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skeletal system development

The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

regionalization

The pattern specification process by which an axis or axes is subdivided in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

anion transport

The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

embryo development

The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.

pattern specification process

Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

response to nutrient

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

body fluid secretion

The controlled release of a fluid by a cell or group of cells in a multicellular organism.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

embryo development ending in birth or egg hatching

The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.

anterior/posterior pattern formation

The regionalization process by which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to extracellular stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

organic cation transport

The directed movement of organic cations into, out of, within or between cells by means of some external agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.

organic anion transport

The directed movement of organic anions into, out of, within or between cells by means of some external agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.

organic acid transport

The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells by means of some external agent such as a transporter or pore.

vitamin transport

The directed movement of vitamins into, out of, within or between cells by means of some external agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

signaling pathway

The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.

intracellular signaling pathway

The series of molecular events whereby information is sent from one location to another within a cell.

signaling

The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

intracellular receptor mediated signaling pathway

Any series of molecular signals initiated by a ligand binding to an receptor located within a cell.

epithelial cell differentiation

The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

thyroid gland development

The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.

response to nutrient levels

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.

cellular response to extracellular stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

cellular response to nutrient levels

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.

cellular response to nutrient

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

response to vitamin

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.

response to vitamin D

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.

endocrine system development

Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

homeostatic process

Any biological process involved in the maintenance of an internal steady-state.

chordate embryonic development

The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.

carboxylic acid transport

The directed movement of carboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ morphogenesis

Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ development

Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic morphogenesis

The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.

embryonic skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form.

skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized. Morphogenesis pertains to the creation of form.

embryonic skeletal system development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

gland development

The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

epithelium development

The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

vitamin D receptor signaling pathway

The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands.

cellular response to chemical stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

cellular response to vitamin

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.

cellular response to vitamin D

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.

cellular response to external stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

all

NA

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular response to extracellular stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

embryo development

The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.

pattern specification process

Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

embryonic morphogenesis

The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

cellular response to chemical stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ morphogenesis

Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ morphogenesis

Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

embryonic organ development

Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

cellular response to extracellular stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

cellular response to extracellular stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

cellular response to nutrient

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

body fluid secretion

The controlled release of a fluid by a cell or group of cells in a multicellular organism.

cellular response to nutrient

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized. Morphogenesis pertains to the creation of form.

embryonic skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form.

embryonic skeletal system development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.

epithelial cell differentiation

The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

thyroid gland development

The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.

response to nutrient

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

cellular response to nutrient levels

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.

cellular response to vitamin

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.

embryonic skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form.

cellular response to vitamin D

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

vitamin D receptor signaling pathway

The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

brush border

Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.

basolateral plasma membrane

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

organelle membrane

The lipid bilayer surrounding an organelle.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

nucleic acid binding

Interacting selectively and non-covalently with any nucleic acid.

DNA binding

Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).

sequence-specific DNA binding transcription factor activity

Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

monooxygenase activity

Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

sodium channel activity

Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

amine transmembrane transporter activity

Catalysis of the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

organic acid transmembrane transporter activity

Catalysis of the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other.

secondary active transmembrane transporter activity

Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.

inorganic anion exchanger activity

NA

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

anion transmembrane transporter activity

Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

monovalent inorganic cation transmembrane transporter activity

Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

organic cation transmembrane transporter activity

Catalysis of the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.

inorganic anion transmembrane transporter activity

Catalysis of the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.

drug transmembrane transporter activity

Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.

channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

amiloride-sensitive sodium channel activity

NA

symporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

solute:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).

anion:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in).

antiporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

solute:solute antiporter activity

Catalysis of the reaction: solute A(out) + solute B(in) = solute A(in) + solute B(out).

anion:anion antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).

anion exchanger activity

NA

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.

passive transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.

active transmembrane transporter activity

Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.

ligand-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

inorganic cation transmembrane transporter activity

Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

sequence-specific DNA binding

Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

carboxylic acid transmembrane transporter activity

Catalysis of the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.

amine transmembrane transporter activity

Catalysis of the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

solute:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

anion:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in).

anion:anion antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).

