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DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

cell cycle checkpoint

The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

mitotic cell cycle

Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.

M phase

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.

nuclear division

A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

regulation of protein amino acid phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

positive regulation of protein amino acid phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

cellular alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

DNA-dependent DNA replication

The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

DNA replication initiation

The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

transcription

The synthesis of either RNA on a template of DNA or DNA on a template of RNA.

transcription, DNA-dependent

The synthesis of RNA on a template of DNA.

regulation of transcription, DNA-dependent

Any process that modulates the frequency, rate or extent of DNA-dependent transcription.

regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

transcription from RNA polymerase II promoter

The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

protein amino acid phosphorylation

The process of introducing a phosphate group on to a protein.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

phosphorus metabolic process

The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).

phosphate metabolic process

The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.

cell motion

Any process involved in the controlled movement of a cell.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

organelle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

regulation of biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

positive regulation of biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

gene expression

The process by which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

positive regulation of macromolecule biosynthetic process

Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

positive regulation of phosphorus metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

positive regulation of macromolecule metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

positive regulation of gene expression

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

cellular component organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cellular component.

RNA metabolic process

The chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

phosphorylation

The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

cell migration

The orderly movement of cells from one site to another, often during the development of a multicellular organism or multicellular structure.

regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

regulation of phosphate metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

positive regulation of cellular biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

regulation of protein modification process

Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

RNA biosynthetic process

The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

locomotion

Self-propelled movement of a cell or organism from one location to another.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

regulation of phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

biopolymer modification

The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer, resulting in a change in its properties.

post-translational protein modification

The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

regulation of transcription

Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

positive regulation of transcription, DNA-dependent

Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription.

positive regulation of phosphate metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

positive regulation of transcription

Any process that activates or increases the frequency, rate or extent of transcription.

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase II promoter.

organelle fission

The creation of two or more organelles by division of one organelle.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of developmental process

Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of phosphorus metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.

regulation of RNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.

positive regulation of RNA metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA.

cell division

The process resulting in the physical partitioning and separation of a cell into daughter cells.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

interphase

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

interphase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

localization of cell

Any process by which a cell is transported to, and/or maintained in, a specific location.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

all

This term is the most general term possible

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of developmental process

Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

regulation of biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

positive regulation of macromolecule metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

cell motion

Any process involved in the controlled movement of a cell.

positive regulation of biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

positive regulation of macromolecule biosynthetic process

Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

positive regulation of cellular biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

positive regulation of macromolecule biosynthetic process

Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

positive regulation of cellular biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

positive regulation of macromolecule metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

positive regulation of gene expression

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

transcription

The synthesis of either RNA on a template of DNA or DNA on a template of RNA.

positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

positive regulation of phosphorus metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

regulation of phosphorus metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

positive regulation of macromolecule biosynthetic process

Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

positive regulation of cellular biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

regulation of transcription

Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

positive regulation of transcription

Any process that activates or increases the frequency, rate or extent of transcription.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

positive regulation of transcription

Any process that activates or increases the frequency, rate or extent of transcription.

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of transcription

Any process that activates or increases the frequency, rate or extent of transcription.

positive regulation of RNA metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA.

positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

regulation of transcription

Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

regulation of RNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of phosphorus metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

positive regulation of gene expression

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

regulation of transcription

Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.

positive regulation of RNA metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA.

transcription, DNA-dependent

The synthesis of RNA on a template of DNA.

regulation of transcription

Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

positive regulation of transcription

Any process that activates or increases the frequency, rate or extent of transcription.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

RNA metabolic process

The chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

RNA biosynthetic process

The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.

regulation of RNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.

positive regulation of RNA metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA.

regulation of phosphate metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

positive regulation of phosphate metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

interphase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

regulation of transcription, DNA-dependent

Any process that modulates the frequency, rate or extent of DNA-dependent transcription.

positive regulation of transcription

Any process that activates or increases the frequency, rate or extent of transcription.

positive regulation of transcription, DNA-dependent

Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription.

DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

transcription

The synthesis of either RNA on a template of DNA or DNA on a template of RNA.

regulation of transcription, DNA-dependent

Any process that modulates the frequency, rate or extent of DNA-dependent transcription.

positive regulation of transcription, DNA-dependent

Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription.

positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

positive regulation of phosphate metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

positive regulation of transcription, DNA-dependent

Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription.

regulation of protein modification process

Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

regulation of phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase II promoter.

positive regulation of protein amino acid phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

positive regulation of protein amino acid phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

regulation of protein amino acid phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase II promoter.

protein amino acid phosphorylation

The process of introducing a phosphate group on to a protein.

DNA replication initiation

The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

regulation of protein amino acid phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

positive regulation of protein amino acid phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

condensed chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosome, centromeric region

