Under-expression is coded with green,
over-expression with red color.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
adaptive immune response
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).
immune effector process
Any process of the immune system that occurs as part of an immune response.
activation of immune response
Any process that initiates an immune response.
immune system process
Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
leukocyte mediated immunity
Any process involved in the carrying out of an immune response by a leukocyte.
lymphocyte mediated immunity
Any process involved in the carrying out of an immune response by a lymphocyte.
humoral immune response mediated by circulating immunoglobulin
An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.
acute inflammatory response
Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
activation of plasma proteins involved in acute inflammatory response
Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
regulation of immune system process
Any process that modulates the frequency, rate, or extent of an immune system process.
positive regulation of immune system process
Any process that activates or increases the frequency, rate, or extent of an immune system process.
response to unfolded protein
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
defense response
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
blood coagulation
The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
alcohol metabolic process
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
organic acid metabolic process
The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
oxidation reduction
The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons.
protein maturation by peptide bond cleavage
The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
cellular amino acid derivative metabolic process
The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
lipid metabolic process
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
fatty acid metabolic process
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
steroid biosynthetic process
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
cellular aromatic compound metabolic process
The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
coenzyme metabolic process
The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
response to stress
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
inflammatory response
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
immune response
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
complement activation, alternative pathway
Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
complement activation, classical pathway
Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
humoral immune response
An immune response mediated through a body fluid.
hemostasis
The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
steroid metabolic process
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
cholesterol metabolic process
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
cell death
A biological process that results in permanent cessation of all vital functions of a cell.
cytolysis
The rupture of cell membranes and the loss of cytoplasm.
negative regulation of coagulation
Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.
lipid biosynthetic process
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
biosynthetic process
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
cellular amino acid catabolic process
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
serine family amino acid metabolic process
The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.
aromatic amino acid family metabolic process
The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
aromatic amino acid family catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
amine catabolic process
The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
response to external stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
response to biotic stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
response to wounding
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
response to organic substance
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
gene expression
The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
organic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
immunoglobulin mediated immune response
An immune response mediated by immunoglobulins, whether cell-bound or in solution.
sterol metabolic process
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
death
A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.
protein processing
Any protein maturation process achieved by the cleavage of peptide bonds.
aromatic compound catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
B cell mediated immunity
Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
carboxylic acid metabolic process
The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
regulation of blood coagulation
Any process that modulates the frequency, rate or extent of blood coagulation.
positive regulation of blood coagulation
Any process that activates or increases the frequency, rate or extent of blood coagulation.
negative regulation of blood coagulation
Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.
regulation of response to external stimulus
Any process that modulates the frequency, rate or extent of a response to an external stimulus.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
monocarboxylic acid metabolic process
The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
wound healing
The series of events that restore integrity to a damaged tissue, following an injury.
cellular ketone metabolic process
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
response to chemical stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
homeostatic process
Any biological process involved in the maintenance of an internal steady-state.
fibrinolysis
An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots.
macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
oxoacid metabolic process
The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
cellular amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular lipid metabolic process
The chemical reactions and pathways involving lipids, as carried out by individual cells.
small molecule metabolic process
The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
small molecule biosynthetic process
The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.
innate immune response
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
carboxylic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
carboxylic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
negative regulation of biological process
Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of response to stimulus
Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
chemical homeostasis
Any biological process involved in the maintenance of an internal steady-state of a chemical.
regulation of immune response
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
coagulation
The process by which a fluid solution, or part of it, changes into a solid or semisolid mass.
regulation of coagulation
Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.
positive regulation of coagulation
Any process that activates or increases the frequency, rate or extent of coagulation.
regulation of body fluid levels
Any process that modulates the levels of body fluids.
response to stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
cofactor metabolic process
The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
positive regulation of multicellular organismal process
Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
negative regulation of multicellular organismal process
Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
protein maturation
Any process leading to the attainment of the full functional capacity of a protein.
response to protein stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus.
regulation of fibrinolysis
Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
negative regulation of fibrinolysis
Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
lipid homeostasis
Any process involved in the maintenance of an internal steady-state of lipid within an organism or cell.
regulation of wound healing
Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
regulation of biological quality
Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
regulation of response to stress
Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
all
NA
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
cell death
A biological process that results in permanent cessation of all vital functions of a cell.
positive regulation of immune system process
Any process that activates or increases the frequency, rate, or extent of an immune system process.
