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metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

immune effector process

Any process of the immune system that occurs as part of an immune response.

activation of immune response

Any process that initiates an immune response.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

leukocyte mediated immunity

Any process involved in the carrying out of an immune response by a leukocyte.

lymphocyte mediated immunity

Any process involved in the carrying out of an immune response by a lymphocyte.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

carbohydrate metabolic process

The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.

polysaccharide metabolic process

The chemical reactions and pathways involving polysaccharides, a polymer of more than 20 monosaccharide residues joined by glycosidic linkages.

aminoglycan metabolic process

The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.

alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

protein maturation by peptide bond cleavage

The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

cellular aromatic compound metabolic process

The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

lipid transport

The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

humoral immune response

An immune response mediated through a body fluid.

digestion

The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

hemostasis

The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

cell death

A biological process that results in permanent cessation of all vital functions of a cell.

cytolysis

The rupture of cell membranes and the loss of cytoplasm.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

gene expression

The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of hormone levels

Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.

lipid localization

Any process by which a lipid is transported to, or maintained in, a specific location.

sterol transport

The directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

death

A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.

protein processing

Any protein maturation process achieved by the cleavage of peptide bonds.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

carboxylic acid metabolic process

The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

digestive system process

A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

glycosaminoglycan metabolic process

The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties.

hyaluronan metabolic process

The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.

intestinal cholesterol absorption

Uptake of cholesterol into the blood by absorption from the small intestine.

cholesterol transport

The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells by means of some external agent such as a transporter or pore.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

negative regulation of cellular protein metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

macromolecule localization

Any process by which a macromolecule is transported to, or maintained in, a specific location.

plasma lipoprotein oxidation

The modification of a lipoprotein by oxidation of one or more amino acids or the lipid moiety, occurring in the blood plasma.

regulation of lipoprotein oxidation

Any process that modulates the frequency, rate or extent of lipoprotein oxidation.

negative regulation of lipoprotein oxidation

Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation.

regulation of plasma lipoprotein oxidation

Any process that modulates the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma.

negative regulation of plasma lipoprotein oxidation

Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular hormone metabolic process

The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

lipoprotein metabolic process

The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.

lipoprotein modification

The chemical reactions and pathways resulting in the covalent alteration of one or more amino acid or lipid residues occurring in a lipoprotein, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.

lipoprotein oxidation

The modification of a lipoprotein by oxidation of one or more amino acids or the lipid moiety.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

hormone metabolic process

The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.

homeostatic process

Any biological process involved in the maintenance of an internal steady-state.

cholesterol homeostasis

Any process involved in the maintenance of an internal steady-state of cholesterol within an organism or cell.

fibrinolysis

An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

cellular amide metabolic process

The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.

amide biosynthetic process

The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

lipid digestion

The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

cellular nitrogen compound biosynthetic process

The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

chemical homeostasis

Any biological process involved in the maintenance of an internal steady-state of a chemical.

regulation of lipoprotein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.

negative regulation of lipoprotein metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

coagulation

The process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

regulation of coagulation

Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

positive regulation of coagulation

Any process that activates or increases the frequency, rate or extent of coagulation.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

intestinal absorption

Any process by which nutrients are taken up from the contents of the intestine.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

negative regulation of protein metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

regulation of fibrinolysis

Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

negative regulation of fibrinolysis

Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

lipid homeostasis

Any process involved in the maintenance of an internal steady-state of lipid within an organism or cell.

sterol homeostasis

Any process involved in the maintenance of an internal steady-state of sterol within an organism or cell.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of wound healing

Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

regulation of primary metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

regulation of response to stress

Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

all

NA

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

cell death

A biological process that results in permanent cessation of all vital functions of a cell.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular hormone metabolic process

The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

regulation of primary metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

immune effector process

Any process of the immune system that occurs as part of an immune response.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

digestive system process

A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

regulation of coagulation

Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

positive regulation of coagulation

Any process that activates or increases the frequency, rate or extent of coagulation.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

negative regulation of fibrinolysis

Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

regulation of response to stress

Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

cellular nitrogen compound biosynthetic process

The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of lipoprotein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.

regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

aminoglycan metabolic process

The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.

regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

negative regulation of protein metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

polysaccharide metabolic process

The chemical reactions and pathways involving polysaccharides, a polymer of more than 20 monosaccharide residues joined by glycosidic linkages.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

activation of immune response

Any process that initiates an immune response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

positive regulation of coagulation

Any process that activates or increases the frequency, rate or extent of coagulation.

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

lipid transport

The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

hormone metabolic process

The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.

amide biosynthetic process

The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.

negative regulation of cellular protein metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

negative regulation of cellular protein metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

negative regulation of lipoprotein metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

negative regulation of protein metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

negative regulation of cellular protein metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

regulation of lipoprotein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.

negative regulation of lipoprotein metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

intestinal cholesterol absorption

Uptake of cholesterol into the blood by absorption from the small intestine.

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

negative regulation of fibrinolysis

Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

regulation of wound healing

Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

negative regulation of lipoprotein oxidation

Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

regulation of fibrinolysis

Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

negative regulation of fibrinolysis

Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

intestinal cholesterol absorption

Uptake of cholesterol into the blood by absorption from the small intestine.

negative regulation of plasma lipoprotein oxidation

Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

regulation of lipoprotein oxidation

Any process that modulates the frequency, rate or extent of lipoprotein oxidation.

negative regulation of lipoprotein oxidation

Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

regulation of plasma lipoprotein oxidation

Any process that modulates the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma.

negative regulation of plasma lipoprotein oxidation

Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

protein-lipid complex

A macromolecular complex containing both protein and lipid molecules.

plasma lipoprotein particle

A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

all

NA

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

plasma lipoprotein particle

A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.

plasma lipoprotein particle

A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

enzyme inhibitor activity

Stops, prevents or reduces the activity of an enzyme.

endopeptidase inhibitor activity

Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

serine-type endopeptidase inhibitor activity

Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

carbohydrate binding

Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

lipid transporter activity

Enables the directed movement of lipids into, out of, within or between cells.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

lipid binding

Interacting selectively and non-covalently with a lipid.

endopeptidase regulator activity

Modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

sterol transporter activity

Enables the directed movement of sterols into, out of, within or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

cholesterol transporter activity

Enables the directed movement of cholesterol into, out of, within or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

vitamin binding

Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

enzyme regulator activity

Modulates the activity of an enzyme.