The region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

chromosome

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

all

This term is the most general term possible

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

protein binding

Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

receptor binding

Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

all

This term is the most general term possible

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022403	3.558e-08	9.149	33 AURKB, BIRC5, BLM, BUB1, BUB1B, C21orf45, CDC20, CDC6, CDC7, CDCA8, CDK2, CDKN1B, CDT1, CENPF, DDX11, DSN1, ERCC6L, IL1A, IL1B, INHBA, KIF11, KIF15, KIF22, MAD2L1, NDC80, NEDD9, POLA1, POLD1, PSMC3IP, RAD54B, TPX2, TTK, WEE1	285	cell cycle phase
GO:0008283	5.870e-08	17.94	48 AREG, BLM, BMP2, BMPR2, BNC1, BUB1, BUB1B, CCL2, CDC6, CDC7, CDK2, CDKN1B, CENPF, DDX11, DHCR7, FABP3, FGF1, FGF7, GINS1, HBEGF, HTR2A, IL11, IL1A, IL1B, IL6, IL8, INSIG1, JARID2, KIF15, LIF, MCM7, NAMPT, PDGFA, PDGFD, PDGFRB, POLA1, PPARD, PTGS2, PTHLH, SOX4, SOX9, TACSTD2, TGFBR1, TNFSF4, TPX2, TRIB1, TTK, VEGFA	559	cell proliferation
GO:0006260	7.709e-07	5.778	24 AREG, BLM, CDC6, CDC7, CDK2, CDT1, CHAF1A, DSCC1, DTL, GINS1, GINS2, GMNN, HMGB2, MCM10, MCM2, MCM5, MCM7, ORC6L, PDGFA, POLA1, POLD1, POLE2, PRIM1, RNASEH2A	180	DNA replication
GO:0000280	1.685e-06	5.554	23 AURKB, BIRC5, BUB1, BUB1B, C21orf45, CDC20, CDC6, CDCA8, CDK2, CENPF, DDX11, DSN1, ERCC6L, IL1A, IL1B, KIF11, KIF15, KIF22, MAD2L1, NDC80, NEDD9, TPX2, WEE1	173	nuclear division
GO:0007067	1.685e-06	5.554	23 AURKB, BIRC5, BUB1, BUB1B, C21orf45, CDC20, CDC6, CDCA8, CDK2, CENPF, DDX11, DSN1, ERCC6L, IL1A, IL1B, KIF11, KIF15, KIF22, MAD2L1, NDC80, NEDD9, TPX2, WEE1	173	mitosis
GO:0000087	2.304e-06	5.65	23 AURKB, BIRC5, BUB1, BUB1B, C21orf45, CDC20, CDC6, CDCA8, CDK2, CENPF, DDX11, DSN1, ERCC6L, IL1A, IL1B, KIF11, KIF15, KIF22, MAD2L1, NDC80, NEDD9, TPX2, WEE1	176	M phase of mitotic cell cycle
GO:0042127	2.567e-06	12.07	35 BLM, BMP2, BMPR2, BNC1, CCL2, CDC6, CDC7, CDK2, CDKN1B, DDX11, DHCR7, FABP3, FGF1, FGF7, HBEGF, HTR2A, IL11, IL1A, IL1B, IL6, IL8, JARID2, LIF, NAMPT, PDGFA, PDGFRB, PTGS2, PTHLH, SOX4, SOX9, TGFBR1, TNFSF4, TRIB1, TTK, VEGFA	376	regulation of cell proliferation
GO:0048285	3.125e-06	5.746	23 AURKB, BIRC5, BUB1, BUB1B, C21orf45, CDC20, CDC6, CDCA8, CDK2, CENPF, DDX11, DSN1, ERCC6L, IL1A, IL1B, KIF11, KIF15, KIF22, MAD2L1, NDC80, NEDD9, TPX2, WEE1	179	organelle fission
GO:0000278	4.503e-06	10.05	31 AURKB, BIRC5, BLM, BUB1, BUB1B, C21orf45, CDC20, CDC6, CDC7, CDCA8, CDK2, CDKN1B, CDT1, CENPF, DDX11, DSN1, ERCC6L, IL1A, IL1B, INHBA, KIF11, KIF15, KIF22, MAD2L1, NDC80, NEDD9, POLA1, POLD1, TPX2, TTK, WEE1	313	mitotic cell cycle
GO:0000279	4.823e-06	7.383	26 AURKB, BIRC5, BUB1, BUB1B, C21orf45, CDC20, CDC6, CDCA8, CDK2, CENPF, DDX11, DSN1, ERCC6L, IL1A, IL1B, KIF11, KIF15, KIF22, MAD2L1, NDC80, NEDD9, PSMC3IP, RAD54B, TPX2, TTK, WEE1	230	M phase
GO:0007049	5.290e-06	20.74	48 AURKB, BIRC5, BLM, BMP2, BUB1, BUB1B, C21orf45, CCNE2, CDC20, CDC6, CDC7, CDCA8, CDK2, CDKN1B, CDT1, CENPF, CHAF1A, CKAP2, DDX11, DSCC1, DSN1, ERCC6L, FANCG, GMNN, IL1A, IL1B, IL8, INHBA, KIF11, KIF15, KIF22, MAD2L1, MCM2, MCM7, MTSS1, NDC80, NEDD9, PLK3, POLA1, POLD1, PSMC3IP, RAD54B, RGS2, TP53BP2, TPX2, TTK, TXNIP, WEE1	646	cell cycle
GO:0008284	6.762e-06	6.003	23 BLM, BNC1, CCL2, CDC7, CDK2, DDX11, FGF1, FGF7, HBEGF, HTR2A, IL11, IL1B, IL6, LIF, NAMPT, PDGFA, PDGFRB, PTHLH, SOX4, TGFBR1, TNFSF4, TTK, VEGFA	187	positive regulation of cell proliferation
GO:0022402	2.072e-05	12.58	34 AURKB, BIRC5, BLM, BUB1, BUB1B, C21orf45, CDC20, CDC6, CDC7, CDCA8, CDK2, CDKN1B, CDT1, CENPF, DDX11, DSN1, ERCC6L, IL1A, IL1B, IL8, INHBA, KIF11, KIF15, KIF22, MAD2L1, NDC80, NEDD9, POLA1, POLD1, PSMC3IP, RAD54B, TPX2, TTK, WEE1	392	cell cycle process
GO:0016125	2.130e-05	2.054	13 C14orf1, CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, IDI2, INSIG1, LDLR, PPARD, SC4MOL, SQLE, SREBF2	64	sterol metabolic process
GO:0009611	4.703e-05	7.255	24 BMP2, BMP6, CCL2, CCL7, CHST2, CXCL3, F10, F3, FGF7, HBEGF, IL1A, IL1B, IL6, IL8, JMJD3, MAP2K3, NFKB1, PDGFA, PPARD, PTGS2, SRF, THBD, TICAM1, TNFAIP6	226	response to wounding
GO:0009605	1.046e-04	11.68	31 ADIPOR2, AQP3, BMP2, BMP6, CCL2, CCL7, CHST2, CXCL3, EGR2, F10, F3, FGF7, HBEGF, IL1A, IL1B, IL6, IL8, INHBA, ITGA1, JMJD3, MAP2K3, NFKB1, NR4A3, PDGFA, PPARD, PTGS2, SRF, THBD, TICAM1, TNFAIP6, VEGFA	364	response to external stimulus
GO:0016126	1.635e-04	1.091	9 C14orf1, CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, IDI2, SC4MOL, SQLE	34	sterol biosynthetic process
GO:0042325	1.648e-04	2.472	13 BMP2, CDKN1B, CLCF1, IL11, IL1B, IL6, INHBA, LIF, MCM7, PDGFD, PDGFRB, TGFBR1, TTK	77	regulation of phosphorylation
GO:0048518	1.822e-04	27.22	53 ANGPTL4, AQP3, AREG, BLM, BMP2, BMP6, BMPR2, BNC1, CCL2, CDC7, CDK2, CDKN1B, CLCF1, DDX11, EGR2, FEM1B, FGF1, FGF7, FOXO3, HBEGF, HTR2A, ICAM1, IL11, IL1A, IL1B, IL6, IL8, INHBA, KLF7, LIF, MAP2K3, NAMPT, NFKB1, NR4A1, NR4A3, PANX1, PDGFA, PDGFRB, PPARD, PPP3CC, PTHLH, REL, RUNX1, SOX4, SOX9, SRF, TGFBR1, TICAM1, TNFSF4, TP53BP2, TTK, VEGFA, WWTR1	848	positive regulation of biological process
GO:0006694	2.366e-04	1.798	11 BMP6, C14orf1, CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, IDI2, NR3C1, SC4MOL, SQLE	56	steroid biosynthetic process
GO:0019220	3.614e-04	2.664	13 BMP2, CDKN1B, CLCF1, IL11, IL1B, IL6, INHBA, LIF, MCM7, PDGFD, PDGFRB, TGFBR1, TTK	83	regulation of phosphate metabolic process
GO:0051174	3.614e-04	2.664	13 BMP2, CDKN1B, CLCF1, IL11, IL1B, IL6, INHBA, LIF, MCM7, PDGFD, PDGFRB, TGFBR1, TTK	83	regulation of phosphorus metabolic process
GO:0008202	3.986e-04	3.563	15 BMP6, C14orf1, CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, IDI2, INSIG1, LDLR, NR3C1, PPARD, SC4MOL, SQLE, SREBF2	111	steroid metabolic process
GO:0048522	5.320e-04	25.3	49 AREG, BLM, BMP2, BMP6, BMPR2, BNC1, CCL2, CDC7, CDK2, CDKN1B, CLCF1, DDX11, EGR2, FEM1B, FGF1, FGF7, FOXO3, HBEGF, HTR2A, ICAM1, IL11, IL1A, IL1B, IL6, INHBA, KLF7, LIF, MAP2K3, NAMPT, NFKB1, NR4A1, NR4A3, PDGFA, PDGFRB, PPARD, PPP3CC, PTHLH, REL, RUNX1, SOX4, SOX9, SRF, TGFBR1, TICAM1, TNFSF4, TP53BP2, TTK, VEGFA, WWTR1	788	positive regulation of cellular process
GO:0048513	7.350e-04	23.4	46 ANGPTL4, BLM, BMP2, BMP6, BMPR2, BNC1, CCL2, CENPF, CLCF1, COL15A1, DHCR7, EGR2, EGR3, FANCG, FGF1, FGF7, FOXO3, HBEGF, HMGCR, IL11, IL1A, IL1B, IL6, IL8, INHBA, JARID2, JMJD6, LAMC2, LIF, MAFF, NFKB1, NR3C1, NR4A3, PPARD, PPL, PRKG1, PTGS2, PTHLH, RELB, RUNX1, SOX4, SOX9, SPRY2, SRF, TGFBR1, VEGFA	729	organ development
GO:0000075	8.937e-04	1.701	10 BLM, BUB1, BUB1B, CCNE2, CDC6, CDT1, CENPF, FANCG, MAD2L1, TTK	53	cell cycle checkpoint
GO:0006259	1.042e-03	11.91	29 AREG, BLM, CDC6, CDC7, CDK2, CDT1, CHAF1A, DSCC1, DTL, FANCG, GINS1, GINS2, GMNN, HMGB2, MCM10, MCM2, MCM5, MCM7, ORC6L, PARP2, PDGFA, POLA1, POLD1, POLE2, PRIM1, PSMC3IP, RAD51AP1, RAD54B, RNASEH2A	371	DNA metabolic process
GO:0001932	1.204e-03	1.766	10 BMP2, CLCF1, IL11, IL1B, IL6, LIF, PDGFD, PDGFRB, TGFBR1, TTK	55	regulation of protein amino acid phosphorylation
GO:0001934	1.327e-03	1.091	8 BMP2, CLCF1, IL11, IL1B, IL6, LIF, TGFBR1, TTK	34	positive regulation of protein amino acid phosphorylation
GO:0008203	1.393e-03	1.798	10 CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, IDI2, INSIG1, LDLR, PPARD, SREBF2	56	cholesterol metabolic process
GO:0051301	1.651e-03	6.163	19 AURKB, BLM, BUB1, BUB1B, C21orf45, CCNE2, CDC20, CDC6, CDC7, CDCA8, CDK2, CENPF, DSN1, ERCC6L, KIF11, MAD2L1, NDC80, NEDD9, WEE1	192	cell division
GO:0051329	1.732e-03	2.247	11 BLM, CDC6, CDC7, CDK2, CDKN1B, CDT1, CENPF, DDX11, INHBA, POLA1, POLD1	70	interphase of mitotic cell cycle
GO:0010557	1.751e-03	9.117	24 AREG, BLM, BMP2, BMP6, EGR2, FOXO3, IL11, IL1A, IL1B, IL6, INHBA, KLF7, LIF, MAP2K3, NFKB1, NR4A1, NR4A3, PDGFA, RUNX1, SOX4, SOX9, SRF, TGFBR1, WWTR1	284	positive regulation of macromolecule biosynthetic process
GO:0002376	1.757e-03	14.96	33 AQP3, BLM, BMP6, CCL2, CCL7, CLCF1, CXCL3, FOXO3, GCH1, GEM, GPR183, ICAM1, IL11, IL1A, IL1B, IL1RL1, IL6, IL8, INHBA, ITGA1, JARID2, JMJD6, LIF, NDRG1, NFIL3, NFKB1, RELB, RUNX1, SOX4, TGFBR1, TICAM1, TNFSF4, VEGFA	466	immune system process
GO:0051325	2.442e-03	2.343	11 BLM, CDC6, CDC7, CDK2, CDKN1B, CDT1, CENPF, DDX11, INHBA, POLA1, POLD1	73	interphase
GO:0006954	2.930e-03	4.815	16 BMP2, BMP6, CCL2, CCL7, CHST2, CXCL3, IL1A, IL1B, IL6, IL8, JMJD3, MAP2K3, NFKB1, PTGS2, TICAM1, TNFAIP6	150	inflammatory response
GO:0031328	3.255e-03	9.534	24 AREG, BLM, BMP2, BMP6, EGR2, FOXO3, IL11, IL1A, IL1B, IL6, INHBA, KLF7, LIF, MAP2K3, NFKB1, NR4A1, NR4A3, PDGFA, RUNX1, SOX4, SOX9, SRF, TGFBR1, WWTR1	297	positive regulation of cellular biosynthetic process
GO:0016477	3.392e-03	5.425	17 CCL2, HBEGF, HMGCR, ICAM1, IL1B, IL6, IL8, ITGA1, PDGFA, PDGFRB, PPARD, PRKG1, SRF, TGFBR1, TRIB1, VCL, VEGFA	169	cell migration
GO:0006270	3.427e-03	0.642	6 CDC6, CDT1, MCM2, MCM5, MCM7, POLA1	20	DNA replication initiation
GO:0009891	3.566e-03	9.598	24 AREG, BLM, BMP2, BMP6, EGR2, FOXO3, IL11, IL1A, IL1B, IL6, INHBA, KLF7, LIF, MAP2K3, NFKB1, NR4A1, NR4A3, PDGFA, RUNX1, SOX4, SOX9, SRF, TGFBR1, WWTR1	299	positive regulation of biosynthetic process
GO:0050900	4.214e-03	0.963	7 CCL2, ICAM1, IL1B, IL6, IL8, ITGA1, VEGFA	30	leukocyte migration
GO:0042327	4.553e-03	1.316	8 BMP2, CLCF1, IL11, IL1B, IL6, LIF, TGFBR1, TTK	41	positive regulation of phosphorylation
GO:0045944	4.920e-03	4.526	15 BMP2, BMP6, EGR2, FOXO3, IL11, IL6, INHBA, LIF, NFKB1, NR4A1, NR4A3, RUNX1, SOX9, SRF, WWTR1	141	positive regulation of transcription from RNA polymerase II promoter
