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chromosome segregation

The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.

chromosome organization

A process that is carried out at the cellular level that results in the formation, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information.

mitotic sister chromatid segregation

The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.

cell cycle checkpoint

The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

mitotic cell cycle

Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.

M phase

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.

nuclear division

A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

DNA packaging

Any process by which DNA and associated proteins are formed into a compact, orderly structure.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism.

organelle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

microtubule-based process

Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.

microtubule-based movement

Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

spindle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

mitotic chromosome condensation

The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells.

mitotic chromosome movement towards spindle pole

The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

mitotic cell cycle spindle assembly checkpoint

A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly).

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

intracellular signaling cascade

A series of reactions within the cell that occur as a result of a single trigger reaction or compound.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cell cycle process

Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cellular component organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cellular component.

second-messenger-mediated signaling

A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell.

phosphoinositide-mediated signaling

A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

chromosome condensation

The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

cytoskeleton-dependent intracellular transport

The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.

spindle checkpoint

A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle.

intracellular transport

The directed movement of substances within a cell.

organelle fission

The creation of two or more organelles by division of one organelle.

chromosome localization

Any process by which a chromosome is transported to, or maintained in, a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of catalytic activity

Any process that modulates the activity of an enzyme.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cell division

The process resulting in the physical partitioning and separation of a cell into daughter cells.

establishment of chromosome localization

The directed movement of a chromosome to a specific location.

chromosome movement towards spindle pole

The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes.

interphase

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

regulation of ligase activity

Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.

regulation of ubiquitin-protein ligase activity

Any process that modulates the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

regulation of ubiquitin-protein ligase activity during mitotic cell cycle

A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle.

organelle localization

Any process by which an organelle is transported to, and/or maintained in, a specific location.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

establishment of organelle localization

The directed movement of an organelle to a specific location.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of molecular function

Any process that modulates the frequency, rate or extent of molecular functions. Molecular functions are elemental biological activities occurring at the molecular level, such as catalysis or binding.

all

This term is the most general term possible

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

intracellular transport

The directed movement of substances within a cell.

establishment of chromosome localization

The directed movement of a chromosome to a specific location.

mitotic chromosome movement towards spindle pole

The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis.

regulation of ubiquitin-protein ligase activity during mitotic cell cycle

A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

regulation of cell cycle process

Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

establishment of organelle localization

The directed movement of an organelle to a specific location.

chromosome movement towards spindle pole

The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes.

mitotic chromosome condensation

The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells.

mitotic chromosome movement towards spindle pole

The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

mitotic chromosome condensation

The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

chromosome condensation

The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

spindle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

mitotic sister chromatid segregation

The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

establishment of chromosome localization

The directed movement of a chromosome to a specific location.

microtubule-based movement

Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.

mitotic cell cycle spindle assembly checkpoint

A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly).

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

regulation of ubiquitin-protein ligase activity during mitotic cell cycle

A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle.

condensed chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosome, centromeric region

The region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

chromatin

The ordered and organized complex of DNA and protein that forms the chromosome.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

chromosome

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

microtubule organizing center

A region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

kinesin complex

Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

microtubule associated complex

Any multimeric complex connected to a microtubule.

spindle microtubule

Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

membrane-enclosed lumen

The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

all

This term is the most general term possible

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule associated complex

Any multimeric complex connected to a microtubule.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

microtubule organizing center

A region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow.

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

spindle microtubule

Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

microtubule organizing center

A region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

microtubule associated complex

Any multimeric complex connected to a microtubule.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

nucleotide binding

Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

motor activity

Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate.

microtubule motor activity

Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

nucleoside-triphosphatase activity

Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

ATP binding

Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

pyrophosphatase activity

Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

hydrolase activity, acting on acid anhydrides

Catalysis of the hydrolysis of any acid anhydride.

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.

purine nucleotide binding

Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate.

adenyl nucleotide binding

Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.

ribonucleotide binding

Interacting selectively with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

