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cell morphogenesis

The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form.

cell morphogenesis involved in differentiation

The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

signal transduction

The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

nucleoside phosphate metabolic process

The chemical reactions and pathways involving any phosphorylated nucleoside.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

potassium ion transport

The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

cell surface receptor linked signaling pathway

Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.

G-protein coupled receptor protein signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.

G-protein signaling, coupled to cyclic nucleotide second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.

G-protein signaling, coupled to cAMP nucleotide second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP.

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate.

activation of phospholipase C activity

The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.

serotonin receptor signaling pathway

The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.

cell-cell signaling

Any process that mediates the transfer of information from one cell to another.

synaptic transmission

The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

nerve-nerve synaptic transmission

The process of communication from a neuron to another neuron across a synapse.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

nervous system development

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

neurological system process

A organ system process carried out by any of the organs or tissues of neurological system.

axonogenesis

Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells.

central nervous system development

The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.

brain development

The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).

behavior

The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

learning or memory

The acquisition and processing of information and/or the storage and retrieval of this information over time.

memory

The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).

feeding behavior

Behavior associated with the intake of food.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

nucleotide metabolic process

The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).

nucleoside monophosphate metabolic process

The chemical reactions and pathways involving a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety.

nucleoside monophosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety.

nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).

cyclic nucleotide metabolic process

The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.

cyclic nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of phospholipase activity

Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.

positive regulation of phospholipase activity

Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.

positive regulation of phospholipase C activity

Any process that increases the rate of phospholipase C activity.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

cellular component organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

second-messenger-mediated signaling

A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell.

cAMP-mediated signaling

A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.

cyclic-nucleotide-mediated signaling

A series of molecular signals in which a cell uses a cyclic nucleotide to convert an extracellular signal into a response.

phosphoinositide-mediated signaling

A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response.

cerebral cortex GABAergic interneuron differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex.

cerebral cortex neuron differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.

central nervous system neuron differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.

neurogenesis

Generation of cells within the nervous system.

signaling pathway

The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.

intracellular signaling pathway

The series of molecular events whereby information is sent from one location to another within a cell.

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

signaling

The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.

signal transmission

The process whereby a signal is released and/or conveyed from one location to another.

cell projection organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

neuron differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a neuron.

forebrain development

The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).

neuron projection development

The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

cellular component morphogenesis

The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.

cell part morphogenesis

The process by which the anatomical structures of a cell part are generated and organized. Morphogenesis pertains to the creation of form.

nucleobase, nucleoside and nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides and nucleotides.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.

synaptic transmission, glutamatergic

The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.

intracellular signal transduction

The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

positive regulation of molecular function

Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular nitrogen compound biosynthetic process

The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.

small molecule biosynthetic process

The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

neuron development

The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

cell morphogenesis involved in neuron differentiation

The process by which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.

generation of neurons

The process by which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

neuron projection morphogenesis

The process by which the anatomical structures of a neuron projection are generated and organized. Morphogenesis pertains to the creation of form. A neuron projection is any process extending from a neural cell, such as axons or dendrites.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cell projection morphogenesis

The process by which the anatomical structures of a cell projection are generated and organized. Morphogenesis pertains to the creation of form.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of catalytic activity

Any process that modulates the activity of an enzyme.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cognition

The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of hydrolase activity

Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

positive regulation of hydrolase activity

Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.

nucleobase, nucleoside and nucleotide metabolic process

The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.

regulation of lipase activity

Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.

positive regulation of lipase activity

Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of molecular function

Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.

all

NA

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

cell projection organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

small molecule biosynthetic process

The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.

cell-cell signaling

Any process that mediates the transfer of information from one cell to another.

cellular component morphogenesis

The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.

signal transduction

The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

cellular component morphogenesis

The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

regulation of catalytic activity

Any process that modulates the activity of an enzyme.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

cellular nitrogen compound biosynthetic process

The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.

nucleobase, nucleoside and nucleotide metabolic process

The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.

nucleobase, nucleoside and nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides and nucleotides.

synaptic transmission

The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

neuron projection morphogenesis

The process by which the anatomical structures of a neuron projection are generated and organized. Morphogenesis pertains to the creation of form. A neuron projection is any process extending from a neural cell, such as axons or dendrites.

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

cell morphogenesis involved in differentiation

The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.

cell projection morphogenesis

The process by which the anatomical structures of a cell projection are generated and organized. Morphogenesis pertains to the creation of form.

cell projection morphogenesis

The process by which the anatomical structures of a cell projection are generated and organized. Morphogenesis pertains to the creation of form.

intracellular signal transduction

The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.

nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.

positive regulation of hydrolase activity

Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.

nucleobase, nucleoside and nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides and nucleotides.

neuron development

The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

neuron projection development

The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

cell morphogenesis involved in neuron differentiation

The process by which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.

learning or memory

The acquisition and processing of information and/or the storage and retrieval of this information over time.

central nervous system development

The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.

neurogenesis

Generation of cells within the nervous system.

brain development

The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).

central nervous system neuron differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.

forebrain development

The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).

positive regulation of lipase activity

Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.

nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).

neuron differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a neuron.

cerebral cortex neuron differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.

axonogenesis

Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells.

potassium ion transport

The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

positive regulation of phospholipase activity

Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.

nucleoside monophosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety.

G-protein signaling, coupled to cyclic nucleotide second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate.

cyclic nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.

G-protein signaling, coupled to cAMP nucleotide second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP.

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

voltage-gated potassium channel complex

A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

cell junction

A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.

axon

The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.

dendrite

A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

asymmetric synapse

A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

axon part

A part of an axon, a cell projection of a neuron.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

cation channel complex

An ion channel complex through which cations pass.

potassium channel complex

An ion channel complex through which potassium ions pass.

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

neuron projection

A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

neuronal cell body

The portion of a neuron that includes the nucleus, but excludes all cell projections such as axons and dendrites.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

axon terminus

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.

cell body

The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.

neuron projection terminus

The specialized, terminal region of a neuron projection such as an axon or a dendrite.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

synapse part

Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

synapse

The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

postsynaptic membrane

A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

synapse part

Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

postsynaptic membrane

A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

neuron projection terminus

The specialized, terminal region of a neuron projection such as an axon or a dendrite.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

axon terminus

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.

axon part

A part of an axon, a cell projection of a neuron.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

voltage-gated potassium channel complex

A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

voltage-gated potassium channel complex

A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

peptide receptor activity

Combining with an extracellular or intracellular peptide to initiate a change in cell activity.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

inositol or phosphatidylinositol phosphodiesterase activity

NA

phosphoinositide phospholipase C activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

phospholipase activity

Catalysis of the hydrolysis of a glycerophospholipid.

phospholipase C activity

Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transmembrane receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

G-protein coupled receptor activity

A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.

serotonin receptor activity

Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity.

hormone activity

The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.

neuropeptide hormone activity

The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

voltage-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons.

voltage-gated potassium channel activity

Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

potassium channel activity

Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

phosphoric diester hydrolase activity

Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.

drug binding

Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.

neuropeptide receptor activity

Combining with a neuropeptide to initiate a change in cell activity.

G-protein coupled amine receptor activity

A receptor that binds an extracellular amine and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

peptide receptor activity, G-protein coupled

Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

lipase activity

Catalysis of the hydrolysis of a lipid or phospholipid.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

hydrolase activity, acting on ester bonds

Catalysis of the hydrolysis of any ester bond.

passive transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.

voltage-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

ligand-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

voltage-gated cation channel activity

Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

neurotransmitter receptor activity

Combining with a neurotransmitter to initiate a change in cell activity.

neurotransmitter binding

Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.

peptide binding

Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.

phosphoric ester hydrolase activity

Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.

neuropeptide binding

Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).

amine binding

Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.

serotonin binding

Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

neuropeptide receptor activity

Combining with a neuropeptide to initiate a change in cell activity.

peptide receptor activity

Combining with an extracellular or intracellular peptide to initiate a change in cell activity.

neurotransmitter receptor activity

Combining with a neurotransmitter to initiate a change in cell activity.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

neuropeptide receptor activity

Combining with a neuropeptide to initiate a change in cell activity.

phospholipase C activity

Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

peptide receptor activity, G-protein coupled

Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.

phosphoinositide phospholipase C activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

voltage-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

voltage-gated cation channel activity

Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion.