positive regulation of multicellular organismal process
Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
negative regulation of multicellular organismal process
Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
regulation of immune system process
Any process that modulates the frequency, rate, or extent of an immune system process.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
negative regulation of biological process
Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
immune response
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
regulation of response to stimulus
Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
organic acid metabolic process
The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
cellular ketone metabolic process
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
small molecule biosynthetic process
The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
positive regulation of immune system process
Any process that activates or increases the frequency, rate, or extent of an immune system process.
immune effector process
Any process of the immune system that occurs as part of an immune response.
regulation of immune response
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
regulation of coagulation
Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.
positive regulation of multicellular organismal process
Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
negative regulation of multicellular organismal process
Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
positive regulation of coagulation
Any process that activates or increases the frequency, rate or extent of coagulation.
negative regulation of coagulation
Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
regulation of immune response
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
negative regulation of fibrinolysis
Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
regulation of response to stress
Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
regulation of response to external stimulus
Any process that modulates the frequency, rate or extent of a response to an external stimulus.
response to unfolded protein
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
regulation of body fluid levels
Any process that modulates the levels of body fluids.
cellular amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
organic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
protein maturation
Any process leading to the attainment of the full functional capacity of a protein.
organic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
aromatic compound catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
oxoacid metabolic process
The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
lipid biosynthetic process
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
cellular lipid metabolic process
The chemical reactions and pathways involving lipids, as carried out by individual cells.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
activation of immune response
Any process that initiates an immune response.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
complement activation, alternative pathway
Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
negative regulation of blood coagulation
Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.
negative regulation of coagulation
Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.
regulation of blood coagulation
Any process that modulates the frequency, rate or extent of blood coagulation.
positive regulation of coagulation
Any process that activates or increases the frequency, rate or extent of coagulation.
positive regulation of blood coagulation
Any process that activates or increases the frequency, rate or extent of blood coagulation.
blood coagulation
The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
regulation of blood coagulation
Any process that modulates the frequency, rate or extent of blood coagulation.
innate immune response
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
inflammatory response
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
cellular amino acid catabolic process
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
aromatic amino acid family metabolic process
The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
aromatic amino acid family catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
steroid biosynthetic process
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
sterol metabolic process
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
B cell mediated immunity
Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
complement activation, classical pathway
Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
positive regulation of blood coagulation
Any process that activates or increases the frequency, rate or extent of blood coagulation.
negative regulation of blood coagulation
Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.
negative regulation of fibrinolysis
Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
regulation of blood coagulation
Any process that modulates the frequency, rate or extent of blood coagulation.
blood coagulation
The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
regulation of wound healing
Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
response to unfolded protein
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
aromatic amino acid family catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
cellular amino acid catabolic process
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
carboxylic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
carboxylic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
regulation of fibrinolysis
Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
negative regulation of fibrinolysis
Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
activation of plasma proteins involved in acute inflammatory response
Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
fatty acid metabolic process
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
humoral immune response mediated by circulating immunoglobulin
An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
endoplasmic reticulum
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
peroxisome
A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
membrane attack complex
A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
extracellular space
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
cytoplasm
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum membrane
The lipid bilayer surrounding the endoplasmic reticulum.
stored secretory granule
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
endomembrane system
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
pore complex
Any small opening in a membrane that allows the passage of gases and/or liquids.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
integral to endoplasmic reticulum membrane
Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
organelle membrane
The lipid bilayer surrounding an organelle.
platelet alpha granule
A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).
platelet alpha granule lumen
The volume enclosed by the membrane of the platelet alpha granule.
intrinsic to membrane
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intrinsic to endoplasmic reticulum membrane
Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intrinsic to organelle membrane
Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
integral to organelle membrane
Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
membrane-enclosed lumen
The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
vesicle
Any small, fluid-filled, spherical organelle enclosed by membrane or protein.
vesicle lumen
The volume enclosed by the membrane or protein that forms a vesicle.
membrane-bounded vesicle
Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
nuclear membrane-endoplasmic reticulum network
The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.
microbody
Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
organelle lumen
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
protein complex
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
cytoplasmic membrane-bounded vesicle lumen
The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.
subsynaptic reticulum
An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
all
NA
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
organelle lumen
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
organelle membrane
The lipid bilayer surrounding an organelle.