purine ribonucleotide binding

Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

adenyl ribonucleotide binding

Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

all

This term is the most general term possible

purine ribonucleotide binding

Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

adenyl ribonucleotide binding

Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0000280	1.190e-53	1.765	46 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CENPE, CENPF, CEP55, CIT, DLGAP5, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PLK1, PTTG1, SPAG5, SPC25, TIMELESS, TPX2, UBE2C	174	nuclear division
GO:0007067	1.190e-53	1.765	46 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CENPE, CENPF, CEP55, CIT, DLGAP5, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PLK1, PTTG1, SPAG5, SPC25, TIMELESS, TPX2, UBE2C	174	mitosis
GO:0000087	2.566e-53	1.795	46 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CENPE, CENPF, CEP55, CIT, DLGAP5, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PLK1, PTTG1, SPAG5, SPC25, TIMELESS, TPX2, UBE2C	177	M phase of mitotic cell cycle
GO:0048285	5.516e-53	1.826	46 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CENPE, CENPF, CEP55, CIT, DLGAP5, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PLK1, PTTG1, SPAG5, SPC25, TIMELESS, TPX2, UBE2C	180	organelle fission
GO:0022403	1.146e-51	2.911	51 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CDKN3, CENPE, CENPF, CEP55, CIT, DLGAP5, GTSE1, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PLK1, POLA1, PTTG1, SPAG5, SPC25, TACC3, TIMELESS, TPX2, TTK, UBE2C	287	cell cycle phase
GO:0000279	2.478e-51	2.343	48 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CENPE, CENPF, CEP55, CIT, DLGAP5, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PLK1, PTTG1, SPAG5, SPC25, TACC3, TIMELESS, TPX2, TTK, UBE2C	231	M phase
GO:0000278	5.818e-48	3.195	50 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CDKN3, CENPE, CENPF, CEP55, CIT, DLGAP5, GTSE1, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PLK1, POLA1, PTTG1, SPAG5, SPC25, TIMELESS, TPX2, TTK, UBE2C	315	mitotic cell cycle
GO:0022402	1.297e-44	4.006	51 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CDKN3, CENPE, CENPF, CEP55, CIT, DLGAP5, GTSE1, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PLK1, POLA1, PTTG1, SPAG5, SPC25, TACC3, TIMELESS, TPX2, TTK, UBE2C	395	cell cycle process
GO:0051301	1.044e-39	1.958	39 ASPM, AURKB, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CENPE, CENPF, CEP55, CIT, KIF11, KIF20B, KIF23, KNTC1, LIG1, MAD2L1, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PLK1, PTTG1, SPAG5, SPC25, TIMELESS, UBE2C	193	cell division
GO:0007049	2.625e-39	6.613	55 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CDKN3, CENPE, CENPF, CEP55, CIT, CKAP2, DLGAP5, GTSE1, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, LIG1, MAD2L1, MKI67, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PLK1, POLA1, PSRC1, PTTG1, SPAG5, SPC25, TACC3, TIMELESS, TPX2, TTK, UBE2C	652	cell cycle
GO:0006996	1.781e-29	9.088	53 ASF1B, ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CENPA, CENPE, CENPF, CEP55, CIT, DLGAP5, EZH2, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PLK1, PSRC1, PTTG1, SPAG5, SPC25, TACC3, TIMELESS, TPX2, TTK, UBE2C	896	organelle organization
GO:0007017	1.813e-18	1.369	22 AURKA, BUB1B, CENPE, GTSE1, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, NDC80, NEK2, NUSAP1, PSRC1, SPAG5, TACC3, TTK, UBE2C	135	microtubule-based process
GO:0016043	7.455e-17	16.35	53 ASF1B, ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CENPA, CENPE, CENPF, CEP55, CIT, DLGAP5, EZH2, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PLK1, PSRC1, PTTG1, SPAG5, SPC25, TACC3, TIMELESS, TPX2, TTK, UBE2C	1612	cellular component organization
GO:0007346	7.795e-11	0.9027	14 BUB1, BUB1B, CCNA2, CDC25C, CENPF, DLGAP5, GTSE1, KIF20B, KNTC1, MAD2L1, NEK2, NUSAP1, TTK, UBE2C	89	regulation of mitotic cell cycle
GO:0000226	2.307e-10	0.781	13 AURKA, BUB1B, KIF11, KIF23, KIF2C, NDC80, NEK2, NUSAP1, PSRC1, SPAG5, TACC3, TTK, UBE2C	77	microtubule cytoskeleton organization
GO:0007051	6.130e-10	0.2536	9 AURKA, BUB1B, KIF11, KIF23, NDC80, SPAG5, TACC3, TTK, UBE2C	25	spindle organization
GO:0007018	6.505e-09	0.6187	11 CENPE, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A	61	microtubule-based movement
