1, DAB2, DCBLD1, DPEP1, DPP4, EGF, EPCAM, ERMP1, EVC, F2RL1, FAM119B, FAM151A, FAM174A, FGFBP1, FLNB, FMO1, FMO4, FOLR1, FRAS1, FXYD2, FZD2, GALNT11, GALNT14, GCNT3, GDPD3, GFRAL, GGT6, GOSR2, GP2, GPR110, GPR137B, GPRC6A, GYLTL1B, HTR1D, IL12B, ILDR1, INSRR, KCNJ1, KCNJ16, KCNQ1, KCNS3, KL, LETM1, LRRC19, MAP3K7, MARCH6, MARVELD3, MME, MS4A10, MS4A8B, MSLNL, MTNR1A, NCSTN, NEU1, NOX4, NPHS2, NPR3, NRG1, NTRK1, OR10Q1, OR51E1, OR51I2, OTOA, OXGR1, PAPPA2, PAQR5, PARD6B, PDZK1IP1, PKHD1, PLA2G3, PLA2G4F, PLAU, PLCG2, PRLR, PROM2, PRSS8, PSD3, PTH1R, PTPLAD2, RAB19, RAB25, RAB38, RAB7L1, RELT, REN, RHBG, RHCG, SCAMP2, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SHISA2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC23A3, SLC25A45, SLC26A7, SLC30A2, SLC34A1, SLC34A3, SLC35F2, SLC37A4, SLC38A8, SLC39A5, SLC3A2, SLC44A3, SLC44A4, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, SLCO4C1, SPNS3, SPTLC3, STARD8, STRA6, SUSD2, TAAR2, TACSTD2, TDGF1, TFCP2L1, TM7SF3, TMED4, TMEM106C, TMEM139, TMEM171, TMEM174, TMEM179B, TMEM27, TMEM61, TMEM72, TMEM86A, TMIGD1, TMPRSS13, TMPRSS2, TNFSF15, TPCN1, TRPM6, TRPV4, TSPAN1, TULP3, UMOD, UPK1B, UPK2, VAV3, WNK4, XPNPEP2, ZBTB16	5148	membrane
GO:0031226	6.820e-06	33.1	64 ABCA4, AQP6, ATP12A, ATP1A1, BDKRB2, BSND, CALCR, CASR, CCRL1, CD226, CD3G, CD59, CELSR1, CLCN5, CLCNKA, CXCR3, F2RL1, FOLR1, FXYD2, FZD2, GPR137B, HTR1D, INSRR, KCNJ1, KCNJ16, KCNQ1, KCNS3, KL, MME, MTNR1A, NCSTN, NPHS2, NTRK1, PKHD1, PTH1R, RHBG, RHCG, SCNN1G, SCTR, SLC10A2, SLC12A3, SLC15A2, SLC16A4, SLC17A3, SLC22A11, SLC22A13, SLC22A2, SLC22A4, SLC22A6, SLC22A8, SLC23A1, SLC34A1, SLC4A1, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A7, SLC7A8, SLC7A9, TACSTD2, TMPRSS2, TNFSF15, UPK2	944	intrinsic to plasma membrane
GO:0016323	8.983e-06	6.733	23 AQP2, ATP1A1, ATP6V1B1, BSND, CASS4, CLDN19, EPCAM, NOX4, PROM2, RHBG, RHCG, SLC12A6, SLC22A6, SLC22A8, SLC26A7, SLC39A5, SLC4A1, SLC4A9, SLC7A7, SLC7A8, SLC9A4, SLCO4C1, STARD8	192	basolateral plasma membrane
GO:0005887	1.453e-05	32.4	62 ABCA4, AQP6, ATP12A, ATP1A1, BDKRB2, BSND, CALCR, CASR, CCRL1, CD226, CD3G, CELSR1, CLCN5, CLCNKA, CXCR3, F2RL1, FOLR1, FXYD2, FZD2, GPR137B, HTR1D, INSRR, KCNJ1, KCNJ16, KCNQ1, KCNS3, KL, MME, MTNR1A, NCSTN, NPHS2, NTRK1, PTH1R, RHBG, RHCG, SCNN1G, SCTR, SLC10A2, SLC12A3, SLC15A2, SLC16A4, SLC17A3, SLC22A11, SLC22A13, SLC22A2, SLC22A4, SLC22A6, SLC22A8, SLC23A1, SLC34A1, SLC4A1, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A7, SLC7A8, SLC7A9, TACSTD2, TMPRSS2, TNFSF15, UPK2	924	integral to plasma membrane
GO:0031526	3.032e-05	0.8416	8 ATP6V0A4, CUBN, SLC22A12, SLC22A5, SLC34A1, SLC34A3, SLC9A3, TRPM6	24	brush border membrane
GO:0005903	8.305e-05	1.262	9 ATP6V0A4, CUBN, SLC13A1, SLC22A12, SLC22A5, SLC34A1, SLC34A3, SLC9A3, TRPM6	36	brush border
GO:0016471	9.902e-04	0.2455	4 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3	7	vacuolar proton-transporting V-type ATPase complex
GO:0031253	1.464e-03	3.191	12 ATP6V0A4, CUBN, DPEP1, DPP4, PROM2, RAB25, SLC22A12, SLC22A5, SLC34A1, SLC34A3, SLC9A3, TRPM6	91	cell projection membrane
GO:0005624	5.096e-03	21.15	38 ABCA4, ABCC4, ACY3, AQP2, ATP1A1, ATP6V1B1, B4GALNT2, CD59, CUBN, DPP4, FMO1, FMO4, FOLR1, GCNT3, GPR137B, HSD11B2, KL, MME, NCSTN, NPR3, PLCG2, PSD3, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC15A2, SLC16A4, SLC17A3, SLC18A1, SLC22A2, SLC22A6, SLC22A8, SLC23A1, SLC6A3, SLC6A4	603	membrane fraction
GO:0005923	8.872e-03	1.929	8 CLDN10, CLDN15, CLDN16, CLDN19, CLDN24, CLDN8, PARD6B, WNK4	55	tight junction
GO:0070160	8.872e-03	1.929	8 CLDN10, CLDN15, CLDN16, CLDN19, CLDN24, CLDN8, PARD6B, WNK4	55	occluding junction
GO:0005626	9.459e-03	21.95	38 ABCA4, ABCC4, ACY3, AQP2, ATP1A1, ATP6V1B1, B4GALNT2, CD59, CUBN, DPP4, FMO1, FMO4, FOLR1, GCNT3, GPR137B, HSD11B2, KL, MME, NCSTN, NPR3, PLCG2, PSD3, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC15A2, SLC16A4, SLC17A3, SLC18A1, SLC22A2, SLC22A6, SLC22A8, SLC23A1, SLC6A3, SLC6A4	626	insoluble fraction
GO:0033176	1.853e-02	0.526	4 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3	15	proton-transporting V-type ATPase complex
GO:0043296	2.231e-02	2.279	8 CLDN10, CLDN15, CLDN16, CLDN19, CLDN24, CLDN8, PARD6B, WNK4	65	apical junction complex
GO:0031225	2.292e-02	3.367	10 CD59, DPEP1, FOLR1, GP2, OTOA, PKHD1, RHBG, TDGF1, UMOD, XPNPEP2	96	anchored to membrane
GO:0000267	2.338e-02	28.93	45 ABCA4, ABCC4, ACY3, AQP2, ATP1A1, ATP6V1B1, B4GALNT2, BTC, CALCB, CCL25, CD59, CUBN, DHDH, DPP4, EGF, FMO1, FMO4, FOLR1, GCNT3, GPR137B, GSS, HSD11B2, KL, MME, NCSTN, NPR3, PLCG2, PSD3, REG3A, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC15A2, SLC16A4, SLC17A3, SLC18A1, SLC22A2, SLC22A6, SLC22A8, SLC23A1, SLC6A3, SLC6A4	825	cell fraction
GO:0016327	2.846e-02	2.385	8 CLDN10, CLDN15, CLDN16, CLDN19, CLDN24, CLDN8, PARD6B, WNK4	68	apicolateral plasma membrane
GO:0005774	3.314e-02	3.577	10 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, CUBN, NCSTN, NEU1, PLA2G4F, SLC30A2, TSPAN1	102	vacuolar membrane
GO:0044437	4.641e-02	3.787	10 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, CUBN, NCSTN, NEU1, PLA2G4F, SLC30A2, TSPAN1	108	vacuolar part

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022804	5.769e-18	9.416	49 ABCA4, ABCC4, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V1B1, CLCN5, FXYD2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC26A7, SLC34A1, SLC34A3, SLC3A2, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4	277	active transmembrane transporter activity
GO:0022857	9.213e-17	24.2	77 ABCA4, ABCC4, ANO7, AQP2, AQP6, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSND, C1orf31, CLCN5, CLCNKA, CLDN16, FXYD2, KCNJ1, KCNJ16, KCNQ1, KCNS3, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC26A7, SLC30A2, SLC34A1, SLC34A3, SLC37A4, SLC39A5, SLC3A2, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, TPCN1, TRPM6, TRPV4	712	transmembrane transporter activity