peptidase regulator activity

Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

all

NA

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

endopeptidase inhibitor activity

Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0045087	4.234e-09	2.643	19 APOA4, C4BPA, C5, C8A, C8B, C9, CD180, CD209, CFP, CRISP3, FCN2, HPX, LBP, MARCO, MASP2, PGLYRP2, TLR1, TNFAIP8L2, VNN1	164	innate immune response
GO:0006952	1.140e-08	8.413	32 AOAH, APOA4, C4BPA, C5, C8A, C8B, C9, CAMP, CCL23, CCL24, CD180, CD209, CD5L, CFP, CRISP3, CXCR2, F2, FCN2, HPX, ITIH4, LBP, MARCO, MASP2, NLRP12, PGLYRP2, PLA2G2D, SIGLEC1, STAB2, TLR1, TNFAIP8L2, TRAT1, VNN1	522	defense response
GO:0009611	5.295e-08	7.961	30 AOAH, C4BPA, C5, C8A, C8B, C9, CCL23, CCL24, CD180, CFP, CPB2, CXCR2, CYP1A1, F2, F2RL2, F9, FCN2, FGB, HRG, ITIH4, LBP, MASP2, NLRP12, PLA2G2D, PROZ, SERPIND1, SIGLEC1, TLR1, TM4SF4, VNN1	494	response to wounding
GO:0002526	6.024e-07	1.257	12 C4BPA, C5, C8A, C8B, C9, CFP, F2, FCN2, ITIH4, LBP, MASP2, VNN1	78	acute inflammatory response
GO:0006956	7.736e-07	0.419	8 C4BPA, C5, C8A, C8B, C9, CFP, FCN2, MASP2	26	complement activation
GO:0002541	1.810e-06	0.4674	8 C4BPA, C5, C8A, C8B, C9, CFP, FCN2, MASP2	29	activation of plasma proteins involved in acute inflammatory response
GO:0006954	2.943e-06	4.964	21 AOAH, C4BPA, C5, C8A, C8B, C9, CCL23, CCL24, CD180, CFP, CXCR2, F2, FCN2, ITIH4, LBP, MASP2, NLRP12, PLA2G2D, SIGLEC1, TLR1, VNN1	308	inflammatory response
GO:0008202	1.417e-05	2.804	15 AFP, AKR1D1, APOA4, APOB, APOF, COMT, CYP17A1, CYP1A1, ESR1, FGF23, NR5A2, NSDHL, SOAT2, SULT2A1, TM7SF2	174	steroid metabolic process
GO:0002455	1.447e-05	0.419	7 C4BPA, C5, C8A, C8B, C9, HPX, MASP2	26	humoral immune response mediated by circulating immunoglobulin
GO:0050896	1.662e-05	40.73	71 ABCG5, AFP, AGXT, ALG2, AOAH, APOA4, APOB, AQP8, C4BPA, C5, C8A, C8B, C9, CAMP, CCL23, CCL24, CD180, CD1C, CD209, CD5L, CFP, CIDEB, CNIH, COMT, CPB2, CRISP3, CXCR2, CYP17A1, CYP1A1, EDEM1, ENDOG, ESR1, F2, F2RL2, F9, FCN2, FGB, FOXA1, FOXP3, GNAT1, GYS2, HPX, HRG, IL1R2, ITIH4, LBP, LECT2, LONP2, MARCO, MASP2, NLRP12, OR10H3, PEMT, PFKFB1, PGLYRP2, PLA2G2D, PON1, PROZ, SERPINA7, SERPIND1, SIGLEC1, SOAT2, STAB2, SYVN1, TAT, TLR1, TM4SF4, TNFAIP8L2, TRAT1, TTPA, VNN1	2527	response to stimulus
GO:0006958	1.883e-05	0.274	6 C4BPA, C5, C8A, C8B, C9, MASP2	17	complement activation, classical pathway
GO:0006957	4.306e-05	0.1773	5 C5, C8A, C8B, C9, CFP	11	complement activation, alternative pathway
GO:0006959	5.479e-05	0.9992	9 C4BPA, C5, C8A, C8B, C9, CFP, FCN2, HPX, MASP2	62	humoral immune response
GO:0002253	5.939e-05	1.305	10 C4BPA, C5, C8A, C8B, C9, CFP, FCN2, LBP, MASP2, TRAT1	81	activation of immune response
GO:0051605	6.182e-05	1.015	9 C4BPA, C5, C8A, C8B, C9, CFP, FCN2, LONP2, MASP2	63	protein maturation by peptide bond cleavage
GO:0006955	7.675e-05	8.397	25 APOA4, C4BPA, C5, C8A, C8B, C9, CCL23, CCL24, CD180, CD1C, CD209, CFP, CNIH, CRISP3, FCN2, FOXP3, HPX, IL1R2, LBP, MARCO, MASP2, PGLYRP2, TLR1, TNFAIP8L2, VNN1	521	immune response
GO:0006950	8.587e-05	23.26	47 AOAH, APOA4, C4BPA, C5, C8A, C8B, C9, CAMP, CCL23, CCL24, CD180, CD209, CD5L, CFP, CIDEB, COMT, CPB2, CRISP3, CXCR2, CYP1A1, EDEM1, F2, F2RL2, F9, FCN2, FGB, HPX, HRG, ITIH4, LBP, MARCO, MASP2, NLRP12, PFKFB1, PGLYRP2, PLA2G2D, PROZ, SERPIND1, SIGLEC1, STAB2, SYVN1, TAT, TLR1, TM4SF4, TNFAIP8L2, TRAT1, VNN1	1443	response to stress
GO:0009308	3.220e-04	5.206	18 AGXT, AMDHD1, APOA4, ARG1, COMT, CYP1A1, HAL, ITIH1, ITIH3, ITIH4, MAT1A, OTC, PEMT, PGLYRP2, PON1, PRHOXNB, TAT, UROC1	323	amine metabolic process
GO:0050778	3.523e-04	1.998	11 C4BPA, C5, C8A, C8B, C9, CFP, FCN2, HPX, LBP, MASP2, TRAT1	124	positive regulation of immune response
GO:0016485	5.316e-04	1.354	9 C4BPA, C5, C8A, C8B, C9, CFP, FCN2, LONP2, MASP2	84	protein processing
GO:0006725	7.458e-04	1.789	10 COMT, CYP1A1, FPGS, MOCOS, PEMT, PON1, PRHOXNB, SLC19A3, TAT, XDH	111	cellular aromatic compound metabolic process
GO:0051604	7.979e-04	1.434	9 C4BPA, C5, C8A, C8B, C9, CFP, FCN2, LONP2, MASP2	89	protein maturation
GO:0002376	9.846e-04	13.2	30 APOA4, C4BPA, C5, C8A, C8B, C9, CCL23, CCL24, CD180, CD1C, CD209, CFP, CNIH, CRISP3, CXCR2, FCN2, FOXP3, FST, HPX, IL1R2, ITIH1, LBP, MARCO, MASP2, ONECUT1, PGLYRP2, TLR1, TNFAIP8L2, TRAT1, VNN1	819	immune system process
