ExpressionView data file 1.1 eisa 82 3522 128

Chiaretti et al. Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Gene expression profiles were examined in 33 adult patients with T-cell acute lymphocytic leukemia (T-ALL). Nonspecific filtering criteria identified 313 genes differentially expressed in the leukemic cells. Hierarchical clustering of samples identified 2 groups that reflected the degree of T-cell differentiation but was not associated with clinical outcome. Comparison between refractory patients and those who responded to induction chemotherapy identified a single gene, interleukin 8 (IL-8), that was highly expressed in refractory T-ALL cells and a set of 30 genes that was highly expressed in leukemic cells from patients who achieved complete remission. We next identified 19 genes that were differentially expressed in T-ALL cells from patients who either had a relapse or remained in continuous complete remission. A model based on the expression of 3 of these genes was predictive of duration of remission. The 3-gene model was validated on a further set of T-ALL samples from 18 additional patients treated on the same clinical protocol. This study demonstrates that gene expression profiling can identify a limited number of genes that are predictive of response to induction therapy and remission duration in adult patients with T-ALL. hgu95av2 Homo sapiens # Name Symbol EntrezID 1 38526_at PDE4D 5144 2 31731_at CBX4 8535 3 1826_at RHOB 388 4 31623_f_at MT1A 4489 5 609_f_at MT1B 4490 6 36130_f_at MT1E 4493 7 31622_f_at MT1F 4494 8 39594_f_at MT1H 4496 9 926_at MT1G 4495 10 39120_at MT1X 4501 11 1473_s_at MYB 4602 12 351_f_at SFRS3 6428 13 38894_g_at NCF4 4689 14 37902_at CRYZ 1429 15 318_at H1FX 8971 16 33500_i_at NA NA 17 37864_s_at NA NA 18 33499_s_at NA NA 19 38194_s_at NA NA 20 33274_f_at IGL@ 3535 21 38276_at NFKBIE 4794 22 34759_at SLC30A1 7779 23 37037_at P4HA1 5033 24 37445_at TMEM5 10329 25 36654_s_at HNRNPA2B1 3181 26 36898_r_at PRIM2 5558 27 623_s_at RAB2A 5862 28 35972_at RNASEH2B 79621 29 31860_at TMEM11 8834 30 425_at IFI27 3429 31 40505_at UBE2L6 9246 32 38251_at MYL6B 140465 33 31690_at GLUD2 2747 34 36482_s_at ATP2A3 489 35 40864_at RAC1 5879 36 1318_at RBBP4 5928 37 41466_s_at ZNF148 7707 38 429_f_at TUBB4 10382 39 39226_at CD3G 917 40 32794_g_at NA NA 41 40688_at NA NA 42 33238_at LCK 3932 43 38319_at CD3D 915 44 39296_at LOC150759 150759 45 36194_at LRPAP1 4043 46 33674_at RPL29 6159 47 37360_at LY6E 4061 48 36941_at MLLT11 10962 49 38051_at MAL 4118 50 39814_s_at DHRS7 51635 51 39753_at ITGA5 3678 52 2049_s_at JUNB 3726 53 35620_at TOMM40 10452 54 31927_s_at NA NA 55 35800_at PAFAH1B3 5050 56 976_s_at MAPK1 5594 57 36027_at POLR2F 5435 58 33393_at DDX19B 11269 59 39347_at AP2S1 1175 60 410_s_at CSNK2B 1460 61 2025_s_at APEX1 328 62 1161_at HSP90AB1 3326 63 31638_at NDUFS7 374291 64 2016_s_at RPL10 6134 65 34358_at MRPL23 6150 66 37911_at STX4 6810 67 41475_at NINJ1 4814 68 1553_r_at CYP2A13 1553 69 38613_at ZNHIT1 10467 70 AFFX-HUMGAPDH/M33197_5_at GAPDH 2597 71 34302_at EIF3G 8666 72 35773_i_at NDUFB7 4713 73 37329_at NDUFV1 4723 74 1764_s_at MAZ 4150 75 1493_r_at NA NA 76 32146_s_at ADD1 118 77 31608_g_at VDAC1 7416 78 1751_g_at FARSA 2193 79 32737_at RAC2 5880 80 34947_at APOBEC3G 60489 81 1268_at UBA1 7317 82 626_s_at IFI35 3430 83 653_at RFC5 5985 84 37557_at SLC4A2 6522 85 35807_at CYBA 1535 86 AFFX-HSAC07/X00351_5_at ACTB 60 87 1984_s_at ARHGDIB 397 88 38476_at RBM15B 29890 89 1333_f_at BCR 613 90 40495_at ORAI2 80228 91 33628_g_at PIK3CD 5293 92 481_at SNRK 54861 93 32004_s_at NA NA 94 32523_at CLTB 1212 95 1752_at CALR 811 96 39523_at STX16 8675 97 36158_at DCTN1 1639 98 33650_at DDX27 55661 99 1565_s_at GRB2 2885 100 34279_at NA NA 101 34691_f_at ARPC4 10093 102 39076_s_at DRAP1 10589 103 39280_at CNPY3 10695 104 31364_i_at NFAT5 10725 105 446_at CSNK1G2 1455 106 41337_at AES 166 107 922_at PPP2R1A 5518 108 33989_f_at TMBIM6 7009 109 369_s_at UBE2H 7328 110 39112_at USF2 7392 111 36530_g_at TRAPPC6A 79090 112 1615_at BCL2L1 598 113 40514_at ERGIC3 51614 114 146_at PI4KB 5298 115 37376_at UBXN1 51035 116 39711_at PRKCSH 5589 117 41181_r_at DDT 1652 118 40439_at ASNA1 439 119 36936_at TSTA3 7264 120 41565_at ATXN2L 11273 121 40081_at PLTP 5360 122 34510_at CDT1 81620 123 1998_i_at BAX 581 124 175_s_at PKN1 5585 125 754_s_at BCR 613 126 160026_at PRKX 5613 127 39540_at ZBTB7A 51341 128 580_at HIST1H1E 3008 129 38022_s_at PLEC 5339 130 32844_at EIF4G1 1981 131 36586_at AIP 9049 132 1397_at MAP3K11 4296 133 1861_at BAD 572 134 37768_at MPG 4350 135 544_at NFKB2 4791 136 33382_at NAAA 27163 137 40773_at MYL5 4636 138 40152_r_at PEX5 5830 139 36528_at ASL 435 140 1597_at GAS6 2621 141 1274_s_at CDC34 997 142 37925_r_at APOM 55937 143 32041_r_at CDC5L 988 144 40282_s_at CFD 1675 145 220_r_at MAP2 4133 146 38414_at CDC20 991 147 37044_at PDIA5 10954 148 40472_at LPCAT4 254531 149 40562_at GNA11 2767 150 981_at MCM4 4173 151 35975_at MLLT3 4300 152 39324_at PGAP1 80055 153 32720_at ATG12 9140 154 893_at UBE2S 27338 155 1976_s_at FES 2242 156 1753_s_at RAD23A 5886 157 423_at EWSR1 2130 158 33414_at NA NA 159 37637_at RGS3 5998 160 1902_at ERCC1 2067 161 39893_at GNG7 2788 162 187_at MAP4K2 5871 163 41325_at KCNK3 3777 164 37086_at LYZL6 57151 165 31597_r_at EIF4EBP1 1978 166 37546_r_at SCAMP5 192683 167 41850_s_at CCDC85B 11007 168 39154_at GADD45G 10912 169 34270_at LSM5 23658 170 34181_at AGA 175 171 499_at MAD1L1 8379 172 399_at STK25 10494 173 37474_at OIP5 11339 174 32067_at CREM 1390 175 31605_at LOC171220 171220 176 40409_at ALDH3A2 224 177 876_at GNAI3 2773 178 38279_at GNAZ 2781 179 41198_at GRN 2896 180 349_g_at KIFC1 3833 181 39381_at C6orf120 387263 182 982_at MCM5 4174 183 34175_r_at LOC440248 440248 184 39089_at NME4 4833 185 38511_at ZNF529 57711 186 33265_at PEX2 5828 187 1919_at VAV1 7409 188 33124_at VRK2 7444 189 39727_at DUSP11 8446 190 101_at DYRK4 8798 191 35545_at SLC4A8 9498 192 39776_at ULK2 9706 193 41838_at HAUS7 55559 194 448_s_at MEN1 4221 195 36044_at PDE6D 5147 196 39537_at KLHDC3 116138 197 40169_at PLIN3 10226 198 34417_at DPY19L2P2 349152 199 40673_at ACADSB 36 200 36753_at LILRB4 11006 201 965_at MARK2 2011 202 40933_f_at ZDHHC18 84243 203 114_r_at MAPT 4137 204 36775_f_at PRB1 5542 205 32620_at FETUB 26998 206 34074_s_at GNAT1 2779 207 1574_s_at IL4 3565 208 38915_at NA NA 209 35670_at ATP1A3 478 210 39480_s_at SCAPER 49855 211 35950_at NA NA 212 33673_r_at UGT2B17 7367 213 37793_r_at RAD51L3 5892 214 1755_i_at CYP3A4 1576 215 38825_at FGA 2243 216 33555_at LILRA4 23547 217 31497_at NA NA 218 613_at KRT5 3852 219 34266_at LEPR 3953 220 39361_f_at TSPAN6 7105 221 34058_at NA NA 222 36850_at TUSC3 7991 223 37396_at RFXANK 8625 224 39953_i_at ZNF623 9831 225 34527_r_at LOC157627 157627 226 36699_at DSCAM 1826 227 36410_f_at ELAVL2 1993 228 1526_i_at FGF8 2253 229 33359_at LPHN3 23284 230 40094_r_at BCAM 4059 231 37368_at NFATC4 4776 232 33383_f_at SFTPB 6439 233 33052_at PLA2G10 8399 234 32274_r_at XRCC6 2547 235 36450_at PYY 5697 236 31642_at RASAL2 9462 237 35089_at NRG2 9542 238 34702_f_at psiTPTE22 387590 239 36020_at NA NA 240 40528_at LHX2 9355 241 32036_i_at RPP14 11102 242 34367_at PHGDH 26227 243 2004_at MAP3K1 4214 244 471_f_at TUBB3 10381 245 37467_at IGHD 3495 246 37377_i_at LMNA 4000 247 1854_at MYBL2 4605 248 36312_at SERPINB8 5271 249 37617_at FAM190B 54462 250 37479_at CD72 971 251 33598_r_at NLRP3 114548 252 2031_s_at CDKN1A 1026 253 33705_at PDE4B 5142 254 41462_at SNX2 6643 255 36053_at CDKN2C 1031 256 38567_at CD1D 912 257 40699_at CD8A 925 258 40949_at DYNC1LI2 1783 259 1097_s_at CCR7 1236 260 1797_at CDKN2D 1032 261 40404_s_at CDC16 8881 262 38984_at PREPL 9581 263 34801_at PAN2 9924 264 35818_at CYCS 54205 265 41058_g_at ACOT13 55856 266 32765_f_at PGCP 10404 267 37185_at SERPINB2 5055 268 40421_at PIN1 5300 269 189_s_at PLAUR 5329 270 1718_at ARPC2 10109 271 33817_at NA NA 272 37105_at CTSG 1511 273 32668_at SSBP2 23635 274 36280_at GZMK 3003 275 31684_at ANXA2P1 303 276 2045_s_at HCK 3055 277 1456_s_at IFI16 3428 278 38533_s_at ITGAM 3684 279 37918_at ITGB2 3689 280 35449_at KLRB1 3820 281 963_at LIG4 3981 282 33255_at NASP 4678 283 41038_at NCF2 4688 284 37121_at NKG7 4818 285 39997_at CFP 5199 286 37326_at PLP2 5355 287 32227_at SRGN 5552 288 2002_s_at BCL2A1 597 289 33348_at TCF12 6938 290 1693_s_at TIMP1 7076 291 37351_at UPP1 7378 292 37027_at AHNAK 79026 293 31506_s_at NA NA 294 37747_at ANXA5 308 295 37603_at IL1RN 3557 296 1062_g_at IL10RA 3587 297 38323_at CPVL 54504 298 35224_at C17orf91 84981 299 33925_at NRGN 4900 300 1115_at PF4 5196 301 37021_at CTSH 1512 302 1365_at IL2RB 3560 303 35012_at MNDA 4332 304 1403_s_at CCL5 6352 305 39728_at IFI30 10437 306 35926_s_at NA NA 307 37148_at NA NA 308 38111_at VCAN 1462 309 39581_at CSTA 1475 310 36889_at FCER1G 2207 311 36447_at FCN1 2219 312 36709_at ITGAX 3687 313 41096_at S100A8 6279 314 41471_at S100A9 6280 315 39545_at CDKN1C 1028 316 37145_at GNLY 10578 317 39593_at FGL2 10875 318 33232_at CRIP1 1396 319 37200_at NA NA 320 34714_at SAMHD1 25939 321 32370_at GZMH 2999 322 37137_at GZMB 3002 323 37403_at ANXA1 301 324 769_s_at NA NA 325 31444_s_at NA NA 326 33412_at LGALS1 3956 327 35132_at MYO1F 4542 328 38087_s_at S100A4 6275 329 39338_at S100A10 6281 330 38138_at S100A11 6282 331 32806_at TSPO 706 332 34965_at CST7 8530 333 38006_at CD48 962 334 38326_at G0S2 50486 335 36766_at RNASE2 6036 336 36781_at SERPINA1 5265 337 38363_at TYROBP 7305 338 39208_i_at PPBP 5473 339 40769_r_at NUP214 8021 340 35367_at LGALS3 3958 341 31687_f_at HBB 3043 342 31525_s_at NA NA 343 39729_at PRDX2 7001 344 35785_at GABARAPL1 23710 345 33932_at GSPT1 2935 346 40260_g_at RBM9 23543 347 37650_at MKRN1 23608 348 35337_at FBXO7 25793 349 38990_at FBXO9 26268 350 35767_at GABARAPL2 11345 351 33796_at ARL4A 10124 352 38354_at CEBPB 1051 353 34740_at FOXO3 2309 354 35083_at FTL 2512 355 1717_s_at BIRC3 330 356 35372_r_at IL8 3576 357 39331_at TUBB2A 7280 358 34760_at CD302 9936 359 32747_at ALDH2 217 360 35310_at PIP4K2A 5305 361 32153_s_at UBB 7314 362 31888_s_at PHLDA2 7262 363 37179_at NFE2 4778 364 36636_at OAT 4942 365 40419_at STOM 2040 366 38714_at NA NA 367 32663_at RHAG 6005 368 31931_f_at RHCE 6006 369 40064_at TRAK2 66008 370 36792_at TPM1 7168 371 40095_at CA2 760 372 40990_at TSPAN5 10098 373 37285_at ALAS2 212 374 38715_at GYPB 2994 375 41024_f_at GYPE 2996 376 33516_at HBD 3045 377 38585_at NA NA 378 37649_at HMBS 3145 379 33336_at SLC4A1 6521 380 36036_at SPTB 6710 381 40647_at XK 7504 382 39174_at NCOA4 8031 383 36871_at EPB42 2038 384 37192_at EPB49 2039 385 36713_at TRIM58 25893 386 40062_s_at MYL4 4635 387 37002_at BLVRB 645 388 39436_at BNIP3L 665 389 33759_at BPGM 669 390 36162_at BSG 682 391 37405_at SELENBP1 8991 392 39072_at MXI1 4601 393 40848_g_at MICAL2 9645 394 37999_at CPOX 1371 395 38325_at MINPP1 9562 396 1564_at AKT1 207 397 39795_at AP2M1 1173 398 36526_at EXTL2 2135 399 39236_s_at FAAH 2166 400 36511_at SACM1L 22908 401 33219_at USP33 23032 402 37028_at PPP1R15A 23645 403 39122_at GPI 2821 404 40952_at NA NA 405 40490_at DDX21 9188 406 33901_at SLC29A1 2030 407 38104_at DECR1 1666 408 39243_s_at PSIP1 11168 409 38368_at DUT 1854 410 35741_at PIP4K2B 8396 411 32961_at DENND4A 10260 412 36978_at PSME4 23198 413 1039_s_at HIF1A 3091 414 32676_at ALDH6A1 4329 415 41690_at ARID5B 84159 416 35169_at COL16A1 1307 417 34723_at COX11 1353 418 39077_at NCRNA00188 125144 419 32843_s_at FBL 2091 420 40951_at NA NA 421 36971_at TMEM131 23505 422 466_at NA NA 423 41484_r_at JUND 3727 424 35341_at TRIM38 10475 425 32562_at ENG 2022 426 32542_at FHL1 2273 427 36908_at NA NA 428 39134_at TOM1 10043 429 39299_at FASTKD2 22868 430 32336_at ALDOA 226 431 39224_at ARAP2 116984 432 37352_at SP100 6672 433 32835_at RIOK3 8780 434 36336_s_at SBNO2 22904 435 36125_s_at RALY 22913 436 374_f_at NA NA 437 36234_at EIF4A1 1973 438 38880_at MAPKBP1 23005 439 32636_f_at SMG1 23049 440 40278_at GGA2 23062 441 33943_at FTH1 2495 442 33439_at SIK1 150094 443 39428_at SH2B3 10019 444 1139_at GNA13 10672 445 38037_at HBEGF 1839 446 931_at GPR183 1880 447 35851_g_at JMJD6 23210 448 36669_at FOSB 2354 449 32901_s_at IFRD1 3475 450 39822_s_at GADD45B 4616 451 287_at ATF3 467 452 37623_at NR4A2 4929 453 39827_at DDIT4 54541 454 39185_at WDR45L 56270 455 36979_at SLC2A3 6515 456 40448_at ZFP36 7538 457 36913_at SLBP 7884 458 190_at NR4A3 8013 459 35000_at TNFSF9 8744 460 1924_at CCNH 902 461 38031_at EIF4A3 9775 462 34333_at JOSD1 9929 463 38664_at CFDP1 10428 464 40570_at FOXO1 2308 465 39615_at RP1-21O18.1 23254 466 35321_at TLK2 11011 467 41635_at WTAP 9589 468 41829_at LARP1 23367 469 40171_at FRAT2 23401 470 382_at PPP4C 5531 471 41540_at PPP1R7 5510 472 36827_at ACBD3 64746 473 283_at UQCRC1 7384 474 41397_at ZNF821 55565 475 798_at PRIM1 5557 476 786_at POLA1 5422 477 527_at CENPA 1058 478 37302_at CENPF 1063 479 151_s_at TUBB 203068 480 33429_at C18orf10 25941 481 32791_at TMEM97 27346 482 33252_at MCM3 4172 483 40145_at TOP2A 7153 484 34216_at KLF7 8609 485 1945_at CCNB1 891 486 41626_at TIMELESS 8914 487 40412_at PTTG1 9232 488 37231_at DLGAP5 9787 489 39677_at GINS1 9837 490 1599_at CDKN3 1033 491 1721_g_at MAD2L1 4085 492 37739_at SSRP1 6749 493 33346_r_at TUBG1 7283 494 32589_at CHAF1A 10036 495 975_at PLK4 10733 496 36837_at KIF2C 11004 497 1651_at UBE2C 11065 498 35995_at ZWINT 11130 499 41583_at FEN1 2237 500 39109_at TPX2 22974 501 34715_at FOXM1 2305 502 40726_at KIF11 3832 503 35312_at MCM2 4171 504 40117_at MCM6 4175 505 947_at MCM7 4176 506 419_at MKI67 4288 507 1884_s_at PCNA 5111 508 34314_at RRM1 6240 509 35699_at BUB1B 701 510 1505_at TYMS 7298 511 37458_at CDC45L 8318 512 32263_at CCNB2 9133 513 38158_at ESPL1 9700 514 38116_at KIAA0101 9768 515 1803_at CDK1 983 516 38847_at MELK 9833 517 34563_at KIF14 9928 518 1185_at IL3RA 3563 519 34332_at GNPDA1 10007 520 39020_at SIVA1 10572 521 34780_at PLXNB2 23654 522 33809_at GNAI1 2770 523 37033_s_at GPX1 2876 524 37383_f_at NA NA 525 34934_at HCG26 352961 526 41172_at RDH11 51109 527 35839_at SQLE 6713 528 33514_at CAMK4 814 529 38994_at SOCS2 8835 530 36277_at CD3E 916 531 1792_g_at CDK2 1017 532 39345_at NPC2 10577 533 38802_at PGRMC1 10857 534 41796_at PLCL2 23228 535 41569_at DNAJC9 23234 536 33924_at DENND5A 23258 537 356_at KIF22 3835 538 37710_at MEF2C 4208 539 860_at MSH2 4436 540 36489_at PRPS1 5631 541 1055_g_at RFC4 5984 542 34383_at USP1 7398 543 38988_at WHSC1 7468 544 1809_at CDC7 8317 545 39724_s_at CUL1 8454 546 40738_at CD2 914 547 35162_s_at ACVR2A 92 548 38378_at CD53 963 549 35625_at CD97 976 550 40698_at CLEC2B 9976 551 33291_at RASGRP1 10125 552 39865_at KCTD7 154881 553 41225_at DUSP3 1845 554 37615_at GRB10 2887 555 32184_at LMO2 4005 556 903_at PPP2R5A 5525 557 39756_g_at XBP1 7494 558 36545_s_at SFI1 9814 559 32253_at RERE 473 560 36473_at USP20 10868 561 41819_at FYB 2533 562 32035_at NA NA 563 39248_at AQP3 360 564 2047_s_at JUP 3728 565 33121_g_at RGS10 6001 566 41164_at IGHM 3507 567 39829_at ARL4C 10123 568 40147_at VAT1 10493 569 39930_at EPHB6 2051 570 38147_at SH2D1A 4068 571 34403_at MFGE8 4240 572 33039_at TRAT1 50852 573 633_s_at TFDP2 7029 574 36243_at TLR1 7096 575 1498_at ZAP70 7535 576 39839_at CSDA 8531 577 37539_at RGL1 23179 578 34033_s_at LILRA2 11027 579 35719_at PHLPP1 23239 580 37420_i_at HLA-F 3134 581 35643_at NUCB2 4925 582 36117_at PTK2 5747 583 31891_at CHI3L2 1117 584 36638_at CTGF 1490 585 41155_at CTNNA1 1495 586 35842_at IL6ST 3572 587 39318_at TCL1A 8115 588 37988_at CD79B 974 589 907_at ADA 100 590 41348_at IRX5 10265 591 133_at CTSC 1075 592 40953_at CNN3 1266 593 40745_at AP1B1 162 594 41651_at KIAA1033 23325 595 40522_at GLUL 2752 596 32595_at GRSF1 2926 597 37497_at HHEX 3087 598 32773_at HLA-DQA1 3117 599 39328_at HMGCR 3156 600 172_at INPP5D 3635 601 33839_at ITPR2 3709 602 33819_at LDHB 3945 603 1857_at SMAD7 4092 604 40584_at NUP88 4927 605 41710_at PION 54103 606 38805_at TGIF1 7050 607 41489_at TLE1 7088 608 36591_at TUBA4A 7277 609 36102_at VDAC3 7419 610 316_g_at PRDM2 7799 611 39628_at RAB9A 9367 612 40775_at ITM2A 9452 613 33316_at TOX 9760 614 38385_at DSTN 11034 615 39781_at IGFBP4 3487 616 32612_at GSN 2934 617 41723_s_at NA NA 618 38949_at PRKCQ 5588 619 1096_g_at CD19 930 620 39631_at EMP2 2013 621 39400_at TBC1D2B 23102 622 38314_at CIC 23152 623 36970_at KIAA0182 23199 624 36808_at PTPN22 26191 625 40511_at GATA3 2625 626 31763_at OR7A5 26659 627 1478_at ITK 3702 628 36502_at CDK14 5218 629 1463_at PTPN12 5782 630 40210_at RAB13 5872 631 33369_at SC4MOL 6307 632 40069_at SVIL 6840 633 40075_at SYT1 6857 634 946_at DYNLT1 6993 635 32706_at HIRA 7290 636 36643_at DDR1 780 637 36732_at ABCC10 89845 638 37844_at IL27RA 9466 639 40417_at CCT5 22948 640 40774_at CCT3 7203 641 41526_at HMG20B 10362 642 37533_r_at TTC9 23508 643 34998_at PRMT3 10196 644 776_at PIGF 5281 645 40615_at SPG11 80208 646 40349_at CBR4 84869 647 38621_at DDAH2 23564 648 38640_at ZNF593 51042 649 33591_at NA NA 650 37729_at XPO1 7514 651 33659_at CFL1 1072 652 1638_at ETV6 2120 653 40877_s_at NA NA 654 33742_f_at ATP6V1H 51606 655 1817_at PFDN5 5204 656 35933_f_at PMS2L3 5387 657 33131_at SOX4 6659 658 33641_g_at AIF1 199 659 829_s_at GSTP1 2950 660 37411_at ACAP1 9744 661 34234_f_at NKTR 4820 662 36209_at BRD2 6046 663 39184_at TCEB2 6923 664 35439_at SF1 7536 665 38750_at NOTCH3 4854 666 36874_at CR2 1380 667 32813_s_at KATNB1 10300 668 33214_at MRPS12 6183 669 34749_at SLC31A2 1318 670 370_at STK38 11329 671 239_at CTSD 1509 672 35763_at NBEAL2 23218 673 38310_at CNOT3 4849 674 160044_g_at ACO2 50 675 40955_at PTOV1 53635 676 39749_at PSMD4 5710 677 33818_at VCP 7415 678 1550_at MRPL28 10573 679 37040_at GANAB 23193 680 41273_at MXRA7 439921 681 41498_at CLSTN1 22883 682 36458_at MTMR15 22909 683 34712_at DNMBP 23268 684 41430_at WDR7 23335 685 36610_at R3HDM1 23518 686 31697_s_at NA NA 687 1589_s_at NA NA 688 404_at IL4R 3566 689 359_at IL13RA1 3597 690 39258_at RNF126 55658 691 39253_s_at RALA 5898 692 41741_at RBM3 5935 693 34849_at SARS 6301 694 1226_at ADAM17 6868 695 1375_s_at TIMP2 7077 696 34160_at ACTG1 71 697 37431_at PIAS2 9063 698 1269_at PIK3R1 5295 699 2036_s_at CD44 960 700 37506_at PRPF40A 55660 701 40103_at EZR 7430 702 36933_at NDRG1 10397 703 36032_at HSPB11 51668 704 37003_at CD63 967 705 33457_at C3orf63 23272 706 38782_at GTF2H1 2965 707 41235_at ATF4 468 708 41695_at ZBTB43 23099 709 1981_s_at MAX 4149 710 35943_s_at GABPB1 2553 711 280_g_at NR4A1 3164 712 40268_at FOSL2 2355 713 37338_at PRPSAP1 5635 714 41451_s_at SAR1A 56681 715 37585_at SNRPA1 6627 716 41219_at USP34 9736 717 32159_at KRAS 3845 718 35957_at SNN 8303 719 40022_at FKTN 2218 720 1856_at REL 5966 721 2037_s_at RPS6KB1 6198 722 39131_at UPF3A 65110 723 41320_s_at LRRFIP1 9208 724 38089_at UBAP2L 9898 725 38661_at RBM38 55544 726 37532_at ACADM 34 727 35843_at NEK9 91754 728 525_g_at PMS1 5378 729 37581_at PPP6C 5537 730 36673_at MPI 4351 731 34787_at NRD1 4898 732 39391_at STAMBP 10617 733 40476_s_at FOXK2 3607 734 40555_at RHOQ 23433 735 35143_at FAM49A 81553 736 33761_s_at NA NA 737 749_at CAD 790 738 38501_s_at ITGB3BP 23421 739 674_g_at MTHFD1 4522 740 35983_at WDR18 57418 741 37980_at CIR1 9541 742 33334_at ACYP1 97 743 853_at NFE2L2 4780 744 1784_s_at ARID4A 5926 745 1433_g_at SMAD3 4088 746 37127_at NLRP1 22861 747 39710_at C5orf13 9315 748 37955_at CNPY2 10330 749 40891_f_at LAGE3 8270 750 40579_at AGFG1 3267 751 35253_at GAB2 9846 752 38505_at EIF2C2 27161 753 493_at CSNK1D 1453 754 38768_at HADH 3033 755 41140_at IFNGR2 3460 756 32541_at PPP3CC 5533 757 40092_at BAZ2A 11176 758 32756_at ECH1 1891 759 39794_at USP8 9101 760 37047_at NPC1 4864 761 35326_at YIF1A 10897 762 38763_at SORD 6652 763 40828_at ARHGEF7 8874 764 38666_at CYTH1 9267 765 41812_s_at NUP210 23225 766 38720_at CCT7 10574 767 38094_at HNRNPAB 3182 768 41634_at SECISBP2L 9728 769 31864_at MPHOSPH6 10200 770 39387_at SEPHS1 22929 771 38410_at CETN2 1069 772 38811_at ATIC 471 773 35631_at POLR2H 5437 774 39695_at CD55 1604 775 33326_at RAB21 23011 776 38082_at SMCHD1 23347 777 39056_at PAICS 10606 778 38278_at ARID5A 10865 779 32916_at PTPRE 5791 780 39044_s_at DGKD 8527 781 40898_at SQSTM1 8878 782 34862_at SCCPDH 51097 783 1942_s_at CDK4 1019 784 35758_at RUVBL2 10856 785 31842_at BCS1L 617 786 32801_at KIAA0317 9870 787 40704_at PIK3CA 5290 788 36200_at EHMT2 10919 789 35141_at RNASEH2A 10535 790 36076_g_at RABL4 11020 791 34274_at RBM16 22828 792 41160_at MBD3 53615 793 33443_at SERINC1 57515 794 241_g_at SRM 6723 795 40140_at RNF103 7844 796 34484_at ARFGEF2 10564 797 41577_at PPP1R16B 26051 798 39516_at POP5 51367 799 38481_at RPA1 6117 800 109_at RABEPK 10244 801 39809_at HBP1 26959 802 38780_at AKR1A1 10327 803 1985_s_at NME1 4830 804 1038_s_at IFNGR1 3459 805 744_at DHX8 1659 806 35251_at HIVEP1 3096 807 40549_at CDK5 1020 808 37311_at TALDO1 6888 809 35845_at SEC24B 10427 810 33863_at HYOU1 10525 811 34651_at COMT 1312 812 39582_at CYLD 1540 813 36185_at AARS 16 814 37982_at DCI 1632 815 880_at FKBP1A 2280 816 33409_at FKBP2 2286 817 38668_at GPATCH8 23131 818 35615_at NA NA 819 32854_at FBXW11 23291 820 35802_at FNBP4 23360 821 34394_at ADNP 23394 822 37694_at PHF3 23469 823 38685_at STX12 23673 824 34845_at SAMM50 25813 825 41729_at ARIH1 25820 826 34821_at CCDC28A 25901 827 34347_at NDUFAF3 25915 828 40811_at ZNF451 26036 829 37537_at TRIM23 373 830 37181_at MPV17 4358 831 38257_at NDUFS8 4728 832 1695_at NEDD8 4738 833 39746_at POLR2B 5431 834 503_at POLR2L 5441 835 37828_at RSBN1 54665 836 32665_at PPM1B 5495 837 1383_at PPP2R2A 5520 838 36110_at RAB5A 5868 839 35777_at RNF4 6047 840 35656_at RNF6 6049 841 34735_at ROCK1 6093 842 39964_at RP2 6102 843 37271_at TAF6 6878 844 36653_g_at UROS 7390 845 41436_at ZMYM2 7750 846 38073_at RNMT 8731 847 35008_at PER2 8864 848 37361_at FIBP 9158 849 37748_at KIAA0232 9778 850 36942_at KIAA0174 9798 851 34875_r_at RB1CC1 9821 852 40591_at CDC27 996 853 32850_at NUP153 9972 854 39231_at CHD1 1105 855 33161_at SLC38A10 124565 856 35163_at FOXJ3 22887 857 41776_at ATOX1 475 858 35835_at ANAPC5 51433 859 34827_at ULK1 8408 860 39897_at YTHDC1 91746 861 39685_at ATXN10 25814 862 39088_at TMEM147 10430 863 36135_at EBNA1BP2 10969 864 38718_at COG4 25839 865 32792_at SYF2 25949 866 783_at WWP1 11059 867 41258_at NA NA 868 38759_at BTN3A2 11118 869 1052_s_at CEBPD 1052 870 160041_at PTPN18 26469 871 39286_at TOB2 10766 872 38628_at KAT2A 2648 873 32544_s_at RSU1 6251 874 36679_at SRPR 6734 875 37357_at GCSH 2653 876 969_s_at NA NA 877 777_at GDI2 2665 878 39133_at BLOC1S1 2647 879 1782_s_at STMN1 3925 880 34400_at UQCRQ 27089 881 34803_at USP12 219333 882 35199_at WDR37 22884 883 37325_at FDPS 2224 884 32343_at EPB41 2035 885 34716_at SFRS13A 10772 886 33307_at RRP7A 27341 887 31691_g_at GLUD1 2746 888 34106_at GNA12 2768 889 35779_at VPS45 11311 890 37904_s_at GNL1 2794 891 34325_at PQBP1 10084 892 1102_s_at NR3C1 2908 893 38518_at SCML2 10389 894 36630_at TSC22D3 1831 895 38242_at BLNK 29760 896 37965_at PARVB 29780 897 38732_at CLNS1A 1207 898 39162_at GTF2H5 404672 899 39086_g_at SSBP1 6742 900 36536_at SCHIP1 29970 901 38381_at STX3 6809 902 31869_at SWAP70 23075 903 41758_at TMEM184B 25829 904 38341_at STAU2 27067 905 35934_at EIF2S3 1968 906 41256_at EEF1D 1936 907 40116_at PFKL 5211 908 40325_at NTHL1 4913 909 41734_at DENND3 22898 910 37344_at NA NA 911 41609_at HLA-DMB 3109 912 38833_at HLA-DPA1 3113 913 32625_at NPR1 4881 914 37600_at ECM1 1893 915 40705_at RAPGEF3 10411 916 1249_at GAB1 2549 917 37170_at BMP2K 55589 918 1183_at CCL17 6361 919 41406_at INTS3 65123 920 41097_at TERF2 7014 921 266_s_at CD24 100133941 922 35794_at PSD3 23362 923 35350_at CHST15 51363 924 38096_f_at HLA-DPB1 3115 925 37039_at HLA-DRA 3122 926 35016_at CD74 972 927 33261_at NA NA 928 39372_at FADS1 3992 929 40954_at FXYD2 486 930 34220_at SFMBT1 51460 931 41257_at CAST 831 932 31898_at EDEM1 9695 933 37563_at SRGAP3 9901 934 35017_f_at HLA-J 3137 935 599_at HLX 3142 936 41231_f_at HMGN2 3151 937 39182_at EMP3 2014 938 33896_at EP300 2033 939 32408_s_at NA NA 940 33831_at CREBBP 1387 941 32081_at CIT 11113 942 37347_at CKS1B 1163 943 33266_at AURKB 9212 944 39348_at PRMT2 3275 945 37720_at HSPD1 3329 946 39432_at B4GALT4 8702 947 1104_s_at NA NA 948 36785_at HSPB1 3315 949 32316_s_at HSP90AA1 3320 950 39353_at HSPE1 3336 951 752_s_at DNAJB1 3337 952 32640_at ICAM1 3383 953 38125_at SERPINE1 5054 954 37819_at MDM1 56890 955 34172_s_at SFRS17A 8227 956 32245_at METTL3 56339 957 39743_at C1orf123 54987 958 1622_at MAP2K3 5606 959 794_at PTPN6 5777 960 40720_at TRAF3IP3 80342 961 32070_at PTPRCAP 5790 962 592_at PSMC3 5702 963 38201_at BCAT1 586 964 1590_s_at HRAS 3265 965 33687_at CG012 116829 966 41767_r_at GOLGA8A 23015 967 32818_at TNC 3371 968 39771_at RHOBTB1 9886 969 32125_at THOC2 57187 970 1470_at POLD2 5425 971 32914_f_at C19orf29 58509 972 1917_at RAF1 5894 973 652_g_at RPA3 6119 974 33614_at NA NA 975 31695_g_at RSC1A1 6248 976 39712_at S100A13 6284 977 41316_s_at SAFB 6294 978 36207_at SEC14L1 6397 979 854_at BLK 640 980 40165_at TSPYL2 64061 981 39709_at SEPW1 6415 982 35626_at SGSH 6448 983 32816_at SGTA 6449 984 33321_r_at NA NA 985 40290_f_at ST3GAL1 6482 986 32745_at MRPL40 64976 987 36174_at MARCKSL1 65108 988 39313_at WNK1 65125 989 34356_at MED21 9412 990 34362_at SLC2A5 6518 991 40159_r_at NA NA 992 1341_at SPI1 6688 993 604_at BRCA1 672 994 548_s_at SYK 6850 995 40202_at KLF9 687 996 802_at TAF12 6883 997 36825_at TRIM22 10346 998 35735_at GBP1 2633 999 37468_at JAK2 3717 1000 34811_at ATP5G3 518 1001 32775_r_at PLSCR1 5359 1002 1715_at TNFSF10 8743 1003 38517_at IRF9 10379 1004 37641_at IFI44 10561 1005 36927_at IFI44L 10964 1006 35718_at SP110 3431 1007 38584_at IFIT3 3437 1008 36412_s_at IRF7 3665 1009 37014_at MX1 4599 1010 879_at MX2 4600 1011 38389_at OAS1 4938 1012 39263_at OAS2 4939 1013 35583_at XAF1 54739 1014 38662_at NA NA 1015 AFFX-HUMISGF3A/M97935_3_at STAT1 6772 1016 38549_at RSAD2 91543 1017 1107_s_at ISG15 9636 1018 40153_at TAP1 6890 1019 32649_at TCF7 6932 1020 1110_at NA NA 1021 40667_at CD6 923 1022 910_at TK1 7083 1023 1710_s_at TOP1 7150 1024 1814_at TGFBR2 7048 1025 34003_at TPI1 7167 1026 40936_at CRIM1 51232 1027 34730_g_at TRO 7216 1028 572_at TTK 7272 1029 36992_at TXN 7295 1030 504_at UBE2D3 7323 1031 35214_at UGDH 7358 1032 1357_at USP4 7375 1033 737_at POM121L1P 25812 1034 518_at NR1H2 7376 1035 37686_s_at UNG 7374 1036 35274_at AP1G1 164 1037 34642_at YWHAZ 7534 1038 37759_at LAPTM5 7805 1039 37266_at ZNF32 7580 1040 41103_at BRPF1 7862 1041 41696_at GGCT 79017 1042 38656_s_at TMEM106C 79022 1043 32051_at ALG8 79053 1044 37242_at FTO 79068 1045 39693_at TMEM109 79073 1046 41047_at C9orf16 79095 1047 41809_at C7orf23 79161 1048 34880_at RBM42 79171 1049 35175_f_at NA NA 1050 649_s_at CXCR4 7852 1051 38659_at SHOC2 8036 1052 31431_at FCGRT 2217 1053 34768_at TMX1 81542 1054 40721_g_at TRAF3IP3 80342 1055 41159_at CLTC 1213 1056 37908_at GNG11 2791 1057 32724_at PHYH 5264 1058 41073_at LGR5 8549 1059 37960_at CHST2 9435 1060 39301_at CAPN3 825 1061 31873_at NAA10 8260 1062 37685_at PICALM 8301 1063 36757_at NA NA 1064 32819_at HIST1H2BK 85236 1065 34157_f_at HIST1H2AL 8332 