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DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

cell cycle checkpoint

The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.

S phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

mitotic cell cycle

Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.

M phase

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.

nuclear division

A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.

DNA synthesis during DNA repair

Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

regulation of protein amino acid phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

positive regulation of protein amino acid phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

DNA-dependent DNA replication

The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

nucleotide-excision repair

In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).

nucleotide-excision repair, DNA gap filling

Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes.

protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

protein amino acid phosphorylation

The process of introducing a phosphate group on to a protein.

phosphorus metabolic process

The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).

phosphate metabolic process

The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

response to DNA damage stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

organelle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

mitotic cell cycle spindle assembly checkpoint

A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly).

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

positive regulation of phosphorus metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

positive regulation of macromolecule metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cellular component organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cellular component.

phosphorylation

The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

regulation of phosphate metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of protein modification process

Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

spindle checkpoint

A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle.

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular response to DNA damage stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

regulation of phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

biopolymer modification

The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer, resulting in a change in its properties.

post-translational protein modification

The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

positive regulation of phosphate metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

organelle fission

The creation of two or more organelles by division of one organelle.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of phosphorus metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.

cell division

The process resulting in the physical partitioning and separation of a cell into daughter cells.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

interphase

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

interphase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

all

This term is the most general term possible

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

positive regulation of macromolecule metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of macromolecule metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

positive regulation of phosphorus metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

regulation of phosphorus metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

cellular response to DNA damage stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of phosphorus metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

regulation of phosphate metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

positive regulation of phosphate metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

S phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

interphase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

positive regulation of phosphate metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

regulation of protein modification process

Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

DNA synthesis during DNA repair

Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template.

regulation of phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

mitotic cell cycle spindle assembly checkpoint

A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly).

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

positive regulation of protein amino acid phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

positive regulation of protein amino acid phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

regulation of protein amino acid phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

protein amino acid phosphorylation

The process of introducing a phosphate group on to a protein.

nucleotide-excision repair, DNA gap filling

Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes.

regulation of protein amino acid phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

positive regulation of protein amino acid phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

condensed chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosome, centromeric region

The region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

chromatin

The ordered and organized complex of DNA and protein that forms the chromosome.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

replication fork

The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

chromosome

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

membrane-enclosed lumen

The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

protein-DNA complex

A macromolecular complex containing both protein and DNA molecules.

nuclear periphery

The portion of the nuclear lumen proximal to the inner nuclear membrane.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

all

This term is the most general term possible

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

nuclear periphery

The portion of the nuclear lumen proximal to the inner nuclear membrane.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