GO:0016064	1.227e-03	0.8542	7 C4BPA, C5, C8A, C8B, C9, HPX, MASP2	53	immunoglobulin mediated immune response
GO:0019724	1.367e-03	0.8703	7 C4BPA, C5, C8A, C8B, C9, HPX, MASP2	54	B cell mediated immunity
GO:0034754	1.367e-03	0.8703	7 ADH4, AFP, AKR1D1, COMT, CYP17A1, CYP1A1, ESR1	54	cellular hormone metabolic process
GO:0007596	1.455e-03	1.563	9 C9, CPB2, F2, F2RL2, F9, FGB, HRG, PROZ, SERPIND1	97	blood coagulation
GO:0050817	1.672e-03	1.596	9 C9, CPB2, F2, F2RL2, F9, FGB, HRG, PROZ, SERPIND1	99	coagulation
GO:0007599	2.031e-03	1.644	9 C9, CPB2, F2, F2RL2, F9, FGB, HRG, PROZ, SERPIND1	102	hemostasis
GO:0009605	2.462e-03	8.638	22 ABCG5, C5, CCL23, CCL24, CPB2, CXCR2, CYP1A1, F2, GNAT1, HRG, LBP, LECT2, NLRP12, PEMT, PFKFB1, PGLYRP2, PON1, SERPINA7, SERPIND1, SOAT2, TLR1, TTPA	536	response to external stimulus
GO:0050878	2.845e-03	2.595	11 C9, CPB2, F2, F2RL2, F9, FGB, GUCA2B, HRG, PROZ, SERPIND1, XDH	161	regulation of body fluid levels
GO:0042221	3.031e-03	18.53	36 ABCG5, AFP, AGXT, ALG2, APOA4, APOB, AQP8, C5, CAMP, CCL23, CCL24, COMT, CPB2, CXCR2, CYP17A1, CYP1A1, EDEM1, ENDOG, ESR1, FGB, FOXA1, GYS2, HPX, LBP, LECT2, LONP2, PEMT, PFKFB1, PON1, SERPINA7, SERPIND1, SOAT2, TAT, TLR1, TTPA, VNN1	1150	response to chemical stimulus
GO:0050776	3.073e-03	3.094	12 C4BPA, C5, C8A, C8B, C9, CFP, FCN2, FOXP3, HPX, LBP, MASP2, TRAT1	192	regulation of immune response
GO:0002252	3.438e-03	2.659	11 C4BPA, C5, C8A, C8B, C9, CFP, FCN2, FOXP3, HPX, LBP, MASP2	165	immune effector process
GO:0044282	3.571e-03	5.27	16 ADH4, AKR1D1, AMDHD1, ARG1, CCL24, COMT, FGD2, FGF23, HAL, PFKFB1, PON1, SULT2A1, TAT, TBC1D8B, UROC1, XDH	327	small molecule catabolic process
GO:0002449	3.659e-03	1.402	8 C4BPA, C5, C8A, C8B, C9, FOXP3, HPX, MASP2	87	lymphocyte mediated immunity
GO:0044281	4.184e-03	21.16	39 ACOT12, ADH4, AGXT, AKR1D1, AMDHD1, APOA4, APOB, APOF, ARG1, CCL24, COMT, CYP1A1, FGD2, FGF23, FPGS, GUCA2B, GYS2, HAL, MAT1A, MCFD2, NR5A2, NSDHL, ONECUT1, OTC, PEMT, PFKFB1, PON1, PRHOXNB, SERPINA12, SLC19A3, SOAT2, SULT2A1, TAT, TBC1D8B, TM7SF2, TTPA, UROC1, VNN1, XDH	1313	small molecule metabolic process
GO:0002460	5.435e-03	1.499	8 C4BPA, C5, C8A, C8B, C9, FOXP3, HPX, MASP2	93	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0042445	5.773e-03	1.515	8 ADH4, AFP, AKR1D1, COMT, CYP17A1, CYP1A1, ESR1, FOXA1	94	hormone metabolic process
GO:0006629	5.857e-03	11.28	25 ACOT12, ADH4, AFP, AKR1D1, AOAH, APOA4, APOB, APOF, COMT, CYP17A1, CYP1A1, ESR1, FGF23, LIPM, NR5A2, NSDHL, PEMT, PLA2G2D, PON1, RDH16, SLC35C1, SOAT2, SULT2A1, TM7SF2, TTPA	700	lipid metabolic process
GO:0030212	5.955e-03	0.1128	3 ITIH1, ITIH3, ITIH4	7	hyaluronan metabolic process
GO:0043604	5.955e-03	0.1128	3 ARG1, OTC, PRHOXNB	7	amide biosynthetic process
GO:0051918	5.955e-03	0.1128	3 CPB2, F2, HRG	7	negative regulation of fibrinolysis
GO:0006519	6.046e-03	4.432	14 AGXT, AMDHD1, APOA4, ARG1, COMT, CYP1A1, HAL, MAT1A, OTC, PEMT, PON1, TAT, UROC1, VNN1	275	cellular amino acid and derivative metabolic process
GO:0002250	6.128e-03	1.531	8 C4BPA, C5, C8A, C8B, C9, FOXP3, HPX, MASP2	95	adaptive immune response
GO:0016054	6.500e-03	1.547	8 AKR1D1, AMDHD1, ARG1, HAL, PON1, SULT2A1, TAT, UROC1	96	organic acid catabolic process
GO:0046395	6.500e-03	1.547	8 AKR1D1, AMDHD1, ARG1, HAL, PON1, SULT2A1, TAT, UROC1	96	carboxylic acid catabolic process
GO:0019835	6.983e-03	0.2901	4 C5, C8A, C8B, C9	18	cytolysis
GO:0065008	7.175e-03	21.82	39 ABCG5, ADH4, AFP, AKR1D1, APOA4, APOB, ARPC4, C9, CAMP, CCL23, CCL24, COMT, CP, CPB2, CYP17A1, CYP1A1, DSC3, ESR1, F2, F2RL2, F9, FGB, FGD2, FGF23, FOXA1, FOXP3, FST, GCKR, GDF2, GUCA2B, HPX, HRG, NR5A2, OTC, PROZ, SERPIND1, SOAT2, TFR2, XDH	1354	regulation of biological quality
GO:0042632	7.937e-03	0.548	5 ABCG5, APOA4, APOB, NR5A2, SOAT2	34	cholesterol homeostasis
GO:0055092	7.937e-03	0.548	5 ABCG5, APOA4, APOB, NR5A2, SOAT2	34	sterol homeostasis
GO:0002684	8.045e-03	3.497	12 C4BPA, C5, C8A, C8B, C9, CFP, FCN2, HPX, LBP, MASP2, TRAT1, VNN1	217	positive regulation of immune system process
GO:0008203	8.556e-03	1.225	7 AKR1D1, APOA4, APOB, APOF, NSDHL, SOAT2, TM7SF2	76	cholesterol metabolic process
GO:0030299	8.660e-03	0.1289	3 ABCG5, APOA4, SOAT2	8	intestinal cholesterol absorption
GO:0050746	8.660e-03	0.1289	3 APOA4, PEMT, PON1	8	regulation of lipoprotein metabolic process
GO:0034441	9.918e-03	0.03223	2 APOA4, PON1	2	plasma lipoprotein oxidation
