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Module #910, TG: 2.4, TC: 1.4, 109 probes, 108 Entrez genes, 12 conditions
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The image plot shows the color-coded level of gene expression, for the
genes and conditions in a given transcription module. The genes are on
the horizontal, the conditions on the vertical axis.
The genes are ordered according to their ISA gene scores, similarly
the conditions are ordered according to their condition scores. The
score of a gene means the «degree of inclusion» in
the module: a high score gene is essential in the module.
Condition scores can also be negative, that means that the genes of
the module are all down-regulated in the condition. Here the absolute
value of the score gives the «degree of inclusion».
The plots above and beside the expression matrix show the gene scores
and condition scores, respectively.
Note that the plot is interactive, you can see the name of the gene
and condition under the mouse cursor.
The expression matrix was normalized to have mean zero and standard
deviation one for every gene separately across all conditions
(i.e. not just for the conditions in the module).
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Under-expression is coded with green,
over-expression with red color.
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The GO tree — Biological processes
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This is one of three sections showing Gene Ontology enrichment of the
current module: in this case for biological processes.
The graph shows the hierarchy of the GO categories, their enrichment
for the current module is color coded, and the blue number beside the
category is the minus log ten p-value of the enrichment. (Calculated
using the standard hypergeometric test.) The color of the arrows code
«is a» (cyan) and «part of» relationships.
The tree was built the following way. First all GO terms with more
significant enrichment p-value than 0.05 were collected. Then all
paths from these terms to the root node of the GO tree were included
too. If a GO term is included more than once in the tree, then the
green numbers show 1) the id of the node, this makes it easier to find
other appereances of the term, and 2) the number of appearences.
Note that the same GO category might show up on the graph many
times. This is because the GO was «straightened» for this
graph, i.e. if there are more paths from a GO term to the root node of
the tree, all of them are included. The green numbers
Move the mouse cursor over the terms to get their definition. Clicking
on them takes you to the corresponding Gene Ontology web page.
If you cannot see a graph here at all, that means that there were no
significantly enriched GO categories, at the 0.05 level.
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The GO tree — Cellular Components
HELP
This is one of three sections showing Gene Ontology enrichment of the
current module: in this case for cellular components.
The graph shows the hierarchy of the GO categories, their enrichment
for the current module is color coded, and the blue number beside the
category is the minus log ten p-value of the enrichment. (Calculated
using the standard hypergeometric test.) The color of the arrows code
«is a» (cyan) and «part of» relationships.
The tree was built the following way. First all GO terms with more
significant enrichment p-value than 0.05 were collected. Then all
paths from these terms to the root node of the GO tree were included
too. If a GO term is included more than once in the tree, then the
green numbers show 1) the id of the node, this makes it easier to find
other appereances of the term, and 2) the number of appearences.
Note that the same GO category might show up on the graph many
times. This is because the GO was «straightened» for this
graph, i.e. if there are more paths from a GO term to the root node of
the tree, all of them are included. The green numbers
Move the mouse cursor over the terms to get their definition. Clicking
on them takes you to the corresponding Gene Ontology web page.
If you cannot see a graph here at all, that means that there were no
significantly enriched GO categories, at the 0.05 level.
— Click on the Help button again to close this help window.
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The GO tree — Molecular Function
HELP
This is one of three sections showing Gene Ontology enrichment of the
current module: in this case for molecular function.
The graph shows the hierarchy of the GO categories, their enrichment
for the current module is color coded, and the blue number beside the
category is the minus log ten p-value of the enrichment. (Calculated
using the standard hypergeometric test.) The color of the arrows code
«is a» (cyan) and «part of» relationships.
The tree was built the following way. First all GO terms with more
significant enrichment p-value than 0.05 were collected. Then all
paths from these terms to the root node of the GO tree were included
too. If a GO term is included more than once in the tree, then the
green numbers show 1) the id of the node, this makes it easier to find
other appereances of the term, and 2) the number of appearences.
Note that the same GO category might show up on the graph many
times. This is because the GO was «straightened» for this
graph, i.e. if there are more paths from a GO term to the root node of
the tree, all of them are included. The green numbers
Move the mouse cursor over the terms to get their definition. Clicking
on them takes you to the corresponding Gene Ontology web page.
If you cannot see a graph here at all, that means that there were no
significantly enriched GO categories, at the 0.05 level.
— Click on the Help button again to close this help window.
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GO BP test for over-representation
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List of all enriched GO categories (biological processes), at the 0.05
p-value level.
The columns:
- ExpCount is the expected count of genes in the
module annotated with the given GO term, just by chance.
- Count
is the number of genes in the module annotated with the given GO
term.
- Size is the total number of genes (in our universe)
annotated with the GO term.