GO:0048870	4.933e-03	5.618	17 CCL2, HBEGF, HMGCR, ICAM1, IL1B, IL6, IL8, ITGA1, PDGFA, PDGFRB, PPARD, PRKG1, SRF, TGFBR1, TRIB1, VCL, VEGFA	175	cell motility
GO:0006950	4.951e-03	27.06	48 ANGPTL4, BLM, BMP2, BMP6, CCL2, CCL7, CHAF1A, CHST2, CXCL3, DTL, F10, F3, FANCG, FGF7, GCH1, HBEGF, HMGB2, HSPB3, HTR2A, IL1A, IL1B, IL1RL1, IL6, IL8, INHBA, JMJD3, MAFF, MAP2K3, MAP3K4, MCM7, NFKB1, PARP2, PDGFA, POLA1, POLD1, POLE2, PPARD, PTGS2, RAD51AP1, RAD54B, SGK1, SRF, THBD, TICAM1, TNFAIP6, TRIB1, TXNIP, VEGFA	843	response to stress
GO:0006066	5.027e-03	6.196	18 C14orf1, CYP51A1, DHCR7, GALNAC4S-6ST, GCH1, GFPT2, HK2, HMGCR, HMGCS1, IDI1, IDI2, INSIG1, LDLR, NR3C1, PPARD, SC4MOL, SQLE, SREBF2	193	cellular alcohol metabolic process
GO:0010604	5.426e-03	11.2	26 AREG, BLM, BMP2, BMP6, CLCF1, EGR2, FOXO3, IL11, IL1A, IL1B, IL6, INHBA, KLF7, LIF, MAP2K3, NFKB1, NR4A1, NR4A3, PDGFA, RUNX1, SOX4, SOX9, SRF, TGFBR1, TTK, WWTR1	349	positive regulation of macromolecule metabolic process
GO:0030154	5.640e-03	21.12	40 ANGPTL4, AQP3, BLM, BMP2, BMP6, BMPR2, CLCF1, COL15A1, DHCR7, EGR2, FANCG, FGF1, FOXO3, GNPTAB, HLX, IL11, IL6, INHBA, JMJD6, KLF7, LIF, MAFF, NDEL1, NFKB1, PPARD, PPL, PRKG1, PTHLH, RASGRP1, RELB, RUNX1, SLC2A14, SOX4, SOX9, SPRY2, SRF, TGFBR1, TXNIP, VEGFA, WWTR1	658	cell differentiation
GO:0045935	5.871e-03	8.699	22 AREG, BLM, BMP2, BMP6, EGR2, FOXO3, IL11, IL6, INHBA, KLF7, LIF, MAP2K3, NFKB1, NR4A1, NR4A3, PDGFA, RUNX1, SOX4, SOX9, SRF, TGFBR1, WWTR1	271	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0010562	6.063e-03	1.38	8 BMP2, CLCF1, IL11, IL1B, IL6, LIF, TGFBR1, TTK	43	positive regulation of phosphorus metabolic process
GO:0045937	6.063e-03	1.38	8 BMP2, CLCF1, IL11, IL1B, IL6, LIF, TGFBR1, TTK	43	positive regulation of phosphate metabolic process
GO:0031325	6.575e-03	11.36	26 AREG, BLM, BMP2, BMP6, CLCF1, EGR2, FOXO3, IL11, IL1A, IL1B, IL6, INHBA, KLF7, LIF, MAP2K3, NFKB1, NR4A1, NR4A3, PDGFA, RUNX1, SOX4, SOX9, SRF, TGFBR1, TTK, WWTR1	354	positive regulation of cellular metabolic process
GO:0045597	6.686e-03	2.664	11 BMP2, BMP6, BMPR2, FOXO3, IL6, INHBA, LIF, NFKB1, PPARD, RUNX1, SRF	83	positive regulation of cell differentiation
GO:0051320	7.804e-03	0.4815	5 CDC7, CDT1, DDX11, POLA1, POLD1	15	S phase
GO:0050794	7.996e-03	109.3	138 ADIPOR2, ANGPTL4, ANK2, AQP3, AREG, ASAP2, ATF3, BLM, BMP2, BMP6, BMPR2, BNC1, BUB1, BUB1B, CCL2, CCL7, CCNE2, CDC6, CDC7, CDK2, CDKN1B, CDT1, CDYL, CENPF, CHAF1A, CLCF1, CXCR7, DDX11, DEPDC1, DHCR7, EGR2, EGR3, EZH2, FABP3, FANCG, FEM1B, FGF1, FGF7, FOSB, FOXO3, FRY, GEM, GMNN, GPR183, HBEGF, HIPK3, HIVEP1, HLX, HMGB2, HOXA10, HTR2A, ICAM1, IER3, IL11, IL1A, IL1B, IL1RL1, IL6, IL8, INHBA, ITGA1, JARID2, JMJD3, JMJD6, KLF7, LIF, LMCD1, LRRFIP1, MAD2L1, MAFF, MAP2K3, MAP3K4, MCM2, MCM5, MCM7, MFAP4, MSC, MTSS1, NAMPT, NDC80, NEDD9, NFATC1, NFIL3, NFKB1, NR3C1, NR4A1, NR4A2, NR4A3, PANX1, PDGFA, PDGFD, PDGFRB, PIK3CD, PLCXD1, PLXNC1, PMEPA1, PPARD, PPP3CC, PRKG1, PTGS2, PTHLH, RAD54B, RASA2, RASGRP1, RASSF8, REL, RELB, RGS2, RICS, RRAD, RUNX1, SKIL, SOX4, SOX9, SPRED2, SPRY2, SPRY4, SPSB1, SREBF2, SRF, STK38L, TACSTD2, TGFBR1, TICAM1, TNFAIP3, TNFAIP6, TNFAIP8, TNFSF4, TP53BP2, TRIB1, TTK, TXNIP, VCL, VEGFA, WISP1, WWTR1, ZNF35, ZNF672	3404	regulation of cellular process
GO:0050896	8.528e-03	42.53	66 ADIPOR2, ANGPTL4, AQP3, BLM, BMP2, BMP6, CCL2, CCL7, CENPF, CHAF1A, CHST2, CXCL3, DTL, EGR2, F10, F3, FANCG, FGF7, FOSB, GCH1, GEM, GPR183, HBEGF, HMGB2, HSPB3, HTR2A, ICAM1, IL1A, IL1B, IL1RL1, IL6, IL8, INHBA, ITGA1, JMJD3, LIF, MAFF, MAP2K3, MAP3K4, MCM7, NDRG1, NFIL3, NFKB1, NR3C1, NR4A3, PANX1, PARP2, PDGFA, POLA1, POLD1, POLE2, PPARD, PTGS2, RAD51AP1, RAD54B, RELB, SGK1, SRF, TACSTD2, THBD, TICAM1, TNFAIP6, TNFSF4, TRIB1, TXNIP, VEGFA	1325	response to stimulus
GO:0032502	8.762e-03	60.03	86 ADIPOR2, ANGPTL4, AQP3, BIRC5, BLM, BMP2, BMP6, BMPR2, BNC1, BUB1B, CCL2, CDKN1B, CENPF, CHST2, CKAP2, CLCF1, COL15A1, CORIN, DHCR7, DRAM, EGR2, EGR3, FANCG, FEM1B, FGF1, FGF7, FOSB, FOXO3, GINS1, GNPTAB, HBEGF, HIPK3, HLX, HMGCR, HOXA10, HTR2A, IER3, IL11, IL1A, IL1B, IL6, IL8, INHBA, JARID2, JMJD6, KLF7, LAMC2, LIF, MAFF, MTSS1, NDEL1, NFKB1, NR3C1, NR4A1, NR4A3, PDGFA, PLXNC1, PPARD, PPL, PPP3CC, PRELP, PRKG1, PTGS2, PTHLH, RASGRP1, RELB, RUNX1, SGK1, SKIL, SLC2A14, SOX4, SOX9, SPRED2, SPRY2, SPRY4, SRF, TGFBR1, THBD, TICAM1, TNFAIP3, TNFAIP8, TP53BP2, TXNIP, VEGFA, WISP1, WWTR1	1870	developmental process
GO:0007346	9.448e-03	2.793	11 BLM, BUB1, BUB1B, CDC6, CDK2, CDT1, CENPF, IL1A, IL1B, MAD2L1, TTK	87	regulation of mitotic cell cycle
GO:0040011	9.548e-03	7.191	19 CCL2, CCL7, CXCL3, HBEGF, HMGCR, ICAM1, IL1B, IL6, IL8, ITGA1, PDGFA, PDGFRB, PPARD, PRKG1, SRF, TGFBR1, TRIB1, VCL, VEGFA	224	locomotion
GO:0009893	1.014e-02	11.75	26 AREG, BLM, BMP2, BMP6, CLCF1, EGR2, FOXO3, IL11, IL1A, IL1B, IL6, INHBA, KLF7, LIF, MAP2K3, NFKB1, NR4A1, NR4A3, PDGFA, RUNX1, SOX4, SOX9, SRF, TGFBR1, TTK, WWTR1	366	positive regulation of metabolic process
GO:0065007	1.019e-02	119	147 ADIPOR2, ANGPTL4, ANK2, AQP3, AREG, ASAP2, ATF3, BLM, BMP2, BMP6, BMPR2, BNC1, BUB1, BUB1B, CCL2, CCL7, CCNE2, CDC20, CDC6, CDC7, CDK2, CDKN1B, CDT1, CDYL, CENPF, CHAF1A, CLCF1, CORIN, CXCR7, DDX11, DEPDC1, DHCR7, EGR2, EGR3, EZH2, F10, F3, FABP3, FANCG, FEM1B, FGF1, FGF7, FOSB, FOXO3, FRY, GCH1, GEM, GMNN, GPR183, HBEGF, HIPK3, HIVEP1, HLX, HMGB2, HOXA10, HTR2A, ICAM1, IER3, IL11, IL1A, IL1B, IL1RL1, IL6, IL8, INHBA, ITGA1, JARID2, JMJD3, JMJD6, KLF7, LDLR, LIF, LMCD1, LRRFIP1, MAD2L1, MAFF, MAP2K3, MAP3K4, MCM2, MCM5, MCM7, MFAP4, MSC, MTSS1, NAMPT, NDC80, NEDD9, NFATC1, NFIL3, NFKB1, NR3C1, NR4A1, NR4A2, NR4A3, PANX1, PCSK7, PDGFA, PDGFD, PDGFRB, PIK3CD, PLCXD1, PLXNC1, PMEPA1, PPARD, PPP3CC, PRKG1, PTGS2, PTHLH, RAD54B, RASA2, RASGRP1, RASSF8, REL, RELB, RGS2, RICS, RRAD, RUNX1, SKIL, SOX4, SOX9, SPRED2, SPRY2, SPRY4, SPSB1, SREBF2, SRF, STK38L, TACSTD2, TGFBR1, THBD, TICAM1, TNFAIP3, TNFAIP6, TNFAIP8, TNFSF4, TP53BP2, TRIB1, TRPC6, TTK, TXNIP, VCL, VEGFA, WISP1, WWTR1, ZNF35, ZNF672	3707	biological regulation
GO:0031401	1.022e-02	1.509	8 BMP2, CLCF1, IL11, IL1B, IL6, LIF, TGFBR1, TTK	47	positive regulation of protein modification process
GO:0006695	1.040e-02	0.8025	6 CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, IDI2	25	cholesterol biosynthetic process
GO:0006928	1.056e-02	8.507	21 CCL2, EGR2, HBEGF, HMGCR, ICAM1, IL1B, IL6, IL8, ITGA1, KLF7, MTSS1, PDGFA, PDGFRB, PPARD, PRKG1, PTGS2, SRF, TGFBR1, TRIB1, VCL, VEGFA	265	cell motion
GO:0051674	1.056e-02	8.507	21 CCL2, EGR2, HBEGF, HMGCR, ICAM1, IL1B, IL6, IL8, ITGA1, KLF7, MTSS1, PDGFA, PDGFRB, PPARD, PRKG1, PTGS2, SRF, TGFBR1, TRIB1, VCL, VEGFA	265	localization of cell
GO:0046888	1.084e-02	0.2889	4 IL11, IL1B, INHBA, LIF	9	negative regulation of hormone secretion
GO:0006261	1.155e-02	1.958	9 CDC6, CDT1, HMGB2, MCM2, MCM5, MCM7, POLA1, POLE2, PRIM1	61	DNA-dependent DNA replication
GO:0033135	1.172e-02	0.1284	3 IL11, IL6, LIF	4	regulation of peptidyl-serine phosphorylation
GO:0033138	1.172e-02	0.1284	3 IL11, IL6, LIF	4	positive regulation of peptidyl-serine phosphorylation
GO:0050730	1.241e-02	0.8346	6 CLCF1, IL11, IL6, LIF, PDGFD, PDGFRB	26	regulation of peptidyl-tyrosine phosphorylation
GO:0008544	1.275e-02	1.99	9 BNC1, FGF7, LAMC2, MAFF, PPARD, PPL, PTGS2, PTHLH, SOX9	62	epidermis development
GO:0045941	1.276e-02	8.025	20 BLM, BMP2, BMP6, EGR2, FOXO3, IL11, IL6, INHBA, KLF7, LIF, MAP2K3, NFKB1, NR4A1, NR4A3, RUNX1, SOX4, SOX9, SRF, TGFBR1, WWTR1	250	positive regulation of transcription
GO:0002237	1.306e-02	0.5457	5 GCH1, IL1B, IL6, THBD, TRIB1	17	response to molecule of bacterial origin
GO:0030595	1.306e-02	0.5457	5 CCL2, IL1B, IL6, IL8, ITGA1	17	leukocyte chemotaxis
GO:0060326	1.306e-02	0.5457	5 CCL2, IL1B, IL6, IL8, ITGA1	17	cell chemotaxis
GO:0044249	1.328e-02	73.74	100 AREG, ATF3, B3GNT2, BLM, BMP2, BMP6, BMPR2, BNC1, C14orf1, CDC6, CDC7, CDK2, CDT1, CDYL, CENPF, CHAF1A, CYP51A1, DHCR7, DSCC1, DTL, EGR2, EGR3, EZH2, FABP3, FOSB, FOXO3, FRY, GALNAC4S-6ST, GCH1, GINS1, GINS2, GMNN, HIPK3, HIVEP1, HIVEP2, HLX, HMGB2, HMGCR, HMGCS1, HOXA10, IDI1, IDI2, IL11, IL1A, IL1B, IL6, INHBA, INSIG1, JARID2, JMJD3, KLF7, LDLR, LIF, LMCD1, LRRFIP1, MAFF, MAP2K3, MCM10, MCM2, MCM5, MCM7, MSC, NAMPT, NFATC1, NFIL3, NFKB1, NR3C1, NR4A1, NR4A2, NR4A3, ORC6L, PANK3, PDGFA, POLA1, POLD1, POLE2, PPARD, PRIM1, PTGS2, PTHLH, RAD54B, REL, RELB, RNASEH2A, RUNX1, SC4MOL, SCD, SKIL, SOX4, SOX9, SQLE, SREBF2, SRF, ST3GAL1, TGFBR1, TRIB1, TXNIP, WWTR1, ZNF35, ZNF672	2297	cellular biosynthetic process
GO:0031399	1.384e-02	2.472	10 BMP2, CLCF1, IL11, IL1B, IL6, LIF, PDGFD, PDGFRB, TGFBR1, TTK	77	regulation of protein modification process
GO:0045893	1.428e-02	6.87	18 BMP2, BMP6, EGR2, FOXO3, IL11, IL6, INHBA, KLF7, LIF, MAP2K3, NFKB1, NR4A1, NR4A3, RUNX1, SOX4, SOX9, SRF, WWTR1	214	positive regulation of transcription, DNA-dependent
GO:0001649	1.473e-02	0.8667	6 BMP2, BMP6, BMPR2, IL6, PTHLH, WWTR1	27	osteoblast differentiation
GO:0009058	1.507e-02	74.96	101 AREG, ATF3, B3GNT2, BLM, BMP2, BMP6, BMPR2, BNC1, C14orf1, CDC6, CDC7, CDK2, CDT1, CDYL, CENPF, CHAF1A, CYP51A1, DHCR7, DSCC1, DTL, EGR2, EGR3, EZH2, FABP3, FOSB, FOXO3, FRY, GALNAC4S-6ST, GCH1, GFPT2, GINS1, GINS2, GMNN, HIPK3, HIVEP1, HIVEP2, HLX, HMGB2, HMGCR, HMGCS1, HOXA10, IDI1, IDI2, IL11, IL1A, IL1B, IL6, INHBA, INSIG1, JARID2, JMJD3, KLF7, LDLR, LIF, LMCD1, LRRFIP1, MAFF, MAP2K3, MCM10, MCM2, MCM5, MCM7, MSC, NAMPT, NFATC1, NFIL3, NFKB1, NR3C1, NR4A1, NR4A2, NR4A3, ORC6L, PANK3, PDGFA, POLA1, POLD1, POLE2, PPARD, PRIM1, PTGS2, PTHLH, RAD54B, REL, RELB, RNASEH2A, RUNX1, SC4MOL, SCD, SKIL, SOX4, SOX9, SQLE, SREBF2, SRF, ST3GAL1, TGFBR1, TRIB1, TXNIP, WWTR1, ZNF35, ZNF672	2335	biosynthetic process
