Previous module | Next module Module #637, TG: 2.8, TC: 1.8, 132 probes, 132 Entrez genes, 6 conditions

Help | Hide | Top Help | Show | Top Expression data

DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

chromosome segregation

The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.

cell cycle checkpoint

The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.

DNA replication checkpoint

A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

mitotic cell cycle

Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.

M phase

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.

nuclear division

A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.

cellular alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

DNA-dependent DNA replication

The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

DNA replication initiation

The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

DNA packaging

Any process by which DNA and associated proteins are formed into a compact, orderly structure.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

cholesterol biosynthetic process

The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

response to DNA damage stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

organelle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

microtubule-based process

Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.

microtubule-based movement

Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

spindle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

mitotic cell cycle spindle assembly checkpoint

A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly).

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

negative regulation of biosynthetic process

Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of macromolecule biosynthetic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cell cycle process

Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cellular component organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cellular component.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

regulation of DNA replication initiation

Any process that modulates the frequency, rate or extent of initiation of DNA replication; the process by which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.

cytoskeleton-dependent intracellular transport

The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

negative regulation of cellular biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

DNA integrity checkpoint

Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure.

spindle checkpoint

A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle.

negative regulation of DNA replication initiation

Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular response to DNA damage stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

intracellular transport

The directed movement of substances within a cell.

organelle fission

The creation of two or more organelles by division of one organelle.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of DNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cell division

The process resulting in the physical partitioning and separation of a cell into daughter cells.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

interphase

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

interphase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

all

This term is the most general term possible

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biosynthetic process

Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.

regulation of biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

intracellular transport

The directed movement of substances within a cell.

negative regulation of biosynthetic process

Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of macromolecule biosynthetic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

negative regulation of cellular biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

negative regulation of macromolecule biosynthetic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of cellular biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

regulation of cell cycle process

Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cellular response to DNA damage stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

negative regulation of macromolecule biosynthetic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

negative regulation of cellular biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

regulation of DNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

regulation of DNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

spindle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

interphase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

microtubule-based movement

Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

cholesterol biosynthetic process

The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

regulation of DNA replication initiation

Any process that modulates the frequency, rate or extent of initiation of DNA replication; the process by which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.

negative regulation of DNA replication initiation

Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication.

mitotic cell cycle spindle assembly checkpoint

A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly).

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

negative regulation of DNA replication initiation

Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication.

DNA replication checkpoint

A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.

DNA replication initiation

The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

condensed chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosome, centromeric region

The region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

chromosome

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

microtubule associated complex

Any multimeric complex connected to a microtubule.

spindle microtubule

Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

membrane-enclosed lumen

The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

all

This term is the most general term possible

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule associated complex

Any multimeric complex connected to a microtubule.

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

spindle microtubule

Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

microtubule associated complex

Any multimeric complex connected to a microtubule.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

nucleotide binding

Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

motor activity

Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate.

microtubule motor activity

Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

nucleoside-triphosphatase activity

Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

ATP binding

Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

pyrophosphatase activity

Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

hydrolase activity, acting on acid anhydrides

Catalysis of the hydrolysis of any acid anhydride.

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.

purine nucleotide binding

Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate.

adenyl nucleotide binding

Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.

ribonucleotide binding

Interacting selectively with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

