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skeletal system development

The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

regionalization

The pattern specification process by which an axis or axes is subdivided in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

anion transport

The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

embryo development

The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.

pattern specification process

Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

embryo development ending in birth or egg hatching

The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.

anterior/posterior pattern formation

The regionalization process by which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

inorganic anion transport

The directed movement of inorganic anions into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.

thyroid gland development

The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

endocrine system development

Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.

homeostatic process

Any biological process involved in the maintenance of an internal steady-state.

chordate embryonic development

The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.

ion homeostasis

Any process involved in the maintenance of an internal steady-state of ions within an organism or cell.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ morphogenesis

Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ development

Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic morphogenesis

The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.

embryonic skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form.

skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized. Morphogenesis pertains to the creation of form.

embryonic skeletal system development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

gland development

The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

chemical homeostasis

Any biological process involved in the maintenance of an internal steady-state of a chemical.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

di-, tri-valent inorganic anion homeostasis

Any process involved in the maintenance of an internal steady-state of divalent or trivalent inorganic anions within an organism or cell.

phosphate ion homeostasis

Any process involved in the maintenance of an internal steady-state of phosphate ions within an organism or cell.

anion homeostasis

Any process involved in the maintenance of an internal steady-state of anions within an organism or cell.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

all

NA

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

embryo development

The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.

pattern specification process

Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

embryonic morphogenesis

The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ morphogenesis

Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ morphogenesis

Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ development

Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized. Morphogenesis pertains to the creation of form.

embryonic skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form.

embryonic skeletal system development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.

thyroid gland development

The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.

embryonic skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

brush border

Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

organelle membrane

The lipid bilayer surrounding an organelle.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

nucleic acid binding

Interacting selectively and non-covalently with any nucleic acid.

DNA binding

Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).

sequence-specific DNA binding transcription factor activity

Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

secondary active transmembrane transporter activity

Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.

inorganic anion exchanger activity

NA

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

cytoskeletal protein binding

Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

anion transmembrane transporter activity

Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

inorganic anion transmembrane transporter activity

Catalysis of the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.

phosphate transmembrane transporter activity

Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other.

symporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

solute:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).

anion:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in).

antiporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

solute:solute antiporter activity

Catalysis of the reaction: solute A(out) + solute B(in) = solute A(in) + solute B(out).

anion:anion antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).

sodium-dependent phosphate transmembrane transporter activity

Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions.

anion exchanger activity

NA

active transmembrane transporter activity

Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ankyrin binding

Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.

sequence-specific DNA binding

Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

solute:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).

anion:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in).

anion:anion antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).

