Robustness in Drosophila embryo patterning

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Some people in the group investigate robustness in Drosophila early embryo A-P patterning.

Introductory reading

  • Introduction to Systems Biology, Uri Alon
  • Developmental Biology, Gilbert

Recommended reading

  • Review on A-P patterning in the Drosophila embryo [1][2]
  • Precision and Scaling of the Bicoid gradient [3][4][5][6][7][8]
  • Temperature robustness of the Bicoid gradient [9]


  1. Anterior-posterior patterning in the Drosophila embryo Advances in Developmental Biology and Biochemistry, 2002, 12, 155-204 [nasiadka]
  2. Ephrussi A and St Johnston D. Seeing is believing: the bicoid morphogen gradient matures. Cell 2004 Jan 23; 116(2) 143-52. pmid:14744427. PubMed HubMed [ephrussi]
  3. Gregor T, Bialek W, de Ruyter van Steveninck RR, Tank DW, and Wieschaus EF. Diffusion and scaling during early embryonic pattern formation. Proc Natl Acad Sci U S A 2005 Dec 20; 102(51) 18403-7. doi:10.1073/pnas.0509483102 pmid:16352710. PubMed HubMed [gregor05]
  4. Bergmann S, Sandler O, Sberro H, Shnider S, Schejter E, Shilo BZ, and Barkai N. Pre-steady-state decoding of the Bicoid morphogen gradient. PLoS Biol 2007 Feb; 5(2) e46. doi:10.1371/journal.pbio.0050046 pmid:17298180. PubMed HubMed [bergmann]
  5. Gregor T, Wieschaus EF, McGregor AP, Bialek W, and Tank DW. Stability and nuclear dynamics of the bicoid morphogen gradient. Cell 2007 Jul 13; 130(1) 141-52. doi:10.1016/j.cell.2007.05.026 pmid:17632061. PubMed HubMed [gregor07a]
  6. Gregor T, Tank DW, Wieschaus EF, and Bialek W. Probing the limits to positional information. Cell 2007 Jul 13; 130(1) 153-64. doi:10.1016/j.cell.2007.05.025 pmid:17632062. PubMed HubMed [gregor07]
  7. He F, Wen Y, Deng J, Lin X, Lu LJ, Jiao R, and Ma J. Probing intrinsic properties of a robust morphogen gradient in Drosophila. Dev Cell 2008 Oct; 15(4) 558-67. doi:10.1016/j.devcel.2008.09.004 pmid:18854140. PubMed HubMed [he]
  8. Lucchetta EM, Lee JH, Fu LA, Patel NH, and Ismagilov RF. Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics. Nature 2005 Apr 28; 434(7037) 1134-8. doi:10.1038/nature03509 pmid:15858575. PubMed HubMed [lucchetta]
  9. Houchmandzadeh B, Wieschaus E, and Leibler S. Establishment of developmental precision and proportions in the early Drosophila embryo. Nature 2002 Feb 14; 415(6873) 798-802. doi:10.1038/415798a pmid:11845210. PubMed HubMed [houmandzadeh]
All Medline abstracts: PubMed HubMed