Under-expression is coded with green,
over-expression with red color.
skeletal system development
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
ossification
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
osteoblast differentiation
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone.
defense response
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
signal transduction
The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
transcription
The synthesis of either RNA on a template of DNA or DNA on a template of RNA.
transcription, DNA-dependent
The synthesis of RNA on a template of DNA.
regulation of transcription, DNA-dependent
Any process that modulates the frequency, rate or extent of DNA-dependent transcription.
regulation of transcription from RNA polymerase II promoter
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
transcription from RNA polymerase II promoter
The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
chemotaxis
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
response to stress
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
inflammatory response
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
cell communication
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
cell-cell signaling
Any process that mediates the transfer of information from one cell to another.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
behavior
The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
locomotory behavior
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
biosynthetic process
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
response to external stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
response to wounding
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
regulation of biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
gene expression
The process by which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
regulation of gene expression
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
regulation of macromolecule biosynthetic process
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
RNA metabolic process
The chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
cell differentiation
The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.
regulation of ossification
Any process that modulates the frequency, rate or extent of bone formation.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
regulation of cellular biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
regulation of response to external stimulus
Any process that modulates the frequency, rate or extent of a response to an external stimulus.
positive regulation of response to external stimulus
Any process that activates, maintains or increases the rate of a response to an external stimulus.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
RNA biosynthetic process
The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.
regulation of tissue remodeling
Any process that modulates the frequency, rate, or extent of tissue remodeling.
cellular macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
cellular biopolymer metabolic process
The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
cellular biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
locomotion
Self-propelled movement of a cell or organism from one location to another.
regulation of locomotion
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
positive regulation of locomotion
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
response to chemical stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
taxis
The directed movement of a motile cell or organism in response to an external stimulus.
macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
biopolymer metabolic process
The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.
biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
regulation of transcription
Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
regulation of cell differentiation
Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.
positive regulation of cell differentiation
Any process that activates or increases the frequency, rate or extent of cell differentiation.
regulation of osteoblast differentiation
Any process that modulates the frequency, rate or extent of osteoblast differentiation.
positive regulation of osteoblast differentiation
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
bone remodeling
The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
regulation of bone remodeling
Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
positive regulation of behavior
Any process that activates or increases the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of response to stimulus
Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
anatomical structure formation
The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
tissue remodeling
The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of developmental process
Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of behavior
Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.
response to stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
regulation of chemotaxis
Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
positive regulation of chemotaxis
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
positive regulation of developmental process
Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
regulation of RNA metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
regulation of macromolecule metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
bone development
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
all
This term is the most general term possible
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
positive regulation of locomotion
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
positive regulation of developmental process
Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
regulation of locomotion
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of developmental process
Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
regulation of response to stimulus
Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of macromolecule metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
signal transduction
The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of tissue remodeling
Any process that modulates the frequency, rate, or extent of tissue remodeling.
anatomical structure formation
The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
regulation of ossification
Any process that modulates the frequency, rate or extent of bone formation.
regulation of cell differentiation
Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.
positive regulation of developmental process
Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
positive regulation of cell differentiation
Any process that activates or increases the frequency, rate or extent of cell differentiation.
positive regulation of locomotion
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
positive regulation of behavior
Any process that activates or increases the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.
regulation of behavior
Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.
response to wounding
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
regulation of response to external stimulus
Any process that modulates the frequency, rate or extent of a response to an external stimulus.
positive regulation of response to external stimulus
Any process that activates, maintains or increases the rate of a response to an external stimulus.
taxis
The directed movement of a motile cell or organism in response to an external stimulus.
chemotaxis
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
regulation of macromolecule biosynthetic process
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of cellular biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
regulation of cellular biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
regulation of macromolecule biosynthetic process
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of gene expression
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.
cellular macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
cellular biopolymer metabolic process
The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
transcription
The synthesis of either RNA on a template of DNA or DNA on a template of RNA.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
osteoblast differentiation
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone.
regulation of cell differentiation
Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.
positive regulation of cell differentiation
Any process that activates or increases the frequency, rate or extent of cell differentiation.
positive regulation of cell differentiation
Any process that activates or increases the frequency, rate or extent of cell differentiation.
regulation of bone remodeling
Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.
regulation of osteoblast differentiation
Any process that modulates the frequency, rate or extent of osteoblast differentiation.
positive regulation of osteoblast differentiation
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
regulation of osteoblast differentiation
Any process that modulates the frequency, rate or extent of osteoblast differentiation.
ossification
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
positive regulation of chemotaxis
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
regulation of chemotaxis
Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
positive regulation of chemotaxis
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
positive regulation of chemotaxis
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
positive regulation of chemotaxis
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
positive regulation of response to external stimulus
Any process that activates, maintains or increases the rate of a response to an external stimulus.
regulation of chemotaxis
Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
positive regulation of behavior
Any process that activates or increases the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.
regulation of chemotaxis
Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
inflammatory response
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
taxis
The directed movement of a motile cell or organism in response to an external stimulus.
cellular biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
regulation of transcription
Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
regulation of transcription
Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
regulation of RNA metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
regulation of transcription
Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
transcription, DNA-dependent
The synthesis of RNA on a template of DNA.