protein binding

Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

receptor binding

Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

all

This term is the most general term possible

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022403	4.311e-14	4.288	29 AURKB, BLM, BRCA2, BUB1, C18orf24, CCNA2, CDC7, CDCA8, CENPF, DDX11, DSN1, ERCC6L, HELLS, IL1B, KIF11, KIF15, KIF22, MAD2L1, NCAPD2, OIP5, POLA1, POLD1, PSMC3IP, SMC2, TACC3, TIMELESS, TPX2, TTK, WEE1	287	cell cycle phase
GO:0000279	1.577e-12	3.451	25 AURKB, BRCA2, BUB1, C18orf24, CCNA2, CDCA8, CENPF, DDX11, DSN1, ERCC6L, HELLS, IL1B, KIF11, KIF15, KIF22, MAD2L1, NCAPD2, OIP5, PSMC3IP, SMC2, TACC3, TIMELESS, TPX2, TTK, WEE1	231	M phase
GO:0006260	7.784e-12	2.704	22 AREG, BLM, BRCA2, CDC7, CHAF1A, DTL, GINS1, GINS2, GINS3, HMGB2, MCM10, MCM2, MCM5, MCM7, ORC6L, POLA1, POLD1, POLD3, POLE2, PRIM1, RFC3, RNASEH2A	181	DNA replication
GO:0007049	2.157e-11	9.741	38 AURKB, BARD1, BLM, BMP2, BRCA2, BUB1, C18orf24, CCNA2, CDC7, CDCA8, CENPF, CHAF1A, CKAP2, DDX11, DSN1, E2F8, ERCC6L, HELLS, IL1B, KIF11, KIF15, KIF22, MAD2L1, MCM2, MCM7, NCAPD2, OIP5, POLA1, POLD1, PSMC3IP, SMC2, TACC3, TIMELESS, TP53BP2, TPX2, TTK, TXNIP, WEE1	652	cell cycle
GO:0022402	2.409e-11	5.901	30 AURKB, BARD1, BLM, BRCA2, BUB1, C18orf24, CCNA2, CDC7, CDCA8, CENPF, DDX11, DSN1, ERCC6L, HELLS, IL1B, KIF11, KIF15, KIF22, MAD2L1, NCAPD2, OIP5, POLA1, POLD1, PSMC3IP, SMC2, TACC3, TIMELESS, TPX2, TTK, WEE1	395	cell cycle process
GO:0000278	3.118e-11	4.706	27 AURKB, BLM, BRCA2, BUB1, C18orf24, CCNA2, CDC7, CDCA8, CENPF, DDX11, DSN1, ERCC6L, HELLS, IL1B, KIF11, KIF15, KIF22, MAD2L1, NCAPD2, OIP5, POLA1, POLD1, SMC2, TIMELESS, TPX2, TTK, WEE1	315	mitotic cell cycle
GO:0000280	3.618e-11	2.6	21 AURKB, BUB1, C18orf24, CCNA2, CDCA8, CENPF, DDX11, DSN1, ERCC6L, HELLS, IL1B, KIF11, KIF15, KIF22, MAD2L1, NCAPD2, OIP5, SMC2, TIMELESS, TPX2, WEE1	174	nuclear division
GO:0007067	3.618e-11	2.6	21 AURKB, BUB1, C18orf24, CCNA2, CDCA8, CENPF, DDX11, DSN1, ERCC6L, HELLS, IL1B, KIF11, KIF15, KIF22, MAD2L1, NCAPD2, OIP5, SMC2, TIMELESS, TPX2, WEE1	174	mitosis
GO:0000087	5.009e-11	2.644	21 AURKB, BUB1, C18orf24, CCNA2, CDCA8, CENPF, DDX11, DSN1, ERCC6L, HELLS, IL1B, KIF11, KIF15, KIF22, MAD2L1, NCAPD2, OIP5, SMC2, TIMELESS, TPX2, WEE1	177	M phase of mitotic cell cycle
GO:0048285	6.890e-11	2.689	21 AURKB, BUB1, C18orf24, CCNA2, CDCA8, CENPF, DDX11, DSN1, ERCC6L, HELLS, IL1B, KIF11, KIF15, KIF22, MAD2L1, NCAPD2, OIP5, SMC2, TIMELESS, TPX2, WEE1	180	organelle fission
GO:0006259	9.176e-09	5.587	26 AREG, BLM, BRCA2, CDC7, CHAF1A, DTL, GINS1, GINS2, GINS3, HELLS, HMGB2, MCM10, MCM2, MCM5, MCM7, NEIL3, ORC6L, PARP2, POLA1, POLD1, POLD3, POLE2, PRIM1, PSMC3IP, RFC3, RNASEH2A	374	DNA metabolic process
GO:0051301	1.748e-08	2.883	19 AURKB, BLM, BRCA2, BUB1, C18orf24, CCNA2, CDC7, CDCA8, CENPF, DSN1, ERCC6L, HELLS, KIF11, MAD2L1, NCAPD2, OIP5, SMC2, TIMELESS, WEE1	193	cell division
GO:0008283	2.381e-06	8.441	28 AREG, BLM, BMP2, BRCA2, BUB1, CDC7, CENPF, DDX11, FABP3, FGF1, GINS1, HBEGF, HTR2A, IL1B, IL6, INSIG1, KIF15, LIF, MCM7, POLA1, PTHLH, SOX9, TACC3, TACSTD2, TGFBR1, TIMELESS, TPX2, TTK	565	cell proliferation
GO:0051320	1.082e-05	0.2241	6 BRCA2, CDC7, DDX11, POLA1, POLD1, TIMELESS	15	S phase
GO:0006261	5.121e-05	0.9113	9 HMGB2, MCM2, MCM5, MCM7, POLA1, POLD3, POLE2, PRIM1, RFC3	61	DNA-dependent DNA replication
GO:0006996	2.384e-04	13.39	32 ASF1B, AURKB, BLM, BRCA2, BUB1, C18orf24, CCNA2, CDCA8, CDYL, CENPF, CHAF1A, DDX11, DSN1, ERCC6L, EZH2, HELLS, HMGB2, IL1B, KIF11, KIF15, KIF22, KIF4A, MAD2L1, MCM2, NCAPD2, OIP5, SMC2, TACC3, TIMELESS, TPX2, TTK, WEE1	896	organelle organization
GO:0006974	2.800e-04	3.944	16 BARD1, BLM, BRCA2, CCNA2, CHAF1A, DTL, HMGB2, MCM7, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE2, RFC3, TIMELESS	264	response to DNA damage stimulus
GO:0000731	5.105e-04	0.1195	4 POLA1, POLD1, POLD3, RFC3	8	DNA synthesis during DNA repair
GO:0007093	6.734e-04	0.4482	6 BLM, BUB1, CCNA2, CENPF, MAD2L1, TTK	30	mitotic cell cycle checkpoint
GO:0001934	1.530e-03	0.5229	6 BMP2, IL1B, IL6, LIF, TGFBR1, TTK	35	positive regulation of protein amino acid phosphorylation
GO:0051325	1.729e-03	1.106	8 BLM, BRCA2, CDC7, CENPF, DDX11, POLA1, POLD1, TIMELESS	74	interphase
