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immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

antigen processing and presentation of peptide antigen via MHC class I

The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.

antigen processing and presentation of endogenous peptide antigen

The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell.

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

The process by which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

antigen processing and presentation

The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

antigen processing and presentation of endogenous antigen

The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex.

antigen processing and presentation of endogenous peptide antigen via MHC class I

The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.

intracellular transport

The directed movement of substances within a cell.

cytosol to ER transport

The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell.

antigen processing and presentation of peptide antigen

The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

all

NA

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

intracellular transport

The directed movement of substances within a cell.

antigen processing and presentation of endogenous peptide antigen

The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell.

antigen processing and presentation of endogenous peptide antigen via MHC class I

The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

lytic vacuole

A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

MHC class II protein complex

A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.

lysosome

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

lysosomal membrane

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

endosome

A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

endosome membrane

The lipid bilayer surrounding an endosome.

endomembrane system

A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

integral to endoplasmic reticulum membrane

Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

organelle membrane

The lipid bilayer surrounding an organelle.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to endoplasmic reticulum membrane

Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to organelle membrane

Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

integral to organelle membrane

Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

MHC class I peptide loading complex

A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.

TAP complex

A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

endosomal part

Any constituent part of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intrinsic to organelle membrane

Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

TAP complex

A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum.

intrinsic to endoplasmic reticulum membrane

Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

intrinsic to endoplasmic reticulum membrane

Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

MHC class I peptide loading complex

A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.

TAP complex

A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

endosome membrane

The lipid bilayer surrounding an endosome.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

endosome

A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

endosomal part

Any constituent part of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

intrinsic to organelle membrane

Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

endosomal part

Any constituent part of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

integral to endoplasmic reticulum membrane

Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

integral to organelle membrane

Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

MHC class I peptide loading complex

A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.

lysosomal membrane

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

ATPase activity, coupled

Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

ATPase activity, coupled to transmembrane movement of substances

Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane.

nucleoside-triphosphatase activity

Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transmembrane receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

MHC class II receptor activity

Combining with an MHC class II protein complex to initiate a change in cellular activity.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction.

peptide transporter activity

Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells.

primary active transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources.

P-P-bond-hydrolysis-driven transmembrane transporter activity

Primary active transport of a solute across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source.

peptide antigen-transporting ATPase activity

Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate.

peptide-transporting ATPase activity

Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria.

pyrophosphatase activity

Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

hydrolase activity, acting on acid anhydrides

Catalysis of the hydrolysis of any acid anhydride.

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane.

active transmembrane transporter activity

Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ATPase activity, coupled to movement of substances

Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance.

TAP binding

Interacting selectively and non-covalently with TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2.

TAP1 binding

Interacting selectively and non-covalently with the TAP1 subunit of TAP (transporter associated with antigen processing) protein.

TAP2 binding

Interacting selectively and non-covalently with the TAP2 subunit of TAP (transporter associated with antigen processing) protein.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

NA

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane.

peptide-transporting ATPase activity

Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria.

ATPase activity, coupled to transmembrane movement of substances

Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane.

