Under-expression is coded with green,
over-expression with red color.
skeletal system development
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
cell adhesion
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
organ morphogenesis
Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
biological adhesion
The attachment of a cell or organism to a substrate or other organism.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
all
This term is the most general term possible
cell adhesion
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
organ morphogenesis
Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
proteinaceous extracellular matrix
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
extracellular matrix
A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants).
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
all
This term is the most general term possible
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
calcium ion binding
Interacting selectively with calcium ions (Ca2+).
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
signal transducer activity
Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.
receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
transmembrane receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
G-protein coupled receptor activity
A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
structural molecule activity
The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.
extracellular matrix structural constituent
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
binding
The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
metal ion binding
Interacting selectively with any metal ion.
ion binding
Interacting selectively with ions, charged atoms or groups of atoms.
cation binding
Interacting selectively with cations, charged atoms or groups of atoms with a net positive charge.
molecular transducer activity
The molecular function that accepts an input of one form and creates an output of a different form.
all
This term is the most general term possible
calcium ion binding
Interacting selectively with calcium ions (Ca2+).
ACANaggrecan (205679_x_at), score: -0.69 ANK3ankyrin 3, node of Ranvier (ankyrin G) (206385_s_at), score: -0.78 ANKRD1ankyrin repeat domain 1 (cardiac muscle) (206029_at), score: -0.76 AOX1aldehyde oxidase 1 (205083_at), score: -0.68 ARID5BAT rich interactive domain 5B (MRF1-like) (212614_at), score: -0.72 ARL4CADP-ribosylation factor-like 4C (202207_at), score: -0.72 AUTS2autism susceptibility candidate 2 (212599_at), score: 0.81 B3GALT2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 (217452_s_at), score: -0.74 BACE2beta-site APP-cleaving enzyme 2 (217867_x_at), score: 0.7 BST1bone marrow stromal cell antigen 1 (205715_at), score: -0.89 C1orf54chromosome 1 open reading frame 54 (219506_at), score: -0.85 C5orf23chromosome 5 open reading frame 23 (219054_at), score: 0.68 C7orf10chromosome 7 open reading frame 10 (219655_at), score: -0.77 CAMK2N1calcium/calmodulin-dependent protein kinase II inhibitor 1 (218309_at), score: 0.87 CAPGcapping protein (actin filament), gelsolin-like (201850_at), score: 0.72 CCDC81coiled-coil domain containing 81 (220389_at), score: -0.76 CCL2chemokine (C-C motif) ligand 2 (216598_s_at), score: -0.73 CCR10chemokine (C-C motif) receptor 10 (220565_at), score: -0.71 CDH4cadherin 4, type 1, R-cadherin (retinal) (220227_at), score: 0.68 CLEC3BC-type lectin domain family 3, member B (205200_at), score: -0.74 COBLL1COBL-like 1 (203642_s_at), score: -0.76 COL4A1collagen, type IV, alpha 1 (211981_at), score: -0.72 COL4A5collagen, type IV, alpha 5 (213110_s_at), score: -0.76 COMPcartilage oligomeric matrix protein (205713_s_at), score: 0.74 CTSCcathepsin C (201487_at), score: -0.77 CYFIP2cytoplasmic FMR1 interacting protein 2 (215785_s_at), score: -0.77 CYP1B1cytochrome P450, family 1, subfamily B, polypeptide 1 (202436_s_at), score: -0.71 DAAM2dishevelled associated activator of morphogenesis 2 (212793_at), score: -0.71 DMDdystrophin (203881_s_at), score: -0.8 EDIL3EGF-like repeats and discoidin I-like domains 3 (207379_at), score: -0.73 EMP2epithelial membrane protein 2 (204975_at), score: 0.67 EMX2empty spiracles homeobox 2 (221950_at), score: 0.64 ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 (205066_s_at), score: 0.85 EPHA5EPH receptor A5 (215664_s_at), score: -0.79 F2Rcoagulation factor II (thrombin) receptor (203989_x_at), score: -0.81 F3coagulation factor III (thromboplastin, tissue factor) (204363_at), score: 0.68 FHOD3formin homology 2 domain containing 3 (218980_at), score: 0.71 FOXE1forkhead box E1 (thyroid transcription