GO:0042325	2.404e-03	1.165	8 BARD1, BMP2, IL1B, IL6, LIF, MCM7, TGFBR1, TTK	78	regulation of phosphorylation
GO:0000084	2.655e-03	0.1793	4 BRCA2, DDX11, POLA1, POLD1	12	S phase of mitotic cell cycle
GO:0008284	2.773e-03	2.824	12 BLM, CDC7, DDX11, FGF1, HBEGF, HTR2A, IL1B, IL6, LIF, PTHLH, TGFBR1, TTK	189	positive regulation of cell proliferation
GO:0007094	3.711e-03	0.0747	3 BUB1, CENPF, TTK	5	mitotic cell cycle spindle assembly checkpoint
GO:0031577	3.711e-03	0.0747	3 BUB1, CENPF, TTK	5	spindle checkpoint
GO:0019220	3.799e-03	1.255	8 BARD1, BMP2, IL1B, IL6, LIF, MCM7, TGFBR1, TTK	84	regulation of phosphate metabolic process
GO:0051174	3.799e-03	1.255	8 BARD1, BMP2, IL1B, IL6, LIF, MCM7, TGFBR1, TTK	84	regulation of phosphorus metabolic process
GO:0042327	3.817e-03	0.6275	6 BMP2, IL1B, IL6, LIF, TGFBR1, TTK	42	positive regulation of phosphorylation
GO:0010562	4.787e-03	0.6573	6 BMP2, IL1B, IL6, LIF, TGFBR1, TTK	44	positive regulation of phosphorus metabolic process
GO:0045937	4.787e-03	0.6573	6 BMP2, IL1B, IL6, LIF, TGFBR1, TTK	44	positive regulation of phosphate metabolic process
GO:0042127	4.832e-03	5.692	17 BLM, BMP2, BRCA2, CDC7, DDX11, FABP3, FGF1, HBEGF, HTR2A, IL1B, IL6, LIF, PTHLH, SOX9, TGFBR1, TIMELESS, TTK	381	regulation of cell proliferation
GO:0007346	5.376e-03	1.33	8 BLM, BRCA2, BUB1, CCNA2, CENPF, IL1B, MAD2L1, TTK	89	regulation of mitotic cell cycle
GO:0006289	7.204e-03	0.7171	6 BRCA2, NEIL3, POLD1, POLD3, POLE2, RFC3	48	nucleotide-excision repair
GO:0031401	7.204e-03	0.7171	6 BMP2, IL1B, IL6, LIF, TGFBR1, TTK	48	positive regulation of protein modification process
GO:0051329	8.116e-03	1.061	7 BLM, BRCA2, CDC7, CENPF, DDX11, POLA1, POLD1	71	interphase of mitotic cell cycle
GO:0034645	8.889e-03	29.52	48 AREG, ASF1B, B3GNT2, BLM, BMP2, BMP6, BRCA2, CCNA2, CDC7, CDYL, CENPF, CHAF1A, DTL, E2F8, EZH2, FUT4, GINS1, GINS2, GINS3, HELLS, HMGB2, IL1B, IL6, ITGB3BP, LIF, MCM10, MCM2, MCM5, MCM7, MLF1IP, NR4A3, ORC6L, POLA1, POLD1, POLD3, POLE2, PRIM1, RELB, RFC3, RNASEH2A, SKIL, SOX9, SRF, ST3GAL1, TGFBR1, TIMELESS, TXNIP, ZNF672	1976	cellular macromolecule biosynthetic process
GO:0006297	9.154e-03	0.254	4 POLD1, POLD3, POLE2, RFC3	17	nucleotide-excision repair, DNA gap filling
GO:0009059	9.583e-03	29.63	48 AREG, ASF1B, B3GNT2, BLM, BMP2, BMP6, BRCA2, CCNA2, CDC7, CDYL, CENPF, CHAF1A, DTL, E2F8, EZH2, FUT4, GINS1, GINS2, GINS3, HELLS, HMGB2, IL1B, IL6, ITGB3BP, LIF, MCM10, MCM2, MCM5, MCM7, MLF1IP, NR4A3, ORC6L, POLA1, POLD1, POLD3, POLE2, PRIM1, RELB, RFC3, RNASEH2A, SKIL, SOX9, SRF, ST3GAL1, TGFBR1, TIMELESS, TXNIP, ZNF672	1983	macromolecule biosynthetic process
GO:0006950	1.013e-02	12.82	27 ANGPTL4, BARD1, BLM, BMP2, BMP6, BRCA2, CCNA2, CHAF1A, DTL, HBEGF, HMGB2, HTR2A, IL1B, IL6, MCM7, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE2, RFC3, SRF, TACC3, THBD, TIMELESS, TXNIP	858	response to stress
GO:0051726	1.163e-02	3.914	13 BLM, BMP2, BRCA2, BUB1, CCNA2, CDC7, CENPF, IL1B, MAD2L1, TACC3, TIMELESS, TP53BP2, TTK	262	regulation of cell cycle
GO:0009058	1.216e-02	35.35	54 AREG, ASF1B, B3GNT2, BLM, BMP2, BMP6, BRCA2, CCNA2, CDC7, CDYL, CENPF, CHAF1A, DTL, E2F8, EZH2, FABP3, FUT4, GFPT2, GINS1, GINS2, GINS3, HELLS, HMGB2, IDI2, IL1B, IL6, INSIG1, ITGB3BP, LIF, MCM10, MCM2, MCM5, MCM7, MLF1IP, NR4A3, ORC6L, POLA1, POLD1, POLD3, POLE2, PRIM1, PTHLH, RELB, RFC3, RNASEH2A, SC4MOL, SKIL, SOX9, SRF, ST3GAL1, TGFBR1, TIMELESS, TXNIP, ZNF672	2366	biosynthetic process
GO:0000075	1.317e-02	0.8217	6 BLM, BUB1, CCNA2, CENPF, MAD2L1, TTK	55	cell cycle checkpoint
GO:0001932	1.425e-02	0.8366	6 BMP2, IL1B, IL6, LIF, TGFBR1, TTK	56	regulation of protein amino acid phosphorylation
GO:0010862	1.428e-02	0.1195	3 BMP2, TGFBR1, TTK	8	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0044249	1.510e-02	34.78	53 AREG, ASF1B, B3GNT2, BLM, BMP2, BMP6, BRCA2, CCNA2, CDC7, CDYL, CENPF, CHAF1A, DTL, E2F8, EZH2, FABP3, FUT4, GINS1, GINS2, GINS3, HELLS, HMGB2, IDI2, IL1B, IL6, INSIG1, ITGB3BP, LIF, MCM10, MCM2, MCM5, MCM7, MLF1IP, NR4A3, ORC6L, POLA1, POLD1, POLD3, POLE2, PRIM1, PTHLH, RELB, RFC3, RNASEH2A, SC4MOL, SKIL, SOX9, SRF, ST3GAL1, TGFBR1, TIMELESS, TXNIP, ZNF672	2328	cellular biosynthetic process
GO:0034984	1.512e-02	3.511	12 BLM, BRCA2, CCNA2, CHAF1A, HMGB2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE2, RFC3	235	cellular response to DNA damage stimulus