1066 31522_f_at HIST1H2BF 8343 1067 32980_f_at HIST1H2BC 8347 1068 35576_f_at HIST1H2BL 8340 1069 31528_f_at HIST1H2BM 8342 1070 36347_f_at HIST1H2BN 8341 1071 37018_at HIST1H1C 3006 1072 35127_at HIST1H2AE 3012 1073 286_at NA NA 1074 34964_at HIST1H3D 8351 1075 31768_at HIST1H2AI 8329 1076 31751_f_at HIST1H4L 8368 1077 31521_f_at NA NA 1078 40263_at ZFPL1 7542 1079 36864_at PEX3 8504 1080 38003_s_at DGKZ 8525 1081 1377_at NFKB1 4790 1082 32510_at AKR7A2 8574 1083 40124_at RUVBL1 8607 1084 34891_at DYNLL1 8655 1085 37332_r_at ALDH4A1 8659 1086 35632_at CBLB 868 1087 40696_at RIPK1 8737 1088 38139_at FPGT 8790 1089 38663_at BANF1 8815 1090 38035_at MTMR6 9107 1091 38726_at DPM2 8818 1092 39955_at DLEU2 8847 1093 36136_at TP53I11 9537 1094 37493_at CSF2RB 1439 1095 753_at NID2 22795 1096 37225_at KANK1 23189 1097 39614_at KIAA0802 23255 1098 37625_at IRF4 3662 1099 38340_at NA NA 1100 33781_s_at UBE2M 9040 1101 38269_at PRKD2 25865 1102 33706_at SART1 9092 1103 34609_g_at GNB2L1 10399 1104 37078_at CD247 919 1105 36180_s_at MAPKAPK2 9261 1106 33250_at WDR46 9277 1107 39389_at CD9 928 1108 39314_at ACVR2B 93 1109 36813_at TRIP13 9319 1110 37348_s_at HMGN3 9324 1111 38522_s_at CD22 933 1112 32190_at FADS2 9415 1113 41409_at C1orf38 9473 1114 38966_at TECR 9524 1115 35739_at MTMR3 8897 1116 34411_at PAPSS1 9061 1117 40134_at ATP5J2 9551 1118 39773_at C14orf1 11161 1119 33788_at ENTPD4 9583 1120 39604_at CYTIP 9595 1121 40082_at ACSL1 2180 1122 1785_at KDM5A 5927 1123 38018_g_at CD79A 973 1124 35681_r_at ZEB2 9839 1125 41699_f_at BRD1 23774 1126 38076_at ATP5G1 516 1127 40581_at TRIO 7204 1128 33162_at INSR 3643 1129 39879_s_at NA NA 1130 35430_at MED6 10001 1131 33886_at ABI1 10006 1132 35494_at SLC2A3P1 100128062 1133 31463_s_at NA NA 1134 36023_at LOC100129361 100129361 1135 32433_at RPL15 6138 1136 33836_at NA NA 1137 35688_g_at MTCP1NB 100272147 1138 38810_at HDAC5 10014 1139 37569_at PDCD6 10016 1140 41642_at NA NA 1141 33047_at BCL2L11 10018 1142 36515_at GNE 10020 1143 34756_g_at PARP2 10038 1144 38843_at HMGXB4 10042 1145 41233_at DNAJB6 10049 1146 34878_at SMC4 10051 1147 34814_at UBA2 10054 1148 1933_g_at ABCC5 10057 1149 357_at DNM1L 10059 1150 40427_at COX17 10063 1151 34372_at HUWE1 10075 1152 35831_at ATP9A 10079 1153 38392_at ARPC5 10092 1154 39043_at NA NA 1155 35271_at ACTR3 10096 1156 35733_at ACTR2 10097 1157 38612_at TSPAN3 10099 1158 40712_at ADAM8 101 1159 41202_s_at CTDSP2 10106 1160 41754_at LRPPRC 10128 1161 41750_at PDIA6 10130 1162 1468_at TRAP1 10131 1163 41743_i_at OPTN 10133 1164 41724_at BCAP31 10134 1165 33849_at NAMPT 10135 1166 38573_at YAF2 10138 1167 40631_at TOB1 10140 1168 36506_at AKAP9 10142 1169 41133_at G3BP1 10146 1170 32223_at SFRS14 10147 1171 36448_at ABI2 10152 1172 32194_at CEBPZ 10153 1173 32193_at PLXNC1 10154 1174 33425_at TRIM28 10155 1175 40903_at ATP6AP2 10159 1176 32148_at FARP1 10160 1177 33710_at LPCAT3 10162 1178 38328_at SLC25A13 10165 1179 32803_at CNIH 10175 1180 40870_g_at RBM6 10180 1181 1556_at RBM5 10181 1182 37542_at LHFPL2 10184 1183 40235_at TNK2 10188 1184 379_at TXNDC9 10190 1185 35970_g_at MPHOSPH9 10198 1186 40797_at ADAM10 102 1187 31858_at NUTF2 10204 1188 31851_at TRIM13 10206 1189 31847_at USPL1 10208 1190 40203_at EIF1 10209 1191 1207_at CDK6 1021 1192 38568_at TOPORS 10210 1193 40635_at FLOT1 10211 1194 149_at DDX39 10212 1195 33247_at PSMD14 10213 1196 40196_at CTDSPL 10217 1197 1969_s_at CDK7 1022 1198 37875_at GPA33 10223 1199 34961_at CD96 10225 1200 32080_at MFSD10 10227 1201 41663_at STX6 10228 1202 38361_g_at RASGRP2 10235 1203 39792_at HNRNPR 10236 1204 35140_at CDK8 1024 1205 40063_at CALCOCO2 10241 1206 32173_at HRSP12 10247 1207 387_at CDK9 1025 1208 41737_at SRRM1 10250 1209 38767_at SPRY1 10252 1210 33700_at SPRY2 10253 1211 35151_at CDK2AP2 10263 1212 35668_at RAMP1 10267 1213 33912_at ZMPSTE24 10269 1214 33847_s_at CDKN1B 1027 1215 35138_at AKAP8 10270 1216 39246_at STAG1 10274 1217 41276_at SAP18 10284 1218 38040_at SMNDC1 10285 1219 34268_at RGS19 10287 1220 39221_at LILRB2 10288 1221 33351_at EIF1B 10289 1222 34733_at SF3A1 10291 1223 32832_at MAEA 10296 1224 32802_at MARCH6 10299 1225 33791_at DLEU1 10301 1226 34544_at ZNF267 10308 1227 35166_at DSCR3 10311 1228 36028_at TCIRG1 10312 1229 39441_at LANCL1 10314 1230 38970_s_at TNIP1 10318 1231 834_at IKZF1 10320 1232 37964_at PCGF3 10336 1233 33113_at CITED2 10370 1234 40567_at NA NA 1235 33678_i_at TUBB2C 10383 1236 38241_at BTN3A3 10384 1237 36190_at CDR2 1039 1238 34772_at CORO2B 10391 1239 41187_at MYL12B 103910 1240 33267_at ATP8A1 10396 1241 38748_at ADARB1 104 1242 39298_at ST3GAL6 10402 1243 40041_at NDC80 10403 1244 32607_at BASP1 10409 1245 41745_at IFITM3 10410 1246 38106_at NSA2 10412 1247 35277_at SPON1 10418 1248 38821_at PGRMC2 10424 1249 38353_at TUBGCP3 10426 1250 34210_at CD52 1043 1251 41460_at NA NA 1252 39396_at LYPLA1 10434 1253 39357_at EMG1 10436 1254 39782_at C1D 10438 1255 32830_g_at TIMM17A 10440 1256 33827_at N4BP2L2 10443 1257 41530_at ACAA2 10449 1258 39800_s_at HAX1 10456 1259 36013_at SLC30A9 10463 1260 36012_at PIBF1 10464 1261 34737_at COG5 10466 1262 35824_at ZNF238 10472 1263 35738_at HMGN4 10473 1264 35760_at ATP5H 10476 1265 34850_at UBE2E3 10477 1266 36542_at SLC9A6 10479 1267 35302_at NXF1 10482 1268 39099_at SEC23A 10484 1269 935_at CAP1 10487 1270 40122_at SYNCRIP 10492 1271 38470_i_at APPBP2 10513 1272 1020_s_at CIB1 10519 1273 38142_at ZNF211 10520 1274 35363_at DDX17 10521 1275 35771_at DEAF1 10522 1276 35255_at IPO7 10527 1277 34882_at NOP56 10528 1278 34839_at PITRM1 10531 1279 39219_at CEBPG 1054 1280 38475_at DCTN2 10540 1281 38479_at ANP32B 10541 1282 38054_at HBXIP 10542 1283 38435_at PRDX4 10549 1284 39091_at ARL6IP5 10550 1285 38824_at HTATIP2 10553 1286 38818_at SPTLC1 10558 1287 37895_at SLC35A1 10559 1288 39176_f_at CEL 1056 1289 38306_at ARFGEF1 10565 1290 35759_at CCT2 10576 1291 411_i_at IFITM2 10581 1292 35753_at PRPF8 10594 1293 40979_at AHSA1 10598 1294 31894_at CENPC1 1060 1295 33362_at CDC42EP3 10602 1296 38978_at PAIP1 10605 1297 38639_at MXD4 10608 1298 40220_at HEXIM1 10614 1299 32120_at SPAG5 10615 1300 32203_at RBCK1 10616 1301 38993_r_at TGOLN2 10618 1302 37173_at CENPE 1062 1303 33752_at IVNS1ABP 10625 1304 33447_at MYL12A 10627 1305 31508_at TXNIP 10628 1306 38693_at ATP5L 10632 1307 31874_at GAS2L1 10634 1308 40497_at TUSC4 10641 1309 37558_at IGF2BP3 10643 1310 38716_at CAMKK2 10645 1311 35642_at MTX2 10651 1312 34348_at SPINT2 10653 1313 31786_at KHDRBS3 10656 1314 39346_at KHDRBS1 10657 1315 33207_at CELF1 10658 1316 35319_at CTCF 10664 1317 36514_at CGRRF1 10668 1318 35316_at RRAGA 10670 1319 34781_at DCTN6 10671 1320 32536_at EBP 10682 1321 39767_at CCT8 10694 1322 35232_f_at CETN3 1070 1323 37646_at POLD3 10714 1324 35317_at MGEA5 10724 1325 32548_at PTGES3 10728 1326 40988_at YME1L1 10730 1327 35614_at TCFL5 10732 1328 39156_at RFPL3S 10737 1329 35756_at GIPC1 10755 1330 36139_at TRAF3IP2 10758 1331 40564_at NUP50 10762 1332 39713_at KDM5B 10765 1333 34237_at HBS1L 10767 1334 34728_g_at AHCYL1 10768 1335 41544_at PLK2 10769 1336 33865_at ZMYND11 10771 1337 36872_at ARPP19 10776 1338 41621_i_at ZNF266 10781 1339 40691_at ZNF274 10782 1340 37276_at IQGAP2 10788 1341 32533_s_at VAMP5 10791 1342 35026_f_at ZNF273 10793 1343 40074_at MTHFD2 10797 1344 37471_at RPP40 10799 1345 41220_at SEPT9 10801 1346 34199_at SEC24A 10802 1347 35216_at ME3 10873 1348 38575_at MALT1 10892 1349 41832_s_at JTB 10899 1350 33134_at ADCY3 109 1351 32654_g_at BRD8 10902 1352 35267_g_at BLCAP 10904 1353 33632_g_at TXNL4A 10907 1354 34874_at PNPLA6 10908 1355 34855_at PAPOLA 10914 1356 39426_at TCERG1 10915 1357 34859_at MAGED2 10916 1358 32539_at COPS8 10920 1359 36186_at RNPS1 10921 1360 36171_at SUB1 10923 1361 36628_at RALBP1 10928 1362 36631_at PRDX3 10935 1363 40098_at EHD1 10938 1364 34315_at AFG3L2 10939 1365 37389_at C11orf58 10944 1366 37379_at SF3A3 10946 1367 37334_at HNRNPA0 10949 1368 37218_at BTG3 10950 1369 37304_at CBX1 10951 1370 32564_at SEC61B 10952 1371 37050_r_at TOMM34 10953 1372 37007_at SERINC3 10955 1373 36980_at PNRC1 10957 1374 36972_at TMED2 10959 1375 36945_at ERP29 10961 1376 36625_at NA NA 1377 32529_at CKAP4 10970 1378 32530_at YWHAQ 10971 1379 35754_at TMED10 10972 1380 36045_at ASCC3 10973 1381 38451_at UQCR11 10975 1382 36577_at FERMT2 10979 1383 37406_at MAPRE2 10982 1384 1836_at CCNI 10983 1385 1789_at COPS5 10987 1386 37659_at IMMT 10989 1387 531_at GLIPR1 11010 1388 36491_at TMSB15A 11013 1389 39080_at KDELR2 11014 1390 35193_at RCBTB2 1102 1391 32921_at NA NA 1392 1633_g_at PIM2 11040 1393 41643_at NA NA 1394 33380_at PAPD7 11044 1395 38005_at SLC35D2 11046 1396 39142_at NUDT21 11051 1397 39114_at C10orf10 11067 1398 34707_at CHD3 1107 1399 38272_at DUSP14 11072 1400 38834_at TOPBP1 11073 1401 36137_at CHD4 1108 1402 32045_at DIDO1 11083 1403 40250_at KRR1 11103 1404 32629_f_at BTN3A1 11119 1405 41000_at FOXN3 1112 1406 32673_at BTN2A1 11120 1407 36005_at SFRS16 11129 1408 38223_at TBC1D8 11138 1409 34376_at PKIG 11142 1410 39984_g_at GLMN 11146 1411 38976_at CORO1A 11151 1412 33350_s_at WDR45 11152 1413 36008_at PTP4A3 11156 1414 35991_at LSM6 11157 1415 40355_at WDHD1 11169 1416 34402_at STRAP 11171 1417 37971_at BAZ1A 11177 1418 34226_at MAP4K5 11183 1419 33916_at NISCH 11188 1420 31675_s_at NA NA 1421 35213_at WBP4 11193 1422 40424_at PROSC 11212 1423 38510_at IRAK3 11213 1424 34657_at AKAP11 11215 1425 32278_at CHML 1122 1426 38555_at DUSP10 11221 1427 37726_at MRPL3 11222 1428 34349_at SEC63 11231 1429 33244_at CHN2 1124 1430 38753_at XPOT 11260 1431 685_f_at TUBA3D 113457 1432 40585_at ADCY7 113 1433 35695_at LYST 1130 1434 38974_at PARK7 11315 1435 38647_at COPE 11316 1436 33746_at ECD 11319 1437 32116_at TMC6 11322 1438 35180_at LARP4 113251 1439 37364_at PHB2 11331 1440 38115_at TUSC2 11334 1441 38084_at CBX3 11335 1442 36968_s_at EXOSC8 11340 1443 35811_at RNF13 11342 1444 35792_at MGLL 11343 1445 38350_f_at NA NA 1446 39566_at NA NA 1447 33770_at CHUK 1147 1448 41438_at OSBPL8 114882 1449 40803_at TMEM123 114908 1450 35356_at MRFAP1L1 114932 1451 33800_at ADCY9 115 1452 38972_at KCTD12 115207 1453 39864_at CIRBP 1153 1454 34338_at TBCB 1155 1455 40343_at FAM36A 116228 1456 40690_at CKS2 1164 1457 38074_at AP3S1 1176 1458 38069_at CLCN7 1186 1459 36131_at CLIC1 1192 1460 32833_at CLK1 1195 1461 36115_at CLK3 1198 1462 33102_at ADD3 120 1463 32824_at TPP1 1200 1464 34378_at PLIN2 123 1465 41084_at ZNF428 126299 1466 36564_at RNF19B 127544 1467 37707_i_at ADH5 128 1468 38262_at MBOAT2 129642 1469 41529_g_at FAM168B 130074 1470 36962_at COPA 1314 1471 34326_at COPB1 1315 1472 37026_at KLF6 1316 1473 36015_at NA NA 1474 1891_at MAP3K8 1326 1475 39027_at COX4I1 1327 1476 39443_s_at COX5B 1329 1477 34777_at ADM 133 1478 41206_r_at COX6A1 1337 1479 40872_at COX6B1 1340 1480 36165_at COX6C 1345 1481 41760_at COX7A2 1347 1482 36687_at COX7B 1349 1483 34876_at CPD 1362 1484 35228_at CPT1B 1375 1485 32059_at UBXN2B 137886 1486 37535_at CREB1 1385 1487 37575_at ATF2 1386 1488 39438_at CREBL2 1389 1489 35301_at CRKL 1399 1490 34752_at NEK7 140609 1491 38148_at CRY1 1407 1492 36033_at SFRS12 140890 1493 1287_at PARP1 142 1494 37303_at PARP4 143 1495 37733_at MAPK14 1432 1496 38804_at CSE1L 1434 1497 596_s_at CSF3R 1441 1498 36784_at CSHL1 1444 1499 41672_at FBXL14 144699 1500 40184_at CSNK1A1 1452 1501 38019_at CSNK1E 1454 1502 41401_at CSRP2 1466 1503 41006_at B3GNTL1 146712 1504 40787_at WIPF2 147179 1505 35816_at CSTB 1476 1506 41183_at CSTF3 1479 1507 41308_at CTBP1 1487 1508 40780_at CTBP2 1488 1509 36566_at CTNS 1497 1510 40777_at CTNNB1 1499 1511 40444_s_at CTNND1 1500 1512 32441_at CTPS 1503 1513 32372_at CTSB 1508 1514 34866_at NA NA 1515 40718_at CTSW 1521 1516 31823_at CUX1 1523 1517 39600_at PAQR3 152559 1518 38458_at CYB5A 1528 1519 37975_at CYBB 1536 1520 1160_at CYC1 1537 1521 38286_at AMOT 154796 1522 32444_at ATP6V0E2 155066 1523 41604_at ANKRD46 157567 1524 34192_at VPS13B 157680 1525 40577_at TSTD2 158427 1526 33442_at PRUNE2 158471 1527 479_at DAB2 1601 1528 38413_at DAD1 1603 1529 32716_at DGKA 1606 1530 36199_at DAP 1611 1531 40049_at DAPK1 1612 1532 32615_at DARS 1615 1533 37692_at DBI 1622 1534 38423_at FAM134C 162427 1535 37981_at DBN1 1627 1536 886_at DCK 1633 1537 631_g_at DCTD 1635 1538 1641_s_at DDB1 1642 1539 1243_at DDB2 1643 1540 1911_s_at GADD45A 1647 1541 39069_at AEBP1 165 1542 38791_at DDOST 1650 1543 37663_at DDX1 1653 1544 39744_at DDX3X 1654 1545 34647_at DDX5 1655 1546 36153_at DHX9 1660 1547 831_at DDX10 1662 1548 35306_at DHX15 1665 1549 33299_at GPR125 166647 1550 34191_at DCP2 167227 1551 34937_at DFFB 1677 1552 39837_s_at ZNF467 168544 1553 41872_at DFNA5 1687 1554 38312_at OLFML2A 169611 1555 38648_at ZNF384 171017 1556 34396_at ASXL1 171023 1557 33399_at C14orf147 171546 1558 36668_at CYB5R3 1727 1559 34829_at DKC1 1736 1560 36163_at DLD 1738 1561 40488_at DMD 1756 1562 37213_at DNASE1L1 1774 1563 37300_at DYNC1H1 1778 1564 38253_at AGL 178 1565 35787_at NA NA 1566 37333_at DNMT1 1786 1567 34168_at DNTT 1791 1568 32704_at DOCK2 1794 1569 816_g_at DOK1 1796 1570 37413_at DPEP1 1800 1571 38220_at DPYD 1806 1572 40607_at DPYSL2 1808 1573 32621_at DR1 1810 1574 32168_s_at RCAN1 1827 1575 39673_i_at ECM2 1842 1576 1005_at DUSP1 1843 1577 1292_at DUSP2 1844 1578 529_at DUSP5 1847 1579 41193_at DUSP6 1848 1580 1562_g_at DUSP8 1850 1581 36946_at DYRK1A 1859 1582 32234_at TOR1A 1861 1583 41632_at E2F3 1871 1584 1044_s_at E2F5 1875 1585 37016_at ECHS1 1892 1586 40821_at AHCY 191 1587 36960_at PHC2 1912 1588 40886_at EEF1A1 1915 1589 35748_at EEF1B2 1933 1590 1676_s_at EEF1G 1937 1591 36587_at EEF2 1938 1592 40425_at EFNA1 1942 1593 36488_at MEGF9 1955 1594 40516_at AHR 196 1595 40375_at EGR3 1960 1596 34278_at NA NA 1597 35184_at ZFC3H1 196441 1598 39784_at EIF2S1 1965 1599 1420_s_at EIF4A2 1974 1600 39110_at EIF4B 1975 1601 37752_at EIF4E 1977 1602 41785_at EIF4G2 1982 1603 32171_at EIF5 1983 1604 33305_at SERPINB1 1992 1605 40067_at ELF1 1997 1606 507_s_at ELF2 1998 1607 38313_at ABCA2 20 1608 31845_at ELF4 2000 1609 41472_at APOBEC3G 60489 1610 32085_at PIKFYVE 200576 1611 40602_at SPRED2 200734 1612 37762_at EMP1 2012 1613 35342_at PTPLB 201562 1614 39025_at NA NA 1615 32112_s_at AIM1 202 1616 2035_s_at ENO1 2023 1617 39012_g_at ENSA 2029 1618 36997_at AK1 203 1619 32585_at EPB41L2 2037 1620 1604_at EPHA5 2044 1621 39376_at HIPK1 204851 1622 41864_at STX2 2054 1623 35300_at EPRS 2058 1624 37731_at EPS15 2060 1625 2063_at ERCC5 2073 1626 914_g_at ERG 2078 1627 39079_at ERH 2079 1628 38375_at ESD 2098 1629 37318_at ETF1 2107 1630 40509_at ETFA 2108 1631 1519_at ETS2 2114 1632 34818_at ETV5 2119 1633 36313_at EVI2A 2123 1634 40019_at EVI2B 2124 1635 38642_at ALCAM 214 1636 32259_at EZH1 2145 1637 37305_at EZH2 2146 1638 41700_at F2R 2149 1639 36543_at F3 2152 1640 37015_at ALDH1A1 216 1641 38052_at F13A1 2162 1642 39799_at FABP5 2171 1643 33881_at ACSL3 2181 1644 33804_at PTK2B 2185 1645 41091_at BPTF 2186 1646 38429_at FASN 2194 1647 40454_at FAT1 2195 1648 31955_at FAU 2197 1649 41681_at ABCB7 22 1650 34677_f_at NA NA 1651 35916_s_at HNRNPA3 220988 1652 40685_at ALDH3B1 221 1653 38216_at JMJD1C 221037 1654 36821_at FAM171A1 221061 1655 38102_at EFHA1 221154 1656 37688_f_at FCGR2A 2212 1657 35007_at TWISTNB 221830 1658 40132_g_at NA NA 1659 37442_at DKFZP586I1420 222161 1660 34848_at FDFT1 2222 1661 35002_g_at KCTD20 222658 1662 33899_at ALDH9A1 223 1663 1616_at FGF9 2254 1664 2057_g_at FGFR1 2260 1665 32546_at FH 2271 1666 1971_g_at FHIT 2272 1667 38437_at CASC3 22794 1668 32827_at RRAS2 22800 1669 34337_s_at MTF2 22823 1670 36145_at PUF60 22827 1671 32215_i_at RHOBTB3 22836 1672 41179_at RNF44 22838 1673 32740_at RAB11FIP2 22841 1674 34931_at CPEB3 22849 1675 37837_at ADNP2 22850 1676 41447_at CHSY1 22856 1677 41431_at ICK 22858 1678 38649_at FNDC3A 22862 1679 41372_at KIAA0831 22863 1680 41366_at R3HDM2 22864 1681 36089_at INPP5F 22876 1682 35260_at MLXIP 22877 1683 36002_at KIAA1012 22878 1684 38729_at FKBP4 2288 1685 41503_at ZHX2 22882 1686 33885_at KIAA0907 22889 1687 34721_at FKBP5 2289 1688 34751_at ZBTB1 22890 1689 41100_at CARD8 22900 1690 37755_at BTBD3 22903 1691 35789_at TRAK1 22906 1692 35355_at DHX30 22907 1693 35720_at WDR47 22911 1694 36777_at KLRK1 22914 1695 32789_at NCBP2 22916 1696 33456_at MAPRE1 22919 1697 40779_at KIFAP3 22920 1698 39078_at SEPHS2 22928 1699 33418_at RAB3GAP1 22930 1700 38036_at RPIA 22934 1701 37656_at SCAP 22937 1702 31794_at NT5C2 22978 1703 41267_at TCF25 22980 1704 34276_at NINL 22981 1705 33408_at DIP2C 22982 1706 33360_at KDM2A 22992 1707 39141_at ABCF1 23 1708 32769_at WDFY3 23001 1709 33753_at DAAM1 23002 1710 38869_at PLCH1 23007 1711 32237_at NA NA 1712 32172_at SPEN 23013 1713 32169_at FBXO21 23014 1714 41224_at SNRNP200 23020 1715 41191_at PALLD 23022 1716 41122_at KDM1A 23028 1717 33223_at MAST3 23031 1718 40855_at SAMD4A 23034 1719 32735_at PHLPP2 23035 1720 40838_at ZNF292 23036 1721 40824_at XPO7 23039 1722 40468_at FNBP1 23048 1723 40411_at NCOA6 23054 1724 40136_at TBC1D9B 23061 1725 40086_at WAPAL 23063 1726 40083_at SETX 23064 1727 40054_at FTSJD2 23070 1728 31863_at RRP1B 23076 1729 39777_at MYCBP2 23077 1730 39761_at AVL9 23080 1731 34979_at KDM4C 23081 1732 39696_at PEG10 23089 1733 34950_at ZNF423 23090 1734 39417_at CDK19 23097 1735 36589_at AKR1B1 231 1736 41457_at FAM179B 23116 1737 38980_at TAB2 23118 1738 38711_at CLASP2 23122 1739 41421_at CAMTA2 23125 1740 38688_at POGZ 23126 1741 38671_at PLXND1 23129 1742 41425_at FLI1 2313 1743 41399_at PHF8 23133 1744 41379_at SMC5 23137 1745 33133_at FLII 2314 1746 38626_at ZZEF1 23140 1747 39519_at ANKLE2 23141 1748 35039_at DCUN1D4 23142 1749 38336_at FRMD4B 23150 1750 39135_at GRAMD4 23151 1751 38826_at SEPT6 23157 1752 32749_s_at FLNA 2316 1753 38730_at MPRIP 23164 1754 38728_at NUP205 23165 1755 38487_at STAB1 23166 1756 38472_at EFR3A 23167 1757 38436_at RTF1 23168 1758 38078_at FLNB 2317 1759 38394_at GPD1L 23171 1760 37642_at FAM175B 23172 1761 37619_at METAP1 23173 1762 38098_at LPIN1 23175 1763 38067_at SEPT8 23176 1764 40191_s_at CEP68 23177 1765 40652_at PASK 23178 1766 32593_at RFTN1 23180 1767 32586_at LARP4B 23185 1768 37651_at RCOR1 23186 1769 37336_at UBXN4 23190 1770 37306_at CYFIP1 23191 1771 37036_at MDN1 23195 1772 37031_at FAM120A 23196 1773 36635_at ATP11B 23200 1774 36572_r_at ARL6IP1 23204 1775 36144_at SYT11 23208 1776 36897_at MLC1 23209 1777 1964_g_at FLT1 2321 1778 36860_at ZC3H4 23211 1779 35830_at XPO6 23214 1780 32509_at BAT2L2 23215 1781 32506_at TBC1D1 23216 1782 35762_at FBXO28 23219 1783 1065_at FLT3 2322 1784 35369_at DTX4 23220 1785 36520_at RRP12 23223 1786 41815_at SYNE2 23224 1787 40000_f_at VPS13A 23230 1788 41585_at SEL1L3 23231 1789 35980_at PLCB1 23236 1790 39929_at KIAA0922 23240 1791 35655_at ANKRD28 23243 1792 34353_at PDS5A 23244 1793 41491_s_at ATP11A 23250 1794 39621_at OTUD3 23252 1795 33930_at SCFD1 23256 1796 35177_at DDHD2 23259 1797 35167_at PPIP5K2 23262 1798 33877_s_at NA NA 1799 33835_at TSPYL4 23270 1800 34661_at CLEC16A 23274 1801 34253_at NUP160 23279 1802 35949_at MTUS2 23281 1803 41248_at CSTF2T 23283 1804 40971_at ANKS1A 23294 1805 32235_at MGRN1 23295 1806 40879_at BICD2 23299 1807 40431_at ATMIN 23300 1808 40423_at EHBP1 23301 1809 39797_at UBR2 23304 1810 31832_at TMEM194A 23306 1811 39705_at SIN3B 23309 1812 41716_at DMXL2 23312 1813 39403_at DNAJC13 23317 1814 41669_at ZCCHC11 23318 1815 37994_at FMR1 2332 1816 39382_at TRIM2 23321 1817 41478_at TTC28 23331 1818 39021_at DPY19L1 23333 1819 38342_at PHF15 23338 1820 38424_at ESYT1 23344 1821 38113_at SYNE1 23345 1822 38030_at SR140 23350 1823 33860_at UBR4 23352 1824 36588_at NA NA 1825 35847_at USP24 23358 1826 35780_at OBSL1 23363 1827 35359_at PUM2 23369 1828 36537_at ARHGEF18 23370 1829 36474_at KIAA0776 23376 1830 41595_at KIAA0947 23379 1831 36069_at SRGAP2 23380 1832 36066_at AHCYL2 23382 1833 34808_at SIK3 23387 1834 34785_at MED13L 23389 1835 1499_at FNTA 2339 1836 35973_at ZDHHC17 23390 1837 34764_at LARS2 23395 1838 41638_at PPWD1 23398 1839 38483_at DULLARD 23399 1840 38764_at DICER1 23405 1841 37732_at RYBP 23429 1842 32241_at TARDBP 23435 1843 38208_at SLC35A3 23443 1844 39561_at CBX6 23466 1845 39715_at CBX5 23468 1846 34796_at TRAM1 23471 1847 36170_at ETHE1 23474 1848 39093_s_at BRD4 23476 1849 39165_at ISCU 23479 1850 39169_at SEC61G 23480 1851 41667_s_at TGDS 23483 1852 38985_at LEPROTL1 23484 1853 36894_at CBX7 23492 1854 38704_at MACF1 23499 1855 38892_at KIAA0240 23506 1856 32644_at NUP188 23511 1857 40957_at SUZ12 23512 1858 32561_at KIAA0146 23514 1859 36845_at MORC3 23515 1860 38797_at SLC39A14 23516 1861 35203_at MYST4 23522 1862 37652_at CABIN1 23523 1863 33748_at HMHA1 23526 1864 41333_at ACAP2 23527 1865 1915_s_at FOS 2353 1866 41722_at NNT 23530 1867 37565_at MMD 23531 1868 33198_at ARL2BP 23568 1869 41454_at HEBP2 23593 1870 34699_at CD2AP 23607 1871 36957_at ZMYND8 23613 1872 35289_at RABGAP1 23637 1873 39967_at LDOC1 23641 1874 36948_at EID1 23741 1875 36711_at MAFF 23764 1876 307_at ALOX5 240 1877 37099_at ALOX5AP 241 1878 34345_at PRPF6 24148 1879 36048_at ZNF318 24149 1880 1635_at ABL1 25 1881 41814_at FUCA1 2517 1882 39420_at NA NA 1883 33332_at NA NA 1884 40480_s_at FYN 2534 1885 628_at FZD2 2535 1886 39434_at NA NA 1887 38630_at LASS6 253782 1888 38042_at NA NA 1889 35290_at YTHDF3 253943 1890 32624_at RALGAPA1 253959 1891 32623_at GABBR1 2550 1892 35336_at SUN2 25777 1893 40225_at GAK 2580 1894 1798_at SLC39A6 25800 1895 33936_at GALC 2581 1896 33243_at TNFAIP8 25816 1897 33378_at NIPBL 25836 1898 38717_at METTL7A 25840 1899 39806_at ASF1A 25842 1900 38698_at MOBKL3 25843 1901 38687_at ANAPC13 25847 1902 37000_at BRP44 25874 1903 38041_at GALNT1 2589 1904 36046_at RCHY1 25898 1905 36030_at IFFO1 25900 1906 36484_at GALNT3 2591 1907 39602_at MYRIP 25924 1908 33891_at CLIC4 25932 1909 41335_at NSL1 25936 1910 33433_at FAM98A 25940 1911 32807_at KBTBD2 25948 1912 33776_at RWDD3 25950 1913 38859_at SEC31B 25956 1914 41784_at SFRS18 25957 1915 40437_at TMEM87A 25963 1916 32107_at C2CD2 25966 1917 39411_at TIPARP 25976 1918 41662_at NECAP1 25977 1919 39034_at CHMP2B 25978 1920 38256_s_at NGDN 25983 1921 36875_at IBTK 25998 1922 35805_at GORASP2 26003 1923 36456_at ZZZ3 26009 1924 34800_at LRIG1 26018 1925 35722_at UPF2 26019 1926 40805_at SIPA1L1 26037 1927 34990_at SETBP1 26040 1928 41691_at UBXN7 26043 1929 39005_s_at RNF160 26046 1930 41008_at FAM169A 26049 1931 35648_at AUTS2 26053 1932 33934_at SENP6 26054 1933 39380_at ANKRD17 26057 1934 38400_at LSM14A 26065 1935 40832_s_at TOR1AIP1 26092 1936 33403_at C1orf77 26097 1937 34269_at C10orf137 26098 1938 33392_at WIPI2 26100 1939 34183_at CCDC69 26112 1940 40928_at WSB1 26118 1941 40831_at KIAA1279 26128 1942 40801_at GAPVD1 26130 1943 40441_g_at SERBP1 26135 1944 32134_at TES 26136 1945 38211_at ZBTB20 26137 1946 37161_at RSL1D1 26156 1947 36581_at GARS 2617 1948 39022_at INTS1 26173 1949 41437_at C14orf109 26175 1950 262_at AMD1 262 1951 32102_at SACS 26278 1952 39905_i_at ARFGAP3 26286 1953 39793_at GBAS 2631 1954 32643_at GBE1 2632 1955 32700_at GBP2 2634 1956 37944_at GCH1 2643 1957 38218_at GCNT1 2650 1958 34678_at MYOF 26509 1959 32117_at AATF 26574 1960 467_at OSTF1 26578 1961 38068_at AMFR 267 1962 33977_at GFI1 2672 1963 33895_at SH3YL1 26751 1964 40960_at B4GALT1 2683 1965 31951_s_at PABPC1 26986 1966 39150_at RNF11 26994 1967 37579_at CYFIP2 26999 1968 37632_s_at DNAJC2 27000 1969 35747_at NPTN 27020 1970 31884_at MLH3 27030 1971 38684_at ATP2C1 27032 1972 39977_at ZBTB11 27107 1973 36833_at GLA 2717 1974 37742_at GLB1 2720 1975 37035_at SERP1 27230 1976 39960_at COQ2 27235 1977 39363_at CHMP2A 27243 1978 37159_at AHDC1 27245 1979 32129_at RNF115 27246 1980 39509_at NA NA 1981 39009_at LSM3 27258 1982 31850_at GCLC 2729 1983 39884_g_at DIMT1L 27292 1984 37520_at ZNF330 27309 1985 39731_at RBMX 27316 1986 32674_at ZNF638 27332 1987 31492_at EIF3K 27335 1988 32695_at HTATSF1 27336 1989 40966_at STK39 27347 1990 32233_at TOR1B 27348 1991 36201_at GLO1 2739 1992 459_s_at BIN1 274 1993 34719_at GLS 2744 1994 34311_at GLRX 2745 1995 41120_at AMT 275 1996 763_at GMFB 2764 1997 40365_at GNA15 2769 1998 37307_at GNAI2 2771 1999 38581_at GNAQ 2776 2000 37450_r_at GNAS 2778 2001 38831_f_at GNB2 2783 2002 35272_at GNG5 2787 2003 37735_at NA NA 2004 36680_at NA NA 2005 34861_at GOLGA3 2802 2006 32150_at GOLGA4 2803 2007 35343_at GOT1 2805 2008 40764_at GOT2 2806 2009 37251_s_at GPM6B 2824 2010 38207_at NA NA 2011 36093_at C12orf51 283450 2012 40878_f_at HERC2P3 283755 2013 39315_at ANGPT1 284 2014 253_g_at GPR18 2841 2015 895_at MIF 4282 2016 40492_at FRYL 285527 2017 40353_at DPY19L4 286148 2018 1106_s_at NA NA 2019 1135_at GRK5 2869 2020 35653_at NA NA 2021 33931_at GPX4 2879 2022 36009_at GPX7 2882 2023 717_at TRIB2 28951 2024 32221_at MRPS18B 28973 2025 39058_at ABR 29 2026 35815_at SETD2 29072 2027 37740_r_at SLC25A5 292 2028 37187_at CXCL2 2920 2029 34022_at CXCL3 2921 2030 38986_at PDIA3 2923 2031 40435_at SLC25A6 293 2032 40645_at GSK3B 2932 2033 38386_r_at GSS 2937 2034 39054_at NA NA 2035 2003_s_at MSH6 2956 2036 869_at GTF2A2 2958 2037 37381_g_at GTF2B 2959 2038 36188_at GTF3A 2971 2039 141_s_at BRF1 2972 2040 36932_at GTF3C2 2976 2041 36918_at GUCY1A3 2982 2042 32858_at UBN1 29855 2043 905_at GUK1 2987 2044 33132_at CPSF1 29894 2045 39344_at TRA2A 29896 2046 33308_at GUSB 2990 2047 40876_at GYG1 2992 2048 38119_at GYPC 2995 2049 40901_at STRN3 29966 2050 37842_at MDFIC 29969 2051 34824_at UBQLN2 29978 2052 37915_at BAZ2B 29994 2053 40757_at GZMA 3001 2054 33386_at H1F0 3005 2055 40195_at H2AFX 3014 2056 39337_at H2AFZ 3015 2057 38576_at HIST1H2BD 3017 2058 31510_s_at H3F3B 3021 2059 40778_at HSD17B10 3028 2060 39741_at HADHB 3032 2061 37910_at HCFC1 3054 2062 31820_at HCLS1 3059 2063 38771_at HDAC1 3065 2064 34368_at HDAC2 3066 2065 36446_s_at HDGF 3068 2066 31504_at HDLBP 3069 2067 37374_at ANXA4 307 2068 37845_at NCKAP1L 3071 2069 35418_at HEXA 3073 2070 34888_at HEXB 3074 2071 37901_at PIK3R4 30849 2072 39416_at TAX1BP3 30851 2073 39082_at ANXA6 309 2074 1009_at HINT1 3094 2075 34380_at STOML2 30968 2076 36175_s_at HIVEP2 3097 2077 37670_at ANXA7 310 2078 41237_at HLA-A 3105 2079 38570_at HLA-DOB 3112 2080 36108_at HLA-DQB1 3119 2081 32321_at HLA-E 3133 2082 38065_at HMGB2 3148 2083 306_s_at HMGN1 3150 2084 39704_s_at HMGA1 3159 2085 36863_at HMMR 3161 2086 34987_s_at HNRNPA1 3178 2087 41292_at HNRNPH1 3187 2088 41131_f_at HNRNPH2 3188 2089 41283_at HNRNPH3 3189 2090 38654_at HNRNPU 3192 2091 873_at HOXA5 3202 2092 37809_at HOXA9 3205 2093 41448_at HOXA10 3206 2094 35693_at HPCAL1 3241 2095 32570_at HPGD 3248 2096 37640_at HPRT1 3251 2097 32825_at PRMT1 3276 2098 37393_at HES1 3280 2099 31906_at HSBP1 3281 2100 36578_at BIRC2 329 2101 36626_at HSD17B4 3295 2102 32087_at HSF2 3298 2103 276_at DNAJA1 3301 2104 1480_at HSPA4 3308 2105 36614_at HSPA5 3309 2106 40637_at HSPA8 3312 2107 41510_s_at HSPA9 3313 2108 33944_at APLP2 334 2109 40827_at IARS 3376 2110 38453_at ICAM2 3384 2111 402_s_at ICAM3 3385 2112 33186_i_at NA NA 2113 32195_at MSL1 339287 2114 32941_at IRF8 3394 2115 36617_at ID1 3397 2116 41215_s_at NA NA 2117 37043_at ID3 3399 2118 39023_at IDH1 