Previous module | Next module Module #890, TG: 2.2, TC: 2, 266 probes, 266 Entrez genes, 7 conditions

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Expression data for module #890

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

blood vessel development

The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

vasculature development

The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

regulation of leukocyte migration

Any process that modulates the frequency, rate, or extent of leukocyte migration.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

cell motion

Any process involved in the controlled movement of a cell.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

cell surface receptor linked signal transduction

Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.

intracellular signaling cascade

A series of reactions within the cell that occur as a result of a single trigger reaction or compound.

protein kinase cascade

A series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

behavior

The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

cell migration

The orderly movement of cells from one site to another, often during the development of a multicellular organism or multicellular structure.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

locomotion

Self-propelled movement of a cell or organism from one location to another.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

localization of cell

Any process by which a cell is transported to, and/or maintained in, a specific location.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

all

This term is the most general term possible

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of leukocyte migration

Any process that modulates the frequency, rate, or extent of leukocyte migration.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

cell motion

Any process involved in the controlled movement of a cell.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

regulation of leukocyte migration

Any process that modulates the frequency, rate, or extent of leukocyte migration.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

Help | Hide | Top The GO tree — Cellular Components

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plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

MHC class I protein complex

A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

proteinaceous extracellular matrix

A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

extracellular matrix

A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants).

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

all

This term is the most general term possible

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

Help | Hide | Top The GO tree — Molecular Function

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protein binding

Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

receptor binding

Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transmembrane receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

MHC class I receptor activity

Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

This term is the most general term possible

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04610 2.564e-03 1.247 8
34 Complement and coagulation cascades
04060 2.982e-03 4.475 15
122 Cytokine-cytokine receptor interaction
05332 7.326e-03 0.7704 6
21 Graft-versus-host disease
04630 2.114e-02 3.228 11
88 Jak-STAT signaling pathway
05330 4.414e-02 0.7704 5
21 Allograft rejection