purine ribonucleotide binding

Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

adenyl ribonucleotide binding

Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

all

This term is the most general term possible

purine ribonucleotide binding

Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

adenyl ribonucleotide binding

Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022403	6.458e-27	4.642	42 AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CDC6, CDC7, CDCA8, CDK2, CDT1, CENPE, CENPF, CIT, DSN1, ERCC6L, EXO1, GTSE1, HELLS, IL1B, KIF11, KIF15, KIF20B, KIF2C, KNTC1, MAD2L1, NCAPG, NCAPH, OIP5, PKMYT1, POLA1, POLD1, PSMC3IP, RAD54B, SMC2, SPAG5, SPC25, TACC3, TIMELESS, TPX2, TTK	287	cell cycle phase
GO:0000279	1.157e-24	3.736	37 AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CDC6, CDCA8, CDK2, CENPE, CENPF, CIT, DSN1, ERCC6L, EXO1, HELLS, IL1B, KIF11, KIF15, KIF20B, KIF2C, KNTC1, MAD2L1, NCAPG, NCAPH, OIP5, PKMYT1, PSMC3IP, RAD54B, SMC2, SPAG5, SPC25, TACC3, TIMELESS, TPX2, TTK	231	M phase
GO:0000280	8.111e-23	2.814	32 AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CDC6, CDCA8, CDK2, CENPE, CENPF, CIT, DSN1, ERCC6L, HELLS, IL1B, KIF11, KIF15, KIF20B, KIF2C, KNTC1, MAD2L1, NCAPG, NCAPH, OIP5, PKMYT1, SMC2, SPAG5, SPC25, TIMELESS, TPX2	174	nuclear division
GO:0007067	8.111e-23	2.814	32 AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CDC6, CDCA8, CDK2, CENPE, CENPF, CIT, DSN1, ERCC6L, HELLS, IL1B, KIF11, KIF15, KIF20B, KIF2C, KNTC1, MAD2L1, NCAPG, NCAPH, OIP5, PKMYT1, SMC2, SPAG5, SPC25, TIMELESS, TPX2	174	mitosis
GO:0000087	1.421e-22	2.863	32 AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CDC6, CDCA8, CDK2, CENPE, CENPF, CIT, DSN1, ERCC6L, HELLS, IL1B, KIF11, KIF15, KIF20B, KIF2C, KNTC1, MAD2L1, NCAPG, NCAPH, OIP5, PKMYT1, SMC2, SPAG5, SPC25, TIMELESS, TPX2	177	M phase of mitotic cell cycle
GO:0007049	1.756e-22	10.54	53 AURKB, BARD1, BIRC5, BRIP1, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDT1, CENPE, CENPF, CHAF1A, CHAF1B, CIT, CKAP2, DSN1, ERCC6L, EXO1, FANCG, GTSE1, HELLS, IL1B, KIF11, KIF15, KIF20B, KIF2C, KNTC1, MAD2L1, MCM2, MKI67, NCAPG, NCAPH, OIP5, PKMYT1, POLA1, POLD1, PSMC3IP, RAD54B, RBL1, SMC2, SPAG5, SPC25, TACC3, TIMELESS, TPX2, TTK	652	cell cycle
GO:0048285	2.452e-22	2.911	32 AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CDC6, CDCA8, CDK2, CENPE, CENPF, CIT, DSN1, ERCC6L, HELLS, IL1B, KIF11, KIF15, KIF20B, KIF2C, KNTC1, MAD2L1, NCAPG, NCAPH, OIP5, PKMYT1, SMC2, SPAG5, SPC25, TIMELESS, TPX2	180	organelle fission
GO:0022402	2.724e-22	6.388	43 AURKB, BARD1, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CDC6, CDC7, CDCA8, CDK2, CDT1, CENPE, CENPF, CIT, DSN1, ERCC6L, EXO1, GTSE1, HELLS, IL1B, KIF11, KIF15, KIF20B, KIF2C, KNTC1, MAD2L1, NCAPG, NCAPH, OIP5, PKMYT1, POLA1, POLD1, PSMC3IP, RAD54B, SMC2, SPAG5, SPC25, TACC3, TIMELESS, TPX2, TTK	395	cell cycle process
GO:0000278	7.846e-21	5.095	38 AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CDC6, CDC7, CDCA8, CDK2, CDT1, CENPE, CENPF, CIT, DSN1, ERCC6L, GTSE1, HELLS, IL1B, KIF11, KIF15, KIF20B, KIF2C, KNTC1, MAD2L1, NCAPG, NCAPH, OIP5, PKMYT1, POLA1, POLD1, SMC2, SPAG5, SPC25, TIMELESS, TPX2, TTK	315	mitotic cell cycle
GO:0051301	1.009e-16	3.121	28 AURKB, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNE2, CDC6, CDC7, CDCA8, CDK2, CENPE, CENPF, CIT, DSN1, ERCC6L, HELLS, KIF11, KIF20B, KNTC1, MAD2L1, NCAPG, NCAPH, OIP5, SMC2, SPAG5, SPC25, TIMELESS	193	cell division
GO:0006260	3.608e-14	2.927	25 CDC45L, CDC6, CDC7, CDK2, CDT1, CHAF1A, CHAF1B, DTL, EXO1, GINS1, GINS2, GINS3, MCM10, MCM2, MCM4, MCM5, ORC1L, ORC6L, POLA1, POLD1, POLE2, POLQ, PRIM1, RFC3, RNASEH2A	181	DNA replication
GO:0006259	8.358e-12	6.049	31 BRIP1, CDC45L, CDC6, CDC7, CDK2, CDT1, CHAF1A, CHAF1B, DTL, EXO1, FANCG, GINS1, GINS2, GINS3, HELLS, MCM10, MCM2, MCM4, MCM5, NEIL3, ORC1L, ORC6L, POLA1, POLD1, POLE2, POLQ, PRIM1, PSMC3IP, RAD54B, RFC3, RNASEH2A	374	DNA metabolic process
GO:0000075	5.364e-11	0.8895	14 BRIP1, BUB1, BUB1B, CCNA2, CCNE2, CDC45L, CDC6, CDT1, CENPF, FANCG, GTSE1, KNTC1, MAD2L1, TTK	55	cell cycle checkpoint
GO:0006996	9.923e-10	14.49	44 ASF1B, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CDC6, CDCA8, CDK2, CENPE, CENPF, CHAF1A, CHAF1B, CIT, DSN1, ERCC6L, EXOSC9, EZH2, FANCG, HELLS, IL1B, KIF11, KIF15, KIF20B, KIF2C, KIF4A, KNTC1, MAD2L1, MCM2, NCAPG, NCAPH, OIP5, PKMYT1, PRKG1, RBL1, SMC2, SPAG5, SPC25, TACC3, TIMELESS, TPX2, TTK	896	organelle organization
GO:0007346	3.997e-08	1.439	14 BUB1, BUB1B, CCNA2, CDC6, CDK2, CDT1, CENPF, GTSE1, IL1B, KIF20B, KNTC1, MAD2L1, PKMYT1, TTK	89	regulation of mitotic cell cycle
GO:0051726	4.884e-08	4.237	22 BRIP1, BUB1, BUB1B, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, FANCG, GTSE1, IL1B, KIF20B, KNTC1, MAD2L1, PKMYT1, RBL1, TACC3, TIMELESS, TTK	262	regulation of cell cycle
GO:0006261	5.980e-08	0.9866	12 CDC45L, CDC6, CDT1, EXO1, MCM2, MCM4, MCM5, ORC1L, POLA1, POLE2, PRIM1, RFC3	61	DNA-dependent DNA replication
GO:0006270	1.381e-07	0.3235	8 CDC45L, CDC6, CDT1, MCM2, MCM4, MCM5, ORC1L, POLA1	20	DNA replication initiation