voltage-gated potassium channel activity

Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0007268	2.108e-10	5.754	29 CHRM1, CRH, DRD1, EGR3, FRMPD4, GABRA2, GAD2, GJD2, GLRA3, GRIK1, GRIN2B, HCRTR2, HRH1, HTR1B, HTR2A, HTR2C, HTR6, KCNQ3, KCNQ5, MAPK1, NETO1, PDE7B, PDYN, PNOC, ROBO2, SHC3, SLIT1, SST, TACR1	287	synaptic transmission
GO:0019226	2.169e-10	6.616	31 CHRM1, CRH, DRD1, EGR3, FRMPD4, GABRA2, GAD2, GJD2, GLRA3, GRIK1, GRIN2B, HCRTR2, HRH1, HTR1B, HTR2A, HTR2C, HTR6, KCNMB2, KCNQ3, KCNQ5, MAPK1, NETO1, PDE7B, PDYN, PNOC, ROBO2, SCN1A, SHC3, SLIT1, SST, TACR1	330	transmission of nerve impulse
GO:0006811	3.735e-10	13.29	44 ANO3, ATP2B1, ATP6V1C1, CACNG3, DNM2, DRD1, GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B, HTR2A, HTR2C, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, NSF, OPRD1, P2RY12, PANX1, SCN1A, SCN3A, SCN3B, SLC10A4, SLC24A4, SLC39A10, SLC8A3, SLCO1C1, TRPC5	663	ion transport
GO:0007186	2.806e-09	8.34	33 ADRA1D, ATRNL1, CHRM1, CHRM3, DGKB, DGKI, DRD1, GABRA2, GABRA4, GPR26, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, KCNK2, MAS1, MC4R, NPY2R, OPRD1, P2RY12, PDYN, PNOC, RGS4, RXFP3, SST, TACR1, TRHR, VIP	416	G-protein coupled receptor protein signaling pathway
GO:0007267	1.755e-08	11.11	37 ADCYAP1, ADRA1D, CHRM1, CRH, DRD1, EGR3, FGF10, FRMPD4, GABRA2, GAD2, GJD2, GLRA3, GRIK1, GRIN2B, HCRTR2, HRH1, HTR1B, HTR2A, HTR2C, HTR6, KCNQ3, KCNQ5, MAPK1, MC4R, NETO1, PANX1, PCDH8, PCSK1, PDE7B, PDE8B, PDYN, PNOC, ROBO2, SHC3, SLIT1, SST, TACR1	554	cell-cell signaling
GO:0006813	3.913e-08	2.366	17 DRD1, HTR2A, KCNA3, KCNA4, KCNA6, KCNB2, KCNH4, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNS1, KCNV1, KCTD16, KCTD4, NSF, SLC24A4	118	potassium ion transport
GO:0030001	1.268e-07	8.219	30 ATP2B1, CACNG3, DNM2, DRD1, GRIN2B, HTR2A, HTR2C, KCNA3, KCNA4, KCNA6, KCNB2, KCNH4, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNS1, KCNV1, KCTD16, KCTD4, NSF, OPRD1, SCN1A, SCN3A, SCN3B, SLC10A4, SLC24A4, SLC39A10, SLC8A3, TRPC5	410	metal ion transport
GO:0015672	2.437e-07	5.092	23 ATP6V1C1, DRD1, HTR2A, KCNA3, KCNA4, KCNA6, KCNB2, KCNH4, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNS1, KCNV1, KCTD16, KCTD4, NSF, SCN1A, SCN3A, SCN3B, SLC10A4, SLC24A4, SLC8A3	254	monovalent inorganic cation transport
GO:0006812	2.729e-07	9.583	32 ATP2B1, ATP6V1C1, CACNG3, DNM2, DRD1, GRIN2B, HTR2A, HTR2C, KCNA3, KCNA4, KCNA6, KCNB2, KCNH4, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNS1, KCNV1, KCTD16, KCTD4, NSF, OPRD1, PANX1, SCN1A, SCN3A, SCN3B, SLC10A4, SLC24A4, SLC39A10, SLC8A3, TRPC5	478	cation transport
GO:0050877	1.570e-06	14.55	39 ADRA1D, CHRM1, CNTN5, COL11A1, CRH, DRD1, EGR3, FRMPD4, GABRA2, GAD2, GJD2, GLRA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1B, HTR2A, HTR2C, HTR6, KCNMB2, KCNQ3, KCNQ5, MAPK1, NETO1, OPRD1, PDE7B, PDYN, PLCB1, PNOC, ROBO2, RORB, SCN1A, SHC3, SLIT1, SST, TACR1, TSHZ3	726	neurological system process
GO:0007399	2.069e-06	18.58	45 BCL11B, CHRM1, CHRM3, CNTN3, DCLK1, DCX, DLX1, DLX2, DRD1, DRP2, DSCAM, EGR3, ENC1, EPHA4, FAM5B, FAM5C, FOXP2, GRIK1, IL1RAPL2, KAL1, LMO4, LPPR4, LRRC4C, MAS1, MDGA2, MEF2C, MTPN, NEUROD6, NRSN1, PCSK1, PLXNA4, RELA, ROBO2, RORB, SATB2, SEMA3A, SERPINI1, SHC3, SLIT1, SLITRK1, SLITRK2, SLITRK5, SYNJ1, TBR1, TRPC5	927	nervous system development
GO:0019932	1.324e-05	4.05	18 ADRA1D, CHRM1, DRD1, GPR26, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR4, HTR6, MC4R, NPY2R, OPRD1, P2RY12, PEX5L, RXFP3, TACR1	202	second-messenger-mediated signaling
GO:0007610	2.220e-05	7.738	25 CRH, DRD1, DSCAM, EPHA4, FGF10, GRIN2B, GRPR, HCRTR2, HTR1A, HTR1B, HTR2A, HTR2C, KAL1, MAPK1, MC4R, NETO1, NPY2R, OPRD1, PLCB1, ROBO2, SCG2, SCN1A, SHC3, SLIT1, TACR1	386	behavior
GO:0032501	2.538e-05	66.16	101 ADRA1D, BCL11A, BCL11B, CHRM1, CHRM3, CNTN3, CNTN5, COL11A1, CRH, DCLK1, DCX, DLX1, DLX2, DRD1, DRP2, DSCAM, EGR3, ENC1, EPHA4, FAM5B, FAM5C, FAT3, FGF10, FOXP2, FRMPD4, GABRA2, GAD2, GJD2, GLRA3, GRIK1, GRIN2B, GRPR, HCRTR2, HOPX, HRH1, HTR1B, HTR2A, HTR2C, HTR6, IL1RAPL2, KAL1, KCNB2, KCNMB2, KCNQ3, KCNQ5, LMNA, LMO4, LPPR4, LRRC4C, MAPK1, MAPK8, MAS1, MC4R, MDGA2, MEF2C, MEPE, MKL2, MMP16, MTPN, NDFIP1, NETO1, NEUROD6, NPY2R, NRG3, NRSN1, OPRD1, OSTN, P2RY12, PANX1, PCDH8, PCSK1, PDE7B, PDYN, PLCB1, PLXNA4, PNOC, PXN, RELA, ROBO2, RORB, SATB1, SATB2, SCG2, SCN1A, SEMA3A, SERPINI1, SHC3, SLIT1, SLITRK1, SLITRK2, SLITRK5, SPIN1, SST, SYNJ1, TACR1, TBR1, TRPC5, TSHZ3, UNC5D, VIP, ZBTB7B	3300	multicellular organismal process
GO:0003008	3.561e-05	20.01	44 ADRA1D, CHRM1, CHRM3, CNTN5, COL11A1, CRH, DRD1, EGR3, FGF10, FRMPD4, GABRA2, GAD2, GJD2, GLRA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1B, HTR2A, HTR2C, HTR6, KCNB2, KCNMB2, KCNQ3, KCNQ5, MAPK1, NETO1, OPRD1, PDE7B, PDYN, PLCB1, PNOC, PXN, ROBO2, RORB, SCN1A, SEMA3A, SHC3, SLIT1, SST, TACR1, TSHZ3	998	system process
GO:0019935	1.105e-04	2.125	12 ADRA1D, DRD1, GPR26, HTR1A, HTR1B, HTR4, HTR6, MC4R, NPY2R, OPRD1, P2RY12, PEX5L	106	cyclic-nucleotide-mediated signaling
GO:0007631	1.240e-04	1.123	9 CRH, DRD1, GRIN2B, HCRTR2, HTR1A, HTR1B, HTR2C, MC4R, TACR1	56	feeding behavior
GO:0007187	1.259e-04	1.784	11 ADRA1D, DRD1, GPR26, HTR1A, HTR1B, HTR4, HTR6, MC4R, NPY2R, OPRD1, P2RY12	89	G-protein signaling, coupled to cyclic nucleotide second messenger
GO:0007409	2.144e-04	3.568	15 BCL11B, DCLK1, DCX, DSCAM, EPHA4, KAL1, LPPR4, LRRC4C, ROBO2, SEMA3A, SLIT1, SLITRK1, SLITRK2, SLITRK5, TBR1	178	axonogenesis
GO:0023046	2.684e-04	40.56	68 ADRA1D, AKAP11, CDC42SE2, CHRM1, CHRM3, CNTNAP5, CRH, DNM2, DRD1, EGR3, EPHA4, FGF10, FRMPD4, GABRA2, GAD2, GJD2, GLRA3, GPR26, GRIA3, GRIK1, GRIN2B, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, IL1RAPL2, KCNH4, KCNMB2, KCNQ3, KCNQ5, MAP2K4, MAPK1, MAPK8, MAS1, MC4R, MKNK2, NDFIP1, NETO1, NLK, NPY2R, NRG3, OPRD1, P2RY12, PDE7B, PDE8B, PDYN, PEX5L, PLCB1, PLXNA4, PNOC, PRKG2, PXN, RAB3B, RELA, RGS4, ROBO2, RXFP3, SCG2, SCN1A, SHC3, SLIT1, SST, TACR1, UNC5D	2023	signaling process
GO:0007166	3.134e-04	24.14	47 ADCYAP1, ADRA1D, ATRNL1, CHRM1, CHRM3, DGKB, DGKI, DRD1, EPHA4, EPHA5, FGF10, GABRA2, GABRA4, GPR26, GRIA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, KCNK2, MAPK1, MAS1, MC4R, MKNK2, NLK, NPY2R, OPRD1, P2RY12, PDYN, PNOC, PXN, RELA, RGS4, RSPO2, RXFP3, SHC3, SST, TACR1, TRHR, VIP	1204	cell surface receptor linked signaling pathway
GO:0007200	4.279e-04	0.7217	7 CHRM1, DRD1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	36	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
GO:0023060	4.638e-04	40.44	67 ADRA1D, AKAP11, CDC42SE2, CHRM1, CHRM3, CNTNAP5, CRH, DNM2, DRD1, EGR3, EPHA4, FGF10, FRMPD4, GABRA2, GAD2, GJD2, GLRA3, GPR26, GRIK1, GRIN2B, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, IL1RAPL2, KCNH4, KCNMB2, KCNQ3, KCNQ5, MAP2K4, MAPK1, MAPK8, MAS1, MC4R, MKNK2, NDFIP1, NETO1, NLK, NPY2R, NRG3, OPRD1, P2RY12, PDE7B, PDE8B, PDYN, PEX5L, PLCB1, PLXNA4, PNOC, PRKG2, PXN, RAB3B, RELA, RGS4, ROBO2, RXFP3, SCG2, SCN1A, SHC3, SLIT1, SST, TACR1, UNC5D	2017	signal transmission
GO:0048667	5.413e-04	3.889	15 BCL11B, DCLK1, DCX, DSCAM, EPHA4, KAL1, LPPR4, LRRC4C, ROBO2, SEMA3A, SLIT1, SLITRK1, SLITRK2, SLITRK5, TBR1	194	cell morphogenesis involved in neuron differentiation
GO:0007417	7.554e-04	7.257	21 BCL11B, DCLK1, DCX, DLX1, DLX2, DRD1, DRP2, FOXP2, GRIK1, IL1RAPL2, MAS1, MDGA2, MTPN, PCSK1, ROBO2, RORB, SERPINI1, SHC3, SLIT1, SYNJ1, TBR1	362	central nervous system development