GO:0034444	9.918e-03	0.03223	2 APOA4, PON1	2	regulation of plasma lipoprotein oxidation
GO:0034445	9.918e-03	0.03223	2 APOA4, PON1	2	negative regulation of plasma lipoprotein oxidation
GO:0019752	1.031e-02	7.768	19 ACOT12, AGXT, AKR1D1, AMDHD1, APOA4, ARG1, COMT, CYP1A1, FPGS, HAL, MAT1A, MCFD2, NR5A2, OTC, PFKFB1, PON1, SULT2A1, TAT, UROC1	482	carboxylic acid metabolic process
GO:0043436	1.031e-02	7.768	19 ACOT12, AGXT, AKR1D1, AMDHD1, APOA4, ARG1, COMT, CYP1A1, FPGS, HAL, MAT1A, MCFD2, NR5A2, OTC, PFKFB1, PON1, SULT2A1, TAT, UROC1	482	oxoacid metabolic process
GO:0006082	1.116e-02	7.833	19 ACOT12, AGXT, AKR1D1, AMDHD1, APOA4, ARG1, COMT, CYP1A1, FPGS, HAL, MAT1A, MCFD2, NR5A2, OTC, PFKFB1, PON1, SULT2A1, TAT, UROC1	486	organic acid metabolic process
GO:0002443	1.123e-02	1.708	8 C4BPA, C5, C8A, C8B, C9, FOXP3, HPX, MASP2	106	leukocyte mediated immunity
GO:0006548	1.173e-02	0.145	3 AMDHD1, HAL, UROC1	9	histidine catabolic process
GO:0009077	1.173e-02	0.145	3 AMDHD1, HAL, UROC1	9	histidine family amino acid catabolic process
GO:0044241	1.173e-02	0.145	3 ABCG5, APOA4, SOAT2	9	lipid digestion
GO:0009310	1.180e-02	0.9347	6 AMDHD1, ARG1, COMT, HAL, TAT, UROC1	58	amine catabolic process
GO:0048584	1.184e-02	3.691	12 C4BPA, C5, C8A, C8B, C9, CFP, FCN2, HPX, LBP, MASP2, NLRP12, TRAT1	229	positive regulation of response to stimulus
GO:0016125	1.234e-02	1.322	7 AKR1D1, APOA4, APOB, APOF, NSDHL, SOAT2, TM7SF2	82	sterol metabolic process
GO:0042180	1.259e-02	7.929	19 ACOT12, AGXT, AKR1D1, AMDHD1, APOA4, ARG1, COMT, CYP1A1, FPGS, HAL, MAT1A, MCFD2, NR5A2, OTC, PFKFB1, PON1, SULT2A1, TAT, UROC1	492	cellular ketone metabolic process
GO:0051917	1.547e-02	0.1612	3 CPB2, F2, HRG	10	regulation of fibrinolysis
GO:0042060	1.614e-02	2.788	10 C9, CPB2, F2, F2RL2, F9, FGB, HRG, PROZ, SERPIND1, TM4SF4	173	wound healing
GO:0044106	1.661e-02	3.868	12 AGXT, AMDHD1, APOA4, ARG1, COMT, HAL, MAT1A, OTC, PEMT, PON1, TAT, UROC1	240	cellular amine metabolic process
GO:0033344	1.764e-02	0.3868	4 ABCG5, APOA4, PON1, SOAT2	24	cholesterol efflux
GO:0015918	1.926e-02	0.693	5 ABCG5, APOA4, APOB, PON1, SOAT2	43	sterol transport
GO:0030301	1.926e-02	0.693	5 ABCG5, APOA4, APOB, PON1, SOAT2	43	cholesterol transport
GO:0006547	1.967e-02	0.1773	3 AMDHD1, HAL, UROC1	11	histidine metabolic process
GO:0009075	1.967e-02	0.1773	3 AMDHD1, HAL, UROC1	11	histidine family amino acid metabolic process
GO:0030194	1.967e-02	0.1773	3 CPB2, F2, HRG	11	positive regulation of blood coagulation
GO:0034377	1.967e-02	0.1773	3 APOA4, APOB, SOAT2	11	plasma lipoprotein particle assembly
GO:0065005	1.967e-02	0.1773	3 APOA4, APOB, SOAT2	11	protein-lipid complex assembly
GO:0055088	2.086e-02	0.7091	5 ABCG5, APOA4, APOB, NR5A2, SOAT2	44	lipid homeostasis
GO:0010817	2.247e-02	2.949	10 ADH4, AFP, AKR1D1, COMT, CYP17A1, CYP1A1, ESR1, FGF23, FOXA1, FST	183	regulation of hormone levels
GO:0030300	2.301e-02	0.04835	2 ABCG5, APOA4	3	regulation of intestinal cholesterol absorption
GO:0030573	2.301e-02	0.04835	2 AKR1D1, SULT2A1	3	bile acid catabolic process
GO:0034442	2.301e-02	0.04835	2 APOA4, PON1	3	regulation of lipoprotein oxidation
GO:0034443	2.301e-02	0.04835	2 APOA4, PON1	3	negative regulation of lipoprotein oxidation
GO:0042160	2.301e-02	0.04835	2 APOA4, PON1	3	lipoprotein modification
GO:0042161	2.301e-02	0.04835	2 APOA4, PON1	3	lipoprotein oxidation
GO:0050892	2.401e-02	0.1934	3 ABCG5, APOA4, SOAT2	12	intestinal absorption
GO:0042730	2.846e-02	0.2095	3 CPB2, F2, HRG	13	fibrinolysis
GO:0043603	2.846e-02	0.2095	3 ARG1, OTC, PRHOXNB	13	cellular amide metabolic process
GO:0050820	2.846e-02	0.2095	3 CPB2, F2, HRG	13	positive regulation of coagulation
GO:0006066	2.870e-02	6.044	15 ADH4, AKR1D1, APOA4, APOB, APOF, COMT, GYS2, NSDHL, ONECUT1, PEMT, PFKFB1, PON1, SERPINA12, SOAT2, TM7SF2	375	alcohol metabolic process
GO:0008228	3.737e-02	0.06447	2 FCN2, LBP	4	opsonization
GO:0009063	3.828e-02	0.8542	5 AMDHD1, ARG1, HAL, TAT, UROC1	53	cellular amino acid catabolic process
GO:0046470	3.909e-02	0.2417	3 APOA4, PEMT, PON1	15	phosphatidylcholine metabolic process
GO:0006775	4.318e-02	0.5318	4 ADH4, CYP1A1, FGF23, TTPA	33	fat-soluble vitamin metabolic process
GO:0048583	4.407e-02	7.075	16 C4BPA, C5, C8A, C8B, C9, CFP, CPB2, F2, FCN2, FOXP3, HPX, HRG, LBP, MASP2, NLRP12, TRAT1	439	regulation of response to stimulus