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
intrinsic to organelle membrane
Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
organelle membrane
The lipid bilayer surrounding an organelle.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
nuclear membrane-endoplasmic reticulum network
The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
endoplasmic reticulum membrane
The lipid bilayer surrounding the endoplasmic reticulum.
nuclear membrane-endoplasmic reticulum network
The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
vesicle lumen
The volume enclosed by the membrane or protein that forms a vesicle.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
intrinsic to endoplasmic reticulum membrane
Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
endoplasmic reticulum membrane
The lipid bilayer surrounding the endoplasmic reticulum.
intrinsic to endoplasmic reticulum membrane
Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
cytoplasmic membrane-bounded vesicle lumen
The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
endoplasmic reticulum membrane
The lipid bilayer surrounding the endoplasmic reticulum.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
microbody
Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
subsynaptic reticulum
An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
intrinsic to organelle membrane
Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
membrane attack complex
A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
cytoplasmic membrane-bounded vesicle lumen
The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
integral to endoplasmic reticulum membrane
Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
pore complex
Any small opening in a membrane that allows the passage of gases and/or liquids.
integral to organelle membrane
Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
membrane attack complex
A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
platelet alpha granule lumen
The volume enclosed by the membrane of the platelet alpha granule.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
serine-type endopeptidase activity
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
catalytic activity
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
endopeptidase activity
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
serine-type peptidase activity
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
peptidase activity
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
enzyme inhibitor activity
Stops, prevents or reduces the activity of an enzyme.
endopeptidase inhibitor activity
Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
binding
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
folic acid binding
Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
oxidoreductase activity
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
lipid binding
Interacting selectively and non-covalently with a lipid.
peptidase activity, acting on L-amino acid peptides
Catalysis of the hydrolysis of peptide bonds formed between L-amino acids.
endopeptidase regulator activity
Modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
amino acid binding
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
oxidoreductase activity, acting on CH-OH group of donors
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
hydrolase activity
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
lyase activity
Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
carbon-sulfur lyase activity
Catalysis of the elimination of H2S or substituted H2S.
peptidase inhibitor activity
Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
serine hydrolase activity
Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
vitamin binding
Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
pyridoxal phosphate binding
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
enzyme regulator activity
Modulates the activity of an enzyme.
carboxylic acid binding
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
monocarboxylic acid binding
Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-).
amine binding
Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.
