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metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

immune effector process

Any process of the immune system that occurs as part of an immune response.

activation of immune response

Any process that initiates an immune response.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

leukocyte mediated immunity

Any process involved in the carrying out of an immune response by a leukocyte.

lymphocyte mediated immunity

Any process involved in the carrying out of an immune response by a lymphocyte.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

carbohydrate metabolic process

The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.

monosaccharide metabolic process

The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.

glucose metabolic process

The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.

alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

oxidation reduction

The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons.

protein maturation by peptide bond cleavage

The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

glycine metabolic process

The chemical reactions and pathways involving glycine, aminoethanoic acid.

cellular amino acid derivative metabolic process

The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.

cellular biogenic amine metabolic process

The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

neutral lipid metabolic process

The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity.

acylglycerol metabolic process

The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.

triglyceride metabolic process

The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.

glycerol ether metabolic process

The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

bile acid biosynthetic process

The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.

cellular aromatic compound metabolic process

The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.

coenzyme metabolic process

The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

lipid transport

The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

humoral immune response

An immune response mediated through a body fluid.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

nervous system development

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

central nervous system development

The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.

hemostasis

The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

bile acid metabolic process

The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

serine family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

serine family amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

aromatic amino acid family metabolic process

The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

aromatic amino acid family catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

amine catabolic process

The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

glial cell differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of a glial cell.

response to organic substance

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

gene expression

The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

lipid localization

Any process by which a lipid is transported to, or maintained in, a specific location.

sterol transport

The directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

organic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

protein processing

Any protein maturation process achieved by the cleavage of peptide bonds.

organic ether metabolic process

The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds.

hexose metabolic process

The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.

aromatic compound catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

carboxylic acid metabolic process

The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

neurogenesis

Generation of cells within the nervous system.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

cholesterol transport

The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells by means of some external agent such as a transporter or pore.

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

monocarboxylic acid metabolic process

The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).

macromolecule localization

Any process by which a macromolecule is transported to, or maintained in, a specific location.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

gliogenesis

The process by which glial cells are generated. This includes the production of glial progenitors and their differentiation into mature glia.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

homeostatic process

Any biological process involved in the maintenance of an internal steady-state.

cholesterol homeostasis

Any process involved in the maintenance of an internal steady-state of cholesterol within an organism or cell.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

reverse cholesterol transport

The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism.

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

cellular carbohydrate metabolic process

The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

small molecule biosynthetic process

The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

carboxylic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

glycerolipid metabolic process

The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

astrocyte differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

chemical homeostasis

Any biological process involved in the maintenance of an internal steady-state of a chemical.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

coagulation

The process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

regulation of coagulation

Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

cofactor metabolic process

The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

lipid homeostasis

Any process involved in the maintenance of an internal steady-state of lipid within an organism or cell.

sterol homeostasis

Any process involved in the maintenance of an internal steady-state of sterol within an organism or cell.

regulation of wound healing

Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

regulation of response to stress

Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

all

NA

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

small molecule biosynthetic process

The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

immune effector process

Any process of the immune system that occurs as part of an immune response.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of coagulation

Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of response to stress

Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

organic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

organic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

aromatic compound catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

cellular carbohydrate metabolic process

The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

monosaccharide metabolic process

The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

activation of immune response

Any process that initiates an immune response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

lipid transport

The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

aromatic amino acid family metabolic process

The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

cellular biogenic amine metabolic process

The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.

aromatic amino acid family catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

acylglycerol metabolic process

The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

acylglycerol metabolic process

The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

central nervous system development

The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.

neurogenesis

Generation of cells within the nervous system.

astrocyte differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

regulation of wound healing

Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

aromatic amino acid family catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

bile acid biosynthetic process

The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

carboxylic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

serine family amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

bile acid biosynthetic process

The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.

glial cell differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of a glial cell.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

bile acid metabolic process

The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

cell fraction

A generic term for parts of cells prepared by disruptive biochemical techniques.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

peroxisome

A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

stored secretory granule

A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.

endomembrane system

A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

cytoplasmic membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

integral to endoplasmic reticulum membrane

Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

organelle membrane

The lipid bilayer surrounding an organelle.

platelet alpha granule

A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).

platelet alpha granule lumen

The volume enclosed by the membrane of the platelet alpha granule.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to endoplasmic reticulum membrane

Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to organelle membrane

Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

integral to organelle membrane

Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cytoplasmic vesicle

A vesicle formed of membrane or protein, found in the cytoplasm of a cell.

membrane-enclosed lumen

The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

vesicle

Any small, fluid-filled, spherical organelle enclosed by membrane or protein.

vesicle lumen

The volume enclosed by the membrane or protein that forms a vesicle.

membrane-bounded vesicle

Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

microbody

Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

cytoplasmic vesicle part

Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

all

NA

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

organelle membrane

The lipid bilayer surrounding an organelle.

cytoplasmic vesicle

A vesicle formed of membrane or protein, found in the cytoplasm of a cell.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intrinsic to organelle membrane

Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

cytoplasmic vesicle part

Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.

cytoplasmic membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

vesicle lumen

The volume enclosed by the membrane or protein that forms a vesicle.

cytoplasmic membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

intrinsic to endoplasmic reticulum membrane

Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

intrinsic to endoplasmic reticulum membrane

Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

cytoplasmic vesicle

A vesicle formed of membrane or protein, found in the cytoplasm of a cell.

microbody

Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

cytoplasmic vesicle part

Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

intrinsic to organelle membrane

Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

integral to endoplasmic reticulum membrane

Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

integral to organelle membrane

Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

platelet alpha granule lumen

The volume enclosed by the membrane of the platelet alpha granule.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

monooxygenase activity

Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

metal ion binding

Interacting selectively and non-covalently with any metal ion.

iron ion binding

Interacting selectively and non-covalently with iron (Fe) ions.

oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

amino acid binding

Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.

lyase activity

Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

vitamin binding

Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

carboxylic acid binding

Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

ion binding

Interacting selectively and non-covalently with ions, charged atoms or groups of atoms.

cation binding

Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge.

amine binding

Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.

transition metal ion binding

Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

cofactor binding

Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

vitamin B6 binding

Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.