Clicking on Count shows the genes that drive the
enrichment. You can also click on the individual numbers in
the Count column, to show the driving genes for that individual
GO category.
Clicking on the GO identifiers takes you to the Gene Ontology web
pages.
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| Id | Pvalue | ExpCount | Count | Size | Term |
| GO:0006699 | 1.007e-02 | 0.02057 | 2
AKR1D1, CYP7B1 | 2 | bile acid biosynthetic process |
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GO CC test for over-representation
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List of all enriched GO categories (cellular components), at the 0.05
p-value level.
The columns:
- ExpCount is the expected count of genes in the
module annotated with the given GO term, just by chance.
- Count
is the number of genes in the module annotated with the given GO
term.
- Size is the total number of genes (in our universe)
annotated with the GO term.
Clicking on Count shows the genes that drive the
enrichment. You can also click on the individual numbers in
the Count column, to show the driving genes for that individual
GO category.
Clicking on the GO identifiers takes you to the Gene Ontology web
pages.
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GO MF test for over-representation
HELP
List of all enriched GO categories (molecular function), at the 0.05
p-value level.
The columns:
- ExpCount is the expected count of genes in the
module annotated with the given GO term, just by chance.
- Count
is the number of genes in the module annotated with the given GO
term.
- Size is the total number of genes (in our universe)
annotated with the GO term.
Clicking on Count shows the genes that drive the
enrichment. You can also click on the individual numbers in
the Count column, to show the driving genes for that individual
GO category.
Clicking on the GO identifiers takes you to the Gene Ontology web
pages.
— Click on the Help button again to close this help window.
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KEGG Pathway test for over-representation
HELP
List of all enriched KEGG pathways, at the 0.05
p-value level.
The columns:
- ExpCount is the expected count of genes in the
module annotated with the given KEGG pathway, just by chance.
- Count
is the number of genes in the module annotated with the given KEGG
pathway.
- Size is the total number of genes (in our universe)
annotated with the KEGG pathway.
Clicking on Count shows the genes that drive the
enrichment. You can also click on the individual numbers in
the Count column, to show the driving genes for that individual
KEGG pathway.
Clicking on the KEGG identifiers takes you to the KEGG web site.
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miRNA test for over-representation
HELP
List of all enriched miRNA families, at the 0.05
p-value level.
The columns:
- ExpCount is the expected count of genes in the
module regulated by the given miRNA family, just by chance.
- Count
is the number of genes in the module regulated by the given miRNA
family.
- Size is the total number of genes (in our universe)
regulated with the given miRNA family.
Clicking on Count shows the genes that drive the
enrichment. You can also click on the individual numbers in
the Count column, to show the driving genes for that individual
miRNA family.
The miRNA regulation data was taken from the TargetScan database.
(Only the conserved sites were used for the current analysis.)
Clicking on the miRNA names takes you to the TargetScan web site.
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Chromosome test for over-representation
HELP
List of all enriched Chromosomes, at the 0.05
p-value level.
The columns:
- ExpCount is the expected number of genes in the
module on the given chromosome, just by chance.
- Count
is the number of genes in the module on the given chromosome.
- Size is the total number of genes (in our universe)
on the given chromosome.
Clicking on Count shows the genes that drive the
enrichment. You can also click on the individual numbers in
the Count column, to show the driving genes for that individual
chromosome.
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HELP
A list of all genes in the current module, in alphabetical order. The
size of the text corresponds to the gene scores.
Note that some gene symbols may show up more than once, if many
probes match the same Entrez gene.
Genes with no Entrez mapping are given separately, with their
Affymetrics probe ID.
