Under-expression is coded with green,
over-expression with red color.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
intermediate filament
A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
extracellular space
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
cytoskeleton
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
neurofilament
A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter.
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
intermediate filament cytoskeleton
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
neurofilament cytoskeleton
Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons.
all
This term is the most general term possible
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
intermediate filament
A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.
neurofilament
A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter.
purinergic nucleotide receptor activity
Combining with a purine nucleotide to initiate a change in cell activity.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
signal transducer activity
Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.
receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
transmembrane receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
nucleotide receptor activity
Combining with a nucleotide to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule.
molecular transducer activity
The molecular function that accepts an input of one form and creates an output of a different form.
all
This term is the most general term possible
Id | Pvalue | ExpCount | Count | Size | Term |
---|---|---|---|---|---|
04080 | 2.184e-03 | 0.883 | 7 | 83 | Neuroactive ligand-receptor interaction |
ACTR3BARP3 actin-related protein 3 homolog B (yeast) (218868_at), score: -0.65 ADORA2Badenosine A2b receptor (205891_at), score: 0.67 AHI1Abelson helper integration site 1 (221569_at), score: -0.81 AIM1absent in melanoma 1 (212543_at), score: 0.68 AJAP1adherens junctions associated protein 1 (206460_at), score: -0.66 ANXA10annexin A10 (210143_at), score: -0.84 BMP6bone morphogenetic protein 6 (206176_at), score: -1 C14orf45chromosome 14 open reading frame 45 (220173_at), score: -0.73 C2CD2C2 calcium-dependent domain containing 2 (212875_s_at), score: -0.7 CALB2calbindin 2 (205428_s_at), score: -0.62 CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group) (201925_s_at), score: -0.8 CDC2L6cell division cycle 2-like 6 (CDK8-like) (212899_at), score: 0.68 CDCA3cell division cycle associated 3 (221436_s_at), score: 0.65 CDKN3cyclin-dependent kinase inhibitor 3 (209714_s_at), score: 0.68 CENPFcentromere protein F, 350/400ka (mitosin) (207828_s_at), score: 0.65 CEP68centrosomal protein 68kDa (212677_s_at), score: 0.67 CLEC3BC-type lectin domain family 3, member B (205200_at), score: -0.64 COL5A3collagen, type V, alpha 3 (52255_s_at), score: -0.7 CSGALNACT2chondroitin sulfate N-acetylgalactosaminyltransferase 2 (222235_s_at), score: -0.63 CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) (206336_at), score: -0.79 DENND5BDENN/MADD domain containing 5B (215058_at), score: -0.69 DIRAS3DIRAS family, GTP-binding RAS-like 3 (215506_s_at), score: -0.66 DIS3DIS3 mitotic control homolog (S. cerevisiae) (218362_s_at), score: -0.69 DNAJB9DnaJ (Hsp40) homolog, subfamily B, member 9 (202843_at), score: -0.91 DUSP4dual specificity phosphatase 4 (204014_at), score: -0.64 ENTPD7ectonucleoside triphosphate diphosphohydrolase 7 (220153_at), score: -0.64 ESM1endothelial cell-specific molecule 1 (208394_x_at), score: -0.9 ESRRAestrogen-related receptor alpha (1487_at), score: -0.67 EVI2Aecotropic viral integration site 2A (204774_at), score: 0.67 EVI2Becotropic viral integration site 2B (211742_s_at), score: 0.67 FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (214285_at), score: -0.67 FBXO31F-box protein 31 (219785_s_at), score: 0.73 FERMT1fermitin family homolog 1 (Drosophila) (218796_at), score: -0.88 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: -0.69 FICDFIC domain containing (219910_at), score: -0.66 FOXM1forkhead box M1 (202580_x_at), score: 0.68 GHRgrowth hormone receptor (205498_at), score: -0.63 GKglycerol kinase (207387_s_at), score: -0.93 GK3Pglycerol kinase 3 pseudogene (215966_x_at), score: -0.94 GPR177G protein-coupled receptor 177 (221958_s_at), score: -0.71 GPR183G protein-coupled receptor 183 (205419_at), score: -0.71 GPSM2G-protein signaling modulator 2 (AGS3-like, C. elegans) (221922_at), score: 0.65 GRB14growth factor receptor-bound protein 14 (206204_at), score: -0.77 HDGFhepatoma-derived growth factor (high-mobility