GO:0015291	8.420e-16	5.439	35 CLCN5, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC22A11, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC26A7, SLC34A1, SLC34A3, SLC3A2, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4, SLC9A3, SLC9A4	160	secondary active transmembrane transporter activity
GO:0005215	1.021e-14	31	84 ABCA4, ABCC4, ANO7, AP3S1, AQP2, AQP6, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSND, C1orf31, CLCN5, CLCNKA, CLDN16, CSN2, CUBN, FXYD2, GOSR2, KCNJ1, KCNJ16, KCNQ1, KCNS3, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC23A3, SLC26A7, SLC30A2, SLC34A1, SLC34A3, SLC37A4, SLC39A5, SLC3A2, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, SLCO4C1, TPCN1, TRPM6, TRPV4	912	transporter activity
GO:0022891	1.029e-13	22.06	67 ABCC4, ANO7, AQP2, AQP6, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, C1orf31, CLCN5, CLCNKA, CLDN16, FXYD2, KCNJ1, KCNJ16, KCNQ1, KCNS3, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC16A4, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC26A7, SLC30A2, SLC34A1, SLC34A3, SLC37A4, SLC39A5, SLC3A2, SLC4A1, SLC4A9, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, TPCN1, TRPM6, TRPV4	649	substrate-specific transmembrane transporter activity
GO:0022892	8.394e-12	25.63	69 ABCA4, ABCC4, ANO7, AP3S1, AQP2, AQP6, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, C1orf31, CLCN5, CLCNKA, CLDN16, FXYD2, KCNJ1, KCNJ16, KCNQ1, KCNS3, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC16A4, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC26A7, SLC30A2, SLC34A1, SLC34A3, SLC37A4, SLC39A5, SLC3A2, SLC4A1, SLC4A9, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9, SLC9A3, SLC9A4, TPCN1, TRPM6, TRPV4	754	substrate-specific transporter activity
GO:0015075	1.007e-11	19.21	58 ABCC4, ANO7, AQP6, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, C1orf31, CLCN5, CLCNKA, CLDN16, FXYD2, KCNJ1, KCNJ16, KCNQ1, KCNS3, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC17A3, SLC22A11, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A1, SLC26A7, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC3A2, SLC4A1, SLC4A9, SLC6A19, SLC6A3, SLC6A4, SLC7A8, SLC9A3, SLC9A4, TPCN1, TRPM6, TRPV4	565	ion transmembrane transporter activity
GO:0015293	2.575e-10	3.637	23 SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A11, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC22A4, SLC22A5, SLC23A1, SLC34A1, SLC34A3, SLC5A12, SLC5A8, SLC6A19, SLC6A3, SLC6A4	107	symporter activity
GO:0008324	1.228e-08	14.85	44 ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, C1orf31, CLDN16, FXYD2, KCNJ1, KCNJ16, KCNQ1, KCNS3, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC17A3, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC23A1, SLC30A2, SLC34A3, SLC39A5, SLC3A2, SLC6A19, SLC6A3, SLC6A4, SLC7A8, SLC9A3, SLC9A4, TPCN1, TRPM6, TRPV4	437	cation transmembrane transporter activity
GO:0008509	2.907e-07	4.011	20 ABCC4, ANO7, AQP6, BSND, CLCN5, CLCNKA, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC22A11, SLC22A6, SLC22A8, SLC26A7, SLC34A1, SLC34A3, SLC4A1, SLC4A9	118	anion transmembrane transporter activity
GO:0022890	8.639e-07	5.609	23 ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, C1orf31, CLDN16, FXYD2, RHBG, RHCG, SLC10A2, SLC13A1, SLC13A3, SLC17A3, SLC22A4, SLC22A5, SLC23A1, SLC34A3, SLC6A19, SLC6A3, SLC6A4, SLC9A3, SLC9A4	165	inorganic cation transmembrane transporter activity
GO:0015297	2.072e-06	1.836	13 CLCN5, SLC22A11, SLC22A4, SLC22A6, SLC22A8, SLC26A7, SLC3A2, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC9A3, SLC9A4	54	antiporter activity
GO:0015101	3.271e-06	0.4079	7 RHBG, RHCG, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC7A8	12	organic cation transmembrane transporter activity
GO:0005275	1.218e-05	2.141	13 SLC13A3, SLC18A1, SLC22A4, SLC22A5, SLC3A2, SLC6A19, SLC6A3, SLC6A4, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9	63	amine transmembrane transporter activity
GO:0015077	1.900e-05	4.283	18 ATP12A, ATP1A1, ATP6V0A4, ATP6V0D2, ATP6V1B1, C1orf31, FXYD2, SLC10A2, SLC13A1, SLC13A3, SLC17A3, SLC23A1, SLC34A3, SLC6A19, SLC6A3, SLC6A4, SLC9A3, SLC9A4	126	monovalent inorganic cation transmembrane transporter activity
GO:0015294	6.214e-05	2.481	13 SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC17A3, SLC23A1, SLC34A3, SLC6A19, SLC6A3, SLC6A4	73	solute:cation symporter activity
GO:0015300	6.995e-05	1.428	10 SLC22A11, SLC22A4, SLC22A6, SLC22A8, SLC26A7, SLC3A2, SLC4A1, SLC4A9, SLC9A3, SLC9A4	42	solute:solute antiporter activity
GO:0043565	1.546e-04	15.64	36 EHF, ELF5, ESRRB, FOXI1, FOXL1, FOXN1, GATA3, HMX2, HNF1B, HOXA10, HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB6, HOXB7, HOXC10, HOXC5, HOXC6, HOXC8, HOXC9, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, HSF4, LMX1B, PAX2, PAX8, SOX14, TFAP2B, VDR	460	sequence-specific DNA binding
GO:0005342	2.431e-04	2.413	12 SLC10A2, SLC13A3, SLC16A4, SLC22A12, SLC26A7, SLC3A2, SLC6A19, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9	71	organic acid transmembrane transporter activity
GO:0003700	3.792e-04	24.07	47 DMRT2, EHF, ELF5, ESRRB, FOXI1, FOXL1, FOXN1, GATA3, GCM1, GRHL2, HIRA, HMX2, HNF1B, HOXA10, HOXA11, HOXA2, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB6, HOXB7, HOXC10, HOXC5, HOXC6, HOXC8, HOXC9, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, HSF4, IRF5, LMX1B, PAX8, SIM1, SIM2, TBX19, TFAP2A, TFAP2B, TFCP2L1, TFEC, VDR, ZBTB16, ZSCAN2	708	sequence-specific DNA binding transcription factor activity
GO:0015380	4.647e-04	0.5439	6 SLC22A11, SLC22A6, SLC22A8, SLC26A7, SLC4A1, SLC4A9	16	anion exchanger activity
GO:0015081	6.073e-04	2.243	11 ATP1A1, FXYD2, SLC10A2, SLC13A1, SLC13A3, SLC17A3, SLC23A1, SLC34A3, SLC6A19, SLC6A3, SLC6A4	66	sodium ion transmembrane transporter activity