GO:0048812	7.805e-04	4.029	15 BCL11B, DCLK1, DCX, DSCAM, EPHA4, KAL1, LPPR4, LRRC4C, ROBO2, SEMA3A, SLIT1, SLITRK1, SLITRK2, SLITRK5, TBR1	201	neuron projection morphogenesis
GO:0021953	7.936e-04	1.103	8 BCL11B, DCLK1, DCX, DLX1, DLX2, DRD1, MDGA2, MTPN	55	central nervous system neuron differentiation
GO:0007613	9.282e-04	0.8219	7 CRH, DRD1, GRIN2B, HTR2A, NETO1, PLCB1, TACR1	41	memory
GO:0007154	1.534e-03	26.64	48 ADCYAP1, ADRA1D, CDC42SE2, CHRM1, CRH, DRD1, EGR3, FGF10, FREM3, FRMPD4, GABRA2, GAD2, GJD2, GLRA3, GRIK1, GRIN2B, HCRTR2, HRH1, HTR1B, HTR2A, HTR2C, HTR6, KCNMB2, KCNQ3, KCNQ5, MAPK1, MC4R, NDFIP1, NETO1, NLK, PANX1, PCDH8, PCSK1, PDE7B, PDE8B, PDYN, PEX5L, PNOC, RELA, RGS4, ROBO2, SCN1A, SHC3, SLC8A3, SLIT1, SNTG1, SST, TACR1	1329	cell communication
GO:0023052	1.539e-03	56.07	83 ADCYAP1, ADRA1D, AKAP11, ATRNL1, CDC42SE2, CHRM1, CHRM3, CNTNAP5, CRH, DGKB, DGKI, DNM2, DRD1, EGR3, EPHA4, EPHA5, FGF10, FRMPD4, GABRA2, GABRA4, GAD2, GJD2, GLRA3, GPR26, GRIA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, IL1RAPL2, KCNH4, KCNK2, KCNMB2, KCNQ3, KCNQ5, LMNA, MAP2K4, MAPK1, MAPK8, MAS1, MC4R, MKNK2, NDFIP1, NETO1, NLK, NPY2R, NRG3, OPRD1, P2RY12, PANX1, PCDH8, PCSK1, PDE7B, PDE8B, PDYN, PEX5L, PLCB1, PLXNA4, PNOC, PRKG2, PXN, RAB3B, RELA, RGS4, ROBO2, RSPO2, RXFP3, SCG2, SCN1A, SHC3, SLIT1, SST, TACR1, TRHR, UNC5D, VIP	2797	signaling
GO:0048699	1.552e-03	9.522	24 BCL11B, DCLK1, DCX, DLX1, DLX2, DRD1, DSCAM, EPHA4, KAL1, LPPR4, LRRC4C, MDGA2, MTPN, RELA, ROBO2, RORB, SATB2, SEMA3A, SLIT1, SLITRK1, SLITRK2, SLITRK5, SYNJ1, TBR1	475	generation of neurons
GO:0019933	1.682e-03	1.604	9 ADRA1D, DRD1, GPR26, HTR1A, MC4R, NPY2R, OPRD1, P2RY12, PEX5L	80	cAMP-mediated signaling
GO:0022008	1.746e-03	10.24	25 BCL11B, DCLK1, DCX, DLX1, DLX2, DRD1, DSCAM, EPHA4, KAL1, LPPR4, LRRC4C, MDGA2, MTPN, PCSK1, RELA, ROBO2, RORB, SATB2, SEMA3A, SLIT1, SLITRK1, SLITRK2, SLITRK5, SYNJ1, TBR1	511	neurogenesis
GO:0007202	2.276e-03	0.9623	7 CHRM1, DRD1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	48	activation of phospholipase C activity
GO:0010863	2.276e-03	0.9623	7 CHRM1, DRD1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	48	positive regulation of phospholipase C activity
GO:0007188	2.732e-03	1.343	8 ADRA1D, DRD1, GPR26, HTR1A, MC4R, NPY2R, OPRD1, P2RY12	67	G-protein signaling, coupled to cAMP nucleotide second messenger
GO:0044057	3.148e-03	5.192	16 ADRA1D, CHRM3, CRH, DRD1, FGF10, GRIK1, GRIN2B, HTR1B, HTR2A, KCNB2, KCNMB2, NETO1, OPRD1, SEMA3A, TACR1, TSHZ3	259	regulation of system process
GO:0010518	3.175e-03	1.022	7 CHRM1, DRD1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	51	positive regulation of phospholipase activity
GO:0051234	3.504e-03	45.15	69 ANO3, ATP2B1, ATP6V1C1, CACNG3, CDC42SE2, CRH, DCLK1, DNM2, DRD1, FGF10, GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B, HTR1B, HTR2A, HTR2C, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, KLHL2, LMNA, MAPK1, MC4R, NAPG, NCALD, NDFIP1, NGB, NSF, OPRD1, P2RY12, PANX1, PCSK1, PDE8B, PEX5L, RAB3B, SCG2, SCN1A, SCN3A, SCN3B, SLC10A4, SLC24A4, SLC35F1, SLC39A10, SLC8A3, SLCO1C1, SLIT1, STAU2, SYNJ1, TACR1, TRPC5, VIP, ZMAT3	2252	establishment of localization
GO:0007210	3.698e-03	0.1002	3 HTR1A, HTR2A, HTR2C	5	serotonin receptor signaling pathway
GO:0021892	3.698e-03	0.1002	3 DLX1, DLX2, DRD1	5	cerebral cortex GABAergic interneuron differentiation
GO:0048858	3.765e-03	4.731	15 BCL11B, DCLK1, DCX, DSCAM, EPHA4, KAL1, LPPR4, LRRC4C, ROBO2, SEMA3A, SLIT1, SLITRK1, SLITRK2, SLITRK5, TBR1	236	cell projection morphogenesis
GO:0010517	3.938e-03	1.062	7 CHRM1, DRD1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	53	regulation of phospholipase activity
GO:0009187	4.096e-03	2.265	10 ADCYAP1, DRD1, GPR26, HTR1A, HTR1B, HTR2C, MC4R, NPY2R, OPRD1, PDE8B	113	cyclic nucleotide metabolic process
GO:0007611	4.232e-03	1.844	9 CRH, DRD1, GRIN2B, GRPR, HTR2A, NETO1, PLCB1, SHC3, TACR1	92	learning or memory
GO:0006810	4.310e-03	44.62	68 ANO3, ATP2B1, ATP6V1C1, CACNG3, CDC42SE2, CRH, DCLK1, DNM2, DRD1, FGF10, GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B, HTR1B, HTR2A, HTR2C, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, KLHL2, LMNA, MAPK1, MC4R, NAPG, NCALD, NDFIP1, NGB, NSF, OPRD1, P2RY12, PANX1, PCSK1, PDE8B, PEX5L, RAB3B, SCG2, SCN1A, SCN3A, SCN3B, SLC10A4, SLC24A4, SLC35F1, SLC39A10, SLC8A3, SLCO1C1, STAU2, SYNJ1, TACR1, TRPC5, VIP, ZMAT3	2226	transport
GO:0009190	5.213e-03	1.904	9 ADCYAP1, DRD1, GPR26, HTR1A, HTR1B, HTR2C, MC4R, NPY2R, OPRD1	95	cyclic nucleotide biosynthetic process
GO:0060193	5.303e-03	1.123	7 CHRM1, DRD1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	56	positive regulation of lipase activity
GO:0000904	5.754e-03	4.952	15 BCL11B, DCLK1, DCX, DSCAM, EPHA4, KAL1, LPPR4, LRRC4C, ROBO2, SEMA3A, SLIT1, SLITRK1, SLITRK2, SLITRK5, TBR1	247	cell morphogenesis involved in differentiation
GO:0032990	5.754e-03	4.952	15 BCL11B, DCLK1, DCX, DSCAM, EPHA4, KAL1, LPPR4, LRRC4C, ROBO2, SEMA3A, SLIT1, SLITRK1, SLITRK2, SLITRK5, TBR1	247	cell part morphogenesis
GO:0030182	6.169e-03	8.62	21 BCL11B, DCLK1, DCX, DLX1, DLX2, DRD1, DSCAM, EPHA4, KAL1, LPPR4, LRRC4C, MDGA2, MTPN, ROBO2, RORB, SEMA3A, SLIT1, SLITRK1, SLITRK2, SLITRK5, TBR1	430	neuron differentiation
GO:0035249	6.192e-03	0.5212	5 DRD1, GRIK1, HTR1B, HTR2A, SHC3	26	synaptic transmission, glutamatergic
GO:0050890	6.329e-03	1.965	9 CRH, DRD1, GRIN2B, GRPR, HTR2A, NETO1, PLCB1, SHC3, TACR1	98	cognition
GO:0021895	6.469e-03	0.1203	3 DLX1, DLX2, DRD1	6	cerebral cortex neuron differentiation
GO:0048731	9.333e-03	39.93	61 BCL11A, BCL11B, CHRM1, CHRM3, CNTN3, CRH, DCLK1, DCX, DLX1, DLX2, DRD1, DRP2, DSCAM, EGR3, ENC1, EPHA4, FAM5B, FAM5C, FGF10, FOXP2, GRIK1, GRIN2B, IL1RAPL2, KAL1, LMNA, LMO4, LPPR4, LRRC4C, MAPK1, MAS1, MDGA2, MEF2C, MEPE, MKL2, MTPN, NDFIP1, NEUROD6, NPY2R, NRG3, NRSN1, PCDH8, PCSK1, PLXNA4, RELA, ROBO2, RORB, SATB1, SATB2, SCG2, SEMA3A, SERPINI1, SHC3, SLIT1, SLITRK1, SLITRK2, SLITRK5, SYNJ1, TBR1, TRPC5, TSHZ3, ZBTB7B	1992	system development
GO:0031175	9.670e-03	5.252	15 BCL11B, DCLK1, DCX, DSCAM, EPHA4, KAL1, LPPR4, LRRC4C, ROBO2, SEMA3A, SLIT1, SLITRK1, SLITRK2, SLITRK5, TBR1	262	neuron projection development
GO:0048666	1.038e-02	6.495	17 BCL11B, DCLK1, DCX, DRD1, DSCAM, EPHA4, KAL1, LPPR4, LRRC4C, ROBO2, RORB, SEMA3A, SLIT1, SLITRK1, SLITRK2, SLITRK5, TBR1	324	neuron development
GO:0048015	1.046e-02	1.283	7 CHRM1, DRD1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	64	phosphoinositide-mediated signaling
GO:0007156	1.080e-02	2.145	9 CDH12, CDH8, CDH9, DSG3, FAT3, PCDH19, PCDH20, PCDH8, ROBO2	107	homophilic cell adhesion
GO:0030817	1.090e-02	1.704	8 ADCYAP1, DRD1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	85	regulation of cAMP biosynthetic process
GO:0060191	1.128e-02	1.303	7 CHRM1, DRD1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	65	regulation of lipase activity
GO:0035556	1.129e-02	19.12	35 ADRA1D, AKAP11, CHRM1, DRD1, FGF10, GPR26, GRIN2B, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, MAP2K4, MAPK1, MAPK8, MAS1, MC4R, MKNK2, NDFIP1, NLK, NPY2R, NRG3, OPRD1, P2RY12, PEX5L, RAB3B, RELA, RGS4, RXFP3, SCG2, SHC3, TACR1	954	intracellular signal transduction
GO:0006171	1.156e-02	1.724	8 ADCYAP1, DRD1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	86	cAMP biosynthetic process
GO:0021537	1.215e-02	1.323	7 DLX1, DLX2, DRD1, FOXP2, MAS1, ROBO2, SLIT1	66	telencephalon development