group protein 1-like) (200896_x_at), score: 0.65 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (207135_at), score: -0.84 IL11interleukin 11 (206924_at), score: -0.63 IL13RA2interleukin 13 receptor, alpha 2 (206172_at), score: -0.62 IL33interleukin 33 (209821_at), score: -0.94 IRGQimmunity-related GTPase family, Q (64488_at), score: -0.62 KAL1Kallmann syndrome 1 sequence (205206_at), score: -0.92 KCNG1potassium voltage-gated channel, subfamily G, member 1 (214595_at), score: -0.68 KLHL21kelch-like 21 (Drosophila) (203068_at), score: -0.65 LRP8low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (205282_at), score: -0.63 MFAP3Lmicrofibrillar-associated protein 3-like (205442_at), score: -0.65 MLXIPMLX interacting protein (202519_at), score: -0.66 MMP10matrix metallopeptidase 10 (stromelysin 2) (205680_at), score: -0.81 MREGmelanoregulin (219648_at), score: -0.68 MTMR9myotubularin related protein 9 (204837_at), score: -0.64 NCALDneurocalcin delta (211685_s_at), score: -0.78 NCAPD2non-SMC condensin I complex, subunit D2 (201774_s_at), score: 0.7 NEFLneurofilament, light polypeptide (221805_at), score: -0.71 NEFMneurofilament, medium polypeptide (205113_at), score: -0.78 NOX4NADPH oxidase 4 (219773_at), score: -0.63 NPTX1neuronal pentraxin I (204684_at), score: -0.69 NRXN3neurexin 3 (205795_at), score: -0.64 OPCMLopioid binding protein/cell adhesion molecule-like (214111_at), score: -0.73 P2RX5purinergic receptor P2X, ligand-gated ion channel, 5 (210448_s_at), score: -0.66 PCDH9protocadherin 9 (219737_s_at), score: -0.83 PCTK2PCTAIRE protein kinase 2 (221918_at), score: -0.64 PID1phosphotyrosine interaction domain containing 1 (219093_at), score: -0.66 PIGHphosphatidylinositol glycan anchor biosynthesis, class H (209625_at), score: -0.63 PRSS1protease, serine, 1 (trypsin 1) (216470_x_at), score: -0.65 PRSS3protease, serine, 3 (207463_x_at), score: -0.73 PTHLHparathyroid hormone-like hormone (211756_at), score: -0.87 PTPRBprotein tyrosine phosphatase, receptor type, B (205846_at), score: -0.67 PTTG1pituitary tumor-transforming 1 (203554_x_at), score: 0.65 PTTG3pituitary tumor-transforming 3 (208511_at), score: 0.67 RAB6CRAB6C, member RAS oncogene family (210406_s_at), score: -0.67 RFX5regulatory factor X, 5 (influences HLA class II expression) (202963_at), score: 0.8 RNF44ring finger protein 44 (203286_at), score: 0.71 SLC38A4solute carrier family 38, member 4 (220786_s_at), score: 0.73 SLC4A7solute carrier family 4, sodium bicarbonate cotransporter, member 7 (209884_s_at), score: -0.71 SLMO2slowmo homolog 2 (Drosophila) (217851_s_at), score: -0.66 SMAD3SMAD family member 3 (218284_at), score: 0.71 SPA17sperm autoantigenic protein 17 (205406_s_at), score: 0.7 SSTR1somatostatin receptor 1 (208482_at), score: -0.62 TFDP2transcription factor Dp-2 (E2F dimerization partner 2) (203588_s_at), score: 0.94 TGDSTDP-glucose 4,6-dehydratase (208249_s_at), score: -0.67 TGFAtransforming growth factor, alpha (205016_at), score: -0.68 TMEM2transmembrane protein 2 (218113_at), score: -0.72 TMSB15Athymosin beta 15a (205347_s_at), score: 0.75 TMSB15Bthymosin beta 15B (214051_at), score: 0.68 UCP2uncoupling protein 2 (mitochondrial, proton carrier) (208998_at), score: 0.77 VWA5Avon Willebrand factor A domain containing 5A (210102_at), score: 0.65 WDR6WD repeat domain 6 (217734_s_at), score: 0.67
Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
---|---|---|---|---|---|---|
E-TABM-263-raw-cel-1515485811.cel | 9 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
E-TABM-263-raw-cel-1515485891.cel | 13 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
E-TABM-263-raw-cel-1515486371.cel | 37 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
E-TABM-263-raw-cel-1515486351.cel | 36 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
E-TABM-263-raw-cel-1515485851.cel | 11 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
E-GEOD-3860-raw-cel-1561690199.cel | 1 | 5 | HGPS | hgu133a | none | GM0316B |
E-TABM-263-raw-cel-1515485771.cel | 7 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
E-TABM-263-raw-cel-1515485671.cel | 2 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
E-TABM-263-raw-cel-1515486051.cel | 21 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
E-TABM-263-raw-cel-1515485831.cel | 10 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
E-TABM-263-raw-cel-1515486011.cel | 19 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
E-TABM-263-raw-cel-1515486191.cel | 28 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
E-TABM-263-raw-cel-1515486391.cel | 38 | 6 | Cycle | hgu133a2 | none | Cycle 1 |