3417 2119 40112_at IDH3B 3420 2120 36985_at IDI1 3422 2121 40814_at IDS 3423 2122 34391_at IGBP1 3476 2123 160027_s_at IGF2R 3482 2124 40422_at IGFBP2 3485 2125 2062_at IGFBP7 3490 2126 34098_f_at IGHG1 3500 2127 41136_s_at APP 351 2128 37006_at IGJ 3512 2129 40818_at RBPJ 3516 2130 34310_at APRT 353 2131 38500_at TMED7 51014 2132 38514_at IGLL1 3543 2133 218_at IK 3550 2134 1076_at IL1A 3552 2135 1520_s_at IL1B 3553 2136 38546_at IL1RAP 3556 2137 1506_at IL2RG 3561 2138 38299_at IL6 3569 2139 36227_at IL7R 3575 2140 33228_g_at IL10RB 3588 2141 496_s_at IL11RA 3590 2142 38488_s_at IL15 3600 2143 36189_at ILF2 3608 2144 32751_at ILF3 3609 2145 35365_at ILK 3611 2146 32697_at IMPA1 3612 2147 36496_at IMPA2 3613 2148 40695_at IMPDH1 3614 2149 36624_at IMPDH2 3615 2150 36598_s_at INPPL1 3636 2151 35303_at INSIG1 3638 2152 38681_at EIF3E 3646 2153 36074_at NA NA 2154 1100_at IRAK1 3654 2155 41266_at ITGA6 3655 2156 669_s_at IRF1 3659 2157 478_g_at IRF5 3663 2158 41049_at IRS1 3667 2159 33304_at ISG20 3669 2160 2061_at ITGA4 3676 2161 1140_at ITGAE 3682 2162 32808_at ITGB1 3688 2163 2019_s_at ITGB7 3695 2164 37201_at ITIH4 3700 2165 35801_at ITPA 3704 2166 37272_at ITPKB 3707 2167 32778_at ITPR1 3708 2168 37343_at ITPR3 3710 2169 34877_at JAK1 3716 2170 34370_at ARCN1 372 2171 34782_at JARID2 3720 2172 32583_at JUN 3725 2173 34898_at AREG 374 2174 34981_at KCNA5 3741 2175 40016_g_at MAST4 375449 2176 36585_at ARF4 378 2177 41106_at KCNN4 3783 2178 41474_at KIF2A 3796 2179 34732_at KIF5B 3799 2180 37984_s_at ARF6 382 2181 32287_s_at NA NA 2182 39057_at KLC1 3831 2183 40407_at KPNA2 3838 2184 35725_at KPNA3 3839 2185 40464_g_at TNPO1 3842 2186 39028_at IPO5 3843 2187 38610_s_at KRT10 3858 2188 37309_at RHOA 387 2189 1395_at RHOC 389 2190 32846_s_at KTN1 3895 2191 37470_at LAIR1 3903 2192 36902_at RHOG 391 2193 232_at LAMC1 3915 2194 39758_f_at LAMP1 3916 2195 553_g_at ARHGAP1 392 2196 38402_at LAMP2 3920 2197 36181_at LASP1 3927 2198 39649_at ARHGAP4 393 2199 288_s_at LBR 3930 2200 37023_at LCP1 3936 2201 39319_at LCP2 3937 2202 41485_at LDHA 3939 2203 39927_at ARHGAP5 394 2204 32855_at LDLR 3949 2205 37754_at LGALS3BP 3959 2206 40164_at ARHGDIA 396 2207 1846_at LGALS8 3964 2208 766_at LGALS9 3965 2209 40155_at ABLIM1 3983 2210 38618_at NA NA 2211 38745_at LIPA 3988 2212 37416_at RHOH 399 2213 34224_at FADS3 3995 2214 36940_at NA NA 2215 37045_at SNX19 399979 2216 33737_f_at NA NA 2217 35974_at LRMP 4033 2218 36493_at LSP1 4046 2219 38081_at LTA4H 4048 2220 40729_s_at LTB 4050 2221 36896_s_at ARNTL 406 2222 38160_at LY75 4065 2223 39971_at LYL1 4066 2224 32616_at LYN 4067 2225 39471_at CAPRIN1 4076 2226 32434_at MARCKS 4082 2227 37280_at SMAD1 4086 2228 1928_s_at SMAD2 4087 2229 36953_at SMAD4 4089 2230 33283_at ARRB2 409 2231 41504_s_at MAF 4094 2232 40036_at MAGOH 4116 2233 39613_at MAN1A1 4121 2234 41766_at MAN2A2 4122 2235 39663_at MAN2A1 4124 2236 32571_at MAT2A 4144 2237 36264_at MATK 4145 2238 34306_at MBNL1 4154 2239 33146_at MCL1 4170 2240 38441_s_at CD46 4179 2241 35799_at DNAJB9 4189 2242 36608_at MDH1 4190 2243 38124_at MDK 4192 2244 837_s_at ME1 4199 2245 36599_at ME2 4200 2246 34355_at MECP2 4204 2247 41747_s_at MEF2A 4205 2248 35434_at MEF2D 4209 2249 35651_at MAP3K4 4216 2250 1327_s_at MAP3K5 4217 2251 35340_at RAB8A 4218 2252 37749_at MEST 4232 2253 36535_at MFAP1 4236 2254 1228_s_at CTAGE5 4253 2255 2052_g_at MGMT 4255 2256 820_at MGST2 4258 2257 39018_at MGST3 4259 2258 41511_at CIITA 4261 2259 41138_at CD99 4267 2260 36938_at ASAH1 427 2261 35937_at MICB 4277 2262 39037_at AFF1 4299 2263 1389_at MME 4311 2264 37283_at MN1 4330 2265 35145_at MNT 4335 2266 37716_at CD200 4345 2267 33284_at MPO 4353 2268 32207_at MPP1 4354 2269 36124_at MPST 4357 2270 34016_s_at ABCC1 4363 2271 36671_at ASNS 440 2272 41129_at TMEM41B 440026 2273 41733_at NA NA 2274 41439_at MYO1B 4430 2275 1719_at MSH3 4437 2276 32317_s_at NA NA 2277 41468_at NA NA 2278 35985_at NA NA 2279 40771_at MSN 4478 2280 39081_at MT2A 4502 2281 38945_at MTF1 4520 2282 35723_at NUDT1 4521 2283 36920_at MTM1 4534 2284 31883_at MTRR 4552 2285 33107_at TRIM37 4591 2286 40105_at MUT 4594 2287 490_g_at MUTYH 4595 2288 37724_at MYC 4609 2289 39738_at MYH9 4627 2290 32838_at MYH10 4628 2291 37114_at ZFHX3 463 2292 32847_at MYLK 4638 2293 40571_at MYO5A 4644 2294 33816_at MYO9B 4650 2295 35362_at MYO10 4651 2296 40438_at PPP1R12A 4659 2297 38692_at NAB1 4664 2298 37717_at HNRNPM 4670 2299 37277_at NAIP 4671 2300 40634_at NAP1L1 4673 2301 32575_at NAP1L4 4676 2302 41241_at NARS 4677 2303 35153_at NBN 4683 2304 41795_at NCK1 4690 2305 32590_at NCL 4691 2306 36169_at NDUFA1 4694 2307 40546_s_at NDUFA2 4695 2308 38462_at NDUFA5 4698 2309 40881_at ACLY 47 2310 35297_at NDUFAB1 4706 2311 38605_at NDUFB1 4707 2312 38981_at NDUFB3 4709 2313 32232_at NDUFB5 4711 2314 32774_at NDUFB8 4714 2315 38485_at NDUFC1 4717 2316 1863_s_at NA NA 2317 38060_at NDUFS5 4725 2318 34865_at NDUFS6 4726 2319 34893_at NDUFV2 4729 2320 40281_at SEPT2 4735 2321 36786_at RPL10A 4736 2322 37907_at NA NA 2323 39143_at NFATC1 4772 2324 40822_at NFATC3 4775 2325 37544_at NFIL3 4783 2326 1461_at NFKBIA 4792 2327 34667_at NFX1 4799 2328 37561_at NFYA 4800 2329 37928_at NFYB 4801 2330 32563_at ATP1B3 483 2331 33415_at NA NA 2332 198_g_at NME3 4832 2333 38999_s_at NMT1 4836 2334 1979_s_at NOP2 4839 2335 38527_at NONO 4841 2336 33861_at CNOT2 4848 2337 32820_at CNOT4 4850 2338 38604_at NPY 4852 2339 430_at PNP 4860 2340 40732_at NPAT 4863 2341 38542_at NPM1 4869 2342 39790_at ATP2A2 488 2343 35320_at SLC11A2 4891 2344 37661_at ATP2B1 490 2345 32340_s_at YBX1 4904 2346 38719_at NSF 4905 2347 31886_at NT5E 4907 2348 38911_at NUP98 4928 2349 40913_at ATP2B4 493 2350 34169_s_at OCRL 4952 2351 1081_at ODC1 4953 2352 38335_at OGG1 4968 2353 39745_at OPA1 4976 2354 40096_at ATP5A1 498 2355 39943_at ORC2L 4999 2356 41142_at OXCT1 5019 2357 33535_at P2RX1 5023 2358 38332_at P2RX4 5025 2359 40396_at P2RX5 5026 2360 691_g_at P4HB 5034 2361 41600_at PA2G4 5036 2362 32611_at PEBP1 5037 2363 35338_at FURIN 5045 2364 32569_at PAFAH1B1 5048 2365 41213_at PRDX1 5052 2366 1558_g_at PAK1 5058 2367 174_s_at ITSN2 50618 2368 34329_at PAK2 5062 2369 37657_at PALM 5064 2370 38465_at PAM 5066 2371 39823_at DCAF8 50717 2372 40621_at PAWR 5074 2373 40115_at ATP5C1 509 2374 32696_at PBX3 5090 2375 34352_at PCBD1 5092 2376 34305_at PCBP1 5093 2377 35745_f_at PCBP2 5094 2378 1348_s_at PCCA 5095 2379 36561_at PCCB 5096 2380 40931_at TMED5 50999 2381 39878_at PCDH9 5101 2382 34359_at HDDC2 51020 2383 39379_at PPPDE1 51029 2384 38667_at GLOD4 51031 2385 37188_at PCK2 5106 2386 41824_at UTP18 51096 2387 37736_at PCMT1 5110 2388 39691_at SH3GLB1 51100 2389 41411_at NDUFAF1 51103 2390 36021_at LEF1 51176 2391 39873_at CDK17 5128 2392 39551_at PHF21A 51317 2393 855_at PDCD2 5134 2394 41646_at TAOK3 51347 2395 36783_f_at ZNF117 51351 2396 37481_at CDC40 51362 2397 39035_at UBR5 51366 2398 37509_at CRLF3 51379 2399 33854_at ATP6V1D 51382 2400 35872_at PDE3B 5140 2401 38712_at C1orf9 51430 2402 35810_at ARPC3 10094 2403 38318_at FAM8A1 51439 2404 39039_s_at UBE2J1 51465 2405 37676_at PDE8A 5151 2406 36934_at C20orf111 51526 2407 35325_at RAB14 51552 2408 34825_at TTRAP 51567 2409 35215_at LARP7 51574 2410 39576_at PDE6B 5158 2411 33368_at AZIN1 51582 2412 41665_at PCF11 51585 2413 32635_at TRIM33 51592 2414 31896_at NBAS 51594 2415 38324_at LSR 51599 2416 32262_at METTL13 51603 2417 39160_at PDHB 5162 2418 37199_at DYNC2LI1 51626 2419 40610_at ZFR 51663 2420 36975_at TMEM66 51669 2421 41123_s_at ENPP2 5168 2422 36846_s_at LSM7 51690 2423 35408_i_at ZNF44 51710 2424 34397_at LUC7L3 51747 2425 37398_at PECAM1 5175 2426 33870_at KDM3B 51780 2427 36829_at PER1 5187 2428 38365_at PEX1 5189 2429 37143_s_at PFAS 5198 2430 41003_at PFDN4 5203 2431 38751_i_at ATP5I 521 2432 36196_at PFKM 5213 2433 39175_at PFKP 5214 2434 36675_r_at PFN1 5216 2435 36107_at ATP5J 522 2436 41221_at PGAM1 5223 2437 36963_at PGD 5226 2438 34889_at ATP6V1A 523 2439 31488_s_at PGK1 5230 2440 32210_at PGM1 5236 2441 1575_at ABCB1 5243 2442 33978_at ABCB4 5244 2443 37675_at SLC25A3 5250 2444 40446_at PHF1 5252 2445 39117_at PHF2 5253 2446 36480_at PHKA2 5256 2447 37392_at PHKB 5257 2448 40568_at ATP6V1B2 526 2449 34789_at SERPINB6 5269 2450 36994_at ATP6V0C 527 2451 39993_at PIGA 5277 2452 40629_at PIGH 5283 2453 41715_at PIK3C2B 5287 2454 1779_s_at PIM1 5292 2455 36287_at PIK3CG 5294 2456 40783_s_at NA NA 2457 38120_at PKD2 5311 2458 32378_at PKM2 5315 2459 36943_r_at PLAGL1 5325 2460 40061_at PLAGL2 5326 2461 37310_at PLAU 5328 2462 36167_at ATP6V0B 533 2463 41356_at BCL11A 53335 2464 37180_at PLCG2 5336 2465 37328_at PLEK 5341 2466 41048_at PMAIP1 5366 2467 35770_at ATP6AP1 537 2468 31600_s_at NA NA 2469 37029_at ATP5O 539 2470 38702_at POLE3 54107 2471 33543_s_at PNN 5411 2472 40839_at UBL3 5412 2473 38372_at NA NA 2474 40451_at POLE 5426 2475 33726_at POLR2D 5433 2476 39747_at POLR2G 5436 2477 34828_at POLR2I 5438 2478 40296_at SASH3 54440 2479 40504_at PON2 5445 2480 36550_at RIN2 54453 2481 40308_at ATAD2B 54454 2482 37917_at MIOS 54468 2483 37229_at ATR 545 2484 36239_at POU2AF1 5450 2485 39140_at DHX29 54505 2486 40896_at POU2F1 5451 2487 35165_at CCDC93 54520 2488 31808_at ING3 54556 2489 35940_at POU4F1 5457 2490 39147_g_at ATRX 546 2491 38778_at OTUD4 54726 2492 33829_at LEPROT 54741 2493 39062_at CTSA 5476 2494 33667_at PPIA 5478 2495 35823_at PPIB 5479 2496 948_s_at PPID 5481 2497 38652_at C10orf26 54838 2498 34739_at FNBP1L 54874 2499 37616_at AUH 549 2500 857_at PPM1A 5494 2501 35727_at UCKL1 54963 2502 32157_at PPP1CA 5499 2503 33683_at TUG1 55000 2504 37725_at PPP1CC 5501 2505 33180_at PPP1R2 5504 2506 41253_s_at PLEKHB2 55041 2507 35067_at AGGF1 55109 2508 33125_at FANCL 55120 2509 237_s_at PPP2CA 5515 2510 924_s_at PPP2CB 5516 2511 32954_at RIF1 55183 2512 34804_at SLC25A36 55186 2513 32743_at VPS13D 55187 2514 39127_f_at PPP2R4 5524 2515 32187_at PCMTD2 55251 2516 40786_at PPP2R5C 5527 2517 39401_at LOC552889 552889 2518 32734_at PPP2R5E 5529 2519 41732_at BOLA2 552900 2520 33394_at DDX19A 55308 2521 35709_at RFK 55312 2522 39780_at PPP3CB 5532 2523 41188_at LAPTM4B 55353 2524 34774_at PPT1 5538 2525 37950_at PREP 5550 2526 33264_at ENOSF1 55556 2527 40618_at CDV3 55573 2528 41015_at PRKAA1 5562 2529 40868_at THUMPD1 55623 2530 39129_at NA NA 2531 35154_at BTBD2 55643 2532 41322_s_at NHP2 55651 2533 38899_s_at MFN1 55669 2534 36215_at PRKACB 5567 2535 36647_at IARS2 55699 2536 33192_g_at FAM178A 55719 2537 41768_at PRKAR1A 5573 2538 33173_g_at SEPT11 55752 2539 37221_at PRKAR2B 5577 2540 160029_at PRKCB 5579 2541 32046_at PRKCD 5580 2542 41649_at FOXJ2 55810 2543 34786_at KDM3A 55818 2544 1267_at PRKCH 5583 2545 33126_at GLT8D1 55830 2546 37315_f_at EAPP 55837 2547 41579_s_at PRKCI 5584 2548 35750_at ZC3H15 55854 2549 40167_s_at WSB2 55884 2550 38670_at RNF114 55905 2551 40129_at PRKDC 5591 2552 35136_at NXT2 55916 2553 37501_at NKRF 55922 2554 38674_at KLHL9 55958 2555 36926_at MAPK6 5597 2556 38431_at MAPK9 5601 2557 1130_at MAP2K1 5604 2558 1698_g_at MAP2K5 5607 2559 41141_at PRKRIR 5612 2560 40030_at PRKY 5616 2561 36159_s_at PRNP 5621 2562 35572_f_at ZNF253 56242 2563 38837_at TMX4 56255 2564 40916_at BEX4 56271 2565 40973_at PARD3 56288 2566 41490_at PRPS2 5634 2567 41853_at PRPSAP2 5636 2568 317_at LGMN 5641 2569 36795_at PSAP 5660 2570 39323_at INPP5E 56623 2571 641_at PSEN1 5663 2572 38690_at CLDND1 56650 2573 201_s_at B2M 567 2574 35682_at ZC3HAV1 56829 2575 1446_at PSMA2 5683 2576 1448_at PSMA3 5684 2577 1450_g_at PSMA4 5685 2578 37046_at PSMA5 5686 2579 36122_at PSMA6 5687 2580 1447_at PSMB1 5689 2581 1310_at PSMB2 5690 2582 1309_at PSMB3 5691 2583 41295_at STARD7 56910 2584 33154_at PSMB4 5692 2585 37666_at PSMB5 5693 2586 941_at PSMB6 5694 2587 38989_at C3orf37 56941 2588 39517_at C5orf15 56951 2589 41184_s_at PSMB8 5696 2590 38287_at PSMB9 5698 2591 31867_at BBX 56987 2592 384_at PSMB10 5699 2593 688_at PSMC1 5700 2594 35353_at PSMC2 5701 2595 38072_at C1orf63 57035 2596 31852_at ANKMY2 57037 2597 37766_s_at PSMC5 5705 2598 33150_at UTP3 57050 2599 949_s_at PSMC6 5706 2600 1314_at PSMD1 5707 2601 31895_at BACH1 571 2602 40276_at PSMD7 5713 2603 1312_at PSMD8 5714 2604 31536_at RTN4 57142 2605 41329_at SCYL3 57147 2606 41488_at LYRM1 57149 2607 37350_at PSMD10 5716 2608 1191_s_at PSMD11 5717 2609 35848_at ZMIZ1 57178 2610 1192_at PSMD12 5718 2611 36600_at PSME1 5720 2612 40853_at ATP10D 57205 2613 41171_at PSME2 5721 2614 33123_at THAP11 57215 2615 34176_at SMAGP 57228 2616 36736_f_at PSPH 5723 2617 34902_at NA NA 2618 40593_at PTBP1 5725 2619 39552_at PTEN 5728 2620 34798_at BAG1 573 2621 828_at PTGER2 5732 2622 38063_at PBXIP1 57326 2623 1118_at PTGER4 5734 2624 33716_at RAB22A 57403 2625 33358_at PPM1H 57460 2626 41559_at GRAMD1B 57476 2627 33328_at HEG1 57493 2628 39163_at KIDINS220 57498 2629 36275_at SEMA6A 57556 2630 1064_at TWF1 5756 2631 38589_i_at PTMA 5757 2632 40980_at CHD8 57680 2633 40137_at PTPN1 5770 2634 37893_at PTPN2 5771 2635 37308_at GPR107 57720 2636 1460_g_at PTPN4 5775 2637 1760_s_at PTPN7 5778 2638 38397_at POLD4 57804 2639 38443_at PTPN11 5781 2640 41375_at LSM2 57819 2641 31402_at HMHB1 57824 2642 40519_at PTPRC 5788 2643 33911_at PTPRD 5789 2644 995_g_at PTPRM 5797 2645 36160_s_at PTPRN2 5799 2646 1801_at BARD1 580 2647 35697_at PTS 5805 2648 35221_at PURA 5813 2649 32156_at PVRL2 5819 2650 34059_at PVT1 5820 2651 40471_at PEX19 5824 2652 37038_at ABCD3 5825 2653 37215_at PYGL 5836 2654 41495_at CREBZF 58487 2655 32963_s_at RRAGD 58528 2656 1074_at RAB1A 5861 2657 40521_at RGL2 5863 2658 35304_at RAB6A 5870 2659 781_at RABGGTB 5876 2660 38264_at RABIF 5877 2661 38114_at RAD21 5885 2662 1874_at RAD23B 5887 2663 1077_at RAG1 5896 2664 578_at RAG2 5897 2665 32776_at RALB 5899 2666 32755_at ACTA2 59 2667 38708_at RAN 5901 2668 41342_at RANBP1 5902 2669 32788_at RANBP2 5903 2670 1848_at RAP1A 5906 2671 40146_at RAP1B 5908 2672 32602_at RAP1GDS1 5910 2673 549_at RARS 5917 2674 33236_at RARRES3 5920 2675 1675_at RASA1 5921 2676 2044_s_at RB1 5925 2677 38265_at RBBP6 5930 2678 32597_at RBL2 5934 2679 35351_at RBM4 5936 2680 33867_s_at RBMS1 5937 2681 41683_i_at BCKDHB 594 2682 37727_i_at RCN2 5955 2683 1909_at BCL2 596 2684 34887_at RDX 5962 2685 34684_at RECQL 5965 2686 1295_at RELA 5970 2687 39404_s_at UPF1 5976 2688 38908_s_at REV3L 5980 2689 32144_at RFX5 5993 2690 36575_at RGS1 5996 2691 37701_at RGS2 5997 2692 41779_at RGS16 6004 2693 1659_s_at RHEB 6009 2694 38331_at RIT1 6016 2695 41852_at RLF 6018 2696 34660_at RNASE6 6039 2697 40091_at BCL6 604 2698 38311_at TGIF2 60436 2699 33484_at RNF2 6045 2700 33821_at ELOVL5 60481 2701 35761_at AASDHPPT 60496 2702 32842_at BCL7A 605 2703 36187_at RNH1 6050 2704 36959_at RNPEP 6051 2705 39355_at ABCE1 6059 2706 38164_at RPGR 6103 2707 1119_at RPA2 6118 2708 33485_at RPL4 6124 2709 33661_at NA NA 2710 31505_at RPL8 6132 2711 36358_at RPL9 6133 2712 33668_at RPL12 6136 2713 31546_at RPL18 6141 2714 33451_s_at RPL22 6146 2715 39856_at RPL36AL 6166 2716 41152_f_at RPL36A 6173 2717 33424_at RPN1 6184 2718 36676_at RPN2 6185 2719 41214_at RPS4Y1 6192 2720 32437_at RPS5 6193 2721 35125_at RPS6 6194 2722 1127_at RPS6KA1 6195 2723 33325_at RPS6KA2 6196 2724 33229_at RPS6KA3 6197 2725 31511_at RPS9 6203 2726 33117_r_at RPS12 6206 2727 39916_r_at RPS15 6209 2728 34316_at RPS15A 6210 2729 31330_at RPS19 6223 2730 32315_at RPS24 6229 2731 34350_at CLIP1 6249 2732 539_at RYK 6259 2733 33280_r_at ACSM3 6296 2734 36083_at TSPAN31 6302 2735 34304_s_at SAT1 6303 2736 36899_at SATB1 6304 2737 39835_at SBF1 6305 2738 33421_s_at SC5DL 6309 2739 36142_at ATXN1 6310 2740 36998_s_at ATXN2 6311 2741 37147_at CLEC11A 6320 2742 36688_at SCP2 6342 2743 36103_at CCL3 6348 2744 36674_at CCL4 6351 2745 32725_at BID 637 2746 38110_at SDCBP 6386 2747 34826_at SDHA 6389 2748 34385_at SDHC 6391 2749 40467_at SDHD 6392 2750 39049_at GPSM3 63940 2751 33423_g_at SEC13 6396 2752 245_at SELL 6402 2753 1544_at BLM 641 2754 34767_at MOAP1 64112 2755 40456_at SLC39A8 64116 2756 34283_at XYLT1 64131 2757 36910_at MAP2K4 6416 2758 40189_at SET 6418 2759 37700_at BLMH 642 2760 36223_at SFPQ 6421 2761 36098_at SFRS1 6426 2762 36112_r_at SFRS2 6427 2763 36991_at SFRS4 6429 2764 40453_s_at SFRS5 6430 2765 35809_g_at SFRS6 6431 2766 32165_at SFRS7 6432 2767 31909_at KIAA0754 643314 2768 140_s_at TRA2B 6434 2769 41077_at ZNF862 643641 2770 32618_at BLVRA 644 2771 39714_at SH3BGRL 6451 2772 1303_at SH3BP2 6452 2773 36321_at TTTY15 64595 2774 38118_at SHC1 6464 2775 33354_at SMURF2 64750 2776 39692_at CREB3L2 64764 2777 32160_at SIAH1 6477 2778 33799_at SIAH2 6478 2779 36580_at RMND5A 64795 2780 41562_at BMI1 648 2781 41352_at ST6GAL1 6480 2782 35268_at MARCH7 64844 2783 41398_at YTHDC2 64848 2784 32767_at STIL 6491 2785 36843_at SIPA1 6494 2786 40367_at BMP2 650 2787 2010_at SKP1 6500 2788 1427_g_at SLA 6503 2789 33513_at SLAMF1 6504 2790 41126_at SLC1A4 6509 2791 38105_at RSRC2 65117 2792 38029_at SLC3A2 6520 2793 41249_at NADK 65220 2794 40244_s_at MPPE1 65258 2795 40813_at SLC5A3 6526 2796 38440_s_at NA NA 2797 39748_at SLC7A1 6541 2798 1138_at SLC20A1 6574 2799 38997_at SLC25A1 6576 2800 40961_at SMARCA2 6595 2801 34327_at HLTF 6596 2802 32579_at SMARCA4 6597 2803 452_at SMARCC1 6599 2804 36692_at MTMR9 66036 2805 38738_at SUMO3 6612 2806 35488_at SNAPC1 6617 2807 39070_at FSCN1 6624 2808 40842_at SNRPA 6626 2809 38455_at SNRPB 6628 2810 38399_at SNRPB2 6629 2811 32060_at BNIP2 663 2812 35270_at SNRPD2 6633 2813 40150_at SNRPD3 6634 2814 38678_at SNRPE 6635 2815 41403_at SNRPF 6636 2816 37337_at SNRPG 6637 2817 34842_at NA NA 2818 38010_at BNIP3 664 2819 36583_at SNX1 6642 2820 40589_at SNTB2 6645 2821 36620_at SOD1 6647 2822 34666_at SOD2 6648 2823 39097_at SON 6651 2824 38411_at SORL1 6653 2825 33260_at SOS1 6654 2826 32857_at SOS2 6655 2827 41573_at SP3 6670 2828 671_at SPARC 6678 2829 35171_at SPAST 6683 2830 31673_s_at SPG7 6687 2831 41071_at SPINK2 6691 2832 36798_g_at SPN 6693 2833 38906_at SPTA1 6708 2834 33833_at SPTAN1 6709 2835 39452_s_at SPTBN1 6711 2836 589_at SRD5A1 6715 2837 39055_at SRI 6717 2838 40109_at SRF 6722 2839 36981_at SRP9 6726 2840 36060_at SRP54 6729 2841 33837_at SRP72 6731 2842 1031_at SRPK1 6732 2843 1213_at SRPK2 6733 2844 35294_at TROVE2 6738 2845 38409_at SSFA2 6744 2846 34649_at SSR1 6745 2847 38635_at SSR4 6748 2848 1503_at BRCA2 675 2849 31872_at SS18 6760 2850 1640_at ST13 6767 2851 38740_at ZFP36L1 677 2852 39708_at STAT3 6774 2853 906_at STAT4 6775 2854 506_s_at STAT5A 6776 2855 33869_at STAT5B 6777 2856 41222_at STAT6 6778 2857 32588_s_at ZFP36L2 678 2858 41823_at STAU1 6780 2859 38676_at HSPA13 6782 2860 665_at NEK4 6787 2861 32142_at STK3 6788 2862 40420_at STK10 6793 2863 37962_r_at STXBP3 6814 2864 31804_f_at SULT1A1 6817 2865 32675_at BST1 683 2866 41408_at SUPV3L1 6832 2867 35646_at NA NA 2868 39061_at BST2 684 2869 34753_at VAMP7 6845 2870 38075_at SYPL1 6856 2871 40841_at TACC1 6867 2872 37770_at TAF2 6873 2873 142_at TAF4 6874 2874 192_at TAF7 6879 2875 193_at TAF9 6880 2876 868_at TAF10 6881 2877 38426_at TAF11 6882 2878 36905_at MAP3K7 6885 2879 31932_f_at BTF3 689 2880 41168_at TAPBP 6892 2881 39779_at TARBP1 6894 2882 38473_at TARS 6897 2883 34773_at TBCA 6902 2884 36176_at TBCC 6903 2885 39398_s_at TBCD 6904 2886 35159_at TBCE 6905 2887 32554_s_at TBL1X 6907 2888 336_at TBXA2R 6915 2889 33777_at TBXAS1 6916 2890 1073_at TCEA1 6917 2891 1399_at TCEB1 6921 2892 36605_at TCF4 6925 2893 1373_at TCF3 6929 2894 32025_at TCF7L2 6934 2895 33440_at ZEB1 6935 2896 33315_at C2orf3 6936 2897 37294_at BTG1 694 2898 37106_at ZNF354A 6940 2899 33873_at VPS72 6944 2900 38213_at BTK 695 2901 34791_at TCP1 6950 2902 36921_at DYNLT3 6990 2903 38412_at PPP1R11 6992 2904 40865_at TDG 6996 2905 32255_i_at NA NA 2906 40084_at TFCP2 7024 2907 37757_at TFDP1 7027 2908 40767_at TFPI 7035 2909 37324_at TFRC 7037 2910 1830_s_at TGFB1 7040 2911 38374_at KLF10 7071 2912 33852_at TIA1 7072 2913 41762_at TIAL1 7073 2914 38370_at TIAM1 7074 2915 37668_at C1QBP 708 2916 38789_at TKT 7086 2917 38364_at TLE4 7091 2918 32166_at TLN1 7094 2919 950_at SEC62 7095 2920 40310_at TLR2 7097 2921 39775_at SERPING1 710 2922 38408_at TSPAN7 7102 2923 38303_at TRAPPC10 7109 2924 31801_at TMF1 7110 2925 32683_at TMPO 7112 2926 31557_at TMSB4X 7114 2927 1852_at TNF 7124 2928 38631_at TNFAIP2 7127 2929 595_at TNFAIP3 7128 2930 1583_at TNFRSF1B 7133 2931 31680_at TOP1P2 7152 2932 1581_s_at TOP2B 7155 2933 1939_at TP53 7157 2934 34822_at TP53BP2 7159 2935 368_at TPBG 7162 2936 40076_at TPD52L2 7165 2937 32314_g_at TPM2 7169 2938 33866_at TPM4 7171 2939 41459_at TPP2 7174 2940 31584_at TPT1 7178 2941 603_at NR2C1 7181 2942 442_at HSP90B1 7184 2943 35238_at TRAF5 7188 2944 32323_at TRH 7200 2945 41051_at TSNAX 7257 2946 36123_at TST 7263 2947 37321_at TTC1 7265 2948 39065_s_at TTC3 7267 2949 36478_at TTF1 7270 2950 40795_at TTN 7273 2951 41174_at NA NA 2952 39867_at TUFM 7284 2953 33301_g_at CDK11A 728642 2954 41243_at NA NA 2955 34841_at NA NA 2956 32319_at TNFSF4 7292 2957 39425_at TXNRD1 7296 2958 34530_at LOC729678 729678 2959 993_at TYK2 7297 2960 2086_s_at TYRO3 7301 2961 40553_at LOC729400 729400 2962 36517_at U2AF1 7307 2963 1367_f_at UBC 7316 2964 1294_at UBA7 7318 2965 38705_at UBE2D2 7322 2966 37358_at UBE2E1 7324 2967 32236_at UBE2G2 7327 2968 33136_at UBE2I 7329 2969 223_at UBE2L3 7332 2970 1660_at UBE2N 7334 2971 41205_at UBE3A 7337 2972 457_s_at SUMO1 7341 2973 38794_at UBTF 7343 2974 37591_at UCP2 7351 2975 811_at UFD1L 7353 2976 40215_at UGCG 7357 2977 37373_at UGP2 7360 2978 37193_at UCK2 7371 2979 33815_at UMPS 7372 2980 39427_at UQCRB 7381 2981 40854_at UQCRC2 7385 2982 34401_at UQCRFS1 7386 2983 36104_at UQCRH 7388 2984 37667_at UROD 7389 2985 34477_at UTY 7404 2986 39429_at UVRAG 7405 2987 171_at VBP1 7411 2988 36601_at VCL 7414 2989 40198_at VDAC1 7416 2990 37696_at VDAC2 7417 2991 36100_at VEGFA 7422 2992 37268_at VEGFB 7423 2993 34091_s_at VIM 7431 2994 36873_at VLDLR 7436 2995 39980_at VRK1 7443 2996 41212_r_at EIF4H 7458 2997 41396_at CLIP2 7461 2998 36909_at WEE1 7465 2999 35164_at WFS1 7466 3000 32777_at WRB 7485 3001 1500_at WT1 7490 3002 38446_at XIST 7503 3003 1307_at XPA 7507 3004 1873_at XPC 7508 3005 37100_at FMNL1 752 3006 585_at XRCC5 7520 3007 1674_at YES1 7525 3008 891_at YY1 7528 3009 32324_at YWHAB 7529 3010 40046_r_at C18orf1 753 3011 1011_s_at YWHAE 7531 3012 1424_s_at YWHAH 7533 3013 39003_at PTTG1IP 754 3014 32075_at ZFP161 7541 3015 38931_at ZFX 7543 3016 31534_at ZFY 7544 3017 32841_at CNBP 7555 3018 35413_s_at ZNF22 7570 3019 32809_at ZNF24 7572 3020 41713_at ZKSCAN1 7586 3021 40569_at MZF1 7593 3022 33982_f_at ZNF43 7594 3023 41033_at ZNF84 7637 3024 932_i_at ZNF91 7644 3025 35051_at CA6 765 3026 37264_at ZNF131 7690 3027 36295_at ZNF134 7693 3028 36392_at ZNF135 7694 3029 38603_at ZNF136 7695 3030 39681_at ZBTB16 7704 3031 36928_at ZNF146 7705 3032 32628_at VEZF1 7716 3033 33572_at ZNF165 7718 3034 37500_at ZNF175 7728 3035 35475_at ZNF177 7730 3036 36565_at RNF113A 7737 3037 32086_at ZNF184 7738 3038 32139_at ZNF185 7739 3039 35368_at ZNF207 7756 3040 41542_at ZFAND5 7763 3041 32034_at ZNF217 7764 3042 39719_at NA NA 3043 36958_at ZYX 7791 3044 843_at PTP4A1 7803 3045 36634_at BTG2 7832 3046 39327_at PXDN 7837 3047 34726_at CACNB3 784 3048 38344_at ALMS1 7840 3049 1637_at MAPKAPK3 7867 3050 37672_at USP7 7874 3051 1252_at REEP5 7905 3052 37794_at ZNF783 155060 3053 38992_at DEK 7913 3054 181_g_at MBOAT7 79143 3055 41790_at ALDH5A1 7915 3056 33913_at BAT2 7916 3057 35292_at BAT1 7919 3058 37967_at LST1 7940 3059 34482_at HAUS3 79441 3060 34857_at ATP13A3 79572 3061 39045_at ADIPOR2 79602 3062 41250_at AIMP2 7965 3063 35858_at NA NA 3064 38744_at SHFM1 7979 3065 40859_at ZC3H14 79882 3066 41177_at LPCAT1 79888 3067 34685_at PYROXD1 79912 3068 32251_at TCEAL4 79921 3069 840_at MYST3 7994 3070 39650_s_at PCNXL2 80003 3071 41143_at CALM1 801 3072 41841_at BRD3 8019 3073 41381_at CHD9 80205 3074 160_at STAM 8027 3075 37162_at CCDC6 8030 3076 32248_at WDR82 80335 3077 36127_g_at COASY 80347 3078 911_s_at NA NA 3079 38415_at PTP4A2 8073 3080 1158_s_at CALM3 808 3081 41535_at CDK2AP1 8099 3082 41753_at ACTN4 81 3083 39050_at PABPN1 8106 3084 37034_at ANP32A 8125 3085 37345_at CALU 813 3086 32186_at SLC7A5 8140 3087 32768_at TDRD3 81550 3088 34830_at VOPP1 81552 3089 34413_at NDEL1 81565 3090 32217_at CSRNP2 81566 3091 40347_at ANP32E 81611 3092 38641_at TSC22D4 81628 3093 39370_at MAP1LC3B 81631 3094 37698_at AKAP1 8165 3095 40613_at C6orf62 81688 3096 41147_at ISCA1 81689 3097 34140_at C15orf5 81698 3098 37462_i_at SF3A2 8175 3099 39388_at CAMK2G 818 3100 40127_at SFXN3 81855 3101 40946_at ISG20L2 81875 3102 33381_at NCOA3 8202 3103 40088_at NRIP1 8204 3104 40125_at CANX 821 3105 38391_at CAPG 822 3106 33908_at CAPN1 823 3107 37001_at CAPN2 824 3108 32849_at SMC1A 8243 3109 36138_at CAPNS1 826 3110 37583_at KDM5D 8284 3111 35885_at USP9Y 8287 3112 40910_at CAPZA1 829 3113 33810_at TRRAP 8295 3114 36641_at CAPZA2 830 3115 41512_at BRAP 8315 3116 37012_at CAPZB 832 3117 34472_at FZD6 8323 3118 34308_at HIST1H2AC 8334 3119 574_s_at CASP1 834 3120 33352_at HIST2H2BE 8349 3121 36143_at CASP3 836 3122 39969_at HIST1H4C 8364 3123 195_s_at CASP4 837 3124 32161_at LONP2 83752 3125 35662_at CASP6 839 3126 37253_at PIP5K1B 8395 3127 38281_at CASP7 840 3128 39423_f_at SPOP 8405 3129 36678_at TAGLN2 8407 3130 33774_at CASP8 841 3131 36814_at KIAA1109 84162 3132 38774_at STX7 8417 3133 39317_at CMAH 8418 3134 33915_at SETD3 84193 3135 487_g_at CASP9 842 3136 40473_at STK24 8428 3137 39999_at CASP10 843 3138 35236_g_at RECK 8434 3139 37673_at NSMAF 8439 3140 33003_at NCK2 8440 3141 39392_at GNPAT 8443 3142 39931_at DYRK3 8444 3143 760_at DYRK2 8445 3144 39896_at DHX16 8449 3145 40141_at CUL4B 8450 3146 39698_at HOPX 84525 3147 35172_at TPST2 8459 3148 32718_at TPST1 8460 3149 38182_at CYorf15B 84663 3150 39132_at SMARCA5 8467 3151 37009_at CAT 847 3152 38724_at BAT2L1 84726 3153 39507_at OGT 8473 3154 35764_at OFD1 8481 3155 36987_at LMNB2 84823 3156 38864_at NFATC2IP 84901 3157 37107_at PPM1D 8493 3158 37577_at ARHGAP19 84986 3159 41780_at PPFIA1 8500 3160 38270_at PARG 8505 3161 31901_at KCNAB2 8514 3162 34344_at IKBKAP 8518 3163 675_at IFITM1 8519 3164 41855_at HAT1 8520 3165 33387_at GAS7 8522 3166 31992_f_at HIST1H2AH 85235 3167 35349_at COPS3 8533 3168 39225_at AGPS 8540 3169 1452_at LMO4 8543 3170 39562_at CGGBP1 8545 3171 41506_at MAPKAPK5 8550 3172 40790_at BHLHE40 8553 3173 33337_at DEGS1 8560 3174 38977_at YARS 8565 3175 35714_at PDXK 8566 3176 35299_at MKNK1 8569 3177 38828_s_at KHSRP 8570 3178 31854_at CASK 8573 3179 32205_at PRKRA 8575 3180 40034_r_at SCARF1 8578 3181 41278_at ACTL6A 86 3182 943_at RUNX1 861 3183 41821_at CDK13 8621 3184 37249_at PDE8B 8622 3185 36554_at ASMTL 8623 3186 36088_at PSMG1 8624 3187 41442_at CBFA2T3 863 3188 106_at RUNX3 864 3189 37399_at AKR1C3 8644 3190 484_at NCOA1 8648 3191 41175_at CBFB 865 3192 41592_at SOCS1 8651 3193 38355_at DDX3Y 8653 3194 39430_at TNKS 8658 3195 35323_at EIF3B 8662 3196 35298_at EIF3D 8664 3197 32576_at EIF3F 8665 3198 35327_at EIF3H 8667 3199 32230_at EIF3I 8668 3200 33907_at EIF4G3 8672 3201 32715_at VAMP8 8673 3202 36818_at VAMP4 8674 3203 39378_at