all

NA

amino acid binding

Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0006082	3.718e-15	18.01	61 AARS2, ACO1, ACOT12, ACSL1, ACSL5, AFMID, AGT, AGXT, AKR1D1, ALDH6A1, ALDH8A1, AMDHD1, ASPG, ATP8B1, AVPR1A, BBOX1, BCKDHB, CCBL1, CDO1, CTH, CYP39A1, CYP7B1, DMGDH, DPYS, EHHADH, FAR1, FH, GCH1, GCLM, GGH, GLDC, GNMT, GPAM, HAL, HAO1, HAO2, HGD, HNF1A, IDH1, IGF1, KMO, LIPC, LPIN2, MAT1A, ME2, NR1H3, NR1H4, NR5A2, OTC, PAH, PCK1, PCK2, PROX1, RBP4, SARDH, SGPL1, SLC35D1, SLC7A2, SLC7A6, TAT, TDO2	228	organic acid metabolic process
GO:0019752	3.718e-15	18.01	61 AARS2, ACO1, ACOT12, ACSL1, ACSL5, AFMID, AGT, AGXT, AKR1D1, ALDH6A1, ALDH8A1, AMDHD1, ASPG, ATP8B1, AVPR1A, BBOX1, BCKDHB, CCBL1, CDO1, CTH, CYP39A1, CYP7B1, DMGDH, DPYS, EHHADH, FAR1, FH, GCH1, GCLM, GGH, GLDC, GNMT, GPAM, HAL, HAO1, HAO2, HGD, HNF1A, IDH1, IGF1, KMO, LIPC, LPIN2, MAT1A, ME2, NR1H3, NR1H4, NR5A2, OTC, PAH, PCK1, PCK2, PROX1, RBP4, SARDH, SGPL1, SLC35D1, SLC7A2, SLC7A6, TAT, TDO2	228	carboxylic acid metabolic process
GO:0043436	3.718e-15	18.01	61 AARS2, ACO1, ACOT12, ACSL1, ACSL5, AFMID, AGT, AGXT, AKR1D1, ALDH6A1, ALDH8A1, AMDHD1, ASPG, ATP8B1, AVPR1A, BBOX1, BCKDHB, CCBL1, CDO1, CTH, CYP39A1, CYP7B1, DMGDH, DPYS, EHHADH, FAR1, FH, GCH1, GCLM, GGH, GLDC, GNMT, GPAM, HAL, HAO1, HAO2, HGD, HNF1A, IDH1, IGF1, KMO, LIPC, LPIN2, MAT1A, ME2, NR1H3, NR1H4, NR5A2, OTC, PAH, PCK1, PCK2, PROX1, RBP4, SARDH, SGPL1, SLC35D1, SLC7A2, SLC7A6, TAT, TDO2	228	oxoacid metabolic process
GO:0042180	1.070e-14	18.41	61 AARS2, ACO1, ACOT12, ACSL1, ACSL5, AFMID, AGT, AGXT, AKR1D1, ALDH6A1, ALDH8A1, AMDHD1, ASPG, ATP8B1, AVPR1A, BBOX1, BCKDHB, CCBL1, CDO1, CTH, CYP39A1, CYP7B1, DMGDH, DPYS, EHHADH, FAR1, FH, GCH1, GCLM, GGH, GLDC, GNMT, GPAM, HAL, HAO1, HAO2, HGD, HNF1A, IDH1, IGF1, KMO, LIPC, LPIN2, MAT1A, ME2, NR1H3, NR1H4, NR5A2, OTC, PAH, PCK1, PCK2, PROX1, RBP4, SARDH, SGPL1, SLC35D1, SLC7A2, SLC7A6, TAT, TDO2	233	cellular ketone metabolic process
GO:0044281	1.136e-08	47.57	93 AARS2, ABCA1, ACER3, ACO1, ACOT12, ACSL1, ACSL5, ADPGK, AFMID, AGT, AGXT, AKAP12, AKR1D1, ALDH6A1, ALDH8A1, AMDHD1, ARFGAP3, ASPG, ATP8B1, AVPR1A, BBOX1, BCKDHB, CA6, CCBL1, CDO1, CRYAB, CTH, CYP2R1, CYP39A1, CYP7B1, DHTKD1, DMGDH, DPYS, EHHADH, ETNK2, FAR1, FH, GBE1, GCH1, GCLM, GGH, GK5, GLDC, GLO1, GNMT, GPAM, H6PD, HAL, HAO1, HAO2, HGD, HNF1A, IDH1, IGF1, IL6ST, KMO, LIPC, LPIN2, MAT1A, ME2, MTAP, NADK, NAPRT1, NR0B2, NR1H3, NR1H4, NR5A2, NT5E, ONECUT1, OTC, PAH, PANK1, PCK1, PCK2, PCSK9, PDE3B, PEMT, PHKA2, PROX1, PYGL, RALGAPA1, RBP1, RBP4, SARDH, SCARB1, SGPL1, SLC35D1, SLC7A2, SLC7A6, TAT, TBC1D8B, TDO2, TTPA	602	small molecule metabolic process
GO:0044106	5.585e-08	9.007	32 AARS2, AFMID, AGXT, ALDH6A1, AMDHD1, ASPG, BBOX1, BCKDHB, CCBL1, CDO1, CTH, DMGDH, DPYS, ETNK2, GCH1, GCLM, GGH, GLDC, GNMT, HAL, HGD, KMO, LIPC, MAT1A, OTC, PAH, PEMT, SARDH, SLC7A2, SLC7A6, TAT, TDO2	114	cellular amine metabolic process
GO:0009308	1.188e-07	11.93	37 AARS2, ACER3, AFMID, AGXT, ALDH6A1, AMDHD1, ASPG, BBOX1, BCKDHB, CCBL1, CDO1, CTBS, CTH, DMGDH, DPYS, ETNK2, GCH1, GCLM, GGH, GLDC, GNMT, HAL, HGD, KMO, LIPC, LYVE1, MAT1A, NDST1, OTC, PAH, PEMT, SARDH, SLC35D1, SLC7A2, SLC7A6, TAT, TDO2	151	amine metabolic process
GO:0006519	1.570e-07	10.43	34 AARS2, AFMID, AGXT, ALDH6A1, AMDHD1, ASPG, BBOX1, BCKDHB, CCBL1, CDO1, CTH, DMGDH, DPYS, ETNK2, GCH1, GCLM, GGH, GLDC, GLO1, GNMT, HAL, HGD, IDH1, KMO, LIPC, MAT1A, OTC, PAH, PEMT, SARDH, SLC7A2, SLC7A6, TAT, TDO2	132	cellular amino acid and derivative metabolic process
GO:0006520	2.841e-07	7.111	27 AARS2, AFMID, AGXT, ALDH6A1, AMDHD1, ASPG, BCKDHB, CCBL1, CDO1, CTH, DMGDH, DPYS, GCLM, GGH, GLDC, GNMT, HAL, HGD, KMO, MAT1A, OTC, PAH, SARDH, SLC7A2, SLC7A6, TAT, TDO2	90	cellular amino acid metabolic process
GO:0051186	3.910e-07	5.373	23 ACO1, ACOT12, ALAD, ALAS1, AMBP, CIAO1, CTH, FH, GCH1, GCLM, GLO1, GPAM, GPHN, H6PD, HNF1A, HPX, IDH1, KMO, MOCOS, NADK, NAPRT1, PANK1, TDO2	68	cofactor metabolic process
GO:0016054	5.554e-07	3.793	19 ACSL5, AFMID, AKR1D1, ALDH6A1, AMDHD1, BCKDHB, CDO1, CYP39A1, DMGDH, GLDC, HAL, HAO1, HAO2, HGD, KMO, PAH, SARDH, TAT, TDO2	48	organic acid catabolic process
GO:0046395	5.554e-07	3.793	19 ACSL5, AFMID, AKR1D1, ALDH6A1, AMDHD1, BCKDHB, CDO1, CYP39A1, DMGDH, GLDC, HAL, HAO1, HAO2, HGD, KMO, PAH, SARDH, TAT, TDO2	48	carboxylic acid catabolic process
GO:0032787	9.365e-07	10.11	32 ACOT12, ACSL1, ACSL5, AGT, AGXT, AKR1D1, ALDH8A1, ATP8B1, AVPR1A, BBOX1, CYP39A1, CYP7B1, EHHADH, FAR1, GCH1, GNMT, GPAM, HAO1, HAO2, HNF1A, IDH1, IGF1, LIPC, LPIN2, NR1H3, NR1H4, NR5A2, PCK1, PCK2, PROX1, RBP4, SLC35D1	128	monocarboxylic acid metabolic process
GO:0009611	1.341e-06	16.67	43 AGT, ATRN, BMP2, C5, C8A, C8B, C8G, CDO1, CPB2, CYBB, F10, F2, F9, FGB, FGG, FN1, HRG, IGF1, IGFBP1, IL10RA, IL28RA, IL6ST, LY75, LYVE1, MASP1, MASP2, NDST1, NGFR, NT5E, PLAT, PROZ, SCARB1, SDC2, SERPINA10, SERPINC1, SERPINE2, SERPINF2, STAB1, TLR3, TPST1, VSIG4, VTN, XCR1	211	response to wounding
GO:0009063	1.905e-06	2.212	14 AFMID, ALDH6A1, AMDHD1, BCKDHB, CDO1, DMGDH, GLDC, HAL, HGD, KMO, PAH, SARDH, TAT, TDO2	28	cellular amino acid catabolic process
GO:0009310	3.095e-06	2.291	14 AFMID, ALDH6A1, AMDHD1, BCKDHB, CDO1, DMGDH, GLDC, HAL, HGD, KMO, PAH, SARDH, TAT, TDO2	29	amine catabolic process
GO:0009069	6.607e-06	0.5531	7 AGXT, CDO1, CTH, DMGDH, GCLM, GLDC, SARDH	7	serine family amino acid metabolic process
GO:0006629	7.512e-06	24.41	53 ABCA1, ACER3, ACOT12, ACSL1, ACSL5, AGT, AKR1D1, ALDH8A1, ASPG, ATP8B1, AVPR1A, CEPT1, CRLS1, CYP2R1, CYP39A1, CYP7B1, EHHADH, ESR1, ETNK2, FAR1, GPAM, GPLD1, HAO1, HAO2, HNF1A, IL6ST, LIPC, LPCAT3, LPIN2, MTTP, NAGA, NR0B2, NR1H3, NR1H4, NR5A2, PAFAH1B2, PAFAH2, PCK1, PCSK9, PDE3B, PEMT, PIGL, PIP5K1B, PLA2G12B, PROX1, RBP1, RBP4, SCARB1, SERINC5, SGPL1, SLC35C1, STARD5, TTPA	309	lipid metabolic process
GO:0006956	3.589e-05	0.6321	7 C5, C8A, C8B, C8G, MASP1, MASP2, VSIG4	8	complement activation
GO:0019439	3.589e-05	0.6321	7 AFMID, EPHX1, HGD, KMO, PAH, TAT, TDO2	8	aromatic compound catabolic process
GO:0006732	3.932e-05	4.03	17 ACO1, ACOT12, CTH, FH, GCH1, GCLM, GLO1, GPAM, GPHN, H6PD, IDH1, KMO, MOCOS, NADK, NAPRT1, PANK1, TDO2	51	coenzyme metabolic process
GO:0008206	4.689e-05	0.8691	8 AKR1D1, ATP8B1, CYP39A1, CYP7B1, HNF1A, NR1H4, NR5A2, PROX1	11	bile acid metabolic process
GO:0009074	5.601e-05	0.4741	6 AFMID, HGD, KMO, PAH, TAT, TDO2	6	aromatic amino acid family catabolic process
GO:0006950	8.335e-05	48.67	82 AGT, AHR, ALB, AMBP, ATMIN, ATRN, AVPR1A, BMP2, C5, C8A, C8B, C8G, CDO1, CPB2, CREB3L3, CRYAB, CYBB, DERL1, DNAJC3, EDEM1, EDEM3, EGFR, EME1, ERN1, ERP44, F10, F2, F9, FAF2, FGB, FGG, FN1, GCH1, GCLM, GPAM, GPR132, HAO1, HNF1A, HPX, HRG, IDH1, IGF1, IGFBP1, IL10RA, IL1R1, IL28RA, IL6ST, INHBA, KMO, LEAP2, LY75, LYVE1, MASP1, MASP2, NAPRT1, NDST1, NGFR, NT5E, PCSK9, PDIA5, PLAT, PROZ, PSEN2, SCAMP5, SCARB1, SDC2, SERPINA10, SERPINC1, SERPINE2, SERPINF2, SH3RF1, STAB1, STAB2, TAT, TLR3, TP53BP1, TPST1, TRAF2, TRAT1, VSIG4, VTN, XCR1	616	response to stress
GO:0002541	1.173e-04	0.7111	7 C5, C8A, C8B, C8G, MASP1, MASP2, VSIG4	9	activation of plasma proteins involved in acute inflammatory response
GO:0010033	1.494e-04	26.39	52 ACP2, ACSL5, AGXT, AVPR1A, BCKDHB, BMP2, BTRC, CDH1, CDO1, CREB3L3, CRYAB, CYP7B1, DDOST, DERL1, DNAJC3, EDEM1, EDEM3, EGFR, EIF4EBP1, EPHX1, ERN1, ERP44, ESR1, FAF2, GCH1, GGH, GPAM, HNF1A, HPX, IGF1R, IGFBP1, IHH, IL10RA, IL1R1, IL6ST, NR0B2, NR1H3, NR1H4, PCK1, PCK2, PCSK9, PDE3B, PEMT, PLAT, RBP4, SCARB1, SDC2, SERPINF2, SLIT3, TAT, TLR3, XCR1	334	response to organic substance
GO:0050817	1.733e-04	4.03	16 CPB2, F10, F2, F9, FGB, FGG, HRG, IL10RA, IL28RA, PLAT, PROZ, PSEN2, SERPINC1, SERPINE2, SERPINF2, VTN	51	coagulation
GO:0006725	2.099e-04	3.635	15 AFMID, ALDH6A1, DPYS, EPHX1, GCH1, GNMT, GPHN, HAO2, HGD, KMO, MOCOS, PAH, PEMT, TAT, TDO2	46	cellular aromatic compound metabolic process
GO:0006575	2.181e-04	4.583	17 AFMID, BBOX1, CCBL1, CDO1, CTH, DMGDH, ETNK2, GCH1, GCLM, GLO1, GNMT, IDH1, KMO, LIPC, PAH, PEMT, TDO2	58	cellular amino acid derivative metabolic process
GO:0042221	2.241e-04	41.24	71 ABCG5, ACO1, ACP2, ACSL5, AGXT, AHR, ALG2, ATRN, AVPR1A, BCKDHB, BLMH, BMP2, BTRC, C5, CDH1, CDO1, CPB2, CREB3L3, CRYAB, CYP7B1, DDOST, DERL1, DNAJC3, EDEM1, EDEM3, EGFR, EIF4EBP1, EPHX1, ERN1, ERP44, ESR1, FAF2, FGB, FGG, GCH1, GCLM, GGH, GPAM, HAO1, HNF1A, HPX, IDH1, IGF1R, IGFBP1, IHH, IL10RA, IL1R1, IL6ST, LECT2, NAPRT1, NR0B2, NR1H3, NR1H4, PCK1, PCK2, PCSK9, PDE3B, PEMT, PLAT, PSEN2, RBP4, ROBO1, SCARB1, SDC2, SERPINC1, SERPINF2, SLIT3, TAT, TLR3, TTPA, XCR1	522	response to chemical stimulus
GO:0009056	2.466e-04	32.87	60 ACO1, ACSL5, ADPGK, AFMID, AKR1D1, ALDH6A1, AMBP, AMBRA1, AMDHD1, ARFGAP3, ASPG, BCKDHB, BTRC, CDO1, CLN5, CLPX, CTBS, CYP39A1, DERL1, DHTKD1, DMGDH, DNAJC3, DPYS, EDEM1, EPHX1, ERLIN1, FBXO4, FH, GCH1, GLDC, H6PD, HAL, HAO1, HAO2, HGD, HM13, IDH1, IGF1, KMO, LIPC, LYVE1, NAGA, NCSTN, NGFR, NT5E, PAFAH1B2, PAFAH2, PAH, PCSK9, PDE3B, PLA2G12B, PSEN2, PYGL, RALGAPA1, SARDH, SCARB1, SGPL1, TAT, TBC1D8B, TDO2	416	catabolic process
GO:0006952	2.510e-04	13.83	33 AGT, ATRN, BMP2, C5, C8A, C8B, C8G, CDO1, CYBB, F2, FN1, GCH1, GPAM, HPX, IL1R1, IL28RA, IL6ST, INHBA, LEAP2, LY75, MASP1, MASP2, NDST1, NT5E, SERPINC1, SERPINF2, STAB1, STAB2, TLR3, TPST1, TRAT1, VSIG4, XCR1	175	defense response
GO:0044282	3.184e-04	12.09	30 ACSL5, ADPGK, AFMID, AKR1D1, ALDH6A1, AMDHD1, ARFGAP3, BCKDHB, CDO1, CYP39A1, DHTKD1, DMGDH, DPYS, GCH1, GLDC, H6PD, HAL, HAO1, HAO2, HGD, IGF1, KMO, NT5E, PAH, PDE3B, RALGAPA1, SARDH, TAT, TBC1D8B, TDO2	153	small molecule catabolic process
GO:0007596	4.396e-04	3.872	15 CPB2, F10, F2, F9, FGB, FGG, HRG, IL10RA, IL28RA, PLAT, PROZ, SERPINC1, SERPINE2, SERPINF2, VTN	49	blood coagulation
GO:0006066	4.429e-04	13.59	32 ABCA1, ACER3, ADPGK, AKR1D1, CRYAB, CYP39A1, CYP7B1, DHTKD1, DMGDH, ETNK2, GBE1, GCH1, GK5, GNMT, H6PD, HAO1, HNF1A, IGF1, IL6ST, LIPC, NR0B2, ONECUT1, PAH, PCK1, PCK2, PCSK9, PEMT, PHKA2, PYGL, RBP4, SCARB1, SLC35D1	172	alcohol metabolic process
GO:0006957	4.597e-04	0.3951	5 C5, C8A, C8B, C8G, VSIG4	5	complement activation, alternative pathway
GO:0007599	5.543e-04	3.951	15 CPB2, F10, F2, F9, FGB, FGG, HRG, IL10RA, IL28RA, PLAT, PROZ, SERPINC1, SERPINE2, SERPINF2, VTN	50	hemostasis
GO:0055114	6.955e-04	15.25	34 AKR1D1, ALDH6A1, ALDH8A1, BBOX1, BCKDHB, CDO1, CYBB, CYP2R1, CYP39A1, CYP7B1, DHTKD1, DMGDH, EHHADH, ENOX1, FAR1, GCLM, GLDC, H6PD, HAO1, HAO2, HGD, HSDL1, IDH1, IYD, KMO, LEPRE1, ME2, P4HTM, PAH, PDIA5, PRDX4, SARDH, TDO2, TXNDC12	193	oxidation reduction
GO:0044283	8.000e-04	14.7	33 ABCA1, ACER3, AGT, AGXT, AKAP12, AKR1D1, ALDH8A1, ATP8B1, AVPR1A, BBOX1, CDO1, CTH, CYP39A1, CYP7B1, ETNK2, FAR1, GCH1, GCLM, GNMT, HNF1A, KMO, LIPC, NAPRT1, NR1H3, NT5E, OTC, PAH, PCK1, PCK2, PROX1, PYGL, RBP4, SLC35D1	186	small molecule biosynthetic process
GO:0006954	8.045e-04	9.007	24 AGT, ATRN, BMP2, C5, C8A, C8B, C8G, CDO1, CYBB, F2, FN1, IL6ST, LY75, MASP1, MASP2, NDST1, NT5E, SERPINC1, SERPINF2, STAB1, TLR3, TPST1, VSIG4, XCR1	114	inflammatory response
GO:0016053	8.190e-04	4.583	16 AGT, AGXT, AKR1D1, AVPR1A, CDO1, CTH, CYP39A1, CYP7B1, FAR1, HNF1A, LIPC, NR1H3, OTC, PAH, PROX1, SLC35D1	58	organic acid biosynthetic process
