Under-expression is coded with green,
over-expression with red color.
system process
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
cell communication
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
cell surface receptor linked signaling pathway
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
G-protein coupled receptor protein signaling pathway
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
gamma-aminobutyric acid signaling pathway
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
cell-cell signaling
Any process that mediates the transfer of information from one cell to another.
synaptic transmission
The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
neurological system process
A organ system process carried out by any of the organs or tissues of neurological system.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
transmission of nerve impulse
The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.
signaling pathway
The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.
signaling process
Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.
signaling
The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.
signal transmission
The process whereby a signal is released and/or conveyed from one location to another.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
all
NA
signaling process
Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.
cell-cell signaling
Any process that mediates the transfer of information from one cell to another.
transmission of nerve impulse
The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.
synaptic transmission
The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
transmission of nerve impulse
The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
cell junction
A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
intrinsic to membrane
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
ion channel complex
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
chloride channel complex
An ion channel complex through which chloride ions pass.
protein complex
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
synapse part
Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
synapse
The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
postsynaptic membrane
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.
all
NA
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
synapse part
Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
postsynaptic membrane
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.
ion channel complex
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
ion channel complex
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
signal transducer activity
Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.
receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
transmembrane receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
GABA-A receptor activity
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
transporter activity
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
ion channel activity
Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
extracellular ligand-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts.
anion channel activity
Catalysis of the energy-independent passage of anions across a lipid bilayer down a concentration gradient.
chloride channel activity
Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
transmembrane transporter activity
Enables the transfer of a substance from one side of a membrane to the other.
anion transmembrane transporter activity
Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other.
ion transmembrane transporter activity
Catalysis of the transfer of an ion from one side of a membrane to the other.
channel activity
Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
ligand-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
GABA receptor activity
Combining with gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to initiate a change in cell activity.
passive transmembrane transporter activity
Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.
ligand-gated channel activity
Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
gated channel activity
Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.
substrate-specific channel activity
Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
substrate-specific transporter activity
Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
molecular transducer activity
The molecular function that accepts an input of one form and creates an output of a different form.
all
NA
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
substrate-specific channel activity
Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
ion channel activity
Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
anion channel activity
Catalysis of the energy-independent passage of anions across a lipid bilayer down a concentration gradient.
ligand-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
Id | Pvalue | ExpCount | Count | Size | Term |
---|---|---|---|---|---|
04080 | 1.814e-04 | 0.4922 | 6 | 102 | Neuroactive ligand-receptor interaction |
BEGAINbrain-enriched guanylate kinase-associated homolog (rat) (ENSG00000183092), score: 0.94 C12orf53chromosome 12 open reading frame 53 (ENSG00000139200), score: 0.95 C6orf168chromosome 6 open reading frame 168 (ENSG00000146267), score: 0.94 CDH10cadherin 10, type 2 (T2-cadherin) (ENSG00000040731), score: 0.92 CNTN6contactin 6 (ENSG00000134115), score: 0.92 FBXL16F-box and leucine-rich repeat protein 16 (ENSG00000127585), score: 0.95 GABRA1gamma-aminobutyric acid (GABA) A receptor, alpha 1 (ENSG00000022355), score: 0.93 GABRB3gamma-aminobutyric acid (GABA) A receptor, beta 3 (ENSG00000166206), score: 0.95 GABRG1gamma-aminobutyric acid (GABA) A receptor, gamma 1 (ENSG00000163285), score: 1 GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 2 (ENSG00000113327), score: 0.94 GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 1 (ENSG00000176884), score: 0.95 HRH3histamine receptor H3 (ENSG00000101180), score: 0.99 KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 2 (ENSG00000075043), score: 1 KCNT1potassium channel, subfamily T, member 1 (ENSG00000107147), score: 0.97 MTFR1mitochondrial fission regulator 1 (ENSG00000066855), score: -0.87 MYT1Lmyelin transcription factor 1-like (ENSG00000186487), score: 0.96 PHACTR3phosphatase and actin regulator 3 (ENSG00000087495), score: 0.93 RGS20regulator of G-protein signaling 20 (ENSG00000147509), score: 0.94 RIMS3regulating synaptic membrane exocytosis 3 (ENSG00000117016), score: 0.96 RIT2Ras-like without CAAX 2 (ENSG00000152214), score: 0.94 SCRG1stimulator of chondrogenesis 1 (ENSG00000164106), score: 0.92 STMN4stathmin-like 4 (ENSG00000015592), score: 0.94 SULT4A1sulfotransferase family 4A, member 1 (ENSG00000130540), score: 0.93 SV2Bsynaptic vesicle glycoprotein 2B (ENSG00000185518), score: 0.92 TMEM59Ltransmembrane protein 59-like (ENSG00000105696), score: 0.95 UNC5Aunc-5 homolog A (C. elegans) (ENSG00000113763), score: 0.95 ZDHHC22zinc finger, DHHC-type containing 22 (ENSG00000177108), score: 0.96 ZNF365zinc finger protein 365 (ENSG00000138311), score: 0.92
Id | species | tissue | sex | individual |
---|---|---|---|---|
ptr_cb_f_ca1 | ptr | cb | f | _ |
mmu_cb_m2_ca1 | mmu | cb | m | 2 |
gga_br_m_ca1 | gga | br | m | _ |
ggo_cb_m_ca1 | ggo | cb | m | _ |
ppy_cb_f_ca1 | ppy | cb | f | _ |
gga_br_f_ca1 | gga | br | f | _ |
ptr_cb_m_ca1 | ptr | cb | m | _ |
mml_cb_f_ca1 | mml | cb | f | _ |
ppa_cb_f_ca1 | ppa | cb | f | _ |
mmu_cb_f_ca1 | mmu | cb | f | _ |
ppa_cb_m_ca1 | ppa | cb | m | _ |
mmu_cb_m1_ca1 | mmu | cb | m | 1 |
mml_cb_m_ca1 | mml | cb | m | _ |
ggo_cb_f_ca1 | ggo | cb | f | _ |
hsa_cb_f_ca1 | hsa | cb | f | _ |
ppa_br_f2_ca1 | ppa | br | f | 2 |
hsa_cb_m_ca1 | hsa | cb | m | _ |
ptr_br_f_ca1 | ptr | br | f | _ |
mmu_br_m2_ca1 | mmu | br | m | 2 |
mmu_br_f_ca1 | mmu | br | f | _ |
ppa_br_m_ca1 | ppa | br | m | _ |
mmu_br_m1_ca1 | mmu | br | m | 1 |
mml_br_m1_ca1 | mml | br | m | 1 |
hsa_br_m1_ca1 | hsa | br | m | 1 |
hsa_br_f_ca1 | hsa | br | f | _ |
ptr_br_m2_ca1 | ptr | br | m | 2 |
ptr_br_m4_ca1 | ptr | br | m | 4 |
ptr_br_m3_ca1 | ptr | br | m | 3 |
ptr_br_m5_ca1 | ptr | br | m | 5 |
mml_br_f_ca1 | mml | br | f | _ |
hsa_br_m2_ca1 | hsa | br | m | 2 |
ggo_br_m_ca1 | ggo | br | m | _ |
ppy_br_f_ca1 | ppy | br | f | _ |
ggo_br_f_ca1 | ggo | br | f | _ |
ppa_br_f1_ca1 | ppa | br | f | 1 |
hsa_br_m3_ca1 | hsa | br | m | 3 |
mml_br_m2_ca1 | mml | br | m | 2 |
ppy_br_m_ca1 | ppy | br | m | _ |
ptr_br_m1_ca1 | ptr | br | m | 1 |
hsa_br_m7_ca1 | hsa | br | m | 7 |