BECN1 8678 3204 32573_at SFRS9 8683 3205 35074_at JRKL 8690 3206 31877_at CDC23 8697 3207 33602_at S1PR4 8698 3208 39329_at ACTN1 87 3209 34177_at B4GALT2 8704 3210 41189_at TNFRSF25 8718 3211 40605_at SNX4 8723 3212 39360_at SNX3 8724 3213 38011_at C19orf2 8725 3214 31853_at EED 8726 3215 35331_at CTNNAL1 8727 3216 36035_at GPAA1 8733 3217 1211_s_at CRADD 8738 3218 34761_r_at ADAM9 8754 3219 41343_at CDS2 8760 3220 40506_s_at PABPC4 8761 3221 34819_at CD164 8763 3222 39424_at TNFRSF14 8764 3223 36660_at RAB11A 8766 3224 41384_at RIPK2 8767 3225 32178_r_at SNAP23 8773 3226 34654_at MTMR1 8776 3227 37209_g_at NA NA 3228 34892_at TNFRSF10B 8795 3229 37900_at PEX11B 8799 3230 40893_at SUCLA2 8803 3231 35311_at CREG1 8804 3232 34879_at DPM1 8813 3233 40992_s_at SAP30 8819 3234 1825_at IQGAP1 8826 3235 36457_at GMPS 8833 3236 37263_at GGH 8836 3237 41470_at PROM1 8842 3238 39032_at TSC22D1 8848 3239 39410_at ASAP2 8853 3240 34256_at ST3GAL5 8869 3241 1237_at IER3 8870 3242 36532_at SYNJ2 8871 3243 34498_at VNN2 8875 3244 33373_at FUBP1 8880 3245 32518_at ZNF259 8882 3246 35364_at NAE1 8883 3247 35279_at TAX1BP1 8887 3248 40469_at MCM3AP 8888 3249 34031_i_at KRIT1 889 3250 40515_at EIF2B2 8892 3251 39706_at CPNE3 8895 3252 39029_at BUD31 8896 3253 32784_at PRPF4B 8899 3254 40452_at CPNE1 8904 3255 41549_s_at AP1S2 8905 3256 38798_s_at AP1G2 8906 3257 34386_at MBD4 8930 3258 33905_at MBD2 8932 3259 33856_at FAM127A 8933 3260 36091_at SKAP2 8935 3261 37190_at WASF1 8936 3262 31879_at FUBP3 8939 3263 36650_at CCND2 894 3264 36172_s_at AP3D1 8943 3265 1794_at CCND3 896 3266 35562_at HIST1H2BJ 8970 3267 34390_at P4HA2 8974 3268 40701_at USP13 8975 3269 40623_at UBE3B 89910 3270 33875_at ATP6V0E1 8992 3271 39764_at ACVR1 90 3272 1920_s_at CCNG1 900 3273 1913_at CCNG2 901 3274 32261_at BAZ1B 9031 3275 33466_at C5orf30 90355 3276 40066_at UBA3 9039 3277 38727_at MCFD2 90411 3278 32053_at CCNT2 905 3279 39533_at SLC7A6 9057 3280 1527_s_at N4BP2L1 90634 3281 35804_at ASH2L 9070 3282 38416_at CCT6A 908 3283 40097_at EIF1AY 9086 3284 33999_f_at LOC90925 90925 3285 36982_at USP14 9097 3286 31526_f_at USP6 9098 3287 36451_at ACVR1B 91 3288 37683_at USP10 9100 3289 37835_at CD1C 911 3290 39707_at MTMR4 9110 3291 36472_at NMI 9111 3292 1643_g_at MTA1 9112 3293 37178_at SLC25A46 91137 3294 33143_s_at SLC16A3 9123 3295 36937_s_at PDLIM1 9124 3296 34763_at SMC3 9126 3297 37936_at PRPF4 9128 3298 39053_at PRPF3 9129 3299 32212_at AIFM1 9131 3300 41827_f_at LOC91316 91316 3301 35249_at CCNE2 9134 3302 810_at ARHGEF1 9138 3303 35354_at SYNGR1 9145 3304 35979_at CTDP1 9150 3305 34361_at PCSK7 9159 3306 38910_at ATPAF2 91647 3307 34330_at COX7A2L 9167 3308 31481_s_at TMSB10 9168 3309 35258_f_at SFRS2IP 9169 3310 40099_at ARHGEF2 9181 3311 41547_at BUB3 9184 3312 37630_at CHRDL1 91851 3313 39168_at ZBED1 9189 3314 39762_at ZMYM4 9202 3315 32967_at FAIM3 9214 3316 41346_at LARGE 9215 3317 33206_at MTSS1L 92154 3318 38801_at VAPA 9218 3319 36597_at NOLC1 9221 3320 40575_at DLG5 9231 3321 771_s_at CD7 924 3322 40782_at DHRS3 9249 3323 39734_at AIMP1 9255 3324 34460_at BZRAP1 9256 3325 37524_at STK17B 9262 3326 38823_s_at STK17A 9263 3327 40426_at BCL7B 9275 3328 36677_at COPB2 9276 3329 38275_at IMP4 92856 3330 35769_at GPR56 9289 3331 32183_at SFRS11 9295 3332 37536_at CD83 9308 3333 41860_at C13orf27 93081 3334 40749_at MS4A1 931 3335 36214_at KLF4 9314 3336 34323_at COPS2 9318 3337 39699_at TRIP12 9320 3338 41251_at ZNHIT3 9326 3339 41360_at CNOT8 9337 3340 35783_at VAMP3 9341 3341 38093_at MAPK1IP1L 93487 3342 32394_s_at RPL23 9349 3343 32214_at TXNL1 9352 3344 36579_at UBE4A 9354 3345 40681_at ITGBL1 9358 3346 37385_at PPIG 9360 3347 32174_at SLC9A3R1 9368 3348 34307_at TM9SF2 9375 3349 41223_at COX5A 9377 3350 40133_s_at GRHPR 9380 3351 38578_at CD27 939 3352 41656_at NMT2 9397 3353 38820_at SEP15 9403 3354 36403_s_at ZNF101 94039 3355 36062_at LPXN 9404 3356 41370_at SNRNP40 9410 3357 36849_at ARHGAP29 9411 3358 39923_at ARHGAP12 94134 3359 36655_at TJP2 9414 3360 40465_at DDX23 9416 3361 39046_at H2AFV 94239 3362 32111_at CDYL 9425 3363 39759_at QKI 9444 3364 41300_s_at ITM2B 9445 3365 824_at GSTO1 9446 3366 35694_at MAP4K4 9448 3367 36802_at CD33 945 3368 35869_at LY86 9450 3369 35296_at GGPS1 9453 3370 37543_at ARHGEF6 9459 3371 38968_at SH3BP5 9467 3372 38747_at CD34 947 3373 35335_at ROCK2 9475 3374 41200_at SCARB1 949 3375 36974_at PSMF1 9491 3376 34936_at SLC4A7 9497 3377 41139_at MAGED1 9500 3378 31870_at CD37 951 3379 37024_at LITAF 9516 3380 31797_at TBPL1 9519 3381 40323_at CD38 952 3382 39431_at NPEPPS 9520 3383 40587_s_at EEF1E1 9521 3384 40725_at GOSR1 9527 3385 39033_at TMEM59 9528 3386 36463_at BAG5 9529 3387 35019_at ZNF254 9534 3388 35261_at GMFG 9535 3389 38097_at EI24 9538 3390 38814_at ATP6V1G1 9550 3391 38817_at SPAG7 9552 3392 39717_g_at MRPL33 9553 3393 41597_s_at SEC22B 9554 3394 36576_at H2AFY 9555 3395 38967_at C14orf2 9556 3396 35790_at VPS26A 9559 3397 38053_s_at BRE 9577 3398 39230_at APOBEC3B 9582 3399 39725_at RBM39 9584 3400 39386_at MAD2L1BP 9587 3401 39354_at PRDX6 9588 3402 37680_at AKAP12 9590 3403 36097_at IER2 9592 3404 33343_at RNF14 9604 3405 37890_at CD47 961 3406 39358_at NCOR2 9612 3407 41362_at ABCG1 9619 3408 38651_at FEZ2 9637 3409 34180_at ARHGEF10 9639 3410 40861_at MORF4L2 9643 3411 40844_at CTR9 9646 3412 37384_at PPM1F 9647 3413 37177_at CD58 965 3414 40517_at TTC37 9652 3415 32669_at SOCS5 9655 3416 32662_at MDC1 9656 3417 39422_at PDE4DIP 9659 3418 39351_at CD59 966 3419 38854_at CEP135 9662 3420 40447_at LPIN2 9663 3421 31936_s_at KIAA0430 9665 3422 32099_at SAFB2 9667 3423 40535_i_at EIF5B 9669 3424 32091_at SLC25A44 9673 3425 38204_at KIAA0406 9675 3426 40143_at FAM53B 9679 3427 32069_at N4BP1 9683 3428 40128_at CLINT1 9685 3429 40279_at VGLL4 9686 3430 40108_at NA NA 3431 37645_at CD69 969 3432 34745_at RAPGEF2 9693 3433 40051_at TRAM2 9697 3434 40048_at PUM1 9698 3435 38146_at ST18 9705 3436 39733_at HERPUD1 9709 3437 32208_at KIAA0355 9710 3438 31802_at KIAA0226 9711 3439 34594_at USP6NL 9712 3440 41712_at AQR 9716 3441 39405_at UTP14C 9724 3442 37483_at HDAC9 9734 3443 37438_at CP110 9738 3444 39019_at LAPTM4A 9741 3445 38694_at FAM115A 9747 3446 38669_at SLK 9748 3447 35282_r_at CD81 975 3448 37112_at FAM65B 9750 3449 38271_at HDAC4 9759 3450 41728_at MLEC 9761 3451 38248_at ProSAPiP1 9762 3452 37914_at ZFYVE16 9765 3453 38393_at KIAA0247 9766 3454 37598_at RASSF2 9770 3455 38062_at RAPGEF5 9771 3456 38050_at BCLAF1 9774 3457 37281_at FAM38A 9780 3458 37695_at RNF144A 9781 3459 37265_at RIMS3 9783 3460 37363_at MTSS1 9788 3461 37359_at NA NA 3462 37320_at PTDSS1 9791 3463 37312_at SERTAD2 9792 3464 37293_at CKAP5 9793 3465 37292_at MAML1 9794 3466 37174_at MRPL19 9801 3467 36616_at DAZAP2 9802 3468 36198_at TOMM20 9804 3469 36155_at SPOCK2 9806 3470 41830_at KIAA0494 9813 3471 36741_at GIT2 9815 3472 35322_at KEAP1 9817 3473 40018_at NUPL1 9818 3474 41788_i_at TSC22D2 9819 3475 36057_at ARMCX2 9823 3476 36025_at ARHGEF17 9828 3477 33253_at TRIM14 9830 3478 33528_at KIAA0125 9834 3479 35633_at ELMO1 9844 3480 35252_at KIAA0528 9847 3481 35209_at EPM2AIP1 9852 3482 33893_r_at CEP170 9859 3483 33340_at PJA2 9867 3484 32853_at TOMM70A 9868 3485 35371_at LRBA 987 3486 32224_at FCHSD2 9873 3487 32219_at TLK1 9874 3488 41170_at ZC3H11A 9877 3489 32244_at TOX4 9878 3490 32660_at TRANK1 9881 3491 40160_at POM121 9883 3492 39770_at SMG7 9887 3493 31788_at ZBED4 9889 3494 32175_at SEPT7 989 3495 41101_at FIG4 9896 3496 38032_at SV2A 9900 3497 37408_at MRC2 9902 3498 37230_at KLHL21 9903 3499 40377_at RBM19 9904 3500 35793_at G3BP2 9908 3501 35786_at DENND4B 9909 3502 34445_at RABGAP1L 9910 3503 35314_at NCAPD2 9918 3504 36453_at KBTBD11 9920 3505 34883_at RNF10 9921 3506 34395_at ZBTB5 9925 3507 34387_at LPGAT1 9926 3508 35618_at HELZ 9931 3509 33462_at P2RY14 9934 3510 38149_at ARHGAP25 9938 3511 1347_at CDC25B 994 3512 39136_at OXSR1 9943 3513 38064_at MVP 9961 3514 40998_at MED12 9968 3515 41625_at MED13 9969 3516 35705_at NR1D2 9975 3517 39736_at CDC42 998 3518 37827_r_at DOPEY2 9980 3519 40242_at THOC1 9984 3520 32393_s_at HNRPDL 9987 3521 41808_at DMTF1 9988 3522 34371_at PPP4R1 9989 # Name Date of diagnosis Gender of the patient Age of the patient at entry does the patient have B-cell or T-cell ALL Complete remission(CR), refractory(REF) or NA. Derived from CR Original remisson data Date complete remission if achieved did the patient have t(4;11) translocation. Derived from citog did the patient have t(9;22) translocation. Derived from citog Was cytogenetic test normal? Derived from citog original citogenetics data, deletions or t(4;11), t(9;22) status molecular biology which of p190, p210 or p190/210 for bcr/able multi-drug resistant ploidy: either diploid or hyperd. Continuous complete remission? Derived from f.u Relapse? Derived from f.u did the patient receive a bone marrow transplant? Derived from f.u follow up data available date patient was last seen 1 57001 1/29/1997 1 53 4 NA DEATH IN INDUCTION NA FALSE FALSE TRUE normal 4 NA 1 2 NA NA NA NA NA 2 LAL4 NA NA NA 6 NA NA NA NA NA NA NA 4 NA NA NA NA NA NA NA NA 3 43012 1/15/1999 2 18 5 1 CR 3/22/1999 NA NA NA NA 4 NA 1 1 FALSE TRUE FALSE REL 4/20/2000 4 28023 2/26/1998 2 26 4 1 CR 4/20/1998 FALSE FALSE TRUE normal 4 NA 1 1 FALSE TRUE FALSE REL / SNC 2/5/1999 5 28024 4/19/1998 1 19 2 1 CR 6/17/1998 FALSE FALSE FALSE complex alt. 4 NA 1 2 TRUE FALSE FALSE CCR 12/31/2002 6 15005 5/4/2000 2 28 3 1 CR 6/26/2000 FALSE TRUE FALSE t(9;22)+other 2 1 2 2 FALSE TRUE FALSE REL 11/15/2000 7 16004 4/19/1997 1 58 2 1 CR 7/15/1997 TRUE FALSE FALSE t(4;11) 1 NA 1 1 FALSE TRUE FALSE REL 12/9/1997 8 28003 11/28/1996 2 18 5 1 CR 1/17/1997 NA NA NA NA 3 NA 1 2 TRUE FALSE FALSE CCR 12/31/2002 9 31007 2/20/1997 2 25 2 1 CR 5/15/1997 TRUE FALSE FALSE t(4;11) 1 NA 1 1 FALSE TRUE FALSE REL 12/3/1998 10 28036 12/23/1998 2 52 4 1 CR 3/8/1999 FALSE TRUE FALSE t(9;22) 2 1 1 1 FALSE TRUE FALSE REL 3/15/1999 11 08001 1/15/1997 2 40 3 1 CR 3/26/1997 FALSE FALSE FALSE del(p15) 2 1 1 NA FALSE TRUE FALSE REL 7/11/1997 12 48001 3/22/1997 2 19 3 1 CR 5/20/1997 FALSE FALSE FALSE complex alt. 4 NA 1 2 FALSE FALSE FALSE MUD / DEATH IN CR 12/18/1998 13 17003 4/8/1997 1 40 6 2 REF NA NA NA NA NA 4 NA 2 1 NA NA NA NA NA 14 37013 5/28/1998 2 NA 3 NA NA NA FALSE FALSE FALSE del(p15/p16) 2 NA 1 1 NA NA NA NA NA 15 08012 10/22/1998 2 55 4 1 CR 1/9/1999 FALSE FALSE FALSE simple alt. 4 NA 1 1 FALSE TRUE FALSE REL 4/9/1999 16 22010 12/31/1999 1 26 1 NA NA NA FALSE TRUE FALSE t(9;22) 2 2 1 1 NA NA NA NA NA 17 24008 5/14/1997 1 20 3 1 CR 7/31/1997 NA NA NA NA 4 NA 1 1 FALSE FALSE TRUE BMT / CCR 00/09/20+T12501 18 28031 9/23/1998 2 18 2 1 CR 12/7/1998 FALSE FALSE TRUE normal 4 NA 1 1 FALSE TRUE FALSE REL 1/17/1999 19 62001 11/11/1997 1 50 5 2 REF NA FALSE TRUE FALSE t(9;22)+other 2 NA 1 2 NA NA NA NA NA 20 15004 2/10/2000 2 44 2 1 CR 4/3/2000 TRUE FALSE FALSE t(4;11) 1 NA 1 1 FALSE TRUE FALSE REL 12/19/2000 21 28043 6/28/1999 2 23 4 1 CR 8/23/1999 NA NA NA NA 4 NA 1 1 FALSE TRUE FALSE REL 3/29/2001 22 28044 7/20/1999 2 16 4 1 CR 9/20/1999 FALSE FALSE FALSE complex alt. 4 NA 1 1 FALSE TRUE FALSE REL 12/23/1999 23 06002 3/19/1997 2 15 3 1 CR 6/9/1997 FALSE FALSE TRUE normal 4 NA 1 1 FALSE TRUE FALSE REL 3/18/1998 24 28042 6/18/1999 2 18 4 1 CR 8/9/1999 NA NA NA NA 4 NA 1 1 FALSE TRUE FALSE REL 11/30/2002 25 11002 12/23/1996 2 30 6 1 CR 3/18/1997 FALSE FALSE TRUE normal 4 NA 1 1 FALSE TRUE FALSE REL 4/14/1998 26 28032 9/26/1998 1 52 2 1 CR 10/30/1998 TRUE FALSE FALSE t(4;11) 1 NA 1 1 TRUE FALSE FALSE CCR 5/16/2002 27 28021 3/18/1998 1 54 4 1 DEATH IN CR 5/22/1998 FALSE TRUE FALSE t(9;22)+other 2 2 1 2 FALSE FALSE FALSE DEATH IN CR (ICR) NA 28 28028 7/8/1998 2 47 2 1 CR 9/3/1998 TRUE FALSE FALSE t(4;11) 1 NA 1 1 FALSE TRUE FALSE REL 10/20/1999 29 28035 12/21/1998 2 27 4 1 CR 2/12/1999 NA NA NA NA 4 NA 2 2 TRUE FALSE FALSE CCR 5/20/2002 30 09008 12/17/1999 2 41 4 1 CR 2/15/2000 FALSE TRUE FALSE t(9;22)+other 2 1 1 2 TRUE FALSE TRUE BMT / CCR 00/09/01 31 11005 6/1/1998 2 27 3 1 DEATH IN CR 8/3/1998 FALSE FALSE FALSE del(7q) + altro 2 1 1 1 FALSE FALSE FALSE DEATH IN CR NA 32 26003 2/18/1998 1 49 5 1 CR 4/21/1998 FALSE FALSE FALSE del(p15/p16) 2 3 1 1 FALSE TRUE FALSE REL 7/1/1998 33 20002 5/9/1997 1 58 3 1 CR 8/19/1997 FALSE TRUE FALSE t(9;22)+other 2 1 1 1 FALSE TRUE FALSE REL 12/15/1997 34 28019 2/10/1998 2 21 5 1 CR 4/2/1998 NA NA NA NA 2 1 1 2 TRUE FALSE TRUE BMT / CCR 3/21/2001 35 04010 10/30/1997 1 18 2 1 CR 1/7/1998 FALSE FALSE FALSE complex alt. 4 NA 2 2 FALSE TRUE FALSE REL 3/5/1998 36 01010 3/29/2000 2 19 3 1 CR 6/27/2000 FALSE FALSE FALSE simple alt. 4 NA 2 1 FALSE TRUE FALSE REL 8/28/2000 37 25006 3/18/2000 NA NA 3 1 CR 5/8/2000 NA NA NA NA 4 NA 1 NA TRUE FALSE FALSE CCR 3/3/2002 38 30001 1/16/1997 1 54 4 NA DEATH IN INDUCTION NA FALSE TRUE FALSE t(9;22)+other 2 1 1 2 NA NA NA NA NA 39 33005 2/10/1998 1 19 2 1 CR 4/29/1998 FALSE FALSE FALSE complex alt. 4 NA 1 1 TRUE FALSE FALSE CCR 6/28/2002 40 64002 10/21/1997 1 26 3 1 CR 1/21/1998 NA NA NA NA 4 NA 1 2 FALSE FALSE TRUE BMT / DEATH IN CR NA 41 68001 5/15/1997 2 36 2 1 CR 7/22/1997 FALSE FALSE TRUE normal 4 NA 1 1 TRUE FALSE FALSE CCR 5/10/2002 42 24019 5/4/1999 2 16 5 1 CR 7/28/1999 FALSE FALSE FALSE t(1;19) + del(6q) 3 NA 1 1 FALSE TRUE FALSE REL 5/25/2000 43 16009 7/11/2000 1 43 3 NA NA NA NA NA NA NA 4 NA 2 1 TRUE FALSE FALSE CCR / OFF 5/23/2002 44 26008 8/25/1999 1 17 2 1 CR 10/14/1999 FALSE FALSE TRUE normal 1 NA 1 1 FALSE TRUE FALSE REL 6/26/2000 45 04006 7/17/1997 2 38 2 1 CR 9/8/1997 TRUE FALSE FALSE t(4;11) 1 NA 1 1 FALSE TRUE FALSE REL 1/23/1998 46 12007 3/11/1997 2 37 3 1 CR 5/7/1997 FALSE TRUE FALSE t(9;22)+ del(9) 2 NA 1 1 FALSE TRUE FALSE REL 9/26/1997 47 19014 3/24/1999 2 31 8 1 CR 5/13/1999 FALSE FALSE FALSE simple alt. 4 NA 1 1 FALSE TRUE FALSE REL 4/1/2000 48 08018 8/27/1999 2 5 4 1 CR 10/18/1999 NA NA NA NA 3 NA 1 1 FALSE TRUE FALSE REL 5/23/2000 49 08024 7/20/2000 2 18 3 1 DEATH IN CR NA FALSE FALSE FALSE simple alt. 4 NA 2 1 NA NA NA NA NA 50 04008 7/30/1997 2 17 2 1 CR 9/27/1997 FALSE FALSE FALSE complex alt. 4 NA 1 2 FALSE TRUE FALSE REL 12/15/1997 51 01005 5/21/1997 2 53 3 1 CR 8/6/1997 FALSE TRUE FALSE t(9;22) 2 3 1 1 FALSE FALSE TRUE BMT / DEATH IN CR NA 52 65003 3/27/1998 2 30 9 1 CR 5/27/1998 FALSE FALSE FALSE simple alt. 4 NA 1 1 FALSE TRUE FALSE REL 2/11/1999 53 64001 8/28/1997 2 20 3 1 CR 10/27/1997 FALSE FALSE FALSE simple alt. 4 NA 1 1 FALSE TRUE FALSE REL 1/21/1998 54 65005 7/20/1999 2 22 3 2 REF NA FALSE TRUE FALSE t(9;22)+del(p15/p16) 2 1 1 1 NA NA NA NA NA 55 26005 8/21/1998 2 38 3 1 CR 11/15/1998 NA NA NA NA 6 NA 1 1 FALSE TRUE FALSE REL 3/4/2002 56 26001 9/27/1997 2 21 3 1 CR 12/11/1997 NA NA NA NA 4 NA 2 1 TRUE FALSE FALSE CCR 7/31/2002 57 63001 7/8/1997 2 49 2 1 CR 9/2/1997 NA NA NA NA 1 NA 1 1 FALSE TRUE FALSE REL 6/10/1998 58 28047 4/17/2000 2 NA 4 1 CR NA FALSE FALSE FALSE simple alt. 4 NA 1 1 FALSE TRUE FALSE REL 9/4/2000 59 28007 2/21/1997 1 47 4 1 CR 4/7/1997 FALSE FALSE TRUE normal 4 NA 1 1 TRUE FALSE FALSE CCR 3/22/2002 60 24011 8/5/1997 1 51 3 NA DEATH IN INDUCTION NA FALSE TRUE FALSE t(9;22) 2 3 2 1 NA NA NA NA NA 61 24022 12/21/1999 1 32 5 2 REF NA FALSE TRUE FALSE t(9;22) 2 1 2 1 NA NA NA NA NA 62 12026 5/29/1998 2 39 3 2 REF NA FALSE TRUE FALSE t(9;22) 2 2 NA 1 FALSE FALSE FALSE DEATH IN CR NA 63 62003 12/4/1998 2 53 5 1 CR 1/28/1999 FALSE TRUE FALSE t(9;22)+other 2 3 1 2 FALSE TRUE FALSE REL 8/8/2000 64 24005 1/3/1997 1 45 2 1 CR 4/8/1997 TRUE FALSE FALSE t(4;11) 1 NA 1 1 FALSE TRUE FALSE REL 8/28/1997 65 24018 2/18/1999 1 29 3 1 CR 5/4/1999 NA NA NA NA 4 NA 2 1 FALSE TRUE FALSE REL 7/22/2000 66 04007 7/22/1997 2 57 3 1 CR 9/17/1997 FALSE FALSE FALSE del(6q) 4 NA 1 1 FALSE TRUE FALSE REL 11/4/1997 67 28001 10/19/1996 2 16 4 2 REF NA FALSE FALSE TRUE normal 4 NA 2 1 NA NA NA NA NA 68 22009 8/10/1999 1 19 1 NA NA NA FALSE FALSE FALSE simple alt. 4 NA 1 1 NA NA NA NA NA 69 28006 1/13/1997 2 22 4 1 CR 3/14/1997 FALSE FALSE FALSE del(6q) 4 NA 1 1 FALSE TRUE FALSE REL 1/16/1998 70 28005 12/27/1996 2 17 4 1 CR 2/26/1997 FALSE FALSE FALSE complex alt. 4 NA 2 2 FALSE TRUE FALSE REL 3/6/1998 71 04016 2/10/2000 2 16 2 1 CR 4/17/2000 FALSE FALSE FALSE simple alt. 4 NA 1 1 FALSE TRUE FALSE REL 9/26/2000 72 36002 4/1/1998 2 23 3 1 CR 6/9/1998 FALSE FALSE TRUE normal 4 NA 1 2 FALSE TRUE FALSE REL 3/29/2001 73 09017 2/3/2000 1 27 1 1 CR 3/23/2000 FALSE FALSE TRUE normal 4 NA 1 1 FALSE TRUE FALSE REL 9/11/2001 74 43004 2/4/1997 1 37 4 1 CR 4/1/1997 NA NA NA NA 4 NA 1 1 TRUE FALSE FALSE CCR 3/20/2001 75 43007 10/14/1997 2 54 5 1 CR 12/30/1997 FALSE FALSE TRUE normal 4 NA 1 2 TRUE FALSE FALSE CCR 5/29/2002 76 14016 5/27/1999 2 53 3 NA NA NA FALSE TRUE FALSE t(9;22) 2 3 1 NA NA NA NA NA NA 77 25003 5/22/1998 2 15 3 1 CR 8/4/1998 FALSE FALSE FALSE simple alt. 4 NA 2 1 TRUE FALSE FALSE CCR 6/10/2002 78 19005 11/15/1997 1 48 2 1 CR 2/3/1998 FALSE FALSE TRUE normal 1 NA 1 1 FALSE TRUE FALSE REL 2/4/1998 79 15001 9/3/1997 2 20 2 1 CR 11/11/1997 FALSE FALSE TRUE normal 4 NA 1 1 TRUE FALSE FALSE CCR 6/21/2002 80 27004 10/20/1998 1 48 3 2 REF NA FALSE TRUE FALSE t(9;22)+del(p15) 2 1 1 1 NA NA NA NA NA 81 12019 9/4/1997 2 53 3 1 CR 11/11/1997 FALSE FALSE TRUE normal 4 NA 2 1 TRUE FALSE FALSE CCR 6/6/2002 82 12012 5/21/1997 1 36 4 2 REF NA FALSE TRUE FALSE t(9;22) 2 1 1 1 NA NA NA NA NA 83 27003 1/17/1998 1 26 3 1 CR 3/16/1998 NA NA NA NA 2 2 2 1 FALSE TRUE FALSE REL 5/6/1998 84 62002 1/15/1998 2 54 5 NA DEATH IN INDUCTION NA FALSE TRUE FALSE t(9;22)+other 2 NA 1 2 NA NA NA NA NA 85 08011 8/21/1998 2 33 4 1 CR 10/8/1998 FALSE FALSE FALSE del(p15/p16) 2 2 1 1 FALSE FALSE TRUE BMT / DEATH IN CR NA 86 22011 4/7/2000 2 19 3 1 CR 5/19/2000 FALSE FALSE TRUE normal 4 NA 1 1 TRUE FALSE FALSE CCR 7/31/2002 87 24001 10/4/1996 1 17 3 1 CR 12/20/1996 NA NA NA NA 2 1 1 1 FALSE TRUE FALSE REL 2/10/1997 88 22013 8/17/2000 2 32 3 2 REF NA FALSE TRUE FALSE t(9;22)+other 2 2 1 1 NA NA NA NA NA 89 03002 6/24/1998 1 52 5 1 CR 8/17/1998 NA NA NA NA 2 1 1 1 FALSE TRUE FALSE REL 10/15/1999 90 31011 11/15/1997 2 31 4 1 CR 1/21/1998 FALSE TRUE FALSE t(9;22) 2 3 2 1 FALSE TRUE TRUE AUBMT / REL 6/1/1998 91 28037 12/30/1998 2 18 4 1 CR 3/4/1999 FALSE FALSE TRUE normal 4 NA 2 1 FALSE TRUE FALSE REL 4/23/2001 92 64005 10/1/1998 2 19 8 2 REF NA NA NA NA NA 4 NA 1 1 NA NA NA NA NA 93 36001 9/29/1997 1 24 5 1 CR 12/5/1997 FALSE FALSE TRUE normal 3 NA 1 1 FALSE TRUE FALSE REL 1/7/1998 94 68003 4/11/2000 1 27 3 NA DEATH IN INDUCTION NA FALSE TRUE FALSE t(9;22)+other 2 1 1 NA NA NA NA NA NA 95 84004 9/25/1998 2 50 1 1 CR 12/1/1998 NA NA NA NA 2 1 1 1 FALSE TRUE FALSE REL 1/25/1999 96 56007 8/6/1999 2 37 9 1 CR 9/24/1999 NA NA NA NA 4 NA 1 1 TRUE FALSE FALSE CCR 1/26/2001 97 24010 6/3/1997 1 16 3 1 CR 8/11/1997 FALSE TRUE FALSE t(9;22) 2 2 1 1 FALSE TRUE TRUE BMT / REL 8/24/1998 98 49004 9/18/1997 2 24 9 1 CR 11/11/1997 FALSE FALSE FALSE del(7q) 4 NA 2 1 TRUE FALSE FALSE CCR 6/14/2001 99 20005 3/15/2000 2 24 7 1 CR 5/5/2000 NA NA NA NA 4 NA 1 1 TRUE FALSE FALSE CCR 3/20/2002 100 02020 3/23/2000 1 48 8 NA DEATH IN INDUCTION NA FALSE FALSE FALSE complex alt. 4 NA 1 1 NA NA NA NA NA 101 09002 5/14/1998 1 40 9 1 CR 7/21/1998 NA NA NA NA 4 NA 1 1 FALSE TRUE FALSE REL / SNC 9/14/1999 102 10005 9/30/1997 2 22 8 1 CR 1/26/1998 NA NA NA NA 4 NA 1 1 FALSE TRUE FALSE REL 10/10/1999 103 28008 3/27/1997 2 23 8 1 CR 5/27/1997 FALSE FALSE TRUE normal 4 NA 1 2 TRUE FALSE FALSE CCR 4/9/2002 104 01003 2/18/1997 2 31 6 1 CR 4/29/1997 FALSE FALSE TRUE normal 4 NA 1 1 FALSE TRUE FALSE REL 7/11/1997 105 16002 4/10/1997 2 50 9 1 CR 6/10/1997 NA NA NA NA 4 NA 1 2 FALSE TRUE FALSE REL 12/7/1999 106 19017 3/17/2000 2 14 8 1 CR 6/15/2000 FALSE FALSE TRUE normal 4 NA 2 1 FALSE TRUE FALSE REL 7/5/2001 107 49006 8/12/1998 1 43 3 1 CR 11/19/1998 NA NA NA NA 2 3 1 1 FALSE TRUE FALSE REL 4/26/1999 108 15006 6/10/1998 2 22 8 1 CR 8/11/1998 FALSE FALSE FALSE complex alt. 4 NA 1 2 FALSE TRUE FALSE REL 9/15/2000 109 12006 2/20/1997 2 46 4 2 REF NA FALSE TRUE FALSE t(9;22) 2 3 1 1 NA NA NA NA NA 110 16007 11/1/1998 2 41 9 1 CR 11/5/1998 NA NA NA NA 4 NA 1 1 TRUE FALSE FALSE CCR 1/8/2002 111 19008 4/29/1998 1 16 8 2 REF NA FALSE FALSE TRUE normal 4 NA 2 1 NA NA NA NA NA 112 01007 9/30/1998 1 16 9 1 CR 11/30/1998 FALSE FALSE FALSE simple alt. 5 NA 1 2 FALSE FALSE TRUE BMT / DEATH IN CR NA 113 04018 3/24/2000 2 17 8 1 CR 5/23/2000 FALSE FALSE FALSE simple alt. 4 NA 1 1 TRUE FALSE FALSE CCR 5/14/2001 114 19002 1/29/1997 2 25 9 1 CR 4/10/1997 FALSE FALSE FALSE simple alt. 4 NA 1 2 FALSE TRUE FALSE REL 11/10/1997 115 24006 1/14/1997 1 19 10 1 CR not known FALSE FALSE FALSE simple alt. 4 NA 1 1 TRUE FALSE FALSE CCR 6/5/2002 116 26009 8/26/1999 2 37 6 1 CR 10/18/1999 FALSE FALSE TRUE normal 4 NA 1 1 FALSE TRUE FALSE REL 6/12/2000 117 28009 4/19/1997 1 30 9 1 CR 6/13/1997 NA NA NA NA 4 NA 1 1 FALSE TRUE FALSE REL 6/30/1998 118 31015 12/3/1998 2 48 8 NA DEATH IN INDUCTION NA NA NA NA NA 4 NA 2 1 NA NA NA NA NA 119 37001 1/30/1997 2 22 8 1 CR 4/3/1997 NA NA NA NA 4 NA 1 1 FALSE TRUE FALSE REL 1/7/1998 120 12008 3/22/1997 2 18 10 2 REF NA FALSE FALSE FALSE del(6q) 4 NA 1 1 NA NA NA NA NA 121 43006 6/17/1997 2 41 8 2 REF NA FALSE FALSE FALSE simple alt. 4 NA 2 1 NA NA NA NA NA 122 43015 2/29/2000 2 52 8 1 CR 6/8/2000 FALSE FALSE TRUE normal 4 NA 1 1 FALSE TRUE FALSE REL 3/15/2002 123 44001 1/15/1997 2 32 9 1 CR 3/7/1997 FALSE FALSE FALSE del(6q) 4 NA 1 NA FALSE TRUE FALSE REL 11/25/1997 124 18001 4/23/1997 1 28 8 2 REF NA NA NA NA NA 4 NA 1 2 NA NA NA NA NA 125 43001 11/14/1996 2 41 2 1 CR 1/30/1997 FALSE TRUE FALSE t(9;22) 2 2 2 1 FALSE TRUE FALSE REL 6/28/1998 126 24017 9/15/1998 2 57 3 1 CR 12/7/1998 FALSE TRUE FALSE t(9;22)+other 2 1 1 2 FALSE TRUE FALSE REL 2/22/2000 127 LAL5 NA NA NA 1 NA NA NA NA NA NA NA 3 NA NA NA NA NA NA NA NA 128 83001 10/23/1998 2 29 8 1 CR 12/21/1998 FALSE FALSE FALSE complex alt. 4 NA 1 2 TRUE FALSE FALSE CCR 5/24/2002 # Name iterations oscillation thr.row thr.col freq rob rob.limit # GO Term Ontology PValue OddsRatio ExpCount Count Size # KEGG Path Name PValue OddsRatio ExpCount Count Size 1 module 1 7 0 4 3 2 12.34 5.90 947 948 949 950 951 945 946 1.00 0.64 0.65 0.73 0.90 0.66 0.67 89 93 107 0.75 1.00 0.91 9 18 1 GO:0006986 response to unfolded protein BP 1.46e-08 942.19 0.04 5 21 2 GO:0051789 response to protein stimulus BP 3.56e-07 454.24 0.08 5 38 3 GO:0009607 response to biotic stimulus BP 2.21e-04 113.40 0.26 5 133 4 GO:0006457 protein folding BP 6.22e-04 100.75 0.12 4 63 5 GO:0042026 protein refolding BP 2.47e-03 1515.00 5.93e-03 2 3 6 GO:0051131 chaperone-mediated protein complex assembly BP 2.47e-03 1515.00 5.93e-03 2 3 7 GO:0010033 response to organic substance BP 3.31e-03 62.66 0.45 5 229 8 GO:0006458 'de novo' protein folding BP 0.02 252.08 0.02 2 8 9 GO:0042221 response to chemical stimulus BP 0.04 35.74 0.74 5 377 10 GO:0051082 unfolded protein binding MF 4.94e-05 129.74 0.10 4 51 11 GO:0051087 chaperone binding MF 0.01 128.50 0.03 2 14 2 module 2 10 0 4 3 2 7.02 5.90 1060 1055 1056 1057 1058 1059 0.88 0.82 1.00 0.93 0.87 0.79 35 39 4 24 3 0.39 0.33 0.68 0.16 1.00 57 3 module 3 8 0 4 2.5 1 6.33 5.86 665 666 -0.80 -1.00 104 105 110 103 52 -0.95 -0.82 -0.58 -1.00 -0.60 72 77 1 GO:0004875 complement receptor activity MF 0.01 Inf 6.45e-04 1 1 2 GO:0001848 complement binding MF 0.03 1549.00 1.93e-03 1 3 4 module 4 8 0 4 2.5 1 8.90 5.86 1099 1093 1094 1095 1096 1097 1098 0.66 0.72 0.72 0.78 0.77 1.00 0.65 48 42 40 8 93 127 1.00 0.91 0.25 0.60 0.14 0.72 58 61 62 81 82 1 GO:0004914 interleukin-5 receptor activity MF 0.03 Inf 9.67e-04 1 1 2 GO:0019980 interleukin-5 binding MF 0.03 Inf 9.67e-04 1 1 3 GO:0004912 interleukin-3 receptor activity MF 0.05 1549.00 1.93e-03 1 2 4 GO:0019978 interleukin-3 binding MF 0.05 1549.00 1.93e-03 1 2 5 module 5 7 0 4 2.5 1 10.49 5.86 345 383 384 385 386 387 388 389 390 391 340 299 300 338 -0.72 -0.78 -0.79 -0.92 -0.66 -0.65 -0.66 -0.83 -0.68 -0.73 -0.96 -1.00 -0.83 -0.85 62 78 -1.00 -0.37 10 17 23 26 31 33 44 54 1 04060 Cytokine-cytokine receptor interaction 0.04 26.96 0.15 2 53 6 module 6 7 0 4 2.5 1 6.06 5.86 1028 255 256 257 -0.91 -0.89 -1.00 -0.92 110 98 -1.00 -0.74 35 50 64 1 04640 Hematopoietic cell lineage 0.03 37.54 0.11 2 39 7 module 7 7 0 4 2.5 3 13.22 5.86 4 5 6 7 8 9 21 22 -0.84 -0.88 -1.00 -0.99 -0.97 -0.82 -0.75 -0.71 33 41 1 -1.00 -0.79 -0.86 8 12 30 1 GO:0006882 cellular zinc ion homeostasis BP 1.34e-03 1211.60 6.91e-03 2 3 2 GO:0055069 zinc ion homeostasis BP 1.34e-03 1211.60 6.91e-03 2 3 3 GO:0046870 cadmium ion binding MF 3.34e-15 9279.00 0.02 6 7 4 GO:0005507 copper ion binding MF 1.75e-11 660.00 0.05 6 20 5 GO:0008270 zinc ion binding MF 1.24e-04 44.32 1.11 7 429 6 GO:0046914 transition metal ion binding MF 5.11e-04 34.33 1.37 7 531 7 GO:0046872 metal ion binding MF 6.62e-03 21.02 2.01 7 780 8 GO:0043169 cation binding MF 6.79e-03 20.66 2.04 7 790 9 GO:0043167 ion binding MF 6.81e-03 20.38 2.06 7 798 8 module 8 9 0 4 2 2 15.42 9.93 4 5 6 7 8 10 0.96 0.93 0.97 0.99 1.00 0.82 1 33 41 40 62 55 0.86 1.00 0.92 0.81 0.74 0.78 7 12 30 1 GO:0046870 cadmium ion binding MF 5.68e-17 Inf 0.01 6 7 2 GO:0005507 copper ion binding MF 2.83e-13 Inf 0.04 6 20 3 GO:0008270 zinc ion binding MF 5.43e-05 Inf 0.83 6 429 4 GO:0046914 transition metal ion binding MF 1.72e-04 Inf 1.03 6 531 5 GO:0046872 metal ion binding MF 1.49e-03 Inf 1.51 6 780 6 GO:0043169 cation binding MF 1.49e-03 Inf 1.53 6 790 7 GO:0043167 ion binding MF 1.49e-03 Inf 1.54 6 798 9 module 9 7 0 4 2 4 12.19 9.93 947 948 949 950 951 952 953 1.00 0.59 0.53 0.60 0.87 0.68 0.57 89 93 107 88 92 0.62 1.00 0.84 0.63 0.49 1 18 1 GO:0006986 response to unfolded protein BP 6.49e-06 354.59 0.04 4 21 2 GO:0051789 response to protein stimulus BP 7.90e-05 176.29 0.08 4 38 3 GO:0009607 response to biotic stimulus BP 0.01 44.99 0.26 4 133 4 GO:0042221 response to chemical stimulus BP 0.04 35.74 0.74 5 377 5 GO:0006457 protein folding BP 0.04 49.52 0.12 3 63 6 GO:0051082 unfolded protein binding MF 3.64e-03 63.50 0.10 3 51 10 module 10 8 0 4 2 2 18.74 9.93 394 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 340 345 350 395 0.61 0.57 0.57 0.86 0.92 0.75 0.61 0.76 0.60 0.76 0.88 0.90 0.58 0.56 0.90 0.77 0.94 0.91 0.63 1.00 0.88 0.83 0.79 0.80 0.66 0.90 0.57 0.85 0.72 0.61 0.57 0.71 72 66 62 61 105 60 59 0.43 0.49 0.90 0.55 0.70 0.52 1.00 5 17 23 26 31 33 44 54 1 GO:0032781 positive regulation of ATPase activity BP 2.75e-04 Inf 0.03 3 3 2 GO:0043462 regulation of ATPase activity BP 1.09e-03 392.61 0.03 3 4 3 GO:0015669 gas transport BP 2.71e-03 196.24 0.04 3 5 4 GO:0006783 heme biosynthetic process BP 5.38e-03 130.78 0.05 3 6 5 GO:0006779 porphyrin biosynthetic process BP 9.35e-03 98.05 0.06 3 7 6 GO:0033014 tetrapyrrole biosynthetic process BP 9.35e-03 98.05 0.06 3 7 7 GO:0042168 heme metabolic process BP 9.35e-03 98.05 0.06 3 7 8 GO:0006778 porphyrin metabolic process BP 0.01 78.42 0.07 3 8 9 GO:0033013 tetrapyrrole metabolic process BP 0.01 78.42 0.07 3 8 10 GO:0015670 carbon dioxide transport BP 0.03 Inf 0.02 2 2 11 GO:0046689 response to mercury ion BP 0.03 Inf 0.02 2 2 12 GO:0008519 ammonium transmembrane transporter activity MF 0.01 Inf 0.02 2 2 13 GO:0015101 organic cation transmembrane