GO:0051254	1.560e-02	6.934	18 BMP2, BMP6, EGR2, FOXO3, IL11, IL6, INHBA, KLF7, LIF, MAP2K3, NFKB1, NR4A1, NR4A3, RUNX1, SOX4, SOX9, SRF, WWTR1	216	positive regulation of RNA metabolic process
GO:0010628	1.631e-02	8.218	20 BLM, BMP2, BMP6, EGR2, FOXO3, IL11, IL6, INHBA, KLF7, LIF, MAP2K3, NFKB1, NR4A1, NR4A3, RUNX1, SOX4, SOX9, SRF, TGFBR1, WWTR1	256	positive regulation of gene expression
GO:0018105	1.638e-02	0.5778	5 HIPK3, IL11, IL6, LIF, TGFBR1	18	peptidyl-serine phosphorylation
GO:0007275	1.645e-02	40.35	62 ANGPTL4, BLM, BMP2, BMP6, BMPR2, BNC1, CCL2, CENPF, CHST2, CLCF1, COL15A1, DHCR7, EGR2, EGR3, FANCG, FGF1, FGF7, FOSB, FOXO3, GINS1, HBEGF, HLX, HMGCR, HOXA10, IL11, IL1A, IL1B, IL6, IL8, INHBA, JARID2, JMJD6, KLF7, LAMC2, LIF, MAFF, NDEL1, NFKB1, NR3C1, NR4A3, PDGFA, PLXNC1, PPARD, PPL, PRELP, PRKG1, PTGS2, PTHLH, RELB, RUNX1, SKIL, SLC2A14, SOX4, SOX9, SPRED2, SPRY2, SPRY4, SRF, TGFBR1, THBD, VEGFA, WWTR1	1257	multicellular organismal development
GO:0051726	1.689e-02	8.25	20 BLM, BMP2, BUB1, BUB1B, CCNE2, CDC6, CDC7, CDK2, CDKN1B, CDT1, CENPF, FANCG, GMNN, IL1A, IL1B, INHBA, MAD2L1, MTSS1, TP53BP2, TTK	257	regulation of cell cycle
GO:0032501	1.758e-02	51.71	75 ANGPTL4, AQP3, BLM, BMP2, BMP6, BMPR2, BNC1, CCL2, CENPF, CHST2, CLCF1, COL15A1, CORIN, DHCR7, EGR2, EGR3, F10, F3, FANCG, FGF1, FGF7, FOSB, FOXO3, GCH1, GINS1, HBEGF, HK2, HLX, HMGCR, HOXA10, HTR2A, IL11, IL1A, IL1B, IL6, IL8, INHBA, JARID2, JMJD6, KLF7, LAMC2, LDLR, LIF, MAFF, MAP2K3, NDEL1, NFKB1, NR3C1, NR4A3, PANX1, PDGFA, PLXNC1, PPARD, PPL, PRELP, PRKG1, PTGS2, PTHLH, RELB, RUNX1, SKIL, SLC19A2, SLC2A14, SOX4, SOX9, SPRED2, SPRY2, SPRY4, SRF, STBD1, TACSTD2, TGFBR1, THBD, VEGFA, WWTR1	1611	multicellular organismal process
GO:0006275	1.902e-02	1.284	7 AREG, BLM, CDC6, CDK2, CDT1, GMNN, PDGFA	40	regulation of DNA replication
GO:0048869	1.948e-02	25.87	44 ADIPOR2, ANGPTL4, AQP3, BLM, BMP2, BMP6, BMPR2, CDKN1B, CLCF1, COL15A1, DHCR7, EGR2, FANCG, FGF1, FOXO3, GNPTAB, HLX, IL11, IL6, INHBA, JMJD6, KLF7, LIF, MAFF, MTSS1, NDEL1, NFKB1, PPARD, PPL, PRKG1, PTHLH, RASGRP1, RELB, RUNX1, SLC2A14, SOX4, SOX9, SPRY2, SRF, TGFBR1, TXNIP, VEGFA, WISP1, WWTR1	806	cellular developmental process
GO:0006935	2.011e-02	2.151	9 CCL2, CCL7, CXCL3, IL1B, IL6, IL8, ITGA1, PDGFA, VEGFA	67	chemotaxis
GO:0042330	2.011e-02	2.151	9 CCL2, CCL7, CXCL3, IL1B, IL6, IL8, ITGA1, PDGFA, VEGFA	67	taxis
GO:0007093	2.015e-02	0.9309	6 BLM, BUB1, BUB1B, CENPF, MAD2L1, TTK	29	mitotic cell cycle checkpoint
GO:0048523	2.046e-02	27.54	46 ADIPOR2, ANGPTL4, BLM, BMP2, BUB1B, CCL2, CDC6, CDKN1B, CDT1, CENPF, CLCF1, FABP3, FOSB, GMNN, HIPK3, HMGB2, HTR2A, IER3, IL11, IL1A, IL1B, IL1RL1, IL6, IL8, INHBA, JARID2, JMJD3, LIF, LMCD1, LRRFIP1, MTSS1, NFKB1, PDGFA, PTGS2, PTHLH, RGS2, SOX4, SOX9, TGFBR1, TNFAIP3, TNFAIP8, TP53BP2, TRIB1, VCL, VEGFA, WWTR1	858	negative regulation of cellular process
GO:0007094	2.285e-02	0.1605	3 BUB1, CENPF, TTK	5	mitotic cell cycle spindle assembly checkpoint
GO:0031577	2.285e-02	0.1605	3 BUB1, CENPF, TTK	5	spindle checkpoint
GO:0007167	2.552e-02	7.319	18 AREG, BMP2, BMP6, BMPR2, CCL2, FGF1, FGF7, HBEGF, IL1B, INHBA, LIF, MTSS1, PDGFA, PDGFRB, RGS2, TGFBR1, TTK, VEGFA	228	enzyme linked receptor protein signaling pathway
GO:0007398	2.562e-02	2.247	9 BNC1, FGF7, LAMC2, MAFF, PPARD, PPL, PTGS2, PTHLH, SOX9	70	ectoderm development
GO:0051272	2.667e-02	1.38	7 HBEGF, ICAM1, IL6, PDGFA, PDGFRB, TGFBR1, VEGFA	43	positive regulation of cell motion
GO:0006366	2.755e-02	15.67	30 BMP2, BMP6, BMPR2, EGR2, FOSB, FOXO3, HMGB2, IL11, IL6, INHBA, JARID2, JMJD3, KLF7, LIF, LMCD1, LRRFIP1, MAFF, MSC, NFATC1, NFIL3, NFKB1, NR3C1, NR4A1, NR4A3, RUNX1, SKIL, SOX9, SREBF2, SRF, WWTR1	488	transcription from RNA polymerase II promoter
GO:0032879	2.828e-02	6.773	17 HBEGF, HTR2A, ICAM1, IL11, IL1A, IL1B, IL6, INHBA, LIF, NFKB1, PANX1, PDGFA, PDGFRB, TGFBR1, TRIB1, VCL, VEGFA	211	regulation of localization
GO:0000084	2.831e-02	0.3852	4 CDT1, DDX11, POLA1, POLD1	12	S phase of mitotic cell cycle
GO:0051046	2.862e-02	1.83	8 HTR2A, IL11, IL1A, IL1B, IL6, INHBA, LIF, PANX1	57	regulation of secretion
GO:0051239	2.863e-02	10.05	22 ANGPTL4, BMP2, BMP6, BMPR2, CENPF, EGR2, FOXO3, HBEGF, HTR2A, IL1A, IL1B, IL6, INHBA, LIF, MAFF, MAP2K3, NFKB1, PANX1, PDGFA, PTHLH, RUNX1, SRF	313	regulation of multicellular organismal process
GO:0018209	2.918e-02	0.6741	5 HIPK3, IL11, IL6, LIF, TGFBR1	21	peptidyl-serine modification
GO:0045639	2.918e-02	0.6741	5 FOXO3, INHBA, LIF, NFKB1, RUNX1	21	positive regulation of myeloid cell differentiation
GO:0050789	3.176e-02	112.9	138 ADIPOR2, ANGPTL4, ANK2, AQP3, AREG, ASAP2, ATF3, BLM, BMP2, BMP6, BMPR2, BNC1, BUB1, BUB1B, CCL2, CCL7, CCNE2, CDC6, CDC7, CDK2, CDKN1B, CDT1, CDYL, CENPF, CHAF1A, CLCF1, CXCR7, DDX11, DEPDC1, DHCR7, EGR2, EGR3, EZH2, FABP3, FANCG, FEM1B, FGF1, FGF7, FOSB, FOXO3, FRY, GEM, GMNN, GPR183, HBEGF, HIPK3, HIVEP1, HLX, HMGB2, HOXA10, HTR2A, ICAM1, IER3, IL11, IL1A, IL1B, IL1RL1, IL6, IL8, INHBA, ITGA1, JARID2, JMJD3, JMJD6, KLF7, LIF, LMCD1, LRRFIP1, MAD2L1, MAFF, MAP2K3, MAP3K4, MCM2, MCM5, MCM7, MFAP4, MSC, MTSS1, NAMPT, NDC80, NEDD9, NFATC1, NFIL3, NFKB1, NR3C1, NR4A1, NR4A2, NR4A3, PANX1, PDGFA, PDGFD, PDGFRB, PIK3CD, PLCXD1, PLXNC1, PMEPA1, PPARD, PPP3CC, PRKG1, PTGS2, PTHLH, RAD54B, RASA2, RASGRP1, RASSF8, REL, RELB, RGS2, RICS, RRAD, RUNX1, SKIL, SOX4, SOX9, SPRED2, SPRY2, SPRY4, SPSB1, SREBF2, SRF, STK38L, TACSTD2, TGFBR1, TICAM1, TNFAIP3, TNFAIP6, TNFAIP8, TNFSF4, TP53BP2, TRIB1, TTK, TXNIP, VCL, VEGFA, WISP1, WWTR1, ZNF35, ZNF672	3518	regulation of biological process
GO:0007267	3.271e-02	8.186	19 AREG, BMP2, CCL7, EGR2, EGR3, FGF1, HTR2A, IL11, IL1B, IL6, IL8, INHBA, LIF, NAMPT, PDGFA, PTHLH, SPRY2, TNFAIP6, WISP1	255	cell-cell signaling
GO:0048519	3.343e-02	29.21	47 ADIPOR2, ANGPTL4, BLM, BMP2, BMPR2, BUB1B, CCL2, CDC6, CDKN1B, CDT1, CENPF, CLCF1, FABP3, FOSB, GMNN, HIPK3, HMGB2, HTR2A, IER3, IL11, IL1A, IL1B, IL1RL1, IL6, IL8, INHBA, JARID2, JMJD3, LIF, LMCD1, LRRFIP1, MTSS1, NFKB1, PDGFA, PTGS2, PTHLH, RGS2, SOX4, SOX9, TGFBR1, TNFAIP3, TNFAIP8, TP53BP2, TRIB1, VCL, VEGFA, WWTR1	910	negative regulation of biological process
GO:0007165	3.347e-02	56.75	79 ADIPOR2, ANGPTL4, ANK2, AREG, ASAP2, BLM, BMP2, BMP6, BMPR2, BUB1B, CCL2, CCL7, CLCF1, CXCR7, DEPDC1, FGF1, FGF7, GEM, GPR183, HBEGF, HMGB2, HTR2A, IL11, IL1A, IL1B, IL1RL1, IL6, IL8, INHBA, ITGA1, JMJD6, LIF, MAP2K3, MAP3K4, MFAP4, MTSS1, NAMPT, NDC80, NEDD9, NFATC1, NFKB1, NR3C1, NR4A1, NR4A2, PDGFA, PDGFRB, PIK3CD, PLCXD1, PLXNC1, PMEPA1, PPARD, PPP3CC, PRKG1, PTHLH, RASA2, RASGRP1, RASSF8, REL, RGS2, RICS, RRAD, SKIL, SOX4, SPRED2, SPRY2, SPRY4, SPSB1, STK38L, TACSTD2, TGFBR1, TICAM1, TNFAIP3, TNFAIP6, TNFSF4, TP53BP2, TRIB1, TTK, VEGFA, WISP1	1768	signal transduction
GO:0048731	3.361e-02	31.68	50 ANGPTL4, BLM, BMP2, BMP6, BMPR2, BNC1, CCL2, CENPF, CLCF1, COL15A1, DHCR7, EGR2, EGR3, FANCG, FGF1, FGF7, FOXO3, HBEGF, HMGCR, IL11, IL1A, IL1B, IL6, IL8, INHBA, JARID2, JMJD6, KLF7, LAMC2, LIF, MAFF, NDEL1, NFKB1, NR3C1, NR4A3, PPARD, PPL, PRELP, PRKG1, PTGS2, PTHLH, RELB, RUNX1, SOX4, SOX9, SPRY2, SRF, TGFBR1, VEGFA, WWTR1	987	system development
GO:0006468	3.394e-02	13.03	26 AURKB, BMP2, BMPR2, BUB1, CCL2, CDC7, CDK2, CLCF1, HIPK3, IL11, IL1B, IL6, LIF, MAP2K3, MAP3K4, PDGFD, PDGFRB, PIK3CD, PLK3, PRKG1, SGK1, STK38L, TGFBR1, TRIB1, TTK, WEE1	406	protein amino acid phosphorylation
GO:0045595	3.491e-02	5.714	15 AQP3, BMP2, BMP6, BMPR2, FOXO3, IL6, INHBA, LIF, MAFF, NFKB1, PPARD, PTHLH, RUNX1, SRF, WWTR1	178	regulation of cell differentiation
GO:0006952	3.491e-02	8.25	19 BMP2, BMP6, CCL2, CCL7, CHST2, CXCL3, GCH1, IL1A, IL1B, IL1RL1, IL6, IL8, INHBA, JMJD3, MAP2K3, NFKB1, PTGS2, TICAM1, TNFAIP6	257	defense response
GO:0008299	3.576e-02	0.4173	4 HMGCR, HMGCS1, IDI1, IDI2	13	isoprenoid biosynthetic process
GO:0010573	3.653e-02	0.1926	3 IL1A, IL1B, IL6	6	vascular endothelial growth factor production
GO:0010574	3.653e-02	0.1926	3 IL1A, IL1B, IL6	6	regulation of vascular endothelial growth factor production
GO:0048008	3.653e-02	0.1926	3 PDGFA, PDGFRB, VEGFA	6	platelet-derived growth factor receptor signaling pathway
GO:0010646	3.939e-02	13.23	26 ASAP2, BMP2, CLCF1, EGR2, HTR2A, IL11, IL1B, IL1RL1, IL6, INHBA, LIF, PPARD, RASA2, RASGRP1, REL, RGS2, SOX4, SPRED2, SPRY2, SPRY4, TGFBR1, TICAM1, TNFAIP3, TRIB1, TTK, VEGFA	412	regulation of cell communication
GO:0009966	4.286e-02	11.91	24 ASAP2, BMP2, CLCF1, IL11, IL1B, IL1RL1, IL6, INHBA, LIF, PPARD, RASA2, RASGRP1, REL, RGS2, SOX4, SPRED2, SPRY2, SPRY4, TGFBR1, TICAM1, TNFAIP3, TRIB1, TTK, VEGFA	371	regulation of signal transduction
GO:0032496	4.392e-02	0.4494	4 GCH1, IL1B, THBD, TRIB1	14	response to lipopolysaccharide
GO:0045669	4.392e-02	0.4494	4 BMP2, BMP6, BMPR2, IL6	14	positive regulation of osteoblast differentiation
GO:0007154	4.605e-02	61.25	83 ADIPOR2, ANGPTL4, ANK2, AREG, ASAP2, BLM, BMP2, BMP6, BMPR2, BUB1B, C6orf145, CCL2, CCL7, CLCF1, CXCR7, DEPDC1, EGR2, EGR3, FGF1, FGF7, GEM, GPR183, HBEGF, HMGB2, HTR2A, IL11, IL1A, IL1B, IL1RL1, IL6, IL8, INHBA, ITGA1, JMJD6, LIF, MAP2K3, MAP3K4, MFAP4, MTSS1, NAMPT, NDC80, NEDD9, NFATC1, NFKB1, NR3C1, NR4A1, NR4A2, PDGFA, PDGFRB, PIK3CD, PLCXD1, PLXNC1, PMEPA1, PPARD, PPP3CC, PRKG1, PTHLH, RASA2, RASGRP1, RASSF8, REL, RGS2, RICS, RRAD, SKIL, SOX4, SPRED2, SPRY2, SPRY4, SPSB1, STK38L, TACSTD2, TGFBR1, TICAM1, TNFAIP3, TNFAIP6, TNFSF4, TP53BP2, TRIB1, TTK, VEGFA, WISP1, ZCCHC2	1908	cell communication
GO:0009888	4.719e-02	4.751	13 BMP2, BMP6, BMPR2, BNC1, FGF7, LAMC2, MAFF, NR4A3, PPARD, PPL, PTGS2, PTHLH, SOX9	148	tissue development
GO:0002521	4.924e-02	3.082	10 BLM, CLCF1, IL11, INHBA, JMJD6, LIF, NFKB1, RELB, RUNX1, SOX4	96	leukocyte differentiation