ATPase activity, coupled to transmembrane movement of substances

Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0019882	1.666e-10	0.3163	10 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, PSMB9, TAP1, TAP2, TAPBP	37	antigen processing and presentation
GO:0002504	3.492e-08	0.09404	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	11	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002483	7.674e-04	0.0513	3 TAP1, TAP2, TAPBP	6	antigen processing and presentation of endogenous peptide antigen
GO:0019885	7.674e-04	0.0513	3 TAP1, TAP2, TAPBP	6	antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0019883	1.820e-03	0.0684	3 TAP1, TAP2, TAPBP	8	antigen processing and presentation of endogenous antigen
GO:0046967	3.506e-03	0.0171	2 TAP1, TAP2	2	cytosol to ER transport
GO:0002474	4.400e-03	0.09404	3 TAP1, TAP2, TAPBP	11	antigen processing and presentation of peptide antigen via MHC class I
GO:0048002	1.331e-02	0.1453	3 TAP1, TAP2, TAPBP	17	antigen processing and presentation of peptide antigen
GO:0019060	1.477e-02	0.0342	2 TAP1, TAP2	4	intracellular transport of viral proteins in host cell
GO:0030581	1.477e-02	0.0342	2 TAP1, TAP2	4	symbiont intracellular protein transport in host
GO:0046719	1.477e-02	0.0342	2 TAP1, TAP2	4	regulation of viral protein levels in host cell
GO:0051708	1.477e-02	0.0342	2 TAP1, TAP2	4	intracellular protein transport in other organism involved in symbiotic interaction
GO:0009059	4.897e-02	21.59	34 AGER, ALAS2, ATRIP, ATXN1, AZU1, B3GALT4, CEBPE, DAXX, EIF2B5, FGF2, GFM2, GHRH, HARS2, HTATIP2, MED6, MEF2B, MRPL36, MRPS30, POLR2F, POLR2I, RFX8, RING1, RPL37, RXRB, SAP18, SAP30BP, SCYL1, SRFBP1, TCF19, ZBTB22, ZNF232, ZNF394, ZNF589, ZNF629	2525	macromolecule biosynthetic process

Id	Pvalue	ExpCount	Count	Size	Term
GO:0042613	7.634e-10	0.06926	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	8	MHC class II protein complex
GO:0042611	5.548e-08	0.1212	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	14	MHC protein complex
GO:0042825	2.075e-05	0.02597	3 TAP1, TAP2, TAPBP	3	TAP complex
GO:0042824	7.108e-05	0.03463	3 TAP1, TAP2, TAPBP	4	MHC class I peptide loading complex
GO:0005765	9.384e-04	0.6493	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	75	lysosomal membrane
GO:0000323	3.463e-03	1.61	8 AZU1, CTSK, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	186	lytic vacuole
GO:0005764	3.463e-03	1.61	8 AZU1, CTSK, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	186	lysosome
GO:0005774	4.097e-03	0.8831	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	102	vacuolar membrane
GO:0044437	5.350e-03	0.935	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	108	vacuolar part
GO:0010008	6.605e-03	1.368	7 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, VPS52	158	endosome membrane
GO:0044440	6.605e-03	1.368	7 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, VPS52	158	endosomal part
GO:0005773	9.559e-03	1.922	8 AZU1, CTSK, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	222	vacuole
GO:0032991	2.043e-02	19.32	32 API5, ATXN1, BEST1, CENPN, CENPO, DCAF17, EIF2B5, EXOSC3, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, MED6, MEF2B, MRPL36, MRPS30, NDUFB9, PFDN6, POLR2F, POLR2I, PSMB8, PSMB9, RING1, RPL37, SAP18, SCYL1, TAP1, TAP2, TAPBP, UTP14A	2232	macromolecular complex
GO:0005665	2.911e-02	0.07792	2 POLR2F, POLR2I	9	DNA-directed RNA polymerase II, core complex

Id	Pvalue	ExpCount	Count	Size	Term
GO:0046977	3.941e-05	0.02467	3 TAP1, TAP2, TAPBP	3	TAP binding
GO:0046978	3.941e-05	0.02467	3 TAP1, TAP2, TAPBP	3	TAP1 binding
GO:0032395	3.014e-04	0.04112	3 HLA-DOB, HLA-DPA1, HLA-DRA	5	MHC class II receptor activity
GO:0015197	2.493e-03	0.08224	3 TAP1, TAP2, TAPBP	10	peptide transporter activity
GO:0015433	2.659e-03	0.01645	2 TAP2, TAPBP	2	peptide antigen-transporting ATPase activity
GO:0046979	2.659e-03	0.01645	2 TAP1, TAPBP	2	TAP2 binding
GO:0015440	6.554e-03	0.02467	2 TAP2, TAPBP	3	peptide-transporting ATPase activity
GO:0003899	4.312e-02	0.2632	3 POLR2F, POLR2I, ZNRD1	32	DNA-directed RNA polymerase activity
GO:0034062	4.312e-02	0.2632	3 POLR2F, POLR2I, ZNRD1	32	RNA polymerase activity
GO:0042605	4.416e-02	0.07401	2 TAP1, TAPBP	9	peptide antigen binding