Id	Pvalue	ExpCount	Count	Size	Term
GO:0048706	1.836e-07	1.126	12 HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC6, HOXD1, HOXD10, HOXD3, HOXD4, HOXD9, MDFI	69	embryonic skeletal system development
GO:0048562	5.058e-07	1.811	14 CRYAA, FOXI1, HMX2, HMX3, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXD10, HOXD3, HOXD4, HOXD9, MDFI	111	embryonic organ morphogenesis
GO:0001501	5.865e-07	3.638	19 BARX2, CLEC3A, HOXA10, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC10, HOXC6, HOXC8, HOXD1, HOXD10, HOXD3, HOXD4, HOXD9, IL17F, MDFI, TCOF1	223	skeletal system development
GO:0048704	6.543e-07	0.783	10 HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXD10, HOXD3, HOXD4, HOXD9, MDFI	48	embryonic skeletal system morphogenesis
GO:0009952	8.562e-07	1.892	14 CER1, HOXA10, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC10, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD9	116	anterior/posterior pattern formation
GO:0003002	3.738e-06	2.887	16 CER1, HOXA10, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC10, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD9, LMX1B, MDFI	177	regionalization
GO:0048705	6.441e-06	1.582	12 BARX2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC8, HOXD10, HOXD3, HOXD4, HOXD9, MDFI	97	skeletal system morphogenesis
GO:0009653	7.261e-06	17.01	41 AQP6, BARX2, CER1, COL4A3, CRYAA, FOXI1, GATA3, GZF1, HMX2, HMX3, HOXA10, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC10, HOXC8, HOXD10, HOXD3, HOXD4, HOXD9, IL17F, IL18, ITGB3, KLK3, LMX1B, MDFI, NOX4, ODAM, PAX2, PAX8, PKHD1, PLA2G10, PODXL, SFTPB, TBX2, TFCP2L1, TINAG, VCAM1, ZC3H12A	1043	anatomical structure morphogenesis
GO:0048598	1.287e-05	4.502	19 CER1, CRYAA, FOXI1, HMX2, HMX3, HOXA10, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC10, HOXD10, HOXD3, HOXD4, HOXD9, MDFI, TINAG, VCAM1	276	embryonic morphogenesis
GO:0048568	1.736e-05	2.855	15 CRYAA, FOXI1, HMX2, HMX3, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXD10, HOXD3, HOXD4, HOXD9, MDFI, VCAM1	175	embryonic organ development
GO:0032501	7.083e-05	53.83	84 AGTR2, AQP6, ATP6V0A4, ATP6V1B1, BARX2, BFSP2, CALCA, CDH3, CER1, CLCNKA, CLEC3A, COL4A3, COL4A4, CRYAA, CYP27B1, DMRT2, ELF5, EVPL, F2RL1, FOXI1, GZF1, HELT, HMX2, HMX3, HOXA10, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB7, HOXC10, HOXC6, HOXC8, HOXC9, HOXD1, HOXD10, HOXD3, HOXD4, HOXD9, HSD11B2, IL17F, IL18, IMPG1, INSRR, ITGB3, KCNJ1, KLK3, LMX1B, MDFI, MMP1, MMP7, NOX4, NPHS2, NPNT, ODAM, OR51E2, PAX2, PAX8, PKHD1, PLA2G10, PLCG2, PODXL, PRR15, RHCG, SCIN, SCNN1A, SFTPB, SH2B2, SIM2, SLC34A1, SLC34A2, SLC45A2, SOST, TACSTD2, TBX2, TCOF1, TFCP2L1, TINAG, TSPAN2, TSPAN8, VCAM1, WFDC2, ZC3H12A	3300	multicellular organismal process
GO:0007389	7.385e-05	3.687	16 CER1, HOXA10, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC10, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD9, LMX1B, MDFI	226	pattern specification process
GO:0006811	2.211e-04	10.82	28 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSPRY, CALCA, CLCNKA, CYP27B1, FXYD2, GABRP, KCNJ1, LTF, PLCG2, RHAG, RHCG, SCNN1A, SLC12A1, SLC12A3, SLC22A11, SLC22A12, SLC24A6, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11, WNK4	663	ion transport
GO:0006820	3.073e-04	1.256	9 SLC22A11, SLC22A12, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11, WNK4	77	anion transport
GO:0048731	3.502e-04	32.5	57 AGTR2, AQP6, BARX2, CALCA, CLEC3A, COL4A3, COL4A4, CRYAA, CYP27B1, DMRT2, ELF5, EVPL, FOXI1, GZF1, HELT, HMX2, HMX3, HOXA10, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC10, HOXC6, HOXC8, HOXD1, HOXD10, HOXD3, HOXD4, HOXD9, IL17F, IL18, ITGB3, KLK3, LMX1B, MDFI, NOX4, ODAM, PAX2, PAX8, PKHD1, PLA2G10, PLCG2, PODXL, RHCG, SCIN, SFTPB, SH2B2, SIM2, TBX2, TCOF1, TFCP2L1, TINAG, TSPAN2, VCAM1, ZC3H12A	1992	system development
GO:0009790	5.444e-04	8.287	23 CER1, CRYAA, FOXI1, HMX2, HMX3, HOXA10, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC10, HOXC6, HOXD1, HOXD10, HOXD3, HOXD4, HOXD9, LMX1B, MDFI, SLC34A2, TINAG, VCAM1	508	embryo development
GO:0032502	5.605e-04	42.35	68 AGTR2, AQP6, BARX2, CALCA, CER1, CLEC3A, COL4A3, COL4A4, CRYAA, CYP27B1, DMRT2, ELF5, EVPL, FOXI1, GATA3, GZF1, HELT, HMX2, HMX3, HOXA10, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB7, HOXC10, HOXC6, HOXC8, HOXC9, HOXD1, HOXD10, HOXD3, HOXD4, HOXD9, IL17F, IL18, INSRR, ITGB3, KLK3, LMX1B, MDFI, NOX4, NPNT, ODAM, PAPPA, PAX2, PAX8, PKHD1, PLA2G10, PLCG2, PODXL, PRR15, PTPRQ, RHCG, SCIN, SFTPB, SH2B2, SIM2, SLC34A2, SLC45A2, TBX2, TCOF1, TFCP2L1, TINAG, TSPAN2, VCAM1, ZC3H12A	2596	developmental process
GO:0007275	5.656e-04	38.92	64 AGTR2, AQP6, BARX2, CALCA, CER1, CLEC3A, COL4A3, COL4A4, CRYAA, CYP27B1, DMRT2, ELF5, EVPL, FOXI1, GZF1, HELT, HMX2, HMX3, HOXA10, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB7, HOXC10, HOXC6, HOXC8, HOXC9, HOXD1, HOXD10, HOXD3, HOXD4, HOXD9, IL17F, IL18, INSRR, ITGB3, KLK3, LMX1B, MDFI, NOX4, NPNT, ODAM, PAX2, PAX8, PKHD1, PLA2G10, PLCG2, PODXL, PRR15, RHCG, SCIN, SFTPB, SH2B2, SIM2, SLC34A2, TBX2, TCOF1, TFCP2L1, TINAG, TSPAN2, VCAM1, ZC3H12A	2386	multicellular organismal development