GO:0006270	1.540e-02	0.2988	4 MCM2, MCM5, MCM7, POLA1	20	DNA replication initiation
GO:0034961	1.661e-02	27.82	45 AREG, ASF1B, BLM, BMP2, BMP6, BRCA2, CCNA2, CDC7, CDYL, CENPF, CHAF1A, DTL, E2F8, EZH2, GINS1, GINS2, GINS3, HELLS, HMGB2, IL1B, IL6, ITGB3BP, LIF, MCM10, MCM2, MCM5, MCM7, MLF1IP, NR4A3, ORC6L, POLA1, POLD1, POLD3, POLE2, PRIM1, RELB, RFC3, RNASEH2A, SKIL, SOX9, SRF, TGFBR1, TIMELESS, TXNIP, ZNF672	1862	cellular biopolymer biosynthetic process
GO:0043284	1.661e-02	27.82	45 AREG, ASF1B, BLM, BMP2, BMP6, BRCA2, CCNA2, CDC7, CDYL, CENPF, CHAF1A, DTL, E2F8, EZH2, GINS1, GINS2, GINS3, HELLS, HMGB2, IL1B, IL6, ITGB3BP, LIF, MCM10, MCM2, MCM5, MCM7, MLF1IP, NR4A3, ORC6L, POLA1, POLD1, POLD3, POLE2, PRIM1, RELB, RFC3, RNASEH2A, SKIL, SOX9, SRF, TGFBR1, TIMELESS, TXNIP, ZNF672	1862	biopolymer biosynthetic process
GO:0006281	1.701e-02	3.048	11 BLM, BRCA2, CHAF1A, HMGB2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE2, RFC3	204	DNA repair
GO:0006323	2.048e-02	0.9113	6 ASF1B, CHAF1A, HMGB2, MCM2, NCAPD2, SMC2	61	DNA packaging
GO:0051247	2.175e-02	1.3	7 BARD1, BMP2, IL1B, IL6, LIF, TGFBR1, TTK	87	positive regulation of protein metabolic process
GO:0048518	2.375e-02	12.97	26 ANGPTL4, AQP3, AREG, BARD1, BLM, BMP2, BMP6, BRCA2, CCNA2, CDC7, DDX11, FGF1, HBEGF, HTR2A, ICAM1, IL1B, IL6, LIF, NR4A3, PPP3CC, PTHLH, SOX9, SRF, TGFBR1, TP53BP2, TTK	868	positive regulation of biological process
GO:0033261	2.490e-02	0.1494	3 BRCA2, CDC7, TIMELESS	10	regulation of S phase
GO:0060393	2.490e-02	0.1494	3 BMP2, TGFBR1, TTK	10	regulation of pathway-restricted SMAD protein phosphorylation
GO:0050896	2.780e-02	20.17	35 ANGPTL4, AQP3, BARD1, BLM, BMP2, BMP6, BRCA2, CCNA2, CENPF, CHAF1A, DTL, GPR183, HBEGF, HMGB2, HTR2A, ICAM1, IL1B, IL6, LIF, MCM7, NEIL3, NR4A3, PARP2, POLA1, POLD1, POLD3, POLE2, RELB, RFC3, SRF, TACC3, TACSTD2, THBD, TIMELESS, TXNIP	1350	response to stimulus
GO:0006268	3.102e-02	0.1643	3 HMGB2, MCM2, MCM7	11	DNA unwinding during replication
GO:0010165	3.102e-02	0.1643	3 BLM, BRCA2, THBD	11	response to X-ray
GO:0051216	3.338e-02	0.3884	4 BMP2, BMP6, PTHLH, SOX9	26	cartilage development
GO:0007059	3.445e-02	0.6872	5 CENPF, DDX11, DSN1, NCAPD2, SMC2	46	chromosome segregation
GO:0006139	3.482e-02	34.41	51 AREG, ASF1B, BARD1, BLM, BMP2, BMP6, BRCA2, CCNA2, CDC7, CDYL, CENPF, CHAF1A, DDX11, DTL, E2F8, EZH2, GINS1, GINS2, GINS3, HELLS, HMGB2, IL1B, IL6, ITGB3BP, LIF, MCM10, MCM2, MCM5, MCM7, MLF1IP, NEIL3, NR4A3, ORC6L, PARP2, POLA1, POLD1, POLD3, POLE2, PRIM1, PSMC3IP, PTHLH, RELB, RFC3, RNASEH2A, SKIL, SOX9, SRF, TGFBR1, TIMELESS, TXNIP, ZNF672	2303	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0051240	3.693e-02	1.061	6 BMP2, BMP6, HTR2A, IL1B, IL6, SRF	71	positive regulation of multicellular organismal process
GO:0051051	3.699e-02	0.7022	5 BARD1, HTR2A, IL1B, LIF, TACC3	47	negative regulation of transport
GO:0001833	3.788e-02	0.04482	2 BRCA2, GINS1	3	inner cell mass cell proliferation
GO:0006271	3.788e-02	0.04482	2 POLA1, RFC3	3	DNA strand elongation during DNA replication
GO:0048478	3.788e-02	0.04482	2 BLM, BRCA2	3	replication fork protection
GO:0048522	3.848e-02	12.06	24 AREG, BARD1, BLM, BMP2, BMP6, BRCA2, CCNA2, CDC7, DDX11, FGF1, HBEGF, HTR2A, ICAM1, IL1B, IL6, LIF, NR4A3, PPP3CC, PTHLH, SOX9, SRF, TGFBR1, TP53BP2, TTK	807	positive regulation of cellular process
GO:0016043	4.019e-02	24.08	39 ASF1B, AURKB, BLM, BMP2, BRCA2, BUB1, C18orf24, CCNA2, CDCA8, CDYL, CENPF, CHAF1A, DDX11, DSN1, ERCC6L, EZH2, HELLS, HMGB2, IL1B, IL6, KIF11, KIF15, KIF22, KIF4A, MAD2L1, MCM2, NCAPD2, OIP5, SMC2, SOX9, SRF, SS18L1, TACC3, TGFBR1, TIMELESS, TPX2, TTK, VCL, WEE1	1612	cellular component organization
GO:0001649	4.091e-02	0.4183	4 BMP2, BMP6, IL6, PTHLH	28	osteoblast differentiation
GO:0051276	4.167e-02	4.093	12 ASF1B, BLM, BRCA2, CDYL, CENPF, CHAF1A, DDX11, EZH2, HMGB2, MCM2, NCAPD2, SMC2	274	chromosome organization
GO:0060389	4.416e-02	0.1942	3 BMP2, TGFBR1, TTK	13	pathway-restricted SMAD protein phosphorylation
GO:0010604	4.505e-02	5.363	14 AREG, BARD1, BLM, BMP2, BMP6, CCNA2, IL1B, IL6, LIF, NR4A3, SOX9, SRF, TGFBR1, TTK	359	positive regulation of macromolecule metabolic process
GO:0007017	4.601e-02	2.017	8 BRCA2, KIF11, KIF15, KIF18B, KIF22, KIF4A, TACC3, TTK	135	microtubule-based process