GO:0007059	7.975e-09	0.4666	10 CENPE, CENPF, DLGAP5, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1, PTTG1	46	chromosome segregation
GO:0000070	1.341e-08	0.2333	8 CENPE, DLGAP5, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1	23	mitotic sister chromatid segregation
GO:0000819	1.952e-08	0.2434	8 CENPE, DLGAP5, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1	24	sister chromatid segregation
GO:0030705	3.291e-08	0.7201	11 CENPE, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A	71	cytoskeleton-dependent intracellular transport
GO:0007093	1.304e-07	0.3043	8 BUB1, BUB1B, CCNA2, CENPF, GTSE1, KNTC1, MAD2L1, TTK	30	mitotic cell cycle checkpoint
GO:0051726	2.039e-07	2.657	17 BUB1, BUB1B, CCNA2, CDC25C, CDKN3, CENPF, DLGAP5, GTSE1, KIF20B, KNTC1, MAD2L1, NEK2, NUSAP1, TACC3, TIMELESS, TTK, UBE2C	262	regulation of cell cycle
GO:0010564	1.008e-05	0.5274	8 CDC25C, DLGAP5, KIF20B, KNTC1, NEK2, NUSAP1, TIMELESS, UBE2C	52	regulation of cell cycle process
GO:0007088	1.331e-05	0.3651	7 CDC25C, DLGAP5, KIF20B, KNTC1, NEK2, NUSAP1, UBE2C	36	regulation of mitosis
GO:0000075	1.522e-05	0.5578	8 BUB1, BUB1B, CCNA2, CENPF, GTSE1, KNTC1, MAD2L1, TTK	55	cell cycle checkpoint
GO:0007076	1.678e-05	0.1217	5 NCAPD2, NCAPG, NCAPG2, NCAPH, NUSAP1	12	mitotic chromosome condensation
GO:0030261	5.480e-05	0.1521	5 NCAPD2, NCAPG, NCAPG2, NCAPH, NUSAP1	15	chromosome condensation
GO:0007010	2.393e-04	2.586	13 AURKA, BUB1B, KIF11, KIF23, KIF2C, NDC80, NEK2, NUSAP1, PSRC1, SPAG5, TACC3, TTK, UBE2C	255	cytoskeleton organization
GO:0006323	3.919e-04	0.6187	7 ASF1B, CENPA, NCAPD2, NCAPG, NCAPG2, NCAPH, NUSAP1	61	DNA packaging
GO:0051276	4.855e-04	2.779	13 ASF1B, CENPA, CENPE, CENPF, DLGAP5, EZH2, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1, PTTG1	274	chromosome organization
GO:0050000	6.281e-04	0.04057	3 CENPE, CENPF, DLGAP5	4	chromosome localization
GO:0051303	6.281e-04	0.04057	3 CENPE, CENPF, DLGAP5	4	establishment of chromosome localization
GO:0007094	1.388e-03	0.05071	3 BUB1, CENPF, TTK	5	mitotic cell cycle spindle assembly checkpoint
GO:0031577	1.388e-03	0.05071	3 BUB1, CENPF, TTK	5	spindle checkpoint
GO:0051439	4.666e-03	0.6491	6 BUB1B, CCNB1, CDC20, MAD2L1, PLK1, UBE2C	64	regulation of ubiquitin-protein ligase activity during mitotic cell cycle
GO:0051438	6.624e-03	0.6998	6 BUB1B, CCNB1, CDC20, MAD2L1, PLK1, UBE2C	69	regulation of ubiquitin-protein ligase activity
GO:0051640	7.459e-03	0.4463	5 CENPE, CENPF, DLGAP5, NUSAP1, TACC3	44	organelle localization
GO:0051340	8.018e-03	0.7303	6 BUB1B, CCNB1, CDC20, MAD2L1, PLK1, UBE2C	72	regulation of ligase activity
GO:0048015	8.871e-03	0.4666	5 AURKA, BUB1B, NDC80, SPAG5, UBE2C	46	phosphoinositide-mediated signaling
GO:0051325	9.048e-03	0.7505	6 CDC25C, CDKN3, CENPF, GTSE1, POLA1, TIMELESS	74	interphase
GO:0007079	9.518e-03	0.02029	2 CENPE, DLGAP5	2	mitotic chromosome movement towards spindle pole
GO:0051305	9.518e-03	0.02029	2 CENPE, DLGAP5	2	chromosome movement towards spindle pole
GO:0008283	1.166e-02	5.731	16 BUB1, BUB1B, CDC25B, CDC25C, CDKN3, CENPF, DLGAP5, KIF15, KIF2C, MKI67, PLK1, POLA1, TACC3, TIMELESS, TPX2, TTK	565	cell proliferation
GO:0007052	1.641e-02	0.1217	3 KIF11, KIF23, TTK	12	mitotic spindle organization
GO:0031145	2.083e-02	0.5883	5 BUB1B, CCNB1, CDC20, MAD2L1, UBE2C	58	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006271	2.190e-02	0.03043	2 POLA1, RFC3	3	DNA strand elongation during DNA replication
GO:0034508	2.190e-02	0.03043	2 CENPE, CENPF	3	centromere complex assembly
GO:0051299	2.190e-02	0.03043	2 KIF11, NEK2	3	centrosome separation
GO:0051310	2.190e-02	0.03043	2 CENPE, CENPF	3	metaphase plate congression
GO:0051382	2.190e-02	0.03043	2 CENPE, CENPF	3	kinetochore assembly
GO:0051383	2.190e-02	0.03043	2 CENPE, CENPF	3	kinetochore organization
GO:0045840	2.367e-02	0.142	3 DLGAP5, NUSAP1, UBE2C	14	positive regulation of mitosis
GO:0051656	3.141e-02	0.3753	4 CENPE, CENPF, DLGAP5, NUSAP1	37	establishment of organelle localization
GO:0022616	3.577e-02	0.04057	2 POLA1, RFC3	4	DNA strand elongation
GO:0051329	4.061e-02	0.7201	5 CDC25C, CDKN3, CENPF, GTSE1, POLA1	71	interphase of mitotic cell cycle
GO:0051649	4.350e-02	6.055	15 CENPE, CENPF, DLGAP5, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, NUSAP1, TACC3	597	establishment of localization in cell
GO:0000085	4.950e-02	0.05071	2 CENPF, GTSE1	5	G2 phase of mitotic cell cycle
GO:0051319	4.950e-02	0.05071	2 CENPF, GTSE1	5	G2 phase

