Under-expression is coded with green,
over-expression with red color.
system process
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
signal transduction
The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
cell communication
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
cell surface receptor linked signal transduction
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
G-protein coupled receptor protein signaling pathway
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
all
This term is the most general term possible
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
signal transduction
The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
intrinsic to membrane
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
all
This term is the most general term possible
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
peptide receptor activity
Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
signal transducer activity
Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.
receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
transmembrane receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
G-protein coupled receptor activity
A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
binding
The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
neuropeptide receptor activity
Combining with a neuropeptide to initiate a change in cell activity.
peptide receptor activity, G-protein coupled
Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
neurotransmitter receptor activity
Combining with a neurotransmitter to initiate a change in cell activity.
neurotransmitter binding
Interacting selectively with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
peptide binding
Interacting selectively with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.
neuropeptide binding
Interacting selectively and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).
molecular transducer activity
The molecular function that accepts an input of one form and creates an output of a different form.
all
This term is the most general term possible
neuropeptide receptor activity
Combining with a neuropeptide to initiate a change in cell activity.
peptide receptor activity
Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
neurotransmitter receptor activity
Combining with a neurotransmitter to initiate a change in cell activity.
neuropeptide receptor activity
Combining with a neuropeptide to initiate a change in cell activity.
peptide receptor activity, G-protein coupled
Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 04080 | 6.991e-03 | 0.7545 | 6 | 78 | Neuroactive ligand-receptor interaction |
A1CFAPOBEC1 complementation factor (220951_s_at), score: 0.77 ABCG4ATP-binding cassette, sub-family G (WHITE), member 4 (207593_at), score: 0.8 ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif, 7 (220705_s_at), score: 0.72 ADORA1adenosine A1 receptor (216220_s_at), score: 0.79 AFF2AF4/FMR2 family, member 2 (206105_at), score: 0.78 AIPL1aryl hydrocarbon receptor interacting protein-like 1 (219977_at), score: 0.71 AZGP1alpha-2-glycoprotein 1, zinc-binding (217014_s_at), score: 0.71 BRS3bombesin-like receptor 3 (207369_at), score: 0.75 BTNL3butyrophilin-like 3 (217207_s_at), score: 0.81 C10orf59chromosome 10 open reading frame 59 (220564_at), score: 0.71 C7orf28Achromosome 7 open reading frame 28A (201974_s_at), score: 0.95 C8orf60chromosome 8 open reading frame 60 (220712_at), score: 0.9 CA4carbonic anhydrase IV (206209_s_at), score: 0.85 CATSPER2cation channel, sperm associated 2 (217588_at), score: 0.81 CCDC9coiled-coil domain containing 9 (206257_at), score: 0.82 CD53CD53 molecule (203416_at), score: 0.79 CEACAM5carcinoembryonic antigen-related cell adhesion molecule 5 (201884_at), score: 0.72 CHN2chimerin (chimaerin) 2 (207486_x_at), score: 0.75 CHRNA6cholinergic receptor, nicotinic, alpha 6 (207568_at), score: 0.71 COL11A2collagen, type XI, alpha 2 (216993_s_at), score: 0.94 CTSFcathepsin F (203657_s_at), score: 0.8 CXCL10chemokine (C-X-C motif) ligand 10 (204533_at), score: 0.85 CXorf21chromosome X open reading frame 21 (220252_x_at), score: 0.85 CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 4 (205998_x_at), score: 0.93 DLX4distal-less homeobox 4 (208216_at), score: 0.73 DMBT1deleted in malignant brain tumors 1 (208250_s_at), score: 0.78 DNASE1L3deoxyribonuclease I-like 3 (205554_s_at), score: 0.78 DRD5dopamine receptor D5 (208486_at), score: 0.86 F11coagulation factor XI (206610_s_at), score: 0.81 FAM38Bfamily with sequence similarity 38, member B (219602_s_at), score: 0.77 FAM75A3family with sequence similarity 75, member A3 (215935_at), score: 0.8 FGL1fibrinogen-like 1 (205305_at), score: 0.83 FKSG2apoptosis inhibitor (208588_at), score: 0.71 FOLH1folate hydrolase (prostate-specific membrane antigen) 1 (217487_x_at), score: 0.78 GNG4guanine nucleotide binding protein (G protein), gamma 4 (205184_at), score: 0.79 GP1BAglycoprotein Ib (platelet), alpha polypeptide (207389_at), score: 0.74 GPATCH4G patch domain