GO:0007093	4.324e-06	0.4852	8 BUB1, BUB1B, CCNA2, CENPF, GTSE1, KNTC1, MAD2L1, TTK	30	mitotic cell cycle checkpoint
GO:0007017	7.360e-06	2.183	14 BUB1B, CENPE, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, SPAG5, TACC3, TTK	135	microtubule-based process
GO:0007018	9.546e-05	0.9866	9 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A	61	microtubule-based movement
GO:0016125	1.576e-04	1.051	9 DHCR7, IDI1, INSIG1, LSS, MVD, SC4MOL, SQLE, SREBF2, TM7SF2	65	sterol metabolic process
GO:0016126	1.700e-04	0.5499	7 DHCR7, IDI1, LSS, MVD, SC4MOL, SQLE, TM7SF2	34	sterol biosynthetic process
GO:0006974	1.819e-04	4.27	17 BARD1, BRIP1, CCNA2, CHAF1A, CHAF1B, DTL, EXO1, FANCG, GTSE1, NEIL3, POLA1, POLD1, POLE2, POLQ, RAD54B, RFC3, TIMELESS	264	response to DNA damage stimulus
GO:0030705	3.105e-04	1.148	9 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A	71	cytoskeleton-dependent intracellular transport
GO:0051325	4.235e-04	1.197	9 CDC6, CDC7, CDK2, CDT1, CENPF, GTSE1, POLA1, POLD1, TIMELESS	74	interphase
GO:0051320	4.426e-04	0.2426	5 CDC7, CDT1, POLA1, POLD1, TIMELESS	15	S phase
GO:0016043	5.887e-04	26.07	48 ASF1B, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CDC6, CDCA8, CDK2, CENPE, CENPF, CHAF1A, CHAF1B, CIT, COL14A1, DSN1, ERCC6L, EXOSC9, EZH2, FANCG, HELLS, IL1B, IL6, KIF11, KIF15, KIF20B, KIF2C, KIF4A, KNTC1, MAD2L1, MCM2, NCAPG, NCAPH, OIP5, PKMYT1, PRKG1, QPRT, RBL1, SMC2, SPAG5, SPC25, TACC3, TGFBR1, TIMELESS, TPX2, TTK	1612	cellular component organization
GO:0031570	6.932e-04	0.4529	6 BRIP1, CCNA2, CDC45L, CDC6, CDT1, GTSE1	28	DNA integrity checkpoint
GO:0008283	1.283e-03	9.138	24 BUB1, BUB1B, CDC6, CDC7, CDK2, CENPF, DHCR7, FABP3, GINS1, IL1B, IL6, INSIG1, KIF15, KIF2C, MKI67, PDGFRB, POLA1, STIL, TACC3, TACSTD2, TGFBR1, TIMELESS, TPX2, TTK	565	cell proliferation
GO:0051329	2.184e-03	1.148	8 CDC6, CDC7, CDK2, CDT1, CENPF, GTSE1, POLA1, POLD1	71	interphase of mitotic cell cycle
GO:0010564	2.285e-03	0.841	7 CDC7, CDT1, IL1B, KIF20B, KNTC1, PKMYT1, TIMELESS	52	regulation of cell cycle process
GO:0034984	2.859e-03	3.801	14 BRIP1, CCNA2, CHAF1A, CHAF1B, EXO1, FANCG, GTSE1, NEIL3, POLA1, POLD1, POLE2, POLQ, RAD54B, RFC3	235	cellular response to DNA damage stimulus
GO:0006694	3.459e-03	0.9057	7 DHCR7, IDI1, LSS, MVD, SC4MOL, SQLE, TM7SF2	56	steroid biosynthetic process
GO:0008203	3.816e-03	0.9219	7 DHCR7, IDI1, INSIG1, LSS, MVD, SREBF2, TM7SF2	57	cholesterol metabolic process
GO:0007094	4.528e-03	0.08087	3 BUB1, CENPF, TTK	5	mitotic cell cycle spindle assembly checkpoint
GO:0031577	4.528e-03	0.08087	3 BUB1, CENPF, TTK	5	spindle checkpoint
GO:0006695	4.664e-03	0.4043	5 DHCR7, IDI1, LSS, MVD, TM7SF2	25	cholesterol biosynthetic process
GO:0007051	4.664e-03	0.4043	5 BUB1B, KIF11, SPAG5, TACC3, TTK	25	spindle organization
GO:0006323	5.522e-03	0.9866	7 ASF1B, CHAF1A, CHAF1B, MCM2, NCAPG, NCAPH, SMC2	61	DNA packaging
GO:0033554	6.226e-03	5.24	16 BRIP1, CCNA2, CHAF1A, CHAF1B, EXO1, FADS1, FANCG, GTSE1, IL1B, NEIL3, POLA1, POLD1, POLE2, POLQ, RAD54B, RFC3	324	cellular response to stress
GO:0000076	7.858e-03	0.09704	3 CDC45L, CDC6, CDT1	6	DNA replication checkpoint
GO:0032297	7.858e-03	0.09704	3 CDC45L, CDC6, CDT1	6	negative regulation of DNA replication initiation
GO:0008202	7.997e-03	1.828	9 DHCR7, IDI1, INSIG1, LSS, MVD, SC4MOL, SQLE, SREBF2, TM7SF2	113	steroid metabolic process
GO:0007059	8.451e-03	0.744	6 CENPE, CENPF, DSN1, NCAPG, NCAPH, SMC2	46	chromosome segregation
GO:0006281	9.727e-03	3.299	12 BRIP1, CHAF1A, CHAF1B, EXO1, FANCG, NEIL3, POLA1, POLD1, POLE2, POLQ, RAD54B, RFC3	204	DNA repair
GO:0051716	1.007e-02	5.515	16 BRIP1, CCNA2, CHAF1A, CHAF1B, EXO1, FADS1, FANCG, GTSE1, IL1B, NEIL3, POLA1, POLD1, POLE2, POLQ, RAD54B, RFC3	341	cellular response to stimulus
GO:0030174	1.205e-02	0.1132	3 CDC45L, CDC6, CDT1	7	regulation of DNA replication initiation
GO:0000731	1.702e-02	0.1294	3 POLA1, POLD1, RFC3	8	DNA synthesis during DNA repair
GO:0006335	1.954e-02	0.03235	2 CHAF1A, CHAF1B	2	DNA replication-dependent nucleosome assembly
GO:0034723	1.954e-02	0.03235	2 CHAF1A, CHAF1B	2	DNA replication-dependent nucleosome organization
GO:0000070	2.941e-02	0.372	4 CENPE, NCAPG, NCAPH, SMC2	23	mitotic sister chromatid segregation
GO:0033261	2.950e-02	0.1617	3 CDC7, CDT1, TIMELESS	10	regulation of S phase
GO:0000819	3.307e-02	0.3882	4 CENPE, NCAPG, NCAPH, SMC2	24	sister chromatid segregation
GO:0006271	4.236e-02	0.04852	2 POLA1, RFC3	3	DNA strand elongation during DNA replication
GO:0034508	4.236e-02	0.04852	2 CENPE, CENPF	3	centromere complex assembly
GO:0051310	4.236e-02	0.04852	2 CENPE, CENPF	3	metaphase plate congression
GO:0051382	4.236e-02	0.04852	2 CENPE, CENPF	3	kinetochore assembly
GO:0051383	4.236e-02	0.04852	2 CENPE, CENPF	3	kinetochore organization
GO:0000084	4.380e-02	0.1941	3 CDT1, POLA1, POLD1	12	S phase of mitotic cell cycle
GO:0007076	4.380e-02	0.1941	3 NCAPG, NCAPH, SMC2	12	mitotic chromosome condensation
GO:0008610	4.851e-02	3.073	10 DHCR7, FABP3, FADS1, IDI1, LSS, MVD, SC4MOL, SCD, SQLE, TM7SF2	190	lipid biosynthetic process