factor 2) (206912_at), score: -0.74 FRMD4AFERM domain containing 4A (208476_s_at), score: -0.71 FSTfollistatin (204948_s_at), score: -0.81 FYCO1FYVE and coiled-coil domain containing 1 (218204_s_at), score: -0.7 FZD4frizzled homolog 4 (Drosophila) (218665_at), score: -0.75 GABBR2gamma-aminobutyric acid (GABA) B receptor, 2 (209990_s_at), score: 0.78 GALNT3UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) (203397_s_at), score: -0.72 GATA2GATA binding protein 2 (209710_at), score: 0.64 GATA6GATA binding protein 6 (210002_at), score: -0.68 GPERG protein-coupled estrogen receptor 1 (210640_s_at), score: 0.72 GPR116G protein-coupled receptor 116 (212950_at), score: -0.99 GREM2gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis) (220794_at), score: 0.67 HMOX1heme oxygenase (decycling) 1 (203665_at), score: 0.75 HNMThistamine N-methyltransferase (204112_s_at), score: -0.73 HOXB7homeobox B7 (204779_s_at), score: 0.76 HS3ST3A1heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 (219985_at), score: 0.92 ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (208937_s_at), score: 0.64 ISLRimmunoglobulin superfamily containing leucine-rich repeat (207191_s_at), score: 0.8 ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) (205032_at), score: 0.64 ITGA8integrin, alpha 8 (214265_at), score: -0.76 JAG1jagged 1 (Alagille syndrome) (216268_s_at), score: -0.95 KALRNkalirin, RhoGEF kinase (206078_at), score: -0.78 KCNE4potassium voltage-gated channel, Isk-related family, member 4 (222379_at), score: -0.79 KCNN4potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (204401_at), score: 0.74 KIAA0182KIAA0182 (212057_at), score: 0.64 KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (205051_s_at), score: -0.73 KLF9Kruppel-like factor 9 (203543_s_at), score: -0.8 KRT18keratin 18 (201596_x_at), score: -0.72 LGALS3BPlectin, galactoside-binding, soluble, 3 binding protein (200923_at), score: -0.81 LGR5leucine-rich repeat-containing G protein-coupled receptor 5 (213880_at), score: -0.76 LMO2LIM domain only 2 (rhombotin-like 1) (204249_s_at), score: -0.85 LPHN2latrophilin 2 (206953_s_at), score: -0.84 LPPR4plasticity related gene 1 (213496_at), score: -0.72 LPXNleupaxin (216250_s_at), score: 0.76 LRRC15leucine rich repeat containing 15 (213909_at), score: 0.89 LRRC17leucine rich repeat containing 17 (205381_at), score: -0.83 LRRC32leucine rich repeat containing 32 (203835_at), score: -0.79 MALLmal, T-cell differentiation protein-like (209373_at), score: 0.71 MANSC1MANSC domain containing 1 (220945_x_at), score: -0.67 MAP3K8mitogen-activated protein kinase kinase kinase 8 (205027_s_at), score: -0.75 MBPmyelin basic protein (210136_at), score: -1 MEOX2mesenchyme homeobox 2 (206201_s_at), score: -0.9 MESTmesoderm specific transcript homolog (mouse) (202016_at), score: -0.82 MEX3Dmex-3 homolog D (C. elegans) (91816_f_at), score: 0.63 MGPmatrix Gla protein (202291_s_at), score: -0.95 MMP14matrix metallopeptidase 14 (membrane-inserted) (202827_s_at), score: 0.63 MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (201069_at), score: 0.77 MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase) (205828_at), score: 0.66 MSX1msh homeobox 1 (205932_s_at), score: 0.78 MT1Mmetallothionein 1M (217546_at), score: 0.71 MYBL1v-myb myeloblastosis viral oncogene homolog (avian)-like 1 (213906_at), score: 0.65 MYCT1myc target 1 (220471_s_at), score: -0.73 NBL1neuroblastoma, suppression of tumorigenicity 1 (37005_at), score: 0.73 NCAM1neural cell adhesion molecule 1 (212843_at), score: 0.63 NDNnecdin homolog (mouse) (209550_at), score: 0.67 NDUFA4L2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (218484_at), score: -0.88 NEFMneurofilament, medium polypeptide (205113_at), score: -0.69 NET1neuroepithelial cell transforming 1 (201830_s_at), score: 0.8 NID2nidogen 2 (osteonidogen) (204114_at), score: -0.72 NKX3-1NK3 homeobox 1 (209706_at), score: 0.74 NOVnephroblastoma overexpressed gene (214321_at), score: -0.79 NPR3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) (219789_at), score: 0.67 NRG1neuregulin 1 (206343_s_at), score: 0.76 NRIP3nuclear receptor interacting protein 3 (219557_s_at), score: 0.64 NRXN3neurexin 3 (205795_at), score: -0.84 OLFM1olfactomedin 1 (213131_at), score: 0.65 PDCD4programmed cell death 4 (neoplastic transformation inhibitor) (202731_at), score: -0.68 PDE10Aphosphodiesterase 10A (205501_at), score: -0.69 PDE4Bphosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) (203708_at), score: 0.69 PDGFRLplatelet-derived growth factor receptor-like (205226_at), score: -0.68 PKIAprotein kinase (cAMP-dependent, catalytic) inhibitor alpha (204612_at), score: 