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DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

chromosome segregation

The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.

chromosome organization

A process that is carried out at the cellular level that results in the formation, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information.

mitotic sister chromatid segregation

The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.

cell cycle checkpoint

The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.

DNA replication checkpoint

A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

mitotic cell cycle

Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.

M phase

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.

nuclear division

A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.

DNA synthesis during DNA repair

Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

cellular alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

DNA-dependent DNA replication

The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

DNA replication initiation

The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

nucleotide-excision repair

In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).

nucleotide-excision repair, DNA gap filling

Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes.

double-strand break repair

The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

DNA packaging

Any process by which DNA and associated proteins are formed into a compact, orderly structure.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

cholesterol biosynthetic process

The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

response to DNA damage stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

organelle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

microtubule-based process

Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

spindle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

mitotic chromosome condensation

The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

intracellular signaling cascade

A series of reactions within the cell that occur as a result of a single trigger reaction or compound.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

response to radiation

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

response to abiotic stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.

regulation of biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

negative regulation of biosynthetic process

Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to ionizing radiation

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of macromolecule biosynthetic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cell cycle process

Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cellular component organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cellular component.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

second-messenger-mediated signaling

A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell.

phosphoinositide-mediated signaling

A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

regulation of DNA replication initiation

Any process that modulates the frequency, rate or extent of initiation of DNA replication; the process by which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.

chromosome condensation

The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

negative regulation of cellular biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

DNA integrity checkpoint

Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure.

negative regulation of DNA replication initiation

Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular response to DNA damage stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

organelle fission

The creation of two or more organelles by division of one organelle.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of DNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

cell division

The process resulting in the physical partitioning and separation of a cell into daughter cells.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

interphase

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

interphase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

all

This term is the most general term possible

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biosynthetic process

Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.

regulation of biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

negative regulation of biosynthetic process

Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of macromolecule biosynthetic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

negative regulation of cellular biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

negative regulation of macromolecule biosynthetic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of cellular biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

regulation of cell cycle process

Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

cellular response to DNA damage stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

negative regulation of macromolecule biosynthetic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

negative regulation of cellular biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

regulation of DNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

regulation of DNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

mitotic chromosome condensation

The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

mitotic chromosome condensation

The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

chromosome condensation

The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

spindle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

mitotic sister chromatid segregation

The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

interphase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

cholesterol biosynthetic process

The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

regulation of DNA replication initiation

Any process that modulates the frequency, rate or extent of initiation of DNA replication; the process by which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.

negative regulation of DNA replication initiation

Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication.

DNA synthesis during DNA repair

Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

negative regulation of DNA replication initiation

Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication.

DNA replication checkpoint

A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.

DNA replication initiation

The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

nucleotide-excision repair, DNA gap filling

Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

condensed chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosome, centromeric region

The region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

replication fork

The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

alpha DNA polymerase:primase complex

A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.

chromosome

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

membrane-enclosed lumen

The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

protein-DNA complex

A macromolecular complex containing both protein and DNA molecules.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

all

This term is the most general term possible

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

alpha DNA polymerase:primase complex

A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

alpha DNA polymerase:primase complex

A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.

nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nucleotide binding

Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.

protein binding

Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

G-protein-coupled receptor binding

Interacting selectively with a G-protein-coupled receptor.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

nucleic acid binding

Interacting selectively with any nucleic acid.

DNA binding

Interacting selectively with DNA (deoxyribonucleic acid).

DNA helicase activity

Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix.

ATPase activity, coupled

Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane.

motor activity

Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate.

microtubule motor activity

Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

nucleoside-triphosphatase activity

Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.

receptor binding

Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

helicase activity

Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix.

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

ATP binding

Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

chemokine activity

The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

DNA-dependent ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction.

ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction.

pyrophosphatase activity

Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

hydrolase activity, acting on acid anhydrides

Catalysis of the hydrolysis of any acid anhydride.

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.

purine nucleotide binding

Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate.

adenyl nucleotide binding

Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.

ribonucleotide binding

Interacting selectively with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

purine ribonucleotide binding

Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

adenyl ribonucleotide binding

Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

chemokine receptor binding

Interacting selectively with any chemokine receptor.