Id	Pvalue	ExpCount	Count	Size	Term
04612	3.244e-09	0.3556	9 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, TAP1, TAP2, TAPBP	44	Antigen processing and presentation
05310	6.808e-07	0.1697	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	21	Asthma
05330	1.581e-06	0.194	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	24	Allograft rejection
05332	1.581e-06	0.194	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	24	Graft-versus-host disease
04940	3.232e-06	0.2182	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	27	Type I diabetes mellitus
05320	3.951e-06	0.2263	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	28	Autoimmune thyroid disease
04672	1.975e-05	0.299	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	37	Intestinal immune network for IgA production
05416	2.294e-05	0.3071	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	38	Viral myocarditis
04145	2.584e-05	0.7516	8 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, TAP1, TAP2	93	Phagosome
05140	1.149e-04	0.4121	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	51	Leishmaniasis
05322	1.262e-04	0.4202	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	52	Systemic lupus erythematosus
04514	3.835e-03	0.8243	6 HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA	102	Cell adhesion molecules (CAMs)
03020	1.000e-02	0.1535	3 POLR2F, POLR2I, ZNRD1	19	RNA polymerase

No enriched terms

Id	Pvalue	ExpCount	Count	Size
6	2.080e-12	5.871	32 AGER, ATXN1, B3GALT4, BRD2, C6orf126, CCHCR1, DAXX, HLA-DMA, HLA-DMB, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DRA, HSD17B8, PFDN6, PRL, PSMB8, PSMB9, RGL2, RING1, RXRB, SLC39A7, TAP1, TAP2, TAPBP, TCF19, TRIM26, VNN2, VPS52, WDR46, ZBTB22, ZNRD1	721