GO:0007588	6.557e-04	0.7667	7 AQP6, ATP6V0A4, ATP6V1B1, CLCNKA, KCNJ1, NPHS2, SCNN1A	47	excretion
GO:0048856	8.154e-04	35.19	59 AGTR2, AQP6, BARX2, CALCA, CER1, CLEC3A, COL4A3, COL4A4, CRYAA, CYP27B1, DMRT2, ELF5, EVPL, FOXI1, GATA3, GZF1, HELT, HMX2, HMX3, HOXA10, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC10, HOXC6, HOXC8, HOXD1, HOXD10, HOXD3, HOXD4, HOXD9, IL17F, IL18, ITGB3, KLK3, LMX1B, MDFI, NOX4, ODAM, PAX2, PAX8, PKHD1, PLA2G10, PLCG2, PODXL, RHCG, SCIN, SFTPB, SH2B2, SIM2, TBX2, TCOF1, TFCP2L1, TINAG, TSPAN2, VCAM1, ZC3H12A	2157	anatomical structure development
GO:0030878	8.459e-04	0.1631	4 HOXA3, HOXA5, HOXD3, PAX8	10	thyroid gland development
GO:0009887	9.307e-04	8.613	23 AQP6, BARX2, CRYAA, FOXI1, GZF1, HMX2, HMX3, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC8, HOXD10, HOXD3, HOXD4, HOXD9, MDFI, ODAM, PAX2, PODXL, SFTPB, TBX2	528	organ morphogenesis
GO:0048513	1.584e-03	24.67	45 AGTR2, AQP6, BARX2, CALCA, COL4A3, COL4A4, CRYAA, CYP27B1, DMRT2, ELF5, EVPL, FOXI1, GZF1, HMX2, HMX3, HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC8, HOXD10, HOXD3, HOXD4, HOXD9, IL17F, IL18, ITGB3, KLK3, LMX1B, MDFI, NOX4, ODAM, PAX2, PAX8, PKHD1, PLCG2, PODXL, RHCG, SCIN, SFTPB, TBX2, TFCP2L1, VCAM1, ZC3H12A	1512	organ development
GO:0006812	1.780e-03	7.798	21 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSPRY, CALCA, CYP27B1, FXYD2, KCNJ1, LTF, PLCG2, RHAG, RHCG, SCNN1A, SLC12A1, SLC12A3, SLC24A6, SLC34A1, SLC34A2, SLC34A3, SLC4A11	478	cation transport
GO:0015698	2.220e-03	0.6525	6 SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A11, WNK4	40	inorganic anion transport
GO:0015672	3.341e-03	4.143	14 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, FXYD2, KCNJ1, SCNN1A, SLC12A1, SLC12A3, SLC24A6, SLC34A1, SLC34A2, SLC34A3, SLC4A11	254	monovalent inorganic cation transport
GO:0006814	5.381e-03	1.909	9 FXYD2, SCNN1A, SLC12A1, SLC12A3, SLC24A6, SLC34A1, SLC34A2, SLC34A3, SLC4A11	117	sodium ion transport
GO:0043009	8.098e-03	5.155	15 HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC6, HOXD1, HOXD10, HOXD3, HOXD4, HOXD9, LMX1B, MDFI, SLC34A2, VCAM1	316	chordate embryonic development
GO:0009792	8.801e-03	5.204	15 HOXA3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC6, HOXD1, HOXD10, HOXD3, HOXD4, HOXD9, LMX1B, MDFI, SLC34A2, VCAM1	319	embryo development ending in birth or egg hatching
GO:0055061	8.896e-03	0.1305	3 SLC34A1, SLC34A2, SLC34A3	8	di-, tri-valent inorganic anion homeostasis
GO:0055062	8.896e-03	0.1305	3 SLC34A1, SLC34A2, SLC34A3	8	phosphate ion homeostasis
GO:0009954	1.194e-02	0.3426	4 HOXA10, HOXC10, HOXD10, HOXD9	21	proximal/distal pattern formation
GO:0032026	1.207e-02	0.1468	3 PLCG2, SLC34A1, SLC34A3	9	response to magnesium ion
GO:0048771	1.242e-02	0.9461	6 AGTR2, CALCA, HOXA3, ITGB3, NOX4, SLC34A1	58	tissue remodeling
GO:0030855	1.328e-02	2.219	9 CYP27B1, ELF5, EVPL, HOXA5, HOXA7, HOXB5, PAX2, RHCG, TFCP2L1	136	epithelial cell differentiation
GO:0006817	1.589e-02	0.1631	3 SLC34A1, SLC34A2, SLC34A3	10	phosphate transport
GO:0016525	2.311e-02	0.4241	4 COL4A3, HOXA5, IL17F, KLK3	26	negative regulation of angiogenesis
GO:0032836	2.339e-02	0.04894	2 COL4A3, COL4A4	3	glomerular basement membrane development
GO:0055081	2.462e-02	0.1958	3 SLC34A1, SLC34A2, SLC34A3	12	anion homeostasis
GO:0015992	2.870e-02	0.783	5 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, SLC4A11	48	proton transport
GO:0048869	3.100e-02	23.98	39 BARX2, CALCA, CRYAA, CYP27B1, ELF5, EVPL, HELT, HMX2, HMX3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC10, HOXC8, HOXD10, HOXD3, HOXD9, ITGB3, LMX1B, MDFI, NOX4, NPNT, PAPPA, PAX2, PAX8, PKHD1, PLA2G10, PLCG2, PTPRQ, RHCG, SCIN, SH2B2, SIM2, TBX2, TFCP2L1, TSPAN2, VCAM1, ZC3H12A	1470	cellular developmental process
GO:0030154	3.214e-02	23.23	38 BARX2, CALCA, CRYAA, CYP27B1, ELF5, EVPL, HELT, HMX2, HMX3, HOXA5, HOXA7, HOXB5, HOXB7, HOXC10, HOXC8, HOXD10, HOXD3, HOXD9, ITGB3, LMX1B, MDFI, NOX4, NPNT, PAPPA, PAX2, PAX8, PLA2G10, PLCG2, PTPRQ, RHCG, SCIN, SH2B2, SIM2, TBX2, TFCP2L1, TSPAN2, VCAM1, ZC3H12A	1424	cell differentiation
GO:0006818	3.288e-02	0.8156	5 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, SLC4A11	50	hydrogen transport
GO:0046849	3.413e-02	0.4894	4 CALCA, ITGB3, NOX4, SLC34A1	30	bone remodeling
GO:0048934	3.793e-02	0.06525	2 HOXD10, HOXD9	4	peripheral nervous system neuron differentiation
GO:0048935	3.793e-02	0.06525	2 HOXD10, HOXD9	4	peripheral nervous system neuron development
GO:0050801	4.610e-02	5.807	14 ATP6V0A4, ATP6V1B1, CALCA, CYP27B1, F2RL1, LTF, PLCG2, RHAG, RHCG, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11	356	ion homeostasis

