Genome Wide Association Studies

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# BaldingTutorial pmid=16983374
 
# BaldingTutorial pmid=16983374
 
# McCarthyReview pmid=18398418
 
# McCarthyReview pmid=18398418
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# FlintReview pmid=15803197
 
</biblio>
 
</biblio>

Revision as of 16:04, 5 February 2009

Some people in our group work on genome wide association studies (GWAS).

Introductory reading

For an introduction to GWAS, with an emphasis on human studies, you could start with a nice tutorial article [1], and a review of more recent issues [2]. There is also a nice review about approaches for rodent studies [3].

Statistical Methodology

Software

Many statistical methods are implemented in PLINK.

More sophisticated model based genotype imputation and association testing can be performed using IMPUTE and SNPTEST, or using MACH and ProbABEL.

Our own software for association testing using uncertain genotypes is QUICKTEST.

  1. Balding DJ. A tutorial on statistical methods for population association studies. Nat Rev Genet 2006 Oct; 7(10) 781-91. doi:10.1038/nrg1916 pmid:16983374. PubMed HubMed [BaldingTutorial]
  2. McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, and Hirschhorn JN. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008 May; 9(5) 356-69. doi:10.1038/nrg2344 pmid:18398418. PubMed HubMed [McCarthyReview]
  3. Flint J, Valdar W, Shifman S, and Mott R. Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet 2005 Apr; 6(4) 271-86. doi:10.1038/nrg1576 pmid:15803197. PubMed HubMed [FlintReview]
All Medline abstracts: PubMed HubMed