GO:0030814	1.234e-02	1.744	8 ADCYAP1, DRD1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	87	regulation of cAMP metabolic process
GO:0051179	1.304e-02	51.98	74 ANO3, ATP2B1, ATP6V1C1, CACNG3, CDC42SE2, CRH, DCLK1, DCX, DNM2, DRD1, DSCAM, FGF10, GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B, HTR1B, HTR2A, HTR2C, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, KLHL2, LMNA, MAPK1, MC4R, NAPG, NCALD, NDFIP1, NGB, NSF, OPRD1, P2RY12, PANX1, PCSK1, PDE8B, PEX5L, RAB3B, SATB2, SCG2, SCN1A, SCN3A, SCN3B, SEMA3A, SLC10A4, SLC24A4, SLC35F1, SLC39A10, SLC8A3, SLCO1C1, SLIT1, SST, STAU2, SYNJ1, TACR1, TRPC5, VIP, ZMAT3	2593	localization
GO:0051966	1.354e-02	0.3608	4 DRD1, GRIK1, HTR1B, HTR2A	18	regulation of synaptic transmission, glutamatergic
GO:0021882	1.396e-02	0.04009	2 DLX1, DLX2	2	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0021893	1.396e-02	0.04009	2 DLX1, DLX2	2	cerebral cortex GABAergic interneuron fate commitment
GO:0021898	1.396e-02	0.04009	2 DLX1, DLX2	2	commitment of multipotent stem cells to the neuronal lineage in the forebrain
GO:0035106	1.396e-02	0.04009	2 DRD1, TACR1	2	operant conditioning
GO:0007270	1.427e-02	0.9823	6 DRD1, GRIK1, HTR1B, HTR2A, SHC3, TACR1	49	nerve-nerve synaptic transmission
GO:0048841	1.431e-02	0.1604	3 DSCAM, SEMA3A, SLIT1	8	regulation of axon extension involved in axon guidance
GO:0007420	1.473e-02	4.932	14 DCLK1, DCX, DLX1, DLX2, DRD1, FOXP2, MAS1, MTPN, PCSK1, ROBO2, RORB, SLIT1, SYNJ1, TBR1	246	brain development
GO:0030802	1.575e-02	1.824	8 ADCYAP1, DRD1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	91	regulation of cyclic nucleotide biosynthetic process
GO:0030808	1.575e-02	1.824	8 ADCYAP1, DRD1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	91	regulation of nucleotide biosynthetic process
GO:0009123	1.600e-02	2.787	10 ADCYAP1, DRD1, GPR26, HTR1A, HTR1B, HTR2C, MC4R, NPY2R, OPRD1, PDE8B	139	nucleoside monophosphate metabolic process
GO:0006164	1.673e-02	3.869	12 ADCYAP1, AK5, ATP2B1, ATP6V1C1, DRD1, GPR26, HTR1A, HTR1B, HTR2C, MC4R, NPY2R, OPRD1	193	purine nucleotide biosynthetic process
GO:0009124	1.733e-02	2.325	9 ADCYAP1, DRD1, GPR26, HTR1A, HTR1B, HTR2C, MC4R, NPY2R, OPRD1	116	nucleoside monophosphate biosynthetic process
GO:0046058	1.979e-02	1.904	8 ADCYAP1, DRD1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	95	cAMP metabolic process
GO:0030799	2.082e-02	1.925	8 ADCYAP1, DRD1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	96	regulation of cyclic nucleotide metabolic process
GO:0055085	2.105e-02	11.77	24 ATP6V1C1, DRD1, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, LMNA, MAPK1, OPRD1, SCN1A, SCN3A, SLC24A4, SLC39A10, SLC8A3, TRPC5, ZMAT3	587	transmembrane transport
GO:0007411	2.106e-02	1.483	7 DSCAM, EPHA4, KAL1, ROBO2, SEMA3A, SLIT1, TBR1	74	axon guidance
GO:0048675	2.151e-02	0.7217	5 DCLK1, DCX, DSCAM, SEMA3A, SLIT1	36	axon extension
GO:0007623	2.311e-02	1.103	6 ARNTL2, CRH, DRD1, EGR3, KCNH7, RORB	55	circadian rhythm
GO:0048846	2.498e-02	0.2005	3 DSCAM, SEMA3A, SLIT1	10	axon extension involved in axon guidance
GO:0019233	2.797e-02	0.7818	5 GRIN2B, HTR2A, MAPK1, OPRD1, TACR1	39	sensory perception of pain
GO:0042310	2.797e-02	0.7818	5 ADRA1D, CHRM3, HTR2A, KCNMB2, TACR1	39	vasoconstriction
GO:0021766	2.818e-02	0.4611	4 DLX1, DLX2, DRD1, MAS1	23	hippocampus development
GO:0006816	3.080e-02	3.127	10 ATP2B1, CACNG3, DRD1, GRIN2B, HTR2A, HTR2C, OPRD1, SLC24A4, SLC8A3, TRPC5	156	calcium ion transport
GO:0048169	3.081e-02	0.2205	3 DRD1, GRIN2B, NETO1	11	regulation of long-term neuronal synaptic plasticity
GO:0048521	3.081e-02	0.2205	3 CRH, DRD1, ROBO2	11	negative regulation of behavior
GO:0048856	3.111e-02	43.24	62 BCL11A, BCL11B, CHRM1, CHRM3, CNTN3, CRH, DCLK1, DCX, DLX1, DLX2, DRD1, DRP2, DSCAM, EGR3, ENC1, EPHA4, FAM5B, FAM5C, FGF10, FOXP2, GRIK1, GRIN2B, HOPX, IL1RAPL2, KAL1, LMNA, LMO4, LPPR4, LRRC4C, MAPK1, MAS1, MDGA2, MEF2C, MEPE, MKL2, MTPN, NDFIP1, NEUROD6, NPY2R, NRG3, NRSN1, PCDH8, PCSK1, PLXNA4, RELA, ROBO2, RORB, SATB1, SATB2, SCG2, SEMA3A, SERPINI1, SHC3, SLIT1, SLITRK1, SLITRK2, SLITRK5, SYNJ1, TBR1, TRPC5, TSHZ3, ZBTB7B	2157	anatomical structure development
GO:0021877	3.123e-02	0.06014	2 DLX1, DLX2	3	forebrain neuron fate commitment
GO:0042321	3.123e-02	0.06014	2 CRH, DRD1	3	negative regulation of circadian sleep/wake cycle, sleep
GO:0042754	3.123e-02	0.06014	2 CRH, DRD1	3	negative regulation of circadian rhythm
GO:0048715	3.123e-02	0.06014	2 DLX1, DLX2	3	negative regulation of oligodendrocyte differentiation
GO:0051961	3.123e-02	0.06014	2 ROBO2, SLIT1	3	negative regulation of nervous system development
GO:0051964	3.123e-02	0.06014	2 ROBO2, SLIT1	3	negative regulation of synaptogenesis
GO:0008306	3.182e-02	0.4811	4 DRD1, GRIN2B, NETO1, TACR1	24	associative learning
GO:0014013	3.182e-02	0.4811	4 DLX1, DLX2, RELA, SYNJ1	24	regulation of gliogenesis
GO:0051705	3.182e-02	0.4811	4 DRD1, GRIN2B, GRPR, TACR1	24	behavioral interaction between organisms
GO:0007612	3.306e-02	0.8219	5 DRD1, GRIN2B, NETO1, PLCB1, TACR1	41	learning
GO:0048588	3.306e-02	0.8219	5 DCLK1, DCX, DSCAM, SEMA3A, SLIT1	41	developmental cell growth
GO:0007275	3.314e-02	47.83	67 ADRA1D, BCL11A, BCL11B, CHRM1, CHRM3, CNTN3, CRH, DCLK1, DCX, DLX1, DLX2, DRD1, DRP2, DSCAM, EGR3, ENC1, EPHA4, FAM5B, FAM5C, FAT3, FGF10, FOXP2, GRIK1, GRIN2B, HOPX, IL1RAPL2, KAL1, LMNA, LMO4, LPPR4, LRRC4C, MAPK1, MAS1, MDGA2, MEF2C, MEPE, MKL2, MTPN, NDFIP1, NEUROD6, NPY2R, NRG3, NRSN1, OSTN, PCDH8, PCSK1, PLXNA4, RELA, ROBO2, RORB, SATB1, SATB2, SCG2, SEMA3A, SERPINI1, SHC3, SLIT1, SLITRK1, SLITRK2, SLITRK5, SPIN1, SYNJ1, TBR1, TRPC5, TSHZ3, UNC5D, ZBTB7B	2386	multicellular organismal development
GO:0050795	3.627e-02	1.243	6 CRH, DRD1, FGF10, HTR1A, ROBO2, SCG2	62	regulation of behavior
GO:0030900	3.659e-02	2.686	9 DCLK1, DLX1, DLX2, DRD1, FOXP2, MAS1, PCSK1, ROBO2, SLIT1	134	forebrain development
GO:0009165	3.735e-02	4.39	12 ADCYAP1, AK5, ATP2B1, ATP6V1C1, DRD1, GPR26, HTR1A, HTR1B, HTR2C, MC4R, NPY2R, OPRD1	219	nucleotide biosynthetic process
GO:0021772	3.758e-02	0.2406	3 DLX2, ROBO2, SLIT1	12	olfactory bulb development
GO:0015674	3.761e-02	3.809	11 ATP2B1, CACNG3, DNM2, DRD1, GRIN2B, HTR2A, HTR2C, OPRD1, SLC24A4, SLC8A3, TRPC5	190	di-, tri-valent inorganic cation transport
GO:0021543	3.870e-02	0.862	5 DLX1, DLX2, DRD1, FOXP2, MAS1	43	pallium development
GO:0070838	3.905e-02	3.268	10 ATP2B1, CACNG3, DRD1, GRIN2B, HTR2A, HTR2C, OPRD1, SLC24A4, SLC8A3, TRPC5	163	divalent metal ion transport
GO:0000902	4.301e-02	6.375	15 BCL11B, DCLK1, DCX, DSCAM, EPHA4, KAL1, LPPR4, LRRC4C, ROBO2, SEMA3A, SLIT1, SLITRK1, SLITRK2, SLITRK5, TBR1	318	cell morphogenesis
GO:0034404	4.408e-02	4.511	12 ADCYAP1, AK5, ATP2B1, ATP6V1C1, DRD1, GPR26, HTR1A, HTR1B, HTR2C, MC4R, NPY2R, OPRD1	225	nucleobase, nucleoside and nucleotide biosynthetic process
GO:0034654	4.408e-02	4.511	12 ADCYAP1, AK5, ATP2B1, ATP6V1C1, DRD1, GPR26, HTR1A, HTR1B, HTR2C, MC4R, NPY2R, OPRD1	225	nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process
GO:0048468	4.409e-02	12.69	24 BCL11B, DCLK1, DCX, DLX1, DLX2, DRD1, DSCAM, EPHA4, FGF10, KAL1, LMNA, LPPR4, LRRC4C, RELA, ROBO2, RORB, SATB2, SEMA3A, SLIT1, SLITRK1, SLITRK2, SLITRK5, SYNJ1, TBR1	633	cell development
GO:0021988	4.502e-02	0.2606	3 DLX2, ROBO2, SLIT1	13	olfactory lobe development
GO:0043279	4.512e-02	0.9021	5 DRD1, HTR1B, PCSK1, RELA, TACR1	45	response to alkaloid
GO:0001508	4.582e-02	1.323	6 DRD1, GJD2, GRIN2B, KCNMB2, SCN1A, TACR1	66	regulation of action potential