Id	Pvalue	ExpCount	Count	Size	Term
GO:0015630	1.537e-22	3.006	32 AURKA, AURKB, BUB1, BUB1B, C18orf24, CCNB1, CCNB2, CDC20, CDC25B, CENPE, CENPF, CKAP2, DLGAP5, GTSE1, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, NEK2, NUSAP1, PLK1, PSRC1, SPAG5, TPX2, TTK	322	microtubule cytoskeleton
GO:0000775	9.633e-22	0.588	19 AURKB, BUB1, BUB1B, C18orf24, C21orf45, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, KIF22, KIF2C, KNTC1, MAD2L1, NDC80, OIP5, SPAG5, SPC25	63	chromosome, centromeric region
GO:0005694	7.112e-21	2.315	28 ASF1B, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, HMGB3, KIF22, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPH, NDC80, OIP5, POLA1, RFC3, SPAG5, SPC25, TIMELESS	248	chromosome
GO:0044427	7.613e-21	1.848	26 ASF1B, AURKB, BUB1, BUB1B, C18orf24, C21orf45, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, KIF22, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPH, NDC80, OIP5, POLA1, RFC3, SPAG5, SPC25, TIMELESS	198	chromosomal part
GO:0043228	2.756e-20	12.6	51 ASF1B, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNB1, CCNB2, CDC20, CDC25B, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, CKAP2, DLGAP5, GTSE1, HMGB3, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, MAD2L1, MKI67, NCAPD2, NCAPG, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PLK1, POLA1, PSRC1, RFC3, SPAG5, SPC25, TIMELESS, TPX2, TTK	1350	non-membrane-bounded organelle
GO:0043232	2.756e-20	12.6	51 ASF1B, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNB1, CCNB2, CDC20, CDC25B, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, CKAP2, DLGAP5, GTSE1, HMGB3, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, MAD2L1, MKI67, NCAPD2, NCAPG, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PLK1, POLA1, PSRC1, RFC3, SPAG5, SPC25, TIMELESS, TPX2, TTK	1350	intracellular non-membrane-bounded organelle
GO:0005819	1.062e-19	0.7467	19 AURKA, AURKB, BUB1, BUB1B, C18orf24, CDC20, CENPE, CENPF, DLGAP5, KIF11, KIF14, KIF15, KIF23, KIF4A, KNTC1, PSRC1, SPAG5, TPX2, TTK	80	spindle
GO:0044430	3.673e-18	3.92	31 AURKA, AURKB, BUB1, BUB1B, C18orf24, CCNB1, CDC20, CDC25B, CENPE, CENPF, CKAP2, DLGAP5, GTSE1, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, NEK2, NUSAP1, PLK1, PSRC1, SPAG5, TPX2, TTK	420	cytoskeletal part
GO:0000776	2.696e-14	0.4294	13 BUB1, BUB1B, C18orf24, CENPA, CENPE, CENPF, CENPM, KIF22, KNTC1, MAD2L1, NDC80, SPAG5, SPC25	46	kinetochore
GO:0005856	6.264e-14	6.524	33 AURKA, AURKB, BUB1, BUB1B, C18orf24, CCNB1, CCNB2, CDC20, CDC25B, CENPE, CENPF, CKAP2, DLGAP5, GTSE1, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, NCAPH, NEK2, NUSAP1, PLK1, PSRC1, SPAG5, TPX2, TTK	699	cytoskeleton
GO:0000793	1.248e-13	0.616	14 BUB1, BUB1B, C18orf24, CENPA, CENPE, CENPF, CENPM, KNTC1, NCAPD2, NCAPG, NCAPH, NDC80, SPAG5, SPC25	66	condensed chromosome
GO:0000777	1.031e-12	0.3174	11 BUB1, BUB1B, C18orf24, CENPA, CENPE, CENPF, CENPM, KNTC1, NDC80, SPAG5, SPC25	34	condensed chromosome kinetochore
GO:0000779	1.031e-12	0.3174	11 BUB1, BUB1B, C18orf24, CENPA, CENPE, CENPF, CENPM, KNTC1, NDC80, SPAG5, SPC25	34	condensed chromosome, centromeric region
GO:0005874	3.908e-11	1.381	16 CENPE, CKAP2, GTSE1, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, NUSAP1, SPAG5	148	microtubule
GO:0005634	1.104e-10	28.85	59 ASF1B, ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, DEPDC1, DLGAP5, EZH2, FOXM1, GINS2, HJURP, HMGB3, KIF11, KIF14, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LIG1, MAD2L1, MKI67, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEIL3, NEK2, NUSAP1, OIP5, PLK1, POLA1, PTTG1, RFC3, RNASEH2A, SPC25, TIMELESS, TPX2, TRIP13, UBE2C	3091	nucleus
GO:0044446	8.959e-10	25.16	54 ASF1B, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CDC20, CDC25B, CDC25C, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, CKAP2, DLGAP5, EZH2, GTSE1, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LIG1, MAD2L1, MKI67, NCAPD2, NCAPG, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PLK1, POLA1, PSRC1, RFC3, SPAG5, SPC25, TIMELESS, TPX2, TTK, UBE2C	2695	intracellular organelle part
GO:0044422	1.051e-09	25.25	54 ASF1B, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CDC20, CDC25B, CDC25C, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, CKAP2, DLGAP5, EZH2, GTSE1, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LIG1, MAD2L1, MKI67, NCAPD2, NCAPG, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PLK1, POLA1, PSRC1, RFC3, SPAG5, SPC25, TIMELESS, TPX2, TTK, UBE2C	2705	organelle part