Entrez genes

ABHD12Babhydrolase domain containing 12B (ENSG00000131969), score: 0.6 ACCN4amiloride-sensitive cation channel 4, pituitary (ENSG00000072182), score: 0.61 ACSBG1acyl-CoA synthetase bubblegum family member 1 (ENSG00000103740), score: -0.63 ADCK2aarF domain containing kinase 2 (ENSG00000133597), score: 0.95 AGERadvanced glycosylation end product-specific receptor (ENSG00000204305), score: 0.58 ALAS2aminolevulinate, delta-, synthase 2 (ENSG00000158578), score: 0.64 API5apoptosis inhibitor 5 (ENSG00000166181), score: -0.95 ATRIPATR interacting protein (ENSG00000164053), score: 0.85 ATXN1ataxin 1 (ENSG00000124788), score: -0.6 AVILadvillin (ENSG00000135407), score: 0.79 AZU1azurocidin 1 (ENSG00000172232), score: 0.59 B3GALT4UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 (ENSG00000235863), score: -0.69 BEST1bestrophin 1 (ENSG00000167995), score: -0.68 BRD2bromodomain containing 2 (ENSG00000204256), score: -1 C16orf61chromosome 16 open reading frame 61 (ENSG00000103121), score: 0.72 C16orf79chromosome 16 open reading frame 79 (ENSG00000182685), score: -0.64 C1orf56chromosome 1 open reading frame 56 (ENSG00000143443), score: -0.61 C2orf66chromosome 2 open reading frame 66 (ENSG00000187944), score: 0.63 C3orf75chromosome 3 open reading frame 75 (ENSG00000163832), score: -0.77 C5orf13chromosome 5 open reading frame 13 (ENSG00000134986), score: -0.76 C6orf126chromosome 6 open reading frame 126 (ENSG00000196748), score: 0.69 CA1carbonic anhydrase I (ENSG00000133742), score: 0.67 CCDC152coiled-coil domain containing 152 (ENSG00000198865), score: -0.66 CCHCR1coiled-coil alpha-helical rod protein 1 (ENSG00000204536), score: -0.71 CD101CD101 molecule (ENSG00000134256), score: 0.63 CEBPECCAAT/enhancer binding protein (C/EBP), epsilon (ENSG00000092067), score: 0.69 CENPNcentromere protein N (ENSG00000166451), score: -0.65 CENPOcentromere protein O (ENSG00000138092), score: -0.62 CLEC5AC-type lectin domain family 5, member A (ENSG00000090269), score: 0.78 CTSKcathepsin K (ENSG00000143387), score: 0.57 DAXXdeath-domain associated protein (ENSG00000204209), score: -0.96 DCAF17DDB1 and CUL4 associated factor 17 (ENSG00000115827), score: -0.62 DNAL1dynein, axonemal, light chain 1 (ENSG00000119661), score: 0.71 EIF2B5eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa (ENSG00000145191), score: 0.64 EMR3egf-like module containing, mucin-like, hormone receptor-like 3 (ENSG00000131355), score: 0.81 EXOSC3exosome component 3 (ENSG00000107371), score: 0.59 FAM166Afamily with sequence similarity 166, member A (ENSG00000188163), score: -0.9 FAM173Bfamily with sequence similarity 173, member B (ENSG00000150756), score: 0.57 FGF2fibroblast growth factor 2 (basic) (ENSG00000138685), score: -0.73 FRMD8FERM domain containing 8 (ENSG00000126391), score: -0.76 GFM2G elongation factor, mitochondrial 2 (ENSG00000164347), score: 0.61 GHRHgrowth hormone releasing hormone (ENSG00000118702), score: 0.88 GLTPglycolipid transfer protein (ENSG00000139433), score: -0.68 GPR107G protein-coupled receptor 107 (ENSG00000148358), score: -0.62 HARS2histidyl-tRNA synthetase 2, mitochondrial (putative) (ENSG00000112855), score: 0.62 HLA-DMAmajor histocompatibility complex, class II, DM alpha (ENSG00000204257), score: -0.68 HLA-DMBmajor histocompatibility complex, class II, DM beta (ENSG00000242574), score: -0.62 HLA-DOBmajor histocompatibility complex, class II, DO beta (ENSG00000204267), score: -0.82 HLA-DPA1major histocompatibility complex, class II, DP alpha 1 (ENSG00000231389), score: -0.75 HLA-DPB1major histocompatibility complex, class II, DP beta 1 (ENSG00000223865), score: -0.77 HLA-DRAmajor histocompatibility complex, class II, DR alpha (ENSG00000204287), score: -0.78 HSD17B8hydroxysteroid (17-beta) dehydrogenase 8 (ENSG00000204228), score: -0.75 HTATIP2HIV-1 Tat interactive protein 2, 30kDa (ENSG00000109854), score: -0.62 