Id	Pvalue	ExpCount	Count	Size	Term
GO:0045177	4.316e-09	2.869	19 ATP6V0A4, ATP6V0D2, ATP6V1B1, EPCAM, MUC1, PKHD1, PODXL, PROM2, RHCG, SCNN1A, SLC12A1, SLC12A3, SLC22A11, SLC22A12, SLC34A2, SLC34A3, SLC4A9, UMOD, VCAM1	170	apical part of cell
GO:0016324	6.704e-09	2.279	17 ATP6V0A4, ATP6V0D2, ATP6V1B1, EPCAM, MUC1, PKHD1, PODXL, PROM2, RHCG, SCNN1A, SLC12A1, SLC12A3, SLC22A11, SLC22A12, SLC34A2, SLC34A3, UMOD	135	apical plasma membrane
GO:0016471	7.489e-05	0.1181	4 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3	7	vacuolar proton-transporting V-type ATPase complex
GO:0031526	8.956e-04	0.4051	5 ATP6V0A4, SLC22A12, SLC34A1, SLC34A2, SLC34A3	24	brush border membrane
GO:0044459	1.302e-03	26.87	47 AGTR2, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CDH3, CLCNKA, CLDN4, CLDN8, EPCAM, EVPL, F2RL1, FXYD2, GABRP, IL1RL1, INSRR, ITGB3, ITGB6, KCNJ1, LRMP, MUC1, NOX4, NPHS2, PKHD1, PODXL, PROM2, PVRL4, RAB25, RHAG, RHCG, SCNN1A, SLC12A1, SLC12A3, SLC22A11, SLC22A12, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11, SLC4A9, TACSTD2, UMOD, VCAM1, WNK4	1592	plasma membrane part
GO:0033176	1.752e-03	0.2532	4 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3	15	proton-transporting V-type ATPase complex
GO:0031253	2.588e-03	1.536	8 ATP6V0A4, PODXL, PROM2, RAB25, SLC22A12, SLC34A1, SLC34A2, SLC34A3	91	cell projection membrane
GO:0005903	5.096e-03	0.6076	5 ATP6V0A4, SLC22A12, SLC34A1, SLC34A2, SLC34A3	36	brush border
GO:0005886	9.933e-03	44.29	64 AGTR2, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSND, CDCP1, CDH16, CDH3, CLCNKA, CLDN4, CLDN8, EPCAM, EVPL, F2RL1, FCAMR, FXYD2, GABRP, GPR110, ICAM4, IL1RL1, ILDR1, INSRR, ITGB3, ITGB6, KCNJ1, KIRREL, KIRREL2, LRMP, MUC1, NOX4, NPHS2, OLIG3, OR51E2, PKHD1, PLCG2, PODXL, PROM2, PVRL4, RAB19, RAB25, RAB38, RHAG, RHCG, SCNN1A, SH2B2, SLC12A1, SLC12A3, SLC22A11, SLC22A12, SLC24A6, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11, SLC4A9, TAAR1, TACSTD2, UMOD, VCAM1, WNK4	2624	plasma membrane
GO:0016323	1.909e-02	3.241	10 ATP6V1B1, BSND, EPCAM, NOX4, PROM2, RHCG, SLC26A7, SLC4A1, SLC4A11, SLC4A9	192	basolateral plasma membrane
GO:0005774	2.043e-02	1.722	7 ACPP, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, PLA2G4F, TSPAN1	102	vacuolar membrane
GO:0016469	2.096e-02	0.5232	4 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3	31	proton-transporting two-sector ATPase complex
GO:0005576	2.456e-02	23.75	38 ACPP, ADAMTS19, C8orf84, CALCA, CDCP1, CER1, CLEC3A, COL4A3, COL4A4, FAM3B, FBN3, ICAM4, IL17F, IL18, IL1RL1, IMPG1, KLK3, LTF, MMP1, MMP7, MUC1, NPNT, ODAM, OVCH2, PAPPA, PF4V1, PLA2G10, PVRL4, REG1A, REG3G, SFTPB, SOST, SOSTDC1, SRCRB4D, TINAG, UMOD, VCAM1, WFDC2	1407	extracellular region
GO:0044437	2.673e-02	1.823	7 ACPP, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, PLA2G4F, TSPAN1	108	vacuolar part
GO:0005587	3.067e-02	0.08439	2 COL4A3, COL4A4	5	collagen type IV
GO:0016021	3.123e-02	61.4	80 AGTR2, APCDD1L, AQP6, ATP6V0A4, B3GNT8, BSND, C12orf59, CA12, CDCP1, CDH16, CDH3, CLCNKA, CLDN4, CLDN8, EPCAM, F2RL1, FAM26D, FCAMR, FXYD2, GABRP, GGT6, GPR110, HEPACAM2, HHLA2, HRCT1, ICAM4, IL1RL1, ILDR1, INSRR, ITGB3, ITGB6, KCNJ1, KIRREL, KIRREL2, KLHDC7A, LRMP, LRRC19, MUC1, NOX4, NPHS2, OR51E2, PDZK1IP1, PKHD1, PODXL, PROM2, PTPRQ, PVRL4, RARRES1, RHAG, RHCG, SCNN1A, SLC12A1, SLC12A3, SLC1A7, SLC22A11, SLC22A12, SLC24A6, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC35F2, SLC45A2, SLC4A1, SLC4A11, SLC4A9, ST6GALNAC3, TAAR1, TACSTD2, TMC4, TMEM101, TMEM61, TMPRSS4, TSPAN1, TSPAN2, TSPAN33, TSPAN8, UNC5CL, VCAM1, ZDHHC6	3638	integral to membrane
GO:0031012	3.543e-02	4.81	12 ADAMTS19, C8orf84, COL4A3, COL4A4, FBN3, IMPG1, MMP1, MMP7, NPNT, ODAM, SOST, TINAG	285	extracellular matrix
GO:0031224	3.664e-02	62.74	81 AGTR2, APCDD1L, AQP6, ATP6V0A4, B3GNT8, BSND, C12orf59, CA12, CDCP1, CDH16, CDH3, CLCNKA, CLDN4, CLDN8, EPCAM, F2RL1, FAM26D, FCAMR, FXYD2, GABRP, GGT6, GPR110, HEPACAM2, HHLA2, HRCT1, ICAM4, IL1RL1, ILDR1, INSRR, ITGB3, ITGB6, KCNJ1, KIRREL, KIRREL2, KLHDC7A, LRMP, LRRC19, MUC1, NOX4, NPHS2, OR51E2, PDZK1IP1, PKHD1, PODXL, PROM2, PTPRQ, PVRL4, RARRES1, RHAG, RHCG, SCNN1A, SLC12A1, SLC12A3, SLC1A7, SLC22A11, SLC22A12, SLC24A6, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC35F2, SLC45A2, SLC4A1, SLC4A11, SLC4A9, ST6GALNAC3, TAAR1, TACSTD2, TMC4, TMEM101, TMEM61, TMPRSS4, TSPAN1, TSPAN2, TSPAN33, TSPAN8, UMOD, UNC5CL, VCAM1, ZDHHC6	3717	intrinsic to membrane
GO:0030935	4.205e-02	0.1013	2 COL4A3, COL4A4	6	sheet-forming collagen