Id	Pvalue	ExpCount	Count	Size	Term
GO:0044427	7.849e-17	2.872	27 ASF1B, AURKB, BLM, BUB1, C18orf24, CDCA8, CDYL, CENPF, CENPI, CENPM, DSN1, ERCC6L, ITGB3BP, KIF22, MAD2L1, MCM2, MCM7, MLF1IP, NCAPD2, OIP5, ORC6L, POLA1, POLD3, PRIM1, RFC3, SMC2, TIMELESS	198	chromosomal part
GO:0005694	2.026e-15	3.597	28 ASF1B, AURKB, BLM, BUB1, C18orf24, CDCA8, CDYL, CENPF, CENPI, CENPM, DSN1, ERCC6L, HMGB2, ITGB3BP, KIF22, MAD2L1, MCM2, MCM7, MLF1IP, NCAPD2, OIP5, ORC6L, POLA1, POLD3, PRIM1, RFC3, SMC2, TIMELESS	248	chromosome
GO:0000775	2.647e-11	0.9138	14 AURKB, BUB1, C18orf24, CDCA8, CENPF, CENPI, CENPM, DSN1, ERCC6L, ITGB3BP, KIF22, MAD2L1, MLF1IP, OIP5	63	chromosome, centromeric region
GO:0000228	8.092e-08	1.117	12 BLM, BUB1, HMGB2, MCM2, MCM7, NCAPD2, ORC6L, POLA1, POLD3, PRIM1, SMC2, TIMELESS	77	nuclear chromosome
GO:0000793	1.894e-07	0.9574	11 BLM, BUB1, C18orf24, CENPF, CENPM, DSN1, ERCC6L, HMGB2, MLF1IP, NCAPD2, SMC2	66	condensed chromosome
GO:0000776	1.196e-06	0.6673	9 BUB1, C18orf24, CENPF, CENPM, DSN1, ERCC6L, KIF22, MAD2L1, MLF1IP	46	kinetochore
GO:0043228	2.905e-06	19.58	44 ANGPTL4, ASF1B, AURKB, BLM, BRCA2, BUB1, C18orf24, CDCA8, CDYL, CENPF, CENPI, CENPM, CKAP2, DDX11, DSN1, ERCC6L, HMGB2, ITGB3BP, KIF11, KIF15, KIF18B, KIF22, KIF4A, LMNB1, MAD2L1, MCM2, MCM7, MLF1IP, NCAPD2, NDEL1, OIP5, ORC6L, PARP2, POLA1, POLD3, PRIM1, RFC3, SMC2, SOX9, SRF, TIMELESS, TPX2, TTK, VCL	1350	non-membrane-bounded organelle
GO:0043232	2.905e-06	19.58	44 ANGPTL4, ASF1B, AURKB, BLM, BRCA2, BUB1, C18orf24, CDCA8, CDYL, CENPF, CENPI, CENPM, CKAP2, DDX11, DSN1, ERCC6L, HMGB2, ITGB3BP, KIF11, KIF15, KIF18B, KIF22, KIF4A, LMNB1, MAD2L1, MCM2, MCM7, MLF1IP, NCAPD2, NDEL1, OIP5, ORC6L, PARP2, POLA1, POLD3, PRIM1, RFC3, SMC2, SOX9, SRF, TIMELESS, TPX2, TTK, VCL	1350	intracellular non-membrane-bounded organelle
GO:0044454	7.392e-06	0.8268	9 BLM, BUB1, MCM2, MCM7, ORC6L, POLA1, POLD3, PRIM1, TIMELESS	57	nuclear chromosome part
GO:0005819	1.329e-05	1.16	10 AURKB, BUB1, C18orf24, CENPF, KIF11, KIF15, KIF4A, NDEL1, TPX2, TTK	80	spindle
GO:0000777	2.801e-05	0.4932	7 BUB1, C18orf24, CENPF, CENPM, DSN1, ERCC6L, MLF1IP	34	condensed chromosome kinetochore
GO:0000779	2.801e-05	0.4932	7 BUB1, C18orf24, CENPF, CENPM, DSN1, ERCC6L, MLF1IP	34	condensed chromosome, centromeric region
GO:0005657	8.514e-05	0.3771	6 BLM, MCM7, POLA1, POLD3, PRIM1, RFC3	26	replication fork
GO:0044428	3.093e-04	16.45	35 ANGPTL4, BARD1, BLM, BRCA2, BUB1, CCNA2, CDC7, CENPF, CHAF1A, DDX11, DTL, E2F8, EZH2, HMGB2, KIF4A, LMNB1, MCM10, MCM2, MCM5, MCM7, NCAPD2, OIP5, ORC6L, PARP2, POLA1, POLD1, POLD3, POLE2, PRIM1, RFC3, SMC2, SOX9, SRF, TIMELESS, WEE1	1134	nuclear part
GO:0044446	3.804e-04	39.09	62 ANGPTL4, ASF1B, AURKB, B3GNT2, BARD1, BLM, BRCA2, BUB1, C18orf24, CCNA2, CDC7, CDCA8, CDYL, CENPF, CENPI, CENPM, CHAF1A, CKAP2, DDX11, DSN1, DTL, E2F8, ENTPD7, ERCC6L, EZH2, GALNT4, HMGB2, INSIG1, ITGB3BP, KIF11, KIF15, KIF18B, KIF22, KIF4A, LMNB1, MAD2L1, MCM10, MCM2, MCM5, MCM7, MLF1IP, NCAPD2, NDEL1, OIP5, ORC6L, PARP2, POLA1, POLD1, POLD3, POLE2, PRIM1, RASGRP1, RFC3, SC4MOL, SMC2, SOX9, SRF, ST3GAL1, TIMELESS, TPX2, TTK, WEE1	2695	intracellular organelle part
GO:0044422	4.288e-04	39.24	62 ANGPTL4, ASF1B, AURKB, B3GNT2, BARD1, BLM, BRCA2, BUB1, C18orf24, CCNA2, CDC7, CDCA8, CDYL, CENPF, CENPI, CENPM, CHAF1A, CKAP2, DDX11, DSN1, DTL, E2F8, ENTPD7, ERCC6L, EZH2, GALNT4, HMGB2, INSIG1, ITGB3BP, KIF11, KIF15, KIF18B, KIF22, KIF4A, LMNB1, MAD2L1, MCM10, MCM2, MCM5, MCM7, MLF1IP, NCAPD2, NDEL1, OIP5, ORC6L, PARP2, POLA1, POLD1, POLD3, POLE2, PRIM1, RASGRP1, RFC3, SC4MOL, SMC2, SOX9, SRF, ST3GAL1, TIMELESS, TPX2, TTK, WEE1	2705	organelle part