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Entrez genes
AAASachalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A) (218075_at), score: -0.5
ACSL4acyl-CoA synthetase long-chain family member 4 (202422_s_at), score: 0.81
AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (207102_at), score: -0.48
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (202652_at), score: -0.45
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 (219103_at), score: -0.45
ATN1atrophin 1 (40489_at), score: -0.59
ATP2C1ATPase, Ca++ transporting, type 2C, member 1 (211137_s_at), score: 0.79
BACE2beta-site APP-cleaving enzyme 2 (217867_x_at), score: -0.43
BRD4bromodomain containing 4 (202102_s_at), score: -0.46
BTBD2BTB (POZ) domain containing 2 (207722_s_at), score: -0.53
C10orf97chromosome 10 open reading frame 97 (218297_at), score: 0.81
C16orf57chromosome 16 open reading frame 57 (218060_s_at), score: -0.46
C1orf159chromosome 1 open reading frame 159 (219337_at), score: -0.42
C20orf149chromosome 20 open reading frame 149 (218010_x_at), score: -0.44
C4orf43chromosome 4 open reading frame 43 (218513_at), score: 0.89
C5orf22chromosome 5 open reading frame 22 (203738_at), score: 0.77
C5orf44chromosome 5 open reading frame 44 (218674_at), score: 0.86
CD2APCD2-associated protein (203593_at), score: 0.79
CDC42BPBCDC42 binding protein kinase beta (DMPK-like) (217849_s_at), score: -0.45
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) (218578_at), score: 0.77
CHKAcholine kinase alpha (204233_s_at), score: -0.44
CHORDC1cysteine and histidine-rich domain (CHORD)-containing 1 (218566_s_at), score: 0.83
CHUKconserved helix-loop-helix ubiquitous kinase (209666_s_at), score: 0.83
CICcapicua homolog (Drosophila) (212784_at), score: -0.62
CITcitron (rho-interacting, serine/threonine kinase 21) (212801_at), score: -0.43
CLN5ceroid-lipofuscinosis, neuronal 5 (204084_s_at), score: 0.82
CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1 (207386_at), score: -0.46
DESdesmin (216947_at), score: -0.49
DMWDdystrophia myotonica, WD repeat containing (33768_at), score: -0.55
DNAJB9DnaJ (Hsp40) homolog, subfamily B, member 9 (202843_at), score: 0.79
DNM1dynamin 1 (215116_s_at), score: -0.5
DTX4deltex homolog 4 (Drosophila) (212611_at), score: -0.45
EIF2AK3eukaryotic translation initiation factor 2-alpha kinase 3 (218696_at), score: 0.79
EIF4Eeukaryotic translation initiation factor 4E (201436_at), score: 0.79
ERBB2IPerbb2 interacting protein (217941_s_at), score: 0.78
FAM18Bfamily with sequence similarity 18, member B (218446_s_at), score: 1
FAM38Bfamily with sequence similarity 38, member B (219602_s_at), score: -0.52
FBLN2fibulin 2 (203886_s_at), score: -0.43
FLGfilaggrin (215704_at), score: -0.45
FOXK2forkhead box K2 (203064_s_at), score: -0.44
FRG1FSHD region gene 1 (204145_at), score: 0.8
G3BP2GTPase activating protein (SH3 domain) binding protein 2 (208841_s_at), score: 0.87
GMCL1germ cell-less homolog 1 (Drosophila) (218458_at), score: 0.92
HDAC7histone deacetylase 7 (217937_s_at), score: -0.51
HISPPD1histidine acid phosphatase domain containing 1 (203253_s_at), score: 0.83
HNRNPH2heterogeneous nuclear ribonucleoprotein H2 (H') (201132_at), score: 0.79
HSPB6heat shock protein, alpha-crystallin-related, B6 (214767_s_at), score: -0.47
JMJD1Cjumonji domain containing 1C (221763_at), score: 0.77
JUNDjun D proto-oncogene (203751_x_at), score: -0.54
KCNJ16potassium inwardly-rectifying channel, subfamily J, member 16 (219564_at), score: -0.43
KIAA0562KIAA0562 (204075_s_at), score: 0.77
KIR3DX1killer cell immunoglobulin-like receptor, three domains, X1 (216428_x_at), score: -0.43
LARP4La ribonucleoprotein domain family, member 4 (214155_s_at), score: 0.84
LOC100132540similar to LOC339047 protein (214870_x_at), score: -0.66
LOC286434hypothetical protein LOC286434 (222196_at), score: -0.46
LOC339047hypothetical protein LOC339047 (221501_x_at), score: -0.55
LOC399491LOC399491 protein (214035_x_at), score: -0.5
LRDDleucine-rich repeats and death domain containing (221640_s_at), score: -0.42
LRP2low density lipoprotein-related protein 2 (205710_at), score: -0.43
MAP1Smicrotubule-associated protein 1S (218522_s_at), score: -0.58
MAP7D1MAP7 domain containing 1 (217943_s_at), score: -0.45
MCF2L2MCF.2 cell line derived transforming sequence-like 2 (215112_x_at), score: -0.47
MED23mediator complex subunit 23 (218846_at), score: 0.78
MFFmitochondrial fission factor (219137_s_at), score: 0.77
MMRN2multimerin 2 (219091_s_at), score: -0.49
MUC1mucin 1, cell surface associated (207847_s_at), score: -0.45
N4BP3Nedd4 binding protein 3 (214775_at), score: -0.44