Id	Pvalue	ExpCount	Count	Size	Term
GO:0008509	5.464e-08	1.844	15 AQP6, BSND, CLCNKA, GABRP, SLC12A1, SLC12A3, SLC1A7, SLC22A11, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11, SLC4A9	118	anion transmembrane transporter activity
GO:0043565	1.150e-06	7.188	26 BARX2, ELF5, FOXI1, GATA3, HMX2, HMX3, HOXA10, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB7, HOXC10, HOXC6, HOXC8, HOXC9, HOXD1, HOXD10, HOXD3, HOXD4, HOXD9, LMX1B, PAX2, PAX8, TBX2	460	sequence-specific DNA binding
GO:0015103	2.929e-05	0.4844	7 AQP6, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11	31	inorganic anion transmembrane transporter activity
GO:0003700	3.452e-05	11.06	30 BARX2, DMRT2, ELF5, FOXI1, GATA3, GRHL2, HELT, HMX2, HMX3, HOXA10, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB7, HOXC10, HOXC6, HOXC8, HOXC9, HOXD1, HOXD10, HOXD3, HOXD4, HOXD9, LMX1B, PAX8, SIM2, TBX2, TFCP2L1	708	sequence-specific DNA binding transcription factor activity
GO:0015380	1.995e-04	0.25	5 SLC22A11, SLC26A7, SLC4A1, SLC4A11, SLC4A9	16	anion exchanger activity
GO:0015301	2.689e-04	0.2656	5 SLC22A11, SLC26A7, SLC4A1, SLC4A11, SLC4A9	17	anion:anion antiporter activity
GO:0015291	4.003e-04	2.5	12 SLC12A1, SLC12A3, SLC1A7, SLC22A11, SLC24A6, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11, SLC4A9	160	secondary active transmembrane transporter activity
GO:0015075	1.058e-03	8.828	23 AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCNKA, FXYD2, GABRP, KCNJ1, RHAG, RHCG, SCNN1A, SLC12A1, SLC12A3, SLC1A7, SLC22A11, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11, SLC4A9	565	ion transmembrane transporter activity
GO:0005452	1.175e-03	0.1875	4 SLC22A11, SLC4A1, SLC4A11, SLC4A9	12	inorganic anion exchanger activity
GO:0022804	1.274e-03	4.328	15 ATP6V0A4, ATP6V1B1, FXYD2, SLC12A1, SLC12A3, SLC1A7, SLC22A11, SLC24A6, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11, SLC4A9	277	active transmembrane transporter activity
GO:0015321	1.594e-03	0.07812	3 SLC34A1, SLC34A2, SLC34A3	5	sodium-dependent phosphate transmembrane transporter activity
GO:0022857	1.774e-03	11.12	26 AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSND, CLCNKA, FXYD2, GABRP, KCNJ1, RHAG, RHCG, SCNN1A, SLC12A1, SLC12A3, SLC1A7, SLC22A11, SLC22A12, SLC24A6, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11, SLC4A9	712	transmembrane transporter activity
GO:0022891	2.743e-03	10.14	24 AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCNKA, FXYD2, GABRP, KCNJ1, RHAG, RHCG, SCNN1A, SLC12A1, SLC12A3, SLC1A7, SLC22A11, SLC22A12, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11, SLC4A9	649	substrate-specific transmembrane transporter activity
GO:0015296	3.446e-03	0.4688	5 SLC12A1, SLC12A3, SLC1A7, SLC34A2, SLC34A3	30	anion:cation symporter activity
GO:0030506	4.477e-03	0.1094	3 RHAG, RHCG, SLC4A1	7	ankyrin binding
GO:0015297	6.149e-03	0.8438	6 SLC22A11, SLC24A6, SLC26A7, SLC4A1, SLC4A11, SLC4A9	54	antiporter activity
GO:0022892	8.396e-03	11.78	25 AP1S3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCNKA, FXYD2, GABRP, KCNJ1, RHAG, RHCG, SCNN1A, SLC12A1, SLC12A3, SLC1A7, SLC22A11, SLC22A12, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11, SLC4A9	754	substrate-specific transporter activity
GO:0005215	1.152e-02	14.25	28 AP1S3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSND, CLCNKA, FXYD2, GABRP, KCNJ1, RHAG, RHCG, SCNN1A, SLC12A1, SLC12A3, SLC1A7, SLC22A11, SLC22A12, SLC24A6, SLC26A7, SLC34A1, SLC34A2, SLC34A3, SLC4A1, SLC4A11, SLC4A9, TCOF1	912	transporter activity
GO:0015300	1.312e-02	0.6562	5 SLC22A11, SLC26A7, SLC4A1, SLC4A11, SLC4A9	42	solute:solute antiporter activity
GO:0008519	1.829e-02	0.04688	2 RHAG, RHCG	3	ammonium transmembrane transporter activity
GO:0015294	2.276e-02	1.141	6 SLC12A1, SLC12A3, SLC1A7, SLC34A2, SLC34A3, SLC4A11	73	solute:cation symporter activity
GO:0015114	2.276e-02	0.2031	3 SLC34A1, SLC34A2, SLC34A3	13	phosphate transmembrane transporter activity
GO:0022890	2.562e-02	2.578	9 ATP6V0A4, ATP6V0D2, ATP6V1B1, FXYD2, RHAG, RHCG, SLC1A7, SLC34A2, SLC34A3	165	inorganic cation transmembrane transporter activity
GO:0005178	2.963e-02	0.8281	5 COL4A3, ICAM4, ITGB3, ITGB6, VCAM1	53	integrin binding
GO:0015293	3.019e-02	1.672	7 SLC12A1, SLC12A3, SLC1A7, SLC34A1, SLC34A2, SLC34A3, SLC4A11	107	symporter activity
GO:0015106	3.041e-02	0.0625	2 SLC26A7, SLC4A11	4	bicarbonate transmembrane transporter activity
GO:0005044	3.706e-02	0.5312	4 C8orf84, SRCRB4D, TINAG, TMPRSS4	34	scavenger receptor activity