all

This term is the most general term possible

purine ribonucleotide binding

Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

adenyl ribonucleotide binding

Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

chemokine activity

The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022403	2.763e-32	19.53	87 ASPM, AURKA, AURKB, BIRC5, BLM, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN3, CDT1, CENPE, CENPF, CEP55, CHEK1, DBF4, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, EXO1, FBXO5, GTSE1, HELLS, IL1A, IL1B, INHBA, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, MPHOSPH9, MRE11A, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, POLA1, POLD1, POLE, PRC1, PSMC3IP, PTTG1, RAD54B, RAD54L, SMC2, SMC4, SPAG5, SPC25, STMN1, TACC3, TIMELESS, TIPIN, TPD52L1, TPX2, TTK, UBE2C, WEE1, ZWILCH, ZWINT	285	cell cycle phase
GO:0000279	2.087e-30	15.76	76 ASPM, AURKA, AURKB, BIRC5, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, CHEK1, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, EXO1, FBXO5, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, MPHOSPH9, MRE11A, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PRC1, PSMC3IP, PTTG1, RAD54B, RAD54L, SMC2, SMC4, SPAG5, SPC25, STMN1, TACC3, TIMELESS, TIPIN, TPX2, TTK, UBE2C, WEE1, ZWILCH, ZWINT	230	M phase
GO:0000087	6.792e-29	12.06	65 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, FBXO5, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, MPHOSPH9, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PTTG1, SMC2, SMC4, SPAG5, SPC25, TIMELESS, TIPIN, TPX2, UBE2C, WEE1, ZWILCH, ZWINT	176	M phase of mitotic cell cycle
GO:0000280	1.813e-28	11.85	64 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, FBXO5, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PTTG1, SMC2, SMC4, SPAG5, SPC25, TIMELESS, TIPIN, TPX2, UBE2C, WEE1, ZWILCH, ZWINT	173	nuclear division
GO:0007067	1.813e-28	11.85	64 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, FBXO5, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PTTG1, SMC2, SMC4, SPAG5, SPC25, TIMELESS, TIPIN, TPX2, UBE2C, WEE1, ZWILCH, ZWINT	173	mitosis
GO:0048285	1.782e-27	12.26	64 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, FBXO5, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PTTG1, SMC2, SMC4, SPAG5, SPC25, TIMELESS, TIPIN, TPX2, UBE2C, WEE1, ZWILCH, ZWINT	179	organelle fission
GO:0007049	3.129e-26	44.26	125 ASPM, AURKA, AURKB, BARD1, BIRC5, BLM, BMP2, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, C13orf15, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNE2, CCNF, CDC2, CDC20, CDC25A, CDC45L, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN3, CDT1, CENPE, CENPF, CEP55, CHAF1A, CHAF1B, CHEK1, CKAP2, CKS1B, CP110, DBF4, DDX11, DDX12, DLGAP5, DSCC1, DSN1, E2F8, ERCC6L, ESPL1, EXO1, FANCG, FANCI, FBXO5, GMNN, GTSE1, HELLS, IL1A, IL1B, IL8, INHBA, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, LIG1, MAD2L1, MAF, MAP3K8, MCM2, MCM3, MCM6, MCM7, MKI67, MPHOSPH9, MRE11A, MSH2, MTSS1, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PLK3, POLA1, POLD1, POLE, PRC1, PSMC3IP, PSRC1, PTTG1, RACGAP1, RAD54B, RAD54L, RAD9A, RBL1, RGS2, SMC2, SMC4, SPAG5, SPC25, STMN1, SUV39H1, TACC3, TIMELESS, TIPIN, TP53BP2, TPD52L1, TPX2, TTK, UBE2C, WEE1, ZWILCH, ZWINT	646	cell cycle
GO:0022402	4.687e-26	26.86	94 ASPM, AURKA, AURKB, BARD1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN3, CDT1, CENPE, CENPF, CEP55, CHEK1, CP110, DBF4, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, EXO1, FBXO5, GTSE1, HELLS, IL1A, IL1B, IL8, INHBA, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, MPHOSPH9, MRE11A, MSH2, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, POLA1, POLD1, POLE, PRC1, PSMC3IP, PTTG1, RACGAP1, RAD54B, RAD54L, SMC2, SMC4, SPAG5, SPC25, STMN1, TACC3, TIMELESS, TIPIN, TPD52L1, TPX2, TTK, UBE2C, WEE1, ZWILCH, ZWINT	392	cell cycle process
GO:0000278	3.905e-25	21.44	82 ASPM, AURKA, AURKB, BIRC5, BLM, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN3, CDT1, CENPE, CENPF, CEP55, CHEK1, DBF4, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, FBXO5, GTSE1, HELLS, IL1A, IL1B, INHBA, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, MPHOSPH9, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, POLA1, POLD1, POLE, PRC1, PTTG1, SMC2, SMC4, SPAG5, SPC25, STMN1, TIMELESS, TIPIN, TPD52L1, TPX2, TTK, UBE2C, WEE1, ZWILCH, ZWINT	313	mitotic cell cycle
GO:0051301	9.714e-24	13.15	62 ASPM, AURKB, BLM, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNE2, CCNF, CDC2, CDC20, CDC25A, CDC6, CDC7, CDCA3, CDCA8, CDK2, CENPE, CENPF, CENPO, CEP55, CKS1B, CP110, DSN1, ERCC6L, ESPL1, FBXO5, HELLS, KIF11, KIF20B, KIF23, KNTC1, LIG1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PLK1, PRC1, PTTG1, RACGAP1, SMC2, SMC4, SPAG5, SPC25, TIMELESS, TIPIN, UBE2C, WEE1, ZWILCH, ZWINT	192	cell division
GO:0006260	3.625e-21	12.33	57 AREG, BLM, BRCA1, BRCA2, CDC25A, CDC45L, CDC6, CDC7, CDK2, CDT1, CHAF1A, CHAF1B, CHEK1, DBF4, DNA2, DSCC1, DTL, EXO1, FEN1, GINS1, GINS2, GINS3, GINS4, GMNN, HMGB2, LIG1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MRE11A, MSH2, ORC1L, ORC6L, PDGFA, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, RAD9A, RFC2, RFC3, RFC4, RMI1, RNASEH2A, RPA3, SUPT16H, TIPIN, TK1, TOP2A	180	DNA replication
GO:0006259	1.615e-15	25.42	75 AREG, BLM, BRCA1, BRCA2, BRIP1, CDC25A, CDC45L, CDC6, CDC7, CDK2, CDT1, CHAF1A, CHAF1B, CHEK1, DBF4, DNA2, DNASE2, DSCC1, DTL, EXO1, FANCA, FANCG, FANCI, FEN1, GINS1, GINS2, GINS3, GINS4, GMNN, HELLS, HMGB2, LIG1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MRE11A, MSH2, MYC, NEIL3, ORC1L, ORC6L, PARP2, PDGFA, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, PSMC3IP, PTTG1, RAD51AP1, RAD54B, RAD54L, RAD9A, RECQL4, RFC2, RFC3, RFC4, RMI1, RNASEH2A, RPA3, SOD2, SUPT16H, TIPIN, TK1, TOP2A, TOPBP1, UNG	371	DNA metabolic process
GO:0007059	1.946e-09	3.151	20 BRCA1, CENPE, CENPF, CENPO, DDX11, DLGAP5, DSN1, ESPL1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1, PTTG1, SMC2, SMC4, TOP2A, ZWINT	46	chromosome segregation
GO:0006996	2.834e-09	61.25	114 ASF1B, ASPM, AURKA, AURKB, BBS1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC6, CDCA3, CDCA8, CDK2, CDYL, CENPA, CENPE, CENPF, CEP55, CHAF1A, CHAF1B, CP110, CPA4, CTSD, CXCL1, DAAM2, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, EXOSC8, EXOSC9, EZH2, FANCG, FBXO5, GAA, HELLS, HIRIP3, HMGB2, IL1A, IL1B, JMJD3, JMJD6, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, MAD2L1, MCM2, MRE11A, MSH2, MTSS1, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NR3C1, NUSAP1, OIP5, OPTN, PBK, PDGFA, PKMYT1, PLK1, PRC1, PRKG1, PSRC1, PTTG1, RACGAP1, RAD54L, RBL1, RCL1, SMC2, SMC4, SOD2, SPAG5, SPC25, STMN1, SUPT16H, SUV39H1, TACC3, TIMELESS, TIPIN, TMEM48, TOP2A, TPP1, TPX2, TTK, UBE2C, WEE1, WHSC1, WNT2, ZWILCH, ZWINT	894	organelle organization
GO:0000075	4.664e-09	3.631	21 BLM, BRIP1, BUB1, BUB1B, CCNA2, CCNE2, CDC45L, CDC6, CDT1, CENPF, CHEK1, FANCG, GTSE1, KNTC1, MAD2L1, MSH2, RAD9A, TIPIN, TTK, ZWILCH, ZWINT	53	cell cycle checkpoint
GO:0000070	9.097e-09	1.576	14 CENPE, DDX11, DLGAP5, ESPL1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1, SMC2, SMC4, ZWINT	23	mitotic sister chromatid segregation
GO:0006270	1.425e-08	1.37	13 CDC45L, CDC6, CDT1, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, ORC1L, POLA1, RAD9A, TIPIN	20	DNA replication initiation
GO:0000819	1.927e-08	1.644	14 CENPE, DDX11, DLGAP5, ESPL1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1, SMC2, SMC4, ZWINT	24	sister chromatid segregation
GO:0051726	3.619e-08	17.61	48 BLM, BMP2, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, C13orf15, CCNA2, CCNE2, CDC25A, CDC45L, CDC6, CDC7, CDK2, CDKN3, CDT1, CENPF, CHEK1, CKS1B, DLGAP5, ESPL1, FANCG, GMNN, GTSE1, IL1A, IL1B, INHBA, KIF20B, KNTC1, MAD2L1, MAF, MSH2, MTSS1, MYC, NEK2, NUSAP1, PKMYT1, RAD9A, RBL1, TACC3, TIMELESS, TIPIN, TP53BP2, TTK, UBE2C, ZWILCH, ZWINT	257	regulation of cell cycle
GO:0006261	8.651e-08	4.179	21 CDC45L, CDC6, CDT1, EXO1, HMGB2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MSH2, ORC1L, POLA1, POLD3, POLE2, PRIM1, RAD9A, RFC3, RFC4, TIPIN	61	DNA-dependent DNA replication
GO:0007017	9.116e-08	9.18	32 AURKA, BBS1, BRCA1, BRCA2, BUB1B, CENPE, CP110, ESPL1, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, NDC80, NEK2, NUSAP1, PRC1, PSRC1, SPAG5, STMN1, TACC3, TTK, UBE2C, WNT2, ZWINT	134	microtubule-based process
GO:0007346	1.314e-07	5.96	25 BLM, BRCA2, BUB1, BUB1B, CCNA2, CDC6, CDK2, CDT1, CENPF, DLGAP5, ESPL1, GTSE1, IL1A, IL1B, KIF20B, KNTC1, MAD2L1, MYC, NEK2, NUSAP1, PKMYT1, TTK, UBE2C, ZWILCH, ZWINT	87	regulation of mitotic cell cycle
GO:0006974	2.097e-07	17.95	47 BARD1, BLM, BRCA1, BRCA2, BRIP1, CCNA2, CHAF1A, CHAF1B, CHEK1, DTL, EXO1, FANCA, FANCG, FANCI, FEN1, GTSE1, HMGB2, HMOX1, LIG1, MCM7, MRE11A, MSH2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51AP1, RAD54B, RAD54L, RAD9A, RECQL4, RFC2, RFC3, RFC4, RPA3, SOD2, SUPT16H, TIMELESS, TIPIN, TOP2A, TOPBP1, UNG	262	response to DNA damage stimulus
GO:0008283	3.428e-07	38.3	77 ANG, AREG, BLM, BMP2, BMPR2, BNC1, BRCA1, BRCA2, BUB1, BUB1B, CCL2, CDC25A, CDC6, CDC7, CDK2, CDKN3, CENPF, CHEK1, CKS1B, CREG1, CXCL1, DDX11, DHCR7, DLGAP5, FABP3, FGF1, FGF2, FGF7, GINS1, GPNMB, HBEGF, HMOX1, HTR2A, IFITM1, IL11, IL15RA, IL1A, IL1B, IL6, IL8, INSIG1, JARID2, KIF15, KIF2C, LIF, LRP1, MCM7, MKI67, MYC, NAMPT, OSMR, PDGFA, PDGFD, PDGFRB, PLK1, POLA1, PPARD, PTGES, PTHLH, SERPINF1, SOD2, SOX4, SOX9, STIL, TACC3, TACSTD2, TGFBR1, TIMELESS, TIPIN, TNFSF4, TNFSF9, TNS3, TPX2, TRIB1, TTK, VEGFA, WNT2	559	cell proliferation
GO:0034984	4.556e-07	15.96	43 BLM, BRCA1, BRCA2, BRIP1, CCNA2, CHAF1A, CHAF1B, CHEK1, EXO1, FANCA, FANCG, FANCI, FEN1, GTSE1, HMGB2, HMOX1, LIG1, MRE11A, MSH2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51AP1, RAD54B, RAD54L, RAD9A, RECQL4, RFC2, RFC3, RFC4, RPA3, SOD2, SUPT16H, TIPIN, TOP2A, TOPBP1, UNG	233	cellular response to DNA damage stimulus
GO:0007051	5.351e-07	1.713	13 AURKA, BUB1B, ESPL1, KIF11, KIF23, NDC80, PRC1, SPAG5, STMN1, TACC3, TTK, UBE2C, ZWINT	25	spindle organization
GO:0006950	7.302e-07	57.75	102 ANG, ANGPTL4, BARD1, BLM, BMP2, BMP6, BRCA1, BRCA2, BRIP1, C1R, C1RL, C1S, CCL11, CCL2, CCL7, CCNA2, CD55, CHAF1A, CHAF1B, CHEK1, CHST2, CTSD, CXCL1, CXCL2, CXCL3, CXCL6, DPP4, DTL, EXO1, F10, F3, FADS1, FANCA, FANCG, FANCI, FEN1, FGF7, GCH1, GTSE1, HBEGF, HMGB2, HMOX1, HSPB3, HTR2A, IL1A, IL1B, IL1RAP, IL1RL1, IL6, IL8, INHBA, JMJD3, LIG1, LYST, MAFF, MAP2K3, MAP3K4, MCM7, MRE11A, MSH2, NEIL3, NFKB1, NINJ1, OSMR, P2RX4, PARP2, PDGFA, PLA2G4C, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PPARD, PROS1, PTTG1, RAD51AP1, RAD54B, RAD54L, RAD9A, RECQL4, RFC2, RFC3, RFC4, RPA3, SGK1, SOD2, SRF, SUPT16H, TACC3, THBD, TICAM1, TIMELESS, TIPIN, TNFAIP6, TOP2A, TOPBP1, TPST1, TRIB1, UNG, VEGFA	843	response to stress
GO:0006281	8.039e-07	13.91	39 BLM, BRCA1, BRCA2, BRIP1, CHAF1A, CHAF1B, CHEK1, EXO1, FANCA, FANCG, FANCI, FEN1, HMGB2, LIG1, MRE11A, MSH2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51AP1, RAD54B, RAD54L, RAD9A, RECQL4, RFC2, RFC3, RFC4, RPA3, SOD2, SUPT16H, TOP2A, TOPBP1, UNG	203	DNA repair
GO:0000226	1.447e-06	5.275	22 AURKA, BBS1, BRCA1, BRCA2, BUB1B, CP110, ESPL1, KIF11, KIF23, KIF2C, NDC80, NEK2, NUSAP1, PRC1, PSRC1, SPAG5, STMN1, TACC3, TTK, UBE2C, WNT2, ZWINT	77	microtubule cytoskeleton organization
GO:0009611	1.413e-05	15.48	39 BMP2, BMP6, C1R, C1RL, C1S, CCL11, CCL2, CCL7, CD55, CHST2, CXCL1, CXCL2, CXCL3, CXCL6, F10, F3, FGF7, HBEGF, HMOX1, IL1A, IL1B, IL1RAP, IL6, IL8, JMJD3, MAP2K3, NFKB1, NINJ1, OSMR, PDGFA, PLA2G4C, PPARD, PROS1, SOD2, SRF, THBD, TICAM1, TNFAIP6, TPST1	226	response to wounding
GO:0009605	2.132e-05	24.94	53 ADIPOR2, AQP3, BHLHE40, BMP2, BMP6, BRCA2, C1R, C1RL, C1S, CCL11, CCL2, CCL7, CD55, CHST2, CTSD, CXCL1, CXCL2, CXCL3, CXCL6, EGR2, F10, F3, FADS1, FGF2, FGF7, HBEGF, HMOX1, HSD17B2, IL1A, IL1B, IL1RAP, IL6, IL8, INHBA, ITGA1, JMJD3, MAP2K3, MYC, NFKB1, NINJ1, NR4A3, OSMR, PDGFA, PLA2G4C, PPARD, PROS1, SOD2, SRF, THBD, TICAM1, TNFAIP6, TPST1, VEGFA	364	response to external stimulus
GO:0030261	2.647e-05	1.028	9 NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NUSAP1, SMC2, SMC4, TOP2A	15	chromosome condensation
GO:0010564	3.385e-05	3.494	16 BRCA1, BRCA2, CDC7, CDT1, DLGAP5, ESPL1, IL1A, IL1B, KIF20B, KNTC1, NEK2, NUSAP1, PKMYT1, TIMELESS, TIPIN, UBE2C	51	regulation of cell cycle process
GO:0033554	3.452e-05	21.92	48 BLM, BRCA1, BRCA2, BRIP1, CCNA2, CHAF1A, CHAF1B, CHEK1, CTSD, EXO1, FADS1, FANCA, FANCG, FANCI, FEN1, GTSE1, HMGB2, HMOX1, IL1B, LIG1, MAP3K4, MRE11A, MSH2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51AP1, RAD54B, RAD54L, RAD9A, RECQL4, RFC2, RFC3, RFC4, RPA3, SOD2, SUPT16H, TIPIN, TOP2A, TOPBP1, TRIB1, UNG	320	cellular response to stress
GO:0007076	4.184e-05	0.8221	8 NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NUSAP1, SMC2, SMC4	12	mitotic chromosome condensation
GO:0051325	5.982e-05	5.001	19 BLM, BRCA2, CDC6, CDC7, CDK2, CDKN3, CDT1, CENPF, CHEK1, DBF4, DDX11, GTSE1, INHBA, POLA1, POLD1, POLE, TIMELESS, TIPIN, TPD52L1	73	interphase
GO:0050896	9.574e-05	90.78	134 ADIPOR2, ANG, ANGPTL4, AQP3, BARD1, BBS1, BHLHE40, BLM, BMP2, BMP6, BRCA1, BRCA2, BRIP1, C1R, C1RL, C1S, CBLB, CCL11, CCL2, CCL7, CCNA2, CD55, CENPF, CHAF1A, CHAF1B, CHEK1, CHST2, CTSD, CXCL1, CXCL2, CXCL3, CXCL6, DPP4, DTL, EGR2, EXO1, EXOSC9, F10, F3, FADS1, FANCA, FANCG, FANCI, FCGRT, FEN1, FGF2, FGF7, FOSB, GAA, GCH1, GEM, GPR183, GTSE1, HBEGF, HMGB2, HMOX1, HSD17B2, HSPB3, HTR2A, ICAM1, IFITM1, IL1A, IL1B, IL1RAP, IL1RL1, IL6, IL8, INHBA, ITGA1, JMJD3, LIF, LIG1, LYST, MAFF, MAP2K3, MAP3K4, MCM7, MRE11A, MSH2, MYC, NDRG1, NEIL3, NFIL3, NFKB1, NINJ1, NR3C1, NR4A3, OSMR, P2RX4, PARP2, PDGFA, PLA2G4C, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PPARD, PROS1, PTTG1, RAD51AP1, RAD54B, RAD54L, RAD9A, RECQL4, RELB, RFC2, RFC3, RFC4, RPA3, SECTM1, SGK1, SLC22A18, SOD2, SRF, SUPT16H, TACC3, TACSTD2, THBD, TICAM1, TIMELESS, TIPIN, TNFAIP6, TNFSF4, TNFSF9, TOP2A, TOPBP1, TPST1, TRIB1, TRIM22, UNG, VEGFA, WNT2	1325	response to stimulus
GO:0006297	9.883e-05	1.165	9 LIG1, POLD1, POLD3, POLE, POLE2, RFC2, RFC3, RFC4, RPA3	17	nucleotide-excision repair, DNA gap filling
GO:0031570	1.381e-04	1.85	11 BLM, BRIP1, CCNA2, CDC45L, CDC6, CDT1, CHEK1, GTSE1, MSH2, RAD9A, TIPIN	27	DNA integrity checkpoint
GO:0051716	1.447e-04	23.09	48 BLM, BRCA1, BRCA2, BRIP1, CCNA2, CHAF1A, CHAF1B, CHEK1, CTSD, EXO1, FADS1, FANCA, FANCG, FANCI, FEN1, GTSE1, HMGB2, HMOX1, IL1B, LIG1, MAP3K4, MRE11A, MSH2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51AP1, RAD54B, RAD54L, RAD9A, RECQL4, RFC2, RFC3, RFC4, RPA3, SOD2, SUPT16H, TIPIN, TOP2A, TOPBP1, TRIB1, UNG	337	cellular response to stimulus