Id	Pvalue	ExpCount	Count	Size	Term
GO:0044427	4.268e-18	3.097	29 ASF1B, AURKB, BUB1, BUB1B, C18orf24, C21orf45, CDCA8, CDT1, CENPE, CENPF, CENPI, CENPM, DSN1, ERCC6L, KIF2C, KNTC1, MAD2L1, MCM2, NCAPG, NCAPH, OIP5, ORC6L, POLA1, PRIM1, RFC3, SMC2, SPAG5, SPC25, TIMELESS	198	chromosomal part
GO:0005694	1.848e-16	3.879	30 ASF1B, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CDCA8, CDT1, CENPE, CENPF, CENPI, CENPM, DSN1, ERCC6L, KIF2C, KNTC1, MAD2L1, MCM2, NCAPG, NCAPH, OIP5, ORC6L, POLA1, PRIM1, RFC3, SMC2, SPAG5, SPC25, TIMELESS	248	chromosome
GO:0000775	4.468e-16	0.9854	18 AURKB, BUB1, BUB1B, C18orf24, C21orf45, CDCA8, CENPE, CENPF, CENPI, CENPM, DSN1, ERCC6L, KIF2C, KNTC1, MAD2L1, OIP5, SPAG5, SPC25	63	chromosome, centromeric region
GO:0000793	1.404e-10	1.032	14 BUB1, BUB1B, C18orf24, CENPE, CENPF, CENPM, DSN1, ERCC6L, KNTC1, NCAPG, NCAPH, SMC2, SPAG5, SPC25	66	condensed chromosome
GO:0005819	1.414e-10	1.251	15 AURKB, BUB1, BUB1B, C18orf24, CDC6, CENPE, CENPF, KIF11, KIF14, KIF15, KIF4A, KNTC1, SPAG5, TPX2, TTK	80	spindle
GO:0000777	2.544e-10	0.5318	11 BUB1, BUB1B, C18orf24, CENPE, CENPF, CENPM, DSN1, ERCC6L, KNTC1, SPAG5, SPC25	34	condensed chromosome kinetochore
GO:0000779	2.544e-10	0.5318	11 BUB1, BUB1B, C18orf24, CENPE, CENPF, CENPM, DSN1, ERCC6L, KNTC1, SPAG5, SPC25	34	condensed chromosome, centromeric region
GO:0000776	4.163e-10	0.7195	12 BUB1, BUB1B, C18orf24, CENPE, CENPF, CENPM, DSN1, ERCC6L, KNTC1, MAD2L1, SPAG5, SPC25	46	kinetochore
GO:0044446	4.006e-09	42.15	78 ABCA5, ASF1B, AURKB, BARD1, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, C4orf18, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDT1, CENPE, CENPF, CENPI, CENPM, CHAF1A, CHAF1B, CKAP2, DHCR7, DSN1, DTL, ERCC6L, EXOSC9, EZH2, FADS1, GALNAC4S-6ST, GTSE1, INSIG1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, KNTC1, LMNB1, MAD2L1, MCM10, MCM2, MCM4, MCM5, MKI67, NCAPG, NCAPH, OIP5, ORC1L, ORC6L, PKMYT1, POLA1, POLD1, POLE2, POLQ, PRIM1, PRKG1, RASGRP1, RBL1, RFC3, SC4MOL, SCD, SMC2, SPAG5, SPC25, SQLE, SREBF2, TIMELESS, TM7SF2, TPX2, TTK, WDHD1	2695	intracellular organelle part
GO:0044422	4.881e-09	42.31	78 ABCA5, ASF1B, AURKB, BARD1, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, C4orf18, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDT1, CENPE, CENPF, CENPI, CENPM, CHAF1A, CHAF1B, CKAP2, DHCR7, DSN1, DTL, ERCC6L, EXOSC9, EZH2, FADS1, GALNAC4S-6ST, GTSE1, INSIG1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, KNTC1, LMNB1, MAD2L1, MCM10, MCM2, MCM4, MCM5, MKI67, NCAPG, NCAPH, OIP5, ORC1L, ORC6L, PKMYT1, POLA1, POLD1, POLE2, POLQ, PRIM1, PRKG1, RASGRP1, RBL1, RFC3, SC4MOL, SCD, SMC2, SPAG5, SPC25, SQLE, SREBF2, TIMELESS, TM7SF2, TPX2, TTK, WDHD1	2705	organelle part
GO:0043228	1.667e-08	21.12	51 ANK2, ASF1B, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CDC45L, CDC6, CDCA8, CDT1, CENPE, CENPF, CENPI, CENPM, CKAP2, DSN1, ERCC6L, EXOSC9, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, KNTC1, LMNB1, MAD2L1, MCM2, MCM4, MKI67, NCAPG, NCAPH, OIP5, ORC6L, POLA1, PPL, PRIM1, PRKG1, RFC3, SMC2, SPAG5, SPC25, TIMELESS, TPX2, TTK, WDHD1	1350	non-membrane-bounded organelle
GO:0043232	1.667e-08	21.12	51 ANK2, ASF1B, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CDC45L, CDC6, CDCA8, CDT1, CENPE, CENPF, CENPI, CENPM, CKAP2, DSN1, ERCC6L, EXOSC9, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, KNTC1, LMNB1, MAD2L1, MCM2, MCM4, MKI67, NCAPG, NCAPH, OIP5, ORC6L, POLA1, PPL, PRIM1, PRKG1, RFC3, SMC2, SPAG5, SPC25, TIMELESS, TPX2, TTK, WDHD1	1350	intracellular non-membrane-bounded organelle
GO:0015630	3.467e-07	5.036	22 AURKB, BUB1, BUB1B, C18orf24, CDC45L, CDC6, CENPE, CENPF, CKAP2, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, KNTC1, SPAG5, TPX2, TTK	322	microtubule cytoskeleton
GO:0044428	5.937e-06	17.74	41 BARD1, BIRC5, BUB1, BUB1B, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, DHCR7, DTL, EXOSC9, EZH2, KIF20B, KIF4A, LMNB1, MCM10, MCM2, MCM4, MCM5, MKI67, OIP5, ORC1L, ORC6L, PKMYT1, POLA1, POLD1, POLE2, POLQ, PRIM1, PRKG1, RBL1, RFC3, SMC2, TIMELESS, WDHD1	1134	nuclear part
GO:0044430	7.541e-06	6.569	23 AURKB, BUB1, BUB1B, C18orf24, CDC45L, CDC6, CENPE, CENPF, CKAP2, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, KNTC1, LMNB1, SPAG5, TPX2, TTK	420	cytoskeletal part
GO:0005634	9.434e-06	48.35	77 ASF1B, AURKB, BARD1, BIRC5, BRIP1, BUB1, BUB1B, C21orf45, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDT1, CENPE, CENPF, CENPI, CENPM, CHAF1A, CHAF1B, CPA3, DEPDC1, DHCR7, DSN1, DTL, EXO1, EXOSC9, EZH2, FANCG, GINS1, GINS2, GINS3, HELLS, HIVEP1, HJURP, KIF11, KIF14, KIF18A, KIF20B, KIF2C, KIF4A, KNTC1, LMCD1, LMNB1, MAD2L1, MCM10, MCM2, MCM4, MCM5, MKI67, NCAPG, NCAPH, NEIL3, OIP5, ORC1L, ORC6L, PKMYT1, POLA1, POLD1, POLE2, POLQ, PPL, PRIM1, PRKG1, PSMC3IP, RAD54B, RBL1, RFC3, RNASEH2A, SMC2, SPC25, SREBF2, TIMELESS, TPX2, WDHD1	3091	nucleus
GO:0005654	9.765e-06	8.915	27 CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDK2, CDT1, CHAF1A, CHAF1B, EZH2, KIF20B, MCM10, MCM2, MCM4, MCM5, OIP5, ORC1L, ORC6L, PKMYT1, POLA1, POLD1, POLE2, POLQ, PRIM1, RBL1, RFC3, WDHD1	570	nucleoplasm