GO:0046394	8.190e-04	4.583	16 AGT, AGXT, AKR1D1, AVPR1A, CDO1, CTH, CYP39A1, CYP7B1, FAR1, HNF1A, LIPC, NR1H3, OTC, PAH, PROX1, SLC35D1	58	carboxylic acid biosynthetic process
GO:0065008	9.882e-04	49.78	79 A1CF, ABCA1, ABCG5, AGT, AKR1D1, ALB, ALDH8A1, AQP11, AVPR1A, BMP2, CDO1, CISH, CLDN1, CLN5, CPB2, CRYAB, CTH, DERL1, ERP44, ESR1, F10, F2, F9, FBXO4, FGB, FGG, FH, FN1, FST, GAS2, GCH1, GCLM, GDF2, GPAM, HNF1A, HPX, HRG, IBTK, IGF1, IGFBP1, IL10RA, IL28RA, IL6ST, INHBA, LIPC, NOP58, NR0B2, NR5A2, OTC, PAH, PCK1, PCSK9, PDE3B, PDIA3, PDIA5, PLAT, PRDX4, PROZ, PSEN2, PYGL, RBP4, SCARB1, SERPINC1, SERPINE2, SERPINF2, SGPL1, SLC16A2, SLC30A1, SLC30A7, SLC40A1, SLIT3, SPI1, SPTB, TBX3, TLN2, TLR3, TXNDC12, VTN, XCR1	630	regulation of biological quality
GO:0006959	1.067e-03	1.58	9 C5, C8A, C8B, C8G, HPX, MASP1, MASP2, ST6GAL1, VSIG4	20	humoral immune response
GO:0050896	1.201e-03	83.67	118 ABCG5, ACO1, ACP2, ACSL5, AGT, AGXT, AHR, ALB, ALG2, AMBP, ATMIN, ATRN, AVPR1A, BCKDHB, BLMH, BMP2, BTRC, C5, C8A, C8B, C8G, CDH1, CDO1, CPB2, CREB3L3, CRYAB, CYBB, CYP7B1, DDOST, DERL1, DNAJC3, EDEM1, EDEM3, EGFR, EIF4EBP1, EME1, EPHX1, ERN1, ERP44, ESR1, F10, F2, F9, FAF2, FGB, FGG, FN1, GCH1, GCLM, GGH, GPAM, GPR132, HAO1, HNF1A, HPX, HRG, IDH1, IGF1, IGF1R, IGFBP1, IHH, IL10RA, IL1R1, IL1R2, IL28RA, IL6ST, INHBA, KMO, LCP2, LEAP2, LECT2, LRAT, LY75, LYVE1, MASP1, MASP2, NAPRT1, NDST1, NGFR, NR0B2, NR1H3, NR1H4, NT5E, PCK1, PCK2, PCSK9, PDE3B, PDIA5, PEMT, PLAT, PPEF2, PROZ, PSEN2, RBP4, ROBO1, SCAMP5, SCARB1, SDC2, SERPINA10, SERPINC1, SERPINE2, SERPINF2, SH3RF1, SLIT3, ST6GAL1, STAB1, STAB2, TAT, TGFBI, TLR3, TP53BP1, TPST1, TRAF2, TRAT1, TTPA, VSIG4, VTN, XCR1	1059	response to stimulus
GO:0042060	1.331e-03	6.953	20 CPB2, F10, F2, F9, FGB, FGG, HRG, IGF1, IGFBP1, IL10RA, IL28RA, PLAT, PROZ, SCARB1, SDC2, SERPINA10, SERPINC1, SERPINE2, SERPINF2, VTN	88	wound healing
GO:0016485	1.718e-03	2.923	12 C5, C8A, C8B, C8G, IHH, MASP1, MASP2, NCSTN, PCSK9, PSEN2, SERPINE2, VSIG4	37	protein processing
GO:0051604	1.718e-03	2.923	12 C5, C8A, C8B, C8G, IHH, MASP1, MASP2, NCSTN, PCSK9, PSEN2, SERPINE2, VSIG4	37	protein maturation
GO:0002455	1.820e-03	0.7111	6 C5, C8A, C8B, C8G, HPX, MASP2	9	humoral immune response mediated by circulating immunoglobulin
GO:0009072	1.820e-03	0.7111	6 AFMID, HGD, KMO, PAH, TAT, TDO2	9	aromatic amino acid family metabolic process
GO:0006699	1.898e-03	0.4741	5 AKR1D1, CYP39A1, CYP7B1, HNF1A, PROX1	6	bile acid biosynthetic process
GO:0006958	1.898e-03	0.4741	5 C5, C8A, C8B, C8G, MASP2	6	complement activation, classical pathway
GO:0008202	2.171e-03	6.084	18 ABCA1, AGT, AKR1D1, ATP8B1, CYP2R1, CYP39A1, CYP7B1, ESR1, HNF1A, LIPC, NR0B2, NR1H4, NR5A2, PCSK9, PROX1, SCARB1, SGPL1, STARD5	77	steroid metabolic process
GO:0051605	2.239e-03	2.133	10 C5, C8A, C8B, C8G, MASP1, MASP2, PCSK9, PSEN2, SERPINE2, VSIG4	27	protein maturation by peptide bond cleavage
GO:0002526	2.624e-03	2.607	11 C5, C8A, C8B, C8G, F2, FN1, IL6ST, MASP1, MASP2, SERPINF2, VSIG4	33	acute inflammatory response
GO:0030195	3.581e-03	0.7901	6 CPB2, F2, HRG, SERPINE2, SERPINF2, VTN	10	negative regulation of blood coagulation
GO:0006544	3.656e-03	0.3161	4 AGXT, DMGDH, GLDC, SARDH	4	glycine metabolic process
GO:0009071	3.656e-03	0.3161	4 CDO1, DMGDH, GLDC, SARDH	4	serine family amino acid catabolic process
GO:0044255	3.718e-03	16.04	33 ACER3, ACOT12, ACSL1, ACSL5, AGT, ALDH8A1, AVPR1A, CEPT1, CRLS1, EHHADH, ETNK2, FAR1, GPAM, GPLD1, HAO1, HAO2, HNF1A, IL6ST, LIPC, LPCAT3, LPIN2, NAGA, NR1H3, PCK1, PCSK9, PEMT, PIGL, PIP5K1B, RBP1, RBP4, SERINC5, SGPL1, SLC35C1	203	cellular lipid metabolic process
GO:0043691	4.883e-03	0.5531	5 ABCA1, ABCA5, HNF1A, LIPC, SCARB1	7	reverse cholesterol transport
GO:0044248	5.331e-03	27.5	48 ACO1, ACSL5, AFMID, AKR1D1, ALDH6A1, AMBP, AMBRA1, AMDHD1, ARFGAP3, BCKDHB, BTRC, CDO1, CLPX, CYP39A1, DERL1, DMGDH, DNAJC3, DPYS, EDEM1, EPHX1, ERLIN1, FBXO4, FH, GCH1, GLDC, HAL, HAO1, HAO2, HGD, HM13, IDH1, IGF1, KMO, LIPC, NAGA, NCSTN, NGFR, NT5E, PAH, PCSK9, PDE3B, PSEN2, RALGAPA1, SARDH, SGPL1, TAT, TBC1D8B, TDO2	348	cellular catabolic process
GO:0006641	5.699e-03	1.185	7 ACSL5, GPAM, IL6ST, LIPC, NR1H3, PCK1, PCSK9	15	triglyceride metabolic process
GO:0050818	5.699e-03	1.185	7 CPB2, F2, HRG, PSEN2, SERPINE2, SERPINF2, VTN	15	regulation of coagulation
GO:0042632	6.344e-03	0.8691	6 ABCA1, ABCG5, LIPC, NR5A2, PCSK9, SCARB1	11	cholesterol homeostasis
GO:0048708	6.344e-03	0.8691	6 AGT, BMP2, EGFR, F2, IL6ST, SERPINE2	11	astrocyte differentiation
GO:0050819	6.344e-03	0.8691	6 CPB2, F2, HRG, SERPINE2, SERPINF2, VTN	11	negative regulation of coagulation
GO:0055092	6.344e-03	0.8691	6 ABCA1, ABCG5, LIPC, NR5A2, PCSK9, SCARB1	11	sterol homeostasis
GO:0006006	6.376e-03	4.425	14 ADPGK, CRYAB, DHTKD1, GBE1, GNMT, H6PD, IGF1, IL6ST, ONECUT1, PCK1, PCK2, PHKA2, PYGL, RBP4	56	glucose metabolic process
GO:0050776	6.404e-03	5.531	16 AMBP, C5, C8A, C8B, C8G, HPX, IL28RA, IL6ST, MASP1, MASP2, PSEN2, RBP4, TLR3, TRAF2, TRAT1, VSIG4	70	regulation of immune response
GO:0006638	8.455e-03	1.264	7 ACSL5, GPAM, IL6ST, LIPC, NR1H3, PCK1, PCSK9	16	neutral lipid metabolic process
GO:0006639	8.455e-03	1.264	7 ACSL5, GPAM, IL6ST, LIPC, NR1H3, PCK1, PCSK9	16	acylglycerol metabolic process
GO:0006576	8.468e-03	2.528	10 AFMID, BBOX1, DMGDH, ETNK2, GCH1, KMO, LIPC, PAH, PEMT, TDO2	32	cellular biogenic amine metabolic process
GO:0050778	8.540e-03	4.03	13 C5, C8A, C8B, C8G, HPX, IL6ST, MASP1, MASP2, PSEN2, TLR3, TRAF2, TRAT1, VSIG4	51	positive regulation of immune response
GO:0005975	8.739e-03	16.2	32 ADPGK, ALG2, CRYAB, CTBS, DDOST, DHTKD1, GALNT7, GBE1, GK5, GLO1, GNMT, H6PD, IDH1, IGF1, IL6ST, KLB, LYVE1, MAGT1, MGAT5, NAGA, NDST1, NR1H4, ONECUT1, PCK1, PCK2, PHKA2, PYGL, RBP4, SDF2, SLC2A2, SLC35D1, ST6GAL1	205	carbohydrate metabolic process
GO:0050820	1.001e-02	0.6321	5 CPB2, F2, HRG, PSEN2, SERPINF2	8	positive regulation of coagulation
GO:0030193	1.032e-02	0.9482	6 CPB2, F2, HRG, SERPINE2, SERPINF2, VTN	12	regulation of blood coagulation
GO:0002253	1.061e-02	2.607	10 C5, C8A, C8B, C8G, MASP1, MASP2, PSEN2, TLR3, TRAT1, VSIG4	33	activation of immune response
GO:0006790	1.134e-02	3.635	12 CDO1, CTH, GCLM, GLO1, GNMT, IDH1, IGF1, NDST1, PEMT, SLC35D1, SULF1, TPST1	46	sulfur metabolic process
GO:0016042	1.190e-02	4.741	14 ACSL5, AKR1D1, ASPG, CYP39A1, HAO1, HAO2, LIPC, NAGA, PAFAH1B2, PAFAH2, PDE3B, PLA2G12B, SCARB1, SGPL1	60	lipid catabolic process
GO:0055088	1.210e-02	1.343	7 ABCA1, ABCG5, GPAM, LIPC, NR5A2, PCSK9, SCARB1	17	lipid homeostasis
GO:0034367	1.230e-02	0.3951	4 ABCA5, AGT, LIPC, SCARB1	5	macromolecular complex remodeling
GO:0034368	1.230e-02	0.3951	4 ABCA5, AGT, LIPC, SCARB1	5	protein-lipid complex remodeling
GO:0034369	1.230e-02	0.3951	4 ABCA5, AGT, LIPC, SCARB1	5	plasma lipoprotein particle remodeling
GO:0051917	1.230e-02	0.3951	4 CPB2, F2, HRG, SERPINF2	5	regulation of fibrinolysis
GO:0051918	1.230e-02	0.3951	4 CPB2, F2, HRG, SERPINF2	5	negative regulation of fibrinolysis
GO:0051188	1.243e-02	3.161	11 ALAD, ALAS1, CIAO1, GCH1, GCLM, GPHN, HNF1A, KMO, MOCOS, NAPRT1, PANK1	40	cofactor biosynthetic process
GO:0061041	1.584e-02	1.027	6 CPB2, F2, HRG, SERPINE2, SERPINF2, VTN	13	regulation of wound healing
GO:0002252	1.622e-02	4.346	13 C5, C8A, C8B, C8G, GPAM, HPX, IL28RA, MASP1, MASP2, RBP4, TLR3, TRAF2, VSIG4	55	immune effector process
GO:0050878	1.624e-02	6.084	16 CDO1, CPB2, F10, F2, F9, FGB, FGG, HRG, IL10RA, IL28RA, PLAT, PROZ, SERPINC1, SERPINE2, SERPINF2, VTN	77	regulation of body fluid levels
GO:0006662	1.680e-02	1.422	7 ACSL5, GPAM, IL6ST, LIPC, NR1H3, PCK1, PCSK9	18	glycerol ether metabolic process
GO:0018904	1.680e-02	1.422	7 ACSL5, GPAM, IL6ST, LIPC, NR1H3, PCK1, PCSK9	18	organic ether metabolic process
GO:0008610	1.735e-02	11.3	24 ACER3, ACSL5, AGT, AKR1D1, ALDH8A1, AVPR1A, CEPT1, CRLS1, CYP39A1, CYP7B1, ETNK2, FAR1, GPAM, HNF1A, LIPC, LPCAT3, NR1H3, PCK1, PEMT, PIGL, PROX1, SCARB1, SERINC5, STARD5	143	lipid biosynthetic process
GO:0006869	1.878e-02	4.425	13 ABCA1, ABCA5, ABCD3, ABCG5, ACSL5, ATP8B1, HNF1A, INHBA, LIPC, NR1H3, RBP4, SCARB1, STARD5	56	lipid transport
GO:0009309	1.987e-02	1.896	8 AGXT, BBOX1, CDO1, CTH, ETNK2, GCH1, OTC, PAH	24	amine biosynthetic process
GO:0015918	2.258e-02	1.501	7 ABCA1, ABCA5, ABCG5, HNF1A, LIPC, NR1H3, SCARB1	19	sterol transport
GO:0030301	2.258e-02	1.501	7 ABCA1, ABCA5, ABCG5, HNF1A, LIPC, NR1H3, SCARB1	19	cholesterol transport
GO:0006081	2.292e-02	1.106	6 AGXT, ALDH8A1, GLO1, HAO1, IDH1, RBP4	14	cellular aldehyde metabolic process
GO:0006986	2.505e-02	1.975	8 CREB3L3, DERL1, DNAJC3, EDEM1, EDEM3, ERN1, ERP44, FAF2	25	response to unfolded protein
GO:0006534	2.622e-02	0.237	3 CDO1, CTH, GCLM	3	cysteine metabolic process
GO:0006546	2.622e-02	0.237	3 DMGDH, GLDC, SARDH	3	glycine catabolic process
GO:0006558	2.622e-02	0.237	3 HGD, PAH, TAT	3	L-phenylalanine metabolic process
GO:0006559	2.622e-02	0.237	3 HGD, PAH, TAT	3	L-phenylalanine catabolic process
GO:0006569	2.622e-02	0.237	3 AFMID, KMO, TDO2	3	tryptophan catabolic process
GO:0042436	2.622e-02	0.237	3 AFMID, KMO, TDO2	3	indole derivative catabolic process
GO:0046218	2.622e-02	0.237	3 AFMID, KMO, TDO2	3	indolalkylamine catabolic process
GO:0019432	2.684e-02	0.4741	4 ACSL5, GPAM, NR1H3, PCK1	6	triglyceride biosynthetic process
GO:0019835	2.684e-02	0.4741	4 C5, C8A, C8B, C8G	6	cytolysis
GO:0030194	2.684e-02	0.4741	4 CPB2, F2, HRG, SERPINF2	6	positive regulation of blood coagulation
GO:0042730	2.684e-02	0.4741	4 CPB2, F2, HRG, SERPINF2	6	fibrinolysis
GO:0048710	2.684e-02	0.4741	4 BMP2, F2, IL6ST, SERPINE2	6	regulation of astrocyte differentiation
GO:0046486	2.793e-02	4.662	13 ACSL5, ETNK2, GPAM, GPLD1, IL6ST, LIPC, NR1H3, PCK1, PCSK9, PEMT, PIGL, PIP5K1B, SERINC5	59	glycerolipid metabolic process
GO:0006829	2.820e-02	0.7901	5 SLC30A1, SLC30A10, SLC30A7, SLC39A8, SLC39A9	10	zinc ion transport
GO:0045087	3.303e-02	4.188	12 C5, C8A, C8B, C8G, CYBB, GCH1, HPX, IL1R1, MASP1, MASP2, TLR3, VSIG4	53	innate immune response
GO:0022612	3.356e-02	3.635	11 BTRC, CDH1, CYP7B1, EGFR, ESR1, HGF, IGF1, IGF1R, ROBO1, TBX3, TWSG1	46	gland morphogenesis
GO:0023057	3.356e-02	3.635	11 AMBP, CISH, HHIP, IGF1, IGF1R, IHH, PCSK9, PDE3B, RGS18, RGS2, TRAT1	46	negative regulation of signaling process
GO:0010876	3.584e-02	4.82	13 ABCA1, ABCA5, ABCD3, ABCG5, ACSL5, ATP8B1, HNF1A, INHBA, LIPC, NR1H3, RBP4, SCARB1, STARD5	61	lipid localization
GO:0043648	3.751e-02	1.659	7 FH, IDH1, ME2, PAH, PCK1, PCK2, TAT	21	dicarboxylic acid metabolic process
GO:0000041	3.826e-02	2.133	8 SFXN3, SLC30A1, SLC30A10, SLC30A7, SLC31A1, SLC39A8, SLC39A9, SLC40A1	27	transition metal ion transport
GO:0033344	4.189e-02	0.8691	5 ABCA1, ABCA5, ABCG5, NR1H3, SCARB1	11	cholesterol efflux
GO:0042168	4.189e-02	0.8691	5 ALAD, ALAS1, AMBP, HNF1A, HPX	11	heme metabolic process
GO:0006766	4.627e-02	2.212	8 ALDH8A1, BBOX1, CYP2R1, KMO, NAPRT1, RBP1, RBP4, TTPA	28	vitamin metabolic process
GO:0035264	4.627e-02	2.212	8 AGT, ATRN, ETNK2, GPAM, IGF1, IHH, IKZF1, SGPL1	28	multicellular organism growth
GO:0031016	4.694e-02	1.738	7 HNF1A, IGF1, IGF1R, IHH, ONECUT1, PDE3B, PROX1	22	pancreas development
GO:0006749	4.739e-02	0.5531	4 CTH, GCLM, GLO1, IDH1	7	glutathione metabolic process
GO:0046460	4.739e-02	0.5531	4 ACSL5, GPAM, NR1H3, PCK1	7	neutral lipid biosynthetic process
GO:0046463	4.739e-02	0.5531	4 ACSL5, GPAM, NR1H3, PCK1	7	acylglycerol biosynthetic process