Id	Pvalue	ExpCount	Count	Size	Term
04966	1.971e-04	0.2628	5 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, SLC4A1	21	Collecting duct acid secretion
05110	3.491e-03	0.5005	5 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, PLCG2	40	Vibrio cholerae infection
05120	1.051e-02	0.6632	5 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, PLCG2	53	Epithelial cell signaling in Helicobacter pylori infection
04960	1.477e-02	0.4129	4 FXYD2, HSD11B2, KCNJ1, SCNN1A	33	Aldosterone-regulated sodium reabsorption

No enriched terms

No enriched terms

Entrez genes

ACPPacid phosphatase, prostate (ENSG00000014257), score: 0.47 ADAMTS19ADAM metallopeptidase with thrombospondin type 1 motif, 19 (ENSG00000145808), score: 0.44 AGTR2angiotensin II receptor, type 2 (ENSG00000180772), score: 0.77 AP1M2adaptor-related protein complex 1, mu 2 subunit (ENSG00000129354), score: 0.47 AP1S3adaptor-related protein complex 1, sigma 3 subunit (ENSG00000152056), score: 0.49 APCDD1Ladenomatosis polyposis coli down-regulated 1-like (ENSG00000198768), score: 0.62 AQP6aquaporin 6, kidney specific (ENSG00000086159), score: 0.58 ARMC7armadillo repeat containing 7 (ENSG00000125449), score: 0.58 ARRDC4arrestin domain containing 4 (ENSG00000140450), score: 0.45 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.54 ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (ENSG00000147614), score: 0.53 ATP6V1B1ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (ENSG00000116039), score: 0.51 ATP6V1G3ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 (ENSG00000151418), score: 0.6 B3GNT8UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 (ENSG00000177191), score: 0.44 BARX2BARX homeobox 2 (ENSG00000043039), score: 0.58 BFSP2beaded filament structural protein 2, phakinin (ENSG00000170819), score: 0.76 BSNDBartter syndrome, infantile, with sensorineural deafness (Barttin) (ENSG00000162399), score: 0.56 BSPRYB-box and SPRY domain containing (ENSG00000119411), score: 0.47 C12orf59chromosome 12 open reading frame 59 (ENSG00000165685), score: 0.48 C19orf21chromosome 19 open reading frame 21 (ENSG00000099812), score: 0.55 C7orf64chromosome 7 open reading frame 64 (ENSG00000127993), score: -0.47 C8orf84chromosome 8 open reading frame 84 (ENSG00000164764), score: 0.54 CA12carbonic anhydrase XII (ENSG00000074410), score: 0.45 CALCAcalcitonin-related polypeptide alpha (ENSG00000110680), score: 0.62 CAPGcapping protein (actin filament), gelsolin-like (ENSG00000042493), score: 0.5 CCDC64Bcoiled-coil domain containing 64B (ENSG00000162069), score: 0.47 CDCP1CUB domain containing protein 1 (ENSG00000163814), score: 0.55 CDH16cadherin 16, KSP-cadherin (ENSG00000166589), score: 0.49 CDH3cadherin 3, type 1, P-cadherin (placental) (ENSG00000062038), score: 0.5 CER1cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis) (ENSG00000147869), score: 0.54 CLCNKAchloride channel Ka (ENSG00000186510), score: 0.49 CLDN4claudin 4 (ENSG00000189143), score: 0.55 CLDN8claudin 8 (ENSG00000156284), score: 0.47 CLEC3AC-type lectin domain family 3, member A (ENSG00000166509), score: 0.9 CLNKcytokine-dependent hematopoietic cell linker (ENSG00000109684), score: 0.54 COL4A3collagen, type IV, alpha 3 (Goodpasture antigen) (ENSG00000169031), score: 0.53 COL4A4collagen, type IV, alpha 4 (ENSG00000081052), score: 0.47 CRYAAcrystallin, alpha A (ENSG00000160202), score: 0.55 CYP27B1cytochrome P450, family 27, subfamily B, polypeptide 1 (ENSG00000111012), score: 0.49 DACT2dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis) (ENSG00000164488), score: 0.47 DHDHdihydrodiol dehydrogenase (dimeric) (ENSG00000104808), score: 0.44 DMRT2doublesex and mab-3 related transcription factor 2 (ENSG00000173253), score: 0.6 DUSP9dual specificity phosphatase 9 (ENSG00000130829), score: 0.46 EAF2ELL associated factor 2 (ENSG00000145088), score: 0.49 ELF5E74-like factor 5 (ets domain transcription factor) (ENSG00000135374), score: 0.5 EPCAMepithelial cell adhesion molecule (ENSG00000119888), score: 0.46 EPS8L1EPS8-like 1 (ENSG00000131037), score: 0.5 ERP27endoplasmic reticulum protein 27 (ENSG00000139055), score: 0.6 EVPLenvoplakin (ENSG00000167880), score: 0.5 F2RL1coagulation factor II (thrombin) receptor-like 1 (ENSG00000164251), score: 0.49 FAM26Dfamily with sequence similarity 26, member D (ENSG00000164451), score: 0.53 FAM3Bfamily with sequence similarity 3, member B (ENSG00000183844), score: 0.49 FBN3fibrillin 3 (ENSG00000142449), score: 0.56 FCAMRFc receptor, IgA, IgM, high affinity (ENSG00000162897), score: 0.55 FOXI1forkhead box I1 (ENSG00000168269), score: 0.53 FRMD1FERM domain containing 1 (ENSG00000153303), score: 0.54 FXYD2FXYD domain containing ion transport regulator 2 (ENSG00000137731), score: 0.46 GABRPgamma-aminobutyric acid (GABA) A receptor, pi (ENSG00000094755), score: 0.44 GATA3GATA binding protein 3 (ENSG00000107485), score: 0.51 GGT6gamma-glutamyltransferase 6 (ENSG00000167741), score: 0.53 GPR110G protein-coupled receptor 110 (ENSG00000153292), score: 0.59 GRHL2grainyhead-like 2 (Drosophila) (ENSG00000083307), score: 