Id	Pvalue	ExpCount	Count	Size	Term
GO:0034702	5.300e-12	3.434	24 ANO3, CACNG3, GABRA2, GABRA4, GLRA3, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SCN1A, SCN3A, TRPC5	170	ion channel complex
GO:0034703	9.044e-12	2.283	20 CACNG3, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SCN1A, SCN3A, TRPC5	113	cation channel complex
GO:0008076	6.419e-11	1.454	16 KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4	72	voltage-gated potassium channel complex
GO:0034705	6.419e-11	1.454	16 KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4	72	potassium channel complex
GO:0031224	2.148e-10	75.09	126 ADRA1D, ANO3, ATP2B1, ATRNL1, B3GALT1, C11orf87, C13orf36, CACNG3, CBLN2, CDH12, CDH8, CDH9, CHRM1, CHRM3, CHSY3, CNTN3, CNTN5, CNTNAP5, CSMD3, DCLK1, DPP10, DRD1, DSCAM, DSG3, EPHA4, EPHA5, EPHX4, FAR2, FAT3, FLRT2, FREM3, GABRA2, GABRA4, GAD2, GALNTL6, GJD2, GLRA3, GPR149, GPR26, GPR83, GRIA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, IL1RAPL2, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LINGO2, LMTK2, LPPR4, LPPR5, LRFN2, LRFN5, LRRC4C, LRRC55, LRRC8B, LRTM2, MARCH1, MAS1, MC4R, MCHR2, MDGA2, MMD, MMP16, NDFIP1, NETO1, NPY2R, NRG3, NRSN1, OPRD1, P2RY12, PANX1, PCDH19, PCDH20, PCDH8, PLXNA4, PRRG3, RNF24, ROBO2, RXFP1, RXFP3, SCN1A, SCN3A, SCN3B, SLC10A4, SLC24A4, SLC35F1, SLC39A10, SLC8A3, SLCO1C1, SLITRK1, SLITRK2, SLITRK5, ST6GALNAC5, STYK1, TACR1, TMEM132D, TMEM196, TMEM200A, TRHR, TRPC5, UNC5D, XKR4	3717	intrinsic to membrane
GO:0016021	1.507e-09	73.49	122 ADRA1D, ANO3, ATP2B1, ATRNL1, B3GALT1, C11orf87, C13orf36, CACNG3, CBLN2, CDH12, CDH8, CDH9, CHRM1, CHRM3, CHSY3, CNTNAP5, CSMD3, DCLK1, DPP10, DRD1, DSCAM, DSG3, EPHA4, EPHA5, EPHX4, FAR2, FAT3, FLRT2, FREM3, GABRA2, GABRA4, GALNTL6, GJD2, GLRA3, GPR149, GPR26, GPR83, GRIA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, IL1RAPL2, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LINGO2, LMTK2, LPPR4, LPPR5, LRFN2, LRFN5, LRRC4C, LRRC55, LRRC8B, LRTM2, MARCH1, MAS1, MC4R, MCHR2, MMD, MMP16, NDFIP1, NETO1, NPY2R, NRG3, NRSN1, OPRD1, P2RY12, PANX1, PCDH19, PCDH20, PCDH8, PLXNA4, PRRG3, RNF24, ROBO2, RXFP1, RXFP3, SCN1A, SCN3A, SCN3B, SLC10A4, SLC24A4, SLC35F1, SLC39A10, SLC8A3, SLCO1C1, SLITRK1, SLITRK2, SLITRK5, ST6GALNAC5, STYK1, TACR1, TMEM132D, TMEM196, TMEM200A, TRHR, TRPC5, UNC5D, XKR4	3638	integral to membrane
GO:0005887	1.594e-09	18.67	51 ADRA1D, ATP2B1, CHRM1, CHRM3, DCLK1, DRD1, DSCAM, EPHA4, EPHA5, FLRT2, GABRA4, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR4, HTR6, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LPPR4, MAS1, MMD, MMP16, NPY2R, NRG3, OPRD1, PCDH8, RXFP3, SCN1A, SCN3A, TACR1, TRHR, TRPC5	924	integral to plasma membrane
GO:0005886	1.813e-09	53.01	98 ADRA1D, ATP2B1, ATP6V1C1, CACNG3, CAMK2A, CBLN4, CDC42SE2, CDH12, CDH8, CDH9, CHRM1, CHRM3, CNTN3, CNTN5, CSMD3, DCLK1, DGKB, DNM2, DRD1, DRP2, DSCAM, DSG3, EPHA4, EPHA5, FAT3, FGF10, FLRT2, GABRA2, GABRA4, GAD2, GJD2, GLRA3, GPR149, GPR26, GPR83, GRIA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LPPR4, LRFN2, MARCH1, MAS1, MC4R, MCHR2, MDGA2, MMD, MMP16, NETO1, NPY2R, NRG3, OPRD1, P2RY12, PANX1, PCDH19, PCDH20, PCDH8, PDYN, PLXNA4, PRICKLE2, PXN, RAB3B, RIMBP2, ROBO2, RXFP1, RXFP3, SCN1A, SCN3A, SCN3B, SNTG1, STYK1, TACR1, TRHR, TRPC5	2624	plasma membrane
GO:0031226	3.275e-09	19.07	51 ADRA1D, ATP2B1, CHRM1, CHRM3, DCLK1, DRD1, DSCAM, EPHA4, EPHA5, FLRT2, GABRA4, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR4, HTR6, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LPPR4, MAS1, MMD, MMP16, NPY2R, NRG3, OPRD1, PCDH8, RXFP3, SCN1A, SCN3A, TACR1, TRHR, TRPC5	944	intrinsic to plasma membrane
GO:0044425	3.870e-09	86.6	135 ADRA1D, ANO3, ATP2B1, ATP6V1C1, ATRNL1, B3GALT1, C11orf87, C13orf36, CACNG3, CAMK2A, CBLN2, CBLN4, CDH12, CDH8, CDH9, CHRM1, CHRM3, CHSY3, CNTN3, CNTN5, CNTNAP5, CSMD3, DCLK1, DNM2, DPP10, DRD1, DSCAM, DSG3, EPHA4, EPHA5, EPHX4, FAR2, FAT3, FLRT2, FREM3, GABRA2, GABRA4, GAD2, GALNTL6, GJD2, GLRA3, GPR149, GPR26, GPR83, GRIA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, IL1RAPL2, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LINGO2, LMTK2, LPPR4, LPPR5, LRFN2, LRFN5, LRRC4C, LRRC55, LRRC8B, LRTM2, MARCH1, MAS1, MC4R, MCHR2, MDGA2, MMD, MMP16, NCALD, NDFIP1, NETO1, NPY2R, NRG3, NRSN1, OPRD1, P2RY12, PANX1, PCDH19, PCDH20, PCDH8, PLXNA4, PRICKLE2, PRRG3, PXN, RIMBP2, RNF24, ROBO2, RXFP1, RXFP3, SCN1A, SCN3A, SCN3B, SLC10A4, SLC24A4, SLC35F1, SLC39A10, SLC8A3, SLCO1C1, SLITRK1, SLITRK2, SLITRK5, SNTG1, ST6GALNAC5, STYK1, TACR1, TMEM132D, TMEM196, TMEM200A, TRHR, TRPC5, UNC5D, XKR4	4287	membrane part
GO:0044459	1.184e-08	32.16	69 ADRA1D, ATP2B1, CACNG3, CAMK2A, CBLN4, CHRM1, CHRM3, DCLK1, DNM2, DRD1, DSCAM, DSG3, EPHA4, EPHA5, FLRT2, GABRA2, GABRA4, GAD2, GJD2, GLRA3, GRIA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR4, HTR6, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LPPR4, LRFN2, MAS1, MMD, MMP16, NETO1, NPY2R, NRG3, OPRD1, PANX1, PCDH8, PRICKLE2, PXN, RIMBP2, ROBO2, RXFP3, SCN1A, SCN3A, SNTG1, TACR1, TRHR, TRPC5	1592	plasma membrane part
GO:0030424	1.923e-06	2.99	16 CHRM1, CHRM3, DRD1, DSCAM, GAD2, GRIA3, HTR1A, KCNJ6, MAPK1, MTPN, OPRD1, PCSK1, ROBO2, SACS, SCN1A, SEMA3A	148	axon
GO:0043005	2.267e-06	6.182	23 CHRM1, CHRM3, DRD1, DSCAM, FRMPD4, GAD2, GRIA3, GRIN2B, HTR1A, HTR2A, KCNJ6, MAPK1, MTPN, NRSN1, NSF, OPRD1, PCSK1, PEX5L, ROBO2, SACS, SCN1A, SEMA3A, TACR1	306	neuron projection
GO:0016020	2.704e-06	104	144 ADRA1D, ANO3, ATP2B1, ATP6V1C1, ATRNL1, B3GALT1, C11orf87, C13orf36, CACNG3, CAMK2A, CBLN2, CBLN4, CDC42SE2, CDH12, CDH8, CDH9, CHRM1, CHRM3, CHSY3, CNTN3, CNTN5, CNTNAP5, CSMD3, DCLK1, DGKB, DNM2, DPP10, DRD1, DRP2, DSCAM, DSG3, EPHA4, EPHA5, EPHX4, FAR2, FAT3, FGF10, FLRT2, FREM3, GABRA2, GABRA4, GAD2, GALNTL6, GJD2, GLRA3, GPR149, GPR26, GPR83, GRIA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, IL1RAPL2, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LINGO2, LMTK2, LPPR4, LPPR5, LRFN2, LRFN5, LRRC4C, LRRC55, LRRC8B, LRTM2, MARCH1, MAS1, MC4R, MCHR2, MDGA2, MMD, MMP16, NAPG, NCALD, NDFIP1, NETO1, NPY2R, NRG3, NRSN1, OPRD1, P2RY12, PANX1, PCDH19, PCDH20, PCDH8, PDYN, PEX5L, PLXNA4, PRICKLE2, PRRG3, PXN, RAB3B, RIMBP2, RNF24, ROBO2, RXFP1, RXFP3, SCN1A, SCN3A, SCN3B, SEMA3A, SLC10A4, SLC24A4, SLC35F1, SLC39A10, SLC8A3, SLCO1C1, SLITRK1, SLITRK2, SLITRK5, SNTG1, ST6GALNAC5, STYK1, TACR1, TMEM132D, TMEM196, TMEM200A, TRHR, TRPC5, UNC5D, XKR4	5148	membrane
GO:0030425	1.122e-05	3.01	15 CHRM1, CHRM3, DRD1, FRMPD4, GRIA3, GRIN2B, HTR2A, KCNJ6, MAPK1, NSF, PCSK1, PEX5L, SACS, SEMA3A, TACR1	149	dendrite
GO:0045211	4.171e-05	2.525	13 CHRM1, CHRM3, DNM2, GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B, KCTD16, LRFN2, NETO1, OPRD1	125	postsynaptic membrane
GO:0033267	9.227e-05	1.232	9 CHRM1, CHRM3, GRIA3, HTR1A, MAPK1, OPRD1, PCSK1, ROBO2, SCN1A	61	axon part
GO:0044456	2.080e-04	4.384	16 CAMK2A, CHRM1, CHRM3, DNM2, GABRA2, GABRA4, GAD2, GLRA3, GRIA3, GRIK1, GRIN2B, KCTD16, LRFN2, NETO1, OPRD1, RAB3B	217	synapse part
GO:0045202	5.358e-04	5.858	18 CAMK2A, CBLN4, CHRM1, CHRM3, DNM2, GABRA2, GABRA4, GAD2, GLRA3, GRIA3, GRIK1, GRIN2B, KCTD16, LRFN2, NETO1, OPRD1, RAB3B, RIMBP2	290	synapse
GO:0032279	1.523e-03	0.101	3 CHRM1, CHRM3, GRIA3	5	asymmetric synapse
GO:0044463	1.573e-03	5.858	17 CHRM1, CHRM3, DRD1, DSCAM, FRMPD4, GRIA3, GRIN2B, HTR1A, HTR2A, MAPK1, NRSN1, NSF, OPRD1, PCSK1, ROBO2, SCN1A, SNTG1	290	cell projection part
GO:0030054	2.332e-03	8.525	21 CAMK2A, CBLN4, CHRM1, CHRM3, DNM2, DSG3, GABRA2, GABRA4, GAD2, GJD2, GLRA3, GRIA3, GRIK1, GRIN2B, KCTD16, LRFN2, NETO1, PANX1, PXN, RIMBP2, SCN1A	422	cell junction
GO:0042995	5.130e-03	12.52	26 CHRM1, CHRM3, DRD1, DSCAM, FRMPD4, GAD2, GRIA3, GRIN2B, HTR1A, HTR2A, KCNJ6, MAPK1, MTPN, NRSN1, NSF, OPRD1, PANX1, PCSK1, PEX5L, PXN, ROBO2, SACS, SCN1A, SEMA3A, SNTG1, TACR1	620	cell projection
GO:0043679	6.385e-03	0.6464	5 CHRM1, CHRM3, GRIA3, OPRD1, PCSK1	32	axon terminus
GO:0044306	6.385e-03	0.6464	5 CHRM1, CHRM3, GRIA3, OPRD1, PCSK1	32	neuron projection terminus
GO:0043025	8.015e-03	2.828	10 DRD1, GRIA3, HTR1A, KCNB2, KCNJ6, MAPK1, NRSN1, PCSK1, SCN1A, SST	140	neuronal cell body
GO:0044297	8.015e-03	2.828	10 DRD1, GRIA3, HTR1A, KCNB2, KCNJ6, MAPK1, NRSN1, PCSK1, SCN1A, SST	140	cell body
GO:0043083	1.548e-02	0.0606	2 GRIA3, GRIN2B	3	synaptic cleft
GO:0042734	1.607e-02	0.4848	4 CAMK2A, GAD2, GRIN2B, KCTD16	24	presynaptic membrane
GO:0043198	2.367e-02	0.2626	3 GRIA3, HTR2A, NSF	13	dendritic shaft