GO:0005875	1.927e-09	0.616	11 CENPE, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A	66	microtubule associated complex
GO:0000922	1.517e-06	0.1867	6 BUB1, CENPF, DLGAP5, KIF11, KNTC1, TPX2	20	spindle pole
GO:0043234	1.710e-06	11.15	31 BIRC5, BUB1, BUB1B, C18orf24, CDCA8, CENPA, CENPE, CENPF, CENPM, EZH2, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPH, NDC80, NEK2, POLA1, RFC3, SPAG5, SPC25	1195	protein complex
GO:0000940	4.734e-05	0.028	3 BUB1B, CENPE, CENPF	3	outer kinetochore of condensed chromosome
GO:0043229	6.022e-05	48.98	67 ASF1B, ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, CKAP2, DEPDC1, DLGAP5, EZH2, FOXM1, GINS2, GTSE1, HJURP, HMGB3, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LIG1, MAD2L1, MKI67, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEIL3, NEK2, NUSAP1, OIP5, PLK1, POLA1, PSRC1, PTTG1, RFC3, RNASEH2A, SPAG5, SPC25, TIMELESS, TPX2, TRIP13, TTK, UBE2C	5248	intracellular organelle
GO:0043226	6.074e-05	48.99	67 ASF1B, ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, CKAP2, DEPDC1, DLGAP5, EZH2, FOXM1, GINS2, GTSE1, HJURP, HMGB3, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LIG1, MAD2L1, MKI67, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEIL3, NEK2, NUSAP1, OIP5, PLK1, POLA1, PSRC1, PTTG1, RFC3, RNASEH2A, SPAG5, SPC25, TIMELESS, TPX2, TRIP13, TTK, UBE2C	5249	organelle
GO:0005871	1.212e-04	0.1027	4 KIF11, KIF15, KIF23, KIF2C	11	kinesin complex
GO:0005622	1.471e-04	59.89	73 ARHGAP11A, ASF1B, ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CBR3, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, CIT, CKAP2, DEPDC1, DLGAP5, EZH2, FOXM1, GINS2, GTSE1, HJURP, HMGB3, HMMR, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LIG1, MAD2L1, MKI67, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEIL3, NEK2, NUSAP1, OIP5, PLK1, POLA1, PSRC1, PTTG1, RFC3, RNASEH2A, SPAG5, SPC25, TACC3, TIMELESS, TPX2, TRIP13, TTK, UBE2C	6416	intracellular
GO:0044424	1.610e-04	57.96	72 ASF1B, ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CBR3, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA3, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, CIT, CKAP2, DEPDC1, DLGAP5, EZH2, FOXM1, GINS2, GTSE1, HJURP, HMGB3, HMMR, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LIG1, MAD2L1, MKI67, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEIL3, NEK2, NUSAP1, OIP5, PLK1, POLA1, PSRC1, PTTG1, RFC3, RNASEH2A, SPAG5, SPC25, TACC3, TIMELESS, TPX2, TRIP13, TTK, UBE2C	6210	intracellular part
GO:0032991	3.490e-04	14.38	31 BIRC5, BUB1, BUB1B, C18orf24, CDCA8, CENPA, CENPE, CENPF, CENPM, EZH2, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, MAD2L1, NCAPD2, NCAPG, NCAPH, NDC80, NEK2, POLA1, RFC3, SPAG5, SPC25	1541	macromolecular complex
GO:0005815	5.948e-04	1.456	9 AURKA, BUB1, CCNB1, CDC25B, DLGAP5, KIF15, KIF20B, NEK2, PLK1	156	microtubule organizing center
GO:0000796	6.860e-04	0.056	3 NCAPD2, NCAPG, NCAPH	6	condensin complex
GO:0005876	8.484e-04	0.168	4 KIF11, KIF4A, KNTC1, SPAG5	18	spindle microtubule
GO:0005813	2.751e-03	1.409	8 AURKA, CCNB1, CDC25B, DLGAP5, KIF15, KIF20B, NEK2, PLK1	151	centrosome
GO:0000785	5.312e-03	0.8214	6 ASF1B, CENPA, CENPF, OIP5, POLA1, TIMELESS	88	chromatin
GO:0044428	5.529e-03	10.58	23 BIRC5, BUB1, BUB1B, CCNA2, CCNB1, CDC20, CDC25B, CDC25C, CENPF, EZH2, KIF20A, KIF20B, KIF23, KIF4A, LIG1, MKI67, NCAPD2, OIP5, PLK1, POLA1, RFC3, TIMELESS, UBE2C	1134	nuclear part
GO:0005654	6.504e-03	5.32	15 CCNA2, CCNB1, CDC20, CDC25B, CDC25C, EZH2, KIF20A, KIF20B, KIF23, LIG1, OIP5, PLK1, POLA1, RFC3, UBE2C	570	nucleoplasm
GO:0043231	7.875e-03	44.48	59 ASF1B, ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, DEPDC1, DLGAP5, EZH2, FOXM1, GINS2, HJURP, HMGB3, KIF11, KIF14, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LIG1, MAD2L1, MKI67, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEIL3, NEK2, NUSAP1, OIP5, PLK1, POLA1, PTTG1, RFC3, RNASEH2A, SPC25, TIMELESS, TPX2, TRIP13, UBE2C	4765	intracellular membrane-bounded organelle
GO:0043227	7.981e-03	44.5	59 ASF1B, ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25B, CDC25C, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, DEPDC1, DLGAP5, EZH2, FOXM1, GINS2, HJURP, HMGB3, KIF11, KIF14, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LIG1, MAD2L1, MKI67, NCAPD2, NCAPG, NCAPG2, NCAPH, NDC80, NEIL3, NEK2, NUSAP1, OIP5, PLK1, POLA1, PTTG1, RFC3, RNASEH2A, SPC25, TIMELESS, TPX2, TRIP13, UBE2C	4767	membrane-bounded organelle
GO:0031981	8.348e-03	8.074	19 BIRC5, CCNA2, CCNB1, CDC20, CDC25B, CDC25C, CENPF, EZH2, KIF20A, KIF20B, KIF23, KIF4A, LIG1, MKI67, OIP5, PLK1, POLA1, RFC3, UBE2C	865	nuclear lumen