transporter activity MF 0.01 Inf 0.02 2 2 14 GO:0030506 ankyrin binding MF 0.01 Inf 0.02 2 2 15 GO:0008092 cytoskeletal protein binding MF 0.03 7.28 1.29 7 148 16 GO:0034416 bisphosphoglycerate phosphatase activity MF 0.03 245.92 0.03 2 3 1 00860 Porphyrin and chlorophyll metabolism 4.68e-06 134.57 0.08 4 11 11 module 11 8 0 4 2 1 10.63 9.93 41 40 -0.94 -1.00 113 114 115 117 119 116 123 92 -0.96 -0.87 -1.00 -0.86 -0.79 -0.86 -0.79 -0.91 27 46 51 53 64 72 77 80 12 module 12 8 0 4 2 1 14.12 9.93 4 5 6 7 8 9 0.85 0.86 0.96 0.98 1.00 0.81 1 33 41 40 52 0.84 1.00 0.82 0.70 0.72 7 8 30 1 GO:0046870 cadmium ion binding MF 5.68e-17 Inf 0.01 6 7 2 GO:0005507 copper ion binding MF 2.83e-13 Inf 0.04 6 20 3 GO:0008270 zinc ion binding MF 5.43e-05 Inf 0.83 6 429 4 GO:0046914 transition metal ion binding MF 1.72e-04 Inf 1.03 6 531 5 GO:0046872 metal ion binding MF 1.49e-03 Inf 1.51 6 780 6 GO:0043169 cation binding MF 1.49e-03 Inf 1.53 6 790 7 GO:0043167 ion binding MF 1.49e-03 Inf 1.54 6 798 13 module 13 9 0 4 1.5 1 12.30 11.18 205 204 203 416 1033 202 -0.93 -0.97 -0.97 -0.99 -0.93 -1.00 69 57 97 103 102 25 41 43 45 108 66 7 59 95 54 0.86 0.88 0.89 0.89 1.00 0.88 0.04 0.12 0.17 0.16 0.69 0.14 0.68 0.72 0.71 16 19 21 29 34 37 38 42 47 48 49 55 56 57 58 59 61 62 63 70 14 module 14 8 0 4 1.5 2 16.31 11.18 47 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 0.65 0.68 0.85 0.98 0.77 0.80 0.86 0.94 0.66 1.00 0.86 0.85 0.79 0.80 0.89 0.88 0.68 50 16 17 69 12 79 68 67 70 25 36 37 0.41 0.35 0.39 0.45 0.45 0.96 0.69 0.87 1.00 0.80 0.68 0.53 15 20 56 1 GO:0009615 response to virus BP 5.51e-08 54.94 0.33 8 62 2 GO:0051707 response to other organism BP 4.08e-06 30.14 0.55 8 105 3 GO:0051704 multi-organism process BP 1.63e-05 19.23 1.32 10 251 4 GO:0009607 response to biotic stimulus BP 2.66e-05 23.17 0.70 8 133 5 GO:0050896 response to stimulus BP 0.03 7.93 4.43 12 841 6 GO:0005062 hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity MF 6.59e-03 280.64 0.02 2 4 1 04622 RIG-I-like receptor signaling pathway 0.02 52.11 0.07 2 20 15 module 15 8 0 4 1 2 19.16 13.01 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 47 30 31 0.66 0.88 1.00 0.72 0.81 0.80 0.93 0.72 0.93 0.85 0.81 0.71 0.74 0.87 0.96 0.63 0.57 0.59 50 16 17 69 12 79 68 67 70 25 36 37 43 41 66 71 11 15 80 29 10 107 53 54 104 100 106 103 118 0.42 0.37 0.42 0.44 0.49 0.95 0.72 0.90 1.00 0.76 0.69 0.59 0.30 0.19 0.38 0.26 -0.55 -0.55 -0.65 0.29 -0.55 -0.57 0.21 -0.70 0.33 0.24 0.23 0.23 0.30 14 20 56 1 GO:0009615 response to virus BP 1.00e-07 48.82 0.35 8 62 2 GO:0051707 response to other organism BP 7.35e-06 26.79 0.59 8 105 3 GO:0009607 response to biotic stimulus BP 4.77e-05 20.59 0.74 8 133 4 GO:0051704 multi-organism process BP 5.23e-04 12.91 1.41 9 251 5 GO:0032020 ISG15-protein conjugation BP 0.04 201.20 0.02 2 4 6 GO:0005062 hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity MF 6.32e-03 257.17 0.02 2 4 1 04622 RIG-I-like receptor signaling pathway 0.02 52.11 0.07 2 20 2 04620 Toll-like receptor signaling pathway 0.05 27.27 0.13 2 36 16 module 16 8 0 4 1 1 16.55 13.01 234 235 236 237 225 226 227 228 229 230 231 232 233 205 204 0.73 0.73 0.73 0.74 0.75 0.89 0.79 0.76 0.75 0.76 0.85 0.75 1.00 0.75 0.87 115 16 74 110 54 66 7 59 95 71 64 65 61 56 67 27 5 24 120 47 2 62 76 68 88 8 28 9 12 1 84 63 94 13 117 119 91 39 31 41 102 15 87 90 100 105 124 -0.17 -0.14 -0.09 -0.77 -0.82 -1.00 0.07 -0.85 -0.91 -0.73 -0.91 0.06 -0.87 -0.05 0.42 -0.82 -0.89 -0.07 2.17e-03 -0.03 0.06 -0.16 -0.16 -0.16 -0.12 -0.11 -0.76 -0.13 -0.17 -0.72 -0.75 -0.13 -0.73 -0.17 -0.20 -0.17 -0.71 -0.77 -0.14 -0.18 -0.84 -0.72 -0.73 -0.71 -0.19 -0.74 -0.74 13 19 21 29 34 37 38 42 49 55 1 GO:0005576 extracellular region CC 3.11e-05 21.64 0.92 8 222 17 module 17 7 0 4 1 2 19.83 13.01 305 306 307 308 309 310 311 312 313 314 340 336 337 0.80 0.89 0.87 0.83 0.85 0.88 1.00 0.77 0.94 0.95 0.76 0.94 0.86 51 124 58 66 61 62 78 76 122 16 43 82 79 83 80 22 90 74 75 3 107 84 25 99 115 103 117 92 52 106 77 1 87 55 104 -8.37e-03 -0.61 -0.64 -0.62 0.38 0.62 -0.01 0.41 0.40 1.00 5.54e-03 0.15 -0.68 0.21 -0.75 -0.62 0.10 -0.62 -0.63 -0.65 -0.69 0.25 -0.66 -0.63 -0.02 -0.74 -0.65 0.15 0.34 -0.68 -0.67 0.05 -0.61 -0.63 1.17e-04 5 10 23 26 31 33 44 54 1 GO:0005576 extracellular region CC 1.41e-04 23.57 0.78 7 222 2 GO:0005578 proteinaceous extracellular matrix CC 4.59e-03 52.65 0.09 3 25 3 GO:0031012 extracellular matrix CC 8.74e-03 41.29 0.11 3 31 4 GO:0044421 extracellular region part CC 0.03 14.75 0.42 4 120 5 GO:0019863 IgE binding MF 4.12e-04 Inf 7.09e-03 2 2 6 GO:0005509 calcium ion binding MF 2.11e-03 18.53 0.49 5 138 7 GO:0019865 immunoglobulin binding MF 2.32e-03 343.22 0.01 2 4 8 GO:0005529 sugar binding MF 8.63e-03 32.74 0.13 3 38 9 GO:0002020 protease binding MF 0.01 97.90 0.03 2 9 18 module 18 7 0 3.5 2.5 3 13.00 10.62 945 946 947 948 949 950 951 952 953 23 0.54 0.62 1.00 0.64 0.54 0.60 0.85 0.73 0.55 0.54 89 93 107 88 0.66 1.00 0.92 0.62 1 9 1 GO:0006986 response to unfolded protein BP 4.31e-07 235.31 0.06 5 21 2 GO:0051789 response to protein stimulus BP 1.04e-05 113.45 0.11 5 38 3 GO:0009607 response to biotic stimulus BP 5.97e-03 28.32 0.39 5 133 4 GO:0006457 protein folding BP 7.14e-03 40.26 0.19 4 63 5 GO:0042026 protein refolding BP 8.49e-03 864.86 8.89e-03 2 3 6 GO:0051131 chaperone-mediated protein complex assembly BP 8.49e-03 864.86 8.89e-03 2 3 7 GO:0051082 unfolded protein binding MF 6.54e-04 51.85 0.15 4 51 19 module 19 8 0 3.5 2.5 1 15.48 10.62 439 251 204 416 203 1033 75 68 155 128 129 156 138 144 142 143 170 173 202 -0.89 -0.84 0.78 0.78 0.95 0.81 0.78 0.76 0.76 0.74 0.75 0.75 0.77 0.78 0.74 -1.00 -0.85 -0.87 0.81 69 57 97 102 25 103 -0.64 -0.78 -0.92 -1.00 -0.79 -0.90 13 16 29 33 34 38 42 47 48 49 54 55 58 61 62 63 70 20 module 20 7 0 3.5 2 2 13.42 13.39 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 997 998 999 1000 1001 1002 -0.56 -0.84 -0.94 -0.83 -0.86 -0.77 -0.83 -0.69 -1.00 -0.85 -0.81 -0.83 -0.82 -1.00 -0.88 -0.82 -0.55 -0.69 -0.78 0.63 -0.59 -0.61 36 79 68 67 70 25 -0.50 -0.96 -0.57 -0.99 -1.00 -0.86 14 15 1 GO:0009615 response to virus BP 4.75e-10 57.02 0.41 10 62 2 GO:0051707 response to other organism BP 1.11e-07 30.76 0.69 10 105 3 GO:0009607 response to biotic stimulus BP 1.19e-06 23.53 0.88 10 133 4 GO:0051704 multi-organism process BP 2.75e-06 17.44 1.65 12 251 5 GO:0050896 response to stimulus BP 6.91e-05 15.08 5.54 17 841 6 GO:0005062 hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity MF 0.02 181.24 0.02 2 4 1 04630 Jak-STAT signaling pathway 0.05 16.13 0.30 3 54 21 module 21 16 0 3.5 1.5 1 14.23 13.45 241 242 225 226 227 228 229 230 231 232 233 205 204 206 207 208 209 210 211 212 0.86 0.82 0.98 0.90 0.92 0.82 0.97 0.96 0.95 0.81 1.00 0.88 0.91 0.83 0.83 0.90 0.84 0.94 0.95 0.82 71 64 65 61 56 67 27 5 24 7 59 95 66 120 47 2 -0.83 -0.93 0.09 -0.92 0.08 0.45 -0.86 -0.97 -0.02 0.16 -0.92 -0.98 -1.00 0.04 -0.02 0.10 13 16 34 37 77 1 GO:0005576 extracellular region CC 1.81e-03 11.77 1.07 7 222 22 module 22 8 0 3.5 1.5 1 15.65 13.45 16 17 18 19 20 -0.94 -0.94 -1.00 -0.80 -0.67 51 30 42 27 5 28 29 91 41 95 127 124 103 62 59 -0.58 -0.62 -0.59 -0.61 -0.51 -0.67 -0.58 -1.00 -0.63 0.24 -0.49 0.15 0.20 -0.74 -0.55 25 44 23 module 23 8 0 3.5 1.5 2 24.25 13.45 394 342 343 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 340 392 393 347 348 349 350 345 363 364 395 -0.49 -0.52 -0.54 -0.57 -0.51 -0.77 -0.85 -0.68 -0.61 -0.68 -0.64 -0.84 -0.87 -0.83 -0.65 -0.65 -0.84 -0.83 -0.91 -0.90 -0.61 -1.00 -0.97 -0.90 -0.82 -0.81 -0.72 -0.93 -0.58 -0.90 -0.78 -0.58 -0.49 -0.51 -0.50 -0.47 -0.53 -0.61 -0.49 -0.51 -0.56 58 100 76 78 62 61 66 72 60 59 105 0.65 -0.34 -0.47 -0.45 -1.00 -0.65 -0.56 -0.51 -0.61 -1.00 -0.76 5 10 17 26 31 33 44 54 1 GO:0032781 positive regulation of ATPase activity BP 8.11e-04 Inf 0.03 3 3 2 GO:0043462 regulation of ATPase activity BP 3.21e-03 290.52 0.04 3 4 3 GO:0015669 gas transport BP 7.96e-03 145.21 0.06 3 5 4 GO:0006783 heme biosynthetic process BP 0.02 96.77 0.07 3 6 5 GO:0006779 porphyrin biosynthetic process BP 0.03 72.56 0.08 3 7 6 GO:0033014 tetrapyrrole biosynthetic process BP 0.03 72.56 0.08 3 7 7 GO:0042168 heme metabolic process BP 0.03 72.56 0.08 3 7 8 GO:0065008 regulation of biological quality BP 0.03 4.70 4.51 14 403 9 GO:0006778 porphyrin metabolic process BP 0.04 58.03 0.09 3 8 10 GO:0033013 tetrapyrrole metabolic process BP 0.04 58.03 0.09 3 8 11 GO:0008519 ammonium transmembrane transporter activity MF 0.02 Inf 0.02 2 2 12 GO:0015101 organic cation transmembrane transporter activity MF 0.02 Inf 0.02 2 2 13 GO:0030506 ankyrin binding MF 0.02 Inf 0.02 2 2 1 00860 Porphyrin and chlorophyll metabolism 7.94e-06 115.27 0.08 4 11 24 module 24 10 0 3.5 1.5 2 18.56 13.45 1065 1076 1066 1067 1070 1068 1069 1071 1072 1073 1074 1075 1063 1064 0.98 0.75 0.93 1.00 0.90 0.90 0.88 0.87 0.79 0.76 0.83 0.91 0.81 0.73 66 11 48 7 67 10 9 74 12 95 101 121 36 45 42 44 103 0.54 0.58 -0.48 0.62 0.82 -0.55 0.62 0.58 0.97 0.79 -0.51 -0.54 0.63 0.83 0.68 1.00 -0.51 28 38 42 55 56 57 58 59 61 62 63 1 GO:0006334 nucleosome assembly BP 2.86e-11 Inf 0.07 6 33 2 GO:0031497 chromatin assembly BP 3.35e-11 Inf 0.07 6 34 3 GO:0034728 nucleosome organization BP 5.57e-11 Inf 0.07 6 37 4 GO:0065004 protein-DNA complex assembly BP 5.57e-11 Inf 0.07 6 37 5 GO:0006323 DNA packaging BP 1.80e-10 Inf 0.09 6 45 6 GO:0006333 chromatin assembly or disassembly BP 4.87e-10 Inf 0.10 6 53 7 GO:0071103 DNA conformation change BP 5.24e-10 Inf 0.11 6 54 8 GO:0006325 chromatin organization BP 1.59e-07 Inf 0.27 6 137 9 GO:0034622 cellular macromolecular complex assembly BP 2.86e-07 Inf 0.30 6 152 10 GO:0034621 cellular macromolecular complex subunit organization BP 5.77e-07 Inf 0.34 6 172 11 GO:0051276 chromosome organization BP 7.21e-07 Inf 0.36 6 180 12 GO:0065003 macromolecular complex assembly BP 8.34e-06 Inf 0.54 6 272 13 GO:0043933 macromolecular complex subunit organization BP 1.23e-05 Inf 0.58 6 293 14 GO:0022607 cellular component assembly BP 2.04e-05 Inf 0.64 6 322 15 GO:0044085 cellular component biogenesis BP 3.10e-05 Inf 0.69 6 349 16 GO:0006996 organelle organization BP 1.47e-04 Inf 0.90 6 457 17 GO:0016043 cellular component organization BP 3.53e-03 Inf 1.55 6 785 18 GO:0042742 defense response to bacterium BP 4.80e-03 100.53 0.03 2 17 19 GO:0009617 response to bacterium BP 0.04 32.45 0.09 2 48 20 GO:0000786 nucleosome CC 1.58e-12 Inf 0.04 6 23 21 GO:0032993 protein-DNA complex CC 2.41e-11 Inf 0.07 6 35 22 GO:0000785 chromatin CC 8.17e-09 Inf 0.17 6 89 23 GO:0044427 chromosomal part CC 2.41e-07 Inf 0.30 6 156 24 GO:0005694 chromosome CC 5.07e-07 Inf 0.34 6 178 25 GO:0043228 non-membrane-bounded organelle CC 2.11e-03 Inf 1.37 6 714 26 GO:0043232 intracellular non-membrane-bounded organelle CC 2.11e-03 Inf 1.37 6 714 27 GO:0032991 macromolecular complex CC 9.52e-03 Inf 1.80 6 939 28 GO:0003677 DNA binding MF 1.75e-04 Inf 1.09 6 563 29 GO:0003676 nucleic acid binding MF 1.40e-03 Inf 1.60 6 825 1 05322 Systemic lupus erythematosus 6.94e-19 Inf 0.28 11 37 25 module 25 7 0 3.5 1 1 17.32 15.92 16 17 18 19 20 -0.95 -0.94 -1.00 -0.90 -0.79 51 30 42 27 5 28 29 91 41 95 127 124 103 62 59 16 36 89 50 43 86 32 38 14 125 107 63 54 110 114 47 119 92 52 -0.58 -0.62 -0.59 -0.61 -0.52 -0.67 -0.58 -1.00 -0.63 0.24 -0.49 0.14 0.20 -0.74 -0.55 -0.50 -0.42 0.06 -0.45 -0.41 0.08 0.05 -0.45 0.05 0.05 0.05 -0.39 0.14 0.08 0.04 0.05 0.11 0.14 0.08 22 44 26 module 26 8 0 3.5 1 2 30.68 15.92 394 365 366 367 368 369 370 371 383 384 385 386 387 388 389 390 391 340 372 373 374 375 376 377 378 379 380 381 382 392 393 342 343 346 341 339 0.54 0.50 0.54 0.76 0.87 0.52 0.55 0.70 0.99 1.00 0.88 0.83 0.85 0.70 0.93 0.52 1.00 0.81 0.72 0.99 0.95 0.85 0.90 0.80 0.84 0.97 0.93 0.92 0.54 0.54 0.50 0.81 0.61 0.48 0.80 0.52 51 124 19 110 106 27 38 43 4 100 122 61 76 78 62 66 72 105 60 59 58 11 85 15 46 33 88 8 70 18 95 101 111 96 -0.39 -0.44 -0.55 0.34 -0.48 -0.43 0.28 0.27 -0.44 0.43 0.28 0.68 0.56 0.52 1.00 0.58 0.54 0.81 0.66 0.96 -0.59 -0.52 -0.48 -0.42 0.33 -0.40 0.33 -0.42 -0.48 -0.49 -0.52 0.37 0.30 0.28 5 10 17 23 31 33 44 54 56 58 61 62 63 1 GO:0015669 gas transport BP 2.00e-05 481.12 0.05 4 5 2 GO:0006783 heme biosynthetic process BP 9.19e-03 115.58 0.06 3 6 3 GO:0006779 porphyrin biosynthetic process BP 0.02 86.65 0.07 3 7 4 GO:0033014 tetrapyrrole biosynthetic process BP 0.02 86.65 0.07 3 7 5 GO:0042168 heme metabolic process BP 0.02 86.65 0.07 3 7 6 GO:0065008 regulation of biological quality BP 0.02 5.45 3.85 13 403 7 GO:0006778 porphyrin metabolic process BP 0.03 69.30 0.08 3 8 8 GO:0033013 tetrapyrrole metabolic process BP 0.03 69.30 0.08 3 8 9 GO:0005833 hemoglobin complex CC 0.03 205.93 0.03 2 3 10 GO:0005344 oxygen transporter activity MF 0.01 Inf 0.02 2 2 11 GO:0008519 ammonium transmembrane transporter activity MF 0.01 Inf 0.02 2 2 12 GO:0015101 organic cation transmembrane transporter activity MF 0.01 Inf 0.02 2 2 13 GO:0030506 ankyrin binding MF 0.01 Inf 0.02 2 2 1 00860 Porphyrin and chlorophyll metabolism 1.31e-06 202.14 0.06 4 11 27 module 27 8 0 3.5 1 1 17.89 15.92 41 40 42 43 39 1.00 0.93 0.94 0.94 1.00 57 51 13 104 100 105 118 116 123 92 113 114 115 117 119 107 112 108 110 103 96 52 111 121 98 101 120 106 122 75 -0.35 -0.31 0.45 0.64 0.46 0.50 0.50 0.78 0.75 0.91 0.94 0.80 1.00 0.59 0.70 -0.32 0.47 0.66 0.74 0.57 0.56 0.49 0.44 0.60 0.67 0.42 0.54 0.57 0.47 -0.34 11 46 51 53 64 72 77 80 1 GO:0042110 T cell activation BP 4.07e-03 Inf 0.09 3 89 2 GO:0046649 lymphocyte activation BP 0.01 Inf 0.12 3 123 3 GO:0045321 leukocyte activation BP 0.02 Inf 0.14 3 139 4 GO:0001775 cell activation BP 0.02 Inf 0.15 3 151 5 GO:0042105 alpha-beta T cell receptor complex CC 7.02e-05 6236.00 2.88e-03 2 3 6 GO:0042101 T cell receptor complex CC 6.37e-04 1037.67 7.69e-03 2 8 7 GO:0043235 receptor complex CC 0.02 166.59 0.04 2 39 8 GO:0042609 CD4 receptor binding MF 0.05 Inf 9.67e-04 1 1 9 GO:0042610 CD8 receptor binding MF 0.05 Inf 9.67e-04 1 1 1 04660 T cell receptor signaling pathway 2.41e-04 Inf 0.12 3 57 2 05340 Primary immunodeficiency 1.83e-03 148.21 0.04 2 21 3 04640 Hematopoietic cell lineage 4.28e-03 75.14 0.08 2 39 28 module 28 9 0 3.5 1 2 21.46 15.92 1071 1072 1073 1074 1075 1065 1066 1067 1076 1077 1070 1068 1069 0.81 0.76 0.80 0.82 0.80 1.00 0.92 0.97 0.83 0.81 0.88 0.88 0.86 24 98 28 121 103 102 25 41 37 116 108 36 45 42 44 10 66 11 48 7 67 9 74 12 95 101 86 87 80 18 54 112 100 110 106 99 117 -0.41 -0.41 -0.28 -0.53 -0.52 -0.34 -0.32 0.44 0.44 0.43 0.54 0.62 0.85 0.67 1.00 -0.54 0.47 0.51 -0.42 0.64 0.76 0.64 0.51 0.91 0.70 -0.46 -0.29 0.47 -0.29 -0.29 -0.42 -0.29 -0.34 0.47 0.40 -0.43 -0.34 24 38 42 47 48 49 55 56 57 58 59 61 62 63 70 1 GO:0006334 nucleosome assembly BP 3.10e-09 Inf 0.05 5 33 2 GO:0031497 chromatin assembly BP 3.50e-09 Inf 0.06 5 34 3 GO:0034728 nucleosome organization BP 5.28e-09 Inf 0.06 5 37 4 GO:0065004 protein-DNA complex assembly BP 5.28e-09 Inf 0.06 5 37 5 GO:0006323 DNA packaging BP 1.37e-08 Inf 0.07 5 45 6 GO:0006333 chromatin assembly or disassembly BP 3.08e-08 Inf 0.09 5 53 7 GO:0071103 DNA conformation change BP 3.24e-08 Inf 0.09 5 54 8 GO:0006325 chromatin organization BP 3.66e-06 Inf 0.23 5 137 9 GO:0034622 cellular macromolecular complex assembly BP 5.90e-06 Inf 0.25 5 152 10 GO:0034621 cellular macromolecular complex subunit organization BP 1.05e-05 Inf 0.28 5 172 11 GO:0051276 chromosome organization BP 1.25e-05 Inf 0.30 5 180 12 GO:0065003 macromolecular complex assembly BP 9.47e-05 Inf 0.45 5 272 13 GO:0043933 macromolecular complex subunit organization BP 1.30e-04 Inf 0.48 5 293 14 GO:0022607 cellular component assembly BP 1.95e-04 Inf 0.53 5 322 15 GO:0044085 cellular component biogenesis BP 2.74e-04 Inf 0.57 5 349 16 GO:0006996 organelle organization BP 9.84e-04 Inf 0.75 5 457 17 GO:0016043 cellular component organization BP 0.01 Inf 1.29 5 785 18 GO:0000786 nucleosome CC 2.73e-10 Inf 0.04 5 23 19 GO:0032993 protein-DNA complex CC 2.50e-09 Inf 0.06 5 35 20 GO:0000785 chromatin CC 3.03e-07 Inf 0.14 5 89 21 GO:0044427 chromosomal part CC 4.98e-06 Inf 0.25 5 156 22 GO:0005694 chromosome CC 9.14e-06 Inf 0.29 5 178 23 GO:0043228 non-membrane-bounded organelle CC 9.28e-03 Inf 1.14 5 714 24 GO:0043232 intracellular non-membrane-bounded organelle CC 9.28e-03 Inf 1.14 5 714 25 GO:0032991 macromolecular complex CC 0.03 Inf 1.50 5 939 26 GO:0003677 DNA binding MF 9.70e-04 Inf 0.91 5 563 27 GO:0003676 nucleic acid binding MF 5.28e-03 Inf 1.33 5 825 1 05322 Systemic lupus erythematosus 3.65e-17 Inf 0.26 10 37 29 module 29 9 0 3 3 2 16.80 15.22 439 173 202 251 170 144 142 143 138 416 203 1033 75 68 155 128 129 156 172 136 74 132 137 133 992 1106 135 642 1088 204 213 1092 988 989 0.91 0.85 -0.83 0.83 0.77 -0.82 -0.74 1.00 -0.75 -0.76 -0.87 -0.67 -0.77 -0.79 -0.92 -0.69 -0.69 -0.74 -0.65 -0.66 -0.64 -0.66 -0.64 -0.66 -0.62 -0.70 -0.67 0.81 0.73 -0.82 0.75 0.74 0.77 0.80 57 97 102 103 0.80 0.92 1.00 0.87 13 16 19 33 34 38 42 45 47 48 49 54 55 58 60 61 62 63 70 82 30 module 30 8 0 3 2.5 1 13.75 13.63 243 92 99 3 114 67 2 4 5 6 7 8 10 1 -0.94 -0.86 -0.85 -0.86 -0.84 -0.83 -0.86 -0.92 -0.80 -0.88 -0.93 -1.00 -0.87 -1.00 33 41 40 42 -1.00 -0.90 -0.98 -0.84 7 8 12 39 40 41 42 43 45 55 56 57 58 59 61 62 63 70 82 1 GO:0046870 cadmium ion binding MF 1.48e-12 2315.25 0.03 6 7 2 GO:0005507 copper ion binding MF 7.88e-09 164.68 0.09 6 20 31 module 31 11 0 3 2 1 19.35 16.64 338 347 348 349 350 345 383 384 385 386 387 388 389 390 391 372 373 374 375 376 377 378 379 380 381 382 392 393 346 339 340 306 307 308 309 310 311 312 313 314 299 300 334 335 869 958 269 359 360 361 362 267 984 -0.66 -0.55 -0.43 -0.47 -0.57 -0.56 -0.85 -0.90 -1.00 -0.78 -0.65 -0.66 -0.87 -0.55 -0.80 -0.60 -0.71 -0.52 -0.45 -0.50 -0.56 -0.47 -0.69 -0.66 -0.74 -0.53 -0.51 -0.47 -0.51 -0.49 -0.91 -0.52 -0.49 -0.59 -0.57 -0.43 -0.66 -0.48 -0.47 -0.57 -0.74 -0.63 -0.42 -0.46 -0.51 -0.46 -0.47 -0.46 -0.47 -0.55 -0.44 -0.42 -0.44 76 78 62 61 105 -0.46 -0.40 -1.00 -0.48 -0.37 5 10 17 23 26 32 33 44 54 1 GO:0006935 chemotaxis BP 0.02 12.29 0.64 6 43 2 GO:0042330 taxis BP 0.02 12.29 0.64 6 43 3 GO:0019863 IgE binding MF 0.04 Inf 0.03 2 2 1 00860 Porphyrin and chlorophyll metabolism 6.29e-03 40.56 0.12 3 11 32 module 32 7 0 3 1.5 1 20.01 19.13 441 711 753 443 442 269 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 0.65 0.78 0.63 0.66 0.64 0.77 0.87 0.73 0.66 0.82 0.72 0.69 0.67 0.64 0.79 0.65 0.70 0.66 0.68 0.69 1.00 0.78 0.64 0.73 0.67 125 41 103 79 50 57 17 89 83 78 71 0.59 0.72 -0.35 0.62 0.68 0.73 0.65 0.65 -0.27 0.63 1.00 31 44 54 60 64 65 66 68 69 71 72 73 74 75 76 77 78 79 80 81 82 1 GO:0050794 regulation of cellular process BP 0.04 9.73 12.00 21 1585 2 GO:0003707 steroid hormone receptor activity MF 2.09e-03 97.11 0.06 3 8 3 GO:0004879 ligand-dependent nuclear receptor activity MF 4.39e-03 69.32 0.07 3 10 4 GO:0004872 receptor activity MF 0.03 7.26 1.37 7 193 5 GO:0004871 signal transducer activity MF 0.03 5.71 2.43 9 342 6 GO:0060089 molecular transducer activity MF 0.03 5.71 2.43 9 342 33 module 33 13 0 3 1 1 28.70 22.01 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 305 200 144 301 302 303 304 334 335 299 300 340 306 307 308 309 310 311 312 313 314 336 337 -0.63 -0.65 -0.61 -0.71 -0.79 -0.59 -0.63 -0.69 -0.70 -0.69 -0.66 -0.71 -0.60 -0.73 -0.78 -0.72 -0.61 -0.71 -0.65 -0.82 -0.64 -0.71 -0.70 -0.62 -0.69 -0.74 -0.65 -0.68 -0.60 -0.59 -0.75 -0.87 -0.89 -0.79 -0.89 -1.00 -1.00 -0.81 -0.93 -0.93 -0.93 -0.99 77 1 106 4 89 73 81 21 91 39 45 43 25 103 82 79 83 80 22 90 74 75 3 107 84 99 115 117 92 52 16 122 66 62 78 76 61 100 72 0.53 -0.11 0.47 0.57 -0.09 -0.09 0.46 0.50 -0.18 0.53 -0.12 -0.07 0.57 0.62 -0.18 0.55 -0.30 0.60 0.54 -0.19 0.55 0.52 0.58 0.64 -0.21 0.55 -0.14 0.49 -0.16 -0.28 -1.00 -0.37 0.55 -0.58 -0.17 -0.32 -0.29 -0.16 0.48 5 10 17 19 23 26 29 31 38 42 44 47 48 49 54 55 58 61 62 1 GO:0006952 defense response BP 1.57e-03 7.51 2.08 11 171 2 GO:0019835 cytolysis BP 0.04 52.85 0.10 3 8 3 GO:0006968 cellular defense response BP 0.05 21.27 0.26 4 21 4 GO:0005576 extracellular region CC 2.68e-08 11.78 2.49 16 222 5 GO:0044421 extracellular region part CC 3.43e-05 10.83 1.35 10 120 6 GO:0005615 extracellular space CC 7.11e-04 9.87 1.10 8 98 7 GO:0005578 proteinaceous extracellular matrix CC 0.01 18.84 0.28 4 25 8 GO:0031012 extracellular matrix CC 0.03 14.62 0.35 4 31 9 GO:0001533 cornified envelope CC 0.03 187.03 0.03 2 3 10 GO:0005509 calcium ion binding MF 2.11e-03 7.59 1.60 9 138 11 GO:0019863 IgE binding MF 0.02 Inf 0.02 2 2 1 04650 Natural killer cell mediated cytotoxicity 0.04 9.93 0.57 4 54 34 module 34 14 0 3 1 1 24.18 22.01 163 164 213 204 205 214 215 216 217 218 219 220 221 222 223 224 234 235 236 237 225 226 227 228 229 230 231 232 233 206 207 208 209 210 211 212 241 242 465 238 239 240 0.68 0.65 0.57 0.97 0.71 0.62 0.83 0.74 0.89 0.75 0.80 0.61 0.60 0.72 0.86 0.71 0.86 0.90 0.77 0.87 1.00 0.96 0.91 0.80 0.82 0.96 0.97 0.72 0.98 0.93 0.64 0.80 0.77 0.85 0.85 0.71 0.60 0.68 0.67 0.74 0.60 0.62 11 50 33 29 91 39 62 76 68 88 8 28 9 12 1 84 63 71 64 65 61 56 67 27 5 24 7 59 95 66 54 94 13 117 119 120 47 2 123 92 52 115 114 102 -0.75 -0.74 -0.78 -0.75 -0.79 -0.79 -0.17 -0.11 -0.17 -0.12 -0.11 -0.85 -0.12 -0.16 -0.77 -0.82 -0.11 -0.79 -0.90 0.02 -0.95 0.02 0.40 -0.91 -0.96 -0.10 0.18 -0.82 -0.94 -1.00 -0.82 -0.80 -0.10 -0.06 -0.13 5.73e-03 -0.07 0.05 -0.18 -0.20 -0.15 -0.20 -0.19 -0.81 13 16 19 21 29 37 38 42 49 55 64 72 77 1 GO:0005576 extracellular region CC 1.20e-04 7.83 2.35 12 222 1 00591 Linoleic acid metabolism 4.93e-03 Inf 0.02 2 2 2 00140 Steroid hormone biosynthesis 0.05 72.41 0.05 2 5 35 module 35 11 0 3 1 1 26.28 22.01 941 942 943 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 879 1028 0.80 0.80 0.80 0.80 0.83 0.91 0.84 0.92 0.83 0.90 0.87 0.87 0.78 0.81 0.74 0.84 0.80 0.80 0.89 0.88 0.87 0.83 0.87 1.00 0.85 0.79 0.87 0.84 0.80 89 45 71 73 46 81 68 86 8 59 28 29 24 93 75 53 54 109 112 113 108 111 99 103 117 119 121 96 52 110 98 31 94 13 106 118 125 2 36 48 69 -0.67 -0.59 -0.56 -0.78 -0.54 0.46 -0.66 -0.63 0.52 0.29 0.33 0.53 0.31 0.48 0.36 -0.63 -1.00 -0.72 0.51 0.64 0.55 0.46 0.52 0.38 0.37 0.65 0.50 0.54 0.43 0.79 0.48 -0.66 -0.51 -0.55 -0.53 -0.66 -0.51 -0.52 -0.52 0.28 -0.52 6 50 64 72 77 1 GO:0007049 cell cycle BP 1.62e-12 25.03 3.16 21 343 2 GO:0000279 M phase BP 8.24e-11 27.93 1.09 14 118 3 GO:0000280 nuclear division BP 1.34e-09 28.94 0.81 12 88 4 GO:0007067 mitosis BP 1.34e-09 28.94 0.81 12 88 5 GO:0048285 organelle fission BP 2.30e-09 27.46 0.85 12 92 6 GO:0000087 M phase of mitotic cell cycle BP 2.63e-09 27.11 0.86 12 93 7 GO:0022403 cell cycle phase BP 5.44e-09 19.75 1.47 14 159 8 GO:0022402 cell cycle process BP 4.90e-08 15.22 2.09 15 227 9 GO:0007017 microtubule-based process BP 2.13e-07 24.39 0.71 10 77 10 GO:0007051 spindle organization BP 2.16e-07 62.35 0.21 7 23 11 GO:0000226 microtubule cytoskeleton organization BP 2.17e-07 30.51 0.51 9 55 12 GO:0051301 cell division BP 5.10e-07 18.63 1.03 11 112 13 GO:0000278 mitotic cell cycle BP 8.22e-07 14.04 1.73 13 188 14 GO:0006260 DNA replication BP 1.30e-05 18.04 0.79 9 86 15 GO:0048015 phosphoinositide-mediated signaling BP 3.43e-05 38.81 0.25 6 27 16 GO:0006996 organelle organization BP 1.08e-04 7.76 4.21 16 457 17 GO:0006270 DNA replication initiation BP 2.06e-03 49.98 0.13 4 14 18 GO:0007010 cytoskeleton organization BP 2.47e-03 9.09 1.46 9 158 19 GO:0006261 DNA-dependent DNA replication BP 2.92e-03 24.01 0.30 5 32 20 GO:0051726 regulation of cell cycle BP 3.20e-03 10.16 1.12 8 122 21 GO:0019932 second-messenger-mediated signaling BP 6.18e-03 14.12 0.58 6 63 22 GO:0006268 DNA unwinding during replication BP 0.01 72.10 0.07 3 8 23 GO:0006259 DNA metabolic process BP 0.02 6.87 1.87 9 203 24 GO:0007346 regulation of mitotic cell cycle BP 0.02 14.99 0.44 5 48 25 GO:0032392 DNA geometric change BP 0.03 51.46 0.09 3 10 26 GO:0032508 DNA duplex unwinding BP 0.03 51.46 0.09 3 10 27 GO:0034501 protein localization to kinetochore BP 0.03 Inf 0.02 2 2 28 GO:0016043 cellular component organization BP 0.04 4.51 7.24 17 785 29 GO:0015630 microtubule cytoskeleton CC 3.56e-08 16.05 1.50 13 162 30 GO:0044430 cytoskeletal part CC 2.83e-05 9.31 2.14 12 230 31 GO:0005819 spindle CC 5.81e-05 18.61 0.55 7 59 32 GO:0005856 cytoskeleton CC 4.96e-04 6.47 3.33 13 358 33 GO:0043228 non-membrane-bounded organelle CC 5.25e-04 5.64 6.63 18 714 34 GO:0043232 intracellular non-membrane-bounded organelle CC 5.25e-04 5.64 6.63 18 714 35 GO:0000779 condensed chromosome, centromeric region CC 3.21e-03 27.33 0.20 4 22 36 GO:0000793 condensed chromosome CC 4.11e-03 15.51 0.43 5 46 37 GO:0044427 chromosomal part CC 4.54e-03 7.58 1.45 8 156 38 GO:0000775 chromosome, centromeric region CC 4.94e-03 14.78 0.45 5 48 39 GO:0005694 chromosome CC 0.01 6.55 1.65 8 178 40 GO:0005634 nucleus CC 0.01 4.76 13.03 23 1403 41 GO:0044428 nuclear part CC 0.02 4.01 6.20 15 667 42 GO:0005874 microtubule CC 0.03 9.86 0.64 5 69 43 GO:0005524 ATP binding MF 3.13e-06 9.20 4.14 17 459 44 GO:0032559 adenyl ribonucleotide binding MF 3.79e-06 9.06 4.20 17 465 45 GO:0030554 adenyl nucleotide binding MF 5.95e-06 8.74 4.32 17 479 46 GO:0001883 purine nucleoside binding MF 8.91e-06 8.46 4.44 17 492 47 GO:0001882 nucleoside binding MF 1.00e-05 8.37 4.48 17 496 48 GO:0032553 ribonucleotide binding MF 5.17e-05 7.32 4.99 17 553 49 GO:0032555 purine ribonucleotide binding MF 5.17e-05 7.32 4.99 17 553 50 GO:0017076 purine nucleotide binding MF 7.40e-05 7.09 5.12 17 567 51 GO:0000166 nucleotide binding MF 2.07e-04 6.46 6.21 18 688 52 GO:0003777 microtubule motor activity MF 0.02 33.41 0.13 3 14 53 GO:0004674 protein serine/threonine kinase activity MF 0.03 6.83 1.35 7 150 1 04110 Cell cycle 1.02e-08 34.59 0.84 10 75 2 03030 DNA replication 5.97e-05 33.37 0.27 5 24 36 module 36 13 0 3 1 1 25.96 22.01 900 901 990 995 909 910 911 912 577 976 426 427 913 914 0.87 0.88 0.90 1.00 0.94 0.93 0.87 0.92 0.91 0.88 0.91 0.96 0.90 0.93 11 31 66 13 109 107 112 113 108 110 114 111 99 115 103 117 119 121 98 96 52 97 125 104 100 101 120 105 124 106 116 118 122 123 92 128 2 102 94 72 80 6 126 74 89 73 82 76 88 77 32 10 14 19 84 95 0.71 0.66 0.66 -0.23 1.00 0.94 -0.32 -0.36 -0.27 -0.43 -0.40 -0.29 -0.37 -0.30 -0.56 -0.35 -0.44 -0.49 -0.40 -0.35 -0.27 0.89 0.91 -0.36 -0.26 -0.41 -0.25 -0.44 -0.50 -0.52 -0.31 -0.30 -0.36 -0.43 -0.31 -0.36 -0.31 -0.39 0.84 0.87 0.68 0.65 0.73 0.70 0.59 0.77 0.71 0.69 0.67 0.68 0.64 0.83 0.65 0.61 0.63 0.66 46 51 52 53 64 72 77 1 GO:0042613 MHC class II protein complex CC 0.02 138.04 0.02 2 7 1 05310 Asthma 3.41e-03 177.25 0.03 2 10 2 05320 Autoimmune thyroid disease 4.61e-03 141.60 0.03 2 12 3 05330 Allograft rejection 4.99e-03 128.64 0.04 2 13 4 04672 Intestinal immune network for IgA production 5.28e-03 117.83 0.04 2 14 5 05332 Graft-versus-host disease 5.48e-03 108.69 0.04 2 15 6 04940 Type I diabetes mellitus 5.56e-03 100.86 0.04 2 16 7 05416 Viral myocarditis 0.02 49.93 0.08 2 30 8 04514 Cell adhesion molecules (CAMs) 0.02 43.56 0.10 2 34 9 04612 Antigen processing and presentation 0.02 43.56 0.10 2 34 10 05322 Systemic lupus erythematosus 0.02 39.74 0.10 2 37 37 module 37 8 0 3 1 1 25.26 22.01 214 215 216 217 218 219 220 221 222 223 224 234 235 236 237 225 226 227 228 229 230 231 232 233 206 207 208 209 210 