Id	Pvalue	ExpCount	Count	Size	Term
GO:0000775	3.016e-05	1.967	12 AURKB, BUB1, BUB1B, C21orf45, CDCA8, CENPF, CENPM, DSN1, ERCC6L, KIF22, MAD2L1, NDC80	63	chromosome, centromeric region
GO:0005819	6.279e-05	2.498	13 AURKB, BUB1, BUB1B, CDC20, CDC6, CENPF, KIF11, KIF15, KIF4A, NDEL1, NEDD9, TPX2, TTK	80	spindle
GO:0005615	7.594e-05	7.401	23 ANGPTL4, AREG, BMP2, BMP6, CCL2, CCL7, CLCF1, CXCL3, FGF1, HBEGF, ICAM1, IL11, IL1A, IL1B, IL6, IL8, INHBA, LIF, PDGFA, PTHLH, THBD, TNFSF4, VEGFA	237	extracellular space
GO:0044427	1.897e-04	6.183	20 AURKB, BLM, BUB1, BUB1B, C21orf45, CDCA8, CDT1, CDYL, CENPF, CENPM, DSN1, ERCC6L, KIF22, MAD2L1, MCM2, MCM7, NDC80, ORC6L, POLA1, PRIM1	198	chromosomal part
GO:0044421	2.908e-04	11.74	29 ANGPTL4, AREG, BMP2, BMP6, CCL2, CCL7, CLCF1, COL15A1, COL21A1, CXCL3, ECM2, FGF1, HBEGF, ICAM1, IL11, IL1A, IL1B, IL6, IL8, INHBA, LAMC2, LIF, MFAP4, PDGFA, PRELP, PTHLH, THBD, TNFSF4, VEGFA	376	extracellular region part
GO:0005694	4.593e-04	7.744	22 AURKB, BIRC5, BLM, BUB1, BUB1B, C21orf45, CDCA8, CDT1, CDYL, CENPF, CENPM, DSN1, ERCC6L, HMGB2, KIF22, MAD2L1, MCM2, MCM7, NDC80, ORC6L, POLA1, PRIM1	248	chromosome
GO:0000776	5.005e-04	1.436	9 BUB1, BUB1B, CENPF, CENPM, DSN1, ERCC6L, KIF22, MAD2L1, NDC80	46	kinetochore
GO:0000777	2.776e-03	1.062	7 BUB1, BUB1B, CENPF, CENPM, DSN1, ERCC6L, NDC80	34	condensed chromosome kinetochore
GO:0000779	2.776e-03	1.062	7 BUB1, BUB1B, CENPF, CENPM, DSN1, ERCC6L, NDC80	34	condensed chromosome, centromeric region
GO:0005576	3.920e-03	21.02	39 ANGPTL4, AREG, BMP2, BMP6, C1orf56, CCL2, CCL7, CLCF1, COL15A1, COL21A1, CXCL3, ECM2, F10, FAM108B1, FGF1, FGF7, HBEGF, ICAM1, IL11, IL1A, IL1B, IL1RL1, IL6, IL8, INHBA, LAMC2, LIF, MFAP4, PDGFA, PDGFD, PRELP, PRSS12, PTHLH, ST3GAL1, SVEP1, THBD, TNFSF4, VEGFA, WISP1	673	extracellular region
GO:0000793	6.633e-03	2.061	9 BLM, BUB1, BUB1B, CENPF, CENPM, DSN1, ERCC6L, HMGB2, NDC80	66	condensed chromosome
GO:0015630	2.757e-02	10.02	21 AURKB, BUB1, BUB1B, CDC20, CDC6, CENPF, CKAP2, GABARAPL1, GABARAPL3, IL1RL1, KIF11, KIF15, KIF18B, KIF22, KIF4A, NDEL1, NEDD9, SPRY2, TNFAIP3, TPX2, TTK	321	microtubule cytoskeleton
GO:0005657	2.876e-02	0.8119	5 BLM, CDT1, MCM7, POLA1, PRIM1	26	replication fork
GO:0044454	4.353e-02	1.78	7 BLM, BUB1, MCM2, MCM7, ORC6L, POLA1, PRIM1	57	nuclear chromosome part