Id	Pvalue	ExpCount	Count	Size	Term
GO:0044432	1.014e-08	17.64	48 ACER3, ACSL1, ACSL5, CEPT1, CREB3L3, CYP2R1, CYP39A1, CYP7B1, DDOST, DERL1, DNAJC3, EDEM1, EDEM3, EPHX1, ERGIC1, ERLIN1, ERN1, ERP44, GJB1, H6PD, HM13, LPCAT3, LPIN2, LRAT, MAGT1, MFSD2A, MINPP1, MTDH, P4HTM, PDIA3, PDIA5, PEMT, PIGL, PPIB, PSEN2, RHBDF2, SEC16B, SEC23A, SEC24D, SEC61A1, SERINC5, SGPL1, SLC33A1, SLC35D1, SSR3, TLR3, TMED5, TXNDC12	227	endoplasmic reticulum part
GO:0071212	1.908e-08	18.58	49 ACER3, ACSL1, ACSL5, CEPT1, CREB3L3, CYP2R1, CYP39A1, CYP7B1, DDOST, DERL1, DNAJC3, EDEM1, EDEM3, EPHX1, ERGIC1, ERLIN1, ERN1, ERP44, GJB1, H6PD, HM13, LPCAT3, LPIN2, LRAT, MAGT1, MFSD2A, MINPP1, MTDH, P4HTM, PCSK9, PDIA3, PDIA5, PEMT, PIGL, PPIB, PSEN2, RHBDF2, SEC16B, SEC23A, SEC24D, SEC61A1, SERINC5, SGPL1, SLC33A1, SLC35D1, SSR3, TLR3, TMED5, TXNDC12	239	subsynaptic reticulum
GO:0005783	1.445e-07	27.67	61 A1CF, ACER3, ACO1, ACSL1, ACSL5, AQP11, CEPT1, CLN5, CREB3L3, CYP2R1, CYP39A1, CYP7B1, DDOST, DERL1, DNAJC3, EDEM1, EDEM3, EPHX1, ERGIC1, ERLIN1, ERN1, ERP44, FAF2, GJB1, H6PD, HM13, KIFAP3, LEPRE1, LPCAT3, LPIN2, LRAT, MAGT1, MFSD2A, MINPP1, MTDH, MTTP, NCSTN, P4HTM, PCSK9, PDE3B, PDIA3, PDIA5, PEMT, PIGL, PLA2G12B, PPIB, PSEN2, RHBDF2, SEC16B, SEC23A, SEC24D, SEC61A1, SERINC5, SGPL1, SLC33A1, SLC35D1, SSR3, SULF1, TLR3, TMED5, TXNDC12	356	endoplasmic reticulum
GO:0005789	3.533e-07	15.39	41 ACER3, ACSL1, ACSL5, CEPT1, CREB3L3, CYP2R1, CYP39A1, CYP7B1, DDOST, DERL1, DNAJC3, EDEM1, EPHX1, ERGIC1, ERLIN1, ERN1, ERP44, GJB1, HM13, LPCAT3, LPIN2, LRAT, MAGT1, MFSD2A, MTDH, P4HTM, PEMT, PIGL, PSEN2, RHBDF2, SEC16B, SEC23A, SEC24D, SEC61A1, SERINC5, SGPL1, SLC33A1, SLC35D1, SSR3, TLR3, TMED5	198	endoplasmic reticulum membrane
GO:0044444	5.048e-07	143.3	197 A1CF, AARS2, ABCA1, ABCA5, ABCD3, ACER3, ACO1, ACOT12, ACP2, ACSL1, ACSL5, ACSS3, AFMID, AGT, AGXT, AK2, AKAP12, AKR1D1, ALAD, ALAS1, ALB, ALDH6A1, ALG2, AMBRA1, AMDHD1, ANK2, AP3M2, AQP11, ARCN1, ARFGAP3, AVPR1A, BBOX1, BCKDHB, BTRC, CBY1, CCBL1, CDH1, CDO1, CEPT1, CLINT1, CLN5, CLPX, CREB3L3, CRLS1, CRYAB, CTBS, CYBB, CYP2R1, CYP39A1, CYP7B1, DDOST, DENND5A, DERL1, DHDPSL, DHTKD1, DMGDH, DNAJC3, DPYS, ECHDC3, EDEM1, EDEM3, EGFR, EHHADH, EIF4EBP1, EPHX1, EPN2, ERGIC1, ERLIN1, ERN1, ERP44, FAF2, FAM3C, FAM82A2, FAM82B, FAR1, FGB, FGG, FH, FN1, FZD5, GALNT7, GBE1, GCH1, GCLM, GGH, GJB1, GLDC, GLYCTK, GNMT, GPAM, H6PD, HAL, HAO1, HAO2, HEBP1, HGF, HM13, HRG, HSDL1, IDH1, IGF1, KIDINS220, KIFAP3, KMO, LCP2, LEPRE1, LPCAT3, LPIN2, LRAT, MAGT1, ME2, MFSD2A, MGAT5, MINPP1, MRPS30, MTDH, MTMR2, MTTP, NADK, NAGA, NAPRT1, NCSTN, NDST1, NGFR, NUDT12, NUDT19, OTC, P4HTM, PANK1, PARD6A, PCK1, PCK2, PCSK9, PDE12, PDE1A, PDE3B, PDE7A, PDIA3, PDIA5, PEMT, PEX11A, PHKA2, PIGL, PLA2G12B, PLAT, PPIB, PRDX4, PRKD1, PSEN2, PTPN6, RAB33B, RALGAPA1, RANBP10, RHBDF2, SARDH, SCAMP2, SCAMP5, SEC16B, SEC23A, SEC24D, SEC61A1, SERINC5, SERPINE2, SERPINF2, SFXN3, SGPL1, SH3RF1, SLC15A4, SLC17A5, SLC25A19, SLC25A25, SLC25A47, SLC2A2, SLC30A7, SLC33A1, SLC35C1, SLC35D1, SLC40A1, SLIT3, SPIRE1, SPTB, SSR3, ST6GAL1, STARD5, SULF1, TAT, TDO2, TLR3, TMED5, TMEM33, TMEM55A, TPST1, TRAF2, TTPA, TXNDC12, UPB1, USO1	1844	cytoplasmic part
GO:0042175	7.915e-07	15.86	41 ACER3, ACSL1, ACSL5, CEPT1, CREB3L3, CYP2R1, CYP39A1, CYP7B1, DDOST, DERL1, DNAJC3, EDEM1, EPHX1, ERGIC1, ERLIN1, ERN1, ERP44, GJB1, HM13, LPCAT3, LPIN2, LRAT, MAGT1, MFSD2A, MTDH, P4HTM, PEMT, PIGL, PSEN2, RHBDF2, SEC16B, SEC23A, SEC24D, SEC61A1, SERINC5, SGPL1, SLC33A1, SLC35D1, SSR3, TLR3, TMED5	204	nuclear membrane-endoplasmic reticulum network
GO:0005615	1.087e-05	17.57	41 AGT, ALB, ATRN, BMP2, C5, C8A, C8B, CPB2, EGFR, ENOX1, F2, FGB, FGG, FN1, GAS6, GDF2, GGH, HABP2, HGF, HPX, IGF1, IGFBP1, IHH, IL6ST, INHBA, LECT2, LIPC, MASP1, PCSK9, PLAT, PRDX4, RBP4, SDF2, SERPINC1, SERPINE2, SERPINF2, SLIT3, SULF1, TGFBI, TWSG1, VTN	226	extracellular space
GO:0031091	2.011e-04	1.477	9 ALB, FGB, FGG, FN1, HGF, HRG, IGF1, SERPINE2, SERPINF2	19	platelet alpha granule
GO:0031093	2.235e-04	1.166	8 ALB, FGB, FGG, FN1, HGF, HRG, IGF1, SERPINF2	15	platelet alpha granule lumen
GO:0005737	3.477e-04	207.6	248 A1CF, AARS2, ABCA1, ABCA5, ABCD3, ACER3, ACO1, ACOT12, ACP2, ACSL1, ACSL5, ACSS3, AFMID, AGT, AGXT, AHR, AK2, AKAP12, AKR1D1, ALAD, ALAS1, ALB, ALDH6A1, ALDH8A1, ALG2, AMBRA1, AMDHD1, ANK2, AP3M2, AQP11, ARCN1, ARFGAP3, ATRN, AVPR1A, BBOX1, BCKDHB, BLMH, BMP2, BTRC, CBY1, CCBL1, CDC42BPA, CDH1, CDO1, CEPT1, CLINT1, CLN5, CLPX, COLEC10, CREB3L3, CRLS1, CRYAB, CTBS, CTH, CUEDC2, CYBB, CYP2R1, CYP39A1, CYP7B1, DDOST, DENND5A, DERL1, DHDPSL, DHTKD1, DMGDH, DNAJC3, DPYS, ECHDC3, EDEM1, EDEM3, EGFR, EHHADH, EIF4EBP1, EPB41L4A, EPB41L4B, EPHX1, EPN2, ERGIC1, ERLIN1, ERN1, ERP44, ESR1, FAF2, FAM3C, FAM82A2, FAM82B, FAR1, FBXO4, FGB, FGG, FH, FHOD3, FN1, FZD5, GALNT7, GAS2, GBE1, GCH1, GCLM, GGH, GJB1, GLDC, GLO1, GLYCTK, GNMT, GPAM, GPHN, H6PD, HAL, HAO1, HAO2, HEBP1, HGF, HHIP, HM13, HNF1A, HRG, HSDL1, IBTK, IDH1, IGF1, IKZF1, IL10RA, KIDINS220, KIFAP3, KLHL25, KLHL5, KMO, KSR1, LCP2, LECT2, LEPRE1, LPCAT3, LPIN2, LRAT, MAGT1, MARK1, ME2, MFSD2A, MGAT5, MINPP1, MKLN1, MRPS30, MTAP, MTDH, MTMR2, MTTP, NADK, NAGA, NAPRT1, NCSTN, NDST1, NGFR, NR5A2, NRBF2, NUDT12, NUDT19, OTC, P4HTM, PAFAH1B2, PAFAH2, PANK1, PARD6A, PCK1, PCK2, PCSK9, PDE12, PDE1A, PDE3B, PDE7A, PDIA3, PDIA5, PEMT, PEX11A, PHKA2, PIGL, PLA2G12B, PLAT, PPEF2, PPIB, PPP6R2, PRDX4, PRKD1, PROX1, PSEN2, PTPN6, PYGL, RAB33B, RALGAPA1, RANBP10, RAPH1, RBP1, RGS18, RHBDF2, ROBO1, RRAGD, SARDH, SCAMP2, SCAMP5, SCARB1, SCRN1, SEC16B, SEC23A, SEC24D, SEC61A1, SERINC5, SERPINE2, SERPINF2, SFXN3, SGPL1, SH3RF1, SLC15A4, SLC17A5, SLC25A19, SLC25A25, SLC25A47, SLC2A2, SLC30A7, SLC33A1, SLC35C1, SLC35D1, SLC40A1, SLC46A1, SLIT3, SPIRE1, SPTB, SSR3, ST6GAL1, STAB2, STARD5, STK40, SULF1, TAT, TBX3, TDO2, TLN2, TLR3, TMED5, TMEM33, TMEM55A, TP53BP1, TPST1, TRAF2, TTC21B, TTPA, TXNDC12, UPB1, USO1	2671	cytoplasm
GO:0031983	3.750e-04	1.244	8 ALB, FGB, FGG, FN1, HGF, HRG, IGF1, SERPINF2	16	vesicle lumen
GO:0060205	3.750e-04	1.244	8 ALB, FGB, FGG, FN1, HGF, HRG, IGF1, SERPINF2	16	cytoplasmic membrane-bounded vesicle lumen
GO:0005777	7.881e-04	2.565	11 ABCD3, ACSL1, AGXT, EHHADH, FAR1, HAO1, HAO2, IDH1, NUDT12, NUDT19, PEX11A	33	peroxisome
GO:0042579	7.881e-04	2.565	11 ABCD3, ACSL1, AGXT, EHHADH, FAR1, HAO1, HAO2, IDH1, NUDT12, NUDT19, PEX11A	33	microbody
GO:0005576	9.520e-04	41.43	67 ADPGK, AGT, ALB, AMBP, ATRN, BMP2, C5, C8A, C8B, C8G, CA6, COLEC10, COLEC11, CPB2, CREG1, EGFR, ENOX1, F10, F2, F9, FAM3C, FETUB, FGB, FGG, FN1, FST, GAS6, GDF2, GGH, GPLD1, HABP2, HGF, HHIP, HPX, HRG, IGF1, IGFBP1, IHH, IL6ST, INHBA, LAMB3, LEAP2, LECT2, LEPRE1, LIPC, MASP1, MASP2, PCSK9, PLA2G12B, PLAT, PM20D1, PRDX4, PROZ, RBP4, SDF2, SERPINA10, SERPINC1, SERPINE2, SERPINF2, SLIT3, SPP2, ST6GAL1, SULF1, TGFBI, TSKU, TWSG1, VTN	533	extracellular region
GO:0005579	1.201e-03	0.3109	4 C5, C8A, C8B, C8G	4	membrane attack complex
GO:0031090	1.842e-03	52.38	79 ABCA5, ABCD3, ACER3, ACP2, ACSL1, ACSL5, AK2, ARCN1, ARFGAP3, CEPT1, CLN5, CLPX, CREB3L3, CRLS1, CYP2R1, CYP39A1, CYP7B1, DDOST, DERL1, DNAJC3, EDEM1, EGFR, EPHX1, EPN2, ERGIC1, ERLIN1, ERN1, ERP44, FAM82A2, FAR1, FZD5, GALNT7, GJB1, GPAM, HM13, KMO, LPCAT3, LPIN2, LRAT, MAGT1, MFSD2A, MGAT5, MTDH, MTMR2, NCSTN, NDST1, OTC, P4HTM, PEMT, PEX11A, PIGL, PSEN2, RAB33B, RHBDF2, SCAMP2, SCAMP5, SCRN1, SEC16B, SEC23A, SEC24D, SEC61A1, SERINC5, SFXN3, SGPL1, SLC15A4, SLC17A5, SLC25A19, SLC25A25, SLC25A47, SLC33A1, SLC35C1, SLC35D1, SSR3, ST6GAL1, TLR3, TMED5, TMEM55A, TPST1, USO1	674	organelle membrane
GO:0044421	2.813e-03	24.87	44 AGT, ALB, ATRN, BMP2, C5, C8A, C8B, CPB2, EGFR, ENOX1, F2, FGB, FGG, FN1, GAS6, GDF2, GGH, GPLD1, HABP2, HGF, HPX, IGF1, IGFBP1, IHH, IL6ST, INHBA, LAMB3, LECT2, LEPRE1, LIPC, MASP1, PCSK9, PLAT, PRDX4, RBP4, SDF2, SERPINC1, SERPINE2, SERPINF2, SLIT3, SULF1, TGFBI, TWSG1, VTN	320	extracellular region part
GO:0030176	6.986e-03	1.865	8 ACER3, DERL1, EDEM1, ERN1, SEC61A1, SGPL1, SLC35D1, SSR3	24	integral to endoplasmic reticulum membrane
GO:0000267	7.380e-03	29.3	48 ABCA1, ABCB11, ABCC2, ABCG5, ACP2, ACSL1, AGT, ALG2, AMBP, ATP8B1, BLMH, CRYAB, CYP2R1, CYP39A1, CYP7B1, DDOST, DPYS, EPHX1, F10, F2, FGB, GCLM, GLO1, H6PD, HAL, IGF1R, LYVE1, NCSTN, NT5E, PCK1, PCK2, PDE3B, PDE7A, PEMT, PSEN2, PYGL, SCARB1, SLC16A2, SLC17A5, SLC22A7, SLC2A2, SLC33A1, SLC7A2, SLIT3, SSR3, TDO2, TPST1, USO1	377	cell fraction
GO:0031226	9.228e-03	32.88	52 ABCA1, ABCB11, ABCC2, ATP8B1, ATRN, AVPR1A, C5, C8A, C8B, C8G, CACNB2, CD82, CLDN1, CYBB, EPHA1, F10, FGFR4, FZD5, GPR56, HHIP, IGF1R, IL1R1, IL28RA, IL2RB, IL6ST, ITGA4, LGR5, LY75, LYVE1, NCSTN, NGFR, PRKD1, PSEN2, ROBO1, SCARB1, SDC2, SLC16A2, SLC17A5, SLC22A7, SLC2A2, SLC2A9, SLC31A1, SLC33A1, SLC40A1, SLC7A2, SLC7A6, SPTB, STAB1, STAB2, TLR3, TRAT1, XCR1	423	intrinsic to plasma membrane
GO:0005887	1.516e-02	32.1	50 ABCA1, ABCB11, ABCC2, ATP8B1, ATRN, AVPR1A, C5, C8A, C8B, C8G, CACNB2, CD82, CLDN1, CYBB, EPHA1, FGFR4, FZD5, GPR56, HHIP, IGF1R, IL1R1, IL28RA, IL2RB, IL6ST, ITGA4, LGR5, LY75, LYVE1, NCSTN, NGFR, PRKD1, PSEN2, ROBO1, SCARB1, SDC2, SLC16A2, SLC17A5, SLC22A7, SLC2A2, SLC2A9, SLC31A1, SLC33A1, SLC40A1, SLC7A2, SLC7A6, STAB1, STAB2, TLR3, TRAT1, XCR1	413	integral to plasma membrane
GO:0005788	1.607e-02	2.643	9 DNAJC3, EDEM3, ERP44, H6PD, MINPP1, PDIA3, PDIA5, PPIB, TXNDC12	34	endoplasmic reticulum lumen
GO:0031227	1.756e-02	2.176	8 ACER3, DERL1, EDEM1, ERN1, SEC61A1, SGPL1, SLC35D1, SSR3	28	intrinsic to endoplasmic reticulum membrane
GO:0012505	2.039e-02	41.81	61 ABCA5, ACER3, ACSL1, ACSL5, ARCN1, ARFGAP3, CEPT1, CREB3L3, CYP2R1, CYP39A1, CYP7B1, DDOST, DERL1, DNAJC3, EDEM1, EGFR, EPHX1, EPN2, ERGIC1, ERLIN1, ERN1, ERP44, FZD5, GALNT7, GJB1, HM13, LPCAT3, LPIN2, LRAT, MAGT1, MFSD2A, MGAT5, MTDH, NDST1, OIT3, P4HTM, PEMT, PIGL, PIP5K1B, PSEN2, RAB33B, RHBDF2, SCAMP2, SCAMP5, SCRN1, SEC16B, SEC23A, SEC24D, SEC61A1, SERINC5, SGPL1, SLC2A9, SLC33A1, SLC35C1, SLC35D1, SSR3, ST6GAL1, TLR3, TMED5, TPST1, USO1	538	endomembrane system
GO:0009986	2.528e-02	9.793	20 AQP11, CRYAB, F10, FGB, FGG, HHIP, HM13, IL1R1, IL2RB, IL6ST, ITGA4, PCSK9, PLAT, ROBO1, SCARB1, SERPINE2, SPTB, STAB2, SULF1, TLR3	126	cell surface
GO:0005792	2.998e-02	5.285	13 ACSL1, AMBP, CYP2R1, CYP39A1, CYP7B1, DDOST, EPHX1, F10, H6PD, IGF1R, PDE3B, SSR3, USO1	68	microsome
GO:0044425	3.652e-02	147.6	174 ABCA1, ABCA5, ABCB11, ABCC2, ABCD3, ABCG5, ACBD5, ACER3, ACP2, ACSL1, ACSL5, ALG2, ANK2, AP3M2, AQP11, ARCN1, ATP8B1, ATRN, AVPR1A, C5, C8A, C8B, C8G, CACNB2, CD302, CD82, CDC42BPA, CDH1, CEPT1, CLDN1, CLN5, CREB3L3, CRLS1, CYBB, CYP2R1, CYP39A1, CYP7B1, DDOST, DERL1, DNAJC22, DNAJC3, EDEM1, EGFR, EPB41L4A, EPB41L4B, EPHA1, EPHX1, EPN2, ERGIC1, ERLIN1, ERN1, ERP44, ESR1, F10, FAM69B, FAM82A2, FAR1, FGB, FGFR4, FGG, FZD5, GALNT7, GJB1, GNB5, GPAM, GPHN, GPR132, GPR146, GPR56, HHIP, HM13, IGF1R, IL10RA, IL1R1, IL1R2, IL28RA, IL2RB, IL6ST, ITGA4, IYD, KIAA1432, KIDINS220, KLB, KMO, LGR5, LPCAT3, LPIN2, LRAT, LRIG3, LRRC15, LY75, LYVE1, MAGT1, MARVELD3, MFSD11, MFSD2A, MGAT5, MPZL2, MTDH, NCSTN, NDST1, NGFR, NT5E, P4HTM, PAQR9, PARD6A, PCSK9, PDE3B, PEMT, PEX11A, PIGL, PPAPDC1B, PRKD1, PSEN2, RHBDF2, ROBO1, SCAMP2, SCAMP5, SCARB1, SDC2, SEC16B, SEC23A, SEC24D, SEC61A1, SERINC5, SERPINE2, SFXN3, SGPL1, SLC15A4, SLC16A10, SLC16A2, SLC17A5, SLC22A7, SLC25A19, SLC25A25, SLC25A47, SLC2A2, SLC2A9, SLC30A1, SLC30A10, SLC30A7, SLC31A1, SLC33A1, SLC35C1, SLC35D1, SLC38A4, SLC39A8, SLC39A9, SLC40A1, SLC45A3, SLC46A1, SLC7A2, SLC7A6, SPTB, SSR3, ST6GAL1, STAB1, STAB2, TLN2, TLR3, TMCO3, TMED5, TMEM135, TMEM20, TMEM33, TMEM55A, TMEM82, TPST1, TRAM2, TRAT1, VSIG4, VTN, XCR1, XKR9	1899	membrane part
GO:0042598	4.061e-02	5.518	13 ACSL1, AMBP, CYP2R1, CYP39A1, CYP7B1, DDOST, EPHX1, F10, H6PD, IGF1R, PDE3B, SSR3, USO1	71	vesicular fraction