211 212 205 204 213 965 966 967 968 0.64 0.87 0.82 0.92 0.75 0.86 0.67 0.66 0.68 0.72 0.64 0.73 0.83 0.80 0.82 1.00 0.91 0.98 0.86 0.91 0.94 0.94 0.75 0.89 0.92 0.63 0.72 0.71 0.88 0.94 0.77 0.60 0.84 0.69 0.60 0.60 0.59 0.60 16 74 110 91 39 62 76 68 88 8 28 9 12 1 84 63 94 13 117 119 71 64 65 61 56 67 27 5 24 120 47 2 66 7 59 95 54 50 123 92 52 33 29 35 31 -0.19 -0.17 -0.75 -0.81 -0.84 -0.14 -0.11 -0.17 -0.11 -0.12 -0.83 -0.09 -0.17 -0.73 -0.80 -0.10 -0.77 -0.10 -0.09 -0.12 -0.81 -0.90 0.04 -0.89 0.04 0.44 -0.94 -0.97 -0.07 0.01 -0.02 0.06 -1.00 0.15 -0.82 -0.92 -0.80 -0.77 -0.18 -0.18 -0.18 -0.80 -0.79 -0.73 -0.15 13 16 21 34 38 42 49 55 1 GO:0005576 extracellular region CC 5.56e-05 8.66 2.20 12 222 1 00591 Linoleic acid metabolism 5.04e-03 Inf 0.02 2 2 2 00140 Steroid hormone biosynthesis 0.05 72.41 0.05 2 5 38 module 38 7 0 2.5 2 1 28.27 22.71 171 1048 439 147 146 988 989 148 149 150 151 152 153 54 173 198 168 169 251 1088 642 170 641 166 145 144 142 143 138 139 134 157 140 141 428 135 136 137 1106 1033 155 156 68 75 132 133 74 992 128 416 117 118 119 172 112 130 131 964 127 1077 201 203 129 154 165 167 1022 1076 977 199 1092 202 213 204 205 -0.55 -0.55 0.85 -0.54 -0.58 0.78 0.72 -0.57 -0.57 -0.54 0.70 0.71 0.69 -0.59 0.78 0.76 -0.60 0.69 0.84 0.77 0.81 0.84 -0.61 -0.63 -0.62 -0.75 -0.79 1.00 -0.77 -0.69 -0.54 -0.66 -0.75 -0.60 -0.61 -0.65 -0.63 -0.68 -0.69 -0.85 -0.78 -0.74 -0.77 -0.82 -0.69 -0.72 -0.67 -0.72 -0.79 -0.83 -0.66 -0.57 -0.66 -0.72 -0.69 -0.60 -0.53 -0.56 -0.55 -0.54 -0.68 -0.98 -0.83 -0.55 -0.61 -0.60 -0.58 -0.54 -0.61 0.71 0.78 -0.71 0.84 -0.74 -0.58 69 57 97 103 25 102 41 35 0.68 0.78 0.88 0.80 0.82 1.00 -0.52 -0.43 13 16 19 24 28 29 33 34 37 39 40 41 42 43 45 47 48 49 54 55 56 57 58 59 60 61 62 63 67 70 82 39 module 39 9 0 2.5 2 1 24.97 22.71 717 430 887 87 53 1061 888 1037 894 113 116 123 88 89 90 93 99 92 100 101 102 103 104 105 106 107 108 109 110 111 72 94 95 96 97 98 91 1034 112 992 129 128 74 964 165 1085 125 3 884 1046 243 470 -0.81 -0.76 -0.75 -0.78 -0.83 -0.78 -0.86 -0.84 -0.79 -0.76 -0.81 -0.84 -0.83 -0.79 -0.91 -0.82 -0.82 -0.94 -0.86 -0.86 -0.88 -0.78 -0.94 -0.77 -0.80 -0.82 -0.88 -0.94 -0.85 -0.83 -0.78 -0.78 -0.80 -0.77 -0.83 -0.88 -0.87 -0.82 -0.84 -0.78 -0.75 -0.75 -0.76 -0.76 -0.77 -0.79 -0.78 -0.87 -0.83 -0.82 -1.00 -0.75 108 45 43 44 42 40 41 35 36 38 -0.65 -0.77 -0.78 -0.83 -1.00 -0.90 -0.85 -0.76 -0.70 -0.62 30 38 40 41 42 43 45 47 48 49 55 56 57 58 59 60 61 62 63 70 76 81 82 1 04722 Neurotrophin signaling pathway 2.05e-03 8.82 1.34 8 66 2 05221 Acute myeloid leukemia 2.33e-03 13.28 0.67 6 33 3 05220 Chronic myeloid leukemia 0.02 8.88 0.93 6 46 40 module 40 8 0 2.5 2 1 28.22 22.71 1046 52 894 1061 888 1032 113 116 196 125 3 167 129 992 172 112 1034 91 97 98 94 95 96 99 100 101 102 103 104 105 106 107 108 109 110 111 72 92 93 123 88 89 90 438 76 85 86 87 905 53 1037 243 2 0.82 0.80 0.89 0.83 0.98 0.83 0.83 0.81 0.81 0.82 0.94 0.81 0.81 0.84 0.82 0.90 0.92 0.91 0.92 0.93 0.85 0.82 0.92 0.87 0.91 0.94 0.92 0.89 0.92 0.87 0.89 0.88 0.94 0.96 0.89 0.91 0.89 1.00 0.88 0.87 0.85 0.91 0.96 0.96 0.86 0.84 0.82 0.83 0.82 0.81 0.87 0.94 0.85 37 45 43 44 42 40 41 35 36 39 38 0.67 0.79 0.76 0.82 1.00 0.91 0.91 0.82 0.81 0.69 0.72 30 38 39 41 42 43 45 47 48 49 55 56 57 58 59 60 61 62 63 70 76 81 82 1 04722 Neurotrophin signaling pathway 0.04 7.48 1.11 6 66 41 module 41 12 0 2.5 2 1 26.97 22.71 1111 1052 434 243 961 167 992 396 1129 678 890 438 884 88 89 90 123 93 100 101 102 103 104 105 106 107 108 109 110 111 92 99 94 95 96 97 98 91 112 172 1034 72 76 85 86 87 1037 905 53 82 54 0.80 0.82 0.81 0.93 0.91 0.83 0.83 0.82 0.80 0.84 0.84 0.97 0.81 0.83 0.83 0.93 0.80 0.88 0.89 0.92 0.91 0.92 0.86 0.88 0.92 0.88 0.98 0.94 0.88 0.91 1.00 0.94 0.89 0.86 0.95 0.97 0.90 0.93 0.94 0.85 0.90 0.89 0.89 0.85 0.85 0.86 0.85 0.86 0.81 0.80 0.80 39 37 43 44 42 40 41 35 36 38 34 27 0.73 0.69 0.80 0.77 1.00 0.87 0.93 0.81 0.93 0.89 0.72 0.68 30 38 39 40 42 43 45 47 48 49 52 55 56 57 58 59 60 61 62 63 70 76 81 82 1 GO:0007005 mitochondrion organization BP 0.03 11.96 0.65 6 45 2 GO:0046982 protein heterodimerization activity MF 0.03 8.78 0.85 6 63 1 04722 Neurotrophin signaling pathway 5.64e-03 8.87 1.15 7 66 42 module 42 9 0 2.5 2 2 29.97 22.71 642 168 169 213 204 202 173 251 1088 1092 199 198 170 977 641 145 134 138 144 166 142 143 139 157 140 141 136 137 155 156 1033 135 1106 75 132 133 992 128 129 74 117 118 119 68 416 428 1077 112 130 131 172 964 127 201 962 1085 165 124 125 154 126 3 91 167 97 98 1034 1022 1023 203 1076 200 -0.74 0.57 -0.77 -0.77 0.69 0.69 -0.81 -0.80 -0.77 -0.80 -0.77 -0.80 -0.86 0.58 0.58 0.69 0.57 0.87 0.78 0.74 0.76 -0.97 0.68 0.69 0.70 0.62 0.63 0.70 0.85 0.78 0.79 0.70 0.74 0.90 0.77 0.74 0.78 0.85 0.82 0.76 0.68 0.64 0.65 0.88 0.81 0.69 0.60 0.73 0.64 0.59 0.78 0.61 0.63 0.66 0.58 0.61 0.62 0.61 0.57 0.56 0.57 0.58 0.59 0.61 0.59 0.57 0.64 0.58 0.58 1.00 0.63 0.60 97 57 103 25 43 44 42 40 41 35 102 -0.93 -0.82 -0.90 -0.92 0.28 0.32 0.31 0.29 0.39 0.30 -1.00 13 16 19 24 28 29 30 33 34 37 38 39 40 41 43 45 47 48 49 54 55 56 57 58 59 60 61 62 63 69 70 76 81 82 43 module 43 9 0 2.5 1.5 1 35.80 25.31 866 430 438 939 884 964 1037 894 113 116 123 88 89 90 100 101 102 103 104 105 106 107 108 109 110 111 72 92 99 94 95 96 97 98 91 1034 112 172 130 131 678 196 1129 114 76 93 115 1102 891 890 887 85 86 961 87 434 1103 243 0.79 0.77 0.83 0.73 0.78 0.74 0.81 0.75 0.81 0.76 0.74 0.74 0.77 0.77 0.87 0.85 0.86 0.87 0.83 0.84 0.85 0.85 0.91 0.91 0.76 0.83 0.83 1.00 0.87 0.79 0.82 0.92 0.89 0.89 0.83 0.83 0.88 0.80 0.75 0.76 0.79 0.77 0.80 0.78 0.83 0.80 0.74 0.81 0.75 0.81 0.81 0.77 0.78 0.78 0.81 0.76 0.75 0.86 27 116 108 45 43 44 42 40 41 35 36 37 38 39 34 126 91 33 0.71 0.77 0.76 0.81 0.88 0.89 1.00 0.95 0.94 0.86 0.92 0.77 0.86 0.81 0.72 0.66 0.69 0.62 30 38 39 40 41 42 45 47 48 49 55 56 57 58 59 60 61 62 63 70 76 81 82 1 04722 Neurotrophin signaling pathway 0.02 7.24 1.34 7 66 44 module 44 11 0 2.5 1.5 1 26.45 25.31 16 341 363 364 342 343 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 340 345 350 392 393 347 348 349 338 346 339 359 360 361 362 269 869 958 299 300 306 307 308 309 310 311 312 313 314 334 335 301 144 302 303 304 336 337 293 294 295 296 297 298 351 352 353 344 354 355 356 357 358 -0.37 -0.56 -0.39 -0.45 -0.59 -0.53 -0.42 -0.37 -0.48 -0.58 -0.46 -0.53 -0.46 -0.64 -0.83 -0.70 -0.63 -0.71 -0.65 -0.61 -0.80 -0.77 -0.80 -0.57 -0.88 -0.92 -0.93 -0.78 -0.74 -0.72 -0.87 -0.44 -0.85 -1.00 -0.50 -0.38 -0.56 -0.54 -0.51 -0.42 -0.39 -0.59 -0.47 -0.39 -0.55 -0.48 -0.48 -0.49 -0.51 -0.53 -0.41 -0.60 -0.64 -0.55 -0.62 -0.64 -0.67 -0.54 -0.76 -0.57 -0.61 -0.62 -0.47 -0.48 -0.40 -0.50 -0.45 -0.47 -0.42 -0.52 -0.53 -0.45 -0.39 -0.43 -0.42 -0.37 -0.38 -0.46 -0.46 -0.40 -0.44 -0.38 -0.38 -0.38 -0.40 -0.46 16 100 78 76 61 62 59 105 60 58 19 122 -0.39 -0.26 -0.35 -0.51 -0.56 -1.00 -0.38 -0.37 -0.28 0.69 0.58 -0.30 5 10 17 22 23 25 26 31 32 33 54 1 GO:0009611 response to wounding BP 1.03e-03 5.60 3.51 15 148 2 GO:0015669 gas transport BP 1.38e-03 174.35 0.12 4 5 3 GO:0006935 chemotaxis BP 4.84e-03 10.46 1.02 8 43 4 GO:0042330 taxis BP 4.84e-03 10.46 1.02 8 43 5 GO:0065008 regulation of biological quality BP 7.61e-03 3.41 9.55 24 403 6 GO:0009605 response to external stimulus BP 9.74e-03 4.14 5.29 17 223 7 GO:0032781 positive regulation of ATPase activity BP 0.01 Inf 0.07 3 3 8 GO:0007626 locomotory behavior BP 0.04 7.44 1.35 8 57 9 GO:0043462 regulation of ATPase activity BP 0.05 128.87 0.09 3 4 10 GO:0044421 extracellular region part CC 0.01 4.71 2.84 11 120 11 GO:0005576 extracellular region CC 0.02 3.49 5.26 15 222 12 GO:0008009 chemokine activity MF 9.42e-03 34.55 0.21 4 9 13 GO:0042379 chemokine receptor binding MF 0.02 28.78 0.24 4 10 14 GO:0050811 GABA receptor binding MF 0.03 63.93 0.12 3 5 1 04060 Cytokine-cytokine receptor interaction 0.04 6.90 1.15 6 53 45 module 45 8 0 2.5 1 1 39.36 27.64 73 396 961 678 87 85 86 76 72 100 101 102 103 104 105 106 107 108 109 110 111 93 92 99 94 95 96 97 98 91 1034 112 172 130 131 891 115 114 1102 890 196 1129 113 887 430 1037 1103 434 0.89 0.87 0.92 0.94 0.91 0.90 0.92 0.93 0.97 0.87 0.91 0.97 0.97 0.88 0.91 0.97 0.97 0.91 0.94 0.90 0.96 0.90 1.00 0.95 0.91 0.94 1.00 0.98 0.97 0.90 0.96 0.98 0.95 0.87 0.92 0.92 0.88 0.89 0.92 0.94 0.91 0.91 0.91 0.91 0.89 0.88 0.87 0.87 28 32 31 29 121 30 102 25 116 108 36 45 43 44 41 42 40 35 38 37 39 34 126 91 33 27 93 24 26 50 11 -0.48 -0.52 -0.47 0.54 -0.52 0.50 -0.48 -0.52 0.85 0.79 0.97 0.85 0.93 0.95 1.00 0.98 1.00 0.92 0.94 0.84 0.86 0.84 0.78 0.79 0.70 0.81 0.52 -0.43 -0.49 0.47 -0.42 29 30 38 39 40 41 42 43 47 48 49 55 56 57 58 59 60 61 62 63 70 76 81 82 46 module 46 14 0 2.5 1 1 37.49 27.64 1104 1047 990 560 561 562 563 564 565 1038 566 1113 464 1026 935 252 253 254 924 925 926 616 617 618 619 909 910 911 912 995 567 568 569 570 571 572 573 574 575 576 39 42 43 40 41 976 1107 895 49 50 981 -0.78 0.79 0.83 -0.78 -0.76 0.83 -0.79 0.79 -0.78 0.85 0.82 0.82 0.86 0.81 0.91 0.79 0.84 0.94 0.96 0.97 1.00 0.83 0.94 -0.82 0.89 0.82 0.97 0.88 0.97 0.85 -0.83 -0.78 -0.84 -0.86 -0.93 -0.82 -0.81 0.86 -0.81 0.81 -0.87 -0.93 -0.94 -0.88 -0.93 0.88 0.86 0.83 -0.80 -0.77 -0.81 13 102 97 125 128 109 101 120 106 122 116 92 111 121 98 112 108 96 115 114 110 103 117 119 107 52 113 104 105 118 124 99 123 100 2 47 51 66 -0.08 -0.14 0.97 0.99 -0.33 1.00 -0.40 -0.31 -0.49 -0.13 -0.34 -0.37 -0.19 -0.41 -0.54 -0.44 -0.47 -0.37 -0.47 -0.45 -0.66 -0.50 -0.52 -0.46 1.00 -0.40 -0.66 -0.43 -0.34 -0.16 -0.27 -0.12 -0.51 -0.17 -0.15 -0.07 0.89 0.88 11 27 36 51 52 53 64 65 66 68 69 71 72 73 74 76 77 78 80 1 GO:0002376 immune system process BP 1.33e-05 6.66 5.11 20 353 2 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II BP 5.33e-05 95.80 0.13 5 9 3 GO:0002684 positive regulation of immune system process BP 1.92e-04 11.29 1.25 10 86 4 GO:0006955 immune response BP 1.77e-03 6.00 3.33 14 230 5 GO:0001775 cell activation BP 5.14e-03 6.79 2.19 11 151 6 GO:0002682 regulation of immune system process BP 8.48e-03 7.10 1.87 10 129 7 GO:0019882 antigen processing and presentation BP 9.62e-03 22.44 0.32 5 22 8 GO:0045321 leukocyte activation BP 0.02 6.53 2.01 10 139 9 GO:0046649 lymphocyte activation BP 0.04 6.49 1.78 9 123 10 GO:0051251 positive regulation of lymphocyte activation BP 0.04 11.09 0.70 6 48 11 GO:0045059 positive thymic T cell selection BP 0.05 72.93 0.09 3 6 12 GO:0044459 plasma membrane part CC 1.70e-06 6.85 5.13 20 381 13 GO:0042101 T cell receptor complex CC 2.38e-06 138.60 0.11 5 8 14 GO:0005886 plasma membrane CC 4.71e-06 5.81 8.70 25 647 15 GO:0042613 MHC class II protein complex CC 1.20e-04 107.96 0.09 4 7 16 GO:0044425 membrane part CC 1.06e-03 4.06 12.20 26 907 17 GO:0042611 MHC protein complex CC 4.27e-03 29.37 0.20 4 15 18 GO:0016021 integral to membrane CC 7.94e-03 3.57 9.35 21 695 19 GO:0031224 intrinsic to membrane CC 0.01 3.50 9.50 21 706 20 GO:0043235 receptor complex CC 0.02 12.11 0.52 5 39 21 GO:0004888 transmembrane receptor activity MF 1.72e-03 8.10 1.48 9 115 22 GO:0004871 signal transducer activity MF 8.13e-03 4.49 4.41 14 342 23 GO:0060089 molecular transducer activity MF 8.13e-03 4.49 4.41 14 342 1 05310 Asthma 5.13e-04 44.41 0.17 4 10 2 05340 Primary immunodeficiency 6.33e-04 21.70 0.37 5 21 3 05320 Autoimmune thyroid disease 1.12e-03 33.26 0.21 4 12 4 05330 Allograft rejection 1.55e-03 29.54 0.23 4 13 5 04672 Intestinal immune network for IgA production 2.07e-03 26.57 0.24 4 14 6 05332 Graft-versus-host disease 2.71e-03 24.14 0.26 4 15 7 04940 Type I diabetes mellitus 3.45e-03 22.11 0.28 4 16 8 04612 Antigen processing and presentation 6.15e-03 11.86 0.59 5 34 9 04660 T cell receptor signaling pathway 8.47e-03 8.38 1.00 6 57 10 04640 Hematopoietic cell lineage 0.01 10.08 0.68 5 39 11 05416 Viral myocarditis 0.04 10.10 0.52 4 30 47 module 47 24 0 2.5 1 1 30.09 27.64 54 115 891 91 1085 1034 962 1077 134 157 428 140 141 136 137 135 1106 1033 155 156 68 75 203 416 128 129 132 133 74 117 118 119 130 131 172 112 992 142 143 139 166 145 144 138 170 642 1088 1079 -0.63 -0.62 -0.62 -0.64 -0.66 -0.65 -0.62 -0.65 -0.62 -0.69 -0.73 -0.69 -0.67 -0.63 -0.67 -0.67 -0.74 -0.78 -0.76 -0.81 -0.93 -0.92 -1.00 -0.72 -0.88 -0.85 -0.71 -0.81 -0.67 -0.67 -0.64 -0.66 -0.63 -0.66 -0.74 -0.74 -0.77 -0.87 0.89 -0.68 -0.79 -0.78 -0.70 -0.91 0.85 0.83 0.82 0.82 111 32 31 29 30 121 33 126 91 39 45 43 44 41 40 42 35 36 38 37 34 116 108 25 102 103 97 57 69 10 0.71 0.58 0.61 0.05 -0.06 0.64 0.07 -0.06 0.03 -6.18e-03 -0.17 -0.18 -0.24 -0.28 -0.17 -0.20 -0.20 -0.03 -0.07 -0.03 -8.01e-03 -0.16 -0.09 0.93 1.00 0.94 0.96 0.82 0.74 0.56 13 19 28 29 33 38 39 40 41 42 43 45 48 49 54 55 56 57 58 59 60 61 62 63 70 76 81 82 48 module 48 12 0 2.5 1 1 34.04 27.64 642 54 1048 201 641 145 166 144 142 143 138 139 1077 428 134 157 140 141 136 137 1106 135 155 156 1033 416 203 68 129 75 128 74 132 133 992 172 112 130 131 117 118 119 127 964 962 1034 124 1085 91 165 878 678 160 891 72 -0.85 0.69 0.65 0.68 0.65 0.76 0.77 0.72 0.85 -0.96 0.85 0.71 0.68 0.73 0.67 0.67 0.80 0.73 0.69 0.72 0.79 0.73 0.79 0.86 0.81 0.75 1.00 0.91 0.90 0.93 0.89 0.76 0.79 0.85 0.85 0.80 0.81 0.66 0.68 0.70 0.70 0.72 0.67 0.68 0.64 0.72 0.66 0.64 0.66 0.65 0.66 0.67 0.63 0.64 0.66 28 30 121 32 31 29 33 91 108 126 116 34 39 37 38 36 35 40 42 41 44 43 45 25 103 102 97 57 69 111 17 -0.54 0.09 -0.60 -0.55 -0.56 5.83e-03 -0.04 0.03 0.14 0.10 0.18 0.07 0.04 0.09 0.11 0.09 0.24 0.20 0.21 0.32 0.26 0.21 0.18 -0.90 -0.89 -1.00 -0.95 -0.83 -0.73 -0.65 -0.57 13 19 28 29 33 38 39 40 41 42 43 45 47 49 54 55 56 57 58 59 60 61 62 63 70 82 1 05221 Acute myeloid leukemia 0.01 11.70 0.60 5 33 49 module 49 13 0 2.5 1 1 29.67 27.64 439 251 170 642 139 166 145 144 142 143 138 1033 155 156 75 135 1106 136 137 140 141 157 134 1077 203 428 68 74 112 129 992 128 416 132 133 117 118 119 130 131 172 1034 678 964 878 962 127 201 641 54 1048 996 429 1079 1088 204 0.76 0.76 0.85 0.90 -0.75 -0.76 -0.74 -0.74 -0.86 0.98 -0.87 -0.81 -0.78 -0.83 -0.91 -0.70 -0.75 -0.67 -0.69 -0.79 -0.69 -0.65 -0.62 -0.61 -1.00 -0.73 -0.90 -0.70 -0.74 -0.86 -0.81 -0.87 -0.70 -0.75 -0.81 -0.68 -0.64 -0.69 -0.61 -0.60 -0.74 -0.63 -0.59 -0.63 -0.59 -0.60 -0.60 -0.63 -0.60 -0.63 -0.60 -0.61 0.75 0.74 0.80 -0.59 111 121 30 32 31 29 33 91 126 116 108 34 37 38 39 36 35 40 42 44 43 45 41 25 102 103 97 57 69 17 0.70 0.65 -0.02 0.61 0.63 0.08 0.11 0.05 -0.02 -0.10 -0.05 0.02 -5.50e-03 -0.03 0.02 -0.01 -0.16 -0.13 -0.14 -0.18 -0.13 -0.11 -0.23 0.92 1.00 0.91 0.96 0.84 0.76 0.60 13 16 19 28 29 33 34 37 38 39 40 41 42 43 45 47 48 54 55 56 57 58 59 60 61 62 63 70 82 50 module 50 18 0 2.5 1 1 29.47 27.64 941 942 943 1028 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 879 669 490 491 492 493 475 1109 476 973 477 478 479 480 481 482 483 484 485 486 487 488 489 -0.77 -0.86 -0.93 -0.72 -0.77 -0.72 -0.86 -0.90 -0.97 -0.90 -0.86 -0.86 -0.86 -0.87 -0.81 -0.83 -0.92 -0.80 -0.75 -0.81 -0.96 -0.94 -0.86 -0.89 -1.00 -0.80 -0.73 -0.81 -0.85 0.75 -0.83 -0.76 -0.71 -0.78 -0.75 -0.89 -0.71 -0.70 -0.72 -0.70 -0.77 -0.74 -0.73 -0.74 -0.73 0.79 -0.76 -0.74 -0.79 -0.71 -0.74 45 71 73 81 86 59 28 24 93 75 53 31 94 13 106 118 110 98 109 112 108 111 121 96 99 113 103 117 119 52 107 114 54 46 89 68 8 29 30 34 4 95 0.64 0.66 0.82 -0.17 0.70 -0.14 -0.07 -0.16 -0.29 -0.06 0.68 0.75 0.62 0.58 0.67 0.70 -0.49 -0.12 0.76 -0.23 -0.26 -0.12 -0.15 -0.21 -0.30 -0.42 -0.20 -0.18 -0.43 -0.27 0.64 -0.07 1.00 0.67 0.78 0.71 -0.37 -0.38 -0.06 -0.11 -0.08 0.62 6 35 64 66 68 72 75 77 79 1 GO:0007049 cell cycle BP 2.68e-19 19.65 5.53 34 343 2 GO:0000279 M phase BP 6.16e-18 26.94 1.90 23 118 3 GO:0022403 cell cycle phase BP 1.86e-17 22.19 2.57 25 159 4 GO:0022402 cell cycle process BP 5.93e-16 17.11 3.66 27 227 5 GO:0000280 nuclear division BP 4.50e-15 26.79 1.42 19 88 6 GO:0007067 mitosis BP 4.50e-15 26.79 1.42 19 88 7 GO:0048285 organelle fission BP 1.11e-14 25.29 1.48 19 92 8 GO:0000087 M phase of mitotic cell cycle BP 1.38e-14 24.94 1.50 19 93 9 GO:0000278 mitotic cell cycle BP 3.64e-13 15.13 3.03 23 188 10 GO:0006260 DNA replication BP 1.76e-12 22.47 1.39 17 86 11 GO:0007051 spindle organization BP 2.61e-10 58.68 0.37 10 23 12 GO:0000226 microtubule cytoskeleton organization BP 4.76e-10 25.33 0.89 13 55 13 GO:0007017 microtubule-based process BP 2.63e-09 18.57 1.24 14 77 14 GO:0051301 cell division BP 2.83e-09 14.61 1.81 16 112 15 GO:0006259 DNA metabolic process BP 3.84e-08 9.65 3.28 19 203 16 GO:0006996 organelle organization BP 2.47e-07 6.71 7.37 26 457 17 GO:0007059 chromosome segregation BP 5.76e-07 27.79 0.53 9 33 18 GO:0051726 regulation of cell cycle BP 1.61e-06 10.67 1.97 14 122 19 GO:0010564 regulation of cell cycle process BP 3.74e-06 21.46 0.65 9 40 20 GO:0006261 DNA-dependent DNA replication BP 1.15e-05 24.10 0.52 8 32 21 GO:0006270 DNA replication initiation BP 2.02e-05 51.98 0.23 6 14 22 GO:0007346 regulation of mitotic cell cycle BP 2.07e-05 17.01 0.77 9 48 23 GO:0030071 regulation of mitotic metaphase/anaphase transition BP 6.12e-05 84.77 0.15 5 9 24 GO:0048015 phosphoinositide-mediated signaling BP 7.29e-05 24.73 0.44 7 27 25 GO:0007093 mitotic cell cycle checkpoint BP 1.18e-04 34.60 0.29 6 18 26 GO:0007091 mitotic metaphase/anaphase transition BP 1.20e-04 67.80 0.16 5 10 27 GO:0071174 mitotic cell cycle spindle checkpoint BP 1.69e-04 265.51 0.08 4 5 28 GO:0007010 cytoskeleton organization BP 3.66e-04 7.08 2.55 13 158 29 GO:0000075 cell cycle checkpoint BP 4.96e-04 17.62 0.56 7 35 30 GO:0031577 spindle checkpoint BP 4.97e-04 132.71 0.10 4 6 31 GO:0006974 response to DNA damage stimulus BP 8.07e-04 7.13 2.29 12 142 32 GO:0016043 cellular component organization BP 1.58e-03 3.93 12.67 28 785 33 GO:0000070 mitotic sister chromatid segregation BP 2.68e-03 28.18 0.27 5 17 34 GO:0000819 sister chromatid segregation BP 2.68e-03 28.18 0.27 5 17 35 GO:0007088 regulation of mitosis BP 2.68e-03 28.18 0.27 5 17 36 GO:0051783 regulation of nuclear division BP 2.68e-03 28.18 0.27 5 17 37 GO:0006281 DNA repair BP 3.33e-03 7.48 1.76 10 109 38 GO:0010948 negative regulation of cell cycle process BP 6.54e-03 44.18 0.16 4 10 39 GO:0007094 mitotic cell cycle spindle assembly checkpoint BP 8.72e-03 194.80 0.06 3 4 40 GO:0045839 negative regulation of mitosis BP 8.72e-03 194.80 0.06 3 4 41 GO:0045841 negative regulation of mitotic metaphase/anaphase transition BP 8.72e-03 194.80 0.06 3 4 42 GO:0051784 negative regulation of nuclear division BP 8.72e-03 194.80 0.06 3 4 43 GO:0007052 mitotic spindle organization BP 0.01 33.11 0.19 4 12 44 GO:0090068 positive regulation of cell cycle process BP 0.01 33.11 0.19 4 12 45 GO:0050000 chromosome localization BP 0.02 97.37 0.08 3 5 46 GO:0051303 establishment of chromosome localization BP 0.02 97.37 0.08 3 5 47 GO:0051983 regulation of chromosome segregation BP 0.02 97.37 0.08 3 5 48 GO:0071173 spindle assembly checkpoint BP 0.02 97.37 0.08 3 5 49 GO:0051656 establishment of organelle localization BP 0.02 16.06 0.42 5 26 50 GO:0019932 second-messenger-mediated signaling BP 0.03 8.73 1.02 7 63 51 GO:0051640 organelle localization BP 0.04 14.03 0.47 5 29 52 GO:0033554 cellular response to stress BP 0.05 4.52 3.42 12 212 53 GO:0015630 microtubule cytoskeleton CC 6.54e-14 15.88 2.65 22 162 54 GO:0005694 chromosome CC 8.78e-11 11.89 2.91 20 178 55 GO:0044430 cytoskeletal part CC 1.20e-09 9.59 3.76 21 230 56 GO:0005819 spindle CC 6.61e-09 19.80 0.96 12 59 57 GO:0044427 chromosomal part CC 1.21e-08 10.55 2.55 17 156 58 GO:0043228 non-membrane-bounded organelle CC 1.63e-08 6.43 11.66 33 714 59 GO:0043232 intracellular non-membrane-bounded organelle CC 1.63e-08 6.43 11.66 33 714 60 GO:0000228 nuclear chromosome CC 5.32e-08 15.98 1.14 12 70 61 GO:0000779 condensed chromosome, centromeric region CC 8.34e-08 40.62 0.36 8 22 62 GO:0000793 condensed chromosome CC 1.51e-07 20.56 0.75 10 46 63 GO:0005856 cytoskeleton CC 7.81e-07 6.18 5.85 22 358 64 GO:0000922 spindle pole CC 9.26e-07 40.55 0.31 7 19 65 GO:0044454 nuclear chromosome part CC 1.13e-06 16.04 0.91 10 56 66 GO:0000777 condensed chromosome kinetochore CC 1.38e-06 37.42 0.33 7 20 67 GO:0000775 chromosome, centromeric region CC 4.20e-06 16.66 0.78 9 48 68 GO:0005815 microtubule organizing center CC 3.37e-05 10.61 1.29 10 79 69 GO:0000776 kinetochore CC 5.01e-05 19.38 0.52 7 32 70 GO:0044428 nuclear part CC 5.74e-05 4.27 10.90 27 667 71 GO:0005634 nucleus CC 8.81e-05 4.56 22.92 40 1403 72 GO:0005657 replication fork CC 6.75e-04 25.57 0.29 5 18 73 GO:0030894 replisome CC 7.20e-04 52.19 0.15 4 9 74 GO:0043596 nuclear replication fork CC 7.20e-04 52.19 0.15 4 9 75 GO:0043601 nuclear replisome CC 7.20e-04 52.19 0.15 4 9 76 GO:0005874 microtubule CC 1.05e-03 9.18 1.13 8 69 77 GO:0005658 alpha DNA polymerase:primase complex CC 1.50e-03 191.88 0.07 3 4 78 GO:0005813 centrosome CC 1.82e-03 10.24 0.88 7 54 79 GO:0043234 protein complex CC 3.56e-03 3.25 12.58 26 770 80 GO:0000780 condensed nuclear chromosome, centromeric region CC 3.57e-03 95.91 0.08 3 5 81 GO:0000940 outer kinetochore of condensed chromosome CC 6.99e-03 63.92 0.10 3 6 82 GO:0044446 intracellular organelle part CC 8.08e-03 3.13 22.38 36 1370 83 GO:0044422 organelle part CC 9.43e-03 3.09 22.53 36 1379 84 GO:0030496 midbody CC 0.01 47.92 0.11 3 7 85 GO:0000794 condensed nuclear chromosome CC 0.01 18.58 0.29 4 18 86 GO:0032993 protein-DNA complex CC 0.02 11.02 0.57 5 35 87 GO:0031981 nuclear lumen CC 0.02 3.05 8.49 19 520 88 GO:0005654 nucleoplasm CC 0.03 3.28 5.90 15 361 89 GO:0005814 centriole CC 0.05 23.93 0.18 3 11 90 GO:0005876 spindle microtubule CC 0.05 23.93 0.18 3 11 91 GO:0001882 nucleoside binding MF 1.06e-03 4.07 7.83 21 496 92 GO:0005524 ATP binding MF 1.28e-03 4.11 7.25 20 459 93 GO:0032559 adenyl ribonucleotide binding MF 1.56e-03 4.04 7.35 20 465 94 GO:0032553 ribonucleotide binding MF 1.57e-03 3.87 8.74 22 553 95 GO:0032555 purine ribonucleotide binding MF 1.57e-03 3.87 8.74 22 553 96 GO:0017076 purine nucleotide binding MF 2.36e-03 3.75 8.96 22 567 97 GO:0030554 adenyl nucleotide binding MF 2.41e-03 3.90 7.57 20 479 98 GO:0001883 purine nucleoside binding MF 3.62e-03 3.77 7.77 20 492 99 GO:0000166 nucleotide binding MF 4.74e-03 3.45 10.87 24 688 1 04110 Cell cycle 9.51e-12 30.87 1.26 14 75 2 03030 DNA replication 4.41e-10 55.64 0.40 9 24 3 04114 Oocyte meiosis 2.39e-03 10.08 0.86 6 51 4 04914 Progesterone-mediated oocyte maturation 0.05 8.59 0.60 4 36 5 00240 Pyrimidine metabolism 0.05 8.32 0.62 4 37 51 module 51 11 0 2.5 1 1 39.73 27.64 48 893 921 922 923 426 427 577 578 579 580 581 582 567 568 569 570 571 572 573 574 575 576 995 909 910 911 912 616 617 618 619 924 925 926 935 1026 464 1113 1038 252 253 254 42 43 40 41 39 895 1107 976 1047 -0.79 0.80 0.81 0.87 0.81 0.80 0.78 0.77 0.80 0.77 0.78 -0.80 0.80 -0.80 -0.85 -0.82 -0.88 -0.81 -0.83 -0.85 0.85 -0.85 0.83 0.88 0.88 0.96 0.87 0.96 0.87 0.93 -0.83 0.90 0.94 0.97 1.00 0.84 0.80 0.86 0.85 0.85 0.81 0.84 0.90 -0.90 -0.93 -0.86 -0.88 -0.83 0.85 0.87 0.90 0.80 72 94 102 97 125 109 99 128 2 111 121 98 101 120 106 122 112 108 96 116 92 115 100 104 105 118 113 117 103 107 52 119 114 110 123 124 47 31 0.88 0.87 -0.19 0.92 0.91 1.00 -0.32 -0.37 -0.24 -0.26 -0.49 -0.58 -0.43 -0.37 -0.52 -0.25 -0.48 -0.49 -0.42 -0.42 -0.40 -0.45 -0.22 -0.46 -0.42 -0.20 -0.67 -0.56 -0.49 0.97 -0.39 -0.53 -0.49 -0.66 -0.53 -0.41 -0.22 0.89 11 27 36 46 52 53 64 65 66 68 69 71 72 73 74 76 77 78 80 1 GO:0002376 immune system process BP 9.45e-06 6.95 5.00 20 353 2 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II BP 5.50e-05 98.36 0.13 5 9 3 GO:0002684 positive regulation of immune system process BP 1.77e-04 11.63 1.22 10 86 4 GO:0006955 immune response BP 2.23e-04 6.92 3.26 15 230 5 GO:0019882 antigen processing and presentation BP 3.59e-04 30.18 0.31 6 22 6 GO:0001775 cell activation BP 6.02e-04 7.95 2.14 12 151 7 GO:0045321 leukocyte activation BP 2.05e-03 7.70 1.97 11 139 8 GO:0051251 positive regulation of lymphocyte activation BP 3.32e-03 14.00 0.68 7 48 9 GO:0002696 positive regulation of leukocyte activation BP 5.05e-03 13.04 0.72 7 51 10 GO:0046649 lymphocyte activation BP 5.12e-03 7.73 1.74 10 123 11 GO:0050867 positive regulation of cell activation BP 6.57e-03 12.46 0.75 7 53 12 GO:0002682 regulation of immune system process BP 7.87e-03 7.32 1.83 10 129 13 GO:0050870 positive regulation of T cell activation BP 0.01 14.55 0.55 6 39 14 GO:0051249 regulation of lymphocyte activation BP 0.02 10.59 0.86 7 61 15 GO:0002694 regulation of leukocyte activation BP 0.02 10.02 0.91 7 64 16 GO:0042110 T cell activation BP 0.02 8.22 1.26 8 89 17 GO:0002768 immune response-regulating cell surface receptor signaling pathway BP 0.03 17.78 0.38 5 27 18 GO:0032946 positive regulation of mononuclear cell proliferation BP 0.03 17.78 0.38 5 27 19 GO:0050671 positive regulation of lymphocyte proliferation BP 0.03 17.78 0.38 5 27 20 GO:0070665 positive regulation of leukocyte proliferation BP 0.03 17.78 0.38 5 27 21 GO:0050865 regulation of cell activation BP 0.03 9.67 0.93 7 66 22 GO:0050778 positive regulation of immune response BP 0.04 11.68 0.67 6 47 23 GO:0030098 lymphocyte differentiation BP 0.04 9.05 0.99 7 70 24 GO:0044459 plasma membrane part CC 8.26e-06 6.02 5.49 20 381 25 GO:0005886 plasma membrane CC 1.67e-04 4.50 9.33 24 647 26 GO:0042613 MHC class II protein complex CC 1.80e-04 99.97 0.10 4 7 27 GO:0042611 MHC protein complex CC 1.87e-04 38.34 0.22 5 15 28 GO:0042101 T cell receptor complex CC 3.52e-04 74.95 0.12 4 8 29 GO:0044425 membrane part CC 1.82e-03 3.74 13.07 27 907 30 GO:0004871 signal transducer activity MF 4.14e-04 5.37 4.52 16 342 31 GO:0060089 molecular transducer activity MF 4.14e-04 5.37 4.52 16 342 32 GO:0004888 transmembrane receptor activity MF 1.95e-03 7.84 1.52 9 115 33 GO:0004872 receptor activity MF 0.02 5.07 2.55 10 193 1 05320 Autoimmune thyroid disease 4.84e-05 45.32 0.23 5 12 2 05330 Allograft rejection 7.57e-05 39.63 0.25 5 13 3 05332 Graft-versus-host disease 1.68e-04 31.66 0.28 5 15 4 04940 Type I diabetes mellitus 2.35e-04 28.76 0.30 5 16 5 05310 Asthma 7.27e-04 40.49 0.19 4 10 6 04612 Antigen processing and presentation 8.53e-04 14.03 0.64 6 34 7 05340 Primary immunodeficiency 9.44e-04 19.70 0.40 5 21 8 04672 Intestinal immune network for IgA production 3.02e-03 24.23 0.26 4 14 9 05416 Viral myocarditis 5.55e-03 12.53 0.57 5 30 10 04514 Cell adhesion molecules (CAMs) 9.97e-03 10.77 0.64 5 34 11 04640 Hematopoietic cell lineage 0.02 9.15 0.74 5 39 52 module 52 20 0 2.5 1 1 35.41 27.64 1052 870 908 907 13 424 425 614 615 587 588 921 922 923 577 616 617 618 619 935 924 925 926 909 910 911 912 976 913 914 915 916 917 918 919 920 -0.75 -0.82 -0.73 -0.72 -0.74 -0.72 -0.75 0.79 -0.71 -0.77 -0.74 -0.74 -0.72 -0.72 -0.73 -0.87 -0.82 0.78 -0.84 -0.70 -0.76 -0.78 -0.80 -0.75 -0.79 -0.72 -0.80 -1.00 -0.85 -0.74 -0.75 -0.76 -0.72 -0.76 -0.76 -0.79 6 74 126 80 72 94 125 101 120 106 122 112 92 128 104 100 105 124 118 123 2 107 113 110 114 99 115 117 119 52 103 96 109 111 121 98 97 108 116 102 25 35 36 34 38 27 30 22 -0.82 -0.77 -0.90 -0.71 -0.74 -0.84 -0.89 0.42 0.36 0.50 0.29 0.40 0.21 0.33 0.32 0.17 0.40 0.47 0.25 0.42 0.22 -0.87 0.50 0.55 0.35 0.26 0.35 0.47 0.38 0.31 0.56 0.34 -1.00 0.21 0.55 0.46 -0.88 0.23 0.16 0.49 0.23 -0.87 -0.89 -0.97 -0.91 -0.99 -0.84 -0.77 36 41 46 51 53 55 58 59 61 62 63 64 70 71 72 74 