amiloride-sensitive sodium channel activity

NA

Id	Pvalue	ExpCount	Count	Size	Term
GO:0006811	2.712e-12	13.94	49 ABCC4, AQP2, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, CLCNKA, CLDN16, CSN2, CYP27B1, EGF, KCNJ1, KCNJ16, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC26A7, SLC34A1, SLC34A3, SLC4A1, SLC5A10, SLC5A12, SLC5A8, SLC9A4, SLCO4C1, TCN2, TRPM6, TRPV4, VDR, WNK4	663	ion transport
GO:0007588	1.162e-11	0.9884	15 AQP2, AQP6, ATP6V0A4, ATP6V1B1, BTC, CLCNKA, CLDN16, DAB2, KCNJ1, NPHS2, OXT, SCNN1A, SCNN1B, SCNN1G, SCTR	47	excretion
GO:0006812	3.446e-10	10.05	38 AQP2, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, CSN2, CYP27B1, EGF, KCNJ1, KCNJ16, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC34A1, SLC34A3, SLC5A10, SLC5A12, SLC5A8, SLC9A4, TCN2, TRPM6, TRPV4, VDR	478	cation transport
GO:0055085	7.216e-09	12.34	40 ABCC4, AQP2, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, CLCNKA, EGF, RHCG, SFXN2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A3, SLC25A45, SLC26A7, SLC5A10, SLC5A12, SLC5A8, SLC7A13, SLC7A8, SLC7A9, SLC9A4, TRPM6, TRPV4	587	transmembrane transport
GO:0006814	9.535e-09	2.46	18 SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC22A4, SLC22A5, SLC34A1, SLC34A3, SLC5A10, SLC5A12, SLC5A8, SLC9A4	117	sodium ion transport
GO:0015672	2.689e-08	5.342	25 ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, KCNJ1, KCNJ16, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC22A4, SLC22A5, SLC34A1, SLC34A3, SLC5A10, SLC5A12, SLC5A8, SLC9A4	254	monovalent inorganic cation transport
GO:0048704	4.564e-08	1.009	12 HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXD10, HOXD3, HOXD4, HOXD9, TFAP2A	48	embryonic skeletal system morphogenesis
GO:0009952	5.973e-08	2.439	17 HNF1B, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9	116	anterior/posterior pattern formation
GO:0048706	2.788e-07	1.451	13 HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC6, HOXD10, HOXD3, HOXD4, HOXD9, TFAP2A	69	embryonic skeletal system development
GO:0006810	3.634e-07	46.81	85 ABCC4, AFP, AGR2, AP1S3, AQP2, AQP6, ARSB, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BTC, CLCNKA, CLDN16, CLINT1, CSN2, CUBN, CYP27B1, DAB2, EGF, GPR172B, HNF1B, KCNJ1, KCNJ16, NPHS2, OXT, PRLR, RAB19, RAB25, RAB7L1, RHCG, SCIN, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A3, SLC25A45, SLC26A7, SLC34A1, SLC34A3, SLC4A1, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9, SLC9A4, SLCO4C1, STRA6, TCN2, TNFSF15, TRPM6, TRPV4, UCN3, VAV3, VDR, WNK4	2226	transport
GO:0030001	3.644e-07	8.622	30 AQP2, ATP12A, CSN2, CYP27B1, EGF, KCNJ1, KCNJ16, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC22A4, SLC22A5, SLC34A1, SLC34A3, SLC5A10, SLC5A12, SLC5A8, SLC9A4, TCN2, TRPM6, TRPV4, VDR	410	metal ion transport
GO:0051234	6.085e-07	47.36	85 ABCC4, AFP, AGR2, AP1S3, AQP2, AQP6, ARSB, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BTC, CLCNKA, CLDN16, CLINT1, CSN2, CUBN, CYP27B1, DAB2, EGF, GPR172B, HNF1B, KCNJ1, KCNJ16, NPHS2, OXT, PRLR, RAB19, RAB25, RAB7L1, RHCG, SCIN, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A3, SLC25A45, SLC26A7, SLC34A1, SLC34A3, SLC4A1, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9, SLC9A4, SLCO4C1, STRA6, TCN2, TNFSF15, TRPM6, TRPV4, UCN3, VAV3, VDR, WNK4	2252	establishment of localization
GO:0051179	9.295e-07	54.53	93 ABCC4, AFP, AGR2, ALOX12, AP1S3, AQP2, AQP6, ARSB, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BTC, CLCNKA, CLDN16, CLINT1, CSN2, CUBN, CYP27B1, DAB2, EGF, F2RL1, GPR172B, HNF1B, HOXA5, HOXA7, IL12B, KCNJ1, KCNJ16, NPHS2, OXT, PARD6B, PKHD1, PLAU, PRLR, RAB19, RAB25, RAB7L1, RHCG, SCIN, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A3, SLC25A45, SLC26A7, SLC34A1, SLC34A3, SLC4A1, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9, SLC9A4, SLCO4C1, STRA6, TCN2, TNFSF15, TRPM6, TRPV4, UCN3, VAV3, VDR, WNK4	2593	localization
GO:0048705	1.891e-06	2.04	14 HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, TFAP2A	97	skeletal system morphogenesis
GO:0006820	7.518e-06	1.619	12 SLC10A2, SLC13A1, SLC13A3, SLC22A11, SLC22A12, SLC22A6, SLC22A8, SLC26A7, SLC34A1, SLC34A3, SLC4A1, WNK4	77	anion transport
GO:0048562	9.102e-06	2.334	14 FOXI1, HMX2, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXD10, HOXD3, HOXD4, HOXD9, TFAP2A	111	embryonic organ morphogenesis
GO:0003002	1.919e-05	3.722	17 HNF1B, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9	177	regionalization
GO:0001501	2.313e-05	4.69	19 EVC, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, TFAP2A, VDR	223	skeletal system development
GO:0046903	2.665e-05	8.37	26 AGR2, AQP2, AQP6, ATP6V0A4, ATP6V1B1, BTC, CLCNKA, CLDN16, DAB2, EGF, HNF1B, KCNJ1, NPHS2, OXT, PRLR, SCIN, SCNN1A, SCNN1B, SCNN1G, SCTR, SLC22A2, SLC22A4, TNFSF15, TRPV4, UCN3, VDR	398	secretion
GO:0032501	4.920e-05	69.4	104 AFP, AGR2, ALOX12, AQP2, AQP6, ARSB, ATP6V0A4, ATP6V1B1, BICC1, BPGM, BTC, CALCR, CASR, CDH3, CLCNKA, CLDN16, CLDN19, COCH, COL4A3, CUBN, CYP24A1, CYP27B1, DAB2, DMRT2, EGF, ELF5, EVC, F2RL1, FOXI1, GCM1, HMX2, HNF1B, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB6, HOXB7, HOXC10, HOXC6, HOXC8, HOXC9, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, HSD11B2, HTR1D, IL12B, INSRR, KCNJ1, KL, KRT3, LGMN, MMP13, MYO3B, NHS, NOX4, NPHS2, NTRK1, OLR1, OR10Q1, OR51E1, OXT, PAQR5, PARD6B, PAX2, PAX8, PKHD1, PLAU, PRLR, REN, RHCG, SCIN, SCNN1A, SCNN1B, SCNN1G, SCTR, SHISA2, SIM1, SIM2, SLC12A6, SLC22A2, SLC22A4, SLC22A5, SLC34A1, SLC6A4, SLCO4C1, SOX14, TAL2, TFAP2A, TFAP2B, TFCP2L1, TINAG, TNFSF15, UPK2, USH1C, VAV3, VDR, WNT9B	3300	multicellular organismal process
GO:0048568	2.995e-04	3.68	15 FOXI1, GCM1, HMX2, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXD10, HOXD3, HOXD4, HOXD9, TFAP2A	175	embryonic organ development
GO:0015849	3.664e-04	2.839	13 OXT, SLC10A2, SLC13A3, SLC16A4, SLC22A12, SLC22A4, SLC22A5, SLC22A6, SLC26A7, SLC6A19, SLC7A13, SLC7A8, SLC7A9	135	organic acid transport
GO:0007389	3.891e-04	4.753	17 HNF1B, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9	226	pattern specification process
GO:0048598	3.938e-04	5.804	19 FOXI1, GCM1, HMX2, HNF1B, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXD10, HOXD3, HOXD4, HOXD9, TFAP2A, TINAG	276	embryonic morphogenesis
GO:0015711	6.609e-04	0.7781	7 SLC10A2, SLC13A3, SLC22A11, SLC22A12, SLC22A6, SLC22A8, SLC26A7	37	organic anion transport
GO:0046942	1.421e-03	2.818	12 OXT, SLC10A2, SLC13A3, SLC16A4, SLC22A4, SLC22A5, SLC22A6, SLC26A7, SLC6A19, SLC7A13, SLC7A8, SLC7A9	134	carboxylic acid transport
GO:0070561	1.973e-03	0.08412	3 CYP24A1, CYP27B1, VDR	4	vitamin D receptor signaling pathway
GO:0071305	1.973e-03	0.08412	3 CYP24A1, CYP27B1, VDR	4	cellular response to vitamin D
GO:0030878	1.974e-03	0.2103	4 HOXA3, HOXA5, HOXD3, PAX8	10	thyroid gland development
GO:0015695	2.447e-03	0.4206	5 RHCG, SLC22A13, SLC22A2, SLC22A4, SLC22A5	20	organic cation transport