cofactor binding
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
coenzyme binding
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
peptidase regulator activity
Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
vitamin B6 binding
Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.
all
NA
amino acid binding
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
peptidase inhibitor activity
Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
pyridoxal phosphate binding
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
folic acid binding
Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
endopeptidase inhibitor activity
Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
serine-type peptidase activity
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
serine-type endopeptidase activity
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
Id | Pvalue | ExpCount | Count | Size | Term |
---|---|---|---|---|---|
04610 | 4.225e-10 | 1.634 | 15 | 21 | Complement and coagulation cascades |
01100 | 5.430e-04 | 27.47 | 49 | 353 | Metabolic pathways |
00260 | 1.603e-03 | 1.011 | 7 | 13 | Glycine, serine and threonine metabolism |
04146 | 3.543e-03 | 2.334 | 10 | 30 | Peroxisome |
00100 | 2.151e-02 | 0.4668 | 4 | 6 | Steroid biosynthesis |
A1CFAPOBEC1 complementation factor (ENSG00000148584), score: 0.55 ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ENSG00000073734), score: 0.71 ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ENSG00000023839), score: 0.55 ABCD3ATP-binding cassette, sub-family D (ALD), member 3 (ENSG00000117528), score: 0.6 ABCG5ATP-binding cassette, sub-family G (WHITE), member 5 (ENSG00000138075), score: 0.75 ACBD5acyl-CoA binding domain containing 5 (ENSG00000107897), score: 0.54 ACO1aconitase 1, soluble (ENSG00000122729), score: 0.51 ACOT12acyl-CoA thioesterase 12 (ENSG00000172497), score: 0.6 ACSF3acyl-CoA synthetase family member 3 (ENSG00000176715), score: 0.5 ACSL5acyl-CoA synthetase long-chain family member 5 (ENSG00000197142), score: 0.52 ACSM5acyl-CoA synthetase medium-chain family member 5 (ENSG00000183549), score: 0.46 ADAP2ArfGAP with dual PH domains 2 (ENSG00000184060), score: 0.56 AGPHD1aminoglycoside phosphotransferase domain containing 1 (ENSG00000188266), score: 0.48 AGXTalanine-glyoxylate aminotransferase (ENSG00000172482), score: 0.54 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.54 ALAS1aminolevulinate, delta-, synthase 1 (ENSG00000023330), score: 0.68 ALBalbumin (ENSG00000163631), score: 0.57 ALDH2aldehyde dehydrogenase 2 family (mitochondrial) (ENSG00000111275), score: 0.5 ALDH8A1aldehyde dehydrogenase 8 family, member A1 (ENSG00000118514), score: 0.48 AMBPalpha-1-microglobulin/bikunin precursor (ENSG00000106927), score: 0.57 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.58 ANKS4Bankyrin repeat and sterile alpha motif domain containing 4B (ENSG00000175311), score: 0.49 AP3M2adaptor-related protein complex 3, mu 2 subunit (ENSG00000070718), score: -0.53 AQP8aquaporin 8 (ENSG00000103375), score: 0.82 ARCN1archain 1 (ENSG00000095139), score: 0.57 ARHGAP42Rho GTPase activating protein 42 (ENSG00000165895), score: 0.56 ASPGasparaginase homolog (S. cerevisiae) (ENSG00000166183), score: 0.5 ATG5ATG5 autophagy related 5 homolog (S. cerevisiae) (ENSG00000057663), score: 0.5 ATL2atlastin GTPase 2 (ENSG00000119787), score: 0.49 AVPR1Aarginine vasopressin receptor 1A (ENSG00000166148), score: 0.54 B4GALT2UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (ENSG00000117411), score: -0.59 BBS2Bardet-Biedl syndrome 2 (ENSG00000125124), score: -0.66 BCAR3breast cancer anti-estrogen resistance 3 (ENSG00000137936), score: 0.47 BOCBoc homolog (mouse) (ENSG00000144857), score: -0.53 C12orf72chromosome 12 open reading frame 72 (ENSG00000139160), score: 0.58 C19orf12chromosome 19 open reading frame 12 (ENSG00000131943), score: 0.56 C20orf7chromosome 20 open reading frame 7 (ENSG00000101247), score: -0.56 C2CD2C2 calcium-dependent domain containing 2 (ENSG00000157617), score: 0.59 C5complement component 5 (ENSG00000106804), score: 0.62 C5orf33chromosome 5 open reading frame 33 (ENSG00000152620), score: 0.55 C7orf23chromosome 7 open reading frame 23 (ENSG00000135185), score: 0.7 C7orf58chromosome 7 open reading frame 58 (ENSG00000106034), score: 0.58 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.61 C8Bcomplement component 8, beta polypeptide (ENSG00000021852), score: 0.63 C8Gcomplement component 8, gamma polypeptide (ENSG00000176919), score: 0.56 C9orf150chromosome 9 open reading frame 150 (ENSG00000153714), score: 0.53 CASP8caspase 8, apoptosis-related cysteine peptidase (ENSG00000064012), score: 0.53 CCBL1cysteine conjugate-beta lyase, cytoplasmic (ENSG00000171097), score: 0.52 CCBL2cysteine conjugate-beta lyase 2 (ENSG00000137944), score: 0.62 CCRL1chemokine (C-C motif) receptor-like 1 (ENSG00000129048), score: 0.52 CDO1cysteine dioxygenase, type I (ENSG00000129596), score: 0.53 CIB3calcium and integrin binding family member 3 (ENSG00000141977), score: 0.49 CKAP5cytoskeleton associated protein 5 (ENSG00000175216), score: -0.57 CLDN14claudin 14 (ENSG00000159261), score: 0.72 CMTM8CKLF-like MARVEL transmembrane domain containing 8 (ENSG00000170293), score: 0.54 CNR2cannabinoid receptor 2 (macrophage) (ENSG00000188822), score: 0.84 COPB2coatomer protein complex, subunit beta 2 (beta prime) (ENSG00000184432), score: 0.56 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.6 CPOXcoproporphyrinogen oxidase (ENSG00000080819), score: 0.67 CREB3L3cAMP responsive element binding protein 3-like 3 (ENSG00000060566), score: 0.63 CREG1cellular repressor of E1A-stimulated genes 1 (ENSG00000143162), score: 0.6 CROTcarnitine O-octanoyltransferase (ENSG00000005469), score: 0.58 CTHcystathionase (cystathionine gamma-lyase) (ENSG00000116761), score: 0.5 CYB5Acytochrome b5 type A (microsomal) (ENSG00000166347), score: 0.48 CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1 (ENSG00000172817), score: 0.59 DCLRE1ADNA cross-link repair 1A (ENSG00000198924), score: 0.5 DERL2Der1-like domain family, member 2 (ENSG00000072849), score: 0.52 DHCR2424-dehydrocholesterol reductase (ENSG00000116133), score: 0.52 DHCR77-dehydrocholesterol reductase (ENSG00000172893), score: 0.51 DMGDHdimethylglycine dehydrogenase (ENSG00000132837), score: 0.53 DNAJC22DnaJ (Hsp40) homolog, subfamily C, member 22 (ENSG00000178401), score: 0.56 DNAJC3DnaJ (Hsp40) homolog, subfamily C, member 3 (ENSG00000102580), score: 0.61 DNTTdeoxynucleotidyltransferase, terminal (ENSG00000107447), score: 0.61 DPYSL3dihydropyrimidinase-like 3 (ENSG00000113657), score: -0.61 DUSP14dual specificity phosphatase 14 (ENSG00000161326), score: -0.56 EDEM1ER degradation enhancer, mannosidase alpha-like 1 (ENSG00000134109), score: 0.63 EGFRepidermal growth factor receptor (ENSG00000146648), score: 0.6 EPB41L4Berythrocyte membrane protein band 4.1 like 4B (ENSG00000095203), score: 0.47 EPHX2epoxide hydrolase 2, cytoplasmic (ENSG00000120915), score: 0.48 ERN1endoplasmic reticulum to nucleus signaling 1 (ENSG00000178607), score: 0.63 ESR1estrogen receptor 1 (ENSG00000091831), score: 0.54 F10coagulation factor X (ENSG00000126218), score: 0.6 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.6 F9coagulation factor IX (ENSG00000101981), score: 0.51 FABP2fatty acid binding protein 2, intestinal (ENSG00000145384), score: 1 FAM105Bfamily with sequence similarity 105, member B (ENSG00000154124), score: 0.5 FAM164Afamily with sequence similarity 164, member A (ENSG00000104427), score: -0.53 FAM176Afamily with sequence similarity 176, member A (ENSG00000115363), score: 0.47 FAM59Afamily with sequence similarity 59, member A (ENSG00000141441), score: 0.48 FAR1fatty acyl CoA reductase 1 (ENSG00000197601), score: -0.64 FASNfatty acid synthase (ENSG00000169710), score: 0.47 FETUBfetuin B (ENSG00000090512), score: 0.68 FGBfibrinogen beta chain (ENSG00000171564), score: 0.57 FGGfibrinogen gamma chain (ENSG00000171557), score: 0.56 FN1fibronectin 1 (ENSG00000115414), score: 0.59 FPGSfolylpolyglutamate synthase (ENSG00000136877), score: 0.63 GCH1GTP cyclohydrolase 1 (ENSG00000131979), score: 0.53 GDF2growth differentiation factor 2 (ENSG00000128802), score: 0.66 GDPD5glycerophosphodiester phosphodiesterase domain containing 5 (ENSG00000158555), score: -0.53 GFRA1GDNF family receptor alpha 1 (ENSG00000151892), score: 0.63 GJB1gap junction protein, beta 