0.51 GZF1GDNF-inducible zinc finger protein 1 (ENSG00000125812), score: -0.48 HELTHES/HEY-like transcription factor (ENSG00000187821), score: 0.51 HEPACAM2HEPACAM family member 2 (ENSG00000188175), score: 0.5 HHLA2HERV-H LTR-associating 2 (ENSG00000114455), score: 0.65 HMX2H6 family homeobox 2 (ENSG00000188816), score: 0.45 HMX3H6 family homeobox 3 (ENSG00000188620), score: 0.67 HOXA10homeobox A10 (ENSG00000153807), score: 0.6 HOXA3homeobox A3 (ENSG00000105997), score: 0.44 HOXA5homeobox A5 (ENSG00000106004), score: 0.46 HOXA7homeobox A7 (ENSG00000122592), score: 0.47 HOXA9homeobox A9 (ENSG00000078399), score: 0.53 HOXB5homeobox B5 (ENSG00000120075), score: 0.53 HOXB7homeobox B7 (ENSG00000120087), score: 0.48 HOXC10homeobox C10 (ENSG00000180818), score: 0.47 HOXC6homeobox C6 (ENSG00000197757), score: 0.52 HOXC8homeobox C8 (ENSG00000037965), score: 0.47 HOXC9homeobox C9 (ENSG00000180806), score: 0.51 HOXD1homeobox D1 (ENSG00000128645), score: 0.46 HOXD10homeobox D10 (ENSG00000128710), score: 0.56 HOXD3homeobox D3 (ENSG00000128652), score: 0.45 HOXD4homeobox D4 (ENSG00000170166), score: 0.44 HOXD9homeobox D9 (ENSG00000128709), score: 0.54 HRCT1histidine rich carboxyl terminus 1 (ENSG00000196196), score: 0.44 HSD11B2hydroxysteroid (11-beta) dehydrogenase 2 (ENSG00000176387), score: 0.44 ICAM4intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) (ENSG00000105371), score: 0.44 IL17Finterleukin 17F (ENSG00000112116), score: 0.5 IL18interleukin 18 (interferon-gamma-inducing factor) (ENSG00000150782), score: 0.46 IL1RL1interleukin 1 receptor-like 1 (ENSG00000115602), score: 0.44 ILDR1immunoglobulin-like domain containing receptor 1 (ENSG00000145103), score: 0.54 IMPG1interphotoreceptor matrix proteoglycan 1 (ENSG00000112706), score: 0.44 INSRRinsulin receptor-related receptor (ENSG00000027644), score: 0.47 ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ENSG00000056345), score: 0.45 ITGB6integrin, beta 6 (ENSG00000115221), score: 0.45 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.51 KIF12kinesin family member 12 (ENSG00000136883), score: 0.45 KIRRELkin of IRRE like (Drosophila) (ENSG00000183853), score: 0.49 KIRREL2kin of IRRE like 2 (Drosophila) (ENSG00000126259), score: 0.44 KLHDC7Akelch domain containing 7A (ENSG00000179023), score: 0.5 KLK3kallikrein-related peptidase 3 (ENSG00000142515), score: 0.67 KRT7keratin 7 (ENSG00000135480), score: 0.55 LGALS2lectin, galactoside-binding, soluble, 2 (ENSG00000100079), score: 0.46 LMX1BLIM homeobox transcription factor 1, beta (ENSG00000136944), score: 0.55 LRMPlymphoid-restricted membrane protein (ENSG00000118308), score: 0.44 LRRC19leucine rich repeat containing 19 (ENSG00000184434), score: 0.44 LTFlactotransferrin (ENSG00000012223), score: 0.69 MACC1metastasis associated in colon cancer 1 (ENSG00000183742), score: 0.64 MCCD1mitochondrial coiled-coil domain 1 (ENSG00000204511), score: 0.47 MDFIMyoD family inhibitor (ENSG00000112559), score: 0.44 MIOXmyo-inositol oxygenase (ENSG00000100253), score: 0.45 MMP1matrix metallopeptidase 1 (interstitial collagenase) (ENSG00000196611), score: 1 MMP7matrix metallopeptidase 7 (matrilysin, uterine) (ENSG00000137673), score: 0.66 MUC1mucin 1, cell surface associated (ENSG00000185499), score: 0.51 MXI1MAX interactor 1 (ENSG00000119950), score: -0.45 MYO19myosin XIX (ENSG00000141140), score: 0.46 NCCRP1non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) (ENSG00000188505), score: 0.49 NLRP9NLR family, pyrin domain containing 9 (ENSG00000185792), score: 0.47 NOX4NADPH oxidase 4 (ENSG00000086991), score: 0.44 NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin) (ENSG00000116218), score: 0.55 NPNTnephronectin (ENSG00000168743), score: 0.43 NQO2NAD(P)H dehydrogenase, quinone 2 (ENSG00000124588), score: 0.44 ODAModontogenic, ameloblast asssociated (ENSG00000109205), score: 0.45 OLIG3oligodendrocyte transcription factor 3 (ENSG00000177468), score: 0.53 OR51E2olfactory receptor, family 51, subfamily E, member 2 (ENSG00000167332), score: 0.45 OVCH2ovochymase 2 (gene/pseudogene) (ENSG00000183378), score: 0.55 PAPPApregnancy-associated plasma protein A, pappalysin 1 (ENSG00000182752), score: 0.44 PAX2paired box 2 (ENSG00000075891), score: 0.47 PAX8paired box 8 (ENSG00000125618), score: 0.54 PDCD7programmed cell death 7 (ENSG00000090470), score: -0.45 PDZK1IP1PDZK1 interacting protein 1 (ENSG00000162366), score: 0.44 PF4V1platelet factor 4 variant 1 (ENSG00000109272), score: 0.64 PKHD1polycystic kidney and hepatic disease 1 (autosomal recessive) (ENSG00000170927), score: 0.49 PLA2G10phospholipase A2, group X (ENSG00000069764), score: 0.43 PLA2G4Fphospholipase A2, group IVF (ENSG00000168907), score: 0.54 PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific) (ENSG00000197943), score: 0.43 PODXLpodocalyxin-like (ENSG00000128567), score: 0.44 PPP1R14Dprotein phosphatase 1, regulatory (inhibitor) subunit 14D (ENSG00000166143), score: 0.76 PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit (ENSG00000111725), score: 0.47 PROM2prominin 2 (ENSG00000155066), score: 