GO:0051180	5.374e-03	0.5047	5 CUBN, GPR172B, SLC22A4, SLC22A5, TCN2	24	vitamin transport
GO:0030855	5.862e-03	2.86	11 ALOX12, CYP27B1, ELF5, HOXA5, HOXA7, HOXB5, KRT3, PAX2, RHCG, TFCP2L1, UPK2	136	epithelial cell differentiation
GO:0007589	6.129e-03	1.157	7 AGR2, BTC, OXT, PRLR, SLC22A2, SLC22A4, VDR	55	body fluid secretion
GO:0042592	9.603e-03	13.75	28 ALOX12, AQP2, ATP6V0A4, ATP6V1B1, BPGM, BTC, CALCR, CASR, CLDN16, CUBN, CYP27B1, F2RL1, GYLTL1B, HOXA5, HOXB6, NOX4, OXT, PKHD1, RHCG, SLC22A12, SLC22A5, SLC34A1, SLC34A3, SLC4A1, SLC7A8, SLC9A4, TRPV4, VDR	654	homeostatic process
GO:0016338	1.066e-02	0.3365	4 CLDN10, CLDN16, CLDN19, CLDN8	16	calcium-independent cell-cell adhesion
GO:0015837	1.103e-02	2.629	10 OXT, RHCG, SLC18A1, SLC22A4, SLC22A5, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9	125	amine transport
GO:0048513	1.141e-02	31.8	51 AFP, ALOX12, AQP6, BPGM, CALCR, COL4A3, CYP27B1, DMRT2, EGF, ELF5, EVC, FOXI1, GCM1, HMX2, HNF1B, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, IL12B, KL, KRT3, NHS, NOX4, NTRK1, OXT, PAX2, PAX8, PKHD1, PLAU, PRLR, REN, RHCG, SCIN, SLC12A6, SLC6A4, TAL2, TFAP2A, TFCP2L1, UPK2, VAV3, VDR	1512	organ development
GO:0043009	1.284e-02	6.645	17 CUBN, DAB2, GCM1, HNF1B, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC6, HOXD10, HOXD3, HOXD4, HOXD9, TFAP2A	316	chordate embryonic development
GO:0009792	1.400e-02	6.709	17 CUBN, DAB2, GCM1, HNF1B, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC6, HOXD10, HOXD3, HOXD4, HOXD9, TFAP2A	319	embryo development ending in birth or egg hatching
GO:0009790	1.459e-02	10.68	23 CUBN, DAB2, FOXI1, GCM1, HMX2, HNF1B, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC6, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, TFAP2A, TINAG	508	embryo development
GO:0003074	1.508e-02	0.04206	2 BTC, OXT	2	regulation of diuresis
GO:0042221	1.549e-02	24.18	41 AFP, ALOX12, AQP2, ARSB, CALCR, CASR, CDH3, COL4A3, CUBN, CYP24A1, CYP27B1, DEFB4A, F2RL1, FMO1, FMO4, GATA3, HNF1B, HSD11B2, HTR1D, MAT2A, OLR1, OXT, PLAU, REN, SCNN1B, SCNN1G, SLC15A2, SLC18A1, SLC22A12, SLC22A5, SLC22A6, SLC22A8, SLC34A1, SLC34A3, SLC6A19, SLC6A4, SLC7A8, TRPM6, UCN3, VDR, WNT9B	1150	response to chemical stimulus
GO:0015893	1.602e-02	0.1682	3 SLC15A2, SLC18A1, SLC22A5	8	drug transport
GO:0009653	1.674e-02	21.93	38 AFP, AQP6, CASR, COL4A3, DAB2, EGF, FOXI1, GATA3, GCM1, HMX2, HNF1B, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, NOX4, PARD6B, PAX2, PAX8, PKHD1, PLAU, SLC12A6, TFAP2A, TFCP2L1, TINAG, VAV3, VDR	1043	anatomical structure morphogenesis
GO:0048731	1.778e-02	41.89	62 AFP, ALOX12, AQP6, ARSB, BPGM, CALCR, COL4A3, CYP27B1, DMRT2, EGF, ELF5, EVC, FOXI1, GCM1, HMX2, HNF1B, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, IL12B, KL, KRT3, NHS, NOX4, NTRK1, OXT, PARD6B, PAX2, PAX8, PKHD1, PLAU, PRLR, REN, RHCG, SCIN, SIM1, SIM2, SLC12A6, SLC6A4, SOX14, TAL2, TFAP2A, TFAP2B, TFCP2L1, TINAG, UPK2, VAV3, VDR, WNT9B	1992	system development
GO:0050878	1.880e-02	3.386	11 AGR2, AQP2, BTC, F2RL1, HSD11B2, OXT, PLAU, PRLR, SLC22A2, SLC22A4, VDR	161	regulation of body fluid levels
GO:0007565	2.019e-02	1.914	8 AQP2, CYP27B1, HSD11B2, OXT, PLAU, PRLR, TFCP2L1, VDR	91	female pregnancy
GO:0032502	2.067e-02	54.59	76 AFP, ALOX12, AQP2, AQP6, ARSB, BICC1, BPGM, BTC, CALCR, CASR, COL4A3, CUBN, CYP24A1, CYP27B1, DAB2, DMRT2, EGF, ELF5, EVC, FOXI1, GATA3, GCM1, HMX2, HNF1B, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB6, HOXB7, HOXC10, HOXC6, HOXC8, HOXC9, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, IL12B, INSRR, KL, KRT3, NHS, NOX4, NTRK1, OXT, PAQR5, PARD6B, PAX2, PAX8, PKHD1, PLAU, PRLR, REN, RHCG, SCIN, SHISA2, SIM1, SIM2, SLC12A6, SLC6A4, SLCO4C1, SOX14, TAL2, TFAP2A, TFAP2B, TFCP2L1, TINAG, UPK2, VAV3, VDR, WNT9B	2596	developmental process
GO:0007275	2.118e-02	50.18	71 AFP, ALOX12, AQP6, ARSB, BICC1, BPGM, CALCR, COL4A3, CUBN, CYP27B1, DAB2, DMRT2, EGF, ELF5, EVC, FOXI1, GCM1, HMX2, HNF1B, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB6, HOXB7, HOXC10, HOXC6, HOXC8, HOXC9, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, IL12B, INSRR, KL, KRT3, NHS, NOX4, NTRK1, OXT, PAQR5, PARD6B, PAX2, PAX8, PKHD1, PLAU, PRLR, REN, RHCG, SCIN, SHISA2, SIM1, SIM2, SLC12A6, SLC6A4, SLCO4C1, SOX14, TAL2, TFAP2A, TFAP2B, TFCP2L1, TINAG, UPK2, VAV3, VDR, WNT9B	2386	multicellular organismal development
GO:0071295	2.163e-02	0.4206	4 CYP24A1, CYP27B1, VDR, WNT9B	20	cellular response to vitamin
GO:0060429	2.318e-02	5.846	15 ALOX12, CYP27B1, ELF5, GCM1, HNF1B, HOXA5, HOXA7, HOXB5, KRT3, PAX2, RHCG, TFAP2A, TFCP2L1, UPK2, VDR	278	epithelium development
GO:0009954	2.499e-02	0.4416	4 HOXA10, HOXC10, HOXD10, HOXD9	21	proximal/distal pattern formation
GO:0048856	2.616e-02	45.36	65 AFP, ALOX12, AQP6, ARSB, BPGM, CALCR, CASR, COL4A3, CYP27B1, DAB2, DMRT2, EGF, ELF5, EVC, FOXI1, GATA3, GCM1, HMX2, HNF1B, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXB5, HOXB6, HOXB7, HOXC10, HOXC6, HOXC8, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, IL12B, KL, KRT3, NHS, NOX4, NTRK1, OXT, PARD6B, PAX2, PAX8, PKHD1, PLAU, PRLR, REN, RHCG, SCIN, SIM1, SIM2, SLC12A6, SLC6A4, SOX14, TAL2, TFAP2A, TFAP2B, TFCP2L1, TINAG, UPK2, VAV3, VDR, WNT9B	2157	anatomical structure development
GO:0031667	2.691e-02	4.164	12 AQP2, ARSB, CUBN, CYP24A1, CYP27B1, HSD11B2, OXT, SLC34A3, SLC6A19, UCN3, VDR, WNT9B	198	response to nutrient levels
GO:0001503	2.777e-02	3.07	10 ATP6V0A4, ATP6V1B1, CALCR, CASR, CYP24A1, CYP27B1, HOXA2, KL, OXT, TFAP2A	146	ossification
GO:0010979	3.336e-02	0.06309	2 CYP27B1, VDR	3	regulation of vitamin D 24-hydroxylase activity
GO:0010980	3.336e-02	0.06309	2 CYP27B1, VDR	3	positive regulation of vitamin D 24-hydroxylase activity
GO:0021794	3.336e-02	0.06309	2 SLC6A4, TAL2	3	thalamus development
GO:0050801	3.459e-02	7.487	17 ALOX12, ATP6V0A4, ATP6V1B1, CALCR, CASR, CLDN16, CYP27B1, F2RL1, OXT, RHCG, SLC34A1, SLC34A3, SLC4A1, SLC7A8, SLC9A4, TRPV4, VDR	356	ion homeostasis
GO:0015698	3.551e-02	0.8412	5 SLC13A1, SLC26A7, SLC34A1, SLC34A3, WNK4	40	inorganic anion transport
GO:0003008	4.011e-02	20.99	35 AQP2, AQP6, ATP6V0A4, ATP6V1B1, BTC, CDH3, CLCNKA, CLDN16, CLDN19, COCH, COL4A3, DAB2, HOXA5, HOXC10, HOXD10, HSD11B2, HTR1D, IL12B, KCNJ1, MYO3B, NPHS2, OLR1, OR10Q1, OR51E1, OXT, PAX2, REN, SCNN1A, SCNN1B, SCNN1G, SCTR, SLC22A5, SLC6A4, USH1C, VDR	998	system process
GO:0031670	4.051e-02	0.5257	4 CYP24A1, CYP27B1, VDR, WNT9B	25	cellular response to nutrient
GO:0006972	4.149e-02	0.2524	3 AQP2, OXT, TRPV4	12	hyperosmotic response
GO:0009991	4.225e-02	4.479	12 AQP2, ARSB, CUBN, CYP24A1, CYP27B1, HSD11B2, OXT, SLC34A3, SLC6A19, UCN3, VDR, WNT9B	213	response to extracellular stimulus
GO:0055080	4.928e-02	5.215	13 ATP6V0A4, ATP6V1B1, CALCR, CASR, CLDN16, CYP27B1, F2RL1, OXT, RHCG, SLC7A8, SLC9A4, TRPV4, VDR	248	cation homeostasis
GO:0009651	4.960e-02	0.2734	3 AQP2, OXT, TRPV4	13	response to salt stress