Id	Pvalue	ExpCount	Count	Size	Term
GO:0019842	1.224e-06	4.299	20 AGXT, ALAS1, ALB, C8G, CCBL1, CTH, DHTKD1, DMGDH, GLDC, GNMT, LEPRE1, MOCOS, P4HTM, PYGL, RBP1, RBP4, SGPL1, SLC46A1, TAT, TTPA	55	vitamin binding
GO:0048037	4.189e-06	6.487	24 ACBD5, AGXT, ALAS1, ALB, ALDH6A1, CCBL1, CTH, CYBB, DHTKD1, DMGDH, EHHADH, GLDC, H6PD, HAO1, HAO2, IDH1, KMO, ME2, MOCOS, PAH, PYGL, SARDH, SGPL1, TAT	83	cofactor binding
GO:0031406	6.285e-05	4.143	17 ACBD5, AGXT, ALB, ALDH6A1, DMGDH, DPYS, GNMT, LEPRE1, NR1H4, OTC, P4HTM, PAH, PCK1, PYGL, SLC46A1, TAT, TDO2	53	carboxylic acid binding
GO:0003824	9.964e-05	139.9	185 A1CF, AARS2, ABCA1, ABCA5, ABCB11, ABCC2, ABCD3, ABCG5, ACER3, ACO1, ACOT12, ACP2, ACSL1, ACSL5, ACSS3, ADPGK, AFMID, AGXT, AK2, AKR1D1, ALAD, ALAS1, ALDH6A1, ALDH8A1, ALG2, AMDHD1, ASPG, ATP8B1, BBOX1, BCKDHB, BLMH, BMP2, BTRC, CA6, CCBL1, CDC42BPA, CDO1, CEPT1, CLPX, CPB2, CRLS1, CTBS, CTH, CYBB, CYP2R1, CYP39A1, CYP7B1, DDOST, DHDPSL, DHTKD1, DMGDH, DPYS, ECHDC3, EDEM1, EDEM3, EGFR, EHHADH, EME1, ENOX1, EPHA1, EPHX1, ERN1, ERP44, ETNK2, F10, F2, F9, FAR1, FBXO4, FGFR4, FH, GALNT7, GBE1, GCH1, GCLM, GGH, GK5, GLDC, GLO1, GLYCTK, GNB5, GNMT, GPAM, GPHN, GPLD1, H6PD, HABP2, HAL, HAO1, HAO2, HGD, HGF, HHIP, HM13, HSDL1, HYI, IDH1, IGF1R, IHH, IYD, KLB, KMO, KSR1, LEPRE1, LIPC, LPCAT3, LPIN2, LRAT, MAGT1, MARK1, MASP1, MASP2, MAT1A, ME2, MGAT5, MINPP1, MOCOS, MPPED2, MTAP, MTMR2, MYO1B, NADK, NAGA, NAPRT1, NCSTN, NDST1, NGFR, NT5E, NUDT12, NUDT19, OTC, P4HTM, PAFAH1B2, PAFAH2, PAH, PANK1, PARP6, PCK1, PCK2, PCSK9, PDE12, PDE1A, PDE3B, PDE7A, PDIA3, PDIA5, PEMT, PHKA2, PIAS1, PIGL, PIP5K1B, PLA2G12B, PLAT, PM20D1, PPAPDC1B, PPEF2, PPIB, PPIL3, PRDX4, PRKD1, PROZ, PSEN2, PTPN6, PYGL, RPP40, SARDH, SCRN1, SDF2, SGPL1, SH3RF1, ST6GAL1, STAB1, STAB2, STK40, SULF1, TAT, TDO2, TMEM55A, TPST1, TRAF2, TRAT1, TWISTNB, TXNDC12, UPB1, ZC3H12D	1790	catalytic activity
GO:0016491	1.579e-04	16.02	37 AKR1D1, ALDH6A1, ALDH8A1, BBOX1, BCKDHB, BMP2, CDO1, CYBB, CYP2R1, CYP39A1, CYP7B1, DHTKD1, DMGDH, EHHADH, ENOX1, FAR1, GCLM, GLDC, H6PD, HAO1, HAO2, HGD, HSDL1, IDH1, IYD, KMO, LEPRE1, ME2, P4HTM, PAH, PDIA5, PRDX4, SARDH, STAB1, STAB2, TDO2, TXNDC12	205	oxidoreductase activity
GO:0030170	2.159e-04	1.641	10 AGXT, ALAS1, ALB, CCBL1, CTH, GLDC, MOCOS, PYGL, SGPL1, TAT	21	pyridoxal phosphate binding
GO:0070279	2.159e-04	1.641	10 AGXT, ALAS1, ALB, CCBL1, CTH, GLDC, MOCOS, PYGL, SGPL1, TAT	21	vitamin B6 binding
GO:0005506	5.853e-04	3.517	14 AMBP, BBOX1, CDO1, CYBB, CYP2R1, CYP39A1, CYP7B1, HEBP1, LEPRE1, NT5E, P4HTM, PAH, PPEF2, TDO2	45	iron ion binding
GO:0016829	6.171e-04	5.002	17 ACO1, ALAD, BCKDHB, CA6, CCBL1, CTH, DHDPSL, EHHADH, FH, GLDC, GLO1, HAL, MOCOS, PCK1, PCK2, SGPL1, TAT	64	lyase activity
GO:0016709	3.036e-03	0.3126	4 CYP2R1, CYP39A1, CYP7B1, KMO	4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
GO:0016597	4.746e-03	1.954	9 AGXT, DMGDH, DPYS, GNMT, OTC, PAH, SLC46A1, TAT, TDO2	25	amino acid binding
GO:0004866	1.030e-02	2.657	10 AGT, AMBP, C5, FETUB, HRG, SERPINA10, SERPINC1, SERPINE2, SERPINF2, SPP2	34	endopeptidase inhibitor activity
GO:0061135	1.264e-02	2.736	10 AGT, AMBP, C5, FETUB, HRG, SERPINA10, SERPINC1, SERPINE2, SERPINF2, SPP2	35	endopeptidase regulator activity
GO:0004252	1.534e-02	2.814	10 F10, F2, F9, HABP2, HGF, MASP1, MASP2, PCSK9, PLAT, PROZ	36	serine-type endopeptidase activity
GO:0030414	1.534e-02	2.814	10 AGT, AMBP, C5, FETUB, HRG, SERPINA10, SERPINC1, SERPINE2, SERPINF2, SPP2	36	peptidase inhibitor activity
GO:0061134	1.652e-02	3.361	11 AGT, AMBP, C5, CLPX, FETUB, HRG, SERPINA10, SERPINC1, SERPINE2, SERPINF2, SPP2	43	peptidase regulator activity
GO:0020037	1.772e-02	1.485	7 AMBP, CYBB, CYP2R1, CYP39A1, CYP7B1, HEBP1, TDO2	19	heme binding
GO:0003847	2.127e-02	0.2345	3 ASPG, PAFAH1B2, PAFAH2	3	1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0050662	2.161e-02	4.612	13 ACBD5, ALDH6A1, CYBB, DHTKD1, DMGDH, EHHADH, H6PD, HAO1, HAO2, IDH1, KMO, ME2, SARDH	59	coenzyme binding
GO:0046906	3.753e-02	1.72	7 AMBP, CYBB, CYP2R1, CYP39A1, CYP7B1, HEBP1, TDO2	22	tetrapyrrole binding
GO:0008236	4.063e-02	3.283	10 F10, F2, F9, HABP2, HGF, MASP1, MASP2, PCSK9, PLAT, PROZ	42	serine-type peptidase activity
GO:0017171	4.063e-02	3.283	10 F10, F2, F9, HABP2, HGF, MASP1, MASP2, PCSK9, PLAT, PROZ	42	serine hydrolase activity
GO:0004553	4.385e-02	2.267	8 ACER3, CTBS, EDEM1, EDEM3, GBE1, KLB, NAGA, PHKA2	29	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004867	4.610e-02	1.798	7 AGT, AMBP, HRG, SERPINA10, SERPINC1, SERPINE2, SERPINF2	23	serine-type endopeptidase inhibitor activity