GO:0031981	1.510e-05	13.53	34 BIRC5, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, EXOSC9, EZH2, KIF20B, KIF4A, LMNB1, MCM10, MCM2, MCM4, MCM5, MKI67, OIP5, ORC1L, ORC6L, PKMYT1, POLA1, POLD1, POLE2, POLQ, PRIM1, PRKG1, RBL1, RFC3, WDHD1	865	nuclear lumen
GO:0005874	2.913e-05	2.315	13 CENPE, CKAP2, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, KNTC1, SPAG5	148	microtubule
GO:0005875	4.464e-05	1.032	9 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A	66	microtubule associated complex
GO:0043234	6.022e-05	18.69	40 BARD1, BIRC5, BUB1, BUB1B, C18orf24, CDCA8, CDK2, CENPE, CENPF, CENPM, CHAF1A, CHAF1B, DSN1, ERCC6L, EXOSC9, EZH2, IL6, KCND3, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, KNTC1, MAD2L1, MCM2, NCAPG, NCAPH, ORC6L, POLA1, PRIM1, RBL1, RFC3, SMC2, SPAG5, SPC25, TGFBR1	1195	protein complex
GO:0000940	1.962e-04	0.04692	3 BUB1B, CENPE, CENPF	3	outer kinetochore of condensed chromosome
GO:0000922	5.165e-04	0.3128	5 BUB1, CENPF, KIF11, KNTC1, TPX2	20	spindle pole
GO:0070013	9.595e-04	16.56	34 BIRC5, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, EXOSC9, EZH2, KIF20B, KIF4A, LMNB1, MCM10, MCM2, MCM4, MCM5, MKI67, OIP5, ORC1L, ORC6L, PKMYT1, POLA1, POLD1, POLE2, POLQ, PRIM1, PRKG1, RBL1, RFC3, WDHD1	1059	intracellular organelle lumen
GO:0005856	9.724e-04	10.93	26 ANK2, AURKB, BUB1, BUB1B, C18orf24, CDC45L, CDC6, CENPE, CENPF, CKAP2, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, KNTC1, LMNB1, NCAPH, PPL, SPAG5, TPX2, TTK	699	cytoskeleton
GO:0043233	1.294e-03	16.83	34 BIRC5, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, EXOSC9, EZH2, KIF20B, KIF4A, LMNB1, MCM10, MCM2, MCM4, MCM5, MKI67, OIP5, ORC1L, ORC6L, PKMYT1, POLA1, POLD1, POLE2, POLQ, PRIM1, PRKG1, RBL1, RFC3, WDHD1	1076	organelle lumen
GO:0031974	1.966e-03	17.22	34 BIRC5, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, EXOSC9, EZH2, KIF20B, KIF4A, LMNB1, MCM10, MCM2, MCM4, MCM5, MKI67, OIP5, ORC1L, ORC6L, PKMYT1, POLA1, POLD1, POLE2, POLQ, PRIM1, PRKG1, RBL1, RFC3, WDHD1	1101	membrane-enclosed lumen
GO:0000796	2.661e-03	0.09384	3 NCAPG, NCAPH, SMC2	6	condensin complex
GO:0005876	4.963e-03	0.2815	4 KIF11, KIF4A, KNTC1, SPAG5	18	spindle microtubule
GO:0000228	6.103e-03	1.204	7 BUB1, MCM2, ORC6L, POLA1, PRIM1, SMC2, TIMELESS	77	nuclear chromosome
GO:0044454	7.711e-03	0.8915	6 BUB1, MCM2, ORC6L, POLA1, PRIM1, TIMELESS	57	nuclear chromosome part
GO:0032991	1.285e-02	24.1	40 BARD1, BIRC5, BUB1, BUB1B, C18orf24, CDCA8, CDK2, CENPE, CENPF, CENPM, CHAF1A, CHAF1B, DSN1, ERCC6L, EXOSC9, EZH2, IL6, KCND3, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, KNTC1, MAD2L1, MCM2, NCAPG, NCAPH, ORC6L, POLA1, PRIM1, RBL1, RFC3, SMC2, SPAG5, SPC25, TGFBR1	1541	macromolecular complex
GO:0005871	1.585e-02	0.172	3 KIF11, KIF15, KIF2C	11	kinesin complex
GO:0005657	1.800e-02	0.4067	4 CDT1, POLA1, PRIM1, RFC3	26	replication fork
GO:0043226	2.863e-02	82.1	98 ABCA5, ANK2, ASF1B, AURKB, BARD1, BIRC5, BRIP1, BUB1, BUB1B, C18orf24, C21orf45, C4orf18, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDT1, CENPE, CENPF, CENPI, CENPM, CHAF1A, CHAF1B, CKAP2, CPA3, DEPDC1, DHCR7, DSN1, DTL, ERCC6L, EXO1, EXOSC9, EZH2, FADS1, FANCG, GALNAC4S-6ST, GINS1, GINS2, GINS3, GTSE1, HELLS, HIVEP1, HJURP, IDI1, IL1B, INSIG1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, KNTC1, LMCD1, LMNB1, MAD2L1, MCM10, MCM2, MCM4, MCM5, MKI67, NCAPG, NCAPH, NEIL3, OIP5, ORC1L, ORC6L, PKMYT1, POLA1, POLD1, POLE2, POLQ, PPL, PRIM1, PRKG1, PSMC3IP, RAD54B, RASGRP1, RBL1, RFC3, RNASEH2A, SC4MOL, SCD, SMC2, SPAG5, SPC25, SQLE, SREBF2, TIMELESS, TM7SF2, TPX2, TTK, WDHD1	5249	organelle
GO:0005664	3.415e-02	0.06256	2 MCM2, ORC6L	4	nuclear origin of replication recognition complex
GO:0044424	4.369e-02	97.13	110 ABCA5, ANK2, ASF1B, AURKB, BARD1, BIRC5, BRIP1, BUB1, BUB1B, C18orf24, C21orf45, C4orf18, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDT1, CENPE, CENPF, CENPI, CENPM, CHAF1A, CHAF1B, CIT, CKAP2, COL21A1, CPA3, DEPDC1, DHCR7, DSN1, DTL, ERCC6L, EXO1, EXOSC9, EZH2, FABP3, FADS1, FANCG, GALNAC4S-6ST, GINS1, GINS2, GINS3, GTSE1, HELLS, HERC6, HIVEP1, HJURP, ICAM1, IDI1, INSIG1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, KNTC1, LMCD1, LMNB1, MAD2L1, MCM10, MCM2, MCM4, MCM5, MKI67, MVD, NCAPG, NCAPH, NEIL3, OIP5, ORC1L, ORC6L, PKMYT1, POLA1, POLD1, POLE2, POLQ, PPL, PPP3CC, PRIM1, PRKG1, PSMC3IP, QPRT, RAD54B, RASGRP1, RBL1, RFC3, RNASEH2A, SC4MOL, SCD, SLC2A14, SMC2, SPAG5, SPC25, SQLE, SREBF2, STIL, STK38L, TACC3, TACSTD2, TIMELESS, TM7SF2, TPX2, TTK, WDHD1	6210	intracellular part
GO:0043229	4.874e-02	82.08	97 ABCA5, ANK2, ASF1B, AURKB, BARD1, BIRC5, BRIP1, BUB1, BUB1B, C18orf24, C21orf45, C4orf18, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDT1, CENPE, CENPF, CENPI, CENPM, CHAF1A, CHAF1B, CKAP2, CPA3, DEPDC1, DHCR7, DSN1, DTL, ERCC6L, EXO1, EXOSC9, EZH2, FADS1, FANCG, GALNAC4S-6ST, GINS1, GINS2, GINS3, GTSE1, HELLS, HIVEP1, HJURP, IDI1, INSIG1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, KNTC1, LMCD1, LMNB1, MAD2L1, MCM10, MCM2, MCM4, MCM5, MKI67, NCAPG, NCAPH, NEIL3, OIP5, ORC1L, ORC6L, PKMYT1, POLA1, POLD1, POLE2, POLQ, PPL, PRIM1, PRKG1, PSMC3IP, RAD54B, RASGRP1, RBL1, RFC3, RNASEH2A, SC4MOL, SCD, SMC2, SPAG5, SPC25, SQLE, SREBF2, TIMELESS, TM7SF2, TPX2, TTK, WDHD1	5248	intracellular organelle