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005576	4.104e-15	22.64	67 ADAM12, AFP, AOAH, APOA4, APOB, APOF, BPIL1, C20orf70, C4BPA, C5, C8A, C8B, C9, CAMP, CCDC134, CCL23, CCL24, CD209, CD5L, CFP, CP, CPA6, CPB2, CRISP3, DKK2, DNASE2B, F2, F9, FCN2, FETUB, FGB, FGF23, FST, GC, GDF2, GUCA2B, HPX, HRG, IGFALS, INHBE, ITIH1, ITIH3, ITIH4, LBP, LECT2, LIPM, MASP2, MCFD2, MSMB, PAEP, PGLYRP2, PLA2G2D, PON1, PROZ, PRSS53, PRSSL1, SERPINA11, SERPINA12, SERPINA4, SERPINA7, SERPIND1, SIGLEC1, SPP2, TECTB, VMO1, VWCE, XDH	1407	extracellular region
GO:0005615	6.065e-07	8.834	29 AFP, APOA4, APOB, APOF, C5, C8A, C8B, CAMP, CCL23, CCL24, CD5L, CFP, CP, CPB2, DKK2, F2, FCN2, FGB, FGF23, GC, GDF2, HPX, IGFALS, LBP, LECT2, MSMB, PON1, SERPINA4, SERPINA7	549	extracellular space
GO:0044421	2.415e-05	11.89	31 AFP, APOA4, APOB, APOF, C5, C8A, C8B, CAMP, CCL23, CCL24, CD5L, CFP, CP, CPB2, CRISP3, DKK2, F2, FCN2, FGB, FGF23, GC, GDF2, HPX, IGFALS, LBP, LECT2, MSMB, PON1, SERPINA4, SERPINA7, TECTB	739	extracellular region part
GO:0005579	6.296e-05	0.1126	4 C5, C8A, C8B, C9	7	membrane attack complex
GO:0032994	4.992e-03	0.3379	4 APOA4, APOB, APOF, PON1	21	protein-lipid complex
GO:0034358	4.992e-03	0.3379	4 APOA4, APOB, APOF, PON1	21	plasma lipoprotein particle
GO:0034364	1.377e-02	0.2092	3 APOA4, APOF, PON1	13	high-density lipoprotein particle
GO:0005792	4.833e-02	2.623	8 APOB, AQP8, COMT, CYP1A1, CYP3A43, PON1, RDH16, SOAT2	163	microsome