regulation of transcription
Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
RNA metabolic process
The chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
cellular biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
RNA biosynthetic process
The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.
regulation of RNA metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
positive regulation of osteoblast differentiation
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
bone development
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
regulation of ossification
Any process that modulates the frequency, rate or extent of bone formation.
regulation of transcription, DNA-dependent
Any process that modulates the frequency, rate or extent of DNA-dependent transcription.
transcription
The synthesis of either RNA on a template of DNA or DNA on a template of RNA.
regulation of transcription, DNA-dependent
Any process that modulates the frequency, rate or extent of DNA-dependent transcription.
regulation of transcription from RNA polymerase II promoter
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
extracellular space
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
all
This term is the most general term possible
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
protein binding
Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
pattern binding
Interacting selectively with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
receptor binding
Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
carbohydrate binding
Interacting selectively with any carbohydrate.
cytokine activity
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
binding
The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
glycosaminoglycan binding
Interacting selectively with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues.
growth factor activity
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
heparin binding
Interacting selectively with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha1-4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
polysaccharide binding
Interacting selectively with any polysaccharide.
all
This term is the most general term possible
polysaccharide binding
Interacting selectively with any polysaccharide.
Id | Pvalue | ExpCount | Count | Size | Term |
---|---|---|---|---|---|
04060 | 2.123e-03 | 0.8984 | 7 | 115 | Cytokine-cytokine receptor interaction |
ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide (209612_s_at), score: 0.74 ADRA2Aadrenergic, alpha-2A-, receptor (209869_at), score: 0.59 ANGPTL4angiopoietin-like 4 (221009_s_at), score: 0.75 BMP2bone morphogenetic protein 2 (205289_at), score: 0.57 CCL7chemokine (C-C motif) ligand 7 (208075_s_at), score: 0.61 CXCL3chemokine (C-X-C motif) ligand 3 (207850_at), score: 0.71 CXCR7chemokine (C-X-C motif) receptor 7 (212977_at), score: 0.57 DKK2dickkopf homolog 2 (Xenopus laevis) (219908_at), score: 0.87 DPTdermatopontin (213068_at), score: 0.54 EGR2early growth response 2 (Krox-20 homolog, Drosophila) (205249_at), score: 0.64 EGR3early growth response 3 (206115_at), score: 0.68 FBXW7F-box and WD repeat domain containing 7 (218751_s_at), score: 0.62 FGF1fibroblast growth factor 1 (acidic) (205117_at), score: 0.56 FOSBFBJ murine osteosarcoma viral oncogene homolog B (202768_at), score: 1 GEMGTP binding protein overexpressed in skeletal muscle (204472_at), score: 0.61 HBEGFheparin-binding EGF-like growth factor (203821_at), score: 0.64 HIVEP2human immunodeficiency virus type I enhancer binding protein 2 (212642_s_at), score: 0.6 HLXH2.0-like homeobox (214438_at), score: 0.59 IL1RL1interleukin 1 receptor-like 1 (207526_s_at), score: 0.65 IL6interleukin 6 (interferon, beta 2) (205207_at), score: 0.56 IL8interleukin 8 (211506_s_at), score: 0.58 INSIG1insulin induced gene 1 (201627_s_at), score: 0.73 JHDM1Djumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (221778_at), score: 0.75 JMJD3jumonji domain containing 3, histone lysine demethylase (213146_at), score: 0.95 JUNDjun D proto-oncogene (203751_x_at), score: 0.61 KIAA1024KIAA1024 (215081_at), score: 0.56 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: 0.68 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: 0.7 LOH3CR2Aloss of heterozygosity, 3, chromosomal region 2, gene A (220244_at), score: 0.88 MAP2K3mitogen-activated protein kinase kinase 3 (207667_s_at), score: 0.62 MFAP4microfibrillar-associated protein 4 (212713_at), score: 0.57 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: 0.78 NR4A1nuclear receptor subfamily 4, group A, member 1 (202340_x_at), score: 0.58 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: 0.83 PDGFDplatelet derived growth factor D (219304_s_at), score: 0.64 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: 0.74 PPLperiplakin (203407_at), score: 0.73 RRADRas-related associated with diabetes (204802_at), score: 0.86 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: 0.59 SMOXspermine oxidase (210357_s_at), score: 0.68 SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: 0.58 SPSB1splA/ryanodine receptor domain and SOCS box containing 1 (219677_at), score: 0.57 THBDthrombomodulin (203887_s_at), score: 0.76 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: 0.58 VEGFAvascular endothelial growth factor A (211527_x_at), score: 0.73
Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
---|---|---|---|---|---|---|
1Twin.CEL | 1 | 2 | DS-twin | hgu133plus2 | Down | DS-twin 1 |
E-TABM-263-raw-cel-1515485851.cel | 11 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
E-TABM-263-raw-cel-1515486331.cel | 35 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
E-TABM-263-raw-cel-1515486231.cel | 30 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
ctrl b 08-03.CEL | 2 | 1 | DS-CC | hgu133a | none | DS-CC 2 |
ctrl a 08-03.CEL | 1 | 1 | DS-CC | hgu133a | none | DS-CC 1 |