Id	Pvalue	ExpCount	Count	Size	Term
GO:0030554	8.727e-07	12.52	37 ABCA5, AURKB, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CIT, ERCC6L, GALNAC4S-6ST, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, MCM2, MCM5, MKI67, MVD, ORC1L, PDGFRB, PKMYT1, POLQ, PRKG1, RAD54B, SMC2, SQLE, STK38L, TGFBR1, TPX2, TTK	864	adenyl nucleotide binding
GO:0005524	1.902e-06	11.72	35 ABCA5, AURKB, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CIT, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, MCM2, MCM5, MKI67, MVD, ORC1L, PDGFRB, PKMYT1, POLQ, PRKG1, RAD54B, SMC2, STK38L, TGFBR1, TPX2, TTK	809	ATP binding
GO:0032559	2.381e-06	11.85	35 ABCA5, AURKB, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CIT, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, MCM2, MCM5, MKI67, MVD, ORC1L, PDGFRB, PKMYT1, POLQ, PRKG1, RAD54B, SMC2, STK38L, TGFBR1, TPX2, TTK	818	adenyl ribonucleotide binding
GO:0003777	2.638e-06	0.536	9 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A	37	microtubule motor activity
GO:0017076	6.259e-05	15.35	37 ABCA5, AURKB, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CIT, ERCC6L, GALNAC4S-6ST, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, MCM2, MCM5, MKI67, MVD, ORC1L, PDGFRB, PKMYT1, POLQ, PRKG1, RAD54B, SMC2, SQLE, STK38L, TGFBR1, TPX2, TTK	1060	purine nucleotide binding
GO:0000166	8.612e-05	18.47	41 ABCA5, AURKB, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CIT, ERCC6L, GALNAC4S-6ST, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, MCM2, MCM4, MCM5, MKI67, MVD, ORC1L, PDGFRB, PKMYT1, POLA1, POLD1, POLQ, PRKG1, RAD54B, RFC3, SMC2, SQLE, STK38L, TGFBR1, TPX2, TTK	1275	nucleotide binding
GO:0032553	1.513e-04	14.66	35 ABCA5, AURKB, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CIT, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, MCM2, MCM5, MKI67, MVD, ORC1L, PDGFRB, PKMYT1, POLQ, PRKG1, RAD54B, SMC2, STK38L, TGFBR1, TPX2, TTK	1012	ribonucleotide binding
GO:0032555	1.513e-04	14.66	35 ABCA5, AURKB, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CIT, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, MCM2, MCM5, MKI67, MVD, ORC1L, PDGFRB, PKMYT1, POLQ, PRKG1, RAD54B, SMC2, STK38L, TGFBR1, TPX2, TTK	1012	purine ribonucleotide binding
GO:0003774	2.462e-04	1.028	9 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A	71	motor activity
GO:0017111	9.758e-03	6.533	18 ABCA5, BRIP1, CDC6, CENPE, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, MCM4, ORC1L, RAD54B, RFC3	451	nucleoside-triphosphatase activity
GO:0003887	1.290e-02	0.2607	4 POLA1, POLD1, POLE2, POLQ	18	DNA-directed DNA polymerase activity
GO:0016462	1.444e-02	6.808	18 ABCA5, BRIP1, CDC6, CENPE, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, MCM4, ORC1L, RAD54B, RFC3	470	pyrophosphatase activity
GO:0016818	1.507e-02	6.837	18 ABCA5, BRIP1, CDC6, CENPE, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, MCM4, ORC1L, RAD54B, RFC3	472	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016817	1.532e-02	6.852	18 ABCA5, BRIP1, CDC6, CENPE, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20B, KIF2C, KIF4A, MCM4, ORC1L, RAD54B, RFC3	473	hydrolase activity, acting on acid anhydrides
GO:0003682	1.705e-02	1.173	7 CDC6, CENPF, CHAF1A, CHAF1B, HELLS, POLA1, POLD1	81	chromatin binding
GO:0034061	2.073e-02	0.3042	4 POLA1, POLD1, POLE2, POLQ	21	DNA polymerase activity
GO:0003896	4.449e-02	0.04346	2 POLA1, PRIM1	3	DNA primase activity