Id	Pvalue	ExpCount	Count	Size	Term
GO:0045177	4.733e-17	3.627	30 AQP2, ATP6V0A4, ATP6V0D2, ATP6V1B1, CUBN, DPEP1, EPCAM, LGMN, PARD6B, PKHD1, PROM2, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC12A1, SLC12A3, SLC22A11, SLC22A12, SLC22A4, SLC22A5, SLC34A3, SLC4A9, SLC5A12, SLC5A8, SLC9A4, TRPM6, UMOD, USH1C	170	apical part of cell
GO:0016324	1.181e-15	2.881	26 AQP2, ATP6V0A4, ATP6V0D2, ATP6V1B1, CUBN, DPEP1, EPCAM, PKHD1, PROM2, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC12A1, SLC12A3, SLC22A11, SLC22A12, SLC22A4, SLC22A5, SLC34A3, SLC5A12, SLC5A8, SLC9A4, TRPM6, UMOD	135	apical plasma membrane
GO:0005886	1.421e-10	55.99	105 ABCC4, ALOX12, AQP2, AQP6, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSND, BTC, CALCR, CASR, CDCP1, CDH16, CDH3, CLCNKA, CLDN10, CLDN16, CLDN19, CLDN8, CUBN, DPEP1, EGF, EPCAM, F2RL1, FGFBP1, GP2, GPR110, GPR160, GPR172B, GPRC6A, HTR1D, ILDR1, INSRR, KCNJ1, KCNJ16, KL, MME, NOX4, NPHS2, NTRK1, OLR1, OR10Q1, OR51E1, OXGR1, PARD6B, PKHD1, PLA2G3, PLAU, PROM2, RAB19, RAB25, RAB7L1, RHCG, SCNN1A, SCNN1B, SCNN1G, SCTR, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC26A7, SLC34A1, SLC34A3, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A8, SLC7A9, SLC9A4, SLCO4C1, STARD8, STRA6, TAAR2, TMPRSS2, TNFSF15, TRPM6, TRPV4, UMOD, UPK2, VAV3, WNK4, XPNPEP2	2624	plasma membrane
GO:0044459	1.896e-10	33.97	76 AQP2, AQP6, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CALCR, CASR, CDH3, CLCNKA, CLDN10, CLDN16, CLDN19, CLDN8, CUBN, DPEP1, EPCAM, F2RL1, GPR172B, HTR1D, INSRR, KCNJ1, KCNJ16, KL, MME, NOX4, NPHS2, NTRK1, OLR1, PARD6B, PKHD1, PROM2, RAB25, RHCG, SCNN1A, SCNN1B, SCNN1G, SCTR, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A3, SLC15A2, SLC16A4, SLC17A3, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC26A7, SLC34A1, SLC34A3, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A8, SLC7A9, SLC9A4, SLCO4C1, STARD8, TMPRSS2, TNFSF15, TRPM6, TRPV4, UMOD, UPK2, WNK4	1592	plasma membrane part
GO:0031224	1.868e-09	79.31	129 ABCC4, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, BSND, BTC, C12orf59, C17orf78, C9orf71, CA12, CALCR, CASR, CD164L2, CDCP1, CDH16, CDH3, CLCNKA, CLDN10, CLDN16, CLDN19, CLDN8, CWH43, DPEP1, EGF, EPCAM, EVC, EVC2, F2RL1, FMO1, FMO4, GALNT11, GALNT14, GP2, GPR110, GPR160, GPR172B, GPRC6A, GYLTL1B, HTR1D, ILDR1, INSRR, KCNJ1, KCNJ16, KL, KLHDC7A, LRRC19, MME, MS4A10, MSLNL, NOX4, NPHS2, NTRK1, OLR1, OR10Q1, OR51E1, OXGR1, PAQR5, PDZK1IP1, PKHD1, PRLR, PROM2, PTPLAD2, RHCG, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SHISA2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A3, SLC25A45, SLC26A7, SLC34A1, SLC34A3, SLC44A3, SLC44A4, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9, SLC9A4, SLCO4C1, STRA6, TAAR2, TMEM171, TMEM174, TMEM27, TMEM72, TMIGD1, TMPRSS13, TMPRSS2, TNFSF15, TRPM6, TRPV4, TSPAN1, UMOD, UPK2, XPNPEP2	3717	intrinsic to membrane
GO:0016021	1.027e-08	77.63	125 ABCC4, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, BSND, BTC, C12orf59, C17orf78, C9orf71, CA12, CALCR, CASR, CD164L2, CDCP1, CDH16, CDH3, CLCNKA, CLDN10, CLDN16, CLDN19, CLDN8, CWH43, EGF, EPCAM, EVC, EVC2, F2RL1, FMO1, FMO4, GALNT11, GALNT14, GPR110, GPR160, GPR172B, GPRC6A, GYLTL1B, HTR1D, ILDR1, INSRR, KCNJ1, KCNJ16, KL, KLHDC7A, LRRC19, MME, MS4A10, MSLNL, NOX4, NPHS2, NTRK1, OLR1, OR10Q1, OR51E1, OXGR1, PAQR5, PDZK1IP1, PKHD1, PRLR, PROM2, PTPLAD2, RHCG, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SHISA2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A3, SLC25A45, SLC26A7, SLC34A1, SLC34A3, SLC44A3, SLC44A4, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9, SLC9A4, SLCO4C1, STRA6, TAAR2, TMEM171, TMEM174, TMEM27, TMEM72, TMIGD1, TMPRSS13, TMPRSS2, TNFSF15, TRPM6, TRPV4, TSPAN1, UPK2	3638	integral to membrane
GO:0044425	2.083e-08	91.48	139 ABCC4, AP1S3, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSND, BTC, C12orf59, C17orf78, C9orf71, CA12, CALCR, CASR, CD164L2, CDCP1, CDH16, CDH3, CLCNKA, CLDN10, CLDN16, CLDN19, CLDN8, CUBN, CWH43, DAB2, DPEP1, EGF, EPCAM, EVC, EVC2, F2RL1, FMO1, FMO4, GALNT11, GALNT14, GP2, GPR110, GPR160, GPR172B, GPRC6A, GYLTL1B, HTR1D, ILDR1, INSRR, KCNJ1, KCNJ16, KL, KLHDC7A, LRRC19, MME, MS4A10, MSLNL, NOX4, NPHS2, NTRK1, OLR1, OR10Q1, OR51E1, OXGR1, PAQR5, PARD6B, PDZK1IP1, PKHD1, PRLR, PROM2, PTPLAD2, RAB25, RHCG, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SHISA2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A3, SLC25A45, SLC26A7, SLC34A1, SLC34A3, SLC44A3, SLC44A4, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9, SLC9A4, SLCO4C1, STARD8, STRA6, TAAR2, TMEM171, TMEM174, TMEM27, TMEM72, TMIGD1, TMPRSS13, TMPRSS2, TNFSF15, TRPM6, TRPV4, TSPAN1, UMOD, UPK2, WNK4, XPNPEP2	4287	membrane part
GO:0016020	6.769e-07	109.8	153 ABCC4, ALOX12, AP1S3, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSND, BTC, C12orf59, C17orf78, C9orf71, CA12, CALCR, CASR, CD164L2, CDCP1, CDH16, CDH3, CLCNKA, CLDN10, CLDN16, CLDN19, CLDN8, CLINT1, CUBN, CWH43, CYP24A1, CYP27B1, DAB2, DPEP1, EGF, EPCAM, EVC, EVC2, F2RL1, FGFBP1, FMO1, FMO4, GALNT11, GALNT14, GP2, GPR110, GPR160, GPR172B, GPRC6A, GYLTL1B, HTR1D, IL12B, ILDR1, INSRR, KCNJ1, KCNJ16, KL, KLHDC7A, LRRC19, MME, MS4A10, MSLNL, NOX4, NPHS2, NTRK1, OLR1, OR10Q1, OR51E1, OXGR1, PAQR5, PARD6B, PDZK1IP1, PKHD1, PLA2G3, PLA2G4F, PLAU, PRLR, PROM2, PTPLAD2, RAB19, RAB25, RAB7L1, REN, RHCG, SCNN1A, SCNN1B, SCNN1G, SCTR, SFXN2, SHISA2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A3, SLC25A45, SLC26A7, SLC34A1, SLC34A3, SLC44A3, SLC44A4, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9, SLC9A4, SLCO4C1, STARD8, STRA6, TAAR2, TFCP2L1, TMEM171, TMEM174, TMEM27, TMEM72, TMIGD1, TMPRSS13, TMPRSS2, TNFSF15, TRPM6, TRPV4, TSPAN1, UMOD, UPK2, VAV3, WNK4, XPNPEP2	5148	membrane
GO:0016323	5.354e-06	4.097	18 AQP2, ATP6V1B1, BSND, CLDN19, EPCAM, NOX4, PROM2, RHCG, SLC12A6, SLC22A6, SLC22A8, SLC26A7, SLC4A1, SLC4A9, SLC7A8, SLC9A4, SLCO4C1, STARD8	192	basolateral plasma membrane
GO:0031526	1.580e-05	0.5121	7 ATP6V0A4, CUBN, SLC22A12, SLC22A5, SLC34A1, SLC34A3, TRPM6	24	brush border membrane
GO:0005903	2.269e-05	0.7682	8 ATP6V0A4, CUBN, SLC13A1, SLC22A12, SLC22A5, SLC34A1, SLC34A3, TRPM6	36	brush border
GO:0016471	1.740e-04	0.1494	4 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3	7	vacuolar proton-transporting V-type ATPase complex
GO:0031226	2.155e-04	20.14	41 AQP6, ATP12A, BSND, CALCR, CASR, CLCNKA, F2RL1, GPR172B, HTR1D, INSRR, KCNJ1, KCNJ16, KL, MME, NPHS2, NTRK1, OLR1, PKHD1, RHCG, SCNN1G, SCTR, SLC10A2, SLC12A3, SLC15A2, SLC16A4, SLC17A3, SLC22A11, SLC22A13, SLC22A2, SLC22A4, SLC22A6, SLC22A8, SLC34A1, SLC4A1, SLC6A19, SLC6A4, SLC7A8, SLC7A9, TMPRSS2, TNFSF15, UPK2	944	intrinsic to plasma membrane
GO:0005887	2.938e-04	19.72	40 AQP6, ATP12A, BSND, CALCR, CASR, CLCNKA, F2RL1, GPR172B, HTR1D, INSRR, KCNJ1, KCNJ16, KL, MME, NPHS2, NTRK1, OLR1, RHCG, SCNN1G, SCTR, SLC10A2, SLC12A3, SLC15A2, SLC16A4, SLC17A3, SLC22A11, SLC22A13, SLC22A2, SLC22A4, SLC22A6, SLC22A8, SLC34A1, SLC4A1, SLC6A19, SLC6A4, SLC7A8, SLC7A9, TMPRSS2, TNFSF15, UPK2	924	integral to plasma membrane
GO:0031253	5.198e-04	1.942	10 ATP6V0A4, CUBN, DPEP1, PROM2, RAB25, SLC22A12, SLC22A5, SLC34A1, SLC34A3, TRPM6	91	cell projection membrane
GO:0033176	3.816e-03	0.3201	4 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3	15	proton-transporting V-type ATPase complex
GO:0005923	1.410e-02	1.174	6 CLDN10, CLDN16, CLDN19, CLDN8, PARD6B, WNK4	55	tight junction
GO:0070160	1.410e-02	1.174	6 CLDN10, CLDN16, CLDN19, CLDN8, PARD6B, WNK4	55	occluding junction
GO:0005624	2.756e-02	12.87	24 ABCC4, AQP2, ATP6V1B1, CUBN, FMO1, FMO4, HSD11B2, KL, MME, OLR1, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC15A2, SLC16A4, SLC17A3, SLC18A1, SLC22A2, SLC22A6, SLC22A8, SLC6A4	603	membrane fraction
GO:0043296	2.907e-02	1.387	6 CLDN10, CLDN16, CLDN19, CLDN8, PARD6B, WNK4	65	apical junction complex
GO:0034706	3.236e-02	0.2987	3 SCNN1A, SCNN1B, SCNN1G	14	sodium channel complex
GO:0016327	3.498e-02	1.451	6 CLDN10, CLDN16, CLDN19, CLDN8, PARD6B, WNK4	68	apicolateral plasma membrane
GO:0044463	3.955e-02	6.188	14 ATP6V0A4, CALCR, CUBN, DPEP1, OXT, PKHD1, PROM2, RAB25, SLC22A12, SLC22A5, SLC34A1, SLC34A3, TRPM6, UCN3	290	cell projection part
GO:0005626	4.047e-02	13.36	24 ABCC4, AQP2, ATP6V1B1, CUBN, FMO1, FMO4, HSD11B2, KL, MME, OLR1, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC15A2, SLC16A4, SLC17A3, SLC18A1, SLC22A2, SLC22A6, SLC22A8, SLC6A4	626	insoluble fraction
GO:0016469	4.190e-02	0.6615	4 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3	31	proton-transporting two-sector ATPase complex
GO:0005587	4.451e-02	0.1067	2 COL4A3, COL4A6	5	collagen type IV