GO:0015301	6.601e-04	0.5779	6 SLC22A11, SLC22A6, SLC22A8, SLC26A7, SLC4A1, SLC4A9	17	anion:anion antiporter activity
GO:0046943	1.012e-03	2.379	11 SLC10A2, SLC13A3, SLC16A4, SLC26A7, SLC3A2, SLC6A19, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9	70	carboxylic acid transmembrane transporter activity
GO:0005452	1.288e-03	0.4079	5 SLC22A11, SLC22A6, SLC22A8, SLC4A1, SLC4A9	12	inorganic anion exchanger activity
GO:0015238	1.288e-03	0.4079	5 SLC15A2, SLC18A1, SLC22A5, SLC47A1, SLC47A2	12	drug transmembrane transporter activity
GO:0046873	1.366e-03	3.875	14 ATP12A, ATP1A1, CLDN16, FXYD2, SLC10A2, SLC13A1, SLC13A3, SLC17A3, SLC23A1, SLC34A3, SLC39A5, SLC6A19, SLC6A3, SLC6A4	114	metal ion transmembrane transporter activity
GO:0015296	2.124e-03	1.02	7 SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC34A3	30	anion:cation symporter activity
GO:0015103	2.576e-03	1.054	7 AQP6, SLC13A1, SLC17A3, SLC26A7, SLC34A1, SLC34A3, SLC4A1	31	inorganic anion transmembrane transporter activity
GO:0015171	7.993e-03	1.7	8 SLC13A3, SLC3A2, SLC6A19, SLC7A10, SLC7A13, SLC7A7, SLC7A8, SLC7A9	50	amino acid transmembrane transporter activity
GO:0015175	8.196e-03	0.6118	5 SLC3A2, SLC6A19, SLC7A10, SLC7A8, SLC7A9	18	neutral amino acid transmembrane transporter activity
GO:0004046	1.084e-02	0.17	3 ACY1, ACY3, ASPA	5	aminoacylase activity
GO:0008504	1.084e-02	0.17	3 SLC18A1, SLC6A3, SLC6A4	5	monoamine transmembrane transporter activity
GO:0015491	2.373e-02	0.4759	4 SLC22A4, SLC3A2, SLC9A3, SLC9A4	14	cation:cation antiporter activity
GO:0015280	2.743e-02	0.2379	3 SCNN1A, SCNN1B, SCNN1G	7	amiloride-sensitive sodium channel activity
GO:0030506	2.743e-02	0.2379	3 RHBG, RHCG, SLC4A1	7	ankyrin binding
GO:0050699	3.511e-02	0.5439	4 DAZAP2, SCNN1A, SCNN1B, SCNN1G	16	WW domain binding
GO:0015377	3.813e-02	0.2719	3 SLC12A1, SLC12A3, SLC12A6	8	cation:chloride symporter activity
GO:0016820	4.140e-02	2.855	9 ABCA4, ABCC4, ATP10D, ATP12A, ATP1A1, ATP6V0A4, ATP6V1B1, ATP6V1G3, FXYD2	84	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016709	4.238e-02	0.5779	4 CYP24A1, CYP27B1, FMO1, FMO4	17	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

Id	Pvalue	ExpCount	Count	Size	Term
04960	3.664e-04	1.101	8 ATP1A1, FXYD2, HSD11B2, KCNJ1, SCNN1A, SCNN1B, SCNN1G, SFN	33	Aldosterone-regulated sodium reabsorption
04966	1.156e-02	0.7007	5 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, SLC4A1	21	Collecting duct acid secretion
05110	3.330e-02	1.335	6 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, KCNQ1, PLCG2	40	Vibrio cholerae infection

No enriched terms

No enriched terms

Entrez genes

A2LD1AIG2-like domain 1 (ENSG00000134864), score: 0.64 AADATaminoadipate aminotransferase (ENSG00000109576), score: 0.43 ABCA4ATP-binding cassette, sub-family A (ABC1), member 4 (ENSG00000198691), score: 0.48 ABCC4ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ENSG00000125257), score: 0.56 ABP1amiloride binding protein 1 (amine oxidase (copper-containing)) (ENSG00000002726), score: 0.48 ACSF2acyl-CoA synthetase family member 2 (ENSG00000167107), score: 0.45 ACY1aminoacylase 1 (ENSG00000243989), score: 0.47 ACY3aspartoacylase (aminocyclase) 3 (ENSG00000132744), score: 0.45 ADIPOQadiponectin, C1Q and collagen domain containing (ENSG00000181092), score: 0.42 AFPalpha-fetoprotein (ENSG00000081051), score: 0.48 AGPHD1aminoglycoside phosphotransferase domain containing 1 (ENSG00000188266), score: 0.42 AGR3anterior gradient homolog 3 (Xenopus laevis) (ENSG00000173467), score: 0.84 AKR1A1aldo-keto reductase family 1, member A1 (aldehyde reductase) (ENSG00000117448), score: 0.4 ALDH6A1aldehyde dehydrogenase 6 family, member A1 (ENSG00000119711), score: 0.41 ALOX12arachidonate 12-lipoxygenase (ENSG00000108839), score: 0.5 ANKRD37ankyrin repeat domain 37 (ENSG00000186352), score: -0.46 ANO7anoctamin 7 (ENSG00000146205), score: 0.47 AP1M2adaptor-related protein complex 1, mu 2 subunit (ENSG00000129354), score: 0.43 AP3S1adaptor-related protein complex 3, sigma 1 subunit (ENSG00000177879), score: -0.47 AQP2aquaporin 2 (collecting duct) (ENSG00000167580), score: 0.56 AQP6aquaporin 6, kidney specific (ENSG00000086159), score: 0.51 ARGLU1arginine and glutamate rich 1 (ENSG00000134884), score: -0.48 ARPC5Lactin related protein 2/3 complex, subunit 5-like (ENSG00000136950), score: -0.42 ARSBarylsulfatase B (ENSG00000113273), score: 0.52 ARSFarylsulfatase F (ENSG00000062096), score: 0.56 ASPAaspartoacylase (ENSG00000108381), score: 0.45 ATP10DATPase, class V, type 10D (ENSG00000145246), score: 0.55 ATP12AATPase, H+/K+ transporting, nongastric, alpha polypeptide (ENSG00000075673), score: 0.9 ATP1A1ATPase, Na+/K+ transporting, alpha 1 polypeptide (ENSG00000163399), score: 0.44 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.52 ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (ENSG00000147614), score: 0.48 ATP6V1B1ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (ENSG00000116039), score: 0.48 ATP6V1G3ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 (ENSG00000151418), score: 0.39 B3GAT2beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) (ENSG00000112309), score: -0.42 B4GALNT2beta-1,4-N-acetyl-galactosaminyl transferase 2 (ENSG00000167080), score: 0.7 BCAR3breast cancer anti-estrogen resistance 3 (ENSG00000137936), score: 0.41 BDKRB2bradykinin receptor B2 (ENSG00000168398), score: 0.45 BICC1bicaudal C homolog 1 (Drosophila) (ENSG00000122870), score: 0.44 BMP3bone morphogenetic protein 3 (ENSG00000152785), score: 0.49 BNC2basonuclin 2 (ENSG00000173068), score: 0.44 BPGM2,3-bisphosphoglycerate mutase (ENSG00000172331), score: 0.42 BSNDBartter syndrome, infantile, with sensorineural deafness (Barttin) (ENSG00000162399), score: 0.51 BTCbetacellulin (ENSG00000174808), score: 0.59 C12orf59chromosome 12 open reading frame 