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005125	3.861e-07	2.113	16 AREG, BMP2, BMP6, CCL2, CCL7, CLCF1, IL11, IL1A, IL1B, IL6, IL8, INHBA, LIF, NAMPT, TNFSF4, VEGFA	71	cytokine activity
GO:0008083	8.411e-06	2.709	16 AREG, BMP2, BMP6, CLCF1, FGF1, FGF7, HBEGF, IL11, IL1A, IL1B, IL6, INHBA, LIF, PDGFA, PDGFD, VEGFA	91	growth factor activity
GO:0005102	2.780e-04	11.91	31 ANGPTL4, AREG, BMP2, BMP6, CCL2, CCL7, CLCF1, ECM2, FEM1B, FGF1, FGF7, HBEGF, ICAM1, IL11, IL1A, IL1B, IL6, IL8, INHBA, LIF, MFAP4, MTSS1, NAMPT, PDGFA, PDGFD, PDGFRB, PLXNC1, PTHLH, TGFBR1, TNFSF4, VEGFA	400	receptor binding
GO:0005515	2.117e-02	134.1	160 ADIPOR2, ANGPTL4, ANK2, AREG, ASAP2, ATF3, AURKB, BIRC5, BLM, BMP2, BMP6, BMPR2, BUB1B, C6orf145, CCL2, CCL7, CCNE2, CDC20, CDC6, CDC7, CDCA8, CDK2, CDKN1B, CDT1, CENPF, CHAF1A, CHMP1B, CLCF1, COL15A1, CXCR7, DCP1A, DHCR7, DSN1, DTL, ECM2, EGR2, ERCC6L, EZH2, F10, FANCG, FBXW7, FEM1B, FGF1, FGF7, FOSB, FOXO3, GABARAPL1, GCH1, GEM, GINS1, GINS2, GMNN, GNPTAB, HBEGF, HIVEP1, HMGB2, HTR2A, ICAM1, IER3, IL11, IL1A, IL1B, IL1RL1, IL6, IL8, INHBA, INSIG1, ITGA1, JARID2, JHDM1D, JMJD6, KCND3, KIF22, KIF4A, KLF7, KLHL21, LAMC2, LDLR, LIF, LMCD1, LRIG1, LRRFIP1, MAD2L1, MAP2K3, MCM10, MCM2, MCM5, MCM7, MFAP4, MSC, MTSS1, MYO1E, NAMPT, NDC80, NDEL1, NDRG1, NEDD9, NFIL3, NFKB1, NR3C1, NR4A1, ORC6L, PARP2, PDGFA, PDGFD, PDGFRB, PHLPPL, PIK3CD, PLK3, PLXNC1, PMEPA1, POLA1, POLD1, PPARD, PPL, PPP3CC, PRELP, PRIM1, PRKG1, PSMC3IP, PTGS2, PTHLH, RAD51AP1, RAD54B, RASGRP1, REL, RELB, RGS2, RICS, RRAD, RUNX1, SGK1, SKIL, SOX4, SOX9, SPRY2, SPRY4, SREBF2, SRF, STK38L, SVEP1, TGFBR1, THBD, TICAM1, TNFAIP3, TNFAIP6, TNFAIP8, TNFSF4, TP53BP2, TPX2, TRIB1, TRPC6, TTK, TXNIP, VCL, VEGFA, WEE1, WISP1, WWTR1, ZCCHC2	4505	protein binding
GO:0003677	3.743e-02	35.57	55 ATF3, BLM, BNC1, DDX11, DSCC1, EGR2, EGR3, ERCC6L, EZH2, FANCG, FOSB, FOXO3, HIVEP1, HIVEP2, HLX, HMGB2, HOXA10, JARID2, JMJD3, KIF15, KIF22, KIF4A, KLF7, LRRFIP1, MAFF, MCM2, MCM5, MCM7, MSC, NFATC1, NFIL3, NFKB1, NR3C1, NR4A1, NR4A2, NR4A3, ORC6L, PARP2, POLA1, POLD1, POLE2, PPARD, PSMC3IP, RAD51AP1, RAD54B, REL, RELB, RUNX1, SOX4, SOX9, SREBF2, SRF, TNFAIP3, ZNF35, ZNF672	1195	DNA binding
GO:0043565	4.731e-02	7.65	18 ATF3, FOSB, FOXO3, HLX, HOXA10, JMJD3, KIF22, MAFF, MCM2, NFIL3, NFKB1, NR3C1, NR4A1, NR4A2, NR4A3, PPARD, SOX9, SRF	257	sequence-specific DNA binding