Id	Pvalue	ExpCount	Count	Size	Term
GO:0003777	2.427e-10	0.3158	11 CENPE, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A	37	microtubule motor activity
GO:0003774	6.184e-08	0.6061	11 CENPE, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A	71	motor activity
GO:0005524	4.271e-06	6.906	25 AURKA, AURKB, BUB1, BUB1B, CENPE, CIT, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MKI67, NEK2, PLK1, PLK4, TPX2, TRIP13, TTK, UBE2C	809	ATP binding
GO:0032559	5.022e-06	6.982	25 AURKA, AURKB, BUB1, BUB1B, CENPE, CIT, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MKI67, NEK2, PLK1, PLK4, TPX2, TRIP13, TTK, UBE2C	818	adenyl ribonucleotide binding
GO:0030554	1.176e-05	7.375	25 AURKA, AURKB, BUB1, BUB1B, CENPE, CIT, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MKI67, NEK2, PLK1, PLK4, TPX2, TRIP13, TTK, UBE2C	864	adenyl nucleotide binding
GO:0032553	1.292e-04	8.638	25 AURKA, AURKB, BUB1, BUB1B, CENPE, CIT, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MKI67, NEK2, PLK1, PLK4, TPX2, TRIP13, TTK, UBE2C	1012	ribonucleotide binding
GO:0032555	1.292e-04	8.638	25 AURKA, AURKB, BUB1, BUB1B, CENPE, CIT, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MKI67, NEK2, PLK1, PLK4, TPX2, TRIP13, TTK, UBE2C	1012	purine ribonucleotide binding
GO:0000166	1.913e-04	10.88	28 AURKA, AURKB, BUB1, BUB1B, CENPE, CIT, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MKI67, NEK2, PBK, PLK1, PLK4, POLA1, RFC3, TPX2, TRIP13, TTK, UBE2C	1275	nucleotide binding
GO:0017076	2.612e-04	9.048	25 AURKA, AURKB, BUB1, BUB1B, CENPE, CIT, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MKI67, NEK2, PLK1, PLK4, TPX2, TRIP13, TTK, UBE2C	1060	purine nucleotide binding
GO:0004674	1.055e-02	2.296	10 AURKA, AURKB, BUB1, BUB1B, CIT, NEK2, PBK, PLK1, PLK4, TTK	269	protein serine/threonine kinase activity
GO:0017111	1.120e-02	3.85	13 CENPE, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, RFC3, TRIP13	451	nucleoside-triphosphatase activity
GO:0016462	1.532e-02	4.012	13 CENPE, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, RFC3, TRIP13	470	pyrophosphatase activity
GO:0016818	1.580e-02	4.029	13 CENPE, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, RFC3, TRIP13	472	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016817	1.601e-02	4.038	13 CENPE, KIF11, KIF14, KIF15, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, RFC3, TRIP13	473	hydrolase activity, acting on acid anhydrides