59 (ENSG00000165685), score: 0.53 C12orf74chromosome 12 open reading frame 74 (ENSG00000214215), score: 0.48 C13orf1chromosome 13 open reading frame 1 (ENSG00000123178), score: -0.47 C14orf138chromosome 14 open reading frame 138 (ENSG00000100483), score: -0.47 C17orf78chromosome 17 open reading frame 78 (ENSG00000167230), score: 0.76 C18orf1chromosome 18 open reading frame 1 (ENSG00000168675), score: -0.4 C19orf21chromosome 19 open reading frame 21 (ENSG00000099812), score: 0.52 C19orf33chromosome 19 open reading frame 33 (ENSG00000167644), score: 0.42 C1orf106chromosome 1 open reading frame 106 (ENSG00000163362), score: 0.53 C1orf116chromosome 1 open reading frame 116 (ENSG00000182795), score: 0.66 C1orf172chromosome 1 open reading frame 172 (ENSG00000175707), score: 0.4 C1orf186chromosome 1 open reading frame 186 (ENSG00000196533), score: 0.41 C1orf31chromosome 1 open reading frame 31 (ENSG00000168275), score: -0.45 C1orf52chromosome 1 open reading frame 52 (ENSG00000162642), score: -0.4 C1orf74chromosome 1 open reading frame 74 (ENSG00000162757), score: 0.4 C22orf39chromosome 22 open reading frame 39 (ENSG00000242259), score: -0.47 C2orf40chromosome 2 open reading frame 40 (ENSG00000119147), score: 0.47 C2orf43chromosome 2 open reading frame 43 (ENSG00000118961), score: 0.41 C2orf54chromosome 2 open reading frame 54 (ENSG00000172478), score: 0.58 C4orf31chromosome 4 open reading frame 31 (ENSG00000173376), score: 0.43 C5orf32chromosome 5 open reading frame 32 (ENSG00000120306), score: 0.46 C6orf52chromosome 6 open reading frame 52 (ENSG00000137434), score: 0.43 C9orf71chromosome 9 open reading frame 71 (ENSG00000181778), score: 0.43 CA12carbonic anhydrase XII (ENSG00000074410), score: 0.49 CA13carbonic anhydrase XIII (ENSG00000185015), score: 0.66 CALCBcalcitonin-related polypeptide beta (ENSG00000175868), score: 0.45 CALCRcalcitonin receptor (ENSG00000004948), score: 0.52 CAPN13calpain 13 (ENSG00000162949), score: 0.5 CASRcalcium-sensing receptor (ENSG00000036828), score: 0.64 CASS4Cas scaffolding protein family member 4 (ENSG00000087589), score: 0.4 CCDC64Bcoiled-coil domain containing 64B (ENSG00000162069), score: 0.4 CCL23chemokine (C-C motif) ligand 23 (ENSG00000167236), score: 0.48 CCL25chemokine (C-C motif) ligand 25 (ENSG00000131142), score: 0.39 CCRL1chemokine (C-C motif) receptor-like 1 (ENSG00000129048), score: 0.4 CD164L2CD164 sialomucin-like 2 (ENSG00000174950), score: 0.71 CD226CD226 molecule (ENSG00000150637), score: 0.39 CD3GCD3g molecule, gamma (CD3-TCR complex) (ENSG00000160654), score: 0.46 CD59CD59 molecule, complement regulatory protein (ENSG00000085063), score: 0.41 CDCP1CUB domain containing protein 1 (ENSG00000163814), score: 0.48 CDH16cadherin 16, KSP-cadherin (ENSG00000166589), score: 0.52 CDH3cadherin 3, type 1, P-cadherin (placental) (ENSG00000062038), score: 0.4 CDHR2cadherin-related family member 2 (ENSG00000074276), score: 0.45 CDKL1cyclin-dependent kinase-like 1 (CDC2-related kinase) (ENSG00000100490), score: 0.44 CELSR1cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) (ENSG00000075275), score: 0.4 CHDHcholine dehydrogenase (ENSG00000016391), score: 0.4 CLCN5chloride channel 5 (ENSG00000171365), score: 0.4 CLCNKAchloride channel Ka (ENSG00000186510), score: 0.51 CLDN10claudin 10 (ENSG00000134873), score: 0.44 CLDN15claudin 15 (ENSG00000106404), score: 0.47 CLDN16claudin 16 (ENSG00000113946), score: 0.54 CLDN19claudin 19 (ENSG00000164007), score: 0.7 CLDN24claudin 24 (ENSG00000185758), score: 0.47 CLDN8claudin 8 (ENSG00000156284), score: 0.55 CLRN3clarin 3 (ENSG00000180745), score: 0.4 CMAScytidine monophosphate N-acetylneuraminic acid synthetase (ENSG00000111726), score: -0.43 COCHcoagulation factor C homolog, cochlin (Limulus polyphemus) (ENSG00000100473), score: 0.6 COL19A1collagen, type XIX, alpha 1 (ENSG00000082293), score: 0.53 COL4A3collagen, type IV, alpha 3 (Goodpasture antigen) (ENSG00000169031), score: 0.42 COL4A6collagen, type IV, alpha 6 (ENSG00000197565), score: 0.46 CSN2casein beta (ENSG00000135222), score: 0.77 CTDSPLCTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (ENSG00000144677), score: 0.42 CTRCchymotrypsin C (caldecrin) (ENSG00000162438), score: 0.46 CUBNcubilin (intrinsic factor-cobalamin receptor) (ENSG00000107611), score: 0.58 CWH43cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) (ENSG00000109182), score: 0.46 CXCR3chemokine (C-X-C motif) receptor 3 (ENSG00000186810), score: 0.52 CYP24A1cytochrome P450, family 24, subfamily A, polypeptide 1 (ENSG00000019186), score: 0.57 CYP27B1cytochrome P450, family 27, subfamily B, polypeptide 1 (ENSG00000111012), score: 0.59 DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (ENSG00000153071), score: 0.44 DAZAP2DAZ associated protein 2 (ENSG00000183283), score: 0.43 DCBLD1discoidin, CUB and LCCL domain containing 1 (ENSG00000164465), score: -0.47 DDCdopa decarboxylase (aromatic L-amino acid decarboxylase) (ENSG00000132437), score: 0.42 DEFB4Bdefensin, beta 4B (ENSG00000171711), score: 0.94 DHDHdihydrodiol dehydrogenase (dimeric) (ENSG00000104808), score: 0.48 DMRT2doublesex and mab-3 related transcription factor 2 (ENSG00000173253), score: 0.43 DOCK8dedicator of cytokinesis 8 (ENSG00000107099), score: 0.52 DPEP1dipeptidase 1 (renal) (ENSG00000015413), score: 0.49 DPP4dipeptidyl-peptidase 4 (ENSG00000197635), score: 0.43 DUSP9dual specificity phosphatase 9 (ENSG00000130829), score: 0.48 EGFepidermal growth factor (ENSG00000138798), score: 0.49 EHFets homologous factor (ENSG00000135373), score: 0.4 ELF5E74-like factor 5 (ets domain transcription factor) (ENSG00000135374), score: 0.67 EPCAMepithelial cell adhesion molecule (ENSG00000119888), score: 0.44 ERMP1endoplasmic reticulum metallopeptidase 1 (ENSG00000099219), score: 0.42 ERP27endoplasmic reticulum protein 27 (ENSG00000139055), score: 0.42 ESM1endothelial