77 80 1 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II BP 1.38e-05 133.93 0.10 5 9 2 GO:0019882 antigen processing and presentation BP 6.88e-05 41.50 0.24 6 22 3 GO:0006955 immune response BP 2.32e-03 7.30 2.50 12 230 4 GO:0002376 immune system process BP 0.04 5.09 3.84 13 353 5 GO:0042611 MHC protein complex CC 3.41e-05 54.98 0.16 5 15 6 GO:0042613 MHC class II protein complex CC 4.47e-05 141.89 0.07 4 7 7 GO:0044459 plasma membrane part CC 1.47e-03 5.47 4.03 14 381 8 GO:0004871 signal transducer activity MF 8.53e-03 5.25 3.42 12 342 9 GO:0060089 molecular transducer activity MF 8.53e-03 5.25 3.42 12 342 1 05310 Asthma 1.24e-04 66.95 0.13 4 10 2 05320 Autoimmune thyroid disease 2.79e-04 50.14 0.15 4 12 3 05330 Allograft rejection 3.88e-04 44.54 0.16 4 13 4 04672 Intestinal immune network for IgA production 5.22e-04 40.06 0.18 4 14 5 05332 Graft-versus-host disease 6.84e-04 36.39 0.19 4 15 6 04940 Type I diabetes mellitus 8.76e-04 33.33 0.20 4 16 7 04612 Antigen processing and presentation 1.12e-03 18.34 0.43 5 34 8 05416 Viral myocarditis 0.01 15.23 0.38 4 30 9 04514 Cell adhesion molecules (CAMs) 0.02 13.16 0.43 4 34 10 05322 Systemic lupus erythematosus 0.02 11.94 0.47 4 37 53 module 53 19 0 2.5 1 1 45.86 27.64 587 588 1019 1020 1021 976 895 426 427 893 921 922 923 1107 577 578 579 580 581 582 567 568 569 570 571 572 573 574 575 576 39 40 41 995 909 910 911 912 616 617 618 619 935 924 925 926 42 43 252 253 254 1038 1113 464 1026 566 981 583 584 585 586 49 50 913 -0.80 -0.81 0.78 0.79 0.80 -0.92 -0.89 -0.83 -0.86 -0.84 -0.87 -0.87 -0.92 -0.93 -0.84 -0.85 -0.82 -0.82 0.85 -0.87 0.85 0.80 0.79 0.92 0.84 0.87 0.87 -0.78 0.87 -0.86 0.87 0.89 0.87 -0.89 -0.94 -0.96 -0.89 -0.97 -0.91 -0.93 0.89 -0.93 -0.82 -0.95 -0.98 -1.00 0.92 0.98 -0.82 -0.81 -0.92 -0.86 -0.82 -0.90 -0.83 -0.79 0.82 0.82 -0.80 -0.81 -0.80 0.81 0.79 -0.79 25 80 94 72 102 2 109 128 97 125 101 120 106 122 111 121 98 112 108 116 92 96 115 100 123 110 114 113 119 107 52 117 103 104 105 118 124 99 47 31 13 70 0.19 -0.85 -0.87 -0.92 0.29 0.26 -1.00 0.47 -0.93 -0.92 0.45 0.42 0.59 0.32 0.29 0.49 0.60 0.51 0.54 0.44 0.46 0.46 0.51 0.33 0.57 0.73 0.56 0.72 0.59 -0.98 0.46 0.56 0.62 0.50 0.46 0.33 0.43 0.36 0.25 -0.91 0.23 -0.84 11 27 36 46 51 52 64 65 66 68 69 71 72 73 74 76 77 78 80 1 GO:0002376 immune system process BP 2.66e-06 6.05 6.51 24 353 2 GO:0006955 immune response BP 9.73e-06 6.74 4.24 19 230 3 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II BP 2.48e-04 72.97 0.17 5 9 4 GO:0002684 positive regulation of immune system process BP 3.02e-04 9.47 1.59 11 86 5 GO:0051251 positive regulation of lymphocyte activation BP 1.99e-03 12.25 0.89 8 48 6 GO:0019882 antigen processing and presentation BP 2.07e-03 22.24 0.41 6 22 7 GO:0001775 cell activation BP 2.33e-03 6.23 2.78 13 151 8 GO:0002696 positive regulation of leukocyte activation BP 3.21e-03 11.39 0.94 8 51 9 GO:0050867 positive regulation of cell activation BP 4.34e-03 10.87 0.98 8 53 10 GO:0050870 positive regulation of T cell activation BP 5.59e-03 13.17 0.72 7 39 11 GO:0045321 leukocyte activation BP 6.02e-03 6.13 2.56 12 139 12 GO:0032946 positive regulation of mononuclear cell proliferation BP 7.62e-03 16.91 0.50 6 27 13 GO:0050671 positive regulation of lymphocyte proliferation BP 7.62e-03 16.91 0.50 6 27 14 GO:0070665 positive regulation of leukocyte proliferation BP 7.62e-03 16.91 0.50 6 27 15 GO:0046649 lymphocyte activation BP 0.01 6.26 2.27 11 123 16 GO:0051249 regulation of lymphocyte activation BP 0.01 9.21 1.12 8 61 17 GO:0002682 regulation of immune system process BP 0.02 5.93 2.38 11 129 18 GO:0002694 regulation of leukocyte activation BP 0.02 8.71 1.18 8 64 19 GO:0050778 positive regulation of immune response BP 0.02 10.50 0.87 7 47 20 GO:0050865 regulation of cell activation BP 0.02 8.40 1.22 8 66 21 GO:0042110 T cell activation BP 0.03 6.94 1.64 9 89 22 GO:0023052 signaling BP 0.03 3.11 16.23 31 880 23 GO:0050863 regulation of T cell activation BP 0.04 9.54 0.94 7 51 24 GO:0032944 regulation of mononuclear cell proliferation BP 0.04 12.22 0.65 6 35 25 GO:0050670 regulation of lymphocyte proliferation BP 0.04 12.22 0.65 6 35 26 GO:0070663 regulation of leukocyte proliferation BP 0.04 12.22 0.65 6 35 27 GO:0044459 plasma membrane part CC 1.50e-08 6.85 6.71 26 381 28 GO:0005886 plasma membrane CC 1.47e-07 5.55 11.40 32 647 29 GO:0044425 membrane part CC 2.14e-04 3.76 15.98 33 907 30 GO:0042613 MHC class II protein complex CC 4.36e-04 80.10 0.12 4 7 31 GO:0042611 MHC protein complex CC 5.52e-04 30.57 0.26 5 15 32 GO:0042101 T cell receptor complex CC 8.48e-04 60.06 0.14 4 8 33 GO:0031226 intrinsic to plasma membrane CC 9.84e-04 4.88 4.12 15 234 34 GO:0005887 integral to plasma membrane CC 3.52e-03 4.55 4.02 14 228 35 GO:0016020 membrane CC 7.29e-03 3.05 21.35 36 1212 36 GO:0031224 intrinsic to membrane CC 0.02 2.92 12.44 25 706 37 GO:0009897 external side of plasma membrane CC 0.04 8.04 0.92 6 52 38 GO:0016021 integral to membrane CC 0.04 2.76 12.24 24 695 39 GO:0004888 transmembrane receptor activity MF 6.24e-06 9.39 1.96 13 115 40 GO:0004871 signal transducer activity MF 5.49e-05 5.13 5.84 20 342 41 GO:0060089 molecular transducer activity MF 5.49e-05 5.13 5.84 20 342 42 GO:0004872 receptor activity MF 4.57e-04 5.76 3.30 14 193 43 GO:0004713 protein tyrosine kinase activity MF 0.05 8.15 0.91 6 53 1 05320 Autoimmune thyroid disease 1.76e-04 35.46 0.28 5 12 2 05330 Allograft rejection 2.76e-04 31.00 0.30 5 13 3 05332 Graft-versus-host disease 6.11e-04 24.77 0.35 5 15 4 04940 Type I diabetes mellitus 8.56e-04 22.50 0.37 5 16 5 05310 Asthma 2.15e-03 31.98 0.23 4 10 6 05340 Primary immunodeficiency 3.52e-03 15.41 0.48 5 21 7 04514 Cell adhesion molecules (CAMs) 3.68e-03 10.87 0.78 6 34 8 04612 Antigen processing and presentation 3.68e-03 10.87 0.78 6 34 9 04672 Intestinal immune network for IgA production 8.82e-03 19.13 0.32 4 14 10 05416 Viral myocarditis 0.02 9.80 0.69 5 30 54 module 54 7 0 2.5 1 1 32.93 27.64 958 144 200 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 305 336 337 306 307 308 309 310 311 312 313 314 340 299 300 334 335 301 302 303 304 293 294 295 296 297 298 869 269 937 704 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 0.54 0.67 0.67 0.63 0.69 0.68 0.66 0.75 0.65 0.64 0.68 0.64 0.74 0.71 0.79 0.63 0.82 0.70 0.65 0.64 0.79 0.60 0.82 0.90 1.00 0.85 0.90 0.78 0.87 0.97 0.96 0.80 0.90 0.94 0.74 0.59 0.61 0.61 0.71 0.74 0.63 0.67 0.76 0.52 0.61 0.52 0.61 0.65 0.64 0.60 0.65 0.58 0.55 0.58 -0.75 0.56 -0.71 0.58 0.56 0.56 -0.73 0.62 0.65 0.57 -0.76 -0.72 0.58 0.65 0.67 0.57 0.58 0.58 -0.73 0.63 0.53 0.64 73 81 83 89 21 4 100 66 61 62 78 76 122 16 22 90 74 75 84 115 92 107 82 80 3 117 79 99 52 103 25 43 45 44 39 91 110 86 0.08 -0.54 0.29 0.09 -0.63 -0.70 0.15 -0.63 0.27 0.65 0.16 0.34 0.32 1.00 -0.62 0.12 -0.64 -0.58 0.20 0.11 0.16 -0.67 0.18 -0.70 -0.73 -0.58 -0.58 -0.64 0.22 -0.72 -0.57 0.08 0.17 0.07 -0.63 0.13 -0.56 0.10 5 10 17 19 23 26 29 31 32 33 38 42 44 47 48 49 55 56 58 60 61 62 81 82 1 GO:0006952 defense response BP 4.53e-05 6.35 3.72 17 171 2 GO:0006935 chemotaxis BP 1.50e-04 13.64 0.93 9 43 3 GO:0042330 taxis BP 1.50e-04 13.64 0.93 9 43 4 GO:0009611 response to wounding BP 1.53e-03 5.70 3.22 14 148 5 GO:0007626 locomotory behavior BP 1.88e-03 9.62 1.24 9 57 6 GO:0009605 response to external stimulus BP 2.15e-03 4.66 4.85 17 223 7 GO:0006950 response to stress BP 0.05 2.99 10.89 24 501 8 GO:0006968 cellular defense response BP 0.05 15.14 0.46 5 21 9 GO:0005576 extracellular region CC 9.34e-09 7.67 4.48 22 222 10 GO:0044421 extracellular region part CC 6.52e-06 7.96 2.42 14 120 11 GO:0005615 extracellular space CC 3.11e-04 7.23 1.98 11 98 12 GO:0031093 platelet alpha granule lumen CC 1.23e-03 23.89 0.32 5 16 13 GO:0031983 vesicle lumen CC 1.23e-03 23.89 0.32 5 16 14 GO:0060205 cytoplasmic membrane-bounded vesicle lumen CC 1.23e-03 23.89 0.32 5 16 15 GO:0031091 platelet alpha granule CC 3.04e-03 18.75 0.38 5 19 16 GO:0005578 proteinaceous extracellular matrix CC 0.01 13.10 0.50 5 25 17 GO:0031012 extracellular matrix CC 0.04 10.06 0.63 5 31 18 GO:0008236 serine-type peptidase activity MF 6.92e-04 19.05 0.46 6 23 19 GO:0017171 serine hydrolase activity MF 6.92e-04 19.05 0.46 6 23 20 GO:0004252 serine-type endopeptidase activity MF 5.90e-03 17.69 0.40 5 20 21 GO:0005509 calcium ion binding MF 0.01 4.95 2.76 11 138 22 GO:0030246 carbohydrate binding MF 0.01 6.89 1.44 8 72 23 GO:0004857 enzyme inhibitor activity MF 0.05 6.43 1.32 7 66 55 module 55 7 0 2 2 1 33.67 32.71 908 197 200 958 1079 429 1123 994 996 147 788 193 194 195 864 807 161 162 171 173 642 988 989 148 149 150 151 152 153 439 202 199 977 1092 168 169 198 251 1088 170 139 142 143 138 140 141 134 112 155 156 1106 135 136 137 1033 203 416 75 129 68 128 992 74 172 132 133 1077 117 118 119 127 964 130 131 154 126 428 125 160 878 3 124 116 962 123 884 196 1034 94 95 96 97 98 99 91 1129 678 1085 120 121 122 167 165 83 84 1023 1022 641 959 1048 54 201 1091 146 1076 1078 1093 468 166 157 144 145 55 870 158 159 163 164 213 205 204 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 -0.45 -0.48 -0.53 -0.46 0.65 0.71 -0.46 -0.49 -0.53 -0.53 -0.47 -0.52 -0.51 -0.49 -0.52 -0.54 -0.49 -0.44 -0.56 0.75 0.79 0.77 0.77 -0.56 -0.57 -0.54 0.74 0.72 0.71 0.81 -0.72 0.75 -0.61 0.84 -0.58 0.72 0.79 0.84 0.77 0.83 -0.68 -0.80 1.00 -0.82 -0.74 -0.62 -0.57 -0.71 -0.93 -0.77 -0.73 -0.67 -0.68 -0.68 -0.80 -0.97 -0.81 -0.86 -0.82 -0.82 -0.80 -0.75 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130 131 113 678 1129 91 99 890 92 97 98 72 93 1034 112 76 172 100 101 102 103 104 105 106 107 108 109 110 111 94 95 96 123 128 74 129 992 75 117 132 118 133 119 416 203 68 428 1077 201 127 964 962 124 165 160 878 154 120 121 122 1076 1078 73 1037 1065 1066 1067 115 1105 985 126 708 725 709 937 717 886 134 934 166 963 38 979 266 47 2 1085 15 1100 116 877 114 647 648 649 650 -0.74 -0.70 -0.64 -0.78 -0.60 -0.65 -0.72 -0.62 -0.59 -0.58 -0.62 -0.72 -0.57 -0.58 0.91 0.96 -0.59 -0.64 -0.60 -0.62 -0.60 -0.62 -0.58 -0.57 -0.59 0.94 -0.72 -0.60 -0.62 -0.64 -0.68 -0.61 -0.70 -0.65 -0.63 -0.85 -0.61 -0.74 -0.59 -0.69 -0.87 -0.84 -0.67 -0.74 -0.65 -0.69 -0.70 -0.66 -0.73 -0.77 -0.94 -0.75 -0.74 -0.66 -0.74 -0.73 -0.70 -0.67 -0.59 -0.65 -1.00 -0.78 -0.79 -0.81 -0.97 -0.71 -0.70 -0.70 -0.64 -0.64 -0.76 -0.72 -0.63 -0.83 -0.80 -0.67 -0.92 -0.84 -0.84 -0.78 -0.83 -0.89 -0.77 -0.70 -0.72 -0.81 -0.88 -0.84 -0.79 -0.91 -0.77 -0.81 -0.80 -0.83 -0.91 -0.83 -0.81 -0.76 -0.78 -0.81 -0.81 -0.78 -0.71 -0.76 -0.78 -0.69 -0.66 -0.70 -0.70 -0.71 -0.61 -0.57 -0.64 -0.62 -0.64 -0.66 -0.60 -0.72 -0.73 -0.57 -0.62 -0.75 -0.66 -0.60 -0.62 -0.57 -0.64 -0.57 -0.67 -0.66 -0.67 -0.81 -0.65 -0.61 -0.65 -0.74 -0.67 -0.60 -0.72 -0.71 -0.63 -0.78 -0.66 -0.78 -0.59 -0.62 -0.61 -0.58 -0.57 -0.59 -0.61 -0.60 -0.59 -0.84 -0.74 -0.63 -0.60 -0.77 -0.57 -0.70 -0.61 -0.60 -0.66 0.92 43 45 44 42 40 41 35 36 37 -0.86 -0.87 -1.00 -0.99 -0.93 -0.98 -0.79 -0.77 -0.71 13 14 15 24 26 28 30 38 39 40 41 42 43 45 47 48 49 54 55 57 58 59 60 61 62 63 69 70 74 76 78 81 82 1 05221 Acute myeloid leukemia 0.01 6.78 1.64 8 33 2 04722 Neurotrophin signaling pathway 0.03 4.35 3.28 11 66 3 04370 VEGF signaling pathway 0.05 6.35 1.49 7 30 57 module 57 7 0 2 2 1 44.55 32.71 11 12 974 399 400 401 402 403 404 405 1040 1105 718 725 709 126 258 717 985 115 708 700 896 15 1078 1076 1065 1066 1067 1068 1069 1070 1100 2 651 652 653 654 655 656 657 469 436 437 470 1046 438 196 435 906 434 866 243 69 70 71 885 1103 894 1061 1037 53 52 430 871 905 67 877 980 984 396 73 887 114 1102 130 131 890 961 1129 87 91 72 97 98 112 85 86 76 99 92 1034 94 95 96 93 100 101 102 103 104 105 106 107 108 109 110 111 123 88 89 90 113 116 125 3 888 1032 167 884 120 121 122 128 74 75 117 132 118 133 119 416 203 68 1077 428 129 992 172 964 201 127 962 878 678 124 160 1085 165 154 891 939 1022 1023 972 83 84 667 668 983 1108 661 662 663 664 1060 418 419 420 421 422 423 0.63 0.64 0.63 0.70 -0.91 -0.93 0.63 0.65 0.61 0.60 0.70 0.66 0.69 0.68 0.72 0.65 0.68 0.84 0.64 0.80 0.67 0.63 0.60 0.68 0.65 0.70 0.63 0.66 0.69 0.70 0.69 0.68 0.66 0.77 0.60 0.69 -0.96 0.76 0.68 0.75 0.70 0.74 0.74 0.70 0.79 0.90 0.82 0.71 0.70 0.72 0.73 0.75 1.00 0.73 0.66 0.74 0.68 0.74 0.85 0.78 0.86 0.88 0.76 0.81 0.74 0.68 0.73 0.63 0.62 0.63 0.71 0.75 0.79 0.75 0.78 0.73 0.76 0.72 0.64 0.74 0.81 0.90 0.81 0.91 0.94 0.83 0.72 0.75 0.75 0.86 1.00 0.88 0.78 0.81 0.85 0.84 0.90 0.89 0.91 0.80 0.97 0.86 0.82 0.85 0.89 0.96 0.88 0.85 0.88 0.86 0.88 0.93 0.84 0.88 0.83 0.89 0.99 0.75 0.69 0.81 0.64 0.68 0.80 0.79 0.78 0.74 0.71 0.73 0.69 0.70 0.63 0.63 0.66 0.64 0.67 0.61 0.74 0.80 0.75 0.79 0.60 0.73 0.67 0.62 0.77 0.69 0.68 0.84 0.79 0.68 0.75 0.70 0.63 0.62 0.61 0.62 0.60 0.63 0.66 0.63 0.61 0.74 0.62 0.61 0.60 0.62 0.64 0.66 0.60 -0.92 0.66 0.63 108 36 45 44 42 43 40 41 35 39 0.77 0.74 0.87 0.96 1.00 0.86 0.92 0.95 0.81 0.73 2 13 24 28 30 38 39 40 41 42 43 45 47 48 49 55 56 58 59 60 61 62 63 69 70 74 76 78 81 82 1 05221 Acute myeloid leukemia 2.76e-03 7.56 1.73 9 33 2 04722 Neurotrophin signaling pathway 9.53e-03 4.59 3.46 12 66 3 04370 VEGF signaling pathway 9.53e-03 7.23 1.57 8 30 4 05223 Non-small cell lung cancer 0.01 8.10 1.26 7 24 5 05213 Endometrial cancer 0.03 7.24 1.36 7 26 6 05220 Chronic myeloid leukemia 0.04 4.86 2.41 9 46 7 05218 Melanoma 0.05 7.77 1.10 6 21 58 module 58 14 0 2 2 1 37.46 32.71 1070 1061 1079 198 266 885 907 704 1128 708 725 983 985 1105 870 991 1123 339 979 2 38 438 896 871 469 1065 1076 1066 1067 1032 1037 154 894 877 160 888 890 891 76 113 123 88 89 90 93 97 98 99 91 72 100 101 102 103 104 105 106 107 108 109 110 111 94 95 96 112 1034 172 196 115 1102 396 120 121 122 124 165 73 878 67 3 114 92 884 939 167 678 1085 962 130 131 117 118 119 132 133 416 74 129 128 75 68 155 156 1077 140 141 136 137 134 139 142 143 157 203 166 144 135 145 1033 428 138 992 1106 641 127 201 964 1022 125 1023 468 959 116 1129 126 1078 977 1093 199 170 200 161 162 244 245 246 247 248 249 250 0.56 0.59 -0.84 -0.84 0.54 0.57 0.56 0.57 0.67 0.62 0.68 0.65 0.59 0.60 0.56 0.74 0.56 0.59 0.74 0.71 0.59 0.56 0.65 0.56 0.59 0.63 0.83 0.61 0.62 0.67 0.57 0.62 0.61 0.61 0.64 0.97 0.57 0.64 0.67 0.64 0.78 0.60 0.66 0.57 0.65 0.76 0.80 0.69 0.79 0.61 0.57 0.61 0.62 0.60 0.80 0.63 0.61 0.62 0.56 0.73 0.64 0.62 0.68 0.69 0.69 0.86 0.83 0.84 0.68 0.69 0.56 0.56 0.64 0.65 0.58 0.61 0.78 0.59 0.56 0.59 0.87 0.60 0.56 0.60 0.56 0.68 0.68 0.81 0.63 0.71 0.68 0.80 0.69 0.70 0.81 0.76 0.81 0.82 0.90 0.96 0.98 0.96 0.76 0.75 0.80 0.70 0.56 0.58 0.65 0.66 0.77 0.73 -0.87 0.77 1.00 0.79 0.74 0.70 0.78 0.76 0.83 0.89 0.88 0.75 0.59 0.80 0.66 0.74 0.61 0.77 0.70 0.55 0.55 0.70 0.58 0.70 0.62 0.59 0.61 -0.87 -0.88 0.75 0.55 0.55 0.56 0.64 0.56 0.55 0.62 -0.84 0.56 102 103 25 45 43 44 42 40 41 35 -1.00 -0.94 -0.97 0.50 0.45 0.63 0.60 0.55 0.61 0.49 4 13 19 24 26 28 29 30 33 38 39 40 41 42 43 45 47 48 49 52 54 55 56 57 59 60 61 62 63 69 70 71 74 76 78 81 82 59 module 59 8 0 2 1.5 1 52.39 34.57 661 662 663 664 700 469 651 652 653 654 655 656 657 1040 709 717 115 52 434 905 887 73 160 114 890 67 888 877 396 88 89 90 878 1129 128 74 130 131 1085 992 165 884 127 120 121 122 124 116 125 167 3 196 113 97 98 112 91 72 99 92 100 101 102 103 104 105 106 107 108 109 110 111 94 95 96 1034 172 964 75 117 132 118 133 119 157 1106 135 1033 416 962 961 641 906 678 972 54 438 83 84 85 86 77 78 79 80 81 667 668 1052 866 435 1022 891 82 11 12 243 69 70 71 1100 45 46 436 437 87 894 470 963 871 76 1049 939 123 1103 974 430 885 1032 934 53 1037 1023 1046 1068 1069 1070 2 980 984 1061 129 1102 1108 1105 93 32 33 34 35 36 37 0.63 0.59 0.58 0.58 0.59 0.59 0.59 0.64 -0.83 0.58 0.60 0.66 0.63 0.63 0.63 0.71 0.75 0.68 0.76 0.70 0.81 0.73 0.67 0.78 0.81 0.63 0.71 0.70 0.72 0.74 0.77 0.77 0.68 0.80 0.59 0.69 0.75 0.76 0.72 0.73 0.67 0.78 0.64 0.58 0.62 0.66 0.70 0.77 0.69 0.64 0.67 0.77 0.82 0.89 0.89 0.87 0.83 0.82 0.87 1.00 0.87 0.85 0.86 0.87 0.83 0.84 0.85 0.85 0.90 0.92 0.76 0.83 0.79 0.82 0.92 0.84 0.80 0.74 0.62 0.62 0.69 0.72 0.67 0.61 0.57 0.58 0.58 0.56 0.60 0.65 0.77 0.57 0.64 0.79 0.62 0.64 0.82 0.60 0.67 0.76 0.77 0.58 0.58 0.63 0.65 0.60 0.63 0.63 0.70 0.79 0.61 0.65 0.75 0.71 0.70 0.67 0.85 0.68 0.66 0.69 0.67 0.60 0.58 0.60 0.61 0.80 0.75 0.66 0.59 0.66 0.83 0.64 0.73 0.75 0.75 0.59 0.77 0.62 0.68 0.64 0.73 0.81 0.58 0.72 0.61 0.59 0.58 0.61 0.59 0.63 0.67 0.69 0.81 0.61 0.57 0.80 0.56 0.57 0.56 -0.84 0.57 0.63 33 91 39 108 43 45 44 42 40 41 35 36 37 38 34 126 116 27 0.63 0.65 0.82 0.82 0.88 0.87 0.95 0.98 0.96 1.00 0.89 0.88 0.78 0.80 0.70 0.67 0.77 0.66 13 24 28 30 38 39 40 41 42 43 45 47 48 49 52 55 56 57 58 60 61 62 63 69 70 76 81 82 1 04370 VEGF signaling pathway 9.97e-05 10.44 1.55 10 30 2 04722 Neurotrophin signaling pathway 1.53e-03 5.24 3.42 13 66 3 05221 Acute myeloid leukemia 2.31e-03 7.68 1.71 9 33 4 05223 Non-small cell lung cancer 0.01 8.23 1.24 7 24 5 05211 Renal cell carcinoma 0.01 6.73 1.66 8 32 6 05210 Colorectal cancer 0.01 5.73 2.12 9 41 7 05200 Pathways in cancer 0.02 3.36 6.16 16 119 8 04664 Fc epsilon RI signaling pathway 0.02 6.20 1.76 8 34 9 05213 Endometrial cancer 0.02 7.35 1.35 7 26 10 05220 Chronic myeloid leukemia 0.04 4.94 2.38 9 46 11 04662 B cell receptor signaling pathway 0.04 4.80 2.43 9 47 12 05218 Melanoma 0.04 7.89 1.09 6 21 60 module 60 10 0 2 1.5 1 35.15 34.57 1120 993 865 698 699 954 955 441 730 1042 1110 975 1082 731 903 936 703 518 708 889 1045 702 1086 1080 1128 680 1122 1101 733 738 739 1121 751 765 769 770 752 750 736 737 753 745 735 746 747 796 797 798 799 777 778 779 780 781 734 701 398 725 718 259 710 408 409 410 728 726 727 719 720 721 722 723 724 712 713 714 715 716 711 983 705 706 707 937 985 258 709 717 700 896 894 93 115 126 428 135 704 681 682 683 684 685 344 686 687 688 689 690 691 692 693 694 695 696 697 0.70 -0.81 0.72 0.82 0.78 -0.81 0.71 0.73 -0.81 -0.84 -0.88 0.72 -0.89 -0.83 0.71 -0.87 -0.83 0.79 0.90 -0.90 -0.83 0.74 0.69 -0.95 0.83 0.75 0.73 0.70 0.77 -0.80 -0.85 0.69 0.74 -0.85 -0.84 -0.80 0.88 0.68 0.76 -0.90 1.00 0.72 0.86 0.78 -0.89 0.75 0.80 -0.85 -0.84 -0.92 0.76 0.67 0.86 0.86 0.75 0.88 -0.81 0.69 0.69 0.67 0.73 -0.89 -0.94 -0.94 -0.84 -0.84 -0.93 -0.83 0.68 0.72 -0.82 0.66 0.79 0.76 -0.84 0.79 0.67 -0.91 0.72 0.72 -0.80 -0.83 0.74 0.71 0.84 0.82 0.81 0.70 0.73 0.78 0.67 0.72 0.78 0.96 0.75 0.80 0.73 -0.82 -0.85 0.72 -0.84 -0.82 0.73 0.73 0.88 0.85 0.74 0.66 0.84 0.76 0.67 0.69 0.74 0.66 0.67 49 50 79 23 85 56 55 53 54 52 99 103 43 44 45 0.60 1.00 0.67 0.91 0.65 0.65 0.75 0.67 0.81 -0.69 -0.66 -0.81 0.80 0.99 0.71 29 32 38 39 40 41 42 43 45 47 48 49 54 55 56 57 58 59 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 61 module 61 13 0 2 1.5 1 45.52 34.57 200 339 38 82 197 972 1040 1105 126 725 983 115 985 896 961 430 905 1037 1065 1066 1067 1076 469 53 52 1061 894 871 67 678 878 906 980 984 887 877 888 1032 396 73 132 133 939 438 88 89 90 1102 891 114 890 91 1129 130 131 76 113 97 98 92 72 93 99 1034 112 100 101 102 103 104 105 106 107 108 109 110 111 94 95 96 123 116 125 129 3 120 121 122 160 1085 124 117 118 119 127 964 172 75 992 1106 74 135 1033 128 416 203 68 155 156 134 140 141 136 137 641 157 154 1077 167 1022 142 143 144 428 138 201 977 1093 1023 959 884 166 145 196 1078 139 468 870 165 54 1048 55 83 84 994 807 1091 1100 979 2 962 991 1123 85 86 87 146 0.61 0.69 0.59 0.62 0.60 0.63 0.62 0.63 0.68 0.59 0.60 0.79 0.61 0.58 0.68 0.58 0.67 0.66 0.57 0.59 0.59 0.79 0.68 0.59 0.65 0.60 0.66 0.66 0.60 0.80 0.68 0.57 0.64 0.65 0.70 0.69 0.87 0.70 0.67 0.68 0.89 0.85 0.69 0.71 0.74 0.76 0.65 0.66 0.76 0.73 0.76 0.89 0.74 0.86 0.81 0.82 0.76 0.89 0.91 0.70 0.75 0.71 0.79 0.93 0.98 0.72 0.69 0.76 0.79 0.83 0.77 0.76 0.72 0.71 0.78 0.71 0.72 0.76 0.82 0.89 0.81 0.80 0.84 1.00 0.76 0.69 0.68 0.71 0.67 0.83 0.75 0.83 0.80 0.74 0.82 0.85 0.96 0.97 0.94 0.83 0.92 0.79 0.85 0.91 0.88 0.98 0.93 0.82 0.79 0.69 0.74 0.69 0.69 0.77 0.72 0.81 0.69 0.77 0.75 0.72 0.78 -0.87 0.73 0.80 0.89 0.76 0.64 0.60 0.70 0.59 0.79 0.74 0.75 0.84 0.67 0.72 0.63 0.56 0.80 0.72 0.63 0.59 0.59 0.61 0.57 0.57 0.58 0.57 0.66 0.71 0.75 0.59 0.58 0.62 0.65 0.58 0.60 126 37 39 45 43 44 42 40 41 35 36 38 34 116 108 25 102 103 97 0.34 0.40 0.39 0.50 0.48 0.61 0.60 0.56 0.67 0.55 0.45 0.39 0.32 0.40 0.36 -0.97 -1.00 -0.89 -0.87 4 13 19 24 26 28 29 30 33 38 39 40 41 42 43 45 47 48 49 52 54 55 56 57 58 59 60 62 63 67 69 70 74 76 78 81 82 1 05221 Acute myeloid leukemia 0.02 6.35 1.73 8 33 62 module 62 9 0 2 1.5 1 45.18 34.57 1093 171 864 807 56 166 145 144 158 159 977 994 996 142 143 199 886 1078 1076 339 891 1023 139 123 971 972 138 468 116 55 870 1048 939 160 959 641 201 878 1129 77 78 79 80 81 82 1052 667 668 1022 83 84 866 890 887 888 877 435 1032 67 88 89 90 980 984 87 74 93 884 961 97 98 85 86 91 72 94 95 96 100 101 102 103 104 105 106 107 108 109 110 111 92 114 130 131 196 1034 678 120 121 122 125 1085 112 992 962 165 129 124 127 132 133 1106 172 1033 140 141 117 118 119 128 68 155 156 416 75 203 1077 157 428 134 438 73 154 167 136 137 905 113 396 146 906 135 115 126 964 3 1091 54 1102 1114 99 76 670 671 672 673 674 675 676 677 -0.58 -0.65 -0.60 -0.61 -0.59 -0.74 -0.70 -0.70 -0.68 -0.65 -0.69 -0.58 -0.62 -0.76 0.88 0.82 -0.63 -0.64 -0.67 -0.64 -0.74 -0.71 -0.70 -0.75 0.83 -0.61 -0.84 -0.69 -0.76 -0.63 -0.62 -0.73 -0.69 -0.70 -0.66 -0.74 -0.78 -0.78 -0.81 -0.60 -0.64 -0.62 -0.59 -0.60 -0.71 -0.58 -0.59 -0.61 -0.79 -0.69 -0.71 -0.57 -0.76 -0.66 -0.63 -0.68 -0.61 -0.69 -0.57 -0.67 -0.67 -0.64 -0.59 -0.68 -0.62 -0.91 -0.59 -0.73 -0.74 -0.88 -0.83 -0.60 -0.66 -0.83 -0.77 -0.77 -0.83 -0.87 -0.67 -0.67 -0.79 -0.77 -0.71 -0.78 -0.77 -0.68 -0.68 -0.71 -0.73 -0.76 -0.66 -0.72 -0.89 -0.84 -0.85 -0.85 -0.83 -0.72 -0.63 -0.72 -0.75 -0.81 -0.96 -0.93 -0.78 -0.79 -0.96 -0.83 -0.73 -0.89 -0.88 -0.88 -1.00 -0.85 -0.81 -0.74 -0.83 -0.86 -0.84 -0.88 -0.87 -0.85 -0.80 -0.91 -0.92 -0.96 -0.68 -0.80 -0.75 -0.69 -0.65 -0.72 -0.73 -0.81 -0.76 -0.78 -0.65 -0.74 -0.66 -0.70 -0.60 -0.76 -0.71 -0.67 -0.84 -0.73 -0.66 -0.80 -0.66 -0.62 -0.79 -0.74 -0.59 -0.59 -0.60 -0.57 -0.59 -0.62 -0.59 -0.59 27 30 91 108 116 126 34 38 39 37 36 35 41 40 42 44 43 45 25 57 97 102 -0.20 -0.18 -0.23 -0.28 -0.32 -0.26 -0.29 -0.35 -0.31 -0.32 -0.36 -0.48 -0.52 -0.42 -0.45 -0.44 -0.38 -0.35 0.92 0.84 0.86 1.00 4 13 19 24 26 28 29 30 33 38 39 40 41 42 43 45 47 48 49 52 54 55 56 57 58 59 60 61 63 67 69 70 76 81 82 1 05221 Acute myeloid leukemia 3.11e-03 7.44 1.75 9 33 2 04370 VEGF signaling pathway 0.01 7.12 1.59 8 30 3 04662 B cell receptor signaling pathway 0.01 5.39 2.50 10 47 4 05223 Non-small cell lung cancer 0.02 7.98 1.28 7 24 5 04664 Fc epsilon RI signaling pathway 0.03 6.01 1.81 8 34 6 05213 Endometrial cancer 0.03 7.13 1.38 7 26 7 05220 Chronic myeloid leukemia 0.05 4.78 2.44 9 46 63 module 63 10 0 2 1.5 1 48.68 34.57 1114 77 78 79 80 81 667 668 120 121 122 980 984 1102 1129 1085 92 88 89 90 99 91 97 98 112 72 93 1034 100 101 102 103 104 105 106 107 108 109 110 111 94 95 96 76 172 130 131 992 117 118 119 129 132 133 74 128 135 1106 155 156 68 136 137 157 140 141 75 1033 203 416 160 124 1022 1023 678 428 641 1077 964 878 165 167 154 54 146 67 435 396 82 887 11 12 430 871 891 877 888 866 885 1103 939 1052 894 961 126 52 906 434 3 114 1111 886 243 69 70 71 468 717 115 55 73 139 438 113 125 469 884 1049 905 53 890 116 959 971 870 972 123 196 991 87 1037 1078 1046 1048 339 962 1066 1067 1068 1069 1070 1061 1076 2 138 1032 1100 83 84 1108 201 1091 127 85 86 134 0.64 0.64 0.64 0.66 0.67 0.66 0.64 0.67 0.70 0.70 0.74 0.66 0.68 0.81 0.90 0.84 0.94 0.74 0.80 0.81 0.90 0.91 0.97 0.96 1.00 0.87 0.81 0.91 0.89 0.85 0.89 0.91 0.87 0.87 0.89 0.87 0.91 0.92 0.80 0.86 0.84 0.90 0.99 0.91 0.95 0.87 0.87 0.88 0.78 0.81 0.77 0.89 0.81 0.80 0.84 0.77 0.67 0.75 0.64 0.63 0.74 0.67 0.65 0.73 0.68 0.61 0.80 0.72 0.75 0.77 0.74 0.79 0.75 0.70 0.87 0.70 0.67 0.69 0.85 0.78 0.81 0.77 0.66 0.76 0.63 0.69 0.67 0.77 0.73 0.84 0.73 0.63 0.76 0.70 0.80 0.79 0.84 0.74 0.65 0.72 0.78 0.75 0.75 0.83 0.65 0.63 0.67 0.73 0.75 0.79 0.62 0.62 0.80 0.66 0.66 0.66 0.64 0.65 0.80 0.63 0.79 0.62 0.85 0.85 0.79 0.64 0.86 0.68 0.76 0.75 0.87 0.82 0.63 -0.92 0.68 0.65 0.82 0.89 0.62 0.79 0.80 0.63 0.69 0.63 0.67 0.74 0.63 0.62 0.65 0.64 0.63 0.73 0.69 0.69 0.67 0.74 0.68 0.68 0.73 0.66 0.69 0.63 0.76 0.78 0.82 0.66 27 91 108 116 126 34 38 37 39 36 35 41 40 42 44 43 45 25 102 0.51 0.49 0.63 0.62 0.54 0.56 0.66 0.64 0.67 0.75 0.80 0.89 0.81 0.85 0.84 0.72 0.72 -0.99 -1.00 13 19 24 26 28 29 30 38 39 40 41 42 43 45 47 48 49 52 55 56 57 58 59 60 61 62 67 69 70 76 81 82 1 05221 Acute myeloid leukemia 5.37e-03 6.90 1.87 9 33 2 04370 VEGF signaling pathway 0.02 6.61 1.70 8 30 3 04662 B cell receptor signaling pathway 0.02 4.99 2.66 10 47 4 05223 Non-small cell lung cancer 0.02 7.41 1.36 7 24 5 05213 Endometrial cancer 0.04 6.62 1.47 7 26 64 module 64 12 0 2 1.5 1 42.27 34.57 978 936 518 551 552 553 554 555 556 557 558 669 1027 442 519 520 521 522 523 524 525 526 527 528 529 530 990 560 561 562 563 564 565 995 39 42 43 41 40 1038 1113 567 568 569 570 571 572 573 574 575 576 252 253 254 924 925 926 935 616 617 618 619 909 910 911 912 577 578 579 580 581 582 583 584 585 586 981 424 425 48 900 901 465 242 406 902 559 1029 1026 417 745 746 747 769 770 464 904 566 982 1035 703 1081 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 879 1028 475 531 532 533 534 535 536 537 538 539 540 541 542 543 544 545 546 547 548 549 550 0.66 -0.66 0.67 -0.65 0.68 0.72 0.69 0.68 0.67 0.69 -0.71 0.72 -0.72 0.71 -0.77 -0.84 0.72 0.72 0.68 0.69 0.68 -0.68 -0.68 -0.77 0.80 -0.73 0.73 -0.70 -0.81 0.69 -0.90 0.77 -0.78 0.68 -0.82 -0.88 -0.81 -0.86 -0.79 0.84 0.75 -0.73 -0.69 -1.00 -0.85 -0.87 -0.72 -0.85 0.72 -0.77 0.71 0.67 0.81 0.85 0.89 0.92 0.95 0.83 0.68 0.88 -0.65 0.72 0.77 0.86 0.79 0.85 0.69 0.70 0.77 0.77 -0.83 0.66 -0.69 0.66 0.67 0.66 -0.66 0.66 0.69 -0.69 0.69 0.74 -0.67 -0.66 -0.76 0.75 0.79 -0.68 0.75 -0.68 0.66 0.80 -0.66 -0.66 -0.67 0.77 -0.71 0.66 0.71 -0.67 -0.77 0.72 -0.66 -0.68 -0.70 -0.75 -0.79 -0.69 -0.79 -0.85 -0.82 -0.72 -0.66 -0.73 -0.68 -0.75 -0.79 -0.78 -0.68 -0.71 -0.77 -0.82 -0.78 -0.81 -0.72 -0.71 -0.83 -0.76 -0.83 -0.76 -0.97 -0.90 -0.76 -0.71 0.83 -0.77 0.73 -0.82 0.66 -0.78 0.69 -0.73 -0.65 -0.73 -0.73 -0.73 -0.72 0.67 -0.84 0.68 0.67 0.80 0.66 54 99 103 117 52 107 119 113 114 110 96 112 108 98 111 121 115 109 0.94 -0.25 -0.40 -0.50 -0.41 1.00 -0.53 -0.66 -0.40 -0.72 -0.50 -0.45 -0.49 -0.51 -0.28 -0.42 -0.34 0.91 6 11 27 32 34 35 36 46 50 51 52 53 60 65 66 68 69 71 72 73 74 75 76 77 78 79 80 81 82 1 GO:0022403 cell cycle phase BP 1.49e-03 3.97 7.02 22 159 2 GO:0006260 DNA replication BP 5.28e-03 5.03 3.79 15 86 3 GO:0007051 spindle organization BP 5.40e-03 12.22 1.01 8 23 4 GO:0022402 cell cycle process BP 5.64e-03 3.24 10.02 26 227 5 GO:0007346 regulation of mitotic cell cycle BP 7.54e-03 6.93 2.12 11 48 6 GO:0002376 immune system process BP 7.67e-03 2.75 15.58 34 353 7 GO:0007049 cell cycle BP 0.01 2.73 15.13 33 343 8 GO:0000279 M phase BP 0.02 4.03 5.21 17 118 9 GO:0048015 phosphoinositide-mediated signaling BP 0.02 9.64 1.19 8 27 10 GO:0019932 second-messenger-mediated signaling BP 0.02 5.50 2.78 12 63 11 GO:0000278 mitotic cell cycle BP 0.03 3.24 8.30 22 188 12 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II BP 0.03 28.09 0.40 5 9 13 GO:0000226 