GO:0006954	1.707e-04	10.28	28 BMP2, BMP6, C1R, C1RL, C1S, CCL11, CCL2, CCL7, CD55, CHST2, CXCL1, CXCL2, CXCL3, CXCL6, HMOX1, IL1A, IL1B, IL1RAP, IL6, IL8, JMJD3, MAP2K3, NFKB1, OSMR, PLA2G4C, TICAM1, TNFAIP6, TPST1	150	inflammatory response
GO:0016126	2.454e-04	2.329	12 C14orf1, CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, IDI2, LSS, MVD, SC4MOL, SQLE, TM7SF2	34	sterol biosynthetic process
GO:0042127	2.673e-04	25.76	51 ANG, BLM, BMP2, BMPR2, BNC1, BRCA1, BRCA2, CCL2, CDC6, CDC7, CDK2, CDKN3, CHEK1, CXCL1, DDX11, DHCR7, FABP3, FGF1, FGF2, FGF7, GPNMB, HBEGF, HMOX1, HTR2A, IFITM1, IL11, IL1A, IL1B, IL6, IL8, JARID2, LIF, MYC, NAMPT, OSMR, PDGFA, PDGFRB, PTGES, PTHLH, SOD2, SOX4, SOX9, TGFBR1, TIMELESS, TIPIN, TNFSF4, TNS3, TRIB1, TTK, VEGFA, WNT2	376	regulation of cell proliferation
GO:0007093	2.928e-04	1.987	11 BLM, BUB1, BUB1B, CCNA2, CENPF, GTSE1, KNTC1, MAD2L1, TTK, ZWILCH, ZWINT	29	mitotic cell cycle checkpoint
GO:0051320	3.531e-04	1.028	8 BRCA2, CDC7, CDT1, DDX11, POLA1, POLD1, TIMELESS, TIPIN	15	S phase
GO:0006302	4.562e-04	2.466	12 BLM, BRCA1, BRCA2, BRIP1, FEN1, MRE11A, MSH2, POLA1, RAD51AP1, RAD54B, RAD54L, SOD2	36	double-strand break repair
GO:0051329	5.560e-04	4.796	17 BLM, BRCA2, CDC6, CDC7, CDK2, CDKN3, CDT1, CENPF, CHEK1, DBF4, DDX11, GTSE1, INHBA, POLA1, POLD1, POLE, TPD52L1	70	interphase of mitotic cell cycle
GO:0006694	5.666e-04	3.837	15 BMP6, C14orf1, CYP51A1, DHCR7, HMGCR, HMGCS1, HSD17B2, IDI1, IDI2, LSS, MVD, NR3C1, SC4MOL, SQLE, TM7SF2	56	steroid biosynthetic process
GO:0051276	5.759e-04	18.77	40 ASF1B, BLM, BRCA2, CDYL, CENPA, CENPE, CENPF, CHAF1A, CHAF1B, CPA4, DDX11, DLGAP5, ESPL1, EZH2, HIRIP3, HMGB2, JMJD3, JMJD6, MCM2, MRE11A, MSH2, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NR3C1, NUSAP1, PTTG1, RAD54L, RBL1, SMC2, SMC4, SUPT16H, SUV39H1, TOP2A, WHSC1, ZWINT	274	chromosome organization
GO:0016125	6.949e-04	4.385	16 C14orf1, CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, IDI2, INSIG1, LDLR, LSS, MVD, PPARD, SC4MOL, SQLE, SREBF2, TM7SF2	64	sterol metabolic process
GO:0002376	7.200e-04	31.93	58 AQP3, BLM, BMP6, C1R, C1RL, C1S, CBLB, CCL11, CCL2, CCL7, CCNB2, CD55, CXCL1, CXCL2, CXCL3, CXCL6, DNASE2, DPP4, EXO1, EXOSC9, FCGRT, FOXO3, GCH1, GEM, GPR183, HMGB3, HMOX1, ICAM1, IL11, IL1A, IL1B, IL1RAP, IL1RL1, IL6, IL8, INHBA, ITGA1, JARID2, JMJD6, LIF, LIG1, LYST, MSH2, NDRG1, NFIL3, NFKB1, RELB, RUNX1, SECTM1, SOD2, SOX4, TACC3, TGFBR1, TICAM1, TNFSF4, TNFSF9, TRIM22, VEGFA	466	immune system process
GO:0000076	1.271e-03	0.4111	5 CDC45L, CDC6, CDT1, RAD9A, TIPIN	6	DNA replication checkpoint
GO:0032297	1.271e-03	0.4111	5 CDC45L, CDC6, CDT1, RAD9A, TIPIN	6	negative regulation of DNA replication initiation
GO:0006323	1.527e-03	4.179	15 ASF1B, CENPA, CHAF1A, CHAF1B, HMGB2, MCM2, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NUSAP1, SMC2, SMC4, TOP2A	61	DNA packaging
GO:0006695	3.030e-03	1.713	9 CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, IDI2, LSS, MVD, TM7SF2	25	cholesterol biosynthetic process
GO:0008284	3.154e-03	12.81	29 ANG, BLM, BNC1, CCL2, CDC7, CDK2, DDX11, FGF1, FGF2, FGF7, HBEGF, HTR2A, IL11, IL1B, IL6, LIF, MYC, NAMPT, OSMR, PDGFA, PDGFRB, PTHLH, SOX4, TGFBR1, TIPIN, TNFSF4, TNS3, TTK, VEGFA	187	positive regulation of cell proliferation
GO:0016043	3.373e-03	109.4	147 ADIPOR2, ASF1B, ASPM, AURKA, AURKB, BBS1, BIRC5, BLM, BMP2, BRCA1, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC6, CDCA3, CDCA8, CDK2, CDYL, CENPA, CENPE, CENPF, CEP55, CHAF1A, CHAF1B, COL14A1, CP110, CPA4, CTSD, CXCL1, DAAM2, DDX11, DLGAP5, DSN1, ECT2, EGR2, ERCC6L, ESPL1, EXOSC8, EXOSC9, EZH2, FANCA, FANCG, FBXO5, GAA, GCH1, HELLS, HIRIP3, HMGB2, HMOX1, IL1A, IL1B, IL1RAP, IL6, INHBA, JMJD3, JMJD6, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KLF7, KNTC1, LDLR, LRP1, MAD2L1, MARCH2, MCM2, MRE11A, MSH2, MTSS1, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NR3C1, NUSAP1, OIP5, OPTN, PBK, PCNT, PDGFA, PDPN, PKMYT1, PLK1, PLSCR4, POLR2D, PRC1, PRKG1, PSRC1, PTTG1, QPRT, RACGAP1, RAD54L, RBL1, RCL1, RHOQ, RRM1, RRM2, SHMT1, SMC2, SMC4, SOD2, SOX9, SPAG5, SPC25, SRF, STMN1, SUPT16H, SUV39H1, TACC3, TGFBR1, TIMELESS, TIPIN, TMEM48, TNXB, TOM1, TOP2A, TPP1, TPX2, TTF2, TTK, UBE2C, VCL, VEGFA, WEE1, WHSC1, WISP1, WNT2, ZWILCH, ZWINT	1597	cellular component organization
GO:0030174	3.475e-03	0.4796	5 CDC45L, CDC6, CDT1, RAD9A, TIPIN	7	regulation of DNA replication initiation
GO:0051052	3.575e-03	4.522	15 AREG, BLM, BRCA1, BRCA2, CDC45L, CDC6, CDK2, CDT1, GMNN, MRE11A, MSH2, MYC, PDGFA, RAD9A, TIPIN	66	regulation of DNA metabolic process
GO:0048015	4.071e-03	3.083	12 AURKA, BUB1B, FEN1, HMGB2, HTR2A, NDC80, PIK3CD, RFC4, SPAG5, TOP2A, UBE2C, ZWINT	45	phosphoinositide-mediated signaling
GO:0019932	4.242e-03	6.234	18 AURKA, BUB1B, CCL2, FEN1, HMGB2, HTR2A, IL8, NDC80, P2RX4, PIK3CD, PTHLH, RAPGEF2, RCAN2, RFC4, SPAG5, TOP2A, UBE2C, ZWINT	91	second-messenger-mediated signaling
GO:0006275	5.819e-03	2.74	11 AREG, BLM, BRCA2, CDC45L, CDC6, CDK2, CDT1, GMNN, PDGFA, RAD9A, TIPIN	40	regulation of DNA replication
GO:0008156	6.721e-03	1.507	8 BLM, BRCA2, CDC45L, CDC6, CDT1, GMNN, RAD9A, TIPIN	22	negative regulation of DNA replication
GO:0000731	7.348e-03	0.5481	5 POLA1, POLD1, POLD3, POLE, RFC3	8	DNA synthesis during DNA repair
GO:0008203	7.963e-03	3.837	13 CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, IDI2, INSIG1, LDLR, LSS, MVD, PPARD, SREBF2, TM7SF2	56	cholesterol metabolic process
GO:0007088	8.217e-03	2.398	10 DLGAP5, ESPL1, IL1A, IL1B, KIF20B, KNTC1, NEK2, NUSAP1, PKMYT1, UBE2C	35	regulation of mitosis
GO:0010212	8.983e-03	1.576	8 BLM, BRCA2, MSH2, RAD54B, RAD54L, SOD2, THBD, TOPBP1	23	response to ionizing radiation
GO:0051053	8.984e-03	1.987	9 BLM, BRCA2, CDC45L, CDC6, CDT1, GMNN, MSH2, RAD9A, TIPIN	29	negative regulation of DNA metabolic process
GO:0045840	1.076e-02	0.8906	6 DLGAP5, ESPL1, IL1A, IL1B, NUSAP1, UBE2C	13	positive regulation of mitosis
GO:0040011	1.129e-02	15.35	31 ANG, BBS1, CCL11, CCL2, CCL7, CXCL1, CXCL2, CXCL3, CXCL6, FGF2, HBEGF, HMGCR, HMOX1, ICAM1, IL1B, IL6, IL8, ITGA1, LAMA5, PDGFA, PDGFRB, PDPN, PPARD, PRKG1, SRF, TGFBR1, TNS3, TRIB1, VCL, VEGFA, WNT2	224	locomotion
GO:0006955	1.152e-02	19.66	37 BMP6, C1R, C1RL, C1S, CBLB, CCL11, CCL2, CCL7, CD55, CXCL1, CXCL2, CXCL3, CXCL6, EXO1, EXOSC9, FCGRT, GCH1, GEM, GPR183, HMOX1, ICAM1, IL1A, IL1B, IL1RAP, IL1RL1, IL6, IL8, LIF, LYST, MSH2, NFIL3, RELB, SECTM1, TICAM1, TNFSF4, TNFSF9, TRIM22	287	immune response
GO:0000077	1.165e-02	1.644	8 BLM, BRIP1, CCNA2, CHEK1, GTSE1, MSH2, RAD9A, TIPIN	24	DNA damage checkpoint
GO:0006935	1.255e-02	4.59	14 CCL11, CCL2, CCL7, CXCL1, CXCL2, CXCL3, CXCL6, FGF2, IL1B, IL6, IL8, ITGA1, PDGFA, VEGFA	67	chemotaxis
GO:0042330	1.255e-02	4.59	14 CCL11, CCL2, CCL7, CXCL1, CXCL2, CXCL3, CXCL6, FGF2, IL1B, IL6, IL8, ITGA1, PDGFA, VEGFA	67	taxis
GO:0007018	1.417e-02	4.111	13 BBS1, CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A	60	microtubule-based movement
GO:0042770	1.438e-02	3.083	11 BLM, BRCA1, BRCA2, BRIP1, CCNA2, CHEK1, GTSE1, HMOX1, MSH2, RAD9A, TIPIN	45	DNA damage response, signal transduction
GO:0008202	1.439e-02	7.605	19 BMP6, C14orf1, CYP51A1, DHCR7, HMGCR, HMGCS1, HSD17B2, IDI1, IDI2, INSIG1, LDLR, LSS, MVD, NR3C1, PPARD, SC4MOL, SQLE, SREBF2, TM7SF2	111	steroid metabolic process
GO:0030324	1.465e-02	2.603	10 BMPR2, CRISPLD2, DHCR7, FGF1, FGF2, JMJD6, PTHLH, SPRY2, TNS3, WNT2	38	lung development
GO:0009987	1.506e-02	445.4	467 ADAMTS5, ADIPOR2, AEBP1, ALDOC, ANG, ANGPTL2, ANGPTL4, ANK2, ANXA3, AQP3, AREG, ARHGAP11A, ARHGAP19, ARHGAP5, ARID5A, ARL6IP1, ASAP2, ASF1B, ASPM, ATF3, ATP13A3, ATP2A2, AURKA, AURKB, B3GNT2, BARD1, BAT1, BBS1, BCL7A, BHLHE40, BIRC5, BLM, BMP2, BMP6, BMPR2, BNC1, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, C13orf15, C14orf1, C18orf24, C1R, C1RL, C1S, C21orf45, C6orf145, CASP1, CBLB, CCL11, CCL2, CCL7, CCNA2, CCNB1, CCNB2, CCNE2, CCNF, CD55, CDC14B, CDC2, CDC20, CDC25A, CDC45L, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN3, CDT1, CDYL, CENPA, CENPE, CENPF, CENPO, CEP55, CHAF1A, CHAF1B, CHEK1, CHST2, CKAP2, CKS1B, COL14A1, COL15A1, COL21A1, CORIN, CP110, CPA3, CPA4, CREG1, CS, CSGALNACT2, CTSD, CTSF, CTSO, CXCL1, CXCL6, CXCR7, CYP51A1, DAAM2, DACT1, DBF4, DCP1A, DDX11, DDX12, DEK, DEPDC1, DHCR7, DHFR, DKK2, DLGAP5, DMD, DNA2, DNASE2, DPP4, DPT, DRAM, DSCC1, DSN1, DTL, DUSP5, DVL3, E2F8, ECM2, ECT2, EGR2, EGR3, ERCC6L, ESPL1, EXO1, EXOSC8, EXOSC9, EZH2, F10, FABP3, FADS1, FANCA, FANCG, FANCI, FAP, FBXO5, FBXW7, FEM1B, FEN1, FGF1, FGF2, FGF7, FOSB, FOXM1, FOXO3, FRY, FTH1, GAA, GALNAC4S-6ST, GCH1, GDF15, GDPD5, GEM, GFPT2, GINS1, GINS2, GINS3, GINS4, GMNN, GNPTAB, GPNMB, GPR183, GPR37, GRIA1, GRIA3, GRN, GTSE1, H6PD, HBEGF, HELLS, HERC6, HIPK3, HIRIP3, HIVEP1, HIVEP2, HK2, HLX, HMGB2, HMGB3, HMGCR, HMGCS1, HMOX1, HNRNPA2B1, HSD17B2, HTR2A, ICAM1, IDI1, IDI2, IER3, IFITM1, IL11, IL15RA, IL1A, IL1B, IL1RAP, IL1RL1, IL6, IL8, INHBA, INSIG1, ITGA1, ITGB3BP, JARID2, JMJD3, JMJD6, JUND, KHSRP, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KLF7, KLHL21, KNTC1, LAMA5, LBH, LDLR, LIF, LIG1, LIPA, LMCD1, LRP1, LSM2, LSS, LYST, MAD2L1, MAF, MAFF, MAN1C1, MAN2B2, MAP2K3, MAP3K4, MAP3K8, MARCH2, MAX, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MEIS3P1, MELK, MFAP4, MKI67, MLF1IP, MLXIP, MPHOSPH9, MRE11A, MSC, MSH2, MTSS1, MVD, MYBL2, MYC, NAMPT, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NDEL1, NDRG1, NEDD9, NEIL3, NEK2, NFATC1, NFIL3, NFKB1, NINJ1, NR3C1, NR4A1, NR4A2, NR4A3, NUP107, NUP155, NUP93, NUSAP1, OIP5, OMD, OPTN, ORC1L, ORC6L, OSMR, P2RX4, PAPPA, PARP2, PBK, PCNT, PCTK2, PDGFA, PDGFD, PDGFRB, PDPN, PEG10, PGCP, PIGZ, PIK3CD, PKMYT1, PLA2G4C, PLK1, PLK3, PLK4, PLSCR4, PLXNC1, PMEPA1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PPARD, PPL, PPP3CC, PRC1, PRELP, PRIM1, PRKG1, PRPS2, PRSS12, PSMC3IP, PSRC1, PTGDS, PTGES, PTHLH, PTPRE, PTTG1, QPRT, RAB33A, RACGAP1, RAD51AP1, RAD54B, RAD54L, RAD9A, RANGAP1, RAPGEF2, RASGRP1, RASSF8, RBL1, RCAN2, RCL1, RECQL4, REL, RELB, RFC2, RFC3, RFC4, RGPD5, RGS2, RGS3, RHOQ, RMI1, RNASE4, RNASEH2A, RPA3, RPL39L, RPP30, RRAD, RRM1, RRM2, RUNX1, SAP30, SC4MOL, SCD, SECTM1, SERPINF1, SGK1, SHMT1, SKIL, SLC19A2, SLC27A3, SLC2A14, SLC2A3, SMC2, SMC4, SMOX, SOD2, SOX4, SOX9, SPAG5, SPC25, SPRED2, SPRY2, SPRY4, SPSB1, SQLE, SREBF2, SRF, ST3GAL1, STIL, STK38L, STMN1, SUPT16H, SUV39H1, SVEP1, TACC3, TACSTD2, TGFBR1, TICAM1, TIMELESS, TIPIN, TK1, TM7SF2, TMEM48, TNFAIP3, TNFAIP6, TNFAIP8, TNFSF4, TNFSF9, TNS3, TNXB, TOM1, TOP2A, TOPBP1, TP53BP2, TPD52L1, TPP1, TPST1, TPX2, TRAF3, TRAPPC6A, TRIB1, TRIM22, TRIP13, TRMT5, TRPC6, TRPS1, TTF2, TTK, UBA7, UBE2C, UNG, UST, VBP1, VCL, VDR, VEGFA, VRK1, WEE1, WHSC1, WISP1, WNT2, WWTR1, ZNF35, ZNF672, ZNF85, ZWILCH, ZWINT	6501	cellular process
GO:0000724	1.569e-02	0.9591	6 BLM, BRCA1, BRCA2, RAD51AP1, RAD54B, RAD54L	14	double-strand break repair via homologous recombination
GO:0000725	1.569e-02	0.9591	6 BLM, BRCA1, BRCA2, RAD51AP1, RAD54B, RAD54L	14	recombinational repair
GO:0048518	1.789e-02	58.1	84 ANG, ANGPTL4, AQP3, AREG, BARD1, BLM, BMP2, BMP6, BMPR2, BNC1, BRCA1, BRCA2, C1R, C1RL, C1S, CASP1, CCL2, CCNA2, CD55, CDC7, CDK2, DDX11, DLGAP5, DVL3, ECT2, EGR2, ESPL1, FEM1B, FGF1, FGF2, FGF7, FOXO3, HBEGF, HMOX1, HTR2A, ICAM1, IL11, IL1A, IL1B, IL6, IL8, INHBA, JUND, KLF7, LIF, LYST, MAP2K3, MYC, NAMPT, NFKB1, NR4A1, NR4A3, NUSAP1, OSMR, P2RX4, PDGFA, PDGFRB, PDPN, PPARD, PPP3CC, PSRC1, PTHLH, RAD9A, REL, RUNX1, SECTM1, SERPINF1, SOD2, SOX4, SOX9, SRF, TGFBR1, TICAM1, TIPIN, TNFSF4, TNS3, TOP2A, TP53BP2, TRAF3, TTK, UBE2C, VEGFA, WNT2, WWTR1	848	positive regulation of biological process
GO:0006289	1.967e-02	3.22	11 BRCA2, LIG1, NEIL3, POLD1, POLD3, POLE, POLE2, RFC2, RFC3, RFC4, RPA3	47	nucleotide-excision repair
GO:0030323	2.067e-02	2.74	10 BMPR2, CRISPLD2, DHCR7, FGF1, FGF2, JMJD6, PTHLH, SPRY2, TNS3, WNT2	40	respiratory tube development
GO:0006066	2.101e-02	13.22	27 ALDOC, C14orf1, CYP51A1, DHCR7, GAA, GALNAC4S-6ST, GCH1, GDPD5, GFPT2, H6PD, HK2, HMGCR, HMGCS1, IDI1, IDI2, INSIG1, LDLR, LSS, MAN2B2, MVD, MYC, NR3C1, PPARD, SC4MOL, SQLE, SREBF2, TM7SF2	193	cellular alcohol metabolic process
GO:0033261	2.114e-02	0.6851	5 BRCA2, CDC7, CDT1, TIMELESS, TIPIN	10	regulation of S phase
GO:0001649	2.317e-02	1.85	8 BMP2, BMP6, BMPR2, GPNMB, IL6, JUND, PTHLH, WWTR1	27	osteoblast differentiation
GO:0006271	2.326e-02	0.2055	3 POLA1, RFC3, RFC4	3	DNA strand elongation during DNA replication
GO:0048478	2.326e-02	0.2055	3 BLM, BRCA2, TIPIN	3	replication fork protection
GO:0048870	2.403e-02	11.99	25 ANG, BBS1, CCL2, FGF2, HBEGF, HMGCR, HMOX1, ICAM1, IL1B, IL6, IL8, ITGA1, LAMA5, PDGFA, PDGFRB, PDPN, PPARD, PRKG1, SRF, TGFBR1, TNS3, TRIB1, VCL, VEGFA, WNT2	175	cell motility
GO:0016477	3.110e-02	11.58	24 ANG, CCL2, FGF2, HBEGF, HMGCR, HMOX1, ICAM1, IL1B, IL6, IL8, ITGA1, LAMA5, PDGFA, PDGFRB, PDPN, PPARD, PRKG1, SRF, TGFBR1, TNS3, TRIB1, VCL, VEGFA, WNT2	169	cell migration
GO:0006268	3.127e-02	0.7536	5 HMGB2, MCM2, MCM4, MCM6, MCM7	11	DNA unwinding during replication
GO:0042325	3.770e-02	5.275	14 ANG, BARD1, BMP2, FGF2, IL11, IL1B, IL6, INHBA, LIF, MCM7, PDGFD, PDGFRB, TGFBR1, TTK	77	regulation of phosphorylation
GO:0048522	3.801e-02	53.99	77 ANG, AREG, BARD1, BLM, BMP2, BMP6, BMPR2, BNC1, BRCA1, BRCA2, CASP1, CCL2, CCNA2, CDC7, CDK2, DDX11, DLGAP5, DVL3, ECT2, EGR2, ESPL1, FEM1B, FGF1, FGF2, FGF7, FOXO3, HBEGF, HMOX1, HTR2A, ICAM1, IL11, IL1A, IL1B, IL6, INHBA, JUND, KLF7, LIF, LYST, MAP2K3, MYC, NAMPT, NFKB1, NR4A1, NR4A3, NUSAP1, OSMR, P2RX4, PDGFA, PDGFRB, PDPN, PPARD, PPP3CC, PSRC1, PTHLH, RAD9A, REL, RUNX1, SECTM1, SERPINF1, SOD2, SOX4, SOX9, SRF, TGFBR1, TICAM1, TIPIN, TNFSF4, TNS3, TOP2A, TP53BP2, TRAF3, TTK, UBE2C, VEGFA, WNT2, WWTR1	788	positive regulation of cellular process
GO:0006952	3.867e-02	17.61	32 BMP2, BMP6, C1R, C1RL, C1S, CCL11, CCL2, CCL7, CD55, CHST2, CXCL1, CXCL2, CXCL3, CXCL6, GCH1, HMOX1, IL1A, IL1B, IL1RAP, IL1RL1, IL6, IL8, INHBA, JMJD3, LYST, MAP2K3, NFKB1, OSMR, PLA2G4C, TICAM1, TNFAIP6, TPST1	257	defense response
GO:0050900	3.997e-02	2.055	8 CCL2, HMOX1, ICAM1, IL1B, IL6, IL8, ITGA1, VEGFA	30	leukocyte migration
GO:0000084	4.307e-02	0.8221	5 BRCA2, CDT1, DDX11, POLA1, POLD1	12	S phase of mitotic cell cycle
GO:0007052	4.307e-02	0.8221	5 KIF11, KIF23, PRC1, STMN1, TTK	12	mitotic spindle organization
GO:0030705	4.377e-02	4.796	13 BBS1, CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A	70	cytoskeleton-dependent intracellular transport