cell-specific molecule 1 (ENSG00000164283), score: 0.51 ESRP1epithelial splicing regulatory protein 1 (ENSG00000104413), score: 0.55 ESRRBestrogen-related receptor beta (ENSG00000119715), score: 0.49 EVCEllis van Creveld syndrome (ENSG00000072840), score: 0.49 F2RL1coagulation factor II (thrombin) receptor-like 1 (ENSG00000164251), score: 0.48 FAM119Bfamily with sequence similarity 119, member B (ENSG00000123427), score: 0.44 FAM120AOSfamily with sequence similarity 120A opposite strand (ENSG00000188938), score: 0.41 FAM151Afamily with sequence similarity 151, member A (ENSG00000162391), score: 0.42 FAM174Afamily with sequence similarity 174, member A (ENSG00000174132), score: -0.42 FAM3Dfamily with sequence similarity 3, member D (ENSG00000198643), score: 0.4 FAM83Bfamily with sequence similarity 83, member B (ENSG00000168143), score: 0.45 FAM83Cfamily with sequence similarity 83, member C (ENSG00000125998), score: 0.53 FGFBP1fibroblast growth factor binding protein 1 (ENSG00000137440), score: 0.62 FKBP15FK506 binding protein 15, 133kDa (ENSG00000119321), score: 0.41 FLNBfilamin B, beta (ENSG00000136068), score: 0.4 FMO1flavin containing monooxygenase 1 (ENSG00000010932), score: 0.56 FMO4flavin containing monooxygenase 4 (ENSG00000076258), score: 0.41 FOLR1folate receptor 1 (adult) (ENSG00000110195), score: 0.53 FOXI1forkhead box I1 (ENSG00000168269), score: 0.55 FOXL1forkhead box L1 (ENSG00000176678), score: 0.5 FOXN1forkhead box N1 (ENSG00000109101), score: 0.67 FRAS1Fraser syndrome 1 (ENSG00000138759), score: 0.42 FRMD1FERM domain containing 1 (ENSG00000153303), score: 0.43 FUNDC1FUN14 domain containing 1 (ENSG00000069509), score: -0.47 FXYD2FXYD domain containing ion transport regulator 2 (ENSG00000137731), score: 0.43 FZD2frizzled homolog 2 (Drosophila) (ENSG00000180340), score: 0.42 GALgalanin prepropeptide (ENSG00000069482), score: 0.49 GALMgalactose mutarotase (aldose 1-epimerase) (ENSG00000143891), score: 0.4 GALNT11UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) (ENSG00000178234), score: 0.39 GALNT14UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) (ENSG00000158089), score: 0.5 GATA3GATA binding protein 3 (ENSG00000107485), score: 0.46 GCM1glial cells missing homolog 1 (Drosophila) (ENSG00000137270), score: 0.76 GCNT3glucosaminyl (N-acetyl) transferase 3, mucin type (ENSG00000140297), score: 0.52 GDPD3glycerophosphodiester phosphodiesterase domain containing 3 (ENSG00000102886), score: 0.57 GFRALGDNF family receptor alpha like (ENSG00000187871), score: 0.48 GGT6gamma-glutamyltransferase 6 (ENSG00000167741), score: 0.5 GIPC2GIPC PDZ domain containing family, member 2 (ENSG00000137960), score: 0.44 GKN2gastrokine 2 (ENSG00000183607), score: 0.5 GLYATglycine-N-acyltransferase (ENSG00000149124), score: 0.39 GNPDA1glucosamine-6-phosphate deaminase 1 (ENSG00000113552), score: 0.42 GNSglucosamine (N-acetyl)-6-sulfatase (ENSG00000135677), score: 0.44 GOSR2golgi SNAP receptor complex member 2 (ENSG00000108433), score: 0.4 GP2glycoprotein 2 (zymogen granule membrane) (ENSG00000169347), score: 0.65 GPR110G protein-coupled receptor 110 (ENSG00000153292), score: 0.47 GPR137BG protein-coupled receptor 137B (ENSG00000077585), score: 0.4 GPRC6AG protein-coupled receptor, family C, group 6, member A (ENSG00000173612), score: 0.63 GRB7growth factor receptor-bound protein 7 (ENSG00000141738), score: 0.51 GRHL2grainyhead-like 2 (Drosophila) (ENSG00000083307), score: 0.57 GSSglutathione synthetase (ENSG00000100983), score: 0.53 GYLTL1Bglycosyltransferase-like 1B (ENSG00000165905), score: 0.57 HAO2hydroxyacid oxidase 2 (long chain) (ENSG00000116882), score: 0.39 HAUS3HAUS augmin-like complex, subunit 3 (ENSG00000214367), score: -0.4 HECAheadcase homolog (Drosophila) (ENSG00000112406), score: -0.47 HMX2H6 family homeobox 2 (ENSG00000188816), score: 0.57 HNF1BHNF1 homeobox B (ENSG00000108753), score: 0.46 HOXA10homeobox A10 (ENSG00000153807), score: 0.49 HOXA11homeobox A11 (ENSG00000005073), score: 0.51 HOXA2homeobox A2 (ENSG00000105996), score: 0.66 HOXA3homeobox A3 (ENSG00000105997), score: 0.5 HOXA5homeobox A5 (ENSG00000106004), score: 0.49 HOXA7homeobox A7 (ENSG00000122592), score: 0.45 HOXA9homeobox A9 (ENSG00000078399), score: 0.49 HOXB5homeobox B5 (ENSG00000120075), score: 0.57 HOXB6homeobox B6 (ENSG00000108511), score: 0.52 HOXB7homeobox B7 (ENSG00000120087), score: 0.47 HOXC10homeobox C10 (ENSG00000180818), score: 0.56 HOXC5homeobox C5 (ENSG00000172789), score: 0.6 HOXC6homeobox C6 (ENSG00000197757), score: 0.46 HOXC8homeobox C8 (ENSG00000037965), score: 0.45 HOXC9homeobox C9 (ENSG00000180806), score: 0.47 HOXD10homeobox D10 (ENSG00000128710), score: 0.53 HOXD3homeobox D3 (ENSG00000128652), score: 0.44 HOXD4homeobox D4 (ENSG00000170166), score: 0.51 HOXD8homeobox D8 (ENSG00000175879), score: 0.42 HOXD9homeobox D9 (ENSG00000128709), score: 0.45 HRASLS2HRAS-like suppressor 2 (ENSG00000133328), score: 0.62 HSD11B2hydroxysteroid (11-beta) dehydrogenase 2 (ENSG00000176387), score: 0.56 HSF4heat shock transcription factor 4 (ENSG00000102878), score: -0.46 HTR1D5-hydroxytryptamine (serotonin) receptor 1D (ENSG00000179546), score: 0.63 IGFL3IGF-like family member 3 (ENSG00000188624), score: 0.54 IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (ENSG00000113302), score: 0.72 ILDR1immunoglobulin-like domain containing receptor 1 (ENSG00000145103), score: 0.46 INSRRinsulin receptor-related receptor (ENSG00000027644), score: 0.54 IRF5interferon regulatory factor 5 (ENSG00000128604), score: 0.4 IVNS1ABPinfluenza virus NS1A binding protein (ENSG00000116679), score: 0.43 KBTBD2kelch repeat and BTB (POZ) domain containing 2 (ENSG00000170852), score: -0.47 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.51 KCNJ16potassium inwardly-rectifying channel, subfamily J, member 16 (ENSG00000153822), score: 0.43 KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 1 (ENSG00000053918), score: 0.41 KCNS3potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 (ENSG00000170745), score: 0.44 KIAA1609KIAA1609 (ENSG00000140950), score: 0.51 KIAA1841KIAA1841 (ENSG00000162929), score: -0.4 KLklotho (ENSG00000133116), score: 0.53 KRT3keratin 3 (ENSG00000186442), score: 0.78 LAD1ladinin 1 (ENSG00000159166), score: 0.41 LAMB4laminin, beta 4 (ENSG00000091128), score: 0.87 LETM1leucine zipper-EF-hand containing transmembrane protein 1 (ENSG00000168924), score: 0.43 LGALS2lectin, galactoside-binding, soluble, 2 (ENSG00000100079), score: 0.51 LGMNlegumain (ENSG00000100600), score: 0.47 LMX1BLIM homeobox transcription factor 1, beta (ENSG00000136944), score: 0.46 LRRC19leucine rich repeat containing 19 (ENSG00000184434), score: 0.52 LRRC20leucine rich repeat containing 20 (ENSG00000172731), score: -0.41 LUC7LLUC7-like (S. cerevisiae) (ENSG00000007392), score: -0.4 MAP3K7mitogen-activated protein kinase kinase kinase 7 (ENSG00000135341), score: -0.44 MARCH6membrane-associated ring finger (C3HC4) 6 (ENSG00000145495), score: -0.41 MARVELD3MARVEL domain containing 3 (ENSG00000140832), score: 0.39 MAT2Amethionine adenosyltransferase II, alpha (ENSG00000168906), score: 0.46 MATN3matrilin 3 (ENSG00000132031), score: 0.54 MCCD1mitochondrial coiled-coil domain 1 (ENSG00000204511), score: 0.59 MCM10minichromosome maintenance complex component 10 (ENSG00000065328), score: 0.58 METTL1methyltransferase like 1 (ENSG00000037897), score: 0.42 MIOXmyo-inositol oxygenase (ENSG00000100253), score: 0.55 MMEmembrane metallo-endopeptidase (ENSG00000196549), score: 0.43 MMP13matrix metallopeptidase 13 (collagenase 3) (ENSG00000137745), score: 0.67 MOBKL2BMOB1, Mps One Binder kinase activator-like 2B (yeast) (ENSG00000120162), score: 0.42 MS4A10membrane-spanning 4-domains, subfamily A, member 10 (ENSG00000172689), score: 0.65 MS4A8Bmembrane-spanning 4-domains, subfamily A, member 8B (ENSG00000166959), score: 0.45 MSLNLmesothelin-like (ENSG00000162006), score: 0.69 MSRAmethionine sulfoxide reductase A (ENSG00000175806), score: 0.4 MTMR8myotubularin related protein 8 (ENSG00000102043), score: 0.65 MTNR1Amelatonin receptor 1A (ENSG00000168412), score: 0.63 MYO3Bmyosin IIIB (ENSG00000071909), score: 0.46 NARFnuclear prelamin A recognition factor (ENSG00000141562), score: -0.46 NCSTNnicastrin (ENSG00000162736), score: 0.41 NEK8NIMA (never in mitosis gene a)- related kinase 8 (ENSG00000160602), score: 0.4 NET1neuroepithelial cell transforming 1 (ENSG00000173848), score: 0.44 NEU1sialidase 1 (lysosomal sialidase) (ENSG00000204386), score: 0.39 NHSNance-Horan syndrome (congenital cataracts and dental anomalies) (ENSG00000188158), score: 0.44 NOX4NADPH oxidase 4 (ENSG00000086991), score: 0.52 NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin) (ENSG00000116218), score: 0.47 NPR3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) (ENSG00000113389), score: 0.46 NRG1neuregulin 1 (ENSG00000157168), score: 0.51 NTRK1neurotrophic tyrosine kinase, receptor, type 1 (ENSG00000198400), score: 0.44 OR10Q1olfactory receptor, family 10, subfamily Q, member 1 (ENSG00000180475), score: 0.72 OR51E1olfactory receptor, family 51, subfamily E, member 1 (ENSG00000180785), score: 0.41 OR51I2olfactory receptor, family 51, subfamily I, member 2 (ENSG00000187918), score: 0.45 OTOAotoancorin (ENSG00000155719), score: 0.47 OXGR1oxoglutarate (alpha-ketoglutarate) receptor 1 (ENSG00000165621), score: 0.58 OXNAD1oxidoreductase NAD-binding domain containing 1 (ENSG00000154814), score: 0.4 OXToxytocin, prepropeptide (ENSG00000101405), score: 0.56 PADI3peptidyl arginine deiminase, type III (ENSG00000142619), score: 0.51 PAIP2poly(A) binding protein interacting protein 2 (ENSG00000120727), score: -0.4 PAPLNpapilin, proteoglycan-like sulfated glycoprotein (ENSG00000100767), score: 0.57 PAPPA2pappalysin 2 (ENSG00000116183), score: 0.4 PAQR5progestin and adipoQ receptor family member V (ENSG00000137819), score: 0.49 PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans) (ENSG00000124171), score: 0.54 PARP1poly (ADP-ribose) polymerase 1 (ENSG00000143799), score: -0.48 PAX2paired box 2 (ENSG00000075891), score: 0.57 PAX8paired box 8 (ENSG00000125618), score: 0.49 PDCD5programmed cell death 5 (ENSG00000105185), score: -0.46 PDZK1IP1PDZK1 interacting protein 1 (ENSG00000162366), score: 0.46 PFDN2prefoldin subunit 2 (ENSG00000143256), score: -0.41 PGPEP1pyroglutamyl-peptidase I (ENSG00000130517), score: 0.43 PKHD1polycystic kidney and hepatic disease 1 (autosomal recessive) (ENSG00000170927), score: 0.56 PLA2G3phospholipase A2, group III (ENSG00000100078), score: 0.93 PLA2G4Fphospholipase A2, group IVF (ENSG00000168907), score: 0.45 PLAUplasminogen activator, urokinase (ENSG00000122861), score: 0.41 PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific) (ENSG00000197943), score: 0.43 PNLIPpancreatic lipase (ENSG00000175535), score: 0.4 PNPLA1patatin-like phospholipase domain containing 1 (ENSG00000180316), score: 0.75 PPM1Bprotein phosphatase, Mg2+/Mn2+ dependent, 1B (ENSG00000138032), score: -0.46 PPP1R14Dprotein phosphatase 1, regulatory (inhibitor) subunit 14D (ENSG00000166143), score: 0.4 PPYpancreatic polypeptide (ENSG00000108849), score: 0.55 PRLRprolactin receptor (ENSG00000113494), score: 0.56 PROM2prominin 2 (ENSG00000155066), score: 0.51 PRR13proline rich 13 (ENSG00000205352), score: 0.4 PRR15Lproline rich 15-like (ENSG00000167183), score: 0.45 PRSS8protease, serine, 8 (ENSG00000052344), score: 0.47 PSD3pleckstrin and Sec7 domain containing 3 (ENSG00000156011), score: -0.42 PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 (ENSG00000115233), score: -0.41 PTH1Rparathyroid hormone 1 receptor (ENSG00000160801), score: 0.41 PTPLAD2protein tyrosine phosphatase-like A domain containing 2 (ENSG00000188921), score: 0.57 RAB19RAB19, member RAS oncogene family (ENSG00000146955), score: 0.61 RAB25RAB25, member RAS oncogene family (ENSG00000132698), score: 0.49 RAB34RAB34, member RAS oncogene family (ENSG00000109113), score: 0.42 RAB38RAB38, member RAS oncogene family (ENSG00000123892), score: 0.46 RAB7L1RAB7, member RAS oncogene family-like 1 (ENSG00000117280), score: 0.5 REG3Aregenerating islet-derived 3 alpha (ENSG00000172016), score: 0.47 RELTRELT tumor necrosis factor receptor (ENSG00000054967), score: -0.42 RENrenin (ENSG00000143839), score: 0.62 RHBGRh family, B glycoprotein (gene/pseudogene) (ENSG00000132677), score: 0.48 RHCGRh family, C glycoprotein (ENSG00000140519), score: 0.46 RIPPLY1ripply1 homolog (zebrafish) (ENSG00000147223), score: 0.53 SCAMP2secretory carrier membrane protein 2 (ENSG00000140497), score: 0.41 SCINscinderin (ENSG00000006747), score: 0.43 SCNN1Asodium channel, nonvoltage-gated 1 alpha (ENSG00000111319), score: 0.47 SCNN1Bsodium channel, nonvoltage-gated 1, beta (ENSG00000168447), score: 0.51 SCNN1Gsodium channel, nonvoltage-gated 1, gamma (ENSG00000166828), score: 0.48 SCTRsecretin receptor (ENSG00000080293), score: 0.49 SFNstratifin (ENSG00000175793), score: 0.48 SFXN2sideroflexin 2 (ENSG00000156398), score: 0.49 SHISA2shisa homolog 2 (Xenopus laevis) (ENSG00000180730), score: 0.43 SIM1single-minded homolog 1 (Drosophila) (ENSG00000112246), score: 0.53 SIM2single-minded homolog 2 (Drosophila) (ENSG00000159263), score: 0.46 SLC10A2solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (ENSG00000125255), score: 0.49 SLC12A1solute carrier family 12 (sodium/potassium/chloride transporters), member 1 (ENSG00000074803), score: 0.53 SLC12A3solute carrier family 12 (sodium/chloride transporters), member 3 (ENSG00000070915), score: 0.56 SLC12A6solute carrier family 12 (potassium/chloride transporters), member 6 (ENSG00000140199), score: 0.49 SLC13A1solute carrier family 13 (sodium/sulfate symporters), member 1 (ENSG00000081800), score: 0.44 SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (ENSG00000158296), score: 0.46 SLC15A2solute carrier family 15 (H+/peptide transporter), member 2 (ENSG00000163406), score: 0.41 SLC15A5solute carrier family 15, member 5 (ENSG00000188991), score: 0.86 SLC16A11solute carrier family 16, member 11 (monocarboxylic acid transporter 11) (ENSG00000174326), score: 0.46 SLC16A12solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (ENSG00000152779), score: 0.43 SLC16A4solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (ENSG00000168679), score: 0.5 SLC16A9solute carrier family 16, member 9 (monocarboxylic acid transporter 9) (ENSG00000165449), score: 0.57 SLC17A3solute carrier family 17 (sodium phosphate), member 3 (ENSG00000124564), score: 0.44 SLC18A1solute carrier family 18 (vesicular monoamine), member 1 (ENSG00000036565), score: 0.56 SLC22A11solute carrier family 22 (organic anion/urate transporter), member 11 (ENSG00000168065), score: 0.54 SLC22A12solute carrier family 22 (organic anion/urate transporter), member 12 (ENSG00000197891), score: 0.53 SLC22A13solute carrier family 22 (organic anion transporter), member 13 (ENSG00000172940), score: 0.6 SLC22A2solute carrier family 22 (organic cation transporter), member 2 (ENSG00000112499), score: 0.54 SLC22A4solute carrier family 22 (organic cation/ergothioneine transporter), member 4 (ENSG00000197208), score: 0.56 SLC22A5solute carrier family 22 (organic cation/carnitine transporter), member 5 (ENSG00000197375), score: 0.48 SLC22A6solute carrier family 22 (organic anion transporter), member 6 (ENSG00000197901), score: 0.5 SLC22A8solute carrier family 22 (organic anion transporter), member 8 (ENSG00000149452), score: 0.51 SLC23A1solute carrier family 23 (nucleobase transporters), member 1 (ENSG00000170482), score: 0.44 SLC23A3solute carrier family 23 (nucleobase transporters), member 3 (ENSG00000213901), score: 0.57 SLC25A45solute carrier family 25, member 45 (ENSG00000162241), score: 0.5 SLC26A7solute carrier family 26, member 7 (ENSG00000147606), score: 0.44 SLC30A2solute carrier family 30 (zinc transporter), member 2 (ENSG00000158014), score: 0.42 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 0.52 SLC34A3solute carrier family 34 (sodium phosphate), member 3 (ENSG00000198569), score: 0.48 SLC35F2solute carrier family 35, member F2 (ENSG00000110660), score: 0.42 SLC37A4solute carrier family 37 (glucose-6-phosphate transporter), member 4 (ENSG00000137700), score: 0.4 SLC38A8solute carrier family 38, member 8 (ENSG00000166558), score: 0.49 SLC39A5solute carrier family 39 (metal ion transporter), member 5 (ENSG00000139540), score: 0.41 SLC3A2solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 (ENSG00000168003), score: 0.42 SLC44A3solute carrier family 44, member 3 (ENSG00000143036), score: 0.48 SLC44A4solute carrier family 44, member 4 (ENSG00000204385), score: 0.48 SLC47A1solute carrier family 47, member 1 (ENSG00000142494), score: 0.44 SLC47A2solute carrier family 47, member 2 (ENSG00000180638), score: 0.47 SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (ENSG00000004939), score: 0.52 SLC4A9solute carrier family 4, sodium bicarbonate cotransporter, member 9 (ENSG00000113073), score: 0.49 SLC5A10solute carrier family 5 (sodium/glucose cotransporter), member 10 (ENSG00000154025), score: 0.48 SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12 (ENSG00000148942), score: 0.49 SLC5A8solute carrier family 5 (iodide transporter), member 8 (ENSG00000139357), score: 0.65 SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19 (ENSG00000174358), score: 0.61 SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (ENSG00000142319), score: 0.42 SLC6A4solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (ENSG00000108576), score: 0.57 SLC7A10solute carrier family 7, (neutral amino acid