Id	Pvalue	ExpCount	Count	Size	Term
GO:0004866	5.177e-06	1.591	12 C5, FETUB, HRG, ITIH1, ITIH3, ITIH4, SERPINA11, SERPINA12, SERPINA4, SERPINA7, SERPIND1, SPP2	103	endopeptidase inhibitor activity
GO:0061135	6.947e-06	1.637	12 C5, FETUB, HRG, ITIH1, ITIH3, ITIH4, SERPINA11, SERPINA12, SERPINA4, SERPINA7, SERPIND1, SPP2	106	endopeptidase regulator activity
GO:0030414	8.378e-06	1.668	12 C5, FETUB, HRG, ITIH1, ITIH3, ITIH4, SERPINA11, SERPINA12, SERPINA4, SERPINA7, SERPIND1, SPP2	108	peptidase inhibitor activity
GO:0061134	9.229e-06	2.023	13 C5, FETUB, HRG, ITIH1, ITIH3, ITIH4, NLRP12, SERPINA11, SERPINA12, SERPINA4, SERPINA7, SERPIND1, SPP2	131	peptidase regulator activity
GO:0004867	8.833e-05	1.096	9 HRG, ITIH1, ITIH3, ITIH4, SERPINA11, SERPINA12, SERPINA4, SERPINA7, SERPIND1	71	serine-type endopeptidase inhibitor activity
GO:0008289	1.414e-04	4.957	18 ADH4, AKR1D1, APOA4, APOB, APOF, BPIL1, C20orf70, ESR1, GC, LBP, NR5A2, OTC, PEMT, PON1, SEC14L4, SNX20, SOAT2, VNN1	321	lipid binding
GO:0004857	3.629e-04	2.903	13 C5, FETUB, GCKR, HRG, ITIH1, ITIH3, ITIH4, SERPINA11, SERPINA12, SERPINA4, SERPINA7, SERPIND1, SPP2	188	enzyme inhibitor activity
GO:0019842	1.707e-03	1.652	9 ADH4, AGXT, GC, MOCOS, OAT, SLC19A3, SLC46A1, TAT, TTPA	107	vitamin binding
GO:0017127	8.707e-03	0.139	3 ABCG5, APOA4, APOB	9	cholesterol transporter activity
GO:0030246	9.391e-03	4.216	13 AIM1L, APOB, CCL23, CD209, CD33, FCN2, HRG, LGALS4, PFKFB1, PGLYRP2, SERPIND1, SIGLEC1, STAB2	273	carbohydrate binding
GO:0030234	1.238e-02	10.07	22 APOA4, ARL2BP, C5, CDC42BPA, ESR1, FETUB, FGD2, GCKR, GUCA2B, HRG, ITIH1, ITIH3, ITIH4, NLRP12, RGS18, SERPINA11, SERPINA12, SERPINA4, SERPINA7, SERPIND1, SPP2, TBC1D8B	652	enzyme regulator activity
GO:0015248	1.478e-02	0.1699	3 ABCG5, APOA4, APOB	11	sterol transporter activity
GO:0016597	1.752e-02	0.7103	5 AGXT, OTC, SLC19A3, SLC46A1, TAT	46	amino acid binding
GO:0015232	1.797e-02	0.04633	2 HPX, SLC46A1	3	heme transporter activity
GO:0051636	1.797e-02	0.04633	2 LBP, STAB2	3	Gram-negative bacterial cell surface binding
GO:0005496	2.043e-02	0.7412	5 AKR1D1, APOF, ESR1, GC, SOAT2	48	steroid binding
GO:0004252	2.665e-02	1.621	7 F2, F9, LONP2, MASP2, PROZ, PRSS53, PRSSL1	105	serine-type endopeptidase activity
GO:0043498	3.009e-02	0.4942	4 APOA4, FGB, LBP, STAB2	32	cell surface binding
GO:0008483	4.087e-02	0.2625	3 AGXT, OAT, TAT	17	transaminase activity
GO:0030151	4.388e-02	0.07721	2 MOCOS, XDH	5	molybdenum ion binding
GO:0043176	4.484e-02	1.359	6 AGXT, APOA4, OTC, SLC19A3, SLC46A1, TAT	88	amine binding
GO:0008236	4.741e-02	1.853	7 F2, F9, LONP2, MASP2, PROZ, PRSS53, PRSSL1	120	serine-type peptidase activity