Id	Pvalue	ExpCount	Count	Size	Term
04110	7.682e-09	0.755	11 BUB1, BUB1B, CCNA2, CCNB1, CCNB2, CDC20, CDC25B, CDC25C, MAD2L1, PLK1, PTTG1	98	Cell cycle
03030	8.821e-03	0.2542	4 LIG1, POLA1, RFC3, RNASEH2A	33	DNA replication

No enriched terms

No enriched terms

Entrez genes

ARHGAP11ARho GTPase activating protein 11A (204492_at), score: 0.84 ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae) (218115_at), score: 0.93 ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila) (219918_s_at), score: 0.89 AURKAaurora kinase A (208079_s_at), score: 0.86 AURKBaurora kinase B (209464_at), score: 0.97 BIRC5baculoviral IAP repeat-containing 5 (202095_s_at), score: 0.88 BUB1budding uninhibited by benzimidazoles 1 homolog (yeast) (209642_at), score: 0.95 BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast) (203755_at), score: 0.92 C18orf24chromosome 18 open reading frame 24 (217640_x_at), score: 0.86 C21orf45chromosome 21 open reading frame 45 (219004_s_at), score: 0.85 CBR3carbonyl reductase 3 (205379_at), score: 0.82 CCDC15coiled-coil domain containing 15 (220466_at), score: 0.84 CCNA2cyclin A2 (203418_at), score: 0.9 CCNB1cyclin B1 (214710_s_at), score: 0.83 CCNB2cyclin B2 (202705_at), score: 0.9 CCNFcyclin F (204826_at), score: 0.97 CDC20cell division cycle 20 homolog (S. cerevisiae) (202870_s_at), score: 0.93 CDC25Bcell division cycle 25 homolog B (S. pombe) (201853_s_at), score: 0.83 CDC25Ccell division cycle 25 homolog C (S. pombe) (205167_s_at), score: 0.83 CDCA3cell division cycle associated 3 (221436_s_at), score: 0.94 CDCA8cell division cycle associated 8 (221520_s_at), score: 0.94 CDKN3cyclin-dependent kinase inhibitor 3 (209714_s_at), score: 0.9 CENPAcentromere protein A (204962_s_at), score: 0.92 CENPEcentromere protein E, 312kDa (205046_at), score: 1 CENPFcentromere protein F, 350/400ka (mitosin) (207828_s_at), score: 0.98 CENPIcentromere protein I (214804_at), score: 0.86 CENPMcentromere protein M (218741_at), score: 0.82 CEP55centrosomal protein 55kDa (218542_at), score: 0.84 CITcitron (rho-interacting, serine/threonine kinase 21) (212801_at), score: 0.89 CKAP2cytoskeleton associated protein 2 (218252_at), score: 0.88 DEPDC1DEP domain containing 1 (220295_x_at), score: 0.88 DLGAP5discs, large (Drosophila) homolog-associated protein 5 (203764_at), score: 0.87 EZH2enhancer of zeste homolog 2 (Drosophila) (203358_s_at), score: 0.86 FAM64Afamily with sequence similarity 64, member A (221591_s_at), score: 0.94 FOXM1forkhead box M1 (202580_x_at), score: 0.9 GINS2GINS complex subunit 2 (Psf2 homolog) (221521_s_at), score: 0.83 GTSE1G-2 and S-phase expressed 1 (204318_s_at), score: 0.94 HJURPHolliday junction recognition protein (218726_at), score: 1 HMGB3high-mobility group box 3 (203744_at), score: 0.85 HMMRhyaluronan-mediated motility receptor (RHAMM) (207165_at), score: 0.89 KIF11kinesin family member 11 (204444_at), score: 0.9 KIF14kinesin family member 14 (206364_at), score: 0.85 KIF15kinesin family member 15 (219306_at), score: 0.95 KIF18Bkinesin family member 18B (222039_at), score: 0.96 KIF20Akinesin family member 20A (218755_at), score: 0.89 KIF20Bkinesin family member 20B (205235_s_at), score: 0.94 KIF22kinesin family member 22 (202183_s_at), score: 0.89 KIF23kinesin family member 23 (204709_s_at), score: 0.82 KIF2Ckinesin family member 2C (209408_at), score: 0.92 KIF4Akinesin family member 4A (218355_at), score: 0.95 KNTC1kinetochore associated 1 (206316_s_at), score: 0.87 LIG1ligase I, DNA, ATP-dependent (202726_at), score: 0.86 MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast) (203362_s_at), score: 0.82 MKI67antigen identified by monoclonal antibody Ki-67 (212022_s_at), score: 0.99 NCAPD2non-SMC condensin I complex, subunit D2 (201774_s_at), score: 0.89 NCAPGnon-SMC condensin I complex, subunit G (218663_at), score: 0.87 NCAPG2non-SMC condensin II complex, subunit G2 (219588_s_at), score: 0.87 NCAPHnon-SMC condensin I complex, subunit H (212949_at), score: 0.89 NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae) (204162_at), score: 0.88 NEIL3nei endonuclease VIII-like 3 (E. coli) (219502_at), score: 0.84 NEK2NIMA (never in mitosis gene a)-related kinase 2 (204641_at), score: 0.92 NUSAP1nucleolar and spindle associated protein 1 (218039_at), score: 0.91 OIP5Opa interacting protein 5 (213599_at), score: 0.89 PBKPDZ binding kinase (219148_at), score: 0.86 PLK1polo-like kinase 1 (Drosophila) (202240_at), score: 0.94 PLK4polo-like kinase 4 (Drosophila) (204887_s_at), score: 0.82 POLA1polymerase (DNA directed), alpha 1, catalytic subunit (204835_at), score: 0.84 PSRC1proline/serine-rich coiled-coil 1 (201896_s_at), score: 0.85 PTTG1pituitary tumor-transforming 1 (203554_x_at), score: 0.88 RFC3replication factor C (activator 1) 3, 38kDa (204127_at), score: 0.83 RNASEH2Aribonuclease H2, subunit A (203022_at), score: 0.9 SPAG5sperm associated antigen 5 (203145_at), score: 0.95 SPC25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) (209891_at), score: 0.92 TACC3transforming, acidic coiled-coil containing protein 3 (218308_at), score: 0.95 TIMELESStimeless homolog (Drosophila) (203046_s_at), score: 0.84 TMEM194Atransmembrane protein 194A (212621_at), score: 0.83 TPX2TPX2, microtubule-associated, homolog (Xenopus laevis) (210052_s_at), score: 0.94 TRIP13thyroid hormone receptor interactor 13 (204033_at), score: 0.85 TTKTTK protein kinase (204822_at), score: 0.94 UBE2Cubiquitin-conjugating enzyme E2C (202954_at), score: 0.91