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005694	2.229e-20	16.76	66 ASF1B, AURKB, BIRC5, BLM, BRCA1, BUB1, BUB1B, C18orf24, C21orf45, CDCA8, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CHEK1, DSN1, ERCC6L, FANCI, HMGB2, HMGB3, HMGN2, ITGB3BP, JUND, KIF22, KIF2C, KNTC1, MAD2L1, MAF, MCM2, MCM3, MCM7, MLF1IP, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NUP107, OIP5, ORC6L, POLA1, POLA2, POLD3, PRIM1, RANGAP1, RFC2, RFC3, RFC4, RPA3, SMC2, SMC4, SPAG5, SPC25, SUPT16H, SUV39H1, TELO2, TIMELESS, TIPIN, TOP2A, TOPBP1, ZWILCH, ZWINT	248	chromosome
GO:0044427	5.720e-20	13.38	58 ASF1B, AURKB, BLM, BUB1, BUB1B, C18orf24, C21orf45, CDCA8, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CHEK1, DSN1, ERCC6L, HMGN2, ITGB3BP, JUND, KIF22, KIF2C, KNTC1, MAD2L1, MAF, MCM2, MCM3, MCM7, MLF1IP, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NUP107, OIP5, ORC6L, POLA1, POLA2, POLD3, PRIM1, RANGAP1, RFC2, RFC3, RFC4, RPA3, SMC2, SMC4, SPAG5, SPC25, SUV39H1, TELO2, TIMELESS, TIPIN, ZWILCH, ZWINT	198	chromosomal part
GO:0000793	8.390e-16	4.46	30 BLM, BRCA1, BUB1, BUB1B, C18orf24, CENPA, CENPE, CENPF, CENPM, CHEK1, DSN1, ERCC6L, HMGB2, KNTC1, MLF1IP, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NUP107, RANGAP1, SMC2, SMC4, SPAG5, SPC25, SUV39H1, TOPBP1, ZWILCH, ZWINT	66	condensed chromosome
GO:0000775	1.903e-15	4.257	29 AURKB, BUB1, BUB1B, C18orf24, C21orf45, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, DSN1, ERCC6L, ITGB3BP, KIF22, KIF2C, KNTC1, MAD2L1, MLF1IP, NDC80, NUP107, OIP5, RANGAP1, SPAG5, SPC25, SUV39H1, ZWILCH, ZWINT	63	chromosome, centromeric region
GO:0000777	9.169e-11	2.297	18 BUB1, BUB1B, C18orf24, CENPA, CENPE, CENPF, CENPM, DSN1, ERCC6L, KNTC1, MLF1IP, NDC80, NUP107, RANGAP1, SPAG5, SPC25, ZWILCH, ZWINT	34	condensed chromosome kinetochore
GO:0000779	9.169e-11	2.297	18 BUB1, BUB1B, C18orf24, CENPA, CENPE, CENPF, CENPM, DSN1, ERCC6L, KNTC1, MLF1IP, NDC80, NUP107, RANGAP1, SPAG5, SPC25, ZWILCH, ZWINT	34	condensed chromosome, centromeric region
GO:0005819	1.205e-10	5.406	27 AURKA, AURKB, BUB1, BUB1B, C18orf24, CDC2, CDC20, CDC6, CENPE, CENPF, DLGAP5, FBXO5, KIF11, KIF14, KIF15, KIF23, KIF4A, KNTC1, MYC, NDEL1, NEDD9, PRC1, PSRC1, RACGAP1, SPAG5, TPX2, TTK	80	spindle
GO:0015630	3.356e-10	21.69	58 AURKA, AURKB, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C18orf24, CCNB1, CCNB2, CDC2, CDC20, CDC45L, CDC6, CENPE, CENPF, CEP152, CEP97, CKAP2, CP110, DLGAP5, ESPL1, FBXO5, GABARAPL1, GABARAPL3, GTSE1, IL1RL1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LYST, MYC, NDEL1, NEDD9, NEK2, NUSAP1, PCNT, PLK1, PRC1, PSRC1, RACGAP1, SPAG5, SPRY2, STMN1, TNFAIP3, TOM1, TOP2A, TPX2, TTK	321	microtubule cytoskeleton
GO:0000776	4.730e-10	3.108	20 BUB1, BUB1B, C18orf24, CENPA, CENPE, CENPF, CENPM, DSN1, ERCC6L, KIF22, KNTC1, MAD2L1, MLF1IP, NDC80, NUP107, RANGAP1, SPAG5, SPC25, ZWILCH, ZWINT	46	kinetochore
GO:0043228	1.764e-08	90.48	147 ALDOC, ANGPTL4, ANK2, ARID5A, ASF1B, ATF3, AURKA, AURKB, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C18orf24, C21orf45, CASP1, CCNB1, CCNB2, CDC2, CDC20, CDC45L, CDC6, CDCA8, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CEP152, CEP97, CHEK1, CKAP2, CP110, CTSO, DDX11, DLGAP5, DMD, DSN1, ERCC6L, ESPL1, EXOSC9, FANCI, FBXO5, GABARAPL1, GABARAPL3, GTSE1, HLX, HMGB2, HMGB3, HMGN2, HMOX1, IL1RL1, ITGB3BP, JUND, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LMNB1, LMNB2, LYST, MAD2L1, MAF, MCM2, MCM3, MCM4, MCM7, MKI67, MLF1IP, MRE11A, MTSS1, MYBL1, MYC, MYO1D, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NDEL1, NDRG1, NEDD9, NEK2, NR3C1, NUP107, NUSAP1, OIP5, ORC6L, PARP2, PCNT, PLK1, POLA1, POLA2, POLD3, PPL, PRC1, PRIM1, PRKG1, PSRC1, RACGAP1, RAD9A, RANGAP1, RFC2, RFC3, RFC4, RPA3, RPL39L, RPP30, SMC2, SMC4, SOX9, SPAG5, SPC25, SPRY2, SRF, STMN1, SUPT16H, SUV39H1, TELO2, TIMELESS, TIPIN, TNFAIP3, TNS3, TOM1, TOP2A, TOPBP1, TPX2, TRMT5, TTK, VCL, WDHD1, WWTR1, ZWILCH, ZWINT	1339	non-membrane-bounded organelle
GO:0043232	1.764e-08	90.48	147 ALDOC, ANGPTL4, ANK2, ARID5A, ASF1B, ATF3, AURKA, AURKB, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C18orf24, C21orf45, CASP1, CCNB1, CCNB2, CDC2, CDC20, CDC45L, CDC6, CDCA8, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CEP152, CEP97, CHEK1, CKAP2, CP110, CTSO, DDX11, DLGAP5, DMD, DSN1, ERCC6L, ESPL1, EXOSC9, FANCI, FBXO5, GABARAPL1, GABARAPL3, GTSE1, HLX, HMGB2, HMGB3, HMGN2, HMOX1, IL1RL1, ITGB3BP, JUND, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LMNB1, LMNB2, LYST, MAD2L1, MAF, MCM2, MCM3, MCM4, MCM7, MKI67, MLF1IP, MRE11A, MTSS1, MYBL1, MYC, MYO1D, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NDEL1, NDRG1, NEDD9, NEK2, NR3C1, NUP107, NUSAP1, OIP5, ORC6L, PARP2, PCNT, PLK1, POLA1, POLA2, POLD3, PPL, PRC1, PRIM1, PRKG1, PSRC1, RACGAP1, RAD9A, RANGAP1, RFC2, RFC3, RFC4, RPA3, RPL39L, RPP30, SMC2, SMC4, SOX9, SPAG5, SPC25, SPRY2, SRF, STMN1, SUPT16H, SUV39H1, TELO2, TIMELESS, TIPIN, TNFAIP3, TNS3, TOM1, TOP2A, TOPBP1, TPX2, TRMT5, TTK, VCL, WDHD1, WWTR1, ZWILCH, ZWINT	1339	intracellular non-membrane-bounded organelle
GO:0005657	2.612e-07	1.757	13 BLM, CDT1, CHEK1, MCM3, MCM7, POLA1, POLA2, POLD3, PRIM1, RFC2, RFC3, RFC4, RPA3	26	replication fork
GO:0044430	2.676e-06	28.24	59 AURKA, AURKB, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C18orf24, CCNB1, CDC2, CDC20, CDC45L, CDC6, CENPE, CENPF, CEP152, CEP97, CKAP2, CP110, DLGAP5, ESPL1, FBXO5, GABARAPL1, GABARAPL3, GTSE1, IL1RL1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LMNB1, LMNB2, MYC, MYO1D, NDEL1, NEDD9, NEK2, NUSAP1, PCNT, PLK1, PRC1, PSRC1, RACGAP1, SPAG5, SPRY2, STMN1, TNFAIP3, TOM1, TOP2A, TPX2, TTK	418	cytoskeletal part
GO:0005634	3.367e-06	206.7	266 ADAMTS5, AEBP1, ANG, ANGPTL4, ARHGAP19, ARID5A, ASF1B, ASPM, ATF3, AURKA, AURKB, BARD1, BAT1, BHLHE40, BIRC5, BLM, BNC1, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, C12orf48, C13orf15, C21orf45, CASP1, CBLB, CCNA2, CCNB1, CCNB2, CCNE2, CCNF, CCNJ, CDC14B, CDC2, CDC20, CDC25A, CDC45L, CDC6, CDC7, CDCA4, CDCA8, CDK2, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CHAF1A, CHAF1B, CHEK1, CKS1B, CPA3, DACT1, DBF4, DCN, DCP1A, DDX11, DDX12, DEK, DEPDC1, DHCR7, DLGAP5, DMD, DNA2, DSCC1, DSN1, DTL, DUSP5, E2F8, EGR2, EGR3, ESPL1, EXO1, EXOSC8, EXOSC9, EZH2, FANCA, FANCG, FANCI, FBXO5, FBXW7, FEN1, FOSB, FOXM1, FOXO3, GCH1, GINS1, GINS2, GINS3, GINS4, GMNN, GNPTAB, HELLS, HIPK3, HIRIP3, HIVEP1, HJURP, HLX, HMGB1L10, HMGB2, HMGB3, HMGB3L1, HMOX1, HNRNPA2B1, IL15RA, ITGB3BP, ITPKC, JARID2, JMJD3, JMJD6, JUND, KHSRP, KIAA0586, KIF11, KIF14, KIF18A, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KLF7, KNTC1, LBH, LIG1, LMCD1, LMNB1, LMNB2, LRP1, LSM2, MAD2L1, MAF, MAFF, MAX, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM1, MEIS3P1, MKI67, MLF1IP, MLXIP, MRE11A, MSC, MSH2, MYBL1, MYBL2, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NDRG1, NEDD9, NEIL3, NEK2, NFATC1, NFIL3, NFKB1, NR3C1, NR4A1, NR4A2, NR4A3, NUP107, NUP155, NUP93, NUSAP1, OIP5, ORC1L, ORC6L, PARP2, PEG10, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PPARD, PPL, PRC1, PRIM1, PRKG1, PROS1, PSMC3IP, PTGDS, PTGES, PTHLH, PTTG1, RACGAP1, RAD51AP1, RAD54B, RAD54L, RAD9A, RANGAP1, RBL1, RCL1, RECQL4, REL, RELB, RFC2, RFC3, RFC4, RGS3, RMI1, RNASEH2A, RPA3, RPP30, RUNX1, SAP30, SGK1, SKIL, SMC2, SMC4, SOX4, SOX9, SPC25, SREBF2, SRF, SUPT16H, SUV39H1, TELO2, TIMELESS, TIPIN, TMEM48, TNFAIP3, TNS3, TOP2A, TOPBP1, TP53BP2, TPRKB, TPX2, TRIB1, TRIM22, TRIP13, TRMT5, TRPS1, TTF2, UBE2C, UNG, VBP1, VDR, VRK1, WDHD1, WEE1, WHSC1, WWTR1, ZNF35, ZNF672, ZNF85, ZWINT	3059	nucleus
GO:0000796	7.363e-06	0.4054	6 NCAPD2, NCAPD3, NCAPG, NCAPH, SMC2, SMC4	6	condensin complex
GO:0000228	8.448e-06	5.203	20 BLM, BUB1, CHEK1, HMGB2, MCM2, MCM3, MCM7, NCAPD2, NCAPD3, ORC6L, POLA1, POLA2, POLD3, PRIM1, RPA3, SMC2, SUV39H1, TIMELESS, TIPIN, TOPBP1	77	nuclear chromosome
GO:0005576	8.628e-06	45.48	81 ADAMTS5, AEBP1, ANG, ANGPTL2, ANGPTL4, AREG, ASPN, BMP2, BMP6, C1orf56, C1R, C1RL, C1S, CCL11, CCL2, CCL7, CLEC3B, COL14A1, COL15A1, COL21A1, CPA4, CREG1, CRISPLD2, CTSD, CXCL1, CXCL2, CXCL3, CXCL6, DCN, DKK2, DPP4, DPT, ECM2, F10, FGF1, FGF2, FGF7, GDF15, GRN, HBEGF, HMOX1, ICAM1, IL11, IL15RA, IL1A, IL1B, IL1RAP, IL1RL1, IL6, IL8, INHBA, LAMA5, LIF, MAN2B2, MFAP4, MXRA5, OLFML1, OLFML2A, OMD, PAPPA, PDGFA, PDGFD, PDGFRL, PGCP, PRELP, PROS1, PRSS12, PTGDS, PTHLH, RNASE4, SECTM1, SERPINF1, ST3GAL1, SVEP1, THBD, TNFSF4, TNFSF9, TNXB, VEGFA, WISP1, WNT2	673	extracellular region
GO:0044421	1.303e-05	25.41	53 ADAMTS5, ANG, ANGPTL2, ANGPTL4, AREG, ASPN, BMP2, BMP6, C1RL, CCL11, CCL2, CCL7, COL14A1, COL15A1, COL21A1, CXCL1, CXCL2, CXCL3, CXCL6, DCN, DKK2, DPT, ECM2, FGF1, FGF2, GDF15, GRN, HBEGF, HMOX1, ICAM1, IL11, IL1A, IL1B, IL6, IL8, INHBA, LAMA5, LIF, MFAP4, OLFML2A, OMD, PDGFA, PGCP, PRELP, PTHLH, SECTM1, SERPINF1, THBD, TNFSF4, TNFSF9, TNXB, VEGFA, WNT2	376	extracellular region part
GO:0005615	2.970e-05	16.01	38 ANG, ANGPTL2, ANGPTL4, AREG, BMP2, BMP6, C1RL, CCL11, CCL2, CCL7, CXCL1, CXCL2, CXCL3, CXCL6, DKK2, FGF1, FGF2, GDF15, GRN, HBEGF, HMOX1, ICAM1, IL11, IL1A, IL1B, IL6, IL8, INHBA, LIF, PDGFA, PGCP, PTHLH, SECTM1, SERPINF1, THBD, TNFSF4, TNFSF9, VEGFA	237	extracellular space
GO:0005654	4.360e-05	38.18	69 BLM, BRCA1, BRCA2, CCNA2, CCNB1, CCNE2, CDC2, CDC20, CDC25A, CDC45L, CDC6, CDC7, CDK2, CDT1, CHAF1A, CHAF1B, CHEK1, CKS1B, DBF4, DNA2, E2F8, EZH2, FBXO5, GMNN, KIF20A, KIF20B, KIF23, LIG1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MRE11A, MYC, NFKB1, NR4A1, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRIM1, RBL1, RFC2, RFC3, RFC4, RPA3, SAP30, SUPT16H, SUV39H1, TOP2A, TOPBP1, TTF2, UBE2C, WDHD1, WEE1, WWTR1	565	nucleoplasm
GO:0043596	1.000e-04	0.7433	7 MCM3, MCM7, POLA1, POLA2, POLD3, PRIM1, RPA3	11	nuclear replication fork
GO:0044428	1.430e-04	76.02	114 ANGPTL4, ARID5A, ATF3, BARD1, BAT1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, CASP1, CCNA2, CCNB1, CCNE2, CDC2, CDC20, CDC25A, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CKS1B, DBF4, DDX11, DHCR7, DNA2, DTL, E2F8, EXOSC9, EZH2, FBXO5, GMNN, HLX, HMGB2, HMOX1, HNRNPA2B1, IL15RA, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, LSM2, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MKI67, MRE11A, MSH2, MYBL1, MYC, NCAPD2, NCAPD3, NFKB1, NR3C1, NR4A1, NUP107, NUP155, NUP93, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRIM1, PRKG1, PTGDS, PTGES, RAD9A, RANGAP1, RBL1, RFC2, RFC3, RFC4, RPA3, RPP30, SAP30, SMC2, SOX9, SRF, SUPT16H, SUV39H1, TIMELESS, TIPIN, TMEM48, TNS3, TOP2A, TOPBP1, TRMT5, TTF2, UBE2C, WDHD1, WEE1, WWTR1	1125	nuclear part
GO:0031981	1.632e-04	57.98	92 ANGPTL4, ARID5A, ATF3, BIRC5, BLM, BRCA1, BRCA2, CASP1, CCNA2, CCNB1, CCNE2, CDC2, CDC20, CDC25A, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CKS1B, DBF4, DDX11, DNA2, E2F8, EXOSC9, EZH2, FBXO5, GMNN, HLX, HMGB2, HMOX1, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MKI67, MRE11A, MYBL1, MYC, NFKB1, NR3C1, NR4A1, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRIM1, PRKG1, RAD9A, RBL1, RFC2, RFC3, RFC4, RPA3, RPP30, SAP30, SOX9, SRF, SUPT16H, SUV39H1, TNS3, TOP2A, TOPBP1, TRMT5, TTF2, UBE2C, WDHD1, WEE1, WWTR1	858	nuclear lumen
GO:0030894	3.488e-04	0.6081	6 MCM3, POLA1, POLA2, POLD3, PRIM1, RPA3	9	replisome
GO:0043601	3.488e-04	0.6081	6 MCM3, POLA1, POLA2, POLD3, PRIM1, RPA3	9	nuclear replisome
GO:0005874	7.152e-04	9.933	25 CDC2, CENPE, CKAP2, GABARAPL1, GABARAPL3, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, NDEL1, NUSAP1, PRC1, RACGAP1, SPAG5, SPRY2, STMN1	147	microtubule
GO:0044454	8.505e-04	3.852	14 BLM, BUB1, MCM2, MCM3, MCM7, NCAPD3, ORC6L, POLA1, POLA2, POLD3, PRIM1, RPA3, TIMELESS, TIPIN	57	nuclear chromosome part
GO:0044446	2.016e-03	180.9	223 ABCA5, ANGPTL4, ARID5A, ARL6IP1, ASF1B, ATF3, ATP2A2, AURKA, AURKB, B3GNT2, BARD1, BAT1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C14orf1, C18orf24, C21orf45, C4orf18, CASP1, CCNA2, CCNB1, CCNE2, CDC2, CDC20, CDC25A, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CEP152, CEP97, CHAF1A, CHAF1B, CHEK1, CHIC2, CHST2, CKAP2, CKS1B, CP110, CS, CSGALNACT2, CYP51A1, DBF4, DDX11, DHCR7, DLGAP5, DNA2, DRAM, DSN1, DTL, E2F8, ENTPD7, ERCC6L, ESPL1, EXOSC9, EZH2, FADS1, FBXO5, GABARAPL1, GABARAPL3, GALNAC4S-6ST, GMNN, GPR37, GRIA1, GTSE1, H6PD, HK2, HLX, HMGB2, HMGCR, HMGN2, HMOX1, HNRNPA2B1, HSD17B2, IL15RA, IL1RL1, INSIG1, ITGB3BP, JUND, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LDLR, LIG1, LMNB1, LMNB2, LSM2, MAD2L1, MAF, MAN1A1, MAN1C1, MARCH2, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MKI67, MLF1IP, MLXIP, MPHOSPH9, MRE11A, MSH2, MYBL1, MYC, MYO1D, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NDEL1, NEDD9, NEK2, NFKB1, NR3C1, NR4A1, NUP107, NUP155, NUP93, NUSAP1, OIP5, ORC1L, ORC6L, PARP2, PCNT, PDGFA, PIGZ, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRC1, PRIM1, PRKG1, PSRC1, PTGDS, PTGES, RACGAP1, RAD9A, RANGAP1, RASGRP1, RBL1, RFC2, RFC3, RFC4, RPA3, RPL39L, RPP30, RTN2, SAP30, SC4MOL, SCD, SLC27A3, SMC2, SMC4, SOD2, SOX9, SPAG5, SPC25, SPRY2, SQLE, SREBF2, SRF, ST3GAL1, STMN1, SUPT16H, SUV39H1, TELO2, TIMELESS, TIPIN, TM7SF2, TMEM48, TNFAIP3, TNS3, TOM1, TOP2A, TOPBP1, TPST1, TPX2, TRMT5, TTF2, TTK, UBE2C, UST, VEGFA, WDHD1, WEE1, WNT2, WWTR1, ZWILCH, ZWINT	2677	intracellular organelle part
GO:0044422	2.557e-03	181.6	223 ABCA5, ANGPTL4, ARID5A, ARL6IP1, ASF1B, ATF3, ATP2A2, AURKA, AURKB, B3GNT2, BARD1, BAT1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C14orf1, C18orf24, C21orf45, C4orf18, CASP1, CCNA2, CCNB1, CCNE2, CDC2, CDC20, CDC25A, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CEP152, CEP97, CHAF1A, CHAF1B, CHEK1, CHIC2, CHST2, CKAP2, CKS1B, CP110, CS, CSGALNACT2, CYP51A1, DBF4, DDX11, DHCR7, DLGAP5, DNA2, DRAM, DSN1, DTL, E2F8, ENTPD7, ERCC6L, ESPL1, EXOSC9, EZH2, FADS1, FBXO5, GABARAPL1, GABARAPL3, GALNAC4S-6ST, GMNN, GPR37, GRIA1, GTSE1, H6PD, HK2, HLX, HMGB2, HMGCR, HMGN2, HMOX1, HNRNPA2B1, HSD17B2, IL15RA, IL1RL1, INSIG1, ITGB3BP, JUND, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LDLR, LIG1, LMNB1, LMNB2, LSM2, MAD2L1, MAF, MAN1A1, MAN1C1, MARCH2, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MKI67, MLF1IP, MLXIP, MPHOSPH9, MRE11A, MSH2, MYBL1, MYC, MYO1D, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NDEL1, NEDD9, NEK2, NFKB1, NR3C1, NR4A1, NUP107, NUP155, NUP93, NUSAP1, OIP5, ORC1L, ORC6L, PARP2, PCNT, PDGFA, PIGZ, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRC1, PRIM1, PRKG1, PSRC1, PTGDS, PTGES, RACGAP1, RAD9A, RANGAP1, RASGRP1, RBL1, RFC2, RFC3, RFC4, RPA3, RPL39L, RPP30, RTN2, SAP30, SC4MOL, SCD, SLC27A3, SMC2, SMC4, SOD2, SOX9, SPAG5, SPC25, SPRY2, SQLE, SREBF2, SRF, ST3GAL1, STMN1, SUPT16H, SUV39H1, TELO2, TIMELESS, TIPIN, TM7SF2, TMEM48, TNFAIP3, TNS3, TOM1, TOP2A, TOPBP1, TPST1, TPX2, TRMT5, TTF2, TTK, UBE2C, UST, VEGFA, WDHD1, WEE1, WNT2, WWTR1, ZWILCH, ZWINT	2687	organelle part
GO:0005658	3.713e-03	0.3379	4 MCM3, POLA1, POLA2, PRIM1	5	alpha DNA polymerase:primase complex
GO:0000940	9.926e-03	0.2027	3 BUB1B, CENPE, CENPF	3	outer kinetochore of condensed chromosome
GO:0005856	1.006e-02	46.76	70 ALDOC, ANK2, AURKA, AURKB, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C18orf24, CCNB1, CCNB2, CDC2, CDC20, CDC45L, CDC6, CENPE, CENPF, CEP152, CEP97, CKAP2, CP110, CTSO, DLGAP5, DMD, ESPL1, FBXO5, GABARAPL1, GABARAPL3, GTSE1, IL1RL1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LMNB1, LMNB2, LYST, MTSS1, MYC, MYO1D, NCAPH, NDEL1, NDRG1, NEDD9, NEK2, NUSAP1, PCNT, PLK1, PPL, PRC1, PSRC1, RACGAP1, SPAG5, SPRY2, STMN1, TNFAIP3, TOM1, TOP2A, TPX2, TTK, VCL	692	cytoskeleton
GO:0005815	2.132e-02	10.54	22 AURKA, BRCA1, BRCA2, BUB1, C13orf15, CCNB1, CDC45L, CEP152, CEP97, CP110, DLGAP5, ESPL1, IL1RL1, KIF15, KIF20B, NDEL1, NEK2, PCNT, PLK1, TNFAIP3, TOM1, TOP2A	156	microtubule organizing center
GO:0005876	2.355e-02	1.216	6 CDC2, KIF11, KIF4A, KNTC1, PRC1, SPAG5	18	spindle microtubule
GO:0043233	2.723e-02	72.17	97 ANGPTL4, ARID5A, ATF3, BIRC5, BLM, BRCA1, BRCA2, CASP1, CCNA2, CCNB1, CCNE2, CDC2, CDC20, CDC25A, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CKS1B, CS, DBF4, DDX11, DNA2, E2F8, EXOSC9, EZH2, FBXO5, GMNN, H6PD, HLX, HMGB2, HMOX1, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MKI67, MRE11A, MYBL1, MYC, NFKB1, NR3C1, NR4A1, OIP5, ORC1L, ORC6L, PARP2, PDGFA, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRIM1, PRKG1, RAD9A, RBL1, RFC2, RFC3, RFC4, RPA3, RPP30, SAP30, SOD2, SOX9, SRF, SUPT16H, SUV39H1, TNS3, TOP2A, TOPBP1, TRMT5, TTF2, UBE2C, VEGFA, WDHD1, WEE1, WWTR1	1068	organelle lumen
GO:0005875	3.416e-02	4.46	12 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A	66	microtubule associated complex
GO:0070013	3.493e-02	71.08	95 ANGPTL4, ARID5A, ATF3, BIRC5, BLM, BRCA1, BRCA2, CASP1, CCNA2, CCNB1, CCNE2, CDC2, CDC20, CDC25A, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CKS1B, CS, DBF4, DDX11, DNA2, E2F8, EXOSC9, EZH2, FBXO5, GMNN, H6PD, HLX, HMGB2, HMOX1, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MKI67, MRE11A, MYBL1, MYC, NFKB1, NR3C1, NR4A1, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRIM1, PRKG1, RAD9A, RBL1, RFC2, RFC3, RFC4, RPA3, RPP30, SAP30, SOD2, SOX9, SRF, SUPT16H, SUV39H1, TNS3, TOP2A, TOPBP1, TRMT5, TTF2, UBE2C, WDHD1, WEE1, WWTR1	1052	intracellular organelle lumen
GO:0031974	3.641e-02	73.86	98 ANGPTL4, ARID5A, ATF3, BIRC5, BLM, BRCA1, BRCA2, CASP1, CCNA2, CCNB1, CCNE2, CDC2, CDC20, CDC25A, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CKS1B, CS, DBF4, DDX11, DNA2, E2F8, EXOSC9, EZH2, FBXO5, GMNN, H6PD, HLX, HMGB2, HMOX1, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MKI67, MRE11A, MYBL1, MYC, NFKB1, NR3C1, NR4A1, OIP5, ORC1L, ORC6L, PARP2, PDGFA, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRIM1, PRKG1, PTGES, RAD9A, RBL1, RFC2, RFC3, RFC4, RPA3, RPP30, SAP30, SOD2, SOX9, SRF, SUPT16H, SUV39H1, TNS3, TOP2A, TOPBP1, TRMT5, TTF2, UBE2C, VEGFA, WDHD1, WEE1, WWTR1	1093	membrane-enclosed lumen
GO:0000794	3.844e-02	1.351	6 BLM, BUB1, CHEK1, NCAPD3, SUV39H1, TOPBP1	20	condensed nuclear chromosome
GO:0000922	3.844e-02	1.351	6 BUB1, CENPF, DLGAP5, KIF11, KNTC1, TPX2	20	spindle pole
GO:0000785	4.906e-02	5.946	14 ASF1B, CDYL, CENPA, CENPF, HMGN2, JUND, MAF, MCM2, MCM7, OIP5, POLA1, SUV39H1, TIMELESS, TIPIN	88	chromatin