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022836	3.529e-11	4.988	28 CACNG3, GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SCN1A, SCN3A, SCN3B, TRPC5	247	gated channel activity
GO:0022843	6.864e-11	2.383	20 CACNG3, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SCN1A, SCN3A, SCN3B	118	voltage-gated cation channel activity
GO:0015267	1.136e-10	6.502	31 ANO3, CACNG3, GABRA2, GABRA4, GJD2, GLRA3, GRIA3, GRIK1, GRIN2B, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, PANX1, SCN1A, SCN3A, SCN3B, TRPC5	322	channel activity
GO:0022803	1.220e-10	6.523	31 ANO3, CACNG3, GABRA2, GABRA4, GJD2, GLRA3, GRIA3, GRIK1, GRIN2B, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, PANX1, SCN1A, SCN3A, SCN3B, TRPC5	323	passive transmembrane transporter activity
GO:0005216	5.133e-10	6.078	29 ANO3, CACNG3, GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SCN1A, SCN3A, SCN3B, TRPC5	301	ion channel activity
GO:0008227	1.017e-09	0.5856	11 ADRA1D, CHRM1, CHRM3, DRD1, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6	29	G-protein coupled amine receptor activity
GO:0005249	1.055e-09	1.636	16 KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4	81	voltage-gated potassium channel activity
GO:0022838	1.055e-09	6.28	29 ANO3, CACNG3, GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SCN1A, SCN3A, SCN3B, TRPC5	311	substrate-specific channel activity
GO:0005244	5.723e-09	3.11	20 CACNG3, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SCN1A, SCN3A, SCN3B	154	voltage-gated ion channel activity
GO:0022832	5.723e-09	3.11	20 CACNG3, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SCN1A, SCN3A, SCN3B	154	voltage-gated channel activity
GO:0005267	7.743e-09	2.181	17 KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4	108	potassium channel activity
GO:0005261	1.544e-08	4.463	23 CACNG3, GRIN2B, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SCN1A, SCN3A, SCN3B, TRPC5	221	cation channel activity
GO:0004930	5.212e-07	7.351	27 ADRA1D, CHRM1, CHRM3, DRD1, GPR149, GPR26, GPR83, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, MAS1, MC4R, MCHR2, NPY2R, OPRD1, P2RY12, RORB, RXFP1, RXFP3, TACR1, TRHR	364	G-protein coupled receptor activity
GO:0015075	9.592e-07	11.41	34 ANO3, ATP2B1, ATP6V1C1, CACNG3, GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SCN1A, SCN3A, SCN3B, SLC10A4, SLC39A10, SLC8A3, TRPC5	565	ion transmembrane transporter activity
GO:0004871	9.829e-07	27.14	58 ADCYAP1, ADRA1D, ARNTL2, CHRM1, CHRM3, DCLK1, DRD1, EPHA4, EPHA5, FLRT2, GABRA2, GABRA4, GLRA3, GPR149, GPR26, GPR83, GRIA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, IL1RAPL2, KCNH4, KCNH7, MAPK1, MAPK8, MAS1, MC4R, MCHR2, MMD, NDFIP1, NETO1, NLK, NPY2R, NRG3, OPRD1, P2RY12, PDE8B, PLCB1, PLXNA4, RGS4, ROBO2, RORB, RXFP1, RXFP3, SEMA3A, SHC3, TACR1, THRB, TRHR, UNC5D	1344	signal transducer activity
GO:0060089	9.829e-07	27.14	58 ADCYAP1, ADRA1D, ARNTL2, CHRM1, CHRM3, DCLK1, DRD1, EPHA4, EPHA5, FLRT2, GABRA2, GABRA4, GLRA3, GPR149, GPR26, GPR83, GRIA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, IL1RAPL2, KCNH4, KCNH7, MAPK1, MAPK8, MAS1, MC4R, MCHR2, MMD, NDFIP1, NETO1, NLK, NPY2R, NRG3, OPRD1, P2RY12, PDE8B, PLCB1, PLXNA4, RGS4, ROBO2, RORB, RXFP1, RXFP3, SEMA3A, SHC3, TACR1, THRB, TRHR, UNC5D	1344	molecular transducer activity
GO:0004888	3.010e-06	13.81	37 ADRA1D, CHRM1, CHRM3, DRD1, EPHA4, EPHA5, GABRA2, GABRA4, GPR149, GPR26, GPR83, GRIA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, IL1RAPL2, MAS1, MC4R, MCHR2, NPY2R, OPRD1, P2RY12, PLXNA4, ROBO2, RORB, RXFP1, RXFP3, TACR1, TRHR	684	transmembrane receptor activity
GO:0008324	5.181e-06	8.825	28 ATP2B1, ATP6V1C1, CACNG3, GRIN2B, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SCN1A, SCN3A, SCN3B, SLC10A4, SLC39A10, SLC8A3, TRPC5	437	cation transmembrane transporter activity
GO:0022857	7.681e-06	14.38	37 ANO3, ATP2B1, ATP6V1C1, CACNG3, GABRA2, GABRA4, GJD2, GLRA3, GRIA3, GRIK1, GRIN2B, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, PANX1, SCN1A, SCN3A, SCN3B, SLC10A4, SLC24A4, SLC39A10, SLC8A3, TRPC5	712	transmembrane transporter activity
GO:0042165	1.663e-05	1.171	10 CHRM1, CHRM3, GABRA2, GABRA4, GPR83, GRIN2B, GRPR, HCRTR2, NPY2R, TACR1	58	neurotransmitter binding
GO:0022891	2.050e-05	13.11	34 ANO3, ATP2B1, ATP6V1C1, CACNG3, GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SCN1A, SCN3A, SCN3B, SLC10A4, SLC39A10, SLC8A3, TRPC5	649	substrate-specific transmembrane transporter activity
GO:0030594	4.209e-05	1.01	9 CHRM1, CHRM3, GABRA2, GABRA4, GPR83, GRPR, HCRTR2, NPY2R, TACR1	50	neurotransmitter receptor activity
GO:0004872	7.460e-05	20.03	43 ADRA1D, CHRM1, CHRM3, DRD1, EPHA4, EPHA5, GABRA2, GABRA4, GLRA3, GPR149, GPR26, GPR83, GRIA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, IL1RAPL2, MAS1, MC4R, MCHR2, MMD, NETO1, NPY2R, OPRD1, P2RY12, PLXNA4, ROBO2, RORB, RXFP1, RXFP3, SEMA3A, TACR1, THRB, TRHR, UNC5D	992	receptor activity
GO:0004993	8.949e-05	0.2221	5 HTR1A, HTR1B, HTR2A, HTR2C, HTR4	11	serotonin receptor activity
GO:0005215	1.329e-04	18.42	40 ANO3, ATP2B1, ATP6V1C1, CACNG3, GABRA2, GABRA4, GJD2, GLRA3, GRIA3, GRIK1, GRIN2B, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, KLHL2, NGB, PANX1, SCN1A, SCN3A, SCN3B, SLC10A4, SLC24A4, SLC39A10, SLC8A3, SLCO1C1, TRPC5	912	transporter activity
GO:0022892	1.748e-04	15.23	35 ANO3, ATP2B1, ATP6V1C1, CACNG3, GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNH4, KCNH7, KCNJ6, KCNK2, KCNMB2, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, NGB, SCN1A, SCN3A, SCN3B, SLC10A4, SLC39A10, SLC8A3, TRPC5	754	substrate-specific transporter activity
GO:0051378	3.050e-04	0.1414	4 HTR1A, HTR1B, HTR2A, HTR2C	7	serotonin binding
GO:0008144	1.315e-03	0.9087	7 CHRM1, CHRM3, DRD1, HTR1A, HTR1B, HTR2A, HTR2C	45	drug binding
GO:0042923	1.362e-03	0.626	6 GPR83, GRPR, HCRTR2, MC4R, NPY2R, TACR1	31	neuropeptide binding
GO:0015276	1.441e-03	2.019	10 GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B, KCNH7, KCNJ6, KCNQ5, TRPC5	100	ligand-gated ion channel activity
GO:0022834	1.441e-03	2.019	10 GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B, KCNH7, KCNJ6, KCNQ5, TRPC5	100	ligand-gated channel activity
GO:0001653	1.671e-03	1.656	9 GPR83, GRPR, HCRTR2, MAS1, MC4R, NPY2R, OPRD1, RXFP3, TACR1	82	peptide receptor activity
GO:0008528	1.671e-03	1.656	9 GPR83, GRPR, HCRTR2, MAS1, MC4R, NPY2R, OPRD1, RXFP3, TACR1	82	peptide receptor activity, G-protein coupled
GO:0004434	4.402e-03	0.5048	5 CHRM1, CHRM3, HTR2A, HTR2C, PLCB1	25	inositol or phosphatidylinositol phosphodiesterase activity
GO:0004435	4.402e-03	0.5048	5 CHRM1, CHRM3, HTR2A, HTR2C, PLCB1	25	phosphoinositide phospholipase C activity
GO:0004629	8.051e-03	0.5856	5 CHRM1, CHRM3, HTR2A, HTR2C, PLCB1	29	phospholipase C activity
GO:0008188	9.179e-03	0.6058	5 GPR83, GRPR, HCRTR2, NPY2R, TACR1	30	neuropeptide receptor activity
GO:0005184	9.420e-03	0.3433	4 ADCYAP1, CRH, PNOC, VIP	17	neuropeptide hormone activity
GO:0043176	1.132e-02	1.777	8 CHRM1, CHRM3, DRD1, GRIN2B, HTR1A, HTR1B, HTR2A, HTR2C	88	amine binding
GO:0005251	1.637e-02	0.1817	3 KCNA3, KCNB2, KCNS1	9	delayed rectifier potassium channel activity
GO:0008081	1.929e-02	1.515	7 CHRM1, CHRM3, HTR2A, HTR2C, PDE7B, PDE8B, PLCB1	75	phosphoric diester hydrolase activity
GO:0004707	2.138e-02	0.2019	3 MAPK1, MAPK8, NLK	10	MAP kinase activity
GO:0042277	2.393e-02	3.069	10 GPR83, GRPR, HCRTR2, MAS1, MC4R, NPY2R, OPRD1, PCSK1, RXFP3, TACR1	152	peptide binding
GO:0005230	2.474e-02	1.171	6 GABRA2, GABRA4, GLRA3, GRIA3, GRIK1, GRIN2B	58	extracellular ligand-gated ion channel activity
GO:0004981	2.697e-02	0.06058	2 CHRM1, CHRM3	3	muscarinic acetylcholine receptor activity
GO:0016907	2.697e-02	0.06058	2 CHRM1, CHRM3	3	G-protein coupled acetylcholine receptor activity
GO:0017046	3.106e-02	0.5048	4 HCRTR2, MAS1, MC4R, PCSK1	25	peptide hormone binding
GO:0001515	4.490e-02	0.08077	2 PDYN, PNOC	4	opioid peptide activity
GO:0008503	4.490e-02	0.08077	2 GABRA2, GABRA4	4	benzodiazepine receptor activity
GO:0005248	4.684e-02	0.2827	3 SCN1A, SCN3A, SCN3B	14	voltage-gated sodium channel activity