Id	Pvalue	ExpCount	Count	Size	Term
04060	9.848e-05	4.663	18 BMP2, BMPR2, CCL2, CCL7, CLCF1, CXCL3, IL11, IL1A, IL1B, IL6, IL8, INHBA, LIF, PDGFA, PDGFRB, TGFBR1, TNFSF4, VEGFA	115	Cytokine-cytokine receptor interaction
00100	2.776e-03	0.9327	7 CYP51A1, DHCR7, HMGCR, IDI1, IDI2, SC4MOL, SQLE	23	Biosynthesis of steroids
04110	3.302e-03	3.974	14 BUB1, BUB1B, CCNE2, CDC20, CDC6, CDC7, CDK2, CDKN1B, MAD2L1, MCM2, MCM5, MCM7, ORC6L, WEE1	98	Cell cycle
03030	3.923e-03	1.338	8 MCM2, MCM5, MCM7, POLA1, POLD1, POLE2, PRIM1, RNASEH2A	33	DNA replication
04010	4.614e-02	7.421	17 DUSP5, FGF1, FGF7, IL1A, IL1B, MAP2K3, MAP3K4, NFKB1, NR4A1, PDGFA, PDGFRB, PPP3CC, RASA2, RASGRP1, RELB, SRF, TGFBR1	183	MAPK signaling pathway