0.47 PRR15proline rich 15 (ENSG00000176532), score: 0.55 PTPRQprotein tyrosine phosphatase, receptor type, Q (ENSG00000139304), score: 0.68 PVRL4poliovirus receptor-related 4 (ENSG00000143217), score: 0.48 RAB19RAB19, member RAS oncogene family (ENSG00000146955), score: 0.62 RAB25RAB25, member RAS oncogene family (ENSG00000132698), score: 0.56 RAB38RAB38, member RAS oncogene family (ENSG00000123892), score: 0.45 RARRES1retinoic acid receptor responder (tazarotene induced) 1 (ENSG00000118849), score: 0.5 RASSF10Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 (ENSG00000189431), score: 0.61 REG1Aregenerating islet-derived 1 alpha (ENSG00000115386), score: 0.91 REG3Gregenerating islet-derived 3 gamma (ENSG00000143954), score: 0.96 RGL3ral guanine nucleotide dissociation stimulator-like 3 (ENSG00000205517), score: 0.48 RHAGRh-associated glycoprotein (ENSG00000112077), score: 0.48 RHCGRh family, C glycoprotein (ENSG00000140519), score: 0.5 S100A2S100 calcium binding protein A2 (ENSG00000196754), score: 0.53 SCINscinderin (ENSG00000006747), score: 0.46 SCNN1Asodium channel, nonvoltage-gated 1 alpha (ENSG00000111319), score: 0.49 SFTPBsurfactant protein B (ENSG00000168878), score: 0.52 SH2B2SH2B adaptor protein 2 (ENSG00000160999), score: 0.49 SIM2single-minded homolog 2 (Drosophila) (ENSG00000159263), score: 0.49 SLC12A1solute carrier family 12 (sodium/potassium/chloride transporters), member 1 (ENSG00000074803), score: 0.46 SLC12A3solute carrier family 12 (sodium/chloride transporters), member 3 (ENSG00000070915), score: 0.43 SLC1A7solute carrier family 1 (glutamate transporter), member 7 (ENSG00000162383), score: 0.63 SLC22A11solute carrier family 22 (organic anion/urate transporter), member 11 (ENSG00000168065), score: 0.44 SLC22A12solute carrier family 22 (organic anion/urate transporter), member 12 (ENSG00000197891), score: 0.44 SLC24A6solute carrier family 24 (sodium/potassium/calcium exchanger), member 6 (ENSG00000089060), score: 0.46 SLC26A7solute carrier family 26, member 7 (ENSG00000147606), score: 0.57 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 0.46 SLC34A2solute carrier family 34 (sodium phosphate), member 2 (ENSG00000157765), score: 0.51 SLC34A3solute carrier family 34 (sodium phosphate), member 3 (ENSG00000198569), score: 0.47 SLC35F2solute carrier family 35, member F2 (ENSG00000110660), score: 0.43 SLC45A2solute carrier family 45, member 2 (ENSG00000164175), score: 0.79 SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (ENSG00000004939), score: 0.47 SLC4A11solute carrier family 4, sodium borate transporter, member 11 (ENSG00000088836), score: 0.45 SLC4A9solute carrier family 4, sodium bicarbonate cotransporter, member 9 (ENSG00000113073), score: 0.51 SNX32sorting nexin 32 (ENSG00000172803), score: -0.48 SOSTsclerostin (ENSG00000167941), score: 0.51 SOSTDC1sclerostin domain containing 1 (ENSG00000171243), score: 0.49 SP6Sp6 transcription factor (ENSG00000189120), score: 0.64 SRCRB4Dscavenger receptor cysteine rich domain containing, group B (4 domains) (ENSG00000146700), score: 0.51 ST6GALNAC3ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (ENSG00000184005), score: 0.45 STAP1signal transducing adaptor family member 1 (ENSG00000035720), score: 0.78 STK19serine/threonine kinase 19 (ENSG00000204344), score: 0.52 STK32Aserine/threonine kinase 32A (ENSG00000169302), score: 0.47 TAAR1trace amine associated receptor 1 (ENSG00000146399), score: 0.57 TACSTD2tumor-associated calcium signal transducer 2 (ENSG00000184292), score: 0.58 TBX2T-box 2 (ENSG00000121068), score: 0.46 TCOF1Treacher Collins-Franceschetti syndrome 1 (ENSG00000070814), score: 0.49 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.52 TINAGtubulointerstitial nephritis antigen (ENSG00000137251), score: 0.46 TMC4transmembrane channel-like 4 (ENSG00000167608), score: 0.46 TMEM101transmembrane protein 101 (ENSG00000091947), score: 0.55 TMEM61transmembrane protein 61 (ENSG00000143001), score: 0.44 TMPRSS4transmembrane protease, serine 4 (ENSG00000137648), score: 0.53 TSPAN1tetraspanin 1 (ENSG00000117472), score: 0.45 TSPAN2tetraspanin 2 (ENSG00000134198), score: 0.58 TSPAN33tetraspanin 33 (ENSG00000158457), score: 0.44 TSPAN8tetraspanin 8 (ENSG00000127324), score: 0.49 UMODuromodulin (ENSG00000169344), score: 0.53 UNC5CLunc-5 homolog C (C. elegans)-like (ENSG00000124602), score: 0.46 VCAM1vascular cell adhesion molecule 1 (ENSG00000162692), score: 0.5 WFDC2WAP four-disulfide core domain 2 (ENSG00000101443), score: 0.5 WNK4WNK lysine deficient protein kinase 4 (ENSG00000126562), score: 0.59 ZC3H12Azinc finger CCCH-type containing 12A (ENSG00000163874), score: 0.48 ZC3H12Dzinc finger CCCH-type containing 12D (ENSG00000178199), score: 0.55 ZDHHC6zinc finger, DHHC-type containing 6 (ENSG00000023041), score: 0.44

Non-Entrez genes

ENSG00000204511Unknown, score: 0.9 ENSG00000118849Unknown, score: 0.48 ENSG00000189431Unknown, score: 0.45 ENSG00000163814Unknown, score: 0.56

Id	species	tissue	sex	individual
ppa_kd_m_ca1	ppa	kd	m	_
ptr_kd_f_ca1	ptr	kd	f	_
ppa_kd_f_ca1	ppa	kd	f	_