Id	Pvalue	ExpCount	Count	Size	Term
04610	2.118e-07	1.017	11 C4BPA, C5, C8A, C8B, C9, CPB2, F2, F9, FGB, MASP2, SERPIND1	50	Complement and coagulation cascades
00140	2.007e-03	0.4473	5 AKR1D1, COMT, CYP17A1, CYP1A1, CYP3A43	22	Steroid hormone biosynthesis
05020	2.446e-02	0.488	4 C5, C8A, C8B, C9	24	Prion diseases
00830	2.767e-02	0.5083	4 ADH4, CYP1A1, CYP3A43, RDH16	25	Retinol metabolism
00100	2.925e-02	0.244	3 NSDHL, SOAT2, TM7SF2	12	Steroid biosynthesis
00980	3.076e-02	0.5287	4 ADH4, CYP1A1, CYP3A43, GSTA4	26	Metabolism of xenobiotics by cytochrome P450

No enriched terms

No enriched terms

Entrez genes

A4GNTalpha-1,4-N-acetylglucosaminyltransferase (ENSG00000118017), score: 0.85 ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ENSG00000073734), score: 0.67 ABCG5ATP-binding cassette, sub-family G (WHITE), member 5 (ENSG00000138075), score: 0.67 ACOT12acyl-CoA thioesterase 12 (ENSG00000172497), score: 0.66 ADAM12ADAM metallopeptidase domain 12 (ENSG00000148848), score: 0.83 ADH4alcohol dehydrogenase 4 (class II), pi polypeptide (ENSG00000198099), score: 0.67 AFPalpha-fetoprotein (ENSG00000081051), score: 0.66 AGXTalanine-glyoxylate aminotransferase (ENSG00000172482), score: 0.67 AIM1Labsent in melanoma 1-like (ENSG00000176092), score: 0.65 AKR1CL1aldo-keto reductase family 1, member C-like 1 (ENSG00000196326), score: 0.88 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.75 ALG2asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) (ENSG00000119523), score: 0.76 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.69 AOAHacyloxyacyl hydrolase (neutrophil) (ENSG00000136250), score: 0.73 APOA4apolipoprotein A-IV (ENSG00000110244), score: 0.81 APOBapolipoprotein B (including Ag(x) antigen) (ENSG00000084674), score: 0.66 APOFapolipoprotein F (ENSG00000175336), score: 0.84 AQP8aquaporin 8 (ENSG00000103375), score: 0.98 ARG1arginase, liver (ENSG00000118520), score: 0.68 ARL2BPADP-ribosylation factor-like 2 binding protein (ENSG00000102931), score: -0.8 ARPC4actin related protein 2/3 complex, subunit 4, 20kDa (ENSG00000214021), score: -0.67 B3GNT7UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (ENSG00000156966), score: 0.68 BPIL1bactericidal/permeability-increasing protein-like 1 (ENSG00000078898), score: 0.92 C17orf87chromosome 17 open reading frame 87 (ENSG00000161929), score: 0.93 C20orf194chromosome 20 open reading frame 194 (ENSG00000088854), score: -0.67 C20orf70chromosome 20 open reading frame 70 (ENSG00000131050), score: 0.68 C2CD4AC2 calcium-dependent domain containing 4A (ENSG00000198535), score: 0.71 C4BPAcomplement component 4 binding protein, alpha (ENSG00000123838), score: 0.69 C5complement component 5 (ENSG00000106804), score: 0.69 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.73 C8Bcomplement component 8, beta polypeptide (ENSG00000021852), score: 0.72 C9complement component 9 (ENSG00000113600), score: 0.74 C9orf152chromosome 9 open reading frame 152 (ENSG00000188959), score: 0.83 CAMPcathelicidin antimicrobial peptide (ENSG00000164047), score: 0.81 CCDC134coiled-coil domain containing 134 (ENSG00000100147), score: 0.67 CCL23chemokine (C-C motif) ligand 23 (ENSG00000167236), score: 0.76 CCL24chemokine (C-C motif) ligand 24 (ENSG00000106178), score: 0.84 CD180CD180 molecule (ENSG00000134061), score: 0.67 CD1CCD1c molecule (ENSG00000158481), score: 0.71 CD209CD209 molecule (ENSG00000090659), score: 0.91 CD300LFCD300 molecule-like family member f (ENSG00000186074), score: 0.66 CD33CD33 molecule (ENSG00000105383), score: 0.85 CD5LCD5 molecule-like (ENSG00000073754), score: 0.77 CDC42BPACDC42 binding protein kinase alpha (DMPK-like) (ENSG00000143776), score: -0.82 CDK14cyclin-dependent kinase 14 (ENSG00000058091), score: -0.66 CFPcomplement factor properdin (ENSG00000126759), score: 0.76 CIDEBcell death-inducing DFFA-like effector b (ENSG00000136305), score: 0.67 CLDN14claudin 14 (ENSG00000159261), score: 0.77 CNIHcornichon homolog (Drosophila) (ENSG00000100528), score: 0.67 COMTcatechol-O-methyltransferase (ENSG00000093010), score: 0.7 CPceruloplasmin (ferroxidase) (ENSG00000047457), score: 0.7 CPA6carboxypeptidase A6 (ENSG00000165078), score: 0.71 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.65 CRISP3cysteine-rich secretory protein 3 (ENSG00000096006), score: 0.85 CRYBA2crystallin, beta A2 (ENSG00000163499), score: 0.69 CXCR2chemokine (C-X-C motif) receptor 2 (ENSG00000180871), score: 0.96 CYP17A1cytochrome P450, family 17, subfamily A, polypeptide 1 (ENSG00000148795), score: 0.67 CYP1A1cytochrome P450, family 1, subfamily A, polypeptide 1 (ENSG00000140465), score: 0.74 CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 43 (ENSG00000021461), score: 0.72 DKK2dickkopf homolog 2 (Xenopus laevis) (ENSG00000155011), score: 0.68 DNASE2Bdeoxyribonuclease II beta (ENSG00000137976), score: 0.74 DSC3desmocollin 3 (ENSG00000134762), score: 0.81 EDEM1ER degradation enhancer, mannosidase alpha-like 1 (ENSG00000134109), score: 0.66 EMR1egf-like module containing, mucin-like, hormone receptor-like 1 (ENSG00000174837), score: 0.83 ENDOGendonuclease G (ENSG00000167136), score: 0.71 ESR1estrogen receptor 1 (ENSG00000091831), score: 0.65 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.68 F2RL2coagulation factor II (thrombin) receptor-like 2 (ENSG00000164220), score: 0.68 F9coagulation factor IX (ENSG00000101981), score: 0.66 FAM189Bfamily with sequence similarity 189, member B (ENSG00000160767), score: -0.69 FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) (ENSG00000160339), score: 0.66 FETUBfetuin B (ENSG00000090512), score: 0.82 FGBfibrinogen beta chain (ENSG00000171564), score: 0.66 FGD2FYVE, RhoGEF and PH domain containing 2 (ENSG00000146192), score: 0.82 FGF23fibroblast growth factor 23 (ENSG00000118972), score: 0.67 FOXA1forkhead box A1 (ENSG00000129514), score: 0.77 FOXP3forkhead box P3 (ENSG00000049768), score: 1 FPGSfolylpolyglutamate synthase (ENSG00000136877), score: 0.68 FSTfollistatin (ENSG00000134363), score: 0.75 GCgroup-specific component (vitamin D binding protein) (ENSG00000145321), score: 0.69 GCKRglucokinase (hexokinase 4) regulator (ENSG00000084734), score: 0.66 GDF2growth differentiation factor 2 (ENSG00000128802), score: 0.71 GLYATL3glycine-N-acyltransferase-like 3 (ENSG00000203972), score: 0.79 GNAT1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 (ENSG00000114349), score: 0.67 GPRC5DG protein-coupled receptor, family C, group 5, member D (ENSG00000111291), score: 0.76 GSTA4glutathione S-transferase alpha 4 (ENSG00000170899), score: -0.68 GUCA2Bguanylate cyclase activator 2B (uroguanylin) (ENSG00000044012), score: 0.68 GYS2glycogen synthase 2 (liver) (ENSG00000111713), score: 0.65 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.7 HPXhemopexin (ENSG00000110169), score: 0.7 HRASLS2HRAS-like suppressor 2 (ENSG00000133328), score: 0.69 HRGhistidine-rich glycoprotein (ENSG00000113905), score: 0.65 HS3ST3B1heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 (ENSG00000125430), score: 0.67 IGFALSinsulin-like growth factor binding protein, acid labile subunit (ENSG00000099769), score: 0.71 IL1R2interleukin 1 receptor, type II (ENSG00000115590), score: 0.82 INHBEinhibin, beta E (ENSG00000139269), score: 0.66 ITIH1inter-alpha (globulin) inhibitor H1 (ENSG00000055957), score: 