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022804	2.967e-17	5.695	38 ABCC4, ATP10D, ATP12A, ATP6V0A4, ATP6V1B1, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC26A7, SLC34A1, SLC34A3, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9, SLC9A4	277	active transmembrane transporter activity
GO:0022857	9.213e-17	14.64	58 ABCC4, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSND, CLCNKA, CLDN16, GPR172B, KCNJ1, KCNJ16, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC26A7, SLC34A1, SLC34A3, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9, SLC9A4, TRPM6, TRPV4	712	transmembrane transporter activity
GO:0015291	2.834e-16	3.289	29 SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC22A11, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC26A7, SLC34A1, SLC34A3, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC9A4	160	secondary active transmembrane transporter activity
GO:0005215	7.055e-16	18.75	64 ABCC4, AP1S3, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSND, CLCNKA, CLDN16, CSN2, CUBN, GPR172B, KCNJ1, KCNJ16, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC23A3, SLC26A7, SLC34A1, SLC34A3, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9, SLC9A4, SLCO4C1, TRPM6, TRPV4	912	transporter activity
GO:0022891	5.706e-13	13.34	49 ABCC4, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCNKA, CLDN16, KCNJ1, KCNJ16, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC16A4, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC26A7, SLC34A1, SLC34A3, SLC4A1, SLC4A9, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9, SLC9A4, TRPM6, TRPV4	649	substrate-specific transmembrane transporter activity
GO:0015293	1.690e-11	2.2	20 SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC17A3, SLC22A4, SLC22A5, SLC34A1, SLC34A3, SLC5A12, SLC5A8, SLC6A19, SLC6A4	107	symporter activity
GO:0015075	2.021e-11	11.62	43 ABCC4, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCNKA, CLDN16, KCNJ1, KCNJ16, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC17A3, SLC22A11, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC26A7, SLC34A1, SLC34A3, SLC4A1, SLC4A9, SLC6A19, SLC6A4, SLC7A8, SLC9A4, TRPM6, TRPV4	565	ion transmembrane transporter activity
GO:0022892	2.665e-11	15.5	50 ABCC4, AP1S3, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCNKA, CLDN16, KCNJ1, KCNJ16, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC16A4, SLC17A3, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC22A6, SLC22A8, SLC26A7, SLC34A1, SLC34A3, SLC4A1, SLC4A9, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9, SLC9A4, TRPM6, TRPV4	754	substrate-specific transporter activity
GO:0008509	5.075e-09	2.426	18 ABCC4, AQP6, BSND, CLCNKA, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC22A11, SLC22A6, SLC22A8, SLC26A7, SLC34A1, SLC34A3, SLC4A1, SLC4A9	118	anion transmembrane transporter activity
GO:0008324	1.678e-07	8.984	31 ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, CLDN16, KCNJ1, KCNJ16, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC17A3, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC34A3, SLC6A19, SLC6A4, SLC7A8, SLC9A4, TRPM6, TRPV4	437	cation transmembrane transporter activity
GO:0015101	5.342e-06	0.2467	6 RHCG, SLC22A13, SLC22A2, SLC22A4, SLC22A5, SLC7A8	12	organic cation transmembrane transporter activity
GO:0043565	6.101e-06	9.457	29 ELF5, FOXI1, GATA3, HMX2, HNF1B, HNF4G, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB6, HOXB7, HOXC10, HOXC6, HOXC8, HOXC9, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, PAX2, PAX8, SOX14, TFAP2B, VDR	460	sequence-specific DNA binding
GO:0015297	1.017e-05	1.11	10 SLC22A11, SLC22A4, SLC22A6, SLC22A8, SLC26A7, SLC47A1, SLC47A2, SLC4A1, SLC4A9, SLC9A4	54	antiporter activity
GO:0015294	2.001e-05	1.501	11 SLC10A2, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC15A2, SLC17A3, SLC34A3, SLC6A19, SLC6A4	73	solute:cation symporter activity
GO:0022890	2.128e-05	3.392	16 ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, CLDN16, RHCG, SLC10A2, SLC13A1, SLC13A3, SLC17A3, SLC22A4, SLC22A5, SLC34A3, SLC6A19, SLC6A4, SLC9A4	165	inorganic cation transmembrane transporter activity
GO:0015380	3.537e-05	0.3289	6 SLC22A11, SLC22A6, SLC22A8, SLC26A7, SLC4A1, SLC4A9	16	anion exchanger activity
GO:0015301	5.157e-05	0.3495	6 SLC22A11, SLC22A6, SLC22A8, SLC26A7, SLC4A1, SLC4A9	17	anion:anion antiporter activity
GO:0003700	7.129e-05	14.56	35 DMRT2, ELF5, FOXI1, GATA3, GCM1, GRHL2, HMX2, HNF1B, HNF4G, HOXA10, HOXA2, HOXA3, HOXA5, HOXA7, HOXA9, HOXB5, HOXB6, HOXB7, HOXC10, HOXC6, HOXC8, HOXC9, HOXD10, HOXD3, HOXD4, HOXD8, HOXD9, PAX8, SIM1, SIM2, TFAP2A, TFAP2B, TFCP2L1, TFEC, VDR	708	sequence-specific DNA binding transcription factor activity
GO:0015300	1.177e-04	0.8635	8 SLC22A11, SLC22A4, SLC22A6, SLC22A8, SLC26A7, SLC4A1, SLC4A9, SLC9A4	42	solute:solute antiporter activity
GO:0015296	1.238e-04	0.6168	7 SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC13A3, SLC17A3, SLC34A3	30	anion:cation symporter activity
GO:0015103	1.526e-04	0.6373	7 AQP6, SLC13A1, SLC17A3, SLC26A7, SLC34A1, SLC34A3, SLC4A1	31	inorganic anion transmembrane transporter activity
GO:0005452	1.535e-04	0.2467	5 SLC22A11, SLC22A6, SLC22A8, SLC4A1, SLC4A9	12	inorganic anion exchanger activity
GO:0015238	1.535e-04	0.2467	5 SLC15A2, SLC18A1, SLC22A5, SLC47A1, SLC47A2	12	drug transmembrane transporter activity
GO:0005275	2.881e-04	1.295	9 SLC13A3, SLC18A1, SLC22A4, SLC22A5, SLC6A19, SLC6A4, SLC7A13, SLC7A8, SLC7A9	63	amine transmembrane transporter activity
GO:0015077	5.385e-04	2.59	12 ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, SLC10A2, SLC13A1, SLC13A3, SLC17A3, SLC34A3, SLC6A19, SLC6A4, SLC9A4	126	monovalent inorganic cation transmembrane transporter activity
GO:0005342	6.766e-04	1.46	9 SLC10A2, SLC13A3, SLC16A4, SLC22A12, SLC26A7, SLC6A19, SLC7A13, SLC7A8, SLC7A9	71	organic acid transmembrane transporter activity
GO:0046943	3.379e-03	1.439	8 SLC10A2, SLC13A3, SLC16A4, SLC26A7, SLC6A19, SLC7A13, SLC7A8, SLC7A9	70	carboxylic acid transmembrane transporter activity
GO:0015280	8.682e-03	0.1439	3 SCNN1A, SCNN1B, SCNN1G	7	amiloride-sensitive sodium channel activity
GO:0016709	9.960e-03	0.3495	4 CYP24A1, CYP27B1, FMO1, FMO4	17	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
GO:0015081	1.136e-02	1.357	7 SLC10A2, SLC13A1, SLC13A3, SLC17A3, SLC34A3, SLC6A19, SLC6A4	66	sodium ion transmembrane transporter activity
GO:0015377	1.258e-02	0.1645	3 SLC12A1, SLC12A3, SLC12A6	8	cation:chloride symporter activity
GO:0046873	1.506e-02	2.344	9 ATP12A, CLDN16, SLC10A2, SLC13A1, SLC13A3, SLC17A3, SLC34A3, SLC6A19, SLC6A4	114	metal ion transmembrane transporter activity
GO:0015226	2.763e-02	0.06168	2 SLC22A4, SLC22A5	3	carnitine transporter activity
GO:0008514	2.769e-02	0.2262	3 SLC22A11, SLC22A6, SLC22A8	11	organic anion transmembrane transporter activity
GO:0005154	3.384e-02	0.2467	3 BTC, EGF, VAV3	12	epidermal growth factor receptor binding
GO:0015114	4.097e-02	0.2673	3 SLC17A3, SLC34A1, SLC34A3	13	phosphate transmembrane transporter activity
GO:0015651	4.624e-02	0.08224	2 SLC22A4, SLC22A5	4	quaternary ammonium group transmembrane transporter activity