microtubule cytoskeleton organization BP 0.03 5.81 2.43 11 55 14 GO:0007017 microtubule-based process BP 0.04 4.77 3.40 13 77 15 GO:0042101 T cell receptor complex CC 1.86e-03 37.36 0.35 5 8 16 GO:0044459 plasma membrane part CC 6.51e-03 2.48 16.84 34 381 17 GO:0042105 alpha-beta T cell receptor complex CC 0.02 Inf 0.13 3 3 18 GO:0042613 MHC class II protein complex CC 0.03 29.66 0.31 4 7 19 GO:0015630 microtubule cytoskeleton CC 0.05 2.96 7.16 18 162 20 GO:0004871 signal transducer activity MF 5.84e-03 2.66 14.88 32 342 21 GO:0060089 molecular transducer activity MF 5.84e-03 2.66 14.88 32 342 22 GO:0004888 transmembrane receptor activity MF 0.04 3.58 5.00 15 115 1 04110 Cell cycle 1.04e-05 6.33 4.04 17 75 2 03030 DNA replication 0.01 7.86 1.29 7 24 3 05320 Autoimmune thyroid disease 0.02 13.35 0.65 5 12 4 05330 Allograft rejection 0.03 11.68 0.70 5 13 5 05340 Primary immunodeficiency 0.05 7.54 1.13 6 21 65 module 65 7 0 2 1.5 1 38.27 34.57 957 854 855 856 857 858 859 860 956 969 938 730 805 806 1039 1043 802 803 728 1082 1084 1051 471 472 473 268 1054 57 417 466 467 1127 1122 1115 782 738 739 783 784 785 786 774 775 776 1119 761 762 763 764 970 754 756 769 770 750 740 745 735 746 747 753 777 778 779 780 781 796 797 798 799 736 737 742 748 749 751 771 772 773 757 758 759 755 1086 766 767 768 743 744 800 801 862 863 1125 1126 787 789 790 791 792 793 794 795 1041 1035 883 788 765 1121 760 752 1036 1025 880 733 732 407 397 559 1101 734 731 944 1026 741 872 873 874 -0.76 0.81 -0.77 0.77 -0.75 -0.74 0.80 0.78 -0.78 0.78 0.79 -0.75 0.82 0.79 -0.77 -0.75 -0.77 -0.74 -0.74 -0.80 -0.74 0.79 -0.83 0.78 -0.74 -0.75 -0.74 -0.81 -0.88 0.85 0.77 0.85 0.90 0.82 -0.79 -0.86 -0.80 -0.75 -0.87 -0.92 0.97 0.82 0.84 0.81 0.80 -0.84 -0.82 0.79 0.89 -0.91 -0.79 0.81 -0.80 -0.76 0.87 -0.89 0.83 0.90 0.79 -0.77 0.87 -0.84 0.83 0.90 0.88 0.94 0.93 0.84 -0.94 -0.92 1.00 -0.94 -0.85 -0.91 -0.95 0.82 -0.96 -0.85 -0.90 1.00 -0.90 0.93 0.83 0.87 -0.81 -0.81 0.90 0.85 0.82 -0.86 0.79 -0.82 -0.76 0.92 -0.88 0.84 -0.74 -0.80 0.80 -0.76 0.81 -0.81 0.78 -0.76 -0.80 -0.76 -0.82 -0.83 0.81 0.84 0.88 0.80 -0.75 -0.76 0.81 -0.77 -0.75 -0.89 0.78 0.84 0.84 -0.78 -0.80 0.84 0.85 -0.75 -0.78 0.79 88 50 79 53 23 85 56 55 54 46 82 60 48 57 51 47 119 107 52 0.59 0.57 0.64 0.70 0.80 0.88 0.68 0.80 1.00 0.56 0.63 0.69 0.59 0.69 0.60 -0.74 -0.78 0.77 -0.81 32 46 51 53 55 60 64 66 67 68 69 71 72 73 74 75 76 77 78 79 80 81 82 66 module 66 20 0 2 1.5 1 38.08 34.57 940 476 867 44 1042 1045 1062 732 1041 1025 944 407 268 731 880 397 733 1051 1122 471 472 473 788 789 790 791 792 793 794 795 57 787 783 784 785 786 1125 1126 774 775 776 761 762 763 764 970 1086 766 767 768 765 755 757 758 759 748 749 742 736 737 796 797 798 799 753 777 778 779 780 781 745 735 746 747 750 740 754 752 771 772 773 769 770 743 744 741 738 739 751 1121 883 756 782 760 800 801 862 863 1119 1036 417 1035 1026 559 1029 1118 1116 1115 1117 804 1127 1101 1054 734 1124 466 467 679 -0.76 0.73 0.73 0.77 0.75 0.78 -0.76 0.78 0.76 0.78 0.77 0.76 0.75 0.75 0.81 0.77 -0.77 -0.82 -0.82 0.83 -0.75 0.75 0.78 0.78 0.77 -0.78 0.74 -0.76 0.78 -0.75 0.77 -0.82 0.75 0.81 0.80 -0.94 -0.87 0.86 -0.85 -0.78 -0.76 0.84 0.78 -0.80 -0.84 0.92 -0.84 0.82 0.81 -0.87 0.81 -0.82 -0.96 0.86 -0.88 0.89 0.95 0.86 -1.00 0.90 -0.84 -0.78 0.91 0.90 -0.82 0.82 -0.83 -0.88 -0.81 -0.89 -0.84 -0.86 -0.78 0.75 -0.82 0.85 0.78 -0.83 0.95 0.85 0.86 0.87 0.75 -0.85 -0.82 -0.78 0.85 0.78 -0.87 -0.80 0.84 -0.85 0.76 -0.83 0.90 -0.76 0.77 0.77 -0.81 -0.75 0.90 0.80 -0.82 -0.81 0.76 0.75 0.74 -0.79 0.74 -0.79 -0.82 -0.81 0.77 -0.83 -0.77 -0.81 -0.79 0.74 57 48 88 50 79 23 85 56 55 51 82 60 46 53 54 107 119 52 113 114 47 -0.69 -0.54 -0.55 -0.57 -0.64 -0.79 -0.88 -0.65 -0.83 -0.60 -0.63 -0.71 -0.58 -0.69 -1.00 -0.79 0.98 0.98 0.85 0.86 0.86 32 46 50 51 53 55 60 64 65 67 68 69 71 72 73 74 75 76 77 78 79 80 81 82 1 01100 Metabolic pathways 0.05 2.75 11.90 23 315 67 module 67 15 0 2 1.5 1 36.65 34.57 1087 1089 1090 881 882 861 940 804 986 805 806 854 855 856 857 858 859 860 471 472 473 732 1051 1122 466 467 1115 57 787 783 784 785 786 774 775 776 761 762 763 764 970 1086 766 767 768 757 758 759 755 765 751 771 772 773 742 796 797 798 799 736 737 748 749 743 744 1036 800 801 1125 1126 862 863 788 789 790 791 792 793 794 795 802 803 957 969 1114 1091 807 864 193 194 195 147 808 809 810 811 812 813 814 815 816 817 818 819 820 821 822 823 824 825 826 827 828 829 830 831 832 833 834 835 836 837 838 839 840 841 842 843 844 845 846 847 848 849 850 851 852 853 -0.82 0.76 -0.79 -0.82 -0.87 0.73 -0.82 -0.78 0.71 -0.81 -0.80 -0.84 0.77 -0.86 0.79 0.75 -0.87 -0.85 0.82 -0.89 0.76 0.74 -0.83 -0.83 -0.91 -0.80 -0.78 0.87 -0.94 0.81 0.85 0.81 -0.99 -0.85 -0.89 -0.82 0.85 0.76 -0.83 -0.88 0.94 -0.92 0.71 0.76 -0.94 -1.00 0.76 -0.91 -0.81 0.73 -0.82 0.82 0.76 0.79 0.79 -0.79 -0.81 0.82 0.70 -0.90 0.89 0.92 0.85 -0.78 -0.82 -0.85 0.86 -0.91 -0.98 0.80 0.74 0.73 0.86 0.79 0.82 -0.96 0.84 -0.97 0.89 -0.90 0.74 0.89 0.81 -0.81 0.79 0.74 0.84 0.79 0.83 0.72 0.74 0.77 0.74 -0.82 0.75 0.70 -0.87 0.73 0.78 0.71 0.75 -0.81 0.74 -0.80 -0.79 -0.83 -0.87 -0.84 0.76 -0.80 -0.78 0.79 -0.83 -0.78 0.75 0.78 0.79 -0.80 0.71 -0.83 -0.89 -0.80 -0.79 -0.83 -0.78 -0.82 -0.84 0.70 0.73 -0.79 -0.82 -0.78 0.71 -0.78 -0.80 -0.79 -0.79 -0.79 35 102 57 47 48 23 85 79 56 55 53 54 51 46 82 60 107 119 12 0.99 -0.73 -0.81 0.89 -0.54 -0.63 -0.88 -0.49 -0.48 -0.59 -0.50 -0.90 -0.51 -0.48 -0.51 -0.52 -0.83 0.97 1.00 38 55 60 61 62 63 65 66 68 69 70 71 73 74 75 76 78 79 80 81 82 1 GO:0000428 DNA-directed RNA polymerase complex CC 0.05 24.32 0.33 4 8 2 GO:0005665 DNA-directed RNA polymerase II, core complex CC 0.05 24.32 0.33 4 8 3 GO:0030880 RNA polymerase complex CC 0.05 24.32 0.33 4 8 4 GO:0055029 nuclear DNA-directed RNA polymerase complex CC 0.05 24.32 0.33 4 8 1 03020 RNA polymerase 7.96e-03 33.80 0.28 4 7 68 module 68 9 0 2 1.5 1 35.67 34.57 867 865 710 474 1082 1083 1081 397 805 806 51 987 1024 259 1116 464 1026 559 407 1121 756 760 782 1119 783 784 785 786 1125 1126 774 775 776 761 762 763 764 970 1036 1086 766 767 768 765 755 757 758 759 742 771 772 773 748 749 752 754 740 736 737 750 735 745 796 797 798 799 777 778 779 780 781 746 747 738 739 769 770 751 753 741 417 1122 734 1127 1035 57 466 467 1101 1041 1115 787 733 1084 969 938 476 1109 1042 411 412 413 414 415 0.76 -0.75 -0.78 -0.75 0.77 0.77 -0.82 0.77 -0.83 -0.80 -0.77 0.79 -0.80 -0.79 0.79 -0.76 -0.86 -0.84 0.80 -0.82 -0.83 -0.84 0.81 -0.75 0.79 0.88 0.82 -0.90 -0.85 0.77 -0.78 -0.84 -0.77 0.77 0.83 -0.78 -0.90 0.86 -0.78 -0.87 0.81 0.84 -0.87 0.85 -0.82 -0.90 0.84 -0.90 0.81 0.86 0.83 0.87 0.77 0.90 -0.82 0.86 0.86 -0.96 0.94 -0.82 -0.99 -0.91 -0.92 -0.81 0.87 0.92 0.86 -0.86 -0.90 -0.88 -1.00 -0.82 0.84 0.89 0.84 0.88 0.79 -0.78 -0.91 -0.86 0.78 -0.84 -0.81 -0.80 0.84 0.77 -0.80 -0.76 -0.78 0.79 -0.82 -0.76 -0.82 0.78 -0.79 -0.78 0.80 0.75 0.81 -0.80 -0.81 -0.81 0.81 -0.82 88 50 79 23 85 56 55 82 60 51 46 53 54 107 52 117 103 119 -0.60 -0.64 -0.60 -0.77 -0.86 -0.71 -0.78 -0.68 -0.70 -0.59 -0.64 -0.77 -1.00 -0.69 0.75 0.69 0.70 0.73 32 46 50 51 53 60 64 65 66 67 69 71 72 73 74 75 76 77 78 79 80 81 82 69 module 69 9 0 2 1 1 45.52 37.04 1044 1043 1036 1128 982 1035 904 566 1038 464 1113 1118 883 1116 1054 804 417 1121 765 755 757 758 759 752 754 769 770 746 747 751 771 772 773 748 749 736 737 796 797 798 799 753 750 740 742 735 777 778 779 780 781 745 738 739 743 744 741 1122 1101 1127 733 701 710 398 259 708 718 725 734 408 409 410 728 726 727 719 720 721 722 723 724 126 709 24 1031 731 730 729 956 1084 960 889 732 875 876 0.86 0.86 -0.71 -0.73 -0.73 0.84 0.89 -0.72 -0.72 -0.76 -0.76 0.82 0.83 0.91 0.84 -0.74 0.91 -0.75 0.87 -0.71 -0.71 0.85 -0.74 -0.75 0.86 0.87 0.86 -0.84 0.96 -0.78 0.90 0.90 0.89 0.88 0.96 -0.87 0.88 -0.77 -0.85 0.95 0.89 -0.97 -0.75 0.90 0.90 -0.85 1.00 -0.94 -0.92 -0.90 -0.92 -0.85 0.87 0.85 -0.76 -0.75 -0.77 -0.77 -0.82 -0.82 -0.75 -0.82 -0.81 0.88 -0.75 -0.87 -0.76 -0.78 -0.79 0.86 0.86 0.86 0.87 0.87 0.84 0.85 -0.73 -0.74 0.83 -0.73 -0.74 -0.72 -0.73 0.86 0.82 0.84 0.83 -0.71 0.87 0.87 0.89 0.85 0.85 0.82 -0.71 10 3 26 33 40 42 43 44 45 25 62 49 48 88 50 46 82 60 23 85 56 55 53 54 79 57 51 47 52 119 107 113 117 103 124 104 118 99 105 110 114 123 100 2 68 0.42 0.45 0.46 -0.53 -0.56 -0.61 -0.63 -0.69 -0.56 0.47 -0.55 -0.60 -0.61 -0.69 -0.86 -0.63 -0.65 -0.72 -0.90 -0.93 -0.78 -0.84 -0.83 -1.00 -0.73 -0.68 -0.72 0.61 0.76 0.58 -0.69 0.61 0.58 0.71 0.68 0.65 0.52 0.57 0.53 0.43 0.49 0.47 0.41 0.44 -0.50 32 42 46 51 53 55 56 57 58 59 60 61 62 63 64 65 66 67 68 70 71 72 73 74 75 76 77 78 79 80 81 82 70 module 70 11 0 2 1 1 62.17 37.04 1049 77 78 79 80 81 430 243 114 1085 939 888 130 131 878 438 877 396 120 121 122 160 1102 890 891 678 884 88 89 90 93 99 97 98 92 112 72 100 101 102 103 104 105 106 107 108 109 110 111 94 95 96 1034 91 125 167 172 992 129 128 75 416 74 132 133 117 118 119 1077 68 136 137 140 141 1106 155 156 134 1033 203 962 428 157 964 127 201 135 126 154 165 146 83 84 980 984 85 86 667 668 82 69 70 71 11 12 1100 434 905 887 885 1103 871 53 52 87 115 894 3 906 436 437 196 470 866 124 116 67 934 961 959 123 972 974 977 73 435 1052 1022 1023 76 113 1037 1032 1048 1046 54 641 15 1061 1091 56 38 1105 45 46 1114 1129 58 59 60 61 62 63 64 65 66 -0.72 -0.78 -0.71 -0.76 -0.76 -0.76 -0.84 -0.73 -0.88 -0.85 -0.84 -0.74 -0.91 -0.92 -0.86 -0.81 -0.84 -0.83 -0.77 -0.69 -0.79 -0.83 -0.90 -0.91 -0.93 -0.94 -0.79 -0.83 -0.82 -0.77 -0.85 -0.93 -0.97 -0.96 -0.90 -0.98 -0.96 -0.79 -0.86 -0.94 -0.93 -0.86 -0.90 -0.93 -0.93 -0.84 -0.89 -0.90 -0.95 -0.90 -0.93 -0.98 -0.97 -0.90 -0.79 -0.76 -1.00 -0.91 -0.85 -0.77 -0.82 -0.73 -0.86 -0.85 -0.88 -0.77 -0.90 -0.79 -0.72 -0.75 -0.69 -0.70 -0.71 -0.75 -0.85 -0.68 -0.73 -0.77 -0.72 -0.72 -0.84 -0.71 -0.76 -0.88 -0.77 -0.70 -0.75 -0.73 -0.76 -0.79 -0.70 -0.71 -0.80 -0.73 -0.78 -0.87 -0.87 -0.76 -0.79 -0.85 -0.78 -0.79 -0.80 -0.72 -0.74 -0.77 -0.80 -0.84 -0.87 -0.68 -0.82 -0.71 -0.81 -0.76 -0.87 -0.89 -0.82 -0.80 -0.77 -0.76 -0.68 -0.91 -0.68 -0.75 -0.89 -0.88 -0.71 -0.77 -0.89 -0.67 -0.83 -0.71 -0.70 -0.70 -0.90 -0.79 -0.76 -0.84 -0.72 -0.89 -0.91 -0.81 -0.70 -0.74 -0.73 -0.85 -0.77 -0.69 -0.74 -0.71 -0.69 -0.69 -0.71 -0.68 -0.69 -0.70 -0.89 -0.69 -0.68 -0.69 -0.69 -0.68 -0.73 -0.72 -0.73 -0.68 98 50 24 26 93 28 30 27 126 116 108 36 45 41 42 40 44 43 35 39 37 38 34 91 33 121 31 29 32 25 103 57 97 102 0.50 -0.43 0.54 0.68 -0.53 0.60 -0.52 -0.66 -0.70 -0.77 -0.76 -0.85 -0.84 -1.00 -0.92 -0.93 -0.94 -0.86 -0.94 -0.79 -0.77 -0.81 -0.72 -0.64 -0.58 0.69 0.64 -0.54 0.66 0.72 0.56 0.56 0.58 0.72 13 19 28 29 30 38 39 40 41 42 43 45 47 48 49 52 55 56 57 58 59 60 61 62 63 67 69 76 81 82 1 GO:0005829 cytosol CC 0.03 2.13 24.18 42 517 2 GO:0030507 spectrin binding MF 0.04 Inf 0.14 3 3 1 04370 VEGF signaling pathway 1.79e-03 8.14 1.66 9 30 2 05221 Acute myeloid leukemia 4.17e-03 7.11 1.82 9 33 3 04722 Neurotrophin signaling pathway 0.02 4.30 3.65 12 66 4 05223 Non-small cell lung cancer 0.02 7.63 1.33 7 24 5 05213 Endometrial cancer 0.03 6.82 1.44 7 26 71 module 71 14 0 2 1 1 45.71 37.04 987 1127 1054 756 1086 1119 880 738 739 741 782 800 801 862 863 1125 1126 970 1036 761 762 763 764 766 767 768 765 757 758 759 769 770 755 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0.89 0.99 0.78 0.95 1.00 0.86 0.81 0.83 0.70 0.79 -0.75 -0.62 -0.66 -0.65 -0.62 -0.59 -0.48 -0.55 0.85 -0.50 -0.72 -0.63 -0.52 -0.42 -0.43 -0.44 -0.41 0.53 0.51 32 46 51 52 53 58 60 64 65 66 67 68 69 72 73 74 75 76 77 78 79 80 81 82 72 module 72 15 0 2 1 1 60.68 37.04 665 1120 614 615 589 590 591 592 593 594 595 596 597 598 599 600 601 602 603 604 605 606 607 608 609 610 611 612 613 1104 587 588 49 50 1019 1020 1021 976 921 922 923 895 893 426 427 578 579 580 581 582 577 995 909 910 911 912 935 616 617 618 619 924 925 926 39 41 40 42 43 1038 567 568 569 570 571 572 573 574 575 576 252 253 254 981 990 560 561 562 563 564 565 465 900 901 879 48 442 583 584 585 586 519 520 521 522 523 524 525 526 527 528 529 530 424 425 1027 559 440 1113 1026 883 756 735 746 747 1116 904 566 464 1118 1107 892 975 1029 1047 13 551 552 553 554 555 556 557 558 914 913 669 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 -0.66 0.65 -0.72 0.72 -0.63 -0.75 -0.63 0.68 0.71 0.66 -0.66 -0.72 0.72 0.69 -0.74 0.65 -0.69 -0.67 0.64 0.66 0.71 0.76 0.66 0.75 -0.71 0.69 0.73 -0.67 -0.70 -0.74 0.73 0.77 -0.78 -0.77 -0.76 -0.76 -0.76 0.89 0.84 0.86 0.82 0.89 0.82 0.82 0.77 0.84 0.76 0.78 -0.77 0.82 0.78 0.90 0.88 0.97 0.88 0.98 0.87 0.87 0.94 -0.85 0.90 0.95 0.98 1.00 -0.87 -0.89 -0.86 -0.93 -0.96 0.87 -0.81 -0.83 -0.81 -0.91 -0.83 -0.83 -0.85 0.85 -0.84 0.85 0.85 0.89 0.93 -0.81 0.81 -0.76 -0.73 0.79 -0.74 0.75 -0.74 -0.72 0.77 0.78 -0.72 -0.75 0.68 -0.77 0.78 0.72 0.76 -0.69 -0.64 0.71 0.69 0.72 0.70 0.73 -0.66 -0.74 -0.71 0.77 -0.65 0.70 0.68 -0.75 0.70 0.76 0.89 0.85 -0.66 0.74 0.68 0.69 -0.66 -0.65 -0.66 0.79 0.91 -0.67 0.92 0.75 0.64 -0.67 0.82 0.64 -0.66 0.67 0.69 0.64 0.66 0.65 0.66 -0.66 0.73 0.73 0.63 0.65 -0.67 0.64 -0.67 -0.65 -0.70 0.66 -0.66 0.64 0.64 0.76 -0.66 -0.69 0.69 0.68 -0.63 0.69 -0.63 -0.66 51 47 66 13 120 101 122 106 121 98 111 112 108 96 110 119 117 103 52 107 113 118 104 105 99 124 123 114 2 100 115 92 116 128 97 109 125 94 102 72 31 0.78 -0.26 0.79 -0.20 -0.41 -0.50 -0.35 -0.51 -0.53 -0.62 -0.35 -0.53 -0.53 -0.53 -0.76 -0.59 -0.53 -0.57 -0.53 1.00 -0.72 -0.28 -0.52 -0.52 -0.43 -0.45 -0.57 -0.60 -0.29 -0.30 -0.52 -0.45 -0.41 -0.41 0.89 0.96 0.89 0.83 -0.22 0.84 0.85 3 11 27 32 34 35 36 46 50 51 52 53 60 64 65 66 68 69 71 73 74 75 76 77 78 79 80 81 82 1 GO:0002684 positive regulation of immune system process BP 5.85e-04 5.43 4.11 17 86 2 GO:0006955 immune response BP 1.09e-03 3.35 10.98 29 230 3 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II BP 1.45e-03 41.57 0.43 6 9 4 GO:0023052 signaling BP 1.68e-03 2.33 42.02 69 880 5 GO:0002376 immune system process BP 2.68e-03 2.79 16.85 37 353 6 GO:0032502 developmental process BP 3.47e-03 2.34 34.14 59 715 7 GO:0050776 regulation of immune response BP 0.01 5.04 3.53 14 74 8 GO:0002682 regulation of immune system process BP 0.01 3.81 6.16 19 129 9 GO:0050778 positive regulation of immune response BP 0.01 6.51 2.24 11 47 10 GO:0007275 multicellular organismal development BP 0.02 2.26 29.89 52 626 11 GO:0051251 positive regulation of lymphocyte activation BP 0.02 6.33 2.29 11 48 12 GO:0007154 cell communication BP 0.02 2.58 16.81 35 352 13 GO:0048856 anatomical structure development BP 0.03 2.24 27.93 49 585 14 GO:0002696 positive regulation of leukocyte activation BP 0.03 5.85 2.43 11 51 15 GO:0048731 system development BP 0.03 2.28 24.87 45 521 16 GO:0051249 regulation of lymphocyte activation BP 0.04 5.23 2.91 12 61 17 GO:0002768 immune response-regulating cell surface receptor signaling pathway BP 0.04 8.83 1.29 8 27 18 GO:0032946 positive regulation of mononuclear cell proliferation BP 0.04 8.83 1.29 8 27 19 GO:0050671 positive regulation of lymphocyte proliferation BP 0.04 8.83 1.29 8 27 20 GO:0070665 positive regulation of leukocyte proliferation BP 0.04 8.83 1.29 8 27 21 GO:0032944 regulation of mononuclear cell proliferation BP 0.04 7.29 1.67 9 35 22 GO:0050670 regulation of lymphocyte proliferation BP 0.04 7.29 1.67 9 35 23 GO:0070663 regulation of leukocyte proliferation BP 0.04 7.29 1.67 9 35 24 GO:0050850 positive regulation of calcium-mediated signaling BP 0.05 25.79 0.43 5 9 25 GO:0050867 positive regulation of cell activation BP 0.05 5.57 2.53 11 53 26 GO:0005886 plasma membrane CC 2.80e-07 2.96 31.09 63 647 27 GO:0044459 plasma membrane part CC 4.91e-07 3.36 18.31 45 381 28 GO:0044425 membrane part CC 4.14e-05 2.43 43.58 73 907 29 GO:0042101 T cell receptor complex CC 7.41e-05 61.88 0.38 6 8 30 GO:0042613 MHC class II protein complex CC 1.19e-03 51.21 0.34 5 7 31 GO:0042611 MHC protein complex CC 9.92e-03 13.72 0.72 6 15 32 GO:0031224 intrinsic to membrane CC 0.01 2.06 33.92 55 706 33 GO:0016021 integral to membrane CC 0.02 2.05 33.39 54 695 34 GO:0016020 membrane CC 0.02 1.91 58.23 81 1212 35 GO:0042105 alpha-beta T cell receptor complex CC 0.03 Inf 0.14 3 3 36 GO:0004871 signal transducer activity MF 3.80e-06 3.38 15.88 40 342 37 GO:0060089 molecular transducer activity MF 3.80e-06 3.38 15.88 40 342 38 GO:0004888 transmembrane receptor activity MF 6.49e-05 4.86 5.34 20 115 39 GO:0004872 receptor activity MF 1.63e-04 3.68 8.96 26 193 1 05320 Autoimmune thyroid disease 1.17e-03 19.55 0.63 6 12 2 05330 Allograft rejection 2.05e-03 16.75 0.68 6 13 3 05340 Primary immunodeficiency 4.94e-03 9.86 1.10 7 21 4 05332 Graft-versus-host disease 5.39e-03 13.00 0.79 6 15 5 05310 Asthma 6.49e-03 19.29 0.52 5 10 6 04940 Type I diabetes mellitus 8.08e-03 11.70 0.84 6 16 7 04672 Intestinal immune network for IgA production 0.04 10.68 0.73 5 14 8 04660 T cell receptor signaling pathway 0.04 4.28 2.99 10 57 73 module 73 11 0 2 1 1 44.73 37.04 407 443 1050 861 259 1024 987 978 701 1117 264 265 1087 969 1039 1084 880 1115 417 756 1119 782 1035 760 862 863 800 801 970 774 775 776 757 758 759 783 784 785 786 1125 1126 761 762 763 764 1036 766 767 768 755 771 772 773 748 749 742 736 737 796 797 798 799 777 778 779 780 781 735 746 747 769 770 738 739 751 1121 765 750 753 740 754 741 743 744 883 1086 752 1127 734 1122 1054 1101 804 745 1116 1118 1026 1113 464 1029 559 982 463 -0.79 0.76 0.75 -0.79 0.78 0.81 -0.86 0.74 0.79 -0.83 -0.80 -0.80 0.74 0.74 -0.81 -0.80 -0.81 0.76 -0.90 0.82 0.81 -0.85 -0.82 0.82 -0.80 -0.80 -0.84 0.76 -0.90 0.76 0.75 0.77 0.85 -0.84 0.84 -0.82 -0.86 -0.79 0.76 0.77 -0.85 -0.85 -0.89 0.81 0.82 0.79 -0.89 -0.90 0.85 0.79 -0.98 -0.96 -0.95 -0.88 -1.00 -0.87 0.99 -0.96 0.88 0.91 -0.91 -0.88 -0.96 0.88 0.95 0.91 0.84 0.98 0.89 -0.92 -0.83 -0.85 -0.84 -0.84 0.84 0.80 -0.86 0.83 0.93 -0.89 -0.87 0.81 0.77 0.75 -0.91 0.78 0.86 0.82 0.81 0.75 -0.83 0.80 0.83 0.91 -0.89 -0.83 0.76 0.79 0.85 -0.84 0.76 0.76 -0.79 29 19 3 62 68 49 47 57 48 46 82 60 53 54 23 85 56 55 79 50 88 51 52 103 117 124 113 104 118 107 119 114 110 99 123 105 31 17 -0.43 -0.44 -0.43 0.46 0.57 0.50 -0.65 0.68 0.56 0.66 0.68 0.74 0.79 1.00 0.80 0.87 0.76 0.83 0.67 0.64 0.67 0.64 -0.74 -0.63 -0.59 -0.62 -0.65 -0.52 -0.49 0.78 -0.72 -0.62 -0.44 -0.48 -0.49 -0.50 0.51 0.43 32 46 51 53 60 64 65 66 67 68 69 71 72 74 75 76 77 78 79 80 81 82 74 module 74 16 0 2 1 1 45.49 37.04 1045 703 970 1039 1080 518 702 1124 440 680 944 1035 982 755 1121 1024 1050 883 1118 1122 1116 804 765 1054 1101 417 756 743 744 1086 766 767 768 757 758 759 748 749 751 771 772 773 742 754 752 740 769 770 750 736 737 753 735 796 797 798 799 777 778 779 780 781 745 746 747 738 739 741 734 1127 733 710 701 398 408 409 410 708 725 718 259 889 960 956 1128 904 1113 566 464 935 1026 1038 1107 -0.82 -0.84 -0.84 -0.82 -0.82 0.72 0.74 0.80 0.74 0.80 -0.82 -0.83 0.75 0.77 0.80 0.76 0.77 -0.89 -0.82 0.81 -0.91 0.77 -0.95 -0.90 0.84 -0.99 0.78 0.78 0.72 0.76 -0.85 -0.86 0.72 0.77 -0.89 0.77 -0.89 -1.00 0.90 -0.94 -0.93 -0.93 -0.92 -0.87 0.86 -0.90 -0.89 -0.85 0.76 0.93 -0.94 0.99 0.93 0.82 0.87 -0.98 -0.94 -0.99 0.93 0.94 0.94 0.89 0.89 0.85 -0.97 -0.87 -0.87 0.75 0.87 0.83 0.75 0.79 0.89 -0.84 -0.86 -0.85 -0.84 0.83 0.79 0.74 0.76 -0.84 -0.91 -0.83 0.80 -0.86 0.81 0.77 0.84 0.74 0.79 0.75 0.72 68 25 43 44 45 42 62 49 88 50 79 23 85 56 55 53 54 46 82 60 48 57 51 47 107 119 113 52 117 103 99 114 110 123 105 124 104 118 100 2 115 96 17 0.60 -0.36 0.64 0.65 0.52 0.55 0.54 0.68 0.67 0.91 0.82 0.97 1.00 0.78 0.95 0.86 0.97 0.70 0.69 0.88 0.69 0.76 0.79 -0.61 0.78 -0.64 -0.60 -0.72 -0.61 -0.69 -0.56 -0.57 -0.48 -0.48 -0.53 -0.61 -0.60 -0.45 -0.37 -0.41 -0.35 -0.38 0.54 32 46 51 52 53 56 57 58 60 61 64 65 66 67 68 69 71 72 73 75 76 77 78 79 80 81 82 1 GO:0019955 cytokine binding MF 0.02 10.76 0.74 6 28 75 module 75 9 0 2 1 1 42.71 37.04 993 861 1089 1090 1087 802 803 1083 639 640 1084 264 265 987 978 804 1117 1035 782 1125 1126 970 760 1119 738 739 1086 766 767 768 756 757 758 759 765 1121 740 754 771 772 773 752 751 745 769 770 746 747 735 736 737 750 753 777 778 779 780 781 796 797 798 799 742 748 749 743 744 755 1036 800 801 761 762 763 764 774 775 776 57 788 789 790 791 792 793 794 795 783 784 785 786 862 863 787 741 883 1041 559 1118 1042 476 475 1109 431 432 433 0.77 0.75 0.79 -0.74 -0.75 0.80 0.82 0.76 0.77 0.77 0.77 0.78 0.79 0.84 -0.73 -0.84 0.77 0.83 0.84 -0.80 0.83 0.91 -0.79 -0.84 0.88 0.83 -0.82 0.84 0.92 -0.89 -0.78 -0.87 0.76 -0.84 0.80 -0.78 0.79 0.83 0.90 0.94 0.91 -0.79 -0.85 -0.83 0.87 0.81 -0.86 0.85 -0.85 -0.97 1.00 -0.81 -0.85 0.92 -0.82 -0.86 -0.77 -0.81 -0.81 -0.87 0.86 0.83 0.89 0.89 0.98 -0.75 -0.77 -0.75 -0.81 0.90 -0.79 0.80 0.90 -0.77 -0.87 -0.80 -0.75 -0.78 0.76 0.84 0.81 0.75 -0.76 0.78 -0.80 0.81 -0.77 0.93 0.87 0.78 -0.80 0.77 0.81 -0.77 -0.80 0.82 0.79 -0.73 0.75 0.80 0.78 0.78 0.81 -0.74 -0.74 -0.74 31 99 117 114 113 119 107 52 54 53 23 85 56 55 46 82 60 51 79 50 88 48 57 47 124 49 103 68 62 3 19 29 8 89 102 35 76 -0.46 0.58 0.71 0.72 0.74 0.90 -0.71 0.83 -1.00 -0.72 -0.76 -0.81 -0.67 -0.75 -0.60 -0.60 -0.66 -0.57 -0.58 -0.48 -0.54 -0.49 -0.62 0.74 0.63 -0.42 0.65 -0.49 -0.41 0.62 0.58 0.64 0.59 -0.40 -0.41 0.58 -0.31 32 50 55 60 64 65 66 67 68 69 71 72 73 74 76 77 78 79 80 81 82 1 00240 Pyrimidine metabolism 3.54e-03 8.26 1.37 8 37 2 00230 Purine metabolism 8.35e-03 6.20 1.96 9 53 76 module 76 9 0 2 1 1 45.35 37.04 703 14 1031 1053 1083 889 1043 702 944 730 733 728 731 729 960 752 417 956 982 904 1128 1113 771 772 773 1101 754 1122 741 751 738 739 743 744 742 748 749 769 770 750 736 737 777 778 779 780 781 796 797 798 799 735 746 747 745 734 753 701 259 408 409 410 726 727 1084 398 732 24 710 719 720 721 722 723 724 643 644 645 646 712 713 714 715 716 983 258 718 708 1105 709 717 93 115 126 725 985 1127 711 1110 1116 740 0.83 0.83 0.86 0.83 0.84 0.87 0.93 -0.71 0.84 0.85 -0.74 0.94 0.85 -0.68 0.87 -0.68 0.88 0.89 -0.68 0.87 -0.69 -0.68 0.86 0.84 0.85 -0.76 0.87 -0.73 -0.75 -0.68 0.90 0.88 -0.74 -0.70 0.93 0.88 0.92 0.84 0.85 -0.71 -0.79 0.88 1.00 -0.91 -0.87 -0.85 -0.92 -0.74 -0.82 0.94 0.90 -0.76 -0.77 0.92 -0.78 -0.72 -0.97 -0.79 -0.75 0.88 0.89 0.93 0.90 0.89 0.89 0.88 0.87 0.89 -0.80 0.90 -0.73 -0.74 0.89 -0.72 -0.77 0.84 0.88 0.84 0.85 -0.68 0.90 -0.71 -0.71 0.86 -0.68 -0.70 -0.80 -0.93 -0.74 -0.77 -0.71 -0.69 -0.69 -0.75 -0.80 -0.70 -0.78 -0.68 0.83 0.89 0.90 3 68 105 104 118 99 107 119 113 103 117 124 47 52 51 57 48 46 82 60 23 85 56 55 54 53 79 50 88 49 62 25 45 43 44 42 40 41 33 32 26 10 0.57 -0.51 0.57 0.66 0.53 0.64 -0.63 0.47 0.57 0.76 0.50 0.64 0.57 0.75 -0.73 -0.64 -0.69 -0.57 -0.65 -0.73 -0.96 -0.96 -0.85 -0.97 -1.00 -0.82 -0.75 -0.97 -0.70 -0.64 -0.58 0.56 -0.67 -0.82 -0.88 -0.77 -0.73 -0.55 -0.60 0.43 0.65 0.55 32 39 40 41 42 43 45 46 47 51 53 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 77 78 79 80 81 82 77 module 77 12 0 2 1 1 60.15 37.04 406 242 51 1112 902 892 1027 1029 559 735 745 746 747 1116 417 1113 883 464 566 904 1026 756 440 1107 975 893 1120 1019 1020 1021 1047 895 1104 976 990 560 561 562 563 564 565 981 995 1038 42 43 39 41 40 567 568 569 570 571 572 573 574 575 576 252 253 254 924 925 926 935 616 617 618 619 909 910 911 912 577 578 579 580 581 582 583 584 585 586 442 48 879 519 520 521 522 523 524 525 526 527 528 529 530 465 900 901 424 425 589 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119 107 52 113 117 124 103 104 105 118 99 110 114 123 100 2 115 128 97 125 120 101 122 116 92 106 96 121 98 111 112 108 109 94 13 66 11 0.89 0.81 0.76 0.80 -0.32 -0.61 1.00 -0.58 -0.73 -0.59 -0.47 -0.62 -0.54 -0.53 -0.32 -0.40 -0.79 -0.63 -0.62 -0.33 -0.31 -0.54 -0.48 0.91 0.87 -0.44 -0.50 -0.35 -0.47 -0.43 -0.52 -0.55 -0.51 -0.62 -0.37 -0.54 -0.58 0.93 0.82 -0.26 0.82 0.76 3 11 21 27 32 34 35 36 46 50 51 52 53 60 64 65 66 68 69 71 72 73 74 75 76 78 79 80 81 82 1 GO:0006955 immune response BP 3.45e-04 3.68 9.85 28 230 2 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II BP 7.67e-04 46.84 0.39 6 9 3 GO:0032502 developmental process BP 1.84e-03 2.50 30.61 55 715 4 GO:0002684 positive regulation of immune system process BP 3.99e-03 5.21 3.68 15 86 5 GO:0002376 immune system process BP 4.09e-03 2.87 15.11 34 353 6 GO:0051251 positive regulation of lymphocyte activation BP 6.24e-03 7.17 2.05 11 48 7 GO:0002696 positive regulation of leukocyte activation BP 0.01 6.63 2.18 11 51 8 GO:0007275 multicellular organismal development BP 0.02 2.36 26.80 48 626 9 GO:0050867 positive regulation of cell activation BP 0.02 6.31 2.27 11 53 10 GO:0050776 regulation of immune response BP 0.02 5.18 3.17 13 74 11 GO:0032944 regulation of mononuclear cell proliferation BP 0.02 8.24 1.50 9 35 12 GO:0050670 regulation of lymphocyte proliferation BP 0.02 8.24 1.50 9 35 13 GO:0070663 regulation of leukocyte proliferation BP 0.02 8.24 1.50 9 35 14 GO:0032946 positive regulation of mononuclear cell proliferation BP 0.02 9.97 1.16 8 27 15 GO:0050671 positive regulation of lymphocyte proliferation BP 0.02 9.97 1.16 8 27 16 GO:0070665 positive regulation of leukocyte proliferation BP 0.02 9.97 1.16 8 27 17 GO:0048731 system development BP 0.02 2.42 22.30 42 521 18 GO:0048869 cellular developmental process BP 0.02 2.52 18.53 37 433 19 GO:0050850 positive regulation of calcium-mediated signaling BP 0.03 29.03 0.39 5 9 20 GO:0023052 signaling BP 0.03 2.18 37.67 60 880 21 GO:0030154 cell differentiation BP 0.03 2.53 17.29 35 404 22 GO:0048856 anatomical structure development BP 0.03 2.32 25.04 45 585 23 GO:0019882 antigen processing and presentation BP 0.04 10.97 0.94 7 22 24 GO:0002682 regulation of immune system process BP 0.04 3.75 5.52 17 129 25 GO:0050870 positive regulation of T cell activation BP 0.05 7.13 1.67 9 39 26 GO:0044459 plasma membrane part CC 6.36e-07 3.55 15.99 41 381 27 GO:0005886 plasma membrane CC 9.66e-06 2.84 27.15 54 647 28 GO:0044425 membrane part CC 1.12e-05 2.68 38.06 67 907 29 GO:0042101 T cell receptor complex CC 3.06e-05 71.74 0.34 6 8 30 GO:0042613 MHC class II protein complex CC 5.66e-04 59.31 0.29 5 7 31 GO:0043235 receptor complex CC 6.43e-04 8.44 1.64 10 39 32 GO:0031224 intrinsic to membrane CC 3.05e-03 2.27 29.62 51 706 33 GO:0042611 MHC protein complex CC 4.21e-03 15.90 0.63 6 15 34 GO:0016021 integral to membrane CC 4.41e-03 2.25 29.16 50 695 35 GO:0016020 membrane CC 5.10e-03 2.11 50.86 74 1212 36 GO:0009897 external side of plasma membrane CC 9.83e-03 5.80 2.18 10 52 37 GO:0042105 alpha-beta T cell receptor complex CC 0.02 Inf 0.13 3 3 38 GO:0031226 intrinsic to plasma membrane CC 0.05 2.65 9.82 22 234 39 GO:0004871 signal transducer activity MF 1.23e-05 3.45 14.00 36 342 40 GO:0060089 molecular transducer activity MF 1.23e-05 3.45 14.00 36 342 41 GO:0004872 receptor activity MF 7.60e-04 3.65 7.90 23 193 42 GO:0004888 transmembrane receptor activity MF 4.68e-03 4.19 4.71 16 115 1 05320 Autoimmune thyroid disease 1.09e-03 20.16 0.61 6 12 2 05330 Allograft rejection 1.92e-03 17.27 0.66 6 13 3 05340 Primary immunodeficiency 4.53e-03 10.17 1.07 7 21 4 05332 Graft-versus-host disease 5.06e-03 13.41 0.77 6 15 5 05310 Asthma 6.25e-03 19.88 0.51 5 10 6 04940 Type I diabetes mellitus 7.61e-03 12.06 0.82 6 16 7 04672 Intestinal immune network for IgA production 0.04 11.01 0.71 5 14 78 module 78 13 0 2 1 1 46.16 37.04 986 1036 1044 1118 1128 702 440 1035 982 1113 1038 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