GO:0031981	4.953e-04	12.55	29 ANGPTL4, BLM, BRCA2, CCNA2, CDC7, CENPF, CHAF1A, DDX11, E2F8, EZH2, HMGB2, KIF4A, LMNB1, MCM10, MCM2, MCM5, MCM7, OIP5, ORC6L, PARP2, POLA1, POLD1, POLD3, POLE2, PRIM1, RFC3, SOX9, SRF, WEE1	865	nuclear lumen
GO:0043596	5.873e-04	0.1596	4 MCM7, POLA1, POLD3, PRIM1	11	nuclear replication fork
GO:0000785	1.530e-03	1.276	8 ASF1B, CDYL, CENPF, MCM2, MCM7, OIP5, POLA1, TIMELESS	88	chromatin
GO:0005634	1.756e-03	44.84	66 ANGPTL4, ASF1B, AURKB, BARD1, BLM, BRCA2, BUB1, CCNA2, CCNJ, CDC7, CDCA8, CDYL, CENPF, CENPI, CENPM, CHAF1A, CPA3, DDX11, DEPDC1, DSN1, DTL, E2F8, EZH2, FBXW7, GINS1, GINS2, GINS3, HELLS, HJURP, HMGB2, ITGB3BP, KIF11, KIF22, KIF4A, LMNB1, MAD2L1, MCM10, MCM2, MCM5, MCM7, MLF1IP, NCAPD2, NEIL3, NR4A3, OIP5, ORC6L, PARP2, POLA1, POLD1, POLD3, POLE2, PRIM1, PSMC3IP, PTHLH, RELB, RFC3, RNASEH2A, SKIL, SMC2, SOX9, SRF, TIMELESS, TP53BP2, TPX2, WEE1, ZNF672	3091	nucleus
GO:0005654	2.248e-03	8.268	21 BLM, BRCA2, CCNA2, CDC7, CHAF1A, E2F8, EZH2, MCM10, MCM2, MCM5, MCM7, OIP5, ORC6L, PARP2, POLA1, POLD1, POLD3, POLE2, PRIM1, RFC3, WEE1	570	nucleoplasm
GO:0043234	4.278e-03	17.33	33 BARD1, BRCA2, BUB1, C18orf24, CDCA8, CENPF, CENPM, CHAF1A, DSN1, E2F8, ERCC6L, EZH2, IL6, KCNG1, KIF11, KIF15, KIF18B, KIF22, KIF4A, MAD2L1, MCM2, MCM7, MLF1IP, NCAPD2, ORC6L, PIK3CD, POLA1, POLD3, PRIM1, RFC3, SMC2, TGFBR1, VCL	1195	protein complex
GO:0000922	5.621e-03	0.2901	4 BUB1, CENPF, KIF11, TPX2	20	spindle pole
GO:0015630	6.945e-03	4.671	14 AURKB, BRCA2, BUB1, C18orf24, CENPF, CKAP2, KIF11, KIF15, KIF18B, KIF22, KIF4A, NDEL1, TPX2, TTK	322	microtubule cytoskeleton
GO:0005615	7.040e-03	3.568	12 ANGPTL4, AREG, BMP2, BMP6, FGF1, HBEGF, ICAM1, IL1B, IL6, LIF, PTHLH, THBD	246	extracellular space
GO:0030894	7.422e-03	0.1305	3 POLA1, POLD3, PRIM1	9	replisome
GO:0043601	7.422e-03	0.1305	3 POLA1, POLD3, PRIM1	9	nuclear replisome
GO:0034399	8.952e-03	0.5947	5 BLM, CENPF, KIF4A, LMNB1, POLA1	41	nuclear periphery
GO:0070013	1.237e-02	15.36	29 ANGPTL4, BLM, BRCA2, CCNA2, CDC7, CENPF, CHAF1A, DDX11, E2F8, EZH2, HMGB2, KIF4A, LMNB1, MCM10, MCM2, MCM5, MCM7, OIP5, ORC6L, PARP2, POLA1, POLD1, POLD3, POLE2, PRIM1, RFC3, SOX9, SRF, WEE1	1059	intracellular organelle lumen
GO:0043233	1.558e-02	15.61	29 ANGPTL4, BLM, BRCA2, CCNA2, CDC7, CENPF, CHAF1A, DDX11, E2F8, EZH2, HMGB2, KIF4A, LMNB1, MCM10, MCM2, MCM5, MCM7, OIP5, ORC6L, PARP2, POLA1, POLD1, POLD3, POLE2, PRIM1, RFC3, SOX9, SRF, WEE1	1076	organelle lumen
GO:0031974	2.148e-02	15.97	29 ANGPTL4, BLM, BRCA2, CCNA2, CDC7, CENPF, CHAF1A, DDX11, E2F8, EZH2, HMGB2, KIF4A, LMNB1, MCM10, MCM2, MCM5, MCM7, OIP5, ORC6L, PARP2, POLA1, POLD1, POLD3, POLE2, PRIM1, RFC3, SOX9, SRF, WEE1	1101	membrane-enclosed lumen
GO:0044430	2.635e-02	6.092	15 AURKB, BRCA2, BUB1, C18orf24, CENPF, CKAP2, KIF11, KIF15, KIF18B, KIF22, KIF4A, LMNB1, NDEL1, TPX2, TTK	420	cytoskeletal part
GO:0005664	3.040e-02	0.05802	2 MCM2, ORC6L	4	nuclear origin of replication recognition complex
GO:0000808	4.527e-02	0.07253	2 MCM2, ORC6L	5	origin recognition complex
GO:0005658	4.527e-02	0.07253	2 POLA1, PRIM1	5	alpha DNA polymerase:primase complex
GO:0016363	4.702e-02	0.5512	4 BLM, CENPF, KIF4A, POLA1	38	nuclear matrix