Id	Pvalue	ExpCount	Count	Size	Term
04610	7.865e-08	2.432	15 C5, C8A, C8B, C8G, CPB2, F10, F2, F9, FGB, FGG, MASP1, MASP2, PLAT, SERPINC1, SERPINF2	21	Complement and coagulation cascades
01100	6.129e-04	40.88	66 ACO1, ACSL1, ACSL5, ACSS3, ADPGK, AFMID, AGXT, AK2, AKR1D1, ALAD, ALAS1, ALDH6A1, ALG2, AMDHD1, BCKDHB, CDO1, CEPT1, CRLS1, CTH, DDOST, DMGDH, DPYS, EHHADH, ETNK2, FH, GALNT7, GBE1, GCH1, GCLM, GLDC, GLYCTK, GPAM, H6PD, HAL, HAO1, HAO2, HGD, HYI, IDH1, KMO, LIPC, MAT1A, MGAT5, MTAP, MTMR2, NADK, NDST1, NT5E, OTC, PAFAH1B2, PAFAH2, PAH, PANK1, PCK1, PCK2, PEMT, PIGL, PIP5K1B, PLA2G12B, SARDH, SGPL1, SLC33A1, ST6GAL1, TAT, TDO2, UPB1	353	Metabolic pathways
00260	1.946e-03	1.505	8 AGXT, ALAS1, CTH, DMGDH, GLDC, GLYCTK, GNMT, SARDH	13	Glycine, serine and threonine metabolism
04146	4.064e-03	3.474	12 ABCD3, ACSL1, ACSL5, AGXT, EHHADH, FAR1, HAO1, HAO2, IDH1, NUDT12, NUDT19, PEX11A	30	Peroxisome
00630	1.642e-02	1.158	6 ACO1, AFMID, GLYCTK, HAO1, HAO2, HYI	10	Glyoxylate and dicarboxylate metabolism