Id	Pvalue	ExpCount	Count	Size	Term
04966	1.140e-03	0.3942	5 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, SLC4A1	21	Collecting duct acid secretion
04960	7.905e-03	0.6194	5 HSD11B2, KCNJ1, SCNN1A, SCNN1B, SCNN1G	33	Aldosterone-regulated sodium reabsorption

No enriched terms

No enriched terms

Entrez genes

A2LD1AIG2-like domain 1 (ENSG00000134864), score: 0.6 ABCC4ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ENSG00000125257), score: 0.59 ABP1amiloride binding protein 1 (amine oxidase (copper-containing)) (ENSG00000002726), score: 0.55 ACSF2acyl-CoA synthetase family member 2 (ENSG00000167107), score: 0.53 ACY1aminoacylase 1 (ENSG00000243989), score: 0.53 AFPalpha-fetoprotein (ENSG00000081051), score: 0.68 AGR2anterior gradient homolog 2 (Xenopus laevis) (ENSG00000106541), score: 0.52 AGR3anterior gradient homolog 3 (Xenopus laevis) (ENSG00000173467), score: 1 ALOX12arachidonate 12-lipoxygenase (ENSG00000108839), score: 0.55 AP1S3adaptor-related protein complex 1, sigma 3 subunit (ENSG00000152056), score: 0.55 AQP2aquaporin 2 (collecting duct) (ENSG00000167580), score: 0.6 AQP6aquaporin 6, kidney specific (ENSG00000086159), score: 0.63 ARHGAP18Rho GTPase activating protein 18 (ENSG00000146376), score: 0.52 ARSBarylsulfatase B (ENSG00000113273), score: 0.56 ARSFarylsulfatase F (ENSG00000062096), score: 0.62 ASPAaspartoacylase (ENSG00000108381), score: 0.6 ATP10DATPase, class V, type 10D (ENSG00000145246), score: 0.6 ATP12AATPase, H+/K+ transporting, nongastric, alpha polypeptide (ENSG00000075673), score: 0.56 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.61 ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (ENSG00000147614), score: 0.59 ATP6V1B1ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (ENSG00000116039), score: 0.56 ATP6V1G3ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 (ENSG00000151418), score: 0.62 BICC1bicaudal C homolog 1 (Drosophila) (ENSG00000122870), score: 0.53 BPGM2,3-bisphosphoglycerate mutase (ENSG00000172331), score: 0.52 BSNDBartter syndrome, infantile, with sensorineural deafness (Barttin) (ENSG00000162399), score: 0.64 BTCbetacellulin (ENSG00000174808), score: 0.74 C12orf59chromosome 12 open reading frame 59 (ENSG00000165685), score: 0.62 C17orf78chromosome 17 open reading frame 78 (ENSG00000167230), score: 0.74 C19orf21chromosome 19 open reading frame 21 (ENSG00000099812), score: 0.51 C1orf106chromosome 1 open reading frame 106 (ENSG00000163362), score: 0.59 C1orf116chromosome 1 open reading frame 116 (ENSG00000182795), score: 0.58 C9orf71chromosome 9 open reading frame 71 (ENSG00000181778), score: 0.53 CA12carbonic anhydrase XII (ENSG00000074410), score: 0.57 CA13carbonic anhydrase XIII (ENSG00000185015), score: 0.66 CALCRcalcitonin receptor (ENSG00000004948), score: 0.83 CAPN13calpain 13 (ENSG00000162949), score: 0.53 CASRcalcium-sensing receptor (ENSG00000036828), score: 0.72 CD164L2CD164 sialomucin-like 2 (ENSG00000174950), score: 0.69 CDCP1CUB domain containing protein 1 (ENSG00000163814), score: 0.66 CDH16cadherin 16, KSP-cadherin (ENSG00000166589), score: 0.59 CDH3cadherin 3, type 1, P-cadherin (placental) (ENSG00000062038), score: 0.53 CDKL1cyclin-dependent kinase-like 1 (CDC2-related kinase) (ENSG00000100490), score: 0.55 CLCNKAchloride channel Ka (ENSG00000186510), score: 0.53 CLDN10claudin 10 (ENSG00000134873), score: 0.51 CLDN16claudin 16 (ENSG00000113946), score: 0.77 CLDN19claudin 19 (ENSG00000164007), score: 0.76 CLDN8claudin 8 (ENSG00000156284), score: 0.65 CLINT1clathrin interactor 1 (ENSG00000113282), score: 0.51 CLNKcytokine-dependent hematopoietic cell linker (ENSG00000109684), score: 0.57 COCHcoagulation factor C homolog, cochlin (Limulus polyphemus) (ENSG00000100473), score: 0.54 COL4A3collagen, type IV, alpha 3 (Goodpasture antigen) (ENSG00000169031), score: 0.54 COL4A6collagen, type IV, alpha 6 (ENSG00000197565), score: 0.53 CSN2casein beta (ENSG00000135222), score: 0.71 CUBNcubilin (intrinsic factor-cobalamin receptor) (ENSG00000107611), score: 0.68 CWH43cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) (ENSG00000109182), score: 0.53 CYP24A1cytochrome P450, family 24, subfamily A, polypeptide 1 (ENSG00000019186), score: 0.57 CYP27B1cytochrome P450, family 27, subfamily B, polypeptide 1 (ENSG00000111012), score: 0.54 DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (ENSG00000153071), score: 0.53 DEFB4Bdefensin, beta 4B (ENSG00000171711), score: 0.86 DHDHdihydrodiol dehydrogenase (dimeric) (ENSG00000104808), score: 0.69 DMRT2doublesex and mab-3 related transcription factor 2 (ENSG00000173253), score: 0.54 DOCK8dedicator of cytokinesis 8 (ENSG00000107099), score: 0.64 DPEP1dipeptidase 1 (renal) (ENSG00000015413), score: 0.54 DUSP9dual specificity phosphatase 9 (ENSG00000130829), score: 0.58 EGFepidermal growth factor (ENSG00000138798), score: 0.68 ELF5E74-like factor 5 (ets domain transcription factor) (ENSG00000135374), score: 0.7 EPCAMepithelial cell adhesion molecule (ENSG00000119888), score: 0.57 ESM1endothelial cell-specific molecule 1 (ENSG00000164283), score: 0.62 ESRP1epithelial splicing regulatory protein 1 (ENSG00000104413), score: 0.66 EVCEllis van Creveld syndrome (ENSG00000072840), score: 0.54 EVC2Ellis van Creveld syndrome 2 (ENSG00000173040), score: 0.51 F2RL1coagulation factor II (thrombin) receptor-like 1 (ENSG00000164251), score: 0.62 FAM83Cfamily with sequence similarity 83, member C (ENSG00000125998), score: 0.56 FGFBP1fibroblast growth factor binding protein 1 (ENSG00000137440), score: 0.83 FMO1flavin containing monooxygenase 1 (ENSG00000010932), score: 0.67 FMO4flavin containing monooxygenase 4 (ENSG00000076258), score: 0.55 FOXI1forkhead box I1 (ENSG00000168269), score: 0.62 FRMD1FERM domain containing 1 (ENSG00000153303), score: 0.52 GALNT11UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) (ENSG00000178234), score: 0.59 GALNT14UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) (ENSG00000158089), score: 0.53 GATA3GATA binding protein 3 (ENSG00000107485), score: 0.54 GCM1glial cells missing homolog 1 (Drosophila) (ENSG00000137270), score: 0.78 GIPC2GIPC PDZ domain containing family, member 2 (ENSG00000137960), score: 0.53 GP2glycoprotein 2 (zymogen granule membrane) (ENSG00000169347), score: 0.82 GPR110G protein-coupled receptor 110 (ENSG00000153292), score: 0.58 GPR160G protein-coupled receptor 160 (ENSG00000173890), score: 0.52 GPR172BG protein-coupled receptor 172B (ENSG00000132517), score: 0.51 GPRC6AG protein-coupled receptor, family C, group 6, member A (ENSG00000173612), score: 