1, 32kDa (ENSG00000169562), score: 0.49 GJB2gap junction protein, beta 2, 26kDa (ENSG00000165474), score: 0.55 GLYCTKglycerate kinase (ENSG00000168237), score: 0.5 GM2AGM2 ganglioside activator (ENSG00000196743), score: 0.47 GNAI1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (ENSG00000127955), score: -0.56 GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (ENSG00000159921), score: 0.74 GNMTglycine N-methyltransferase (ENSG00000124713), score: 0.68 GPAMglycerol-3-phosphate acyltransferase, mitochondrial (ENSG00000119927), score: 0.49 GPLD1glycosylphosphatidylinositol specific phospholipase D1 (ENSG00000112293), score: 0.74 GPR146G protein-coupled receptor 146 (ENSG00000164849), score: 0.49 H6PDhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (ENSG00000049239), score: 0.66 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.62 HAO1hydroxyacid oxidase (glycolate oxidase) 1 (ENSG00000101323), score: 0.57 HDGFRP3hepatoma-derived growth factor, related protein 3 (ENSG00000166503), score: -0.58 HEBP1heme binding protein 1 (ENSG00000013583), score: 0.51 HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (ENSG00000051108), score: 0.49 HGDhomogentisate 1,2-dioxygenase (ENSG00000113924), score: 0.49 HGFhepatocyte growth factor (hepapoietin A; scatter factor) (ENSG00000019991), score: 0.49 HMGCR3-hydroxy-3-methylglutaryl-CoA reductase (ENSG00000113161), score: 0.49 HNF4Ahepatocyte nuclear factor 4, alpha (ENSG00000101076), score: 0.5 HNRNPRheterogeneous nuclear ribonucleoprotein R (ENSG00000125944), score: -0.56 HPXhemopexin (ENSG00000110169), score: 0.56 HRGhistidine-rich glycoprotein (ENSG00000113905), score: 0.59 HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (ENSG00000044574), score: 0.47 HTRA1HtrA serine peptidase 1 (ENSG00000166033), score: -0.55 IAH1isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) (ENSG00000134330), score: 0.49 IDH1isocitrate dehydrogenase 1 (NADP+), soluble (ENSG00000138413), score: 0.48 IFT57intraflagellar transport 57 homolog (Chlamydomonas) (ENSG00000114446), score: -0.61 IGF1insulin-like growth factor 1 (somatomedin C) (ENSG00000017427), score: 0.69 IGFBP1insulin-like growth factor binding protein 1 (ENSG00000146678), score: 0.48 IGSF6immunoglobulin superfamily, member 6 (ENSG00000140749), score: 0.49 IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (ENSG00000143466), score: 0.6 IL1RAPinterleukin 1 receptor accessory protein (ENSG00000196083), score: 0.6 INHBAinhibin, beta A (ENSG00000122641), score: 0.5 IYDiodotyrosine deiodinase (ENSG00000009765), score: 0.54 JAM3junctional adhesion molecule 3 (ENSG00000166086), score: -0.71 KIFAP3kinesin-associated protein 3 (ENSG00000075945), score: -0.56 KLBklotho beta (ENSG00000134962), score: 0.63 KLF15Kruppel-like factor 15 (ENSG00000163884), score: 0.49 KLF3Kruppel-like factor 3 (basic) (ENSG00000109787), score: 0.48 KMOkynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (ENSG00000117009), score: 0.48 LAMP2lysosomal-associated membrane protein 2 (ENSG00000005893), score: 0.46 LECT2leukocyte cell-derived chemotaxin 2 (ENSG00000145826), score: 0.65 LIFRleukemia inhibitory factor receptor alpha (ENSG00000113594), score: 0.57 LIPClipase, hepatic (ENSG00000166035), score: 0.61 LOC100292202similar to solute carrier family 25, member 25 (ENSG00000148339), score: 0.53 LPIN2lipin 2 (ENSG00000101577), score: 0.53 LRIT2leucine-rich repeat, immunoglobulin-like and transmembrane domains 2 (ENSG00000204033), score: 0.55 MAN2A1mannosidase, alpha, class 2A, member 1 (ENSG00000112893), score: 0.54 MAP1Dmethionine aminopeptidase 1D (ENSG00000172878), score: 0.51 MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (ENSG00000127241), score: 0.46 MASP2mannan-binding lectin serine peptidase 2 (ENSG00000009724), score: 0.55 MAT1Amethionine adenosyltransferase I, alpha (ENSG00000151224), score: 0.65 MCM10minichromosome maintenance complex component 10 (ENSG00000065328), score: 0.85 MCRS1microspherule protein 1 (ENSG00000187778), score: -0.54 MEAF6MYST/Esa1-associated factor 6 (ENSG00000163875), score: -0.53 MIA3melanoma inhibitory activity family, member 3 (ENSG00000154305), score: 0.69 MOCOSmolybdenum cofactor sulfurase (ENSG00000075643), score: 