No enriched terms

No enriched terms

Entrez genes

A1CFAPOBEC1 complementation factor (ENSG00000148584), score: 0.63 AARS2alanyl-tRNA synthetase 2, mitochondrial (putative) (ENSG00000124608), score: 0.63 ABCA1ATP-binding cassette, sub-family A (ABC1), member 1 (ENSG00000165029), score: 0.67 ABCA5ATP-binding cassette, sub-family A (ABC1), member 5 (ENSG00000154265), score: -0.76 ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ENSG00000073734), score: 0.69 ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ENSG00000023839), score: 0.59 ABCD3ATP-binding cassette, sub-family D (ALD), member 3 (ENSG00000117528), score: 0.55 ABCG5ATP-binding cassette, sub-family G (WHITE), member 5 (ENSG00000138075), score: 0.62 ACBD5acyl-CoA binding domain containing 5 (ENSG00000107897), score: 0.53 ACER3alkaline ceramidase 3 (ENSG00000078124), score: 0.62 ACO1aconitase 1, soluble (ENSG00000122729), score: 0.57 ACOT12acyl-CoA thioesterase 12 (ENSG00000172497), score: 0.79 ACP2acid phosphatase 2, lysosomal (ENSG00000134575), score: 0.66 ACSL1acyl-CoA synthetase long-chain family member 1 (ENSG00000151726), score: 0.54 ACSL5acyl-CoA synthetase long-chain family member 5 (ENSG00000197142), score: 0.67 ACSS3acyl-CoA synthetase short-chain family member 3 (ENSG00000111058), score: 0.66 ADPGKADP-dependent glucokinase (ENSG00000159322), score: 0.51 AFMIDarylformamidase (ENSG00000183077), score: 0.58 AGTangiotensinogen (serpin peptidase inhibitor, clade A, member 8) (ENSG00000135744), score: 0.54 AGXTalanine-glyoxylate aminotransferase (ENSG00000172482), score: 0.79 AHRaryl hydrocarbon receptor (ENSG00000106546), score: 0.57 AK2adenylate kinase 2 (ENSG00000004455), score: 0.66 AKAP12A kinase (PRKA) anchor protein 12 (ENSG00000131016), score: -0.59 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.85 ALADaminolevulinate dehydratase (ENSG00000148218), score: 0.52 ALAS1aminolevulinate, delta-, synthase 1 (ENSG00000023330), score: 0.56 ALBalbumin (ENSG00000163631), score: 0.75 ALDH6A1aldehyde dehydrogenase 6 family, member A1 (ENSG00000119711), score: 0.5 ALDH8A1aldehyde dehydrogenase 8 family, member A1 (ENSG00000118514), score: 0.55 ALG2asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) (ENSG00000119523), score: 0.54 AMBPalpha-1-microglobulin/bikunin precursor (ENSG00000106927), score: 0.74 AMBRA1autophagy/beclin-1 regulator 1 (ENSG00000110497), score: 0.49 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.77 ANK2ankyrin 2, neuronal (ENSG00000145362), score: -0.62 ANKS4Bankyrin repeat and sterile alpha motif domain containing 4B (ENSG00000175311), score: 0.49 AP3M2adaptor-related protein complex 3, mu 2 subunit (ENSG00000070718), score: -0.67 AQP11aquaporin 11 (ENSG00000178301), score: 0.5 ARCN1archain 1 (ENSG00000095139), score: 0.67 ARFGAP3ADP-ribosylation factor GTPase activating protein 3 (ENSG00000242247), score: 0.66 ARL14ADP-ribosylation factor-like 14 (ENSG00000179674), score: 0.76 ASPGasparaginase homolog (S. cerevisiae) (ENSG00000166183), score: 0.65 ATMINATM interactor (ENSG00000166454), score: -0.61 ATP8B1ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ENSG00000081923), score: 0.63 ATRNattractin (ENSG00000088812), score: 0.61 AVPR1Aarginine vasopressin receptor 1A (ENSG00000166148), score: 0.83 BAT2L1HLA-B associated transcript 2-like 1 (ENSG00000130723), score: -0.57 BBOX1butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 (ENSG00000129151), score: 0.49 BCKDHBbranched chain keto acid dehydrogenase E1, beta polypeptide (ENSG00000083123), score: 0.54 BLMHbleomycin hydrolase (ENSG00000108578), score: 0.66 BMP2bone morphogenetic protein 2 (ENSG00000125845), score: 0.58 BTRCbeta-transducin repeat containing (ENSG00000166167), score: -0.66 C10orf47chromosome 10 open reading frame 47 (ENSG00000148426), score: 0.51 C5complement component 5 (ENSG00000106804), score: 0.81 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.8 C8Bcomplement component 8, beta polypeptide (ENSG00000021852), score: 0.53 C8Gcomplement component 8, gamma polypeptide (ENSG00000176919), score: 0.65 CA6carbonic anhydrase VI (ENSG00000131686), score: 0.57 CACNB2calcium channel, voltage-dependent, beta 2 subunit (ENSG00000165995), score: -0.58 CAMSAP1calmodulin regulated spectrin-associated protein 1 (ENSG00000130559), score: -0.62 CAND2cullin-associated and neddylation-dissociated 2 (putative) (ENSG00000144712), score: -0.56 CBY1chibby homolog 1 (Drosophila) (ENSG00000100211), score: -0.72 CCBL1cysteine conjugate-beta lyase, cytoplasmic (ENSG00000171097), score: 0.65 CD82CD82 molecule (ENSG00000085117), score: 0.68 CDC42BPACDC42 binding protein kinase alpha (DMPK-like) (ENSG00000143776), score: -0.86 CDH1cadherin 1, type 1, E-cadherin (epithelial) (ENSG00000039068), score: 0.56 CDO1cysteine dioxygenase, type I (ENSG00000129596), score: 0.66 CEPT1choline/ethanolamine phosphotransferase 1 (ENSG00000134255), score: 0.63 CIAO1cytosolic iron-sulfur protein assembly 1 (ENSG00000144021), score: 0.52 CISHcytokine inducible SH2-containing protein (ENSG00000114737), score: 0.53 CLDN1claudin 1 (ENSG00000163347), score: 0.73 CLINT1clathrin interactor 1 (ENSG00000113282), score: 0.55 CLN5ceroid-lipofuscinosis, neuronal 5 (ENSG00000102805), score: 0.54 CLPXClpX caseinolytic peptidase X homolog (E. coli) (ENSG00000166855), score: 0.52 COLEC10collectin sub-family member 10 (C-type lectin) (ENSG00000184374), score: 0.65 COLEC11collectin sub-family member 11 (ENSG00000118004), score: 0.56 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.76 CREB3L3cAMP responsive element binding protein 3-like 3 (ENSG00000060566), score: 0.68 CREG1cellular repressor of E1A-stimulated genes 1 (ENSG00000143162), score: 0.66 CRLS1cardiolipin synthase 1 (ENSG00000088766), score: 0.53 CRYABcrystallin, alpha B (ENSG00000109846), score: -0.62 CTBSchitobiase, di-N-acetyl- (ENSG00000117151), score: 0.81 CTHcystathionase (cystathionine gamma-lyase) (ENSG00000116761), score: 0.66 CUEDC2CUE domain containing 2 (ENSG00000107874), score: -0.58 CYBBcytochrome b-245, beta polypeptide (ENSG00000165168), score: 0.55 CYP2R1cytochrome P450, family 2, subfamily R, polypeptide 1 (ENSG00000186104), score: 0.6 CYP39A1cytochrome P450, family 39, subfamily A, polypeptide 1 (ENSG00000146233), score: 0.9 CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1 (ENSG00000172817), score: 0.57 CYTSBcytospin B (ENSG00000128487), score: -0.59 DDOSTdolichyl-diphosphooligosaccharide--protein glycosyltransferase (ENSG00000244038), score: 0.69 DENND5ADENN/MADD domain containing 5A (ENSG00000184014), score: -0.61 DERL1Der1-like domain family, member 1 (ENSG00000136986), score: 0.63 DHDPSLdihydrodipicolinate synthase-like, mitochondrial (ENSG00000241935), score: 0.56 DHTKD1dehydrogenase E1 and transketolase domain containing 1 (ENSG00000181192), score: 0.81 DMGDHdimethylglycine dehydrogenase (ENSG00000132837), score: 0.51 DNAJC22DnaJ (Hsp40) homolog, subfamily C, member 22 (ENSG00000178401), score: 0.58 DNAJC3DnaJ (Hsp40) homolog, subfamily C, member 3 (ENSG00000102580), score: 0.5 DPYSdihydropyrimidinase (ENSG00000147647), score: 0.52 ECHDC3enoyl CoA hydratase domain containing 3 (ENSG00000134463), score: 0.5 EDEM1ER degradation enhancer, mannosidase alpha-like 1 (ENSG00000134109), score: 0.57 EDEM3ER degradation enhancer, mannosidase alpha-like 3 (ENSG00000116406), score: 0.61 EGFRepidermal growth factor receptor (ENSG00000146648), score: 0.61 EHHADHenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (ENSG00000113790), score: 0.52 EIF4EBP1eukaryotic translation initiation factor 4E binding protein 1 (ENSG00000187840), score: 0.49 EME1essential meiotic endonuclease 1 homolog 1 (S. pombe) (ENSG00000154920), score: 0.51 ENOX1ecto-NOX disulfide-thiol exchanger 1 (ENSG00000120658), score: -0.56 EPB41L4Aerythrocyte membrane protein band 4.1 like 4A (ENSG00000129595), score: -0.58 EPB41L4Berythrocyte membrane protein band 4.1 like 4B (ENSG00000095203), score: 0.52 EPHA1EPH receptor A1 (ENSG00000146904), score: 0.73 EPHX1epoxide hydrolase 1, microsomal (xenobiotic) (ENSG00000143819), score: 0.7 EPN2epsin 2 (ENSG00000072134), score: -0.59 ERGIC1endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 (ENSG00000113719), score: 0.56 ERLIN1ER lipid raft associated 1 (ENSG00000107566), score: 0.52 ERN1endoplasmic reticulum to nucleus signaling 1 (ENSG00000178607), score: 0.55 ERP44endoplasmic reticulum protein 44 (ENSG00000023318), score: 0.56 ESR1estrogen receptor 1 (ENSG00000091831), score: 0.75 ESRP2epithelial splicing regulatory protein 2 (ENSG00000103067), score: 0.66 ESRRGestrogen-related receptor gamma (ENSG00000196482), score: -0.57 ETNK2ethanolamine kinase 2 (ENSG00000143845), score: 0.62 F10coagulation factor X (ENSG00000126218), score: 0.62 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.75 F9coagulation factor IX (ENSG00000101981), score: 0.82 FAF2Fas associated factor family member 2 (ENSG00000113194), score: 0.59 FAM3Cfamily with sequence similarity 3, member C (ENSG00000196937), score: -0.6 FAM69Bfamily with sequence similarity 69, member B (ENSG00000165716), score: -0.58 FAM82A2family with sequence similarity 82, member A2 (ENSG00000137824), score: 0.54 FAM82Bfamily with sequence similarity 82, member B (ENSG00000176623), score: 0.51 FAM83Hfamily with sequence similarity 83, member H (ENSG00000180921), score: 0.56 FAR1fatty acyl CoA reductase 1 (ENSG00000197601), score: -0.57 FBXO4F-box protein 4 (ENSG00000151876), score: 0.52 FETUBfetuin B (ENSG00000090512), score: 1 FGBfibrinogen beta chain (ENSG00000171564), score: 0.71 FGFR4fibroblast growth factor receptor 4 (ENSG00000160867), score: 0.6 FGGfibrinogen gamma chain (ENSG00000171557), score: 0.73 FHfumarate hydratase (ENSG00000091483), score: 0.5 FHOD3formin homology 2 domain containing 3 (ENSG00000134775), score: -0.57 FN1fibronectin 1 (ENSG00000115414), score: 0.8 FSTfollistatin (ENSG00000134363), score: 0.66 FZD5frizzled homolog 5 (Drosophila) (ENSG00000163251), score: 0.62 GALNT7UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) (ENSG00000109586), score: -0.56 GAS2growth arrest-specific 2 (ENSG00000148935), score: 0.62 GAS6growth arrest-specific 6 (ENSG00000183087), score: -0.63 GBE1glucan (1,4-alpha-), branching enzyme 1 (ENSG00000114480), score: 0.58 GCH1GTP cyclohydrolase 1 (ENSG00000131979), score: 0.63 GCLMglutamate-cysteine ligase, modifier subunit (ENSG00000023909), score: 0.66 GDF2growth differentiation factor 2 (ENSG00000128802), score: 0.68 GGHgamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) (ENSG00000137563), score: 0.5 GJB1gap junction protein, beta 1, 32kDa (ENSG00000169562), score: 0.57 GK5glycerol kinase 5 (putative) (ENSG00000175066), score: 0.75 GLDCglycine dehydrogenase (decarboxylating) (ENSG00000178445), score: 0.57 GLO1glyoxalase I (ENSG00000124767), score: 0.56 GLYCTKglycerate kinase (ENSG00000168237), score: 0.53 GNB5guanine nucleotide binding protein (G protein), beta 5 (ENSG00000069966), score: -0.62 GNMTglycine N-methyltransferase (ENSG00000124713), score: 0.77 GPAMglycerol-3-phosphate acyltransferase, mitochondrial (ENSG00000119927), score: 0.58 GPHNgephyrin (ENSG00000171723), score: 0.59 GPLD1glycosylphosphatidylinositol specific phospholipase D1 (ENSG00000112293), score: 0.78 GPR132G protein-coupled receptor 132 (ENSG00000183484), score: 0.63 GPR146G protein-coupled receptor 146 (ENSG00000164849), score: 0.54 GPR56G protein-coupled receptor 56 (ENSG00000205336), score: -0.67 H2AFY2H2A histone family, member Y2 (ENSG00000099284), score: -0.59 H6PDhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (ENSG00000049239), score: 0.63 HABP2hyaluronan binding protein 2 (ENSG00000148702), score: 0.58 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.85 HAO1hydroxyacid oxidase (glycolate oxidase) 1 (ENSG00000101323), score: 0.7 HAO2hydroxyacid oxidase 2 (long chain) (ENSG00000116882), score: 0.54 HEBP1heme binding protein 1 (ENSG00000013583), score: 0.71 HGDhomogentisate 1,2-dioxygenase (ENSG00000113924), score: 0.61 HGFhepatocyte growth factor (hepapoietin A; scatter factor) (ENSG00000019991), score: 0.74 HHIPhedgehog interacting protein (ENSG00000164161), score: 0.58 HM13histocompatibility (minor) 13 (ENSG00000101294), score: 0.71 HNF1AHNF1 homeobox A (ENSG00000135100), score: 0.49 HPXhemopexin (ENSG00000110169), score: 0.75 HRGhistidine-rich glycoprotein (ENSG00000113905), score: 0.74 HSDL1hydroxysteroid dehydrogenase like 1 (ENSG00000103160), score: -0.6 HYIhydroxypyruvate isomerase (putative) (ENSG00000178922), score: 0.5 IBTKinhibitor of Bruton agammaglobulinemia tyrosine kinase (ENSG00000005700), score: 0.55 IDH1isocitrate dehydrogenase 1 (NADP+), soluble (ENSG00000138413), score: 0.51 IGF1insulin-like growth factor 1 (somatomedin C) (ENSG00000017427), score: 0.69 IGF1Rinsulin-like growth factor 1 receptor (ENSG00000140443), score: -0.62 IGFBP1insulin-like growth factor binding protein 1 (ENSG00000146678), score: 0.87 IHHIndian hedgehog (ENSG00000163501), score: 0.61 IKZF1IKAROS family zinc finger 1 (Ikaros) (ENSG00000185811), score: 0.49 IL10RAinterleukin 10 receptor, alpha (ENSG00000110324), score: 0.52 IL1R1interleukin 1 receptor, type I (ENSG00000115594), score: 0.5 IL1R2interleukin 1 receptor, type II (ENSG00000115590), score: 0.51 IL28RAinterleukin 28 receptor, alpha (interferon, lambda receptor) (ENSG00000185436), score: 0.56 IL2RBinterleukin 2 receptor, beta (ENSG00000100385), score: 0.53 IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor) (ENSG00000134352), score: 0.6 INHBAinhibin, beta A (ENSG00000122641), score: 0.56 ITGA4integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (ENSG00000115232), score: 0.53 IYDiodotyrosine deiodinase (ENSG00000009765), score: 0.81 KIAA0664KIAA0664 (ENSG00000132361), score: 0.57 KIAA1432KIAA1432 (ENSG00000107036), score: 0.56 KIDINS220kinase D-interacting substrate, 220kDa (ENSG00000134313), score: -0.56 KIFAP3kinesin-associated protein 3 (ENSG00000075945), score: -0.66 KLBklotho beta (ENSG00000134962), score: 0.6 KLHL25kelch-like 25 (Drosophila) (ENSG00000183655), score: 0.53 KLHL5kelch-like 5 (Drosophila) (ENSG00000109790), score: -0.91 KMOkynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (ENSG00000117009), score: 0.61 KSR1kinase suppressor of ras 1 (ENSG00000141068), score: -0.59 LAMB3laminin, beta 3 (ENSG00000196878), score: 0.54 LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (ENSG00000043462), score: 0.51 LEAP2liver expressed antimicrobial peptide 2 (ENSG00000164406), score: 0.68 LECT2leukocyte cell-derived chemotaxin 2 (ENSG00000145826), score: 0.98 LEPRE1leucine proline-enriched proteoglycan (leprecan) 1 (ENSG00000117385), score: 0.54 LGR5leucine-rich repeat-containing G protein-coupled receptor 5 (ENSG00000139292), score: 0.49 LIPClipase, hepatic (ENSG00000166035), score: 0.63 LOC100292021similar