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005125	1.688e-07	4.646	23 AREG, BMP2, BMP6, CCL11, CCL2, CCL7, CXCL1, CXCL2, CXCL6, GDF15, GRN, IL11, IL1A, IL1B, IL6, IL8, INHBA, LIF, NAMPT, SECTM1, TNFSF4, TNFSF9, VEGFA	71	cytokine activity
GO:0003777	6.509e-04	2.421	12 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A	37	microtubule motor activity
GO:0003677	8.348e-04	78.19	116 AEBP1, ANG, ARID5A, ATF3, BHLHE40, BLM, BNC1, BRCA1, BRCA2, BRIP1, C12orf48, CENPA, DDX11, DDX12, DEK, DNA2, DNASE2, DSCC1, E2F8, EGR2, EGR3, ERCC6L, EXO1, EZH2, FANCG, FEN1, FOSB, FOXM1, FOXO3, HELLS, HIVEP1, HIVEP2, HJURP, HLX, HMGB1L10, HMGB2, HMGB3, HMGB3L1, HNRNPA2B1, JARID2, JMJD3, JUND, KHSRP, KIF15, KIF22, KIF2C, KIF4A, KLF7, LHFP, LIG1, MAF, MAFF, MAX, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MEIS3P1, MLXIP, MRE11A, MSC, MSH2, MYBL1, MYBL2, MYC, NEIL3, NFATC1, NFIL3, NFKB1, NR3C1, NR4A1, NR4A2, NR4A3, NUSAP1, ORC1L, ORC6L, PARP2, PEG10, POLA1, POLA2, POLD1, POLE, POLE2, POLQ, PPARD, PSMC3IP, PTTG1, RAD51AP1, RAD54B, RAD54L, REL, RELB, RFC2, RFC3, RFC4, RPA3, RUNX1, SOX4, SOX9, SREBF2, SRF, THAP10, TNFAIP3, TOP2A, TOPBP1, TRIM22, TRPS1, TTF2, VDR, WDHD1, WHSC1, ZNF35, ZNF672, ZNF85	1195	DNA binding
GO:0008083	1.225e-03	5.954	19 AREG, BMP2, BMP6, CXCL1, FGF1, FGF2, FGF7, GDF15, GRN, HBEGF, IL11, IL1A, IL1B, IL6, INHBA, LIF, PDGFA, PDGFD, VEGFA	91	growth factor activity
GO:0005524	2.079e-03	52.41	83 ABCA5, ATP13A3, ATP2A2, AURKA, AURKB, BAT1, BLM, BMPR2, BRIP1, BUB1, BUB1B, CDC2, CDC6, CDC7, CDK2, CENPE, CHEK1, DDX11, DDX12, DNA2, ERCC6L, HELLS, HK2, HSPA12A, ITPKC, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MAP2K3, MAP3K4, MAP3K8, MCM2, MCM3, MCM5, MCM6, MCM7, MELK, MKI67, MSH2, MVD, MYO1D, NEK2, ORC1L, P2RX4, PCTK2, PDGFRB, PKMYT1, PLK1, PLK3, PLK4, POLQ, PRKG1, RAD54B, RAD54L, RECQL4, RFC2, RFC4, RRM1, SGK1, SMC2, SMC4, STK38L, TGFBR1, TK1, TOP2A, TPX2, TRIB1, TRIP13, TTF2, TTK, UBA7, UBE2C, VRK1, WEE1	801	ATP binding
GO:0005515	2.130e-03	294.8	340 ADAMTS5, ADIPOR2, ALDOC, ANG, ANGPTL2, ANGPTL4, ANK2, ANP32E, AREG, ARHGAP5, ARL6IP1, ASAP2, ASF1B, ASPM, ASPN, ATF3, ATP2A2, AURKA, AURKB, BARD1, BAT1, BBS1, BHLHE40, BIRC5, BLM, BMP2, BMP6, BMPR2, BRCA1, BRCA2, BRIP1, BUB1B, C13orf15, C6orf145, CASP1, CBLB, CCL11, CCL2, CCL7, CCNA2, CCNB1, CCNB2, CCNE2, CCNF, CDC14B, CDC2, CDC20, CDC25A, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDKN3, CDT1, CENPA, CENPE, CENPF, CENPO, CEP97, CHAF1A, CHAF1B, CHEK1, CHMP1B, CKS1B, CLEC3B, COL14A1, COL15A1, CP110, CREG1, CSGALNACT2, CXCL1, CXCL2, CXCL6, CXCR7, DAAM2, DBF4, DCN, DCP1A, DEK, DHCR7, DLGAP5, DMD, DNAJC9, DNASE2, DOCK9, DPP4, DPT, DSN1, DTL, DVL3, ECM2, ECT2, EGR2, ERCC6L, ESPL1, EXO1, EXOSC8, EXOSC9, EZH2, F10, FADS1, FANCA, FANCG, FANCI, FAP, FBXO5, FBXW7, FCGRT, FEM1B, FEN1, FGF1, FGF2, FGF7, FOSB, FOXM1, FOXO3, FTH1, GABARAPL1, GCH1, GDF15, GEM, GINS1, GINS2, GINS4, GMNN, GNPTAB, GPNMB, GRIA1, GRN, HBEGF, HIVEP1, HMGB2, HMGN2, HMOX1, HNRNPA2B1, HTR2A, ICAM1, IER3, IFITM1, IL11, IL15RA, IL1A, IL1B, IL1RAP, IL1RL1, IL6, IL8, INHBA, INSIG1, ITGA1, ITGB3BP, ITPKC, JARID2, JHDM1D, JMJD6, JUND, KCND3, KHSRP, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KLF7, KLHL21, KNTC1, LAMA5, LDLR, LIF, LMCD1, LRIG1, LRP1, LRRC32, LSM2, LYST, MAD2L1, MAGI2, MAP2K3, MAP3K8, MAX, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MELK, MFAP4, MKI67, MLF1IP, MRE11A, MSC, MSH2, MTSS1, MXRA5, MYC, MYO1D, NAMPT, NASP, NCAPD2, NCAPG, NDC80, NDEL1, NDRG1, NEDD9, NEK2, NFIL3, NFKB1, NINJ1, NR3C1, NR4A1, NUP107, NUP93, OIP5, OLFML2A, OMD, OPTN, ORC1L, ORC6L, OSMR, P2RX4, PARP2, PBK, PCNT, PDGFA, PDGFD, PDGFRB, PGRMC2, PIK3CD, PKMYT1, PLK1, PLK3, PLK4, PLSCR4, PLXNC1, PMEPA1, POLA1, POLA2, POLD1, POLD3, POLE, PPARD, PPL, PPP3CC, PRC1, PRELP, PRIM1, PRKG1, PSMC3IP, PSRC1, PTHLH, PTTG1, QPRT, RACGAP1, RAD51AP1, RAD54B, RAD9A, RANGAP1, RAPGEF2, RASGRP1, RBL1, REL, RELB, RFC2, RFC3, RFC4, RFWD3, RGS2, RGS3, RHOQ, RNF103, RPP30, RPRD2, RRAD, RRM1, RRM2, RUNX1, SAP30, SECTM1, SGK1, SHCBP1, SHMT1, SKIL, SMC2, SMC4, SOD2, SOX4, SOX9, SPC25, SPRY2, SPRY4, SREBF2, SRF, STK38L, STMN1, SUV39H1, SVEP1, TACC3, TELO2, TGFBR1, THBD, TICAM1, TIPIN, TNFAIP3, TNFAIP6, TNFAIP8, TNFSF4, TNFSF9, TNS3, TOM1, TOP2A, TOPBP1, TP53BP2, TPD52L1, TPP1, TPRKB, TPX2, TRAF3, TRIB1, TRIM22, TRIP13, TRPC6, TRPS1, TTK, UNG, VBP1, VCL, VDR, VEGFA, VRK1, WEE1, WHSC1, WISP1, WNT2, WWTR1, ZNF85, ZWILCH, ZWINT	4505	protein binding
GO:0008009	2.337e-03	0.9161	7 CCL11, CCL2, CCL7, CXCL1, CXCL2, CXCL6, IL8	14	chemokine activity
GO:0042379	2.337e-03	0.9161	7 CCL11, CCL2, CCL7, CXCL1, CXCL2, CXCL6, IL8	14	chemokine receptor binding
GO:0032559	2.887e-03	53	83 ABCA5, ATP13A3, ATP2A2, AURKA, AURKB, BAT1, BLM, BMPR2, BRIP1, BUB1, BUB1B, CDC2, CDC6, CDC7, CDK2, CENPE, CHEK1, DDX11, DDX12, DNA2, ERCC6L, HELLS, HK2, HSPA12A, ITPKC, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MAP2K3, MAP3K4, MAP3K8, MCM2, MCM3, MCM5, MCM6, MCM7, MELK, MKI67, MSH2, MVD, MYO1D, NEK2, ORC1L, P2RX4, PCTK2, PDGFRB, PKMYT1, PLK1, PLK3, PLK4, POLQ, PRKG1, RAD54B, RAD54L, RECQL4, RFC2, RFC4, RRM1, SGK1, SMC2, SMC4, STK38L, TGFBR1, TK1, TOP2A, TPX2, TRIB1, TRIP13, TTF2, TTK, UBA7, UBE2C, VRK1, WEE1	810	adenyl ribonucleotide binding
GO:0008094	3.691e-03	2.486	11 BLM, BRIP1, DDX11, DDX12, DNA2, RAD54B, RFC2, RFC3, RFC4, TOP2A, TTF2	38	DNA-dependent ATPase activity
GO:0003678	5.127e-03	2.159	10 BLM, BRIP1, DDX11, DDX12, DNA2, MCM4, MCM6, MCM7, RAD54B, RECQL4	33	DNA helicase activity
GO:0030554	5.831e-03	55.95	85 ABCA5, ATP13A3, ATP2A2, AURKA, AURKB, BAT1, BLM, BMPR2, BRIP1, BUB1, BUB1B, CDC2, CDC6, CDC7, CDK2, CENPE, CHEK1, DDX11, DDX12, DNA2, ERCC6L, GALNAC4S-6ST, HELLS, HK2, HSPA12A, ITPKC, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MAP2K3, MAP3K4, MAP3K8, MCM2, MCM3, MCM5, MCM6, MCM7, MELK, MKI67, MSH2, MVD, MYO1D, NEK2, ORC1L, P2RX4, PCTK2, PDGFRB, PKMYT1, PLK1, PLK3, PLK4, POLQ, PRKG1, RAD54B, RAD54L, RECQL4, RFC2, RFC4, RRM1, SGK1, SMC2, SMC4, SQLE, STK38L, TGFBR1, TK1, TOP2A, TPX2, TRIB1, TRIP13, TTF2, TTK, UBA7, UBE2C, VRK1, WEE1	855	adenyl nucleotide binding
GO:0003887	1.119e-02	1.178	7 POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ	18	DNA-directed DNA polymerase activity
GO:0005102	1.351e-02	26.17	46 ADAMTS5, ANG, ANGPTL2, ANGPTL4, AREG, BMP2, BMP6, BRCA1, CCL11, CCL2, CCL7, CXCL1, CXCL2, CXCL6, ECM2, FEM1B, FGF1, FGF2, FGF7, GDF15, GPNMB, GRN, HBEGF, ICAM1, IL11, IL1A, IL1B, IL6, IL8, INHBA, LAMA5, LIF, MFAP4, MTSS1, NAMPT, P2RX4, PDGFA, PDGFD, PDGFRB, PLXNC1, PTHLH, SECTM1, TGFBR1, TNFSF4, TNFSF9, VEGFA	400	receptor binding
GO:0003697	2.021e-02	2.617	10 BLM, BRCA2, HMGB2, HNRNPA2B1, MCM4, MCM6, MCM7, MSH2, RAD51AP1, RPA3	40	single-stranded DNA binding
GO:0034061	2.547e-02	1.374	7 POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ	21	DNA polymerase activity
GO:0003774	4.204e-02	4.58	13 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, MYO1D	70	motor activity