containing 4 (220596_at), score: 0.76 GZMMgranzyme M (lymphocyte met-ase 1) (207460_at), score: 0.75 HAB1B1 for mucin (215778_x_at), score: 0.89 HAND1heart and neural crest derivatives expressed 1 (220138_at), score: 0.8 HAO2hydroxyacid oxidase 2 (long chain) (220801_s_at), score: 0.86 HOXD4homeobox D4 (205522_at), score: 0.78 HS3ST2heparan sulfate (glucosamine) 3-O-sulfotransferase 2 (219697_at), score: 0.72 IGLL3immunoglobulin lambda-like polypeptide 3 (215946_x_at), score: 0.75 INE1inactivation escape 1 (non-protein coding) (207252_at), score: 0.77 LHX3LIM homeobox 3 (221670_s_at), score: 0.73 LILRA5leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 (215838_at), score: 0.71 LOC100188945cell division cycle associated 4 pseudogene (215109_at), score: 0.91 LOC149478hypothetical protein LOC149478 (215462_at), score: 0.78 LOC80054hypothetical LOC80054 (220465_at), score: 0.79 LOH3CR2Aloss of heterozygosity, 3, chromosomal region 2, gene A (220244_at), score: 0.79 LPAR4lysophosphatidic acid receptor 4 (206960_at), score: 0.71 LRRN2leucine rich repeat neuronal 2 (216164_at), score: 0.8 MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1 (213013_at), score: 0.72 MAPK8IP2mitogen-activated protein kinase 8 interacting protein 2 (205050_s_at), score: 0.72 MFNGMFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (204153_s_at), score: 0.8 MMRN2multimerin 2 (219091_s_at), score: 0.84 MOBPmyelin-associated oligodendrocyte basic protein (210193_at), score: 0.95 MSTP9macrophage stimulating, pseudogene 9 (213382_at), score: 0.78 MYL4myosin, light chain 4, alkali; atrial, embryonic (210088_x_at), score: 0.88 MYO1Amyosin IA (211916_s_at), score: 0.94 N4BP3Nedd4 binding protein 3 (214775_at), score: 0.82 NCRNA00092non-protein coding RNA 92 (215861_at), score: 0.85 NCRNA00093non-protein coding RNA 93 (210723_x_at), score: 0.82 NOTCH4Notch homolog 4 (Drosophila) (205247_at), score: 0.79 NPY2Rneuropeptide Y receptor Y2 (210730_s_at), score: 0.72 NRN1neuritin 1 (218625_at), score: 0.76 OR1E2olfactory receptor, family 1, subfamily E, member 2 (208587_s_at), score: 0.85 OR7E24olfactory receptor, family 7, subfamily E, member 24 (215463_at), score: 0.77 PCDH11Yprotocadherin 11 Y-linked (217049_x_at), score: 0.73 PECAM1platelet/endothelial cell adhesion molecule (208982_at), score: 0.75 PGCprogastricsin (pepsinogen C) (205261_at), score: 0.74 PGK2phosphoglycerate kinase 2 (217009_at), score: 0.74 PIPOXpipecolic acid oxidase (221605_s_at), score: 0.96 PRSS7protease, serine, 7 (enterokinase) (217269_s_at), score: 1 PYHIN1pyrin and HIN domain family, member 1 (216748_at), score: 0.97 ROS1c-ros oncogene 1 , receptor tyrosine kinase (207569_at), score: 0.7 RP3-377H14.5hypothetical LOC285830 (222279_at), score: 0.76 RP5-886K2.1neuronal thread protein AD7c-NTP (207953_at), score: 0.72 RPGRIP1retinitis pigmentosa GTPase regulator interacting protein 1 (206608_s_at), score: 0.88 RRHretinal pigment epithelium-derived rhodopsin homolog (208314_at), score: 0.7 S100A14S100 calcium binding protein A14 (218677_at), score: 0.93 SFTPBsurfactant protein B (214354_x_at), score: 0.77 SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (207185_at), score: 0.85 SLC15A1solute carrier family 15 (oligopeptide transporter), member 1 (211349_at), score: 0.76 SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 2 (208389_s_at), score: 0.74 SLC26A10solute carrier family 26, member 10 (214951_at), score: 0.88 SOCS3suppressor of cytokine signaling 3 (206359_at), score: 0.74 SPAG6sperm associated antigen 6 (210033_s_at), score: 0.72 ST8SIA3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 (208064_s_at), score: 0.77 TACR1tachykinin receptor 1 (208048_at), score: 0.85 TBX21T-box 21 (220684_at), score: 0.86 TBX6T-box 6 (207684_at), score: 0.78 TGM4transglutaminase 4 (prostate) (217566_s_at), score: 0.73 TMSB4Ythymosin beta 4, Y-linked (206769_at), score: 0.95 TRA@T cell receptor alpha locus (216540_at), score: 0.98 TSPY1testis specific protein, Y-linked 1 (216374_at), score: 0.79 VGFVGF nerve growth factor inducible (205586_x_at), score: 0.83
| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
|---|---|---|---|---|---|---|
| E-TABM-263-raw-cel-1515485651.cel | 1 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485951.cel | 16 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485711.cel | 4 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485831.cel | 10 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485871.cel | 12 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-GEOD-4219-raw-cel-1311956358.cel | 10 | 7 | Sph-mono | hgu133plus2 | none | Sph-mon 1 |
| E-TABM-263-raw-cel-1515486131.cel | 25 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485931.cel | 15 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| t21d 08-03.CEL | 7 | 1 | DS-CC | hgu133a | Down | DS-CC 7 |
| E-GEOD-3407-raw-cel-1437949557.cel | 1 | 4 | Cockayne | hgu133a | CS | eGFP |
| t21a 08-03.CEL | 4 | 1 | DS-CC | hgu133a | Down | DS-CC 4 |
| ctrl a 08-03.CEL | 1 | 1 | DS-CC | hgu133a | none | DS-CC 1 |