No enriched terms

No enriched terms

Entrez genes

ABCA5ATP-binding cassette, sub-family A (ABC1), member 5 (213353_at), score: 0.62 ADIPOR2adiponectin receptor 2 (201346_at), score: 0.61 ANGPTL4angiopoietin-like 4 (221009_s_at), score: 1 ANK2ankyrin 2, neuronal (202920_at), score: 0.61 AQP3aquaporin 3 (Gill blood group) (39248_at), score: 0.74 AREGamphiregulin (205239_at), score: 0.68 ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (206414_s_at), score: 0.61 ATF3activating transcription factor 3 (202672_s_at), score: 0.59 ATP13A3ATPase type 13A3 (219558_at), score: 0.67 AURKBaurora kinase B (209464_at), score: -0.78 B3GNT2UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (219326_s_at), score: 0.88 B4GALT5UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 (221484_at), score: 0.52 BIRC5baculoviral IAP repeat-containing 5 (202095_s_at), score: -0.76 BLMBloom syndrome (205733_at), score: -0.76 BMP2bone morphogenetic protein 2 (205289_at), score: 0.83 BMP6bone morphogenetic protein 6 (206176_at), score: 0.68 BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase) (210214_s_at), score: 0.58 BNC1basonuclin 1 (206581_at), score: 0.58 BUB1budding uninhibited by benzimidazoles 1 homolog (yeast) (209642_at), score: -0.76 BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast) (203755_at), score: -0.76 C14orf1chromosome 14 open reading frame 1 (217188_s_at), score: 0.52 C17orf91chromosome 17 open reading frame 91 (214696_at), score: 0.83 C1orf56chromosome 1 open reading frame 56 (221222_s_at), score: 0.58 C21orf45chromosome 21 open reading frame 45 (219004_s_at), score: -0.78 C3orf52chromosome 3 open reading frame 52 (219474_at), score: 0.5 C4orf18chromosome 4 open reading frame 18 (219872_at), score: 0.57 C6orf145chromosome 6 open reading frame 145 (212923_s_at), score: 0.49 CCL2chemokine (C-C motif) ligand 2 (216598_s_at), score: 0.61 CCL7chemokine (C-C motif) ligand 7 (208075_s_at), score: 0.54 CCNE2cyclin E2 (205034_at), score: -0.76 CCNJcyclin J (219470_x_at), score: 0.6 CDC20cell division cycle 20 homolog (S. cerevisiae) (202870_s_at), score: -0.76 CDC6cell division cycle 6 homolog (S. cerevisiae) (203967_at), score: -0.81 CDC7cell division cycle 7 homolog (S. cerevisiae) (204510_at), score: -0.79 CDCA8cell division cycle associated 8 (221520_s_at), score: -0.76 CDK2cyclin-dependent kinase 2 (204252_at), score: -0.76 CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1) (209112_at), score: -0.75 CDT1chromatin licensing and DNA replication factor 1 (209832_s_at), score: -0.77 CDYLchromodomain protein, Y-like (203100_s_at), score: 0.57 CENPFcentromere protein F, 350/400ka (mitosin) (207828_s_at), score: -0.76 CENPMcentromere protein M (218741_at), score: -0.83 CHAF1Achromatin assembly factor 1, subunit A (p150) (214426_x_at), score: -0.79 CHMP1Bchromatin modifying protein 1B (218178_s_at), score: 0.59 CHST2carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 (203921_at), score: 0.53 CKAP2cytoskeleton associated protein 2 (218252_at), score: -0.82 CLCF1cardiotrophin-like cytokine factor 1 (219500_at), score: 0.55 COL15A1collagen, type XV, alpha 1 (203477_at), score: 0.56 COL21A1collagen, type XXI, alpha 1 (208096_s_at), score: 0.49 CORINcorin, serine peptidase (220356_at), score: 0.55 CPA3carboxypeptidase A3 (mast cell) (205624_at), score: 0.7 CXCL3chemokine (C-X-C motif) ligand 3 (207850_at), score: 0.76 CXCR7chemokine (C-X-C motif) receptor 7 (212977_at), score: 0.73 CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1 (216607_s_at), score: 0.63 DCP1ADCP1 decapping enzyme homolog A (S. cerevisiae) (218508_at), score: 0.5 DDX11DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) (208149_x_at), score: -0.8 DEPDC1DEP domain containing 1 (220295_x_at), score: -0.78 DHCR77-dehydrocholesterol reductase (201790_s_at), score: 0.61 DRAMdamage-regulated autophagy modulator (218627_at), score: 0.51 DSCC1defective in sister chromatid cohesion 1 homolog (S. cerevisiae) (219000_s_at), score: -0.76 DSN1DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) (219512_at), score: -0.8 DTLdenticleless homolog (Drosophila) (218585_s_at), score: -0.81 DUSP5dual specificity phosphatase 5 (209457_at), score: 0.65 ECM2extracellular matrix protein 2, female organ and adipocyte specific (206101_at), score: 0.59 EGR2early growth response 2 (Krox-20 homolog, Drosophila) (205249_at), score: 0.77 EGR3early growth response 3 (206115_at), score: 0.55 ENTPD7ectonucleoside triphosphate diphosphohydrolase 7 (220153_at), score: 0.78 ERCC6Lexcision repair cross-complementing rodent repair deficiency, complementation group 6-like (219650_at), score: -0.76 EZH2enhancer of zeste homolog 2 (Drosophila) (203358_s_at), score: -0.79 F10coagulation factor X (205620_at), score: 0.57 F3coagulation factor III (thromboplastin, tissue factor) (204363_at), score: 0.56 FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (214285_at), score: 0.63 FAM108B1family with sequence similarity 108, member B1 (220285_at), score: 0.63 FANCGFanconi anemia, complementation group G (203564_at), score: -0.79 FBXW7F-box and WD repeat domain containing 7 (218751_s_at), score: 0.72 FEM1Bfem-1 homolog b (C. elegans) (212367_at), score: 0.61 FGF1fibroblast growth factor 1 (acidic) (205117_at), score: 0.76 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: 0.72 FOSBFBJ murine osteosarcoma viral oncogene homolog B (202768_at), score: 0.86 FOXO3forkhead box O3 (204132_s_at), score: 0.54 FRYfurry homolog (Drosophila) (204072_s_at), score: 0.63 GABARAPL1GABA(A) receptor-associated protein like 1 (208868_s_at), score: 0.59 GABARAPL3GABA(A) receptors associated protein like 3 (pseudogene) (211458_s_at), score: 0.5 GALNAC4S-6STB cell RAG associated protein (203066_at), score: 0.58 GALNT4UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4) (220442_at), score: 0.6 GCH1GTP cyclohydrolase 1 (204224_s_at), score: 0.69 GEMGTP binding protein overexpressed in skeletal muscle (204472_at), score: 0.84 GFPT2glutamine-fructose-6-phosphate transaminase 2 (205100_at), score: 0.78 GINS1GINS complex subunit 1 (Psf1 homolog) (206102_at), score: -0.8 GINS2GINS complex subunit 2 (Psf2 homolog) (221521_s_at), score: -0.82 GMNNgeminin, DNA replication inhibitor (218350_s_at), score: -0.76 GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (212959_s_at), score: 0.51 GPR183G protein-coupled receptor 183 (205419_at), score: 0.74 HBEGFheparin-binding EGF-like growth factor (203821_at), score: 0.84 HIPK3homeodomain interacting protein kinase 3 (210148_at), score: 0.51 HIVEP1human immunodeficiency virus type I enhancer binding protein 1 (204512_at), score: 0.75 HIVEP2human immunodeficiency virus type I enhancer binding protein 2 (212642_s_at), score: 0.74 HK2hexokinase 2 (202934_at), score: 0.61 HLXH2.0-like homeobox (214438_at), score: 0.71 HMGB2high-mobility group box 2 (208808_s_at), score: -0.83 HMGCR3-hydroxy-3-methylglutaryl-Coenzyme A reductase (202539_s_at), score: 0.53 HMGCS13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) (221750_at), score: 0.58 HMMRhyaluronan-mediated motility receptor (RHAMM) (207165_at), score: -0.76 HOXA10homeobox A10 (213150_at), score: -0.79 HSPB3heat shock 27kDa protein 3 (206375_s_at), score: 0.6 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (207135_at), score: 0.56 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: 0.82 IDI1isopentenyl-diphosphate delta isomerase 1 (204615_x_at), score: 0.75 IDI2isopentenyl-diphosphate delta isomerase 2 (217631_at), score: 0.65 IER3immediate early response 3 (201631_s_at), score: 0.5 IL11interleukin 11 (206924_at), score: 0.74 IL1Ainterleukin 1, alpha (210118_s_at), score: 0.66 IL1Binterleukin 1, beta (39402_at), score: 0.68 IL1RL1interleukin 1 receptor-like 1 (207526_s_at), score: 0.6 IL6interleukin 6 (interferon, beta 2) (205207_at), score: 0.86 IL8interleukin 8 (211506_s_at), score: 0.8 INHBAinhibin, beta A (210511_s_at), score: 0.6 INSIG1insulin induced gene 1 (201627_s_at), score: 0.9 ITGA1integrin, alpha 1 (214660_at), score: 0.53 JARID2jumonji, AT rich interactive domain 2 (203297_s_at), score: 0.66 JHDM1Djumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (221778_at), score: 0.9 JMJD3jumonji domain containing 3, histone lysine demethylase (213146_at), score: 0.8 JMJD6jumonji domain containing 6 (212722_s_at), score: 0.67 KCND3potassium voltage-gated channel, Shal-related subfamily, member 3 (213832_at), score: 0.6 KIAA0247KIAA0247 (202181_at), score: 0.56 KIAA0586KIAA0586 (205631_at), score: -0.79 KIAA1024KIAA1024 (215081_at), score: 0.57 KIAA1644KIAA1644 (52837_at), score: 0.72 KIF11kinesin family member 11 (204444_at), score: -0.77 KIF15kinesin family member 15 (219306_at), score: -0.75 KIF18Bkinesin family member 18B (222039_at), score: -0.81 KIF22kinesin family member 22 (202183_s_at), score: -0.78 KIF4Akinesin family member 4A (218355_at), score: -0.78 KLF7Kruppel-like factor 7 (ubiquitous) (204334_at), score: 0.58 KLHL21kelch-like 21 (Drosophila) (203068_at), score: 0.51 LAMC2laminin, gamma 2 (202267_at), score: 0.59 LDLRlow density lipoprotein receptor (202068_s_at), score: 0.56 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: 0.94 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: 0.83 LMNB1lamin B1 (203276_at), score: -0.77 LOH3CR2Aloss of heterozygosity, 3, chromosomal region 2, gene A (220244_at), score: 0.83 LRIG1leucine-rich repeats and immunoglobulin-like domains 1 (211596_s_at), score: 0.58 LRRFIP1leucine rich repeat (in FLII) interacting protein 1 (201861_s_at), score: 0.49 LUZP1leucine zipper protein 1 (221832_s_at), score: 0.56 MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast) (203362_s_at), score: -0.81 MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) (36711_at), score: 0.5 MAMLD1mastermind-like domain containing 1 (205088_at), score: 0.49 MAP2K3mitogen-activated protein kinase kinase 3 (207667_s_at), score: 0.57 MAP3K4mitogen-activated protein kinase kinase kinase 4 (216199_s_at), score: 0.51 MCM10minichromosome maintenance complex component 10 (220651_s_at), score: -0.78 MCM2minichromosome maintenance complex component 2 (202107_s_at), score: -0.79 MCM5minichromosome maintenance complex component 5 (216237_s_at), score: -0.82 MCM7minichromosome maintenance complex component 7 (210983_s_at), score: -0.75 MDM1Mdm1 nuclear protein homolog (mouse) (213761_at), score: -0.76 MFAP4microfibrillar-associated protein 4 (212713_at), score: 0.51 MSCmusculin (activated B-cell factor-1) (209928_s_at), score: 0.53 MTSS1metastasis suppressor 1 (203037_s_at), score: 0.64 MYO1Emyosin IE (203072_at), score: 0.51 NAMPTnicotinamide phosphoribosyltransferase (217738_at), score: 0.56 NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae) (204162_at), score: -0.76 NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 1 (208093_s_at), score: 0.59 NDRG1N-myc downstream regulated 1 (200632_s_at), score: 0.52 NEDD9neural precursor cell expressed, developmentally down-regulated 9 (202149_at), score: 0.57 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: 0.86 NFIL3nuclear factor, interleukin 3 regulated (203574_at), score: 0.59 NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: 0.6 NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (201866_s_at), score: 0.66 NR4A1nuclear receptor subfamily 4, group A, member 1 (202340_x_at), score: 0.86 NR4A2nuclear receptor subfamily 4, group A, member 2 (216248_s_at), score: 0.75 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: 0.97 NUPL1nucleoporin like 1 (204435_at), score: 0.56 ORC6Lorigin recognition complex, subunit 6 like (yeast) (219105_x_at), score: -0.8 PANK3pantothenate kinase 3 (218433_at), score: 0.51 PANX1pannexin 1 (204715_at), score: 0.57 PARP2poly (ADP-ribose) polymerase 2 (214086_s_at), score: -0.78 PCSK7proprotein convertase subtilisin/kexin type 7 (203118_at), score: -0.77 PDGFAplatelet-derived growth factor alpha polypeptide (205463_s_at), score: 0.65 PDGFDplatelet derived growth factor D (219304_s_at), score: 0.6 PDGFRBplatelet-derived growth factor receptor, beta polypeptide (202273_at), score: 0.51 PHLPPLPH domain and leucine rich repeat protein phosphatase-like (213407_at), score: 0.52 PIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide (203879_at), score: 0.8 PLCXD1phosphatidylinositol-specific phospholipase C, X domain containing 1 (218951_s_at), score: 0.54 PLK3polo-like kinase 3 (Drosophila) (204958_at), score: 0.5 PLXNC1plexin C1 (213241_at), score: 0.55 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: 0.9 POLA1polymerase (DNA directed), alpha 1, catalytic subunit (204835_at), score: -0.82 POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa (203422_at), score: -0.82 POLE2polymerase (DNA directed), epsilon 2 (p59 subunit) (205909_at), score: -0.75 PPARDperoxisome proliferator-activated receptor delta (37152_at), score: 0.54 PPLperiplakin (203407_at), score: 0.65 PPP3CCprotein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (207000_s_at), score: 0.69 PRELPproline/arginine-rich end leucine-rich repeat protein (204223_at), score: 0.56 PRIM1primase, DNA, polypeptide 1 (49kDa) (205053_at), score: -0.82 PRKG1protein kinase, cGMP-dependent, type I (207119_at), score: 0.65 PRSS12protease, serine, 12 (neurotrypsin, motopsin) (205515_at), score: 0.51 PSMC3IPPSMC3 interacting protein (213951_s_at), score: -0.79 PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (204748_at), score: 0.54 PTHLHparathyroid hormone-like hormone (211756_at), score: 0.72 RAD51AP1RAD51 associated protein 1 (204146_at), score: -0.75 RAD54BRAD54 homolog B (S. cerevisiae) (219494_at), score: -0.75 RASA2RAS p21 protein activator 2 (206636_at), score: 0.56 RASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated) (205590_at), score: 0.78 RASSF8Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 (207754_at), score: 0.65 RELv-rel reticuloendotheliosis viral oncogene homolog (avian) (206036_s_at), score: 0.68 RELBv-rel reticuloendotheliosis viral oncogene homolog B (205205_at), score: 0.71 RGPD5RANBP2-like and GRIP domain containing 5 (210676_x_at), score: 0.58 RGS2regulator of G-protein signaling 2, 24kDa (202388_at), score: 0.62 RICSRho GTPase-activating protein (203431_s_at), score: 0.49 RNASEH2Aribonuclease H2, subunit A (203022_at), score: -0.76 RRADRas-related associated with diabetes (204802_at), score: 0.61 RUNX1runt-related transcription factor 1 (209360_s_at), score: 0.72 SC4MOLsterol-C4-methyl oxidase-like (209146_at), score: 0.69 SCDstearoyl-CoA desaturase (delta-9-desaturase) (200832_s_at), score: 0.57 SGK1serum/glucocorticoid regulated kinase 1 (201739_at), score: 0.68 SKILSKI-like oncogene (206675_s_at), score: 0.8 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: 0.85 SLC2A14solute carrier family 2 (facilitated glucose transporter), member 14 (222088_s_at), score: 0.7 SLC2A3solute carrier family 2 (facilitated glucose transporter), member 3 (202499_s_at), score: 0.49 SLC2A3P1solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 1 (221751_at), score: 0.58 SMOXspermine oxidase (210357_s_at), score: 0.81 SOX4SRY (sex determining region Y)-box 4 (201417_at), score: 0.55 SOX9SRY (sex determining region Y)-box 9 (202935_s_at), score: 0.79 SPATA2Lspermatogenesis associated 2-like (214965_at), score: 0.71 SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: 0.69 SPRY2sprouty homolog 2 (Drosophila) (204011_at), score: 0.65 SPRY4sprouty homolog 4 (Drosophila) (221489_s_at), score: 0.57 SPSB1splA/ryanodine receptor domain and SOCS box containing 1 (219677_at), score: 0.64 SQLEsqualene epoxidase (213562_s_at), score: 0.78 SREBF2sterol regulatory element binding transcription factor 2 (201247_at), score: 0.49 SRFserum response factor (c-fos serum response element-binding transcription factor) (202401_s_at), score: 0.76 ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (208322_s_at), score: 0.76 STBD1starch binding domain 1 (203986_at), score: 0.49 STK38Lserine/threonine kinase 38 like (212572_at), score: 0.9 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: 0.56 TACSTD2tumor-associated calcium signal transducer 2 (202286_s_at), score: 0.75 TGFBR1transforming growth factor, beta receptor 1 (206943_at), score: 0.89 THBDthrombomodulin (203887_s_at), score: 0.86 TICAM1toll-like receptor adaptor molecule 1 (213191_at), score: 0.51 TM6SF1transmembrane 6 superfamily member 1 (219892_at), score: 0.52 TMEM194Atransmembrane protein 194A (212621_at), score: -0.82 TMEM41Btransmembrane protein 41B (212623_at), score: 0.54 TNFAIP3tumor necrosis factor, alpha-induced protein 3 (202644_s_at), score: 0.67 TNFAIP6tumor necrosis factor, alpha-induced protein 6 (206026_s_at), score: 0.57 TNFAIP8tumor necrosis factor, alpha-induced protein 8 (210260_s_at), score: 0.51 TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (207426_s_at), score: 0.53 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: 0.68 TPX2TPX2, microtubule-associated, homolog (Xenopus laevis) (210052_s_at), score: -0.77 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: 0.76 TRPC6transient receptor potential cation channel, subfamily C, member 6 (217287_s_at), score: 0.6 TTC17tetratricopeptide repeat domain 17 (218972_at), score: 0.65 TTKTTK protein kinase (204822_at), score: -0.8 TXNIPthioredoxin interacting protein (201008_s_at), score: -0.78 URB2URB2 ribosome biogenesis 2 homolog (S. cerevisiae) (205284_at), score: 0.55 VCLvinculin (200930_s_at), score: 0.68 VEGFAvascular endothelial growth factor A (211527_x_at), score: 0.83 WEE1WEE1 homolog (S. pombe) (212533_at), score: -0.84 WISP1WNT1 inducible signaling pathway protein 1 (206796_at), score: 0.62 WWTR1WW domain containing transcription regulator 1 (202132_at), score: 0.51 YOD1YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) (215150_at), score: 0.58 YRDCyrdC domain containing (E. coli) (218647_s_at), score: 0.73 ZCCHC2zinc finger, CCHC domain containing 2 (219062_s_at), score: 0.51 ZNF35zinc finger protein 35 (206096_at), score: 0.61 ZNF672zinc finger protein 672 (218068_s_at), score: 0.63

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
1Twin.CEL	1	2	DS-twin	hgu133plus2	Down	DS-twin 1
E-TABM-263-raw-cel-1515486351.cel	36	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486331.cel	35	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515485851.cel	11	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486231.cel	30	6	Cycle	hgu133a2	none	Cycle 1