0.68 MTTPmicrosomal triglyceride transfer protein (ENSG00000138823), score: 0.56 MUTmethylmalonyl CoA mutase (ENSG00000146085), score: 0.5 MYO1Bmyosin IB (ENSG00000128641), score: 0.47 NADKNAD kinase (ENSG00000008130), score: 0.64 NINJ1ninjurin 1 (ENSG00000131669), score: 0.51 NIPAL1NIPA-like domain containing 1 (ENSG00000163293), score: 0.68 NR1H4nuclear receptor subfamily 1, group H, member 4 (ENSG00000012504), score: 0.51 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.6 NSDHLNAD(P) dependent steroid dehydrogenase-like (ENSG00000147383), score: 0.64 NUDT12nudix (nucleoside diphosphate linked moiety X)-type motif 12 (ENSG00000112874), score: 0.5 ONECUT1one cut homeobox 1 (ENSG00000169856), score: 0.74 OTCornithine carbamoyltransferase (ENSG00000036473), score: 0.73 P2RY2purinergic receptor P2Y, G-protein coupled, 2 (ENSG00000175591), score: 0.47 PAHphenylalanine hydroxylase (ENSG00000171759), score: 0.56 PAPSS23'-phosphoadenosine 5'-phosphosulfate synthase 2 (ENSG00000198682), score: 0.5 PAQR9progestin and adipoQ receptor family member IX (ENSG00000188582), score: 0.51 PCSK9proprotein convertase subtilisin/kexin type 9 (ENSG00000169174), score: 0.59 PCTPphosphatidylcholine transfer protein (ENSG00000141179), score: 0.5 PCYOX1prenylcysteine oxidase 1 (ENSG00000116005), score: 0.47 PDIA6protein disulfide isomerase family A, member 6 (ENSG00000143870), score: 0.53 PDP1pyruvate dehyrogenase phosphatase catalytic subunit 1 (ENSG00000164951), score: -0.54 PEMTphosphatidylethanolamine N-methyltransferase (ENSG00000133027), score: 0.55 PEX16peroxisomal biogenesis factor 16 (ENSG00000121680), score: 0.51 PIK3IP1phosphoinositide-3-kinase interacting protein 1 (ENSG00000100100), score: -0.59 PIK3R3phosphoinositide-3-kinase, regulatory subunit 3 (gamma) (ENSG00000117461), score: -0.56 PLA2G12Bphospholipase A2, group XIIB (ENSG00000138308), score: 0.48 PLATplasminogen activator, tissue (ENSG00000104368), score: -0.62 PLK3polo-like kinase 3 (ENSG00000173846), score: 0.58 PM20D1peptidase M20 domain containing 1 (ENSG00000162877), score: 0.55 PPAPDC1Bphosphatidic acid phosphatase type 2 domain containing 1B (ENSG00000147535), score: 0.57 PPP1R15Bprotein phosphatase 1, regulatory (inhibitor) subunit 15B (ENSG00000158615), score: 0.52 PPP1R3Dprotein phosphatase 1, regulatory (inhibitor) subunit 3D (ENSG00000132825), score: -0.55 PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha (ENSG00000066027), score: 0.51 PRKD1protein kinase D1 (ENSG00000184304), score: -0.58 PRKD3protein kinase D3 (ENSG00000115825), score: 0.56 PRLRprolactin receptor (ENSG00000113494), score: 0.51 PROX1prospero homeobox 1 (ENSG00000117707), score: 0.47 PROZprotein Z, vitamin K-dependent plasma glycoprotein (ENSG00000126231), score: 0.65 PSEN2presenilin 2 (Alzheimer disease 4) (ENSG00000143801), score: 0.59 PSTPIP2proline-serine-threonine phosphatase interacting protein 2 (ENSG00000152229), score: 0.49 PYGLphosphorylase, glycogen, liver (ENSG00000100504), score: 0.57 QSOX1quiescin Q6 sulfhydryl oxidase 1 (ENSG00000116260), score: 0.61 RANBP10RAN binding protein 10 (ENSG00000141084), score: 0.59 RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (ENSG00000173166), score: 0.63 RBP4retinol binding protein 4, plasma (ENSG00000138207), score: 0.47 RCN2reticulocalbin 2, EF-hand calcium binding domain (ENSG00000117906), score: -0.58 RRBP1ribosome binding protein 1 homolog 180kDa (dog) (ENSG00000125844), score: 0.47 RXRAretinoid X receptor, alpha (ENSG00000186350), score: 0.55 SARDHsarcosine dehydrogenase (ENSG00000123453), score: 0.62 SCARB1scavenger receptor class B, member 1 (ENSG00000073060), score: 0.54 SCCPDHsaccharopine dehydrogenase (putative) (ENSG00000143653), score: -0.63 SCLYselenocysteine lyase (ENSG00000132330), score: 0.56 SDR42E1short chain dehydrogenase/reductase family 42E, member 1 (ENSG00000184860), score: 0.61 SEBOXSEBOX homeobox (ENSG00000109072), score: 0.51 SEC16ASEC16 homolog A (S. cerevisiae) (ENSG00000148396), score: 0.49 SEC16BSEC16 homolog B (S. cerevisiae) (ENSG00000120341), score: 0.62 SEC24DSEC24 family, member D (S. cerevisiae) (ENSG00000150961), score: 0.55 SEC61A1Sec61 alpha 1 subunit (S. cerevisiae) (ENSG00000058262), score: 