Id	Pvalue	ExpCount	Count	Size	Term
04080	2.367e-14	4.404	29 ADRA1D, CHRM1, CHRM3, DRD1, GABRA2, GABRA4, GLRA3, GPR83, GRIA3, GRIK1, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR2A, HTR2C, HTR4, HTR6, MAS1, MC4R, MCHR2, NPY2R, OPRD1, RXFP1, TACR1, THRB, TRHR	206	Neuroactive ligand-receptor interaction
04020	2.769e-06	3.1	16 ADRA1D, ATP2B1, CAMK2A, CHRM1, CHRM3, DRD1, GRPR, HRH1, HTR2A, HTR2C, HTR4, HTR6, PLCB1, SLC8A3, TACR1, TRHR	145	Calcium signaling pathway
04540	5.894e-03	1.261	7 DRD1, GJD2, HTR2A, HTR2C, MAPK1, PLCB1, PRKG2	59	Gap junction
04360	3.112e-02	2.266	8 EPHA4, EPHA5, LRRC4C, MAPK1, ROBO2, SEMA3A, SLIT1, UNC5D	106	Axon guidance

No enriched terms

No enriched terms

Entrez genes

ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary) (ENSG00000141433), score: 0.75 ADRA1Dadrenergic, alpha-1D-, receptor (ENSG00000171873), score: 0.74 AGBL4ATP/GTP binding protein-like 4 (ENSG00000186094), score: 0.7 AK5adenylate kinase 5 (ENSG00000154027), score: 0.74 AKAP11A kinase (PRKA) anchor protein 11 (ENSG00000023516), score: 0.72 ANO3anoctamin 3 (ENSG00000134343), score: 0.84 ARNTL2aryl hydrocarbon receptor nuclear translocator-like 2 (ENSG00000029153), score: 0.75 ATP2B1ATPase, Ca++ transporting, plasma membrane 1 (ENSG00000070961), score: 0.74 ATP6V1C1ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 (ENSG00000155097), score: 0.72 ATRNL1attractin-like 1 (ENSG00000107518), score: 0.78 B3GALT1UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 (ENSG00000172318), score: 0.82 BCAT1branched chain amino-acid transaminase 1, cytosolic (ENSG00000060982), score: 0.7 BCL11AB-cell CLL/lymphoma 11A (zinc finger protein) (ENSG00000119866), score: 0.7 BCL11BB-cell CLL/lymphoma 11B (zinc finger protein) (ENSG00000127152), score: 0.75 BTBD9BTB (POZ) domain containing 9 (ENSG00000183826), score: 0.78 C11orf87chromosome 11 open reading frame 87 (ENSG00000185742), score: 0.75 C13orf36chromosome 13 open reading frame 36 (ENSG00000180440), score: 0.87 C2orf80chromosome 2 open reading frame 80 (ENSG00000188674), score: 0.73 C8orf46chromosome 8 open reading frame 46 (ENSG00000169085), score: 0.7 CACNG3calcium channel, voltage-dependent, gamma subunit 3 (ENSG00000006116), score: 0.8 CAMK2Acalcium/calmodulin-dependent protein kinase II alpha (ENSG00000070808), score: 0.72 CBLN2cerebellin 2 precursor (ENSG00000141668), score: 0.75 CBLN4cerebellin 4 precursor (ENSG00000054803), score: 0.85 CDC40cell division cycle 40 homolog (S. cerevisiae) (ENSG00000168438), score: 0.71 CDC42SE2CDC42 small effector 2 (ENSG00000158985), score: 0.7 CDH12cadherin 12, type 2 (N-cadherin 2) (ENSG00000154162), score: 0.84 CDH8cadherin 8, type 2 (ENSG00000150394), score: 0.91 CDH9cadherin 9, type 2 (T1-cadherin) (ENSG00000113100), score: 0.87 CDKL5cyclin-dependent kinase-like 5 (ENSG00000008086), score: 0.76 CHRM1cholinergic receptor, muscarinic 1 (ENSG00000168539), score: 0.72 CHRM3cholinergic receptor, muscarinic 3 (ENSG00000133019), score: 0.86 CHSY3chondroitin sulfate synthase 3 (ENSG00000198108), score: 0.74 CNTN3contactin 3 (plasmacytoma associated) (ENSG00000113805), score: 0.9 CNTN5contactin 5 (ENSG00000149972), score: 0.82 CNTNAP5contactin associated protein-like 5 (ENSG00000155052), score: 0.88 COL11A1collagen, type XI, alpha 1 (ENSG00000060718), score: 0.72 CREG2cellular repressor of E1A-stimulated genes 2 (ENSG00000175874), score: 0.74 CRHcorticotropin releasing hormone (ENSG00000147571), score: 0.84 CSMD3CUB and Sushi multiple domains 3 (ENSG00000164796), score: 0.86 CSRNP3cysteine-serine-rich nuclear protein 3 (ENSG00000178662), score: 0.92 DCLK1doublecortin-like kinase 1 (ENSG00000133083), score: 0.72 DCXdoublecortin (ENSG00000077279), score: 0.79 DGKBdiacylglycerol kinase, beta 90kDa (ENSG00000136267), score: 0.85 DGKIdiacylglycerol kinase, iota (ENSG00000157680), score: 0.81 DLX1distal-less homeobox 1 (ENSG00000144355), score: 0.81 DLX2distal-less homeobox 2 (ENSG00000115844), score: 0.71 DNM2dynamin 2 (ENSG00000079805), score: -0.72 DOK6docking protein 6 (ENSG00000206052), score: 0.71 DPP10dipeptidyl-peptidase 10 (non-functional) (ENSG00000175497), score: 0.79 DRD1dopamine receptor D1 (ENSG00000184845), score: 0.72 DRP2dystrophin related protein 2 (ENSG00000102385), score: 0.74 DSCAMDown syndrome cell adhesion molecule (ENSG00000171587), score: 0.72 DSG3desmoglein 3 (ENSG00000134757), score: 0.74 EGR3early growth response 3 (ENSG00000179388), score: 0.7 ENC1ectodermal-neural cortex 1 (with BTB-like domain) (ENSG00000171617), score: 0.77 EPHA4EPH receptor A4 (ENSG00000116106), score: 0.75 EPHA5EPH receptor A5 (ENSG00000145242), score: 0.85 EPHX4epoxide hydrolase 4 (ENSG00000172031), score: 0.76 ETV5ets variant 5 (ENSG00000244405), score: 0.72 FAM122Bfamily with sequence similarity 122B (ENSG00000156504), score: 0.7 FAM19A1family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 (ENSG00000183662), score: 0.86 FAM19A2family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 (ENSG00000198673), score: 0.85 FAM49Afamily with sequence similarity 49, member A (ENSG00000197872), score: 0.78 FAM5Bfamily with sequence similarity 5, member B (ENSG00000198797), score: 0.7 FAM5Cfamily with sequence similarity 5, member C (ENSG00000162670), score: 0.72 FAM92Bfamily with sequence similarity 92, member B (ENSG00000153789), score: 0.73 FAR2fatty acyl CoA reductase 2 (ENSG00000064763), score: 0.78 FAT3FAT tumor suppressor homolog 3 (Drosophila) (ENSG00000165323), score: 0.73 FERD3LFer3-like (Drosophila) (ENSG00000146618), score: 0.88 FGF10fibroblast growth factor 10 (ENSG00000070193), score: 0.92 FLRT2fibronectin leucine rich transmembrane protein 2 (ENSG00000185070), score: 0.79 FOXP2forkhead box P2 (ENSG00000128573), score: 0.75 FREM3FRAS1 related extracellular matrix 3 (ENSG00000183090), score: 0.74 FRMPD4FERM and PDZ domain containing 4 (ENSG00000169933), score: 0.78 GABRA2gamma-aminobutyric acid (GABA) A receptor, alpha 2 (ENSG00000151834), score: 0.72 GABRA4gamma-aminobutyric acid (GABA) A receptor, alpha 4 (ENSG00000109158), score: 0.92 GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (ENSG00000136750), score: 0.71 GALNTL6UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6 (ENSG00000174473), score: 0.83 GJD2gap junction protein, delta 2, 36kDa (ENSG00000159248), score: 0.8 GLRA3glycine receptor, alpha 3 (ENSG00000145451), score: 1 GPR149G protein-coupled receptor 149 (ENSG00000174948), score: 0.78 GPR26G protein-coupled receptor 26 (ENSG00000154478), score: 0.85 GPR83G protein-coupled receptor 83 (ENSG00000123901), score: 0.76 GRIA3glutamate receptor, ionotrophic, AMPA 3 (ENSG00000125675), score: 0.74 GRIK1glutamate receptor, ionotropic, kainate 1 (ENSG00000171189), score: 0.75 GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B (ENSG00000150086), score: 0.81 GTDC1glycosyltransferase-like domain containing 1 (ENSG00000121964), score: 0.7 HAPLN1hyaluronan and proteoglycan link protein 1 (ENSG00000145681), score: 0.71 HCRTR2hypocretin (orexin) receptor 2 (ENSG00000137252), score: 0.73 HN1Lhematological and neurological expressed 1-like (ENSG00000206053), score: -0.7 HOPXHOP homeobox (ENSG00000171476), score: 0.7 HRH1histamine receptor H1 (ENSG00000196639), score: 0.82 HTR1A5-hydroxytryptamine (serotonin) receptor 1A (ENSG00000178394), score: 0.8 HTR1B5-hydroxytryptamine (serotonin) receptor 1B (ENSG00000135312), score: 0.79 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (ENSG00000102468), score: 0.86 HTR2C5-hydroxytryptamine (serotonin) receptor 2C (ENSG00000147246), score: 0.85 HTR45-hydroxytryptamine (serotonin) receptor 4 (ENSG00000164270), score: 0.85 HTR65-hydroxytryptamine (serotonin) receptor 6 (ENSG00000158748), score: 0.87 IL1RAPL2interleukin 1 receptor accessory protein-like 2 (ENSG00000189108), score: 0.75 INSM2insulinoma-associated 2 (ENSG00000168348), score: 0.72 KAL1Kallmann syndrome 1 sequence (ENSG00000011201), score: 0.79 KCNA3potassium voltage-gated channel, shaker-related subfamily, member 3 (ENSG00000177272), score: 0.76 KCNA4potassium voltage-gated channel, shaker-related subfamily, member 4 (ENSG00000182255), score: 0.86 KCNA6potassium voltage-gated channel, shaker-related subfamily, member 6 (ENSG00000151079), score: 0.76 KCNB2potassium voltage-gated channel, Shab-related subfamily, member 2 (ENSG00000182674), score: 0.88 KCNC2potassium voltage-gated channel, Shaw-related subfamily, member 2 (ENSG00000166006), score: 0.8 KCNH4potassium voltage-gated channel, subfamily H (eag-related), member 4 (ENSG00000089558), score: 0.82 KCNH7potassium voltage-gated channel, subfamily H (eag-related), member 7 (ENSG00000184611), score: 0.91 KCNJ6potassium inwardly-rectifying channel, subfamily J, member 6 (ENSG00000157542), score: 0.71 KCNK2potassium channel, subfamily K, member 2 (ENSG00000082482), score: 0.76 KCNMB2potassium large conductance calcium-activated channel, subfamily M, beta member 2 (ENSG00000197584), score: 0.8 KCNQ3potassium voltage-gated channel, KQT-like subfamily, member 3 (ENSG00000184156), score: 0.77 KCNQ5potassium voltage-gated channel, KQT-like subfamily, member 5 (ENSG00000185760), score: 0.83 KCNS1potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 (ENSG00000124134), score: 0.82 KCNS2potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 (ENSG00000156486), score: 0.85 KCNV1potassium channel, subfamily V, member 1 (ENSG00000164794), score: 0.83 KCTD16potassium channel tetramerisation domain containing 16 (ENSG00000183775), score: 0.83 KCTD4potassium channel tetramerisation domain containing 4 (ENSG00000180332), score: 0.8 KIAA0748KIAA0748 (ENSG00000135426), score: 0.79 KIAA2022KIAA2022 (ENSG00000050030), score: 0.83 KLHL2kelch-like 2, Mayven (Drosophila) (ENSG00000109466), score: 