Robustness in Drosophila embryo patterning - Revision history

WikiSysop at 10:12, 21 August 2012

2012-08-21T10:12:06Z

WikiSysop: /* References */

2012-08-21T10:11:35Z

‎References

WikiSysop: /* References */

2012-08-21T10:11:21Z

‎References

WikiSysop: /* References */

2012-08-21T10:10:42Z

‎References

WikiSysop: /* References */

2012-08-21T10:10:26Z

‎References

WikiSysop: /* References */

2012-08-21T10:10:09Z

‎References

WikiSysop: /* References */

2012-08-21T10:09:53Z

‎References

WikiSysop: /* References */

2012-08-21T10:09:34Z

‎References

WikiSysop at 18:11, 23 February 2012

2012-02-23T18:11:01Z

Aitana: /* More info */

2011-02-24T15:42:36Z

‎More info

@@ Line 1: / Line 1: @@
 [[Category:Homepage]]
-Bicoid (Bcd) is a well studied morphogen involved in the patterning of the anterior-posterior (AP) axis of the Drosophila embryo <cite>drievera,drieverb</cite>. Zygotic downstream genes read out this gradient and their expression domains determine the basic body plan of the embryo along this axis. The positions of these domains are remarkably insensitive to fluctuations in the external environment <cite>houmandzadeh,lucchetta</cite> and their relative proportions are maintained across embryos of different sizes. The latter feature is referred to as scaling and occurs within a single species <cite>houmandzadeh,lott</cite> and also across different species <cite>gregor05,gregor08,lott</cite>.
+Bicoid (Bcd) is a well studied morphogen involved in the patterning of the anterior-posterior (AP) axis of the Drosophila embryo. Zygotic downstream genes read out this gradient and their expression domains determine the basic body plan of the embryo along this axis. The positions of these domains are remarkably insensitive to fluctuations in the external environment <cite>houmandzadeh,lucchetta</cite> and their relative proportions are maintained across embryos of different sizes. The latter feature is referred to as scaling and occurs within a single species <cite>houmandzadeh,lott</cite> and also across different species <cite>gregor05,gregor08,lott</cite>.
 Recent experiments also show that the Bicoid gradient itself is rather precise and that its length scale correlates to some extent to the embryo size <cite>gregor07a,he</cite>. These new findings suggest that the precision and scaling of Bcd target genes may, at least in part, be attributed to that of the morphogen gradient itself. Therefore, we investigate single morphogen models that aim at explaining the precision and scaling of Bcd target genes at the level of the morphogen gradient. However, it is likely that other mechanisms (e.g. Bcd interactions with the staufen gene <cite>aegerter05</cite>, gap genes interactions <cite>jaeger04</cite>, Bcd interactions with maternal Hunchback and the terminal system <cite>ochoa</cite> or bistability <cite>lopes</cite>) also contribute to ensure precise domain localization and further increase robustness in AP patterning.
@@ Line 23: / Line 23: @@
 == References ==
 <biblio>
 #ephrussi pmid=14744427
 #gregor05 pmid=16352710

@@ Line 23: / Line 23: @@
 == References ==
 <biblio>
-#drieverb pmid=3383245
+#drievera pmid=3383244

@@ Line 23: / Line 23: @@
 == References ==
 <biblio>
 #ephrussi pmid=14744427
 #gregor05 pmid=16352710
@@ Line 31: / Line 34: @@
 #lucchetta pmid=15858575
 #spirov pmid=19168676
 #lott pmid=17569783
 #gregor08 pmid=18328473
 #aegerter05 pmid=15721032
 #jaeger04 pmid=15254541
 #ochoa pmid=15793007
 #lopes pmid=18818726
 #houmandzadeh pmid=11845210
 </biblio>

← Older revision		Revision as of 10:10, 21 August 2012
Line 32:		Line 32:
	#spirov pmid=19168676		#spirov pmid=19168676

−	~~#drievera pmid=3383244~~
−	~~#drieverb pmid=3383245~~
	#lott pmid=17569783		#lott pmid=17569783
		+	#gregor08 pmid=18328473
		+	#aegerter05 pmid=15721032

← Older revision		Revision as of 10:10, 21 August 2012
Line 32:		Line 32:
	#spirov pmid=19168676		#spirov pmid=19168676

		+	#drievera pmid=3383244
		+	#drieverb pmid=3383245
		+	#lott pmid=17569783

← Older revision		Revision as of 10:09, 21 August 2012
Line 33:		Line 33:


		+	#drievera pmid=3383244
		+	#drieverb pmid=3383245
		+	#lott pmid=17569783
		+	#gregor08 pmid=18328473
		+	#aegerter05 pmid=15721032
	</biblio>		</biblio>

← Older revision		Revision as of 18:11, 23 February 2012
Line 1:		Line 1:
		+	[[Category:Homepage]]
		+
	Bicoid (Bcd) is a well studied morphogen involved in the patterning of the anterior-posterior (AP) axis of the Drosophila embryo <cite>drievera,drieverb</cite>. Zygotic downstream genes read out this gradient and their expression domains determine the basic body plan of the embryo along this axis. The positions of these domains are remarkably insensitive to fluctuations in the external environment <cite>houmandzadeh,lucchetta</cite> and their relative proportions are maintained across embryos of different sizes. The latter feature is referred to as scaling and occurs within a single species <cite>houmandzadeh,lott</cite> and also across different species <cite>gregor05,gregor08,lott</cite>.		Bicoid (Bcd) is a well studied morphogen involved in the patterning of the anterior-posterior (AP) axis of the Drosophila embryo <cite>drievera,drieverb</cite>. Zygotic downstream genes read out this gradient and their expression domains determine the basic body plan of the embryo along this axis. The positions of these domains are remarkably insensitive to fluctuations in the external environment <cite>houmandzadeh,lucchetta</cite> and their relative proportions are maintained across embryos of different sizes. The latter feature is referred to as scaling and occurs within a single species <cite>houmandzadeh,lott</cite> and also across different species <cite>gregor05,gregor08,lott</cite>.

@@ Line 10: / Line 10: @@
 == More info ==
-* [http://www.nature.com/msb/journal/v6/n1/pdf/msb20107.pdf Precision and Scaling in Morphogen gradient read-out] Aitana Morton de Lachapelle & Sven Bergmann
+* [http://www.nature.com/msb/journal/v6/n1/pdf/msb20107.pdf Precision and scaling in morphogen gradient read-out] Aitana Morton de Lachapelle & Sven Bergmann
 * [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010118/pdf/msb201086.pdf Pre-steady and stable morphogen gradients: can they coexist?] Aitana Morton de Lachapelle & Sven Bergmann
 * Introduction to Systems Biology, Uri Alon