0.68 GRB7growth factor receptor-bound protein 7 (ENSG00000141738), score: 0.54 GRHL2grainyhead-like 2 (Drosophila) (ENSG00000083307), score: 0.66 GYLTL1Bglycosyltransferase-like 1B (ENSG00000165905), score: 0.62 HMX2H6 family homeobox 2 (ENSG00000188816), score: 0.66 HNF1BHNF1 homeobox B (ENSG00000108753), score: 0.53 HNF4Ghepatocyte nuclear factor 4, gamma (ENSG00000164749), score: 0.59 HOXA10homeobox A10 (ENSG00000153807), score: 0.63 HOXA2homeobox A2 (ENSG00000105996), score: 0.62 HOXA3homeobox A3 (ENSG00000105997), score: 0.57 HOXA5homeobox A5 (ENSG00000106004), score: 0.6 HOXA7homeobox A7 (ENSG00000122592), score: 0.53 HOXA9homeobox A9 (ENSG00000078399), score: 0.64 HOXB5homeobox B5 (ENSG00000120075), score: 0.63 HOXB6homeobox B6 (ENSG00000108511), score: 0.6 HOXB7homeobox B7 (ENSG00000120087), score: 0.62 HOXC10homeobox C10 (ENSG00000180818), score: 0.63 HOXC6homeobox C6 (ENSG00000197757), score: 0.59 HOXC8homeobox C8 (ENSG00000037965), score: 0.62 HOXC9homeobox C9 (ENSG00000180806), score: 0.57 HOXD10homeobox D10 (ENSG00000128710), score: 0.62 HOXD3homeobox D3 (ENSG00000128652), score: 0.59 HOXD4homeobox D4 (ENSG00000170166), score: 0.64 HOXD8homeobox D8 (ENSG00000175879), score: 0.53 HOXD9homeobox D9 (ENSG00000128709), score: 0.54 HSD11B2hydroxysteroid (11-beta) dehydrogenase 2 (ENSG00000176387), score: 0.63 HTR1D5-hydroxytryptamine (serotonin) receptor 1D (ENSG00000179546), score: 0.71 IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (ENSG00000113302), score: 0.65 ILDR1immunoglobulin-like domain containing receptor 1 (ENSG00000145103), score: 0.54 INSRRinsulin receptor-related receptor (ENSG00000027644), score: 0.62 IVNS1ABPinfluenza virus NS1A binding protein (ENSG00000116679), score: 0.6 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.62 KCNJ16potassium inwardly-rectifying channel, subfamily J, member 16 (ENSG00000153822), score: 0.57 KLklotho (ENSG00000133116), score: 0.67 KLF8Kruppel-like factor 8 (ENSG00000102349), score: 0.57 KLHDC7Akelch domain containing 7A (ENSG00000179023), score: 0.51 KRT3keratin 3 (ENSG00000186442), score: 0.71 LAMB4laminin, beta 4 (ENSG00000091128), score: 0.81 LGALS2lectin, galactoside-binding, soluble, 2 (ENSG00000100079), score: 0.56 LGMNlegumain (ENSG00000100600), score: 0.51 LRRC19leucine rich repeat containing 19 (ENSG00000184434), score: 0.71 MACC1metastasis associated in colon cancer 1 (ENSG00000183742), score: 0.58 MAT2Amethionine adenosyltransferase II, alpha (ENSG00000168906), score: 0.53 MCCD1mitochondrial coiled-coil domain 1 (ENSG00000204511), score: 0.54 MCM10minichromosome maintenance complex component 10 (ENSG00000065328), score: 0.52 MIOXmyo-inositol oxygenase (ENSG00000100253), score: 0.62 MMEmembrane metallo-endopeptidase (ENSG00000196549), score: 0.55 MMP13matrix metallopeptidase 13 (collagenase 3) (ENSG00000137745), score: 0.59 MOBKL2BMOB1, Mps One Binder kinase activator-like 2B (yeast) (ENSG00000120162), score: 0.55 MROmaestro (ENSG00000134042), score: 0.52 MS4A10membrane-spanning 4-domains, subfamily A, member 10 (ENSG00000172689), score: 0.94 MSLNLmesothelin-like (ENSG00000162006), score: 0.61 MTMR8myotubularin related protein 8 (ENSG00000102043), score: 0.7 MYO3Bmyosin IIIB (ENSG00000071909), score: 0.62 NARFnuclear prelamin A recognition factor (ENSG00000141562), score: -0.63 NET1neuroepithelial cell transforming 1 (ENSG00000173848), score: 0.6 NHSNance-Horan syndrome (congenital cataracts and dental anomalies) (ENSG00000188158), score: 0.69 NOX4NADPH oxidase 4 (ENSG00000086991), score: 0.61 NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin) (ENSG00000116218), score: 0.56 NTRK1neurotrophic tyrosine kinase, receptor, type 1 (ENSG00000198400), score: 0.54 OLR1oxidized low density lipoprotein (lectin-like) receptor 1 (ENSG00000173391), score: 0.55 OR10Q1olfactory receptor, family 10, subfamily Q, member 1 (ENSG00000180475), score: 0.65 OR51E1olfactory receptor, family 51, subfamily E, member 1 (ENSG00000180785), score: 0.56 OXGR1oxoglutarate (alpha-ketoglutarate) receptor 1 (ENSG00000165621), score: 0.74 OXToxytocin, prepropeptide (ENSG00000101405), score: 0.56 PAPLNpapilin, proteoglycan-like sulfated glycoprotein (ENSG00000100767), score: 0.54 PAQR5progestin and adipoQ receptor family member V (ENSG00000137819), score: 0.58 PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans) (ENSG00000124171), score: 0.65 PAX2paired box 2 (ENSG00000075891), score: 0.62 PAX8paired box 8 (ENSG00000125618), score: 0.56 PDZK1IP1PDZK1 interacting protein 1 (ENSG00000162366), score: 0.55 PKHD1polycystic kidney and hepatic disease 1 (autosomal recessive) (ENSG00000170927), score: 0.69 PLA2G3phospholipase A2, group III (ENSG00000100078), score: 0.79 PLA2G4Fphospholipase A2, group IVF (ENSG00000168907), score: 0.53 PLAUplasminogen activator, urokinase (ENSG00000122861), score: 0.52 PNPLA1patatin-like phospholipase domain containing 1 (ENSG00000180316), score: 0.78 PPP1R14Dprotein phosphatase 1, regulatory (inhibitor) subunit 14D (ENSG00000166143), score: 0.52 PRLRprolactin receptor (ENSG00000113494), score: 0.62 PROM2prominin 2 (ENSG00000155066), score: 0.62 PRR15Lproline rich 15-like (ENSG00000167183), score: 0.51 PTPLAD2protein tyrosine phosphatase-like A domain containing 2 (ENSG00000188921), score: 0.8 RAB19RAB19, member RAS oncogene family (ENSG00000146955), score: 0.67 RAB25RAB25, member RAS oncogene family (ENSG00000132698), score: 0.54 RAB7L1RAB7, member RAS oncogene family-like 1 (ENSG00000117280), score: 0.58 RENrenin (ENSG00000143839), score: 0.65 RHCGRh family, C glycoprotein (ENSG00000140519), score: 0.52 SCINscinderin (ENSG00000006747), score: 0.54 SCNN1Asodium channel, nonvoltage-gated 1 alpha (ENSG00000111319), score: 0.53 SCNN1Bsodium channel, nonvoltage-gated 1, beta (ENSG00000168447), score: 0.52 SCNN1Gsodium channel, nonvoltage-gated 1, gamma (ENSG00000166828), score: 0.53 SCTRsecretin receptor (ENSG00000080293), score: 0.62 SFXN2sideroflexin 2 (ENSG00000156398), score: 0.53 SHISA2shisa homolog 2 (Xenopus laevis) (ENSG00000180730), score: 0.53 SIM1single-minded homolog 1 (Drosophila) (ENSG00000112246), score: 0.71 SIM2single-minded homolog 2 (Drosophila) (ENSG00000159263), score: 0.56 SLC10A2solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (ENSG00000125255), score: 0.66 SLC12A1solute carrier family 12 (sodium/potassium/chloride transporters), member 1 (ENSG00000074803), score: 0.67 SLC12A3solute carrier family 12 (sodium/chloride transporters), member 3 (ENSG00000070915), score: 0.64 SLC12A6solute