IBSPintegrin-binding sialoprotein (ENSG00000029559), score: 0.58 LOXL3lysyl oxidase-like 3 (ENSG00000115318), score: -0.78 LYG2lysozyme G-like 2 (ENSG00000185674), score: 0.82 MED6mediator complex subunit 6 (ENSG00000133997), score: -0.6 MEF2Bmyocyte enhancer factor 2B (ENSG00000064489), score: -0.69 MESDC2mesoderm development candidate 2 (ENSG00000117899), score: 0.59 MINAMYC induced nuclear antigen (ENSG00000170854), score: 0.57 MLANAmelan-A (ENSG00000120215), score: 0.65 MRPL36mitochondrial ribosomal protein L36 (ENSG00000171421), score: -0.7 MRPS30mitochondrial ribosomal protein S30 (ENSG00000112996), score: -0.59 MYOZ3myozenin 3 (ENSG00000164591), score: 0.64 NDUFB9NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa (ENSG00000147684), score: -0.61 PFDN6prefoldin subunit 6 (ENSG00000204220), score: -0.99 PHF23PHD finger protein 23 (ENSG00000040633), score: 0.96 POLR2Fpolymerase (RNA) II (DNA directed) polypeptide F (ENSG00000100142), score: -0.7 POLR2Ipolymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa (ENSG00000105258), score: -0.63 PRLprolactin (ENSG00000172179), score: 0.67 PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (ENSG00000204264), score: -0.65 PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) (ENSG00000240065), score: -0.7 PTCD3Pentatricopeptide repeat domain 3 (ENSG00000132300), score: 0.66 RAB40ARAB40A, member RAS oncogene family (ENSG00000172476), score: 0.58 RFX8regulatory factor X, 8 (ENSG00000196460), score: 0.69 RGL2ral guanine nucleotide dissociation stimulator-like 2 (ENSG00000237441), score: -0.97 RING1ring finger protein 1 (ENSG00000204227), score: -1 RNMTRNA (guanine-7-) methyltransferase (ENSG00000101654), score: -0.69 RPL37ribosomal protein L37 (ENSG00000145592), score: -0.85 RXRBretinoid X receptor, beta (ENSG00000204231), score: -0.99 SAP18Sin3A-associated protein, 18kDa (ENSG00000150459), score: 0.59 SAP30BPSAP30 binding protein (ENSG00000161526), score: 0.58 SCYL1SCY1-like 1 (S. cerevisiae) (ENSG00000142186), score: 0.96 SLC39A7solute carrier family 39 (zinc transporter), member 7 (ENSG00000112473), score: -0.97 SRFBP1serum response factor binding protein 1 (ENSG00000151304), score: 0.6 SUPV3L1suppressor of var1, 3-like 1 (S. cerevisiae) (ENSG00000156502), score: 0.6 TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) (ENSG00000168394), score: -0.77 TAPBPTAP binding protein (tapasin) (ENSG00000231925), score: -0.94 TCF19transcription factor 19 (ENSG00000137310), score: -0.6 TCTEX1D1Tctex1 domain containing 1 (ENSG00000152760), score: 0.61 TFF1trefoil factor 1 (ENSG00000160182), score: 0.58 THUMPD3THUMP domain containing 3 (ENSG00000134077), score: -0.83 TMEM131transmembrane protein 131 (ENSG00000075568), score: -0.62 TMEM80transmembrane protein 80 (ENSG00000177042), score: -0.63 TRIM26tripartite motif-containing 26 (ENSG00000234127), score: -0.95 TRIT1tRNA isopentenyltransferase 1 (ENSG00000043514), score: 0.61 UTP14AUTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) (ENSG00000156697), score: 0.57 VNN2vanin 2 (ENSG00000112303), score: 0.58 VPS52vacuolar protein sorting 52 homolog (S. cerevisiae) (ENSG00000223501), score: -1 WDR46WD repeat domain 46 (ENSG00000227057), score: -0.98 ZBTB22zinc finger and BTB domain containing 22 (ENSG00000236104), score: -0.94 ZNF232zinc finger protein 232 (ENSG00000167840), score: 0.62 ZNF394zinc finger protein 394 (ENSG00000160908), score: 0.58 ZNF589zinc finger protein 589 (ENSG00000164048), score: -0.78 ZNF629zinc finger protein 629 (ENSG00000102870), score: -0.61 ZNRD1zinc ribbon domain containing 1 (ENSG00000066379), score: -0.9

Non-Entrez genes

Unknown, score:

Id	species	tissue	sex	individual
ppy_br_m_ca1	ppy	br	m	_
ppy_cb_f_ca1	ppy	cb	f	_
ppy_br_f_ca1	ppy	br	f	_
ppy_kd_m_ca1	ppy	kd	m	_
ppy_ht_m_ca1	ppy	ht	m	_
ppy_lv_m_ca1	ppy	lv	m	_
ppy_ht_f_ca1	ppy	ht	f	_
ppy_kd_f_ca1	ppy	kd	f	_
ppy_lv_f_ca1	ppy	lv	f	_