0.73 LINGO2leucine rich repeat and Ig domain containing 2 (ENSG00000174482), score: 0.71 LMNAlamin A/C (ENSG00000160789), score: -0.69 LMO4LIM domain only 4 (ENSG00000143013), score: 0.75 LMTK2lemur tyrosine kinase 2 (ENSG00000164715), score: 0.7 LNX1ligand of numb-protein X 1 (ENSG00000072201), score: 0.7 LOC100293130similar to kruppel-related zinc finger protein hcKrox (ENSG00000160685), score: -0.7 LOC100293905similar to gastrin-releasing peptide receptor (ENSG00000126010), score: 0.94 LPPR4lipid phosphate phosphatase-related protein type 4 (ENSG00000117600), score: 0.78 LPPR5lipid phosphate phosphatase-related protein type 5 (ENSG00000117598), score: 0.82 LRFN2leucine rich repeat and fibronectin type III domain containing 2 (ENSG00000156564), score: 0.69 LRFN5leucine rich repeat and fibronectin type III domain containing 5 (ENSG00000165379), score: 0.77 LRRC4Cleucine rich repeat containing 4C (ENSG00000148948), score: 0.73 LRRC55leucine rich repeat containing 55 (ENSG00000183908), score: 0.82 LRRC7leucine rich repeat containing 7 (ENSG00000033122), score: 0.74 LRRC8Bleucine rich repeat containing 8 family, member B (ENSG00000197147), score: 0.72 LRTM2leucine-rich repeats and transmembrane domains 2 (ENSG00000166159), score: 0.75 MAP2K4mitogen-activated protein kinase kinase 4 (ENSG00000065559), score: 0.74 MAPK1mitogen-activated protein kinase 1 (ENSG00000100030), score: 0.72 MAPK8mitogen-activated protein kinase 8 (ENSG00000107643), score: 0.76 MARCH1membrane-associated ring finger (C3HC4) 1 (ENSG00000145416), score: 0.7 MAS1MAS1 oncogene (ENSG00000130368), score: 0.92 MC4Rmelanocortin 4 receptor (ENSG00000166603), score: 0.75 MCHR2melanin-concentrating hormone receptor 2 (ENSG00000152034), score: 0.7 MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2 (ENSG00000139915), score: 0.84 MEF2Cmyocyte enhancer factor 2C (ENSG00000081189), score: 0.76 MEPEmatrix extracellular phosphoglycoprotein (ENSG00000152595), score: 0.83 MKL2MKL/myocardin-like 2 (ENSG00000186260), score: 0.81 MKNK2MAP kinase interacting serine/threonine kinase 2 (ENSG00000099875), score: -0.69 MMDmonocyte to macrophage differentiation-associated (ENSG00000108960), score: 0.71 MMP16matrix metallopeptidase 16 (membrane-inserted) (ENSG00000156103), score: 0.78 MTPNmyotrophin (ENSG00000105887), score: 0.73 NAPGN-ethylmaleimide-sensitive factor attachment protein, gamma (ENSG00000134265), score: 0.73 NCALDneurocalcin delta (ENSG00000104490), score: 0.77 NDFIP1Nedd4 family interacting protein 1 (ENSG00000131507), score: 0.7 NECAB1N-terminal EF-hand calcium binding protein 1 (ENSG00000123119), score: 0.81 NETO1neuropilin (NRP) and tolloid (TLL)-like 1 (ENSG00000166342), score: 0.87 NEUROD6neurogenic differentiation 6 (ENSG00000164600), score: 0.79 NGBneuroglobin (ENSG00000165553), score: 0.72 NLKnemo-like kinase (ENSG00000087095), score: 0.83 NPEPL1aminopeptidase-like 1 (ENSG00000215440), score: -0.79 NPY2Rneuropeptide Y receptor Y2 (ENSG00000185149), score: 0.88 NRG3neuregulin 3 (ENSG00000185737), score: 0.81 NRSN1neurensin 1 (ENSG00000152954), score: 0.71 NSFN-ethylmaleimide-sensitive factor (ENSG00000073969), score: 0.7 OPRD1opioid receptor, delta 1 (ENSG00000116329), score: 0.81 OSTNosteocrin (ENSG00000188729), score: 0.83 P2RY12purinergic receptor P2Y, G-protein coupled, 12 (ENSG00000169313), score: 0.72 PANX1pannexin 1 (ENSG00000110218), score: 0.73 PCDH19protocadherin 19 (ENSG00000165194), score: 0.85 PCDH20protocadherin 20 (ENSG00000197991), score: 0.82 PCDH8protocadherin 8 (ENSG00000136099), score: 0.74 PCSK1proprotein convertase subtilisin/kexin type 1 (ENSG00000175426), score: 0.87 PDE7Bphosphodiesterase 7B (ENSG00000171408), score: 0.71 PDE8Bphosphodiesterase 8B (ENSG00000113231), score: 0.75 PDS5BPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) (ENSG00000083642), score: 0.72 PDYNprodynorphin (ENSG00000101327), score: 0.87 PEX5Lperoxisomal biogenesis factor 5-like (ENSG00000114757), score: 0.75 PGM2L1phosphoglucomutase 2-like 1 (ENSG00000165434), score: 0.76 PLCB1phospholipase C, beta 1 (phosphoinositide-specific) (ENSG00000182621), score: 0.82 PLXNA4plexin A4 (ENSG00000221866), score: 0.73 PNOCprepronociceptin (ENSG00000168081), score: 0.78 PRICKLE2prickle homolog 2 (Drosophila) (ENSG00000163637), score: 0.74 PRKG2protein kinase, cGMP-dependent, type II (ENSG00000138669), score: 0.98 PRRG3proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) (ENSG00000130032), score: 0.78 PXNpaxillin (ENSG00000089159), score: -0.72 RAB3BRAB3B, member RAS oncogene family (ENSG00000169213), score: 0.75 RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian) (ENSG00000173039), score: -0.69 RGS4regulator of G-protein signaling 4 (ENSG00000117152), score: 0.81 RIMBP2RIMS binding protein 2 (ENSG00000060709), score: 0.71 RNF11ring finger protein 11 (ENSG00000123091), score: 0.72 RNF24ring finger protein 24 (ENSG00000101236), score: 0.71 ROBO2roundabout, axon guidance receptor, homolog 2 (Drosophila) (ENSG00000185008), score: 0.7 RORBRAR-related orphan receptor B (ENSG00000198963), score: 0.83 RSPO2R-spondin 2 homolog (Xenopus laevis) (ENSG00000147655), score: 0.78 RXFP1relaxin/insulin-like family peptide receptor 1 (ENSG00000171509), score: 0.72 RXFP3relaxin/insulin-like family peptide receptor 3 (ENSG00000182631), score: 0.95 SACSspastic ataxia of Charlevoix-Saguenay (sacsin) (ENSG00000151835), score: 0.7 SATB1SATB homeobox 1 (ENSG00000182568), score: 0.7 SATB2SATB homeobox 2 (ENSG00000119042), score: 0.76 SBNO2strawberry notch homolog 2 (Drosophila) (ENSG00000064932), score: -0.69 SCG2secretogranin II (ENSG00000171951), score: 0.75 SCN1Asodium channel, voltage-gated, type I, alpha subunit (ENSG00000144285), score: 0.7 SCN3Asodium channel, voltage-gated, type III, alpha subunit (ENSG00000153253), score: 0.76 SCN3Bsodium channel, voltage-gated, type III, beta (ENSG00000166257), score: 0.72 SEMA3Asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A (ENSG00000075213), score: 0.84 SERPINI1serpin peptidase inhibitor, clade I (neuroserpin), member 1 (ENSG00000163536), score: 0.72 SGTBsmall glutamine-rich tetratricopeptide repeat (TPR)-containing, beta (ENSG00000197860), score: 0.78 SH2D4BSH2 domain containing 4B (ENSG00000178217), score: 0.74 SH2D5SH2 domain containing 5 (ENSG00000189410), score: 0.7 SHC3SHC (Src homology 2 domain containing) transforming protein 3 (ENSG00000148082), score: 0.82 SLC10A4solute carrier family 10 (sodium/bile acid cotransporter family), member 4 (ENSG00000145248), score: 0.73 SLC24A4solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 (ENSG00000140090), score: 0.77 SLC35F1solute carrier family 35, member F1 (ENSG00000196376), score: 0.71 SLC39A10solute carrier family 39 (zinc transporter), member 10 (ENSG00000196950), score: 0.78 SLC8A3solute carrier family 8 (sodium/calcium exchanger), member 3 (ENSG00000100678), score: 0.72 SLCO1C1solute carrier organic anion transporter family, member 1C1 (ENSG00000139155), score: 0.72 SLIT1slit homolog 1 (Drosophila) (ENSG00000187122), score: 0.73 SLITRK1SLIT and NTRK-like family, member 1 (ENSG00000178235), score: 0.76 SLITRK2SLIT and NTRK-like family, member 2 (ENSG00000185985), score: 0.7 SLITRK5SLIT and NTRK-like family, member 5 (ENSG00000165300), score: 0.71 SMARCD2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 (ENSG00000108604), score: -0.72 SNTG1syntrophin, gamma 1 (ENSG00000147481), score: 0.78 SPIN1spindlin 1 (ENSG00000106723), score: 0.79 SSTsomatostatin (ENSG00000157005), score: 0.73 ST6GALNAC5ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ENSG00000117069), score: 0.8 STAU2staufen, RNA binding protein, homolog 2 (Drosophila) (ENSG00000040341), score: 0.7 STYK1serine/threonine/tyrosine kinase 1 (ENSG00000060140), score: 0.86 SYNJ1synaptojanin 1 (ENSG00000159082), score: 0.71 TACR1tachykinin receptor 1 (ENSG00000115353), score: 0.7 TBR1T-box, brain, 1 (ENSG00000136535), score: 0.76 THRBthyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) (ENSG00000151090), score: 0.73 TMEM132Dtransmembrane protein 132D (ENSG00000151952), score: 0.85 TMEM155transmembrane protein 155 (ENSG00000164112), score: 0.81 TMEM196transmembrane protein 196 (ENSG00000173452), score: 0.85 TMEM200Atransmembrane protein 200A (ENSG00000164484), score: 0.76 TRABDTraB domain containing (ENSG00000170638), score: -0.74 TRHRthyrotropin-releasing hormone receptor (ENSG00000174417), score: 0.9 TRPC5transient receptor potential cation channel, subfamily C, member 5 (ENSG00000072315), score: 0.87 TSHZ3teashirt zinc finger homeobox 3 (ENSG00000121297), score: 0.72 UNC5Dunc-5 homolog D (C. elegans) (ENSG00000156687), score: 0.8 VIPvasoactive intestinal peptide (ENSG00000146469), score: 0.87 VSTM2AV-set and transmembrane domain containing 2A (ENSG00000170419), score: 0.83 VWC2Lvon Willebrand factor C domain-containing protein 2-like (ENSG00000174453), score: 0.94 WDR7WD repeat domain 7 (ENSG00000091157), score: 0.73 XKR4XK, Kell blood group complex subunit-related family, member 4 (ENSG00000206579), score: 0.76 ZC3H12Bzinc finger CCCH-type containing 12B (ENSG00000102053), score: 0.75 ZMAT3zinc finger, matrin type 3 (ENSG00000172667), score: 0.71 ZMAT4zinc finger, matrin type 4 (ENSG00000165061), score: 0.72 ZNF804Bzinc finger protein 804B (ENSG00000182348), score: 0.78 ZNF831zinc finger protein 831 (ENSG00000124203), score: 0.81

Non-Entrez genes

ENSG00000141668Unknown, score: 0.81 ENSG00000054803Unknown, score: 0.75

Id	species	tissue	sex	individual
ggo_br_f_ca1	ggo	br	f	_
ppy_br_f_ca1	ppy	br	f	_
hsa_br_m2_ca1	hsa	br	m	2
ptr_br_m4_ca1	ptr	br	m	4
ppy_br_m_ca1	ppy	br	m	_
ppa_br_m_ca1	ppa	br	m	_
mml_br_f_ca1	mml	br	f	_
mml_br_m1_ca1	mml	br	m	1
mml_br_m2_ca1	mml	br	m	2