Science - Revision history

WikiSysop: /* Study of small genetic networks */

2012-08-21T10:30:41Z

‎Study of small genetic networks

Sven: /* Developmental Patterning */

2011-06-15T08:16:17Z

‎Developmental Patterning

Sven: /* Light response */

2011-06-15T08:13:24Z

‎Light response

Sven: /* Light response */

2011-06-15T08:10:41Z

‎Light response

Sven: /* Light response */

2011-06-15T08:10:00Z

‎Light response

Sven: /* Developmental Patterning */

2011-06-15T08:08:24Z

‎Developmental Patterning

Sven: /* Developmental Patterning */

2011-06-15T08:07:02Z

‎Developmental Patterning

Sven: /* Study of small genetic networks */

2011-05-23T19:35:18Z

‎Study of small genetic networks

Sven: /* The need for reduction of complexity */

2011-05-23T19:32:43Z

‎The need for reduction of complexity

Sven: /* The need for reduction of complexity */

2011-05-23T19:32:09Z

‎The need for reduction of complexity

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 == Study of small genetic networks ==
-A complementary direction of research pertains to relatively small genetic networks, whose components are well-known. Our research is focused on such networks in two different organisms: In the fruitfly we study the systems responsible for patternming along the anterior-posterioaxis in the early embryo development (goverened by the morphogen Bicoid, see [[Robustness in Drosophila embryo patterning]] for details) and for structuring the precursor of the wing (know as the imaginal wing disk, see [[WingX: Systems Biology of the Drosophila Wing]]). We are also interested in [[Phototropism in Arabidopsis|phototropism in plants]] based on the model organism ''Arabidopsis thaliana'', which is a small flowering plant known otherwise as "thale cress".
+A complementary direction of research pertains to relatively small genetic networks, whose components are well-known. Our research is focused on such networks in two different organisms: In the fruitfly we study the systems responsible for patternming along the anterior-posterioaxis in the early embryo development (goverened by the morphogen Bicoid, see [[Robustness in Drosophila embryo patterning]] for details) and for structuring the precursor of the wing (know as the imaginal wing disk). We are also interested in [[Phototropism in Arabidopsis|phototropism in plants]] based on the model organism ''Arabidopsis thaliana'', which is a small flowering plant known otherwise as "thale cress".
 === Developmental Patterning ===

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 === Developmental Patterning ===
-We are intrigued by the fundamental question of how a developing tissue can tell head from tail. In other words: how do indiviudal cell "know" their respective differentiation program? One solution nature has come up with to read out positional information is to use graded profiles of so-called "morphogens". Within the SystemsX.ch project [http://www.systemsx.ch/index.php?id=149 WingX] we study how the morphogen gradients are formed and how the information is processed to give rise to robust patterning.
+We are intrigued by the fundamental question of how a developing tissue can tell head from tail. In other words: how do indiviudal cell "know" their respective differentiation program? One solution nature has come up with to read out positional information is to use graded profiles of so-called "morphogens". Within the SystemsX.ch project [http://www.systemsx.ch/index.php?id=149 WingX] together with the [http://www.biozentrum.unibas.ch/affolter/index.html Affolter] and  [http://www.imls.uzh.ch/research/basler.html Basler] labs we study how the morphogen gradients are formed and how the information is processed to give rise to robust patterning.
 === Light response ===
 Plants need light for their basic metabolism. Sunflowers literally follow the sun, but even little seedlings already bend their first leaves towards the light to maximize their energy intake. When in competition for light with other plants one can observe that many plants become much taller than when they grow alone. Within the SystemsX.ch project on [http://www.systemsx.ch/projects/systemsxch-projects/research-technology-and-development-projects-rtd/plant-growth/ Plant Growth] we collaborate with the [http://www.unil.ch/cig/page8391.html Fankhauser lab] with the aim to unravel the molecular mechanisms that give rise to these fascinating phenomena.