Id	Pvalue	ExpCount	Count	Size	Term
04110	3.318e-09	1.869	16 BUB1, BUB1B, CCNA2, CCNE2, CDC45L, CDC6, CDC7, CDK2, MAD2L1, MCM2, MCM4, MCM5, ORC1L, ORC6L, PKMYT1, RBL1	98	Cell cycle
03030	1.273e-06	0.6295	9 MCM2, MCM4, MCM5, POLA1, POLD1, POLE2, PRIM1, RFC3, RNASEH2A	33	DNA replication
00100	2.722e-05	0.4387	7 DHCR7, IDI1, LSS, MVD, SC4MOL, SQLE, TM7SF2	23	Biosynthesis of steroids

No enriched terms

No enriched terms

Entrez genes

ABCA5ATP-binding cassette, sub-family A (ABC1), member 5 (213353_at), score: 0.76 ANK2ankyrin 2, neuronal (202920_at), score: 0.82 ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae) (218115_at), score: -0.71 AURKBaurora kinase B (209464_at), score: -0.74 BARD1BRCA1 associated RING domain 1 (205345_at), score: -0.73 BIRC5baculoviral IAP repeat-containing 5 (202095_s_at), score: -0.7 BRIP1BRCA1 interacting protein C-terminal helicase 1 (221703_at), score: -0.75 BUB1budding uninhibited by benzimidazoles 1 homolog (yeast) (209642_at), score: -0.75 BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast) (203755_at), score: -0.72 C17orf91chromosome 17 open reading frame 91 (214696_at), score: 0.82 C18orf24chromosome 18 open reading frame 24 (217640_x_at), score: -0.75 C1orf135chromosome 1 open reading frame 135 (220011_at), score: -0.74 C21orf45chromosome 21 open reading frame 45 (219004_s_at), score: -0.78 C4orf18chromosome 4 open reading frame 18 (219872_at), score: 0.77 CCL11chemokine (C-C motif) ligand 11 (210133_at), score: 0.82 CCNA2cyclin A2 (203418_at), score: -0.72 CCNE2cyclin E2 (205034_at), score: -0.75 CDC45LCDC45 cell division cycle 45-like (S. cerevisiae) (204126_s_at), score: -0.73 CDC6cell division cycle 6 homolog (S. cerevisiae) (203967_at), score: -0.76 CDC7cell division cycle 7 homolog (S. cerevisiae) (204510_at), score: -0.8 CDCA8cell division cycle associated 8 (221520_s_at), score: -0.74 CDK2cyclin-dependent kinase 2 (204252_at), score: -0.78 CDT1chromatin licensing and DNA replication factor 1 (209832_s_at), score: -0.7 CENPEcentromere protein E, 312kDa (205046_at), score: -0.72 CENPFcentromere protein F, 350/400ka (mitosin) (207828_s_at), score: -0.71 CENPIcentromere protein I (214804_at), score: -0.71 CENPMcentromere protein M (218741_at), score: -0.78 CHAF1Achromatin assembly factor 1, subunit A (p150) (214426_x_at), score: -0.74 CHAF1Bchromatin assembly factor 1, subunit B (p60) (204775_at), score: -0.71 CITcitron (rho-interacting, serine/threonine kinase 21) (212801_at), score: -0.69 CKAP2cytoskeleton associated protein 2 (218252_at), score: -0.75 COL14A1collagen, type XIV, alpha 1 (212865_s_at), score: 0.82 COL21A1collagen, type XXI, alpha 1 (208096_s_at), score: 0.86 CORINcorin, serine peptidase (220356_at), score: 0.77 CPA3carboxypeptidase A3 (mast cell) (205624_at), score: 0.91 DEPDC1DEP domain containing 1 (220295_x_at), score: -0.76 DHCR77-dehydrocholesterol reductase (201790_s_at), score: 0.91 DLEU2deleted in lymphocytic leukemia 2 (non-protein coding) (216870_x_at), score: -0.72 DLEU2Ldeleted in lymphocytic leukemia 2-like (215629_s_at), score: -0.75 DSN1DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) (219512_at), score: -0.89 DTLdenticleless homolog (Drosophila) (218585_s_at), score: -0.73 ECM2extracellular matrix protein 2, female organ and adipocyte specific (206101_at), score: 0.76 ERCC6Lexcision repair cross-complementing rodent repair deficiency, complementation group 6-like (219650_at), score: -0.73 ERI2exoribonuclease 2 (213365_at), score: -0.7 EXO1exonuclease 1 (204603_at), score: -0.71 EXOSC9exosome component 9 (205061_s_at), score: -0.73 EZH2enhancer of zeste homolog 2 (Drosophila) (203358_s_at), score: -0.83 FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (214285_at), score: 1 FADS1fatty acid desaturase 1 (208962_s_at), score: 0.79 FANCGFanconi anemia, complementation group G (203564_at), score: -0.72 FRYfurry homolog (Drosophila) (204072_s_at), score: 0.88 GALNAC4S-6STB cell RAG associated protein (203066_at), score: 0.8 GINS1GINS complex subunit 1 (Psf1 homolog) (206102_at), score: -0.73 GINS2GINS complex subunit 2 (Psf2 homolog) (221521_s_at), score: -0.76 GINS3GINS complex subunit 3 (Psf3 homolog) (45633_at), score: -0.79 GTSE1G-2 and S-phase expressed 1 (204318_s_at), score: -0.71 HELLShelicase, lymphoid-specific (220085_at), score: -0.74 HERC6hect domain and RLD 6 (219352_at), score: 0.76 HIVEP1human immunodeficiency virus type I enhancer binding protein 1 (204512_at), score: 0.75 HJURPHolliday junction recognition protein (218726_at), score: -0.72 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: 0.83 IDI1isopentenyl-diphosphate delta isomerase 1 (204615_x_at), score: 0.84 IL1Binterleukin 1, beta (39402_at), score: 0.77 IL6interleukin 6 (interferon, beta 2) (205207_at), score: 0.76 INSIG1insulin induced gene 1 (201627_s_at), score: 0.95 KCND3potassium voltage-gated channel, Shal-related subfamily, member 3 (213832_at), score: 0.88 KIF11kinesin family member 11 (204444_at), score: -0.74 KIF14kinesin family member 14 (206364_at), score: -0.76 KIF15kinesin family member 15 (219306_at), score: -0.72 KIF18Akinesin family member 18A (221258_s_at), score: -0.71 KIF18Bkinesin family member 18B (222039_at), score: -0.83 KIF20Bkinesin family member 20B (205235_s_at), score: -0.7 KIF2Ckinesin family member 2C (209408_at), score: -0.71 KIF4Akinesin family member 4A (218355_at), score: -0.76 KNTC1kinetochore associated 1 (206316_s_at), score: -0.72 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: 0.82 LMNB1lamin B1 (203276_at), score: -0.74 LOH3CR2Aloss of heterozygosity, 3, chromosomal region 2, gene A (220244_at), score: 0.77 LSSlanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (211019_s_at), score: 0.9 MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast) (203362_s_at), score: -0.77 MCM10minichromosome maintenance complex component 10 (220651_s_at), score: -0.84 MCM2minichromosome maintenance complex component 2 (202107_s_at), score: -0.7 MCM4minichromosome maintenance complex component 4 (212141_at), score: -0.7 MCM5minichromosome maintenance complex component 5 (216237_s_at), score: -0.72 MKI67antigen identified by monoclonal antibody Ki-67 (212022_s_at), score: -0.71 MVDmevalonate (diphospho) decarboxylase (203027_s_at), score: 0.84 NCAPGnon-SMC condensin I complex, subunit G (218663_at), score: -0.71 NCAPHnon-SMC condensin I complex, subunit H (212949_at), score: -0.71 NEIL3nei endonuclease VIII-like 3 (E. coli) (219502_at), score: -0.7 OIP5Opa interacting protein 5 (213599_at), score: -0.74 ORC1Lorigin recognition complex, subunit 1-like (yeast) (205085_at), score: -0.73 ORC6Lorigin recognition complex, subunit 6 like (yeast) (219105_x_at), score: -0.83 PAPPApregnancy-associated plasma protein A, pappalysin 1 (201981_at), score: 0.77 PDGFRBplatelet-derived growth factor receptor, beta polypeptide (202273_at), score: 0.77 PKMYT1protein kinase, membrane associated tyrosine/threonine 1 (204267_x_at), score: -0.7 PLXNC1plexin C1 (213241_at), score: 0.82 POLA1polymerase (DNA directed), alpha 1, catalytic subunit (204835_at), score: -0.8 POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa (203422_at), score: -0.72 POLE2polymerase (DNA directed), epsilon 2 (p59 subunit) (205909_at), score: -0.78 POLQpolymerase (DNA directed), theta (219510_at), score: -0.73 PPLperiplakin (203407_at), score: 0.95 PPP3CCprotein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (207000_s_at), score: 0.79 PRIM1primase, DNA, polypeptide 1 (49kDa) (205053_at), score: -0.81 PRKG1protein kinase, cGMP-dependent, type I (207119_at), score: 0.92 PSMC3IPPSMC3 interacting protein (213951_s_at), score: -0.77 QPRTquinolinate phosphoribosyltransferase (204044_at), score: 0.84 RAD54BRAD54 homolog B (S. cerevisiae) (219494_at), score: -0.8 RASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated) (205590_at), score: 0.86 RBL1retinoblastoma-like 1 (p107) (205296_at), score: -0.75 RFC3replication factor C (activator 1) 3, 38kDa (204127_at), score: -0.77 RNASEH2Aribonuclease H2, subunit A (203022_at), score: -0.7 SC4MOLsterol-C4-methyl oxidase-like (209146_at), score: 0.95 SCDstearoyl-CoA desaturase (delta-9-desaturase) (200832_s_at), score: 0.85 SLC2A14solute carrier family 2 (facilitated glucose transporter), member 14 (222088_s_at), score: 0.85 SLC2A3P1solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 1 (221751_at), score: 0.79 SMC2structural maintenance of chromosomes 2 (204240_s_at), score: -0.71 SPAG5sperm associated antigen 5 (203145_at), score: -0.73 SPC25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) (209891_at), score: -0.71 SQLEsqualene epoxidase (213562_s_at), score: 0.97 SREBF2sterol regulatory element binding transcription factor 2 (201247_at), score: 0.84 STILSCL/TAL1 interrupting locus (205339_at), score: -0.74 STK38Lserine/threonine kinase 38 like (212572_at), score: 0.84 TACC3transforming, acidic coiled-coil containing protein 3 (218308_at), score: -0.72 TACSTD2tumor-associated calcium signal transducer 2 (202286_s_at), score: 0.88 TGFBR1transforming growth factor, beta receptor 1 (206943_at), score: 0.77 TIMELESStimeless homolog (Drosophila) (203046_s_at), score: -0.73 TM7SF2transmembrane 7 superfamily member 2 (210130_s_at), score: 0.84 TMEM194Atransmembrane protein 194A (212621_at), score: -0.82 TPX2TPX2, microtubule-associated, homolog (Xenopus laevis) (210052_s_at), score: -0.7 TTC17tetratricopeptide repeat domain 17 (218972_at), score: 0.75 TTKTTK protein kinase (204822_at), score: -0.8 WDHD1WD repeat and HMG-box DNA binding protein 1 (216228_s_at), score: -0.7

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
E-TABM-263-raw-cel-1515486291.cel	33	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486271.cel	32	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486351.cel	36	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486331.cel	35	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486231.cel	30	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515485851.cel	11	6	Cycle	hgu133a2	none	Cycle 1