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
E-TABM-263-raw-cel-1515485851.cel	11	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515485811.cel	9	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486351.cel	36	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486231.cel	30	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515485891.cel	13	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515485651.cel	1	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486331.cel	35	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486271.cel	32	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486291.cel	33	6	Cycle	hgu133a2	none	Cycle 1
E-GEOD-3860-raw-cel-1561690376.cel	13	5	HGPS	hgu133a	HGPS	AG11513
E-TABM-263-raw-cel-1515486371.cel	37	6	Cycle	hgu133a2	none	Cycle 1
9118_CNTL.CEL	11	8	WBS	hgu133plus2	none	WBS 1
47B.CEL	4	3	DS-mosaic	hgu133plus2	Down mosaic	DS-mosaic 4
E-GEOD-3860-raw-cel-1561690336.cel	9	5	HGPS	hgu133a	HGPS	AG10750
E-GEOD-3860-raw-cel-1561690199.cel	1	5	HGPS	hgu133a	none	GM0316B
6089_CNTL.CEL	9	8	WBS	hgu133plus2	none	WBS 1
46A.CEL	1	3	DS-mosaic	hgu133plus2	none	DS-mosaic 1
E-TABM-263-raw-cel-1515485711.cel	4	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486031.cel	20	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486251.cel	31	6	Cycle	hgu133a2	none	Cycle 1
5CTwin.CEL	5	2	DS-twin	hgu133plus2	Down	DS-twin 5
E-GEOD-3860-raw-cel-1561690272.cel	7	5	HGPS	hgu133a	HGPS	AG11498
E-TABM-263-raw-cel-1515486211.cel	29	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515485931.cel	15	6	Cycle	hgu133a2	none	Cycle 1
E-GEOD-3860-raw-cel-1561690344.cel	10	5	HGPS	hgu133a	none	GM00038C
E-GEOD-3860-raw-cel-1561690392.cel	14	5	HGPS	hgu133a	none	GMO8398C
E-TABM-263-raw-cel-1515485871.cel	12	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486151.cel	26	6	Cycle	hgu133a2	none	Cycle 1
4319_WBS.CEL	5	8	WBS	hgu133plus2	WBS	WBS 1
D890_WBS.CEL	13	8	WBS	hgu133plus2	WBS	WBS 1
E-TABM-263-raw-cel-1515485691.cel	3	6	Cycle	hgu133a2	none	Cycle 1
E-GEOD-4219-raw-cel-1311956321.cel	9	7	Sph-mono	hgu133plus2	none	Sph-mon 1
E-GEOD-3860-raw-cel-1561690352.cel	11	5	HGPS	hgu133a	HGPS	AG11498
46C.CEL	3	3	DS-mosaic	hgu133plus2	none	DS-mosaic 3
E-GEOD-3860-raw-cel-1561690472.cel	17	5	HGPS	hgu133a	none	GM00038C
E-GEOD-4219-raw-cel-1311956614.cel	18	7	Sph-mono	hgu133plus2	none	Sph-mon 1
F055_WBS.CEL	14	8	WBS	hgu133plus2	WBS	WBS 1