NDUFA5NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa (201304_at), score: 0.82
NFATC4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 (205897_at), score: -0.47
NPIPnuclear pore complex interacting protein (204538_x_at), score: -0.62
NRN1neuritin 1 (218625_at), score: -0.51
NTNG1netrin G1 (206713_at), score: -0.46
NUP160nucleoporin 160kDa (212709_at), score: 0.77
OLFML2Bolfactomedin-like 2B (213125_at), score: -0.47
OSTM1osteopetrosis associated transmembrane protein 1 (218196_at), score: 0.92
P2RY5purinergic receptor P2Y, G-protein coupled, 5 (218589_at), score: -0.42
PAQR3progestin and adipoQ receptor family member III (213372_at), score: 0.81
PEX6peroxisomal biogenesis factor 6 (204545_at), score: -0.48
PIP5K1Cphosphatidylinositol-4-phosphate 5-kinase, type I, gamma (212518_at), score: -0.45
PKD1polycystic kidney disease 1 (autosomal dominant) (202328_s_at), score: -0.47
PNPLA2patatin-like phospholipase domain containing 2 (212705_x_at), score: -0.73
POLR2Apolymerase (RNA) II (DNA directed) polypeptide A, 220kDa (202725_at), score: -0.48
PRMT3protein arginine methyltransferase 3 (213320_at), score: 0.87
PROX1prospero homeobox 1 (207401_at), score: -0.47
PTPROprotein tyrosine phosphatase, receptor type, O (211600_at), score: -0.48
RAB1ARAB1A, member RAS oncogene family (213440_at), score: 0.82
RAB7ARAB7A, member RAS oncogene family (211960_s_at), score: 0.79
RANBP6RAN binding protein 6 (213019_at), score: 0.84
RBM15BRNA binding motif protein 15B (202689_at), score: -0.45
RNF11ring finger protein 11 (208924_at), score: 0.82
SCAMP4secretory carrier membrane protein 4 (213244_at), score: -0.53
SF3A2splicing factor 3a, subunit 2, 66kDa (37462_i_at), score: -0.42
SLC33A1solute carrier family 33 (acetyl-CoA transporter), member 1 (203165_s_at), score: 0.86
SLMO2slowmo homolog 2 (Drosophila) (217851_s_at), score: 0.88
SOLHsmall optic lobes homolog (Drosophila) (204275_at), score: -0.42
STXBP3syntaxin binding protein 3 (203310_at), score: 0.78
TAF2TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa (209523_at), score: 0.85
TICAM2toll-like receptor adaptor molecule 2 (214658_at), score: 0.96
TM9SF3transmembrane 9 superfamily member 3 (217758_s_at), score: 0.78
TMBIM4transmembrane BAX inhibitor motif containing 4 (219206_x_at), score: 0.77
TMED7transmembrane emp24 protein transport domain containing 7 (209404_s_at), score: 0.83
TMEM123transmembrane protein 123 (211967_at), score: 0.83
TMEM30Atransmembrane protein 30A (217743_s_at), score: 0.79
TMF1TATA element modulatory factor 1 (213024_at), score: 0.79
VPS37Bvacuolar protein sorting 37 homolog B (S. cerevisiae) (221704_s_at), score: -0.44
YTHDC2YTH domain containing 2 (213077_at), score: 0.84
ZCCHC10zinc finger, CCHC domain containing 10 (221193_s_at), score: 0.78
ZFP36L1zinc finger protein 36, C3H type-like 1 (211965_at), score: -0.5
Non-Entrez genes
208841_s_atUnknown, score: -0.42
HELP
Conditions in the module, given in the same order as on the expression
plot above. Red color means over-expression, green under-expression in
the given condition.
The barplot below shows the condition (sample) scores. A separate bar
is shown for each sample, its height is the corresponding score of the
sample in the module. The red and green numbers on the bars are the
sample scores expressed in percents, i.e. 100% is 1.0.
The red and green lines show the module thresholds, samples above
the red line and below the green line are included in the module.
The different experiments that were part of the study, are separated
by dashed vertical lines.
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| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
| t21b 08-03.CEL | 5 | 1 | DS-CC | hgu133a | Down | DS-CC 5 |
| E-TABM-263-raw-cel-1515486211.cel | 29 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| ctrl a 08-03.CEL | 1 | 1 | DS-CC | hgu133a | none | DS-CC 1 |
| E-GEOD-3860-raw-cel-1561690304.cel | 8 | 5 | HGPS | hgu133a | none | GMO8398C |
| t21a 08-03.CEL | 4 | 1 | DS-CC | hgu133a | Down | DS-CC 4 |
| E-TABM-263-raw-cel-1515485651.cel | 1 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485751.cel | 6 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486091.cel | 23 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485811.cel | 9 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485771.cel | 7 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486371.cel | 37 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485891.cel | 13 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
© 2008-2010 Computational Biology Group, Department of Medical Genetics,
University of Lausanne, Switzerland