0.63 PLA2G16phospholipase A2, group XVI (209581_at), score: -0.76 PLD1phospholipase D1, phosphatidylcholine-specific (215723_s_at), score: -0.72 PLXND1plexin D1 (38671_at), score: -0.72 PNMA2paraneoplastic antigen MA2 (209598_at), score: -0.89 POSTNperiostin, osteoblast specific factor (210809_s_at), score: -0.7 PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunit (218292_s_at), score: -0.8 PSG5pregnancy specific beta-1-glycoprotein 5 (204830_x_at), score: 0.65 PTGER4prostaglandin E receptor 4 (subtype EP4) (204897_at), score: -0.75 PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (204469_at), score: -0.93 PTX3pentraxin-related gene, rapidly induced by IL-1 beta (206157_at), score: -0.67 RAB15RAB15, member RAS onocogene family (221810_at), score: 0.66 RELNreelin (205923_at), score: -0.86 RGS7regulator of G-protein signaling 7 (206290_s_at), score: -0.72 RTN1reticulon 1 (203485_at), score: -0.77 S100A2S100 calcium binding protein A2 (204268_at), score: 0.65 SCN9Asodium channel, voltage-gated, type IX, alpha subunit (206950_at), score: -0.73 SDC1syndecan 1 (201287_s_at), score: 0.62 SFRP1secreted frizzled-related protein 1 (202036_s_at), score: 0.73 SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein) (213543_at), score: 0.69 SIX2SIX homeobox 2 (206510_at), score: -0.7 SLC1A4solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (209610_s_at), score: -0.68 SLC24A3solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 (57588_at), score: -0.8 SLC25A4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 (202825_at), score: -0.76 SLC7A11solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 (217678_at), score: -0.71 SLC7A8solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 (216092_s_at), score: 0.84 SLCO3A1solute carrier organic anion transporter family, member 3A1 (219229_at), score: 0.7 SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) (208608_s_at), score: -0.8 SOBPsine oculis binding protein homolog (Drosophila) (218974_at), score: -0.74 SOCS2suppressor of cytokine signaling 2 (203373_at), score: 0.65 SRGNserglycin (201859_at), score: -0.69 SSX2IPsynovial sarcoma, X breakpoint 2 interacting protein (203016_s_at), score: 0.76 STAT1signal transducer and activator of transcription 1, 91kDa (AFFX-HUMISGF3A/M97935_MA_at), score: -0.74 STAT4signal transducer and activator of transcription 4 (206118_at), score: -0.81 STEAP1six transmembrane epithelial antigen of the prostate 1 (205542_at), score: 0.65 STMN2stathmin-like 2 (203000_at), score: 0.79 TCF7L1transcription factor 7-like 1 (T-cell specific, HMG-box) (221016_s_at), score: -0.75 TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) (209676_at), score: -0.76 TINAGL1tubulointerstitial nephritis antigen-like 1 (219058_x_at), score: -0.89 TMEM158transmembrane protein 158 (213338_at), score: 0.92 TNXAtenascin XA pseudogene (213451_x_at), score: -0.97 TNXBtenascin XB (216333_x_at), score: -0.96 TRPV2transient receptor potential cation channel, subfamily V, member 2 (219282_s_at), score: -0.71 TUFT1tuftelin 1 (205807_s_at), score: -0.81 WWP2WW domain containing E3 ubiquitin protein ligase 2 (204022_at), score: -0.78 ZNF423zinc finger protein 423 (214761_at), score: -0.98 ZNF536zinc finger protein 536 (206403_at), score: 0.72
| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
|---|---|---|---|---|---|---|
| E-GEOD-3860-raw-cel-1561690336.cel | 9 | 5 | HGPS | hgu133a | HGPS | AG10750 |
| E-GEOD-3860-raw-cel-1561690231.cel | 4 | 5 | HGPS | hgu133a | HGPS | AG10750 |
| E-GEOD-3860-raw-cel-1561690432.cel | 16 | 5 | HGPS | hgu133a | HGPS | AG10750 |
| E-TABM-263-raw-cel-1515486271.cel | 32 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486331.cel | 35 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486291.cel | 33 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-GEOD-3860-raw-cel-1561690215.cel | 2 | 5 | HGPS | hgu133a | HGPS | AG11513 |
| E-GEOD-3860-raw-cel-1561690248.cel | 5 | 5 | HGPS | hgu133a | HGPS | AG11513 |
| E-GEOD-3860-raw-cel-1561690416.cel | 15 | 5 | HGPS | hgu133a | none | GM0316B |
| E-GEOD-3860-raw-cel-1561690304.cel | 8 | 5 | HGPS | hgu133a | none | GMO8398C |
| E-GEOD-3860-raw-cel-1561690360.cel | 12 | 5 | HGPS | hgu133a | none | GM0316B |
| E-GEOD-3860-raw-cel-1561690472.cel | 17 | 5 | HGPS | hgu133a | none | GM00038C |
| E-GEOD-3860-raw-cel-1561690344.cel | 10 | 5 | HGPS | hgu133a | none | GM00038C |
| E-GEOD-3860-raw-cel-1561690392.cel | 14 | 5 | HGPS | hgu133a | none | GMO8398C |
| E-GEOD-3860-raw-cel-1561690256.cel | 6 | 5 | HGPS | hgu133a | none | GMO8398C |
| E-GEOD-3860-raw-cel-1561690223.cel | 3 | 5 | HGPS | hgu133a | none | GM00038C |