to thioredoxin peroxidase (ENSG00000123131), score: 0.59 LOC100292202similar to solute carrier family 25, member 25 (ENSG00000148339), score: 0.51 LPCAT3lysophosphatidylcholine acyltransferase 3 (ENSG00000111684), score: 0.59 LPIN2lipin 2 (ENSG00000101577), score: 0.67 LRATlecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) (ENSG00000121207), score: 0.6 LRIG3leucine-rich repeats and immunoglobulin-like domains 3 (ENSG00000139263), score: 0.73 LRRC15leucine rich repeat containing 15 (ENSG00000172061), score: 0.61 LRRC31leucine rich repeat containing 31 (ENSG00000114248), score: 0.53 LY75lymphocyte antigen 75 (ENSG00000054219), score: 0.5 LYVE1lymphatic vessel endothelial hyaluronan receptor 1 (ENSG00000133800), score: 0.58 MAGT1magnesium transporter 1 (ENSG00000102158), score: 0.52 MARK1MAP/microtubule affinity-regulating kinase 1 (ENSG00000116141), score: -0.57 MARVELD3MARVEL domain containing 3 (ENSG00000140832), score: 0.52 MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (ENSG00000127241), score: 0.65 MASP2mannan-binding lectin serine peptidase 2 (ENSG00000009724), score: 0.77 MAT1Amethionine adenosyltransferase I, alpha (ENSG00000151224), score: 0.8 ME2malic enzyme 2, NAD(+)-dependent, mitochondrial (ENSG00000082212), score: -0.6 MFSD11major facilitator superfamily domain containing 11 (ENSG00000092931), score: 0.49 MFSD2Amajor facilitator superfamily domain containing 2A (ENSG00000168389), score: 0.58 MGAT5mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (ENSG00000152127), score: -0.62 MINPP1multiple inositol-polyphosphate phosphatase 1 (ENSG00000107789), score: 0.54 MKLN1muskelin 1, intracellular mediator containing kelch motifs (ENSG00000128585), score: 0.58 MOCOSmolybdenum cofactor sulfurase (ENSG00000075643), score: 0.6 MPPED2metallophosphoesterase domain containing 2 (ENSG00000066382), score: -0.59 MPZL2myelin protein zero-like 2 (ENSG00000149573), score: 0.51 MRPS30mitochondrial ribosomal protein S30 (ENSG00000112996), score: 0.56 MTAPmethylthioadenosine phosphorylase (ENSG00000099810), score: 0.59 MTDHmetadherin (ENSG00000147649), score: 0.49 MTMR2myotubularin related protein 2 (ENSG00000087053), score: -0.82 MTTPmicrosomal triglyceride transfer protein (ENSG00000138823), score: 0.73 MYO1Bmyosin IB (ENSG00000128641), score: 0.51 NADKNAD kinase (ENSG00000008130), score: 0.53 NAGAN-acetylgalactosaminidase, alpha- (ENSG00000198951), score: 0.74 NAPRT1nicotinate phosphoribosyltransferase domain containing 1 (ENSG00000147813), score: 0.49 NCSTNnicastrin (ENSG00000162736), score: 0.59 NDST1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 (ENSG00000070614), score: 0.54 NGFRnerve growth factor receptor (ENSG00000064300), score: 0.62 NOP58NOP58 ribonucleoprotein homolog (yeast) (ENSG00000055044), score: 0.59 NR0B2nuclear receptor subfamily 0, group B, member 2 (ENSG00000131910), score: 0.53 NR1H3nuclear receptor subfamily 1, group H, member 3 (ENSG00000025434), score: 0.55 NR1H4nuclear receptor subfamily 1, group H, member 4 (ENSG00000012504), score: 0.55 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.72 NRBF2nuclear receptor binding factor 2 (ENSG00000148572), score: 0.58 NT5E5'-nucleotidase, ecto (CD73) (ENSG00000135318), score: 0.64 NUDT12nudix (nucleoside diphosphate linked moiety X)-type motif 12 (ENSG00000112874), score: 0.7 NUDT19nudix (nucleoside diphosphate linked moiety X)-type motif 19 (ENSG00000213965), score: 0.56 OIT3oncoprotein induced transcript 3 (ENSG00000138315), score: 0.72 ONECUT1one cut homeobox 1 (ENSG00000169856), score: 0.84 OTCornithine carbamoyltransferase (ENSG00000036473), score: 0.97 P4HTMprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) (ENSG00000178467), score: -0.59 PAFAH1B2platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) (ENSG00000168092), score: -0.63 PAFAH2platelet-activating factor acetylhydrolase 2, 40kDa (ENSG00000158006), score: 0.5 PAHphenylalanine hydroxylase (ENSG00000171759), score: 0.65 PANK1pantothenate kinase 1 (ENSG00000152782), score: 0.54 PAQR9progestin and adipoQ receptor family member IX (ENSG00000188582), score: 0.55 PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans) (ENSG00000102981), score: -0.64 PARP6poly (ADP-ribose) polymerase family, member 6 (ENSG00000137817), score: -0.6 PCK1phosphoenolpyruvate carboxykinase 1 (soluble) (ENSG00000124253), score: 0.56 PCK2phosphoenolpyruvate carboxykinase 2 (mitochondrial) (ENSG00000100889), score: 0.72 PCSK9proprotein convertase subtilisin/kexin type 9 (ENSG00000169174), score: 0.57 PDE12phosphodiesterase 12 (ENSG00000174840), score: 0.49 PDE1Aphosphodiesterase 1A, calmodulin-dependent (ENSG00000115252), score: -0.58 PDE3Bphosphodiesterase 3B, cGMP-inhibited (ENSG00000152270), score: 0.54 PDE7Aphosphodiesterase 7A (ENSG00000205268), score: -0.64 PDIA3protein disulfide isomerase family A, member 3 (ENSG00000167004), score: 0.55 PDIA5protein disulfide isomerase family A, member 5 (ENSG00000065485), score: 0.53 PEMTphosphatidylethanolamine N-methyltransferase (ENSG00000133027), score: 0.72 PEX11Aperoxisomal biogenesis factor 11 alpha (ENSG00000166821), score: 0.56 PHKA2phosphorylase kinase, alpha 2 (liver) (ENSG00000044446), score: 0.53 PIAS1protein inhibitor of activated STAT, 1 (ENSG00000033800), score: -0.6 PIGLphosphatidylinositol glycan anchor biosynthesis, class L (ENSG00000108474), score: 0.5 PIP5K1Bphosphatidylinositol-4-phosphate 5-kinase, type I, beta (ENSG00000107242), score: -0.58 PLA2G12Bphospholipase A2, group XIIB (ENSG00000138308), score: 0.69 PLATplasminogen activator, tissue (ENSG00000104368), score: -0.7 PM20D1peptidase M20 domain containing 1 (ENSG00000162877), score: 0.69 PPAPDC1Bphosphatidic acid phosphatase type 2 domain containing 1B (ENSG00000147535), score: 0.67 PPEF2protein phosphatase, EF-hand calcium binding domain 2 (ENSG00000156194), score: 0.52 PPIBpeptidylprolyl isomerase B (cyclophilin B) (ENSG00000166794), score: 0.52 PPIL3peptidylprolyl isomerase (cyclophilin)-like 3 (ENSG00000240344), score: 0.53 PPP6R2protein phosphatase 6, regulatory subunit 2 (ENSG00000100239), score: 0.5 PRKD1protein kinase D1 (ENSG00000184304), score: -0.56 PROX1prospero homeobox 1 (ENSG00000117707), score: 0.54 PROZprotein Z, vitamin K-dependent plasma glycoprotein (ENSG00000126231), score: 0.79 PSEN2presenilin 2 (Alzheimer disease 4) (ENSG00000143801), score: 0.6 PTPN6protein tyrosine phosphatase, non-receptor type 6 (ENSG00000111679), score: 0.5 PYGLphosphorylase, glycogen, liver (ENSG00000100504), score: 0.66 RAB33BRAB33B, member RAS oncogene family (ENSG00000172007), score: 0.52 RALGAPA1Ral GTPase activating protein, alpha subunit 1 (catalytic) (ENSG00000174373), score: -0.6 RANBP10RAN binding protein 10 (ENSG00000141084), score: 0.62 RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (ENSG00000173166), score: 0.52 RASL11BRAS-like, family 11, member B (ENSG00000128045), score: -0.56 RBP1retinol binding protein 1, cellular (ENSG00000114115), score: 0.56 RBP4retinol binding protein 4, plasma (ENSG00000138207), score: 0.7 RGS18regulator of G-protein signaling 18 (ENSG00000150681), score: 0.8 RGS2regulator of G-protein signaling 2, 24kDa (ENSG00000116741), score: -0.59 RHBDF2rhomboid 5 homolog 2 (Drosophila) (ENSG00000129667), score: 0.49 ROBO1roundabout, axon guidance receptor, homolog 1 (Drosophila) (ENSG00000169855), score: -0.6 RPP40ribonuclease P/MRP 40kDa subunit (ENSG00000124787), score: 0.58 RRAGDRas-related GTP binding D (ENSG00000025039), score: -0.65 SARDHsarcosine dehydrogenase (ENSG00000123453), score: 0.58 SCAMP2secretory carrier membrane protein 2 (ENSG00000140497), score: 0.5 SCAMP5secretory carrier membrane protein 5 (ENSG00000198794), score: -0.6 SCARB1scavenger receptor class B, member 1 (ENSG00000073060), score: 0.79 SCRN1secernin 1 (ENSG00000136193), score: -0.61 SDC2syndecan 2 (ENSG00000169439), score: 0.8 SDF2stromal cell-derived factor 2 (ENSG00000132581), score: 0.57 SEBOXSEBOX homeobox (ENSG00000109072), score: 0.69 SEC16BSEC16 homolog B (S. cerevisiae) (ENSG00000120341), score: 0.67 SEC23ASec23 homolog A (S. cerevisiae) (ENSG00000100934), score: 0.6 SEC24DSEC24 family, member D (S. cerevisiae) (ENSG00000150961), score: 0.61 SEC61A1Sec61 alpha 1 subunit (S. cerevisiae) (ENSG00000058262), score: 0.59 SERINC5serine incorporator 5 (ENSG00000164300), score: 0.51 SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (ENSG00000140093), score: 0.72 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.78 SERPINE2serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 (ENSG00000135919), score: -0.66 SERPINF2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 (ENSG00000167711), score: 0.64 SETBP1SET binding protein 1 (ENSG00000152217), score: -0.58 SFRS18splicing factor, arginine/serine-rich 18 (ENSG00000132424), score: -0.59 SFXN3sideroflexin 3 (ENSG00000107819), score: -0.6 SGPL1sphingosine-1-phosphate lyase 1 (ENSG00000166224), score: 0.72 SH3RF1SH3 domain containing ring finger 1 (ENSG00000154447), score: -0.56 SLC15A4solute carrier family 15, member 4 (ENSG00000139370), score: 0.52 SLC16A10solute carrier family 16, member 10 (aromatic amino acid transporter) (ENSG00000112394), score: 0.65 SLC16A2solute carrier family 16, member 2 (monocarboxylic acid transporter 8) (ENSG00000147100), score: 0.6 SLC17A5solute carrier family 17 (anion/sugar transporter), member 5 (ENSG00000119899), score: 0.54 SLC22A7solute carrier family 22 (organic anion transporter), member 7 (ENSG00000137204), score: 0.55 SLC25A19solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 (ENSG00000125454), score: -0.59 SLC25A47solute carrier family 25, member 47 (ENSG00000140107), score: 0.72 SLC2A2solute carrier family 2 (facilitated glucose transporter), member 2 (ENSG00000163581), score: 0.65 SLC2A9solute carrier family 2 (facilitated glucose transporter), member 9 (ENSG00000109667), score: 0.73 SLC30A1solute carrier family 30 (zinc transporter), member 1 (ENSG00000170385), score: 0.61 SLC30A10solute carrier family 30, member 10 (ENSG00000196660), score: 0.59 SLC30A7solute carrier family 30 (zinc transporter), member 7 (ENSG00000162695), score: 0.6 SLC31A1solute carrier family 31 (copper transporters), member 1 (ENSG00000136868), score: 0.6 SLC33A1solute carrier family 33 (acetyl-CoA transporter), member 1 (ENSG00000169359), score: 0.54 SLC35C1solute carrier family 35, member C1 (ENSG00000181830), score: 0.58 SLC35D1solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 (ENSG00000116704), score: 0.57 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.82 SLC39A8solute carrier family 39 (zinc transporter), member 8 (ENSG00000138821), score: 0.57 SLC39A9solute carrier family 39 (zinc transporter), member 9 (ENSG00000029364), score: 0.77 SLC40A1solute carrier family 40 (iron-regulated transporter), member 1 (ENSG00000138449), score: 0.51 SLC45A3solute carrier family 45, member 3 (ENSG00000158715), score: 0.71 SLC46A1solute carrier family 46 (folate transporter), member 1 (ENSG00000076351), score: 0.96 SLC7A2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (ENSG00000003989), score: 0.82 SLC7A6solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (ENSG00000103064), score: -0.75 SLIT3slit homolog 3 (Drosophila) (ENSG00000184347), score: -0.58 SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 (ENSG00000082014), score: -0.66 SPI1spleen focus forming virus (SFFV) proviral integration oncogene spi1 (ENSG00000066336), score: 0.56 SPIRE1spire homolog 1 (Drosophila) (ENSG00000134278), score: -0.73 SPP2secreted phosphoprotein 2, 24kDa (ENSG00000072080), score: 0.79 SPTBspectrin, beta, erythrocytic (ENSG00000070182), score: -0.58 SSR3signal sequence receptor, gamma (translocon-associated protein gamma) (ENSG00000114850), score: 0.59 ST6GAL1ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 (ENSG00000073849), score: 0.63 STAB1stabilin 1 (ENSG00000010327), score: 0.59 STAB2stabilin 2 (ENSG00000136011), score: 0.76 STARD5StAR-related lipid transfer (START) domain containing 5 (ENSG00000172345), score: 0.9 STK40serine/threonine kinase 40 (ENSG00000196182), score: 0.59 SULF1sulfatase 1 (ENSG00000137573), score: -0.57 TATtyrosine aminotransferase (ENSG00000198650), score: 0.84 TBC1D8BTBC1 domain family, member 8B (with GRAM domain) (ENSG00000133138), score: 0.61 TBX3T-box 3 (ENSG00000135111), score: 0.56 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.76 TGFBItransforming growth factor, beta-induced, 68kDa (ENSG00000120708), score: 0.55 TLN2talin 2 (ENSG00000171914), score: -0.6 TLR3toll-like receptor 3 (ENSG00000164342), score: 0.66 TMCO3transmembrane and coiled-coil domains 3 (ENSG00000150403), score: -0.56 TMED5transmembrane emp24 protein transport domain containing 5 (ENSG00000117500), score: 0.57 TMEM135transmembrane protein 135 (ENSG00000166575), score: 0.59 TMEM20transmembrane protein 20 (ENSG00000176273), score: 0.74 TMEM33transmembrane protein 33 (ENSG00000109133), score: 0.55 TMEM55Atransmembrane protein 55A (ENSG00000155099), score: -0.67 TMEM82transmembrane protein 82 (ENSG00000162460), score: 0.5 TOM1L2target of myb1-like 2 (chicken) (ENSG00000175662), score: -0.58 TP53BP1tumor protein p53 binding protein 1 (ENSG00000067369), score: -0.74 TPST1tyrosylprotein sulfotransferase 1 (ENSG00000169902), score: 0.5 TRAF2TNF receptor-associated factor 2 (ENSG00000127191), score: 0.57 TRAM2translocation associated membrane protein 2 (ENSG00000065308), score: 0.61 TRAT1T cell receptor associated transmembrane adaptor 1 (ENSG00000163519), score: 0.5 TSKUtsukushi small leucine rich proteoglycan homolog (Xenopus laevis) (ENSG00000182704), score: 0.66 TTC21Btetratricopeptide repeat domain 21B (ENSG00000123607), score: -0.58 TTC36tetratricopeptide repeat domain 36 (ENSG00000172425), score: 0.6 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.82 TWISTNBTWIST neighbor (ENSG00000105849), score: 0.58 TWSG1twisted gastrulation homolog 1 (Drosophila) (ENSG00000128791), score: -0.77 TXNDC12thioredoxin domain containing 12 (endoplasmic reticulum) (ENSG00000117862), score: 0.52 UPB1ureidopropionase, beta (ENSG00000100024), score: 0.56 USO1USO1 vesicle docking protein homolog (yeast) (ENSG00000138768), score: 0.54 VSIG4V-set and immunoglobulin domain containing 4 (ENSG00000155659), score: 0.81 WDFY2WD repeat and FYVE domain containing 2 (ENSG00000139668), score: 0.71 XCR1chemokine (C motif) receptor 1 (ENSG00000173578), score: 0.76 XKR9XK, Kell blood group complex subunit-related family, member 9 (ENSG00000221947), score: 0.8 ZC3H12Dzinc finger CCCH-type containing 12D (ENSG00000178199), score: 0.68

Non-Entrez genes

ENSG00000143819Unknown, score: 0.68

Id	species	tissue	sex	individual
mml_lv_f_ca1	mml	lv	f	_
mml_lv_m_ca1	mml	lv	m	_
mdo_lv_f_ca1	mdo	lv	f	_
mdo_lv_m_ca1	mdo	lv	m	_
oan_lv_f_ca1	oan	lv	f	_
oan_lv_m_ca1	oan	lv	m	_