Id	Pvalue	ExpCount	Count	Size	Term
GO:0008083	7.007e-03	1.325	8 AREG, BMP2, BMP6, FGF1, HBEGF, IL1B, IL6, LIF	94	growth factor activity
GO:0003887	1.193e-02	0.2538	4 POLA1, POLD1, POLD3, POLE2	18	DNA-directed DNA polymerase activity
GO:0003777	1.667e-02	0.5216	5 KIF11, KIF15, KIF18B, KIF22, KIF4A	37	microtubule motor activity
GO:0034061	1.914e-02	0.296	4 POLA1, POLD1, POLD3, POLE2	21	DNA polymerase activity
GO:0005125	4.071e-02	1.029	6 AREG, BMP2, BMP6, IL1B, IL6, LIF	73	cytokine activity
GO:0003896	4.291e-02	0.04229	2 POLA1, PRIM1	3	DNA primase activity

Id	Pvalue	ExpCount	Count	Size	Term
03030	8.825e-08	0.6537	10 MCM2, MCM5, MCM7, POLA1, POLD1, POLD3, POLE2, PRIM1, RFC3, RNASEH2A	33	DNA replication
04110	9.112e-03	1.941	9 BUB1, CCNA2, CDC7, MAD2L1, MCM2, MCM5, MCM7, ORC6L, WEE1	98	Cell cycle
03410	1.909e-02	0.5943	5 NEIL3, PARP2, POLD1, POLD3, POLE2	30	Base excision repair