carrier family 12 (potassium/chloride transporters), member 6 (ENSG00000140199), score: 0.53 SLC13A1solute carrier family 13 (sodium/sulfate symporters), member 1 (ENSG00000081800), score: 0.59 SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (ENSG00000158296), score: 0.55 SLC15A2solute carrier family 15 (H+/peptide transporter), member 2 (ENSG00000163406), score: 0.6 SLC15A5solute carrier family 15, member 5 (ENSG00000188991), score: 0.8 SLC16A12solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (ENSG00000152779), score: 0.57 SLC16A4solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (ENSG00000168679), score: 0.64 SLC16A9solute carrier family 16, member 9 (monocarboxylic acid transporter 9) (ENSG00000165449), score: 0.7 SLC17A3solute carrier family 17 (sodium phosphate), member 3 (ENSG00000124564), score: 0.55 SLC18A1solute carrier family 18 (vesicular monoamine), member 1 (ENSG00000036565), score: 0.51 SLC22A11solute carrier family 22 (organic anion/urate transporter), member 11 (ENSG00000168065), score: 0.63 SLC22A12solute carrier family 22 (organic anion/urate transporter), member 12 (ENSG00000197891), score: 0.62 SLC22A13solute carrier family 22 (organic anion transporter), member 13 (ENSG00000172940), score: 0.61 SLC22A2solute carrier family 22 (organic cation transporter), member 2 (ENSG00000112499), score: 0.67 SLC22A4solute carrier family 22 (organic cation/ergothioneine transporter), member 4 (ENSG00000197208), score: 0.59 SLC22A5solute carrier family 22 (organic cation/carnitine transporter), member 5 (ENSG00000197375), score: 0.56 SLC22A6solute carrier family 22 (organic anion transporter), member 6 (ENSG00000197901), score: 0.59 SLC22A8solute carrier family 22 (organic anion transporter), member 8 (ENSG00000149452), score: 0.56 SLC23A3solute carrier family 23 (nucleobase transporters), member 3 (ENSG00000213901), score: 0.61 SLC25A45solute carrier family 25, member 45 (ENSG00000162241), score: 0.56 SLC26A7solute carrier family 26, member 7 (ENSG00000147606), score: 0.73 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 0.63 SLC34A3solute carrier family 34 (sodium phosphate), member 3 (ENSG00000198569), score: 0.59 SLC44A3solute carrier family 44, member 3 (ENSG00000143036), score: 0.52 SLC44A4solute carrier family 44, member 4 (ENSG00000204385), score: 0.57 SLC47A1solute carrier family 47, member 1 (ENSG00000142494), score: 0.52 SLC47A2solute carrier family 47, member 2 (ENSG00000180638), score: 0.62 SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (ENSG00000004939), score: 0.6 SLC4A9solute carrier family 4, sodium bicarbonate cotransporter, member 9 (ENSG00000113073), score: 0.6 SLC5A10solute carrier family 5 (sodium/glucose cotransporter), member 10 (ENSG00000154025), score: 0.53 SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12 (ENSG00000148942), score: 0.62 SLC5A8solute carrier family 5 (iodide transporter), member 8 (ENSG00000139357), score: 0.7 SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19 (ENSG00000174358), score: 0.67 SLC6A4solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (ENSG00000108576), score: 0.66 SLC7A13solute carrier family 7, (cationic amino acid transporter, y+ system) member 13 (ENSG00000164893), score: 0.9 SLC7A8solute carrier family 7 (amino acid transporter, L-type), member 8 (ENSG00000092068), score: 0.52 SLC7A9solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 (ENSG00000021488), score: 0.52 SLC9A4solute carrier family 9 (sodium/hydrogen exchanger), member 4 (ENSG00000180251), score: 0.6 SLCO4C1solute carrier organic anion transporter family, member 4C1 (ENSG00000173930), score: 0.62 SMTNL2smoothelin-like 2 (ENSG00000188176), score: 0.52 SNX29sorting nexin 29 (ENSG00000048471), score: 0.52 SOX14SRY (sex determining region Y)-box 14 (ENSG00000168875), score: 0.6 STARD8StAR-related lipid transfer (START) domain containing 8 (ENSG00000130052), score: 0.52 STRA6stimulated by retinoic acid gene 6 homolog (mouse) (ENSG00000137868), score: 0.59 SULT1C2sulfotransferase family, cytosolic, 1C, member 2 (ENSG00000198203), score: 0.59 TAAR2trace amine associated receptor 2 (ENSG00000146378), score: 0.53 TAL2T-cell acute lymphocytic leukemia 2 (ENSG00000186051), score: 0.61 TCN2transcobalamin II (ENSG00000185339), score: 0.56 TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (ENSG00000137203), score: 0.56 TFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta) (ENSG00000008196), score: 0.59 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.59 TFECtranscription factor EC (ENSG00000105967), score: 0.83 TINAGtubulointerstitial nephritis antigen (ENSG00000137251), score: 0.67 TMEM171transmembrane protein 171 (ENSG00000157111), score: 0.51 TMEM174transmembrane protein 174 (ENSG00000164325), score: 0.59 TMEM27transmembrane protein 27 (ENSG00000147003), score: 0.57 TMEM72transmembrane protein 72 (ENSG00000187783), score: 0.64 TMIGD1transmembrane and immunoglobulin domain containing 1 (ENSG00000182271), score: 0.94 TMPRSS13transmembrane protease, serine 13 (ENSG00000137747), score: 0.66 TMPRSS2transmembrane protease, serine 2 (ENSG00000184012), score: 0.51 TNFSF15tumor necrosis factor (ligand) superfamily, member 15 (ENSG00000181634), score: 0.87 TRPM6transient receptor potential cation channel, subfamily M, member 6 (ENSG00000119121), score: 0.59 TRPV4transient receptor potential cation channel, subfamily V, member 4 (ENSG00000111199), score: 0.59 TSPAN1tetraspanin 1 (ENSG00000117472), score: 0.51 UCN3urocortin 3 (stresscopin) (ENSG00000178473), score: 0.88 UMODuromodulin (ENSG00000169344), score: 0.66 UPK2uroplakin 2 (ENSG00000110375), score: 0.63 USH1CUsher syndrome 1C (autosomal recessive, severe) (ENSG00000006611), score: 0.52 VAV3vav 3 guanine nucleotide exchange factor (ENSG00000134215), score: 0.53 VDRvitamin D (1,25- dihydroxyvitamin D3) receptor (ENSG00000111424), score: 0.62 WNK4WNK lysine deficient protein kinase 4 (ENSG00000126562), score: 0.57 WNT9Bwingless-type MMTV integration site family, member 9B (ENSG00000158955), score: 0.57 XPCxeroderma pigmentosum, complementation group C (ENSG00000154767), score: 0.6 XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (ENSG00000122121), score: 0.59 ZNF618zinc finger protein 618 (ENSG00000157657), score: 0.52

Non-Entrez genes

ENSG00000203799Unknown, score: 0.58 ENSG00000163814Unknown, score: 0.51 ENSG00000137960Unknown, score: 0.54

Id	species	tissue	sex	individual
ptr_kd_m_ca1	ptr	kd	m	_
ppy_kd_m_ca1	ppy	kd	m	_
mml_kd_f_ca1	mml	kd	f	_
mml_kd_m_ca1	mml	kd	m	_