← Older revision		Revision as of 08:13, 15 June 2011
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	=== Light response ===		=== Light response ===

−	Plants need light for their basic metabolism. Sunflowers literally follow the sun, but even little seedlings already bend their first leaves towards the light to maximize their energy intake. When in competition for light with other plants one can observe that many plants become much taller than when they grow alone. ~~We participate in~~ the SystemsX.ch project on [http://www.systemsx.ch/projects/systemsxch-projects/research-technology-and-development-projects-rtd/plant-growth/ Plant Growth] to ~~help unraveling~~ the molecular mechanisms that give rise to these fascinating phenomena.	+	Plants need light for their basic metabolism. Sunflowers literally follow the sun, but even little seedlings already bend their first leaves towards the light to maximize their energy intake. When in competition for light with other plants one can observe that many plants become much taller than when they grow alone. Within the SystemsX.ch project on [http://www.systemsx.ch/projects/systemsxch-projects/research-technology-and-development-projects-rtd/plant-growth/ Plant Growth] we collaborate with the [http://www.unil.ch/cig/page8391.html Fankhauser lab] with the aim to unravel the molecular mechanisms that give rise to these fascinating phenomena.

← Older revision		Revision as of 08:10, 15 June 2011
Line 50:		Line 50:
	=== Light response ===		=== Light response ===

−	Plants need light for their basic metabolism. Sunflowers literally follow the sun, but even little seedlings already bend their first leaves towards the light to maximize their energy intake. When in competition for light with other plants one can observe that many plants become much taller than when they grow alone. We participate in the SystemsX.ch project on [~~Plant Growth~~ http://www.systemsx.ch/projects/systemsxch-projects/research-technology-and-development-projects-rtd/plant-growth/] to help unraveling the molecular mechanisms that give rise to these fascinating phenomena.	+	Plants need light for their basic metabolism. Sunflowers literally follow the sun, but even little seedlings already bend their first leaves towards the light to maximize their energy intake. When in competition for light with other plants one can observe that many plants become much taller than when they grow alone. We participate in the SystemsX.ch project on [http://www.systemsx.ch/projects/systemsxch-projects/research-technology-and-development-projects-rtd/plant-growth/ Plant Growth] to help unraveling the molecular mechanisms that give rise to these fascinating phenomena.

← Older revision		Revision as of 08:10, 15 June 2011
Line 50:		Line 50:
	=== Light response ===		=== Light response ===

−	Plants need light for their basic metabolism. Sunflowers literally follow the sun, but even little seedlings already bend their first leaves towards the light to maximize their energy intake. When in competition for light with other plants one can observe that many plants become much taller than when they grow alone. We participate in the SystemsX.ch project ~~PlantX~~ to help unraveling the molecular mechanisms that give rise to these fascinating phenomena.	+	Plants need light for their basic metabolism. Sunflowers literally follow the sun, but even little seedlings already bend their first leaves towards the light to maximize their energy intake. When in competition for light with other plants one can observe that many plants become much taller than when they grow alone. We participate in the SystemsX.ch project on [Plant Growth http://www.systemsx.ch/projects/systemsxch-projects/research-technology-and-development-projects-rtd/plant-growth/] to help unraveling the molecular mechanisms that give rise to these fascinating phenomena.

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 .	It reduces the noise in the data, since fluctuations in the individual (redundant) variables tend to cancel each other out.
-.	It may provide biological focus if the individual elements share common features (e.g. genes belonging to the same metabolic pathway)
+.	It may provide biological focus if the individual elements share common features (e.g. genes belonging to the same metabolic pathway).
-.	It may provide insights into the structure of the underlying regulatory network (e.g. groups of gene being organized in a hierarchical manner)
+.	It may provide insights into the structure of the underlying regulatory network (e.g. groups of gene being organized in a hierarchical manner).
 These advantages have been well-recognized for large-scale gene-expression data and a multitude of methods has been developed to identify groups (or “modules”) from such data.

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 === The need for reduction of complexity ===
 Molecular phenotypes, like transcript and metabolite concentrations, provide much more immediate information on the impact of genotypic variation than the resulting organismal phenotypes. Yet, in general the number of molecular observables (e.g. the number of genes or metabolites) is much larger. Moreover, their measurements are often noisy. Thus assigning genes or metabolites into groups and considering the group average has the following advantages:
 .	It reduces the complexity of such data, since the number of groups is typically much smaller than the number of individual elements.
 .	It reduces the noise in the data, since fluctuations in the individual (redundant) variables tend to cancel each other out.
 .	It may provide biological focus if the individual elements share common features (e.g. genes belonging to the same metabolic pathway)
 .	It may provide insights into the structure of the underlying regulatory network (e.g. groups of gene being organized in a hierarchical manner)