Id	Pvalue	ExpCount	Count	Size	Term
03030	7.549e-13	2.676	21 DNA2, FEN1, LIG1, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, PRIM1, RFC2, RFC3, RFC4, RNASEH2A, RPA3	33	DNA replication
04110	2.405e-09	7.948	31 BUB1, BUB1B, CCNA2, CCNB1, CCNB2, CCNE2, CDC14B, CDC2, CDC20, CDC25A, CDC45L, CDC6, CDC7, CDK2, CHEK1, DBF4, ESPL1, MAD2L1, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, ORC1L, ORC6L, PKMYT1, PLK1, PTTG1, RBL1, WEE1	98	Cell cycle
04060	4.777e-04	9.327	25 BMP2, BMPR2, CCL11, CCL2, CCL7, CXCL1, CXCL2, CXCL3, CXCL6, IL11, IL15RA, IL1A, IL1B, IL1RAP, IL6, IL8, INHBA, LIF, OSMR, PDGFA, PDGFRB, TGFBR1, TNFSF4, TNFSF9, VEGFA	115	Cytokine-cytokine receptor interaction
00100	7.773e-04	1.865	10 CYP51A1, DHCR7, HMGCR, IDI1, IDI2, LSS, MVD, SC4MOL, SQLE, TM7SF2	23	Biosynthesis of steroids
03430	3.200e-03	1.784	9 EXO1, LIG1, MSH2, POLD1, POLD3, RFC2, RFC3, RFC4, RPA3	22	Mismatch repair
03410	6.976e-03	2.433	10 FEN1, HMGB1L10, LIG1, NEIL3, PARP2, POLD1, POLD3, POLE, POLE2, UNG	30	Base excision repair
03440	3.274e-02	2.028	8 BLM, BRCA2, MRE11A, POLD1, POLD3, RAD54B, RAD54L, RPA3	25	Homologous recombination