0.52 SEC63SEC63 homolog (S. cerevisiae) (ENSG00000025796), score: 0.52 SEPSECSSep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase (ENSG00000109618), score: 0.54 SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (ENSG00000140093), score: 0.55 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.59 SERPINF2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 (ENSG00000167711), score: 0.47 SESTD1SEC14 and spectrin domains 1 (ENSG00000187231), score: -0.61 SGPL1sphingosine-1-phosphate lyase 1 (ENSG00000166224), score: 0.47 SLC16A10solute carrier family 16, member 10 (aromatic amino acid transporter) (ENSG00000112394), score: 0.58 SLC17A8solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 (ENSG00000179520), score: 0.71 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (ENSG00000117479), score: 0.63 SLC25A47solute carrier family 25, member 47 (ENSG00000140107), score: 0.6 SLC2A2solute carrier family 2 (facilitated glucose transporter), member 2 (ENSG00000163581), score: 0.54 SLC2A9solute carrier family 2 (facilitated glucose transporter), member 9 (ENSG00000109667), score: 0.51 SLC33A1solute carrier family 33 (acetyl-CoA transporter), member 1 (ENSG00000169359), score: 0.47 SLC35D1solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 (ENSG00000116704), score: 0.61 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.68 SLC45A3solute carrier family 45, member 3 (ENSG00000158715), score: 0.48 SLC46A1solute carrier family 46 (folate transporter), member 1 (ENSG00000076351), score: 0.58 SLC7A2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (ENSG00000003989), score: 0.55 SLC7A6solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (ENSG00000103064), score: -0.62 SLIT3slit homolog 3 (Drosophila) (ENSG00000184347), score: -0.57 SPIRE1spire homolog 1 (Drosophila) (ENSG00000134278), score: -0.58 SPP2secreted phosphoprotein 2, 24kDa (ENSG00000072080), score: 0.53 SQLEsqualene epoxidase (ENSG00000104549), score: 0.47 ST3GAL5ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (ENSG00000115525), score: 0.57 STAB2stabilin 2 (ENSG00000136011), score: 0.57 STARD5StAR-related lipid transfer (START) domain containing 5 (ENSG00000172345), score: 0.63 TAPT1transmembrane anterior posterior transformation 1 (ENSG00000169762), score: 0.48 TARSthreonyl-tRNA synthetase (ENSG00000113407), score: 0.6 TATtyrosine aminotransferase (ENSG00000198650), score: 0.68 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.63 TGDSTDP-glucose 4,6-dehydratase (ENSG00000088451), score: 0.47 TM4SF4transmembrane 4 L six family member 4 (ENSG00000169903), score: 0.63 TMEM195transmembrane protein 195 (ENSG00000187546), score: 0.64 TMEM20transmembrane protein 20 (ENSG00000176273), score: 0.69 TMEM56transmembrane protein 56 (ENSG00000152078), score: 0.56 TOMM70Atranslocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) (ENSG00000154174), score: 0.48 TOR1Atorsin family 1, member A (torsin A) (ENSG00000136827), score: 0.54 TRABDTraB domain containing (ENSG00000170638), score: 0.52 TSKUtsukushi small leucine rich proteoglycan homolog (Xenopus laevis) (ENSG00000182704), score: 0.5 TSPAN3tetraspanin 3 (ENSG00000140391), score: -0.92 TTC36tetratricopeptide repeat domain 36 (ENSG00000172425), score: 0.47 TTC39Ctetratricopeptide repeat domain 39C (ENSG00000168234), score: 0.67 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.65 VSIG4V-set and immunoglobulin domain containing 4 (ENSG00000155659), score: 0.46 XKR9XK, Kell blood group complex subunit-related family, member 9 (ENSG00000221947), score: 0.51 ZAP70zeta-chain (TCR) associated protein kinase 70kDa (ENSG00000115085), score: 0.64 ZC3H7Azinc finger CCCH-type containing 7A (ENSG00000122299), score: 0.5 ZDHHC6zinc finger, DHHC-type containing 6 (ENSG00000023041), score: 0.53 ZNF462zinc finger protein 462 (ENSG00000148143), score: -0.56 ZNF750zinc finger protein 750 (ENSG00000141579), score: 0.79 ZNF827zinc finger protein 827 (ENSG00000151612), score: -0.55
Id | species | tissue | sex | individual |
---|---|---|---|---|
mml_lv_f_ca1 | mml | lv | f | _ |
mml_lv_m_ca1 | mml | lv | m | _ |
mmu_lv_m1_ca1 | mmu | lv | m | 1 |
mmu_lv_f_ca1 | mmu | lv | f | _ |
mmu_lv_m2_ca1 | mmu | lv | m | 2 |