transporter, y+ system) member 10 (ENSG00000130876), score: 0.47 SLC7A13solute carrier family 7, (cationic amino acid transporter, y+ system) member 13 (ENSG00000164893), score: 0.6 SLC7A7solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 (ENSG00000155465), score: 0.41 SLC7A8solute carrier family 7 (amino acid transporter, L-type), member 8 (ENSG00000092068), score: 0.5 SLC7A9solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 (ENSG00000021488), score: 0.48 SLC9A3solute carrier family 9 (sodium/hydrogen exchanger), member 3 (ENSG00000066230), score: 0.43 SLC9A4solute carrier family 9 (sodium/hydrogen exchanger), member 4 (ENSG00000180251), score: 0.61 SLCO4C1solute carrier organic anion transporter family, member 4C1 (ENSG00000173930), score: 0.39 SMTNL2smoothelin-like 2 (ENSG00000188176), score: 0.42 SNX29sorting nexin 29 (ENSG00000048471), score: 0.49 SOX14SRY (sex determining region Y)-box 14 (ENSG00000168875), score: 0.65 SPNS3spinster homolog 3 (Drosophila) (ENSG00000182557), score: 0.39 SPTLC3serine palmitoyltransferase, long chain base subunit 3 (ENSG00000172296), score: 0.43 STARD8StAR-related lipid transfer (START) domain containing 8 (ENSG00000130052), score: 0.46 STK32Bserine/threonine kinase 32B (ENSG00000152953), score: 0.41 STK38serine/threonine kinase 38 (ENSG00000112079), score: 0.46 STRA6stimulated by retinoic acid gene 6 homolog (mouse) (ENSG00000137868), score: 0.57 SULT1C2sulfotransferase family, cytosolic, 1C, member 2 (ENSG00000198203), score: 0.46 SUSD2sushi domain containing 2 (ENSG00000099994), score: 0.52 TAAR2trace amine associated receptor 2 (ENSG00000146378), score: 0.57 TACSTD2tumor-associated calcium signal transducer 2 (ENSG00000184292), score: 0.46 TARSL2threonyl-tRNA synthetase-like 2 (ENSG00000185418), score: -0.41 TBX19T-box 19 (ENSG00000143178), score: 0.47 TCL1BT-cell leukemia/lymphoma 1B (ENSG00000213231), score: 0.47 TCN2transcobalamin II (ENSG00000185339), score: 0.52 TDGF1teratocarcinoma-derived growth factor 1 (ENSG00000241186), score: 0.44 TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (ENSG00000137203), score: 0.44 TFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta) (ENSG00000008196), score: 0.44 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.52 TFECtranscription factor EC (ENSG00000105967), score: 0.59 TINAGtubulointerstitial nephritis antigen (ENSG00000137251), score: 0.53 TM7SF3transmembrane 7 superfamily member 3 (ENSG00000064115), score: 0.4 TMED4transmembrane emp24 protein transport domain containing 4 (ENSG00000158604), score: 0.47 TMEM106Ctransmembrane protein 106C (ENSG00000134291), score: 0.44 TMEM139transmembrane protein 139 (ENSG00000178826), score: 0.42 TMEM171transmembrane protein 171 (ENSG00000157111), score: 0.49 TMEM174transmembrane protein 174 (ENSG00000164325), score: 0.49 TMEM179Btransmembrane protein 179B (ENSG00000185475), score: 0.44 TMEM27transmembrane protein 27 (ENSG00000147003), score: 0.48 TMEM61transmembrane protein 61 (ENSG00000143001), score: 0.4 TMEM72transmembrane protein 72 (ENSG00000187783), score: 0.59 TMEM86Atransmembrane protein 86A (ENSG00000151117), score: 0.45 TMIGD1transmembrane and immunoglobulin domain containing 1 (ENSG00000182271), score: 0.72 TMPRSS13transmembrane protease, serine 13 (ENSG00000137747), score: 0.79 TMPRSS2transmembrane protease, serine 2 (ENSG00000184012), score: 0.44 TNFSF15tumor necrosis factor (ligand) superfamily, member 15 (ENSG00000181634), score: 0.62 TPCN1two pore segment channel 1 (ENSG00000186815), score: 0.43 TRAF3IP2TRAF3 interacting protein 2 (ENSG00000056972), score: 0.41 TRPM6transient receptor potential cation channel, subfamily M, member 6 (ENSG00000119121), score: 0.5 TRPV4transient receptor potential cation channel, subfamily V, member 4 (ENSG00000111199), score: 0.51 TSPAN1tetraspanin 1 (ENSG00000117472), score: 0.42 TTC22tetratricopeptide repeat domain 22 (ENSG00000006555), score: 0.46 TUBAL3tubulin, alpha-like 3 (ENSG00000178462), score: 0.6 TULP3tubby like protein 3 (ENSG00000078246), score: 0.48 UBE2Kubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) (ENSG00000078140), score: -0.42 UCMAupper zone of growth plate and cartilage matrix associated (ENSG00000165623), score: 0.53 UCN3urocortin 3 (stresscopin) (ENSG00000178473), score: 1 UMODuromodulin (ENSG00000169344), score: 0.53 UPK1Buroplakin 1B (ENSG00000114638), score: 0.47 UPK2uroplakin 2 (ENSG00000110375), score: 0.95 USH1CUsher syndrome 1C (autosomal recessive, severe) (ENSG00000006611), score: 0.43 VAV3vav 3 guanine nucleotide exchange factor (ENSG00000134215), score: 0.42 VDRvitamin D (1,25- dihydroxyvitamin D3) receptor (ENSG00000111424), score: 0.54 VGLL1vestigial like 1 (Drosophila) (ENSG00000102243), score: 0.6 VIL1villin 1 (ENSG00000127831), score: 0.47 WARS2tryptophanyl tRNA synthetase 2, mitochondrial (ENSG00000116874), score: 0.42 WFDC2WAP four-disulfide core domain 2 (ENSG00000101443), score: 0.4 WNK4WNK lysine deficient protein kinase 4 (ENSG00000126562), score: 0.48 WNT9Bwingless-type MMTV integration site family, member 9B (ENSG00000158955), score: 0.54 XPCxeroderma pigmentosum, complementation group C (ENSG00000154767), score: 0.5 XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (ENSG00000122121), score: 0.55 ZBTB16zinc finger and BTB domain containing 16 (ENSG00000109906), score: -0.41 ZFATzinc finger and AT hook domain containing (ENSG00000066827), score: 0.4 ZNF16zinc finger protein 16 (ENSG00000170631), score: 0.4 ZNF618zinc finger protein 618 (ENSG00000157657), score: 0.49 ZSCAN2zinc finger and SCAN domain containing 2 (ENSG00000176371), score: 0.46

Non-Entrez genes

ENSG00000170631Unknown, score: 0.54 ENSG00000163814Unknown, score: 0.47 ENSG00000137960Unknown, score: 0.53

Id	species	tissue	sex	individual
hsa_kd_m1_ca1	hsa	kd	m	1
mml_kd_f_ca1	mml	kd	f	_
mml_kd_m_ca1	mml	kd	m	_