No enriched terms

No enriched terms

Entrez genes

ABCA5ATP-binding cassette, sub-family A (ABC1), member 5 (213353_at), score: 0.55 ABHD10abhydrolase domain containing 10 (218633_x_at), score: -0.77 ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 5 (219935_at), score: 0.55 ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide (209612_s_at), score: 0.59 ADIPOR2adiponectin receptor 2 (201346_at), score: 0.43 AEBP1AE binding protein 1 (201792_at), score: 0.4 ALDH6A1aldehyde dehydrogenase 6 family, member A1 (221589_s_at), score: 0.5 ALDOCaldolase C, fructose-bisphosphate (202022_at), score: 0.53 ANGangiogenin, ribonuclease, RNase A family, 5 (213397_x_at), score: 0.5 ANGPTL2angiopoietin-like 2 (213004_at), score: 0.47 ANGPTL4angiopoietin-like 4 (221009_s_at), score: 0.89 ANK2ankyrin 2, neuronal (202920_at), score: 0.71 ANP32Eacidic (leucine-rich) nuclear phosphoprotein 32 family, member E (208103_s_at), score: -0.74 ANXA3annexin A3 (209369_at), score: 0.4 AQP3aquaporin 3 (Gill blood group) (39248_at), score: 0.53 AREGamphiregulin (205239_at), score: 0.57 ARHGAP11ARho GTPase activating protein 11A (204492_at), score: -0.86 ARHGAP19Rho GTPase activating protein 19 (212738_at), score: -0.84 ARHGAP5Rho GTPase activating protein 5 (217936_at), score: 0.44 ARID5AAT rich interactive domain 5A (MRF1-like) (213138_at), score: 0.54 ARL6IP1ADP-ribosylation factor-like 6 interacting protein 1 (211935_at), score: -0.76 ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (206414_s_at), score: 0.48 ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae) (218115_at), score: -0.84 ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila) (219918_s_at), score: -0.88 ASPNasporin (219087_at), score: 0.44 ATF3activating transcription factor 3 (202672_s_at), score: 0.44 ATP13A3ATPase type 13A3 (219558_at), score: 0.54 ATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (212361_s_at), score: 0.47 AURKAaurora kinase A (208079_s_at), score: -0.87 AURKBaurora kinase B (209464_at), score: -0.93 B3GNT2UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (219326_s_at), score: 0.6 BARD1BRCA1 associated RING domain 1 (205345_at), score: -0.82 BAT1HLA-B associated transcript 1 (200041_s_at), score: -0.74 BBS1Bardet-Biedl syndrome 1 (218471_s_at), score: 0.49 BCL7AB-cell CLL/lymphoma 7A (203795_s_at), score: 0.39 BHLHE40basic helix-loop-helix family, member e40 (201170_s_at), score: 0.47 BIRC5baculoviral IAP repeat-containing 5 (202095_s_at), score: -0.93 BLMBloom syndrome (205733_at), score: -0.85 BMP2bone morphogenetic protein 2 (205289_at), score: 0.71 BMP6bone morphogenetic protein 6 (206176_at), score: 0.59 BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase) (210214_s_at), score: 0.45 BNC1basonuclin 1 (206581_at), score: 0.42 BRCA1breast cancer 1, early onset (204531_s_at), score: -0.81 BRCA2breast cancer 2, early onset (208368_s_at), score: -0.84 BRIP1BRCA1 interacting protein C-terminal helicase 1 (221703_at), score: -0.74 BUB1budding uninhibited by benzimidazoles 1 homolog (yeast) (209642_at), score: -0.88 BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast) (203755_at), score: -0.89 C10orf72chromosome 10 open reading frame 72 (213381_at), score: 0.48 C12orf48chromosome 12 open reading frame 48 (220060_s_at), score: -0.82 C13orf15chromosome 13 open reading frame 15 (218723_s_at), score: 0.47 C14orf1chromosome 14 open reading frame 1 (217188_s_at), score: 0.52 C14orf143chromosome 14 open reading frame 143 (214264_s_at), score: -0.76 C16orf53chromosome 16 open reading frame 53 (218300_at), score: -0.78 C17orf91chromosome 17 open reading frame 91 (214696_at), score: 0.84 C18orf24chromosome 18 open reading frame 24 (217640_x_at), score: -0.9 C1orf112chromosome 1 open reading frame 112 (220840_s_at), score: -0.77 C1orf135chromosome 1 open reading frame 135 (220011_at), score: -0.83 C1orf56chromosome 1 open reading frame 56 (221222_s_at), score: 0.42 C1Rcomplement component 1, r subcomponent (212067_s_at), score: 0.62 C1RLcomplement component 1, r subcomponent-like (218983_at), score: 0.47 C1Scomplement component 1, s subcomponent (208747_s_at), score: 0.46 C21orf45chromosome 21 open reading frame 45 (219004_s_at), score: -0.97 C4orf18chromosome 4 open reading frame 18 (219872_at), score: 0.67 C6orf145chromosome 6 open reading frame 145 (212923_s_at), score: 0.47 C9orf40chromosome 9 open reading frame 40 (218904_s_at), score: -0.75 CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (211368_s_at), score: 0.55 CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b (209682_at), score: 0.55 CBR3carbonyl reductase 3 (205379_at), score: -0.79 CCDC15coiled-coil domain containing 15 (220466_at), score: -0.79 CCL11chemokine (C-C motif) ligand 11 (210133_at), score: 0.54 CCL2chemokine (C-C motif) ligand 2 (216598_s_at), score: 0.64 CCL7chemokine (C-C motif) ligand 7 (208075_s_at), score: 0.57 CCNA2cyclin A2 (203418_at), score: -0.87 CCNB1cyclin B1 (214710_s_at), score: -0.83 CCNB2cyclin B2 (202705_at), score: -0.86 CCNE2cyclin E2 (205034_at), score: -0.88 CCNFcyclin F (204826_at), score: -0.84 CCNJcyclin J (219470_x_at), score: 0.46 CD302CD302 molecule (203799_at), score: 0.67 CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group) (201925_s_at), score: 0.46 CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae) (208022_s_at), score: 0.4 CDC2cell division cycle 2, G1 to S and G2 to M (203213_at), score: -0.78 CDC20cell division cycle 20 homolog (S. cerevisiae) (202870_s_at), score: -0.87 CDC25Acell division cycle 25 homolog A (S. pombe) (204695_at), score: -0.79 CDC45LCDC45 cell division cycle 45-like (S. cerevisiae) (204126_s_at), score: -0.9 CDC6cell division cycle 6 homolog (S. cerevisiae) (203967_at), score: -0.86 CDC7cell division cycle 7 homolog (S. cerevisiae) (204510_at), score: -0.85 CDCA3cell division cycle associated 3 (221436_s_at), score: -0.85 CDCA4cell division cycle associated 4 (218399_s_at), score: -0.78 CDCA8cell division cycle associated 8 (221520_s_at), score: -0.91 CDK2cyclin-dependent kinase 2 (204252_at), score: -0.93 CDKN3cyclin-dependent kinase inhibitor 3 (209714_s_at), score: -0.79 CDT1chromatin licensing and DNA replication factor 1 (209832_s_at), score: -0.86 CDYLchromodomain protein, Y-like (203100_s_at), score: 0.49 CENPAcentromere protein A (204962_s_at), score: -0.85 CENPEcentromere protein E, 312kDa (205046_at), score: -0.85 CENPFcentromere protein F, 350/400ka (mitosin) (207828_s_at), score: -0.88 CENPIcentromere protein I (214804_at), score: -0.81 CENPMcentromere protein M (218741_at), score: -0.92 CENPOcentromere protein O (219472_at), score: -0.77 CEP152centrosomal protein 152kDa (215170_s_at), score: -0.74 CEP55centrosomal protein 55kDa (218542_at), score: -0.85 CEP97centrosomal protein 97kDa (219886_at), score: -0.74 CHAF1Achromatin assembly factor 1, subunit A (p150) (214426_x_at), score: -0.94 CHAF1Bchromatin assembly factor 1, subunit B (p60) (204775_at), score: -0.85 CHEK1CHK1 checkpoint homolog (S. pombe) (205393_s_at), score: -0.8 CHIC2cysteine-rich hydrophobic domain 2 (219492_at), score: 0.38 CHMP1Bchromatin modifying protein 1B (218178_s_at), score: 0.48 CHST2carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 (203921_at), score: 0.53 CKAP2cytoskeleton associated protein 2 (218252_at), score: -0.98 CKS1BCDC28 protein kinase regulatory subunit 1B (201897_s_at), score: -0.77 CLEC3BC-type lectin domain family 3, member B (205200_at), score: 0.46 CLIP3CAP-GLY domain containing linker protein 3 (212358_at), score: 0.39 COL14A1collagen, type XIV, alpha 1 (212865_s_at), score: 0.7 COL15A1collagen, type XV, alpha 1 (203477_at), score: 0.77 COL21A1collagen, type XXI, alpha 1 (208096_s_at), score: 0.6 CORINcorin, serine peptidase (220356_at), score: 0.58 CP110CP110 protein (204662_at), score: -0.78 CPA3carboxypeptidase A3 (mast cell) (205624_at), score: 0.7 CPA4carboxypeptidase A4 (205832_at), score: 0.4 CREG1cellular repressor of E1A-stimulated genes 1 (201200_at), score: 0.55 CRISPLD2cysteine-rich secretory protein LCCL domain containing 2 (221541_at), score: 0.5 CScitrate synthase (208660_at), score: -0.79 CSGALNACT2chondroitin sulfate N-acetylgalactosaminyltransferase 2 (222235_s_at), score: 0.4 CTSDcathepsin D (200766_at), score: 0.53 CTSFcathepsin F (203657_s_at), score: 0.59 CTSOcathepsin O (203758_at), score: 0.62 CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (204470_at), score: 0.39 CXCL2chemokine (C-X-C motif) ligand 2 (209774_x_at), score: 0.45 CXCL3chemokine (C-X-C motif) ligand 3 (207850_at), score: 0.7 CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) (206336_at), score: 0.49 CXCR7chemokine (C-X-C motif) receptor 7 (212977_at), score: 0.63 CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1 (216607_s_at), score: 0.66 DAAM2dishevelled associated activator of morphogenesis 2 (212793_at), score: 0.47 DACT1dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) (219179_at), score: 0.53 DBF4DBF4 homolog (S. cerevisiae) (204244_s_at), score: -0.77 DCNdecorin (211896_s_at), score: 0.45 DCP1ADCP1 decapping enzyme homolog A (S. cerevisiae) (218508_at), score: 0.43 DDX11DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) (208149_x_at), score: -0.84 DDX12DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 (CHL1-like helicase homolog, S. cerevisiae) (213378_s_at), score: -0.8 DEKDEK oncogene (200934_at), score: -0.82 DEPDC1DEP domain containing 1 (220295_x_at), score: -0.9 DHCR77-dehydrocholesterol reductase (201790_s_at), score: 0.66 DHFRdihydrofolate reductase (202533_s_at), score: -0.86 DKK2dickkopf homolog 2 (Xenopus laevis) (219908_at), score: 0.64 DLEU2deleted in lymphocytic leukemia 2 (non-protein coding) (216870_x_at), score: -0.88 DLEU2Ldeleted in lymphocytic leukemia 2-like (215629_s_at), score: -0.91 DLGAP5discs, large (Drosophila) homolog-associated protein 5 (203764_at), score: -0.89 DMDdystrophin (203881_s_at), score: 0.5 DNA2DNA replication helicase 2 homolog (yeast) (213647_at), score: -0.81 DNAJC9DnaJ (Hsp40) homolog, subfamily C, member 9 (213088_s_at), score: -0.86 DNASE2deoxyribonuclease II, lysosomal (214992_s_at), score: 0.44 DOCK9dedicator of cytokinesis 9 (212538_at), score: 0.4 DPP4dipeptidyl-peptidase 4 (211478_s_at), score: 0.61 DPTdermatopontin (213068_at), score: 0.45 DRAMdamage-regulated autophagy modulator (218627_at), score: 0.62 DSCC1defective in sister chromatid cohesion 1 homolog (S. cerevisiae) (219000_s_at), score: -0.83 DSN1DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) (219512_at), score: -0.92 DTLdenticleless homolog (Drosophila) (218585_s_at), score: -0.87 DUSP5dual specificity phosphatase 5 (209457_at), score: 0.42 DVL3dishevelled, dsh homolog 3 (Drosophila) (201908_at), score: 0.42 E2F8E2F transcription factor 8 (219990_at), score: -0.82 ECM2extracellular matrix protein 2, female organ and adipocyte specific (206101_at), score: 0.62 ECT2epithelial cell transforming sequence 2 oncogene (219787_s_at), score: -0.78 EGR2early growth response 2 (Krox-20 homolog, Drosophila) (205249_at), score: 0.69 EGR3early growth response 3 (206115_at), score: 0.52 ENTPD7ectonucleoside triphosphate diphosphohydrolase 7 (220153_at), score: 0.61 ERCC6Lexcision repair cross-complementing rodent repair deficiency, complementation group 6-like (219650_at), score: -0.9 ERI2exoribonuclease 2 (213365_at), score: -0.87 ESPL1extra spindle pole bodies homolog 1 (S. cerevisiae) (38158_at), score: -0.75 EVCEllis van Creveld syndrome (219432_at), score: 0.39 EXO1exonuclease 1 (204603_at), score: -0.82 EXOSC8exosome component 8 (215136_s_at), score: -0.77 EXOSC9exosome component 9 (205061_s_at), score: -0.92 EZH2enhancer of zeste homolog 2 (Drosophila) (203358_s_at), score: -0.95 F10coagulation factor X (205620_at), score: 0.73 F3coagulation factor III (thromboplastin, tissue factor) (204363_at), score: 0.44 FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (214285_at), score: 0.71 FADS1fatty acid desaturase 1 (208963_x_at), score: 0.43 FAM64Afamily with sequence similarity 64, member A (221591_s_at), score: -0.85 FANCAFanconi anemia, complementation group A (203805_s_at), score: -0.79 FANCGFanconi anemia, complementation group G (203564_at), score: -0.91 FANCIFanconi anemia, complementation group I (213007_at), score: -0.86 FAPfibroblast activation protein, alpha (209955_s_at), score: 0.46 FBXO5F-box protein 5 (218875_s_at), score: -0.79 FBXW7F-box and WD repeat domain containing 7 (218751_s_at), score: 0.62 FCGRTFc fragment of IgG, receptor, transporter, alpha (218831_s_at), score: 0.64 FEM1Bfem-1 homolog b (C. elegans) (212367_at), score: 0.44 FEN1flap structure-specific endonuclease 1 (204768_s_at), score: -0.84 FGF1fibroblast growth factor 1 (acidic) (205117_at), score: 0.62 FGF2fibroblast growth factor 2 (basic) (204421_s_at), score: 0.39 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: 0.73 FOSBFBJ murine osteosarcoma viral oncogene homolog B (202768_at), score: 0.79 FOXM1forkhead box M1 (202580_x_at), score: -0.85 FOXO3forkhead box O3 (204132_s_at), score: 0.44 FRYfurry homolog (Drosophila) (204072_s_at), score: 0.6 FTH1ferritin, heavy polypeptide 1 (214211_at), score: 0.39 GAAglucosidase, alpha; acid (202812_at), score: 0.46 GABARAPL1GABA(A) receptor-associated protein like 1 (208868_s_at), score: 0.62 GABARAPL3GABA(A) receptors associated protein like 3 (pseudogene) (211458_s_at), score: 0.58 GALNAC4S-6STB cell RAG associated protein (203066_at), score: 0.58 GCH1GTP cyclohydrolase 1 (204224_s_at), score: 0.63 GDF15growth differentiation factor 15 (221577_x_at), score: 0.49 GDPD5glycerophosphodiester phosphodiesterase domain containing 5 (32502_at), score: 0.47 GEMGTP binding protein overexpressed in skeletal muscle (204472_at), score: 0.75 GFPT2glutamine-fructose-6-phosphate transaminase 2 (205100_at), score: 0.65 GINS1GINS complex subunit 1 (Psf1 homolog) (206102_at), score: -0.96 GINS2GINS complex subunit 2 (Psf2 homolog) (221521_s_at), score: -0.95 GINS3GINS complex subunit 3 (Psf3 homolog) (45633_at), score: -0.92 GINS4GINS complex subunit 4 (Sld5 homolog) (211767_at), score: -0.83 GMNNgeminin, DNA replication inhibitor (218350_s_at), score: -0.88 GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (212959_s_at), score: 0.55 GPNMBglycoprotein (transmembrane) nmb (201141_at), score: 0.6 GPR183G protein-coupled receptor 183 (205419_at), score: 0.62 GPR37G protein-coupled receptor 37 (endothelin receptor type B-like) (209631_s_at), score: 0.53 GRIA1glutamate receptor, ionotropic, AMPA 1 (209793_at), score: 0.41 GRIA3glutamate receptor, ionotrophic, AMPA 3 (206730_at), score: 0.43 GRNgranulin (211284_s_at), score: 0.4 GSTM1glutathione S-transferase mu 1 (204550_x_at), score: 0.64 GSTM2glutathione S-transferase mu 2 (muscle) (204418_x_at), score: 0.54 GTSE1G-2 and S-phase expressed 1 (204318_s_at), score: -0.87 H6PDhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (221892_at), score: 0.45 HBEGFheparin-binding EGF-like growth factor (203821_at), score: 0.6 HELLShelicase, lymphoid-specific (220085_at), score: -0.83 HERC6hect domain and RLD 6 (219352_at), score: 0.41 HIPK3homeodomain interacting protein kinase 3 (210148_at), score: 0.4 HIRIP3HIRA interacting protein 3 (204504_s_at), score: -0.74 HIVEP1human immunodeficiency virus type I enhancer binding protein 1 (204512_at), score: 0.7 HIVEP2human immunodeficiency virus type I enhancer binding protein 2 (212642_s_at), score: 0.63 HJURPHolliday junction recognition protein (218726_at), score: -0.83 HK2hexokinase 2 (202934_at), score: 0.59 HLXH2.0-like homeobox (214438_at), score: 0.56 HMGB1L10high-mobility group box 1-like 10 (216508_x_at), score: -0.83 HMGB2high-mobility group box 2 (208808_s_at), score: -0.92 HMGB3high-mobility group box 3 (203744_at), score: -0.79 HMGB3L1high-mobility group box 3-like 1 (216548_x_at), score: -0.76 HMGCR3-hydroxy-3-methylglutaryl-Coenzyme A reductase (202539_s_at), score: 0.43 HMGCS13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) (221750_at), score: 0.51 HMGN2high-mobility group nucleosomal binding domain 2 (208668_x_at), score: -0.82 HMMRhyaluronan-mediated motility receptor (RHAMM) (207165_at), score: -0.88 HMOX1heme oxygenase (decycling) 1 (203665_at), score: 0.48 HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B1 (205292_s_at), score: -0.8 HSD17B2hydroxysteroid (17-beta) dehydrogenase 2 (204818_at), score: 0.4 HSPA12Aheat shock 70kDa protein 12A (214434_at), score: 0.38 HSPB3heat shock 27kDa protein 3 (206375_s_at), score: 0.48 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (207135_at), score: 0.5 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: 0.79 IDI1isopentenyl-diphosphate delta isomerase 1 (204615_x_at), score: 0.65 IDI2isopentenyl-diphosphate delta isomerase 2 (217631_at), score: 0.39 IER3immediate early response 3 (201631_s_at), score: 0.4 IFITM1interferon induced transmembrane protein 1 (9-27) (214022_s_at), score: 0.39 IL11interleukin 11 (206924_at), score: 0.62 IL15RAinterleukin 15 receptor, alpha (207375_s_at), score: 0.41 IL1Ainterleukin 1, alpha (210118_s_at), score: 0.49 IL1Binterleukin 1, beta (39402_at), score: 0.53 IL1RAPinterleukin 1 receptor accessory protein (205227_at), score: 0.47 IL1RL1interleukin 1 receptor-like 1 (207526_s_at), score: 0.62 IL6interleukin 6 (interferon, beta 2) (205207_at), score: 0.91 IL8interleukin 8 (211506_s_at), score: 0.82 INHBAinhibin, beta A (210511_s_at), score: 0.5 INSIG1insulin induced gene 1 (201627_s_at), score: 0.83 ITGA1integrin, alpha 1 (214660_at), score: 0.56 ITGB3BPintegrin beta 3 binding protein (beta3-endonexin) (205176_s_at), score: -0.76 ITPKCinositol 1,4,5-trisphosphate 3-kinase C (213076_at), score: 0.46 JARID2jumonji, AT rich interactive domain 2 (203297_s_at), score: 0.55 JHDM1Djumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (221778_at), score: 0.78 JMJD3jumonji domain containing 3, histone lysine demethylase (213146_at), score: 0.81 JMJD6jumonji domain containing 6 (212722_s_at), score: 0.46 JUNDjun D proto-oncogene (203751_x_at), score: 0.49 KCND3potassium voltage-gated channel, Shal-related subfamily, member 3 (213832_at), score: 0.54 KHSRPKH-type splicing regulatory protein (204372_s_at), score: -0.74 KIAA0247KIAA0247 (202181_at), score: 0.56 KIAA0586KIAA0586 (205631_at), score: -0.83 KIAA1024KIAA1024 (215081_at), score: 0.59 KIAA1644KIAA1644 (52837_at), score: 0.53 KIF11kinesin family member 11 (204444_at), score: -0.91 KIF14kinesin family member 14 (206364_at), score: -0.88 KIF15kinesin family member 15 (219306_at), score: -0.89 KIF18Akinesin family member 18A (221258_s_at), score: -0.8 KIF18Bkinesin family member 18B (222039_at), score: -0.95 KIF20Akinesin family member 20A (218755_at), score: -0.78 KIF20Bkinesin family member 20B (205235_s_at), score: -0.92 KIF22kinesin family member 22 (202183_s_at), score: -0.89 KIF23kinesin family member 23 (204709_s_at), score: -0.82 KIF2Ckinesin family member 2C (209408_at), score: -0.85 KIF4Akinesin family member 4A (218355_at), score: -0.93 KLF7Kruppel-like factor 7 (ubiquitous) (204334_at), score: 0.47 KLHL21kelch-like 21 (Drosophila) (203068_at), score: 0.49 KNTC1kinetochore associated 1 (206316_s_at), score: -0.82 LAMA5laminin, alpha 5 (210150_s_at), score: 0.45 LBHlimb bud and heart development homolog (mouse) (221011_s_at), score: 0.45 LDLRlow density lipoprotein receptor (202068_s_at), score: 0.5 LHFPlipoma HMGIC fusion partner (218656_s_at), score: 0.61 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: 0.8 LIG1ligase I, DNA, ATP-dependent (202726_at), score: -0.84 LIPAlipase A, lysosomal acid, cholesterol esterase (201847_at), score: 0.39 LMBRD1LMBR1 domain containing 1 (218191_s_at), score: 0.57 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: 0.84 LMNB1lamin B1 (203276_at), score: -0.91 LMNB2lamin B2 (216952_s_at), score: -0.75 LOH3CR2Aloss of heterozygosity, 3, chromosomal region 2, gene A (220244_at), score: 0.78 LPPR4plasticity related gene 1 (213496_at), score: 0.43 LRIG1leucine-rich repeats and immunoglobulin-like domains 1 (211596_s_at), score: 0.61 LRP1low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) (200785_s_at), score: 0.4 LRRC32leucine rich repeat containing 32 (203835_at), score: 0.44 LSM2LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) (209449_at), score: -0.81 LSSlanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (211019_s_at), score: 0.46 LYSTlysosomal trafficking regulator (203518_at), score: 0.52 LZTFL1leucine zipper transcription factor-like 1 (218437_s_at), score: 0.54 MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast) (203362_s_at), score: -1 MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) (209348_s_at), score: 0.46 MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) (36711_at), score: 0.45 MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2 (209737_at), score: 0.55 MAN1A1mannosidase, alpha, class 1A, member 1 (221760_at), score: 0.45 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: 0.68 MAN2B2mannosidase, alpha, class 2B, member 2 (214703_s_at), score: 0.38 MAP2K3mitogen-activated protein kinase kinase 3 (207667_s_at), score: 0.45 MAP3K4mitogen-activated protein kinase kinase kinase 4 (216199_s_at), score: 0.46 MAP3K8mitogen-activated protein kinase kinase kinase 8 (205027_s_at), score: 0.4 MARCH2membrane-associated ring finger (C3HC4) 2 (210075_at), score: 0.44 MAXMYC associated factor X (210734_x_at), score: 0.39 MCM10minichromosome maintenance complex component 10 (220651_s_at), score: -0.94 MCM2minichromosome maintenance complex component 2 (202107_s_at), score: -0.91 MCM3minichromosome maintenance complex component 3 (201555_at), score: -0.87 MCM4minichromosome maintenance complex component 4 (212141_at), score: -0.86 MCM5minichromosome maintenance complex component 5 (216237_s_at), score: -0.95 MCM6minichromosome maintenance complex component 6 (201930_at), score: -0.81 MCM7minichromosome maintenance complex component 7 (210983_s_at), score: -0.89 MDM1Mdm1 nuclear protein homolog (mouse) (213761_at), score: -0.79 MEIS3P1Meis homeobox 3 pseudogene 1 (214077_x_at), score: 0.42 MELKmaternal embryonic leucine zipper kinase (204825_at), score: -0.79 MFAP4microfibrillar-associated protein 4 (212713_at), score: 0.77 MKI67antigen identified by monoclonal antibody Ki-67 (212022_s_at), score: -0.86 MLF1IPMLF1 interacting protein (218883_s_at), score: -0.84 MLXIPMLX interacting protein (202519_at), score: 0.43 MPHOSPH9M-phase phosphoprotein 9 (206205_at), score: -0.75 MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae) (205395_s_at), score: -0.81 MSCmusculin (activated B-cell factor-1) (209928_s_at), score: 0.54 MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (209421_at), score: -0.81 MTSS1metastasis suppressor 1 (203037_s_at), score: 0.55 MVDmevalonate (diphospho) decarboxylase (203027_s_at), score: 0.39 MXRA5matrix-remodelling associated 5 (209596_at), score: 0.48 MYBL1v-myb myeloblastosis viral oncogene homolog (avian)-like 1 (213906_at), score: -0.78 MYBL2v-myb myeloblastosis viral oncogene homolog (avian)-like 2 (201710_at), score: -0.8 MYCv-myc myelocytomatosis viral oncogene homolog (avian) (202431_s_at), score: 0.43 MYO1Dmyosin ID (212338_at), score: 0.55 NAMPTnicotinamide phosphoribosyltransferase (217738_at), score: 0.64 NASPnuclear autoantigenic sperm protein (histone-binding) (201970_s_at), score: -0.86 NCAPD2non-SMC condensin I complex, subunit D2 (201774_s_at), score: -0.82 NCAPD3non-SMC condensin II complex, subunit D3 (212789_at), score: -0.88 NCAPGnon-SMC condensin I complex, subunit G (218663_at), score: -0.89 NCAPG2non-SMC condensin II complex, subunit G2 (219588_s_at), score: -0.89 NCAPHnon-SMC condensin I complex, subunit H (212949_at), score: -0.88 NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae) (204162_at), score: -0.88 NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 1 (208093_s_at), score: 0.39 NDRG1N-myc downstream regulated 1 (200632_s_at), score: 0.54 NEDD9neural precursor cell expressed, developmentally down-regulated 9 (202149_at), score: 0.53 NEIL3nei endonuclease VIII-like 3 (E. coli) (219502_at), score: -0.84 NEK2NIMA (never in mitosis gene a)-related kinase 2 (204641_at), score: -0.84 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: 0.77 NFIL3nuclear factor, interleukin 3 regulated (203574_at), score: 0.64 NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: 0.58 NINJ1ninjurin 1 (203045_at), score: 0.54 NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (201866_s_at), score: 0.51 NR4A1nuclear receptor subfamily 4, group A, member 1 (202340_x_at), score: 0.61 NR4A2nuclear receptor subfamily 4, group A, member 2 (216248_s_at), score: 0.58 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: 0.87 NSMCE4Anon-SMC element 4 homolog A (S. cerevisiae) (219067_s_at), score: -0.75 NUP107nucleoporin 107kDa (218768_at), score: -0.82 NUP155nucleoporin 155kDa (206550_s_at), score: -0.81 NUP93nucleoporin 93kDa (202188_at), score: -0.84 NUSAP1nucleolar and spindle associated protein 1 (218039_at), score: -0.9 OIP5Opa interacting protein 5 (213599_at), score: -0.86 OLFML1olfactomedin-like 1 (217525_at), score: 0.4 OLFML2Aolfactomedin-like 2A (213075_at), score: 0.71 OMDosteomodulin (205907_s_at), score: 0.5 OPTNoptineurin (202073_at), score: 0.4 ORAI3ORAI calcium release-activated calcium modulator 3 (221864_at), score: 0.39 ORC1Lorigin recognition complex, subunit 1-like (yeast) (205085_at), score: -0.81 ORC6Lorigin recognition complex, subunit 6 like (yeast) (219105_x_at), score: -0.96 OSMRoncostatin M receptor (205729_at), score: 0.46 P2RX4purinergic receptor P2X, ligand-gated ion channel, 4 (204088_at), score: 0.41 PAPPApregnancy-associated plasma protein A, pappalysin 1 (201981_at), score: 0.5 PARP2poly (ADP-ribose) polymerase 2 (214086_s_at), score: -0.86 PBKPDZ binding kinase (219148_at), score: -0.82 PCNTpericentrin (203660_s_at), score: -0.81 PCTK2PCTAIRE protein kinase 2 (221918_at), score: 0.39 PDGFAplatelet-derived growth factor alpha polypeptide (205463_s_at), score: 0.59 PDGFDplatelet derived growth factor D (219304_s_at), score: 0.81 PDGFRBplatelet-derived growth factor receptor, beta polypeptide (202273_at), score: 0.64 PDGFRLplatelet-derived growth factor receptor-like (205226_at), score: 0.51 PDPNpodoplanin (221898_at), score: 0.44 PEG10paternally expressed 10 (212094_at), score: -0.85 PELI1pellino homolog 1 (Drosophila) (218319_at), score: 0.39 PGCPplasma glutamate carboxypeptidase (203501_at), score: 0.45 PGRMC2progesterone receptor membrane component 2 (213227_at), score: 0.39 PIGZphosphatidylinositol glycan anchor biosynthesis, class Z (220041_at), score: 0.41 PIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide (203879_at), score: 0.69 PKMYT1protein kinase, membrane associated tyrosine/threonine 1 (204267_x_at), score: -0.87 PLA2G4Cphospholipase A2, group IVC (cytosolic, calcium-independent) (209785_s_at), score: 0.42 PLK1polo-like kinase 1 (Drosophila) (202240_at), score: -0.78 PLK3polo-like kinase 3 (Drosophila) (204958_at), score: 0.44 PLK4polo-like kinase 4 (Drosophila) (204887_s_at), score: -0.79 PLSCR4phospholipid scramblase 4 (218901_at), score: 0.67 PLXNC1plexin C1 (213241_at), score: 0.48 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: 0.82 POLA1polymerase (DNA directed), alpha 1, catalytic subunit (204835_at), score: -0.99 POLA2polymerase (DNA directed), alpha 2 (70kD subunit) (204441_s_at), score: -0.85 POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa (203422_at), score: -0.93 POLD3polymerase (DNA-directed), delta 3, accessory subunit (212836_at), score: -0.78 POLEpolymerase (DNA directed), epsilon (216026_s_at), score: -0.86 POLE2polymerase (DNA directed), epsilon 2 (p59 subunit) (205909_at), score: -0.88 POLQpolymerase (DNA directed), theta (219510_at), score: -0.84 POLR2Dpolymerase (RNA) II (DNA directed) polypeptide D (203664_s_at), score: -0.78 PPARDperoxisome proliferator-activated receptor delta (37152_at), score: 0.46 PPLperiplakin (203407_at), score: 0.9 PPP3CCprotein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (207000_s_at), score: 0.42 PRC1protein regulator of cytokinesis 1 (218009_s_at), score: -0.82 PRELPproline/arginine-rich end leucine-rich repeat protein (204223_at), score: 0.7 PRIM1primase, DNA, polypeptide 1 (49kDa) (205053_at), score: -0.9 PRKG1protein kinase, cGMP-dependent, type I (207119_at), score: 0.74 PROS1protein S (alpha) (207808_s_at), score: 0.47 PRPS2phosphoribosyl pyrophosphate synthetase 2 (203401_at), score: -0.74 PRR11proline rich 11 (219392_x_at), score: -0.81 PRSS12protease, serine, 12 (neurotrypsin, motopsin) (205515_at), score: 0.5 PSMC3IPPSMC3 interacting protein (213951_s_at), score: -0.92 PSRC1proline/serine-rich coiled-coil 1 (201896_s_at), score: -0.84 PTGDSprostaglandin D2 synthase 21kDa (brain) (212187_x_at), score: 0.39 PTGESprostaglandin E synthase (210367_s_at), score: 0.49 PTHLHparathyroid hormone-like hormone (211756_at), score: 0.68 PTPREprotein tyrosine phosphatase, receptor type, E (221840_at), score: 0.44 PTTG1pituitary tumor-transforming 1 (203554_x_at), score: -0.84 QPRTquinolinate phosphoribosyltransferase (204044_at), score: 0.47 RAB33ARAB33A, member RAS oncogene family (206039_at), score: 0.52 RACGAP1Rac GTPase activating protein 1 (222077_s_at), score: -0.85 RAD51AP1RAD51 associated protein 1 (204146_at), score: -0.87 RAD54BRAD54 homolog B (S. cerevisiae) (219494_at), score: -0.89 RAD54LRAD54-like (S. cerevisiae) (204558_at), score: -0.84 RAD9ARAD9 homolog A (S. pombe) (204828_at), score: -0.76 RANGAP1Ran GTPase activating protein 1 (212125_at), score: -0.81 RAPGEF2Rap guanine nucleotide exchange factor (GEF) 2 (203097_s_at), score: 0.46 RASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated) (205590_at), score: 0.54 RASSF8Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 (207754_at), score: 0.4 RBL1retinoblastoma-like 1 (p107) (205296_at), score: -0.8 RCAN2regulator of calcineurin 2 (203498_at), score: 0.62 RCL1RNA terminal phosphate cyclase-like 1 (218544_s_at), score: 0.39 RECQL4RecQ protein-like 4 (213520_at), score: -0.75 RELv-rel reticuloendotheliosis viral oncogene homolog (avian) (206036_s_at), score: 0.44 RELBv-rel reticuloendotheliosis viral oncogene homolog B (205205_at), score: 0.5 RFC2replication factor C (activator 1) 2, 40kDa (203696_s_at), score: -0.82 RFC3replication factor C (activator 1) 3, 38kDa (204128_s_at), score: -0.85 RFC4replication factor C (activator 1) 4, 37kDa (204023_at), score: -0.93 RFWD3ring finger and WD repeat domain 3 (218564_at), score: -0.83 RGPD5RANBP2-like and GRIP domain containing 5 (210676_x_at), score: 0.43 RGS2regulator of G-protein signaling 2, 24kDa (202388_at), score: 0.47 RGS3regulator of G-protein signaling 3 (203823_at), score: 0.46 RHOQras homolog gene family, member Q (212119_at), score: 0.4 RMI1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (218979_at), score: -0.77 RNASE4ribonuclease, RNase A family, 4 (205158_at), score: 0.5 RNASEH2Aribonuclease H2, subunit A (203022_at), score: -0.89 RNF103ring finger protein 103 (202636_at), score: 0.45 RPA3replication protein A3, 14kDa (209507_at), score: -0.74 RPL39Lribosomal protein L39-like (210115_at), score: -0.8 RPP30ribonuclease P/MRP 30kDa subunit (203436_at), score: -0.8 RPRD2regulation of nuclear pre-mRNA domain containing 2 (212553_at), score: -0.76 RRADRas-related associated with diabetes (204802_at), score: 0.7 RRM1ribonucleotide reductase M1 (201476_s_at), score: -0.79 RRM2ribonucleotide reductase M2 polypeptide (209773_s_at), score: -0.75 RTN2reticulon 2 (34408_at), score: 0.41 RUNX1runt-related transcription factor 1 (209360_s_at), score: 0.74 RWDD2ARWD domain containing 2A (213555_at), score: 0.45 SAP30Sin3A-associated protein, 30kDa (204900_x_at), score: -0.74 SC4MOLsterol-C4-methyl oxidase-like (209146_at), score: 0.67 SCDstearoyl-CoA desaturase (delta-9-desaturase) (200832_s_at), score: 0.54 SECTM1secreted and transmembrane 1 (213716_s_at), score: 0.42 SERPINF1serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (202283_at), score: 0.47 SGK1serum/glucocorticoid regulated kinase 1 (201739_at), score: 0.62 SHCBP1SHC SH2-domain binding protein 1 (219493_at), score: -0.83 SHMT1serine hydroxymethyltransferase 1 (soluble) (209980_s_at), score: -0.74 SKILSKI-like oncogene (206675_s_at), score: 0.56 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: 0.73 SLC22A18solute carrier family 22, member 18 (204981_at), score: 0.51 SLC27A3solute carrier family 27 (fatty acid transporter), member 3 (222217_s_at), score: 0.4 SLC2A14solute carrier family 2 (facilitated glucose transporter), member 14 (222088_s_at), score: 0.58 SLC2A3solute carrier family 2 (facilitated glucose transporter), member 3 (202499_s_at), score: 0.43 SLC2A3P1solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 1 (221751_at), score: 0.56 SLC39A8solute carrier family 39 (zinc transporter), member 8 (209267_s_at), score: 0.47 SLC46A3solute carrier family 46, member 3 (214719_at), score: 0.64 SMC2structural maintenance of chromosomes 2 (204240_s_at), score: -0.88 SMC4structural maintenance of chromosomes 4 (201663_s_at), score: -0.78 SMOXspermine oxidase (210357_s_at), score: 0.82 SOD2superoxide dismutase 2, mitochondrial (221477_s_at), score: 0.56 SOX4SRY (sex determining region Y)-box 4 (201417_at), score: 0.55 SOX9SRY (sex determining region Y)-box 9 (202935_s_at), score: 0.58 SPAG5sperm associated antigen 5 (203145_at), score: -0.82 SPATA2Lspermatogenesis associated 2-like (214965_at), score: 0.62 SPC25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) (209891_at), score: -0.89 SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: 0.59 SPRY2sprouty homolog 2 (Drosophila) (204011_at), score: 0.47 SPRY4sprouty homolog 4 (Drosophila) (221489_s_at), score: 0.48 SPSB1splA/ryanodine receptor domain and SOCS box containing 1 (219677_at), score: 0.57 SQLEsqualene epoxidase (213562_s_at), score: 0.75 SREBF2sterol regulatory element binding transcription factor 2 (201247_at), score: 0.6 SRFserum response factor (c-fos serum response element-binding transcription factor) (202401_s_at), score: 0.58 ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (208322_s_at), score: 0.57 STILSCL/TAL1 interrupting locus (205339_at), score: -0.93 STK38Lserine/threonine kinase 38 like (212572_at), score: 0.81 STMN1stathmin 1/oncoprotein 18 (200783_s_at), score: -0.86 SUPT16Hsuppressor of Ty 16 homolog (S. cerevisiae) (217815_at), score: -0.78 SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila) (218619_s_at), score: -0.8 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: 0.75 TACC3transforming, acidic coiled-coil containing protein 3 (218308_at), score: -0.87 TACSTD2tumor-associated calcium signal transducer 2 (202286_s_at), score: 0.59 TELO2TEL2, telomere maintenance 2, homolog (S. cerevisiae) (34260_at), score: -0.77 TGFBR1transforming growth factor, beta receptor 1 (206943_at), score: 0.74 THAP10THAP domain containing 10 (219596_at), score: -0.75 THBDthrombomodulin (203887_s_at), score: 0.69 TICAM1toll-like receptor adaptor molecule 1 (213191_at), score: 0.45 TIMELESStimeless homolog (Drosophila) (203046_s_at), score: -0.86 TIPINTIMELESS interacting protein (219258_at), score: -0.75 TK1thymidine kinase 1, soluble (202338_at), score: -0.86 TM6SF1transmembrane 6 superfamily member 1 (219892_at), score: 0.57 TM7SF2transmembrane 7 superfamily member 2 (210130_s_at), score: 0.56 TMEM194Atransmembrane protein 194A (212621_at), score: -0.94 TMEM39Atransmembrane protein 39A (218615_s_at), score: 0.52 TMEM41Btransmembrane protein 41B (212623_at), score: 0.6 TMEM48transmembrane protein 48 (218073_s_at), score: -0.77 TNFAIP3tumor necrosis factor, alpha-induced protein 3 (202644_s_at), score: 0.47 TNFAIP6tumor necrosis factor, alpha-induced protein 6 (206026_s_at), score: 0.6 TNFAIP8tumor necrosis factor, alpha-induced protein 8 (210260_s_at), score: 0.5 TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (207426_s_at), score: 0.53 TNFSF9tumor necrosis factor (ligand) superfamily, member 9 (206907_at), score: 0.4 TNS3tensin 3 (217853_at), score: 0.49 TNXAtenascin XA pseudogene (213451_x_at), score: 0.55 TNXBtenascin XB (216333_x_at), score: 0.57 TOM1target of myb1 (chicken) (202807_s_at), score: 0.55 TOP2Atopoisomerase (DNA) II alpha 170kDa (201291_s_at), score: -0.74 TOPBP1topoisomerase (DNA) II binding protein 1 (202633_at), score: -0.78 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: 0.49 TPD52L1tumor protein D52-like 1 (203786_s_at), score: 0.46 TPP1tripeptidyl peptidase I (200742_s_at), score: 0.43 TPRKBTP53RK binding protein (219030_at), score: -0.76 TPST1tyrosylprotein sulfotransferase 1 (204140_at), score: 0.43 TPX2TPX2, microtubule-associated, homolog (Xenopus laevis) (210052_s_at), score: -0.91 TRAF3TNF receptor-associated factor 3 (221571_at), score: 0.4 TRAPPC6Atrafficking protein particle complex 6A (204985_s_at), score: 0.52 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: 0.65 TRIM22tripartite motif-containing 22 (213293_s_at), score: 0.45 TRIP13thyroid hormone receptor interactor 13 (204033_at), score: -0.91 TRMT5TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae) (221952_x_at), score: -0.87 TRPC6transient receptor potential cation channel, subfamily C, member 6 (217287_s_at), score: 0.46 TRPS1trichorhinophalangeal syndrome I (218502_s_at), score: 0.48 TSPAN9tetraspanin 9 (220968_s_at), score: 0.46 TTC17tetratricopeptide repeat domain 17 (218972_at), score: 0.65 TTF2transcription termination factor, RNA polymerase II (204407_at), score: -0.75 TTKTTK protein kinase (204822_at), score: -0.9 UBA7ubiquitin-like modifier activating enzyme 7 (203281_s_at), score: 0.53 UBE2Cubiquitin-conjugating enzyme E2C (202954_at), score: -0.81 UNGuracil-DNA glycosylase (202330_s_at), score: -0.81 USTuronyl-2-sulfotransferase (205139_s_at), score: 0.48 VBP1von Hippel-Lindau binding protein 1 (201472_at), score: -0.78 VCLvinculin (200930_s_at), score: 0.58 VDRvitamin D (1,25- dihydroxyvitamin D3) receptor (204255_s_at), score: 0.62 VEGFAvascular endothelial growth factor A (211527_x_at), score: 0.79 VRK1vaccinia related kinase 1 (203856_at), score: -0.82 WDHD1WD repeat and HMG-box DNA binding protein 1 (216228_s_at), score: -0.88 WDR62WD repeat domain 62 (215218_s_at), score: -0.76 WDR76WD repeat domain 76 (205519_at), score: -0.83 WEE1WEE1 homolog (S. pombe) (212533_at), score: -0.8 WHSC1Wolf-Hirschhorn syndrome candidate 1 (209053_s_at), score: -0.9 WISP1WNT1 inducible signaling pathway protein 1 (206796_at), score: 0.52 WNT2wingless-type MMTV integration site family member 2 (205648_at), score: 0.48 WRAP53WD repeat containing, antisense to TP53 (44563_at), score: -0.85 WWTR1WW domain containing transcription regulator 1 (202132_at), score: 0.46 YPEL5yippee-like 5 (Drosophila) (217783_s_at), score: 0.43 YRDCyrdC domain containing (E. coli) (218647_s_at), score: 0.55 ZNF35zinc finger protein 35 (206096_at), score: 0.5 ZNF672zinc finger protein 672 (218068_s_at), score: 0.44 ZNF85zinc finger protein 85 (206572_x_at), score: -0.76 ZWILCHZwilch, kinetochore associated, homolog (Drosophila) (218349_s_at), score: -0.82 ZWINTZW10 interactor (204026_s_at), score: -0.84

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
1Twin.CEL	1	2	DS-twin	hgu133plus2	Down	DS-twin 1
5CTwin.CEL	5	2	DS-twin	hgu133plus2	Down	DS-twin 5
6Twin.CEL	6	2	DS-twin	hgu133plus2	none	DS-twin 6
2Twin.CEL	2	2	DS-twin	hgu133plus2	none	DS-twin 2
ctrl a 08-03.CEL	1	1	DS-CC	hgu133a	none	DS-CC 1
E-GEOD-4219-raw-cel-1311956418.cel	13	7	Sph-mono	hgu133plus2	none	Sph-mon 1
E-TABM-263-raw-cel-1515485811.cel	9	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486291.cel	33	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486271.cel	32	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486351.cel	36	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486331.cel	35	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486231.cel	30	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515485851.cel	11	6	Cycle	hgu133a2	none	Cycle 1