0.67 ITIH3inter-alpha (globulin) inhibitor H3 (ENSG00000162267), score: 0.7 ITIH4inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) (ENSG00000055955), score: 0.68 KCNK17potassium channel, subfamily K, member 17 (ENSG00000124780), score: 0.7 KRT27keratin 27 (ENSG00000171446), score: 0.79 KRT28keratin 28 (ENSG00000173908), score: 0.94 LBPlipopolysaccharide binding protein (ENSG00000129988), score: 0.72 LECT2leukocyte cell-derived chemotaxin 2 (ENSG00000145826), score: 0.7 LGALS4lectin, galactoside-binding, soluble, 4 (ENSG00000171747), score: 0.65 LIPMlipase, family member M (ENSG00000173239), score: 0.71 LMBR1limb region 1 homolog (mouse) (ENSG00000105983), score: -0.7 LOC100292202similar to solute carrier family 25, member 25 (ENSG00000148339), score: 0.67 LONP2lon peptidase 2, peroxisomal (ENSG00000102910), score: 0.72 LRRC25leucine rich repeat containing 25 (ENSG00000175489), score: 0.72 LRRC8Eleucine rich repeat containing 8 family, member E (ENSG00000171017), score: 0.72 LYPD3LY6/PLAUR domain containing 3 (ENSG00000124466), score: 0.67 MARCOmacrophage receptor with collagenous structure (ENSG00000019169), score: 0.7 MASP2mannan-binding lectin serine peptidase 2 (ENSG00000009724), score: 0.73 MAT1Amethionine adenosyltransferase I, alpha (ENSG00000151224), score: 0.67 MCFD2multiple coagulation factor deficiency 2 (ENSG00000180398), score: 0.68 MLANAmelan-A (ENSG00000120215), score: 0.77 MOCOSmolybdenum cofactor sulfurase (ENSG00000075643), score: 0.72 MSMBmicroseminoprotein, beta- (ENSG00000138294), score: 0.66 NLRP12NLR family, pyrin domain containing 12 (ENSG00000142405), score: 0.74 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.67 NSDHLNAD(P) dependent steroid dehydrogenase-like (ENSG00000147383), score: 0.68 OATornithine aminotransferase (ENSG00000065154), score: 0.68 OIT3oncoprotein induced transcript 3 (ENSG00000138315), score: 0.66 ONECUT1one cut homeobox 1 (ENSG00000169856), score: 0.81 OR10H3olfactory receptor, family 10, subfamily H, member 3 (ENSG00000171936), score: 0.68 OTCornithine carbamoyltransferase (ENSG00000036473), score: 0.79 PAEPprogestagen-associated endometrial protein (ENSG00000122133), score: 0.67 PEMTphosphatidylethanolamine N-methyltransferase (ENSG00000133027), score: 0.72 PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (ENSG00000158571), score: 0.76 PGLYRP2peptidoglycan recognition protein 2 (ENSG00000161031), score: 0.65 PLA2G2Dphospholipase A2, group IID (ENSG00000117215), score: 0.76 PON1paraoxonase 1 (ENSG00000005421), score: 0.68 PPAPDC1Bphosphatidic acid phosphatase type 2 domain containing 1B (ENSG00000147535), score: 0.86 PRHOXNBparahox cluster neighbor (ENSG00000183463), score: 0.93 PROZprotein Z, vitamin K-dependent plasma glycoprotein (ENSG00000126231), score: 0.71 PRSS53protease, serine, 53 (ENSG00000151006), score: 0.66 PRSSL1protease, serine-like 1 (ENSG00000185198), score: 0.81 PSKH2protein serine kinase H2 (ENSG00000147613), score: 0.77 PTCRApre T-cell antigen receptor alpha (ENSG00000171611), score: 0.88 RDH16retinol dehydrogenase 16 (all-trans) (ENSG00000139547), score: 0.72 RGS13regulator of G-protein signaling 13 (ENSG00000127074), score: 0.82 RGS18regulator of G-protein signaling 18 (ENSG00000150681), score: 0.79 SEC14L4SEC14-like 4 (S. cerevisiae) (ENSG00000133488), score: 0.7 SEC22CSEC22 vesicle trafficking protein homolog C (S. cerevisiae) (ENSG00000093183), score: -0.72 SERPINA11serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 (ENSG00000186910), score: 0.71 SERPINA12serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 (ENSG00000165953), score: 0.78 SERPINA4serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 (ENSG00000100665), score: 0.65 SERPINA7serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 (ENSG00000123561), score: 0.74 SERPIND1serpin peptidase inhibitor, clade D (heparin cofactor), member 1 (ENSG00000099937), score: 0.66 SIDT2SID1 transmembrane family, member 2 (ENSG00000149577), score: 0.68 SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin (ENSG00000088827), score: 0.73 SIRPB2signal-regulatory protein beta 2 (ENSG00000196209), score: 0.66 SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (ENSG00000100652), score: 0.73 SLC17A2solute carrier family 17 (sodium phosphate), member 2 (ENSG00000112337), score: 0.68 SLC19A3solute carrier family 19, member 3 (ENSG00000135917), score: 0.69 SLC22A1solute carrier family 22 (organic cation transporter), member 1 (ENSG00000175003), score: 0.68 SLC30A10solute carrier family 30, member 10 (ENSG00000196660), score: 0.65 SLC35C1solute carrier family 35, member C1 (ENSG00000181830), score: 0.66 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.66 SLC41A2solute carrier family 41, member 2 (ENSG00000136052), score: 0.69 SLC45A3solute carrier family 45, member 3 (ENSG00000158715), score: 0.67 SLC46A1solute carrier family 46 (folate transporter), member 1 (ENSG00000076351), score: 0.67 SLCO1B1solute carrier organic anion transporter family, member 1B1 (ENSG00000134538), score: 0.73 SNX20sorting nexin 20 (ENSG00000167208), score: 0.78 SOAT2sterol O-acyltransferase 2 (ENSG00000167780), score: 0.94 SPIRE1spire homolog 1 (Drosophila) (ENSG00000134278), score: -0.69 SPP2secreted phosphoprotein 2, 24kDa (ENSG00000072080), score: 0.74 SRPRsignal recognition particle receptor (docking protein) (ENSG00000182934), score: 0.71 STAB2stabilin 2 (ENSG00000136011), score: 0.74 SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (ENSG00000105398), score: 0.71 SYVN1synovial apoptosis inhibitor 1, synoviolin (ENSG00000162298), score: 0.73 TATtyrosine aminotransferase (ENSG00000198650), score: 0.73 TBC1D8BTBC1 domain family, member 8B (with GRAM domain) (ENSG00000133138), score: 0.7 TECTBtectorin beta (ENSG00000119913), score: 0.85 TFR2transferrin receptor 2 (ENSG00000106327), score: 0.66 TLE6transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila) (ENSG00000104953), score: 0.71 TLR1toll-like receptor 1 (ENSG00000174125), score: 0.66 TM4SF4transmembrane 4 L six family member 4 (ENSG00000169903), score: 0.68 TM7SF2transmembrane 7 superfamily member 2 (ENSG00000149809), score: 0.72 TMEM154transmembrane protein 154 (ENSG00000170006), score: 0.78 TNFAIP8L2tumor necrosis factor, alpha-induced protein 8-like 2 (ENSG00000163154), score: 0.74 TOB1transducer of ERBB2, 1 (ENSG00000141232), score: 0.68 TRAT1T cell receptor associated transmembrane adaptor 1 (ENSG00000163519), score: 0.83 TRPM5transient receptor potential cation channel, subfamily M, member 5 (ENSG00000070985), score: 0.82 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.74 TTPALtocopherol (alpha) transfer protein-like (ENSG00000124120), score: 0.72 UROC1urocanase domain containing 1 (ENSG00000159650), score: 0.71 VMO1vitelline membrane outer layer 1 homolog (chicken) (ENSG00000182853), score: 0.79 VNN1vanin 1 (ENSG00000112299), score: 0.65 VWCEvon Willebrand factor C and EGF domains (ENSG00000167992), score: 0.77 XDHxanthine dehydrogenase (ENSG00000158125), score: 0.74

Non-Entrez genes

ENSG00000147383Unknown, score: 0.98 ENSG00000044012Unknown, score: 0.76 ENSG00000119523Unknown, score: 0.77

Id	species	tissue	sex	individual
ppy_lv_f_ca1	ppy	lv	f	_
ppy_lv_m_ca1	ppy	lv	m	_
mml_lv_f_ca1	mml	lv	f	_
mml_lv_m_ca1	mml	lv	m	_