No enriched terms

No enriched terms

Entrez genes

ANGPTL4angiopoietin-like 4 (221009_s_at), score: -0.84 AQP3aquaporin 3 (Gill blood group) (39248_at), score: -0.82 AREGamphiregulin (205239_at), score: -0.88 ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae) (218115_at), score: 0.71 AURKBaurora kinase B (209464_at), score: 0.72 B3GNT2UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (219326_s_at), score: -0.87 BARD1BRCA1 associated RING domain 1 (205345_at), score: 0.67 BLMBloom syndrome (205733_at), score: 0.68 BMP2bone morphogenetic protein 2 (205289_at), score: -0.91 BMP6bone morphogenetic protein 6 (206176_at), score: -0.87 BRCA2breast cancer 2, early onset (208368_s_at), score: 0.67 BUB1budding uninhibited by benzimidazoles 1 homolog (yeast) (209642_at), score: 0.69 C17orf91chromosome 17 open reading frame 91 (214696_at), score: -0.9 C18orf24chromosome 18 open reading frame 24 (217640_x_at), score: 0.71 CBR3carbonyl reductase 3 (205379_at), score: 0.74 CCNA2cyclin A2 (203418_at), score: 0.68 CCNJcyclin J (219470_x_at), score: -0.82 CDC7cell division cycle 7 homolog (S. cerevisiae) (204510_at), score: 0.74 CDCA8cell division cycle associated 8 (221520_s_at), score: 0.68 CDYLchromodomain protein, Y-like (203100_s_at), score: -0.77 CENPFcentromere protein F, 350/400ka (mitosin) (207828_s_at), score: 0.7 CENPIcentromere protein I (214804_at), score: 0.68 CENPMcentromere protein M (218741_at), score: 0.73 CHAF1Achromatin assembly factor 1, subunit A (p150) (214426_x_at), score: 0.68 CKAP2cytoskeleton associated protein 2 (218252_at), score: 0.72 CPA3carboxypeptidase A3 (mast cell) (205624_at), score: -0.8 CXCR7chemokine (C-X-C motif) receptor 7 (212977_at), score: -0.84 DDX11DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) (208149_x_at), score: 0.69 DEPDC1DEP domain containing 1 (220295_x_at), score: 0.7 DSN1DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) (219512_at), score: 0.74 DTLdenticleless homolog (Drosophila) (218585_s_at), score: 0.68 E2F8E2F transcription factor 8 (219990_at), score: 0.7 ENTPD7ectonucleoside triphosphate diphosphohydrolase 7 (220153_at), score: -1 ERCC6Lexcision repair cross-complementing rodent repair deficiency, complementation group 6-like (219650_at), score: 0.68 EZH2enhancer of zeste homolog 2 (Drosophila) (203358_s_at), score: 0.73 FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (214285_at), score: -0.78 FAM64Afamily with sequence similarity 64, member A (221591_s_at), score: 0.67 FBXW7F-box and WD repeat domain containing 7 (218751_s_at), score: -0.75 FGF1fibroblast growth factor 1 (acidic) (205117_at), score: -0.73 FUT4fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) (209892_at), score: -0.74 GALNT4UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4) (220442_at), score: -0.77 GFPT2glutamine-fructose-6-phosphate transaminase 2 (205100_at), score: -0.85 GINS1GINS complex subunit 1 (Psf1 homolog) (206102_at), score: 0.69 GINS2GINS complex subunit 2 (Psf2 homolog) (221521_s_at), score: 0.71 GINS3GINS complex subunit 3 (Psf3 homolog) (45633_at), score: 0.68 GPR183G protein-coupled receptor 183 (205419_at), score: -0.97 HBEGFheparin-binding EGF-like growth factor (203821_at), score: -0.73 HELLShelicase, lymphoid-specific (220085_at), score: 0.67 HJURPHolliday junction recognition protein (218726_at), score: 0.68 HMGB2high-mobility group box 2 (208808_s_at), score: 0.73 HMMRhyaluronan-mediated motility receptor (RHAMM) (207165_at), score: 0.67 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (207135_at), score: -0.74 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: -0.87 IDI2isopentenyl-diphosphate delta isomerase 2 (217631_at), score: -0.76 IL1Binterleukin 1, beta (39402_at), score: -0.85 IL6interleukin 6 (interferon, beta 2) (205207_at), score: -0.79 INSIG1insulin induced gene 1 (201627_s_at), score: -0.79 ITGB3BPintegrin beta 3 binding protein (beta3-endonexin) (205176_s_at), score: 0.69 JHDM1Djumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (221778_at), score: -0.85 KCNG1potassium voltage-gated channel, subfamily G, member 1 (214595_at), score: -0.81 KIF11kinesin family member 11 (204444_at), score: 0.67 KIF15kinesin family member 15 (219306_at), score: 0.69 KIF18Bkinesin family member 18B (222039_at), score: 0.75 KIF22kinesin family member 22 (202183_s_at), score: 0.67 KIF4Akinesin family member 4A (218355_at), score: 0.71 LAMC2laminin, gamma 2 (202267_at), score: -0.8 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: -0.78 LMNB1lamin B1 (203276_at), score: 0.67 MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast) (203362_s_at), score: 0.68 MCM10minichromosome maintenance complex component 10 (220651_s_at), score: 0.72 MCM2minichromosome maintenance complex component 2 (202107_s_at), score: 0.69 MCM5minichromosome maintenance complex component 5 (216237_s_at), score: 0.7 MCM7minichromosome maintenance complex component 7 (210983_s_at), score: 0.68 MLF1IPMLF1 interacting protein (218883_s_at), score: 0.67 NCAPD2non-SMC condensin I complex, subunit D2 (201774_s_at), score: 0.67 NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 1 (208093_s_at), score: -0.73 NEIL3nei endonuclease VIII-like 3 (E. coli) (219502_at), score: 0.69 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: -0.73 OIP5Opa interacting protein 5 (213599_at), score: 0.7 ORC6Lorigin recognition complex, subunit 6 like (yeast) (219105_x_at), score: 0.69 PARP2poly (ADP-ribose) polymerase 2 (214086_s_at), score: 0.68 PIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide (203879_at), score: -0.82 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: -0.85 POLA1polymerase (DNA directed), alpha 1, catalytic subunit (204835_at), score: 0.74 POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa (203422_at), score: 0.7 POLD3polymerase (DNA-directed), delta 3, accessory subunit (212836_at), score: 0.7 POLE2polymerase (DNA directed), epsilon 2 (p59 subunit) (205909_at), score: 0.69 PPP3CCprotein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (207000_s_at), score: -0.81 PRIM1primase, DNA, polypeptide 1 (49kDa) (205053_at), score: 0.76 PSMC3IPPSMC3 interacting protein (213951_s_at), score: 0.69 PTHLHparathyroid hormone-like hormone (211756_at), score: -0.94 RASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated) (205590_at), score: -0.89 RASSF8Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 (207754_at), score: -0.75 RELBv-rel reticuloendotheliosis viral oncogene homolog B (205205_at), score: -0.74 RFC3replication factor C (activator 1) 3, 38kDa (204127_at), score: 0.7 RNASEH2Aribonuclease H2, subunit A (203022_at), score: 0.69 SC4MOLsterol-C4-methyl oxidase-like (209146_at), score: -0.78 SKILSKI-like oncogene (206675_s_at), score: -0.8 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: -0.84 SMC2structural maintenance of chromosomes 2 (204240_s_at), score: 0.68 SOX9SRY (sex determining region Y)-box 9 (202935_s_at), score: -0.78 SPATA2Lspermatogenesis associated 2-like (214965_at), score: -0.81 SRFserum response factor (c-fos serum response element-binding transcription factor) (202401_s_at), score: -0.75 SS18L1synovial sarcoma translocation gene on chromosome 18-like 1 (213140_s_at), score: -0.74 ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (208322_s_at), score: -0.8 STK38Lserine/threonine kinase 38 like (212572_at), score: -0.9 TACC3transforming, acidic coiled-coil containing protein 3 (218308_at), score: 0.67 TACSTD2tumor-associated calcium signal transducer 2 (202286_s_at), score: -0.89 TGFBR1transforming growth factor, beta receptor 1 (206943_at), score: -0.81 THBDthrombomodulin (203887_s_at), score: -0.78 TIMELESStimeless homolog (Drosophila) (203046_s_at), score: 0.69 TMEM194Atransmembrane protein 194A (212621_at), score: 0.77 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: -0.74 TPX2TPX2, microtubule-associated, homolog (Xenopus laevis) (210052_s_at), score: 0.68 TRPC6transient receptor potential cation channel, subfamily C, member 6 (217287_s_at), score: -0.85 TTC17tetratricopeptide repeat domain 17 (218972_at), score: -0.81 TTKTTK protein kinase (204822_at), score: 0.74 TXNIPthioredoxin interacting protein (201008_s_at), score: 0.72 VCLvinculin (200930_s_at), score: -0.85 WEE1WEE1 homolog (S. pombe) (212533_at), score: 0.72 YRDCyrdC domain containing (E. coli) (218647_s_at), score: -0.85 ZNF672zinc finger protein 672 (218068_s_at), score: -0.73

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
E-TABM-263-raw-cel-1515485851.cel	11	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486231.cel	30	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486351.cel	36	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486331.cel	35	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515485811.cel	9	6	Cycle	hgu133a2	none	Cycle 1