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ABLIM3actin binding LIM protein family, member 3 (205730_s_at), score: -0.21 ACSL1acyl-CoA synthetase long-chain family member 1 (201963_at), score: -0.2 ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide (209612_s_at), score: -0.24 ADRA2Aadrenergic, alpha-2A-, receptor (209869_at), score: -0.34 AEBP1AE binding protein 1 (201792_at), score: -0.21 AJAP1adherens junctions associated protein 1 (206460_at), score: -0.27 AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (209160_at), score: -0.21 ANGPTL4angiopoietin-like 4 (221009_s_at), score: -0.33 ANO1anoctamin 1, calcium activated chloride channel (218804_at), score: -0.26 APODapolipoprotein D (201525_at), score: -0.27 AQP1aquaporin 1 (Colton blood group) (209047_at), score: -0.26 ARID5AAT rich interactive domain 5A (MRF1-like) (213138_at), score: -0.18 ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (206414_s_at), score: -0.27 ATP13A3ATPase type 13A3 (219558_at), score: -0.18 B4GALT6UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 (206233_at), score: 0.62 BDKRB1bradykinin receptor B1 (207510_at), score: -0.19 BMP2bone morphogenetic protein 2 (205289_at), score: -0.18 C11orf20chromosome 11 open reading frame 20 (219883_at), score: 0.63 C17orf91chromosome 17 open reading frame 91 (214696_at), score: -0.23 C19orf28chromosome 19 open reading frame 28 (220178_at), score: -0.19 C1orf159chromosome 1 open reading frame 159 (219337_at), score: 0.59 C1Rcomplement component 1, r subcomponent (212067_s_at), score: -0.38 C1Scomplement component 1, s subcomponent (208747_s_at), score: -0.27 C20orf27chromosome 20 open reading frame 27 (50314_i_at), score: 0.61 C9orf167chromosome 9 open reading frame 167 (219620_x_at), score: -0.2 C9orf33chromosome 9 open reading frame 33 (217130_at), score: 0.59 CADPS2Ca++-dependent secretion activator 2 (219572_at), score: -0.21 CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (211368_s_at), score: -0.22 CASP4caspase 4, apoptosis-related cysteine peptidase (209310_s_at), score: -0.22 CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b (209682_at), score: -0.23 CCL2chemokine (C-C motif) ligand 2 (216598_s_at), score: -0.29 CCRL1chemokine (C-C motif) receptor-like 1 (220351_at), score: -0.4 CD302CD302 molecule (203799_at), score: -0.32 CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group) (201925_s_at), score: -0.26 CD97CD97 molecule (202910_s_at), score: -0.24 CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae) (208022_s_at), score: -0.18 CDC42SE1CDC42 small effector 1 (218157_x_at), score: -0.27 CLEC2BC-type lectin domain family 2, member B (209732_at), score: -0.34 CLEC7AC-type lectin domain family 7, member A (221698_s_at), score: 0.65 COL13A1collagen, type XIII, alpha 1 (211343_s_at), score: -0.18 COL14A1collagen, type XIV, alpha 1 (212865_s_at), score: -0.3 COL15A1collagen, type XV, alpha 1 (203477_at), score: -0.47 CPZcarboxypeptidase Z (211062_s_at), score: -0.2 CREG1cellular repressor of E1A-stimulated genes 1 (201200_at), score: -0.41 CRHR1corticotropin releasing hormone receptor 1 (208593_x_at), score: 0.59 CSF1colony stimulating factor 1 (macrophage) (209716_at), score: -0.26 CSGALNACT2chondroitin sulfate N-acetylgalactosaminyltransferase 2 (222235_s_at), score: -0.28 CST3cystatin C (201360_at), score: -0.27 CTSAcathepsin A (200661_at), score: -0.2 CTSL1cathepsin L1 (202087_s_at), score: -0.21 CTSOcathepsin O (203758_at), score: -0.19 CXCL3chemokine (C-X-C motif) ligand 3 (207850_at), score: -0.24 DCNdecorin (211896_s_at), score: -0.27 DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked (205000_at), score: -0.29 DESdesmin (202222_s_at), score: 1 DGKDdiacylglycerol kinase, delta 130kDa (208072_s_at), score: -0.23 DKK2dickkopf homolog 2 (Xenopus laevis) (219908_at), score: -0.48 DOCK9dedicator of cytokinesis 9 (212538_at), score: -0.21 DPP4dipeptidyl-peptidase 4 (211478_s_at), score: -0.36 DPTdermatopontin (213068_at), score: -0.25 DUSP14dual specificity phosphatase 14 (203367_at), score: -0.2 ECM1extracellular matrix protein 1 (209365_s_at), score: -0.37 EDN1endothelin 1 (218995_s_at), score: -0.18 EGLN2egl nine homolog 2 (C. elegans) (220956_s_at), score: 0.59 EGR2early growth response 2 (Krox-20 homolog, Drosophila) (205249_at), score: -0.21 EGR3early growth response 3 (206115_at), score: -0.28 EIF1AYeukaryotic translation initiation factor 1A, Y-linked (204409_s_at), score: -0.2 EXD3exonuclease 3'-5' domain containing 3 (220838_at), score: 0.64 F10coagulation factor X (205620_at), score: -0.31 F3coagulation factor III (thromboplastin, tissue factor) (204363_at), score: -0.34 FADS3fatty acid desaturase 3 (216080_s_at), score: -0.19 FGF2fibroblast growth factor 2 (basic) (204421_s_at), score: -0.21 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: -0.3 FHOD1formin homology 2 domain containing 1 (218530_at), score: -0.2 FNDC3Afibronectin type III domain containing 3A (202304_at), score: -0.24 FOSBFBJ murine osteosarcoma viral oncogene homolog B (202768_at), score: -0.32 GAAglucosidase, alpha; acid (202812_at), score: -0.23 GAP43growth associated protein 43 (204471_at), score: 0.8 GDF11growth differentiation factor 11 (216860_s_at), score: 0.59 GEMGTP binding protein overexpressed in skeletal muscle (204472_at), score: -0.25 GNALguanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type (206355_at), score: 0.62 GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (212959_s_at), score: -0.22 GPLD1glycosylphosphatidylinositol specific phospholipase D1 (206264_at), score: 0.6 GPNMBglycoprotein (transmembrane) nmb (201141_at), score: -0.65 GPR37G protein-coupled receptor 37 (endothelin receptor type B-like) (209631_s_at), score: -0.21 GPX3glutathione peroxidase 3 (plasma) (214091_s_at), score: -0.21 GRAMD3GRAM domain containing 3 (218706_s_at), score: -0.19 GRNgranulin (211284_s_at), score: -0.31 GSTT1glutathione S-transferase theta 1 (203815_at), score: -0.18 HBEGFheparin-binding EGF-like growth factor (203821_at), score: -0.28 HHEXhematopoietically expressed homeobox (215933_s_at), score: -0.2 HIST1H4Ehistone cluster 1, H4e (206951_at), score: 0.62 HK2hexokinase 2 (202934_at), score: -0.4 HLA-Amajor histocompatibility complex, class I, A (217436_x_at), score: -0.3 HLA-Bmajor histocompatibility complex, class I, B (211911_x_at), score: -0.31 HLA-Cmajor histocompatibility complex, class I, C (211799_x_at), score: -0.39 HLA-Emajor histocompatibility complex, class I, E (200904_at), score: -0.42 HLA-Fmajor histocompatibility complex, class I, F (204806_x_at), score: -0.35 HMGN1high-mobility group nucleosome binding domain 1 (200944_s_at), score: 0.62 HMOX1heme oxygenase (decycling) 1 (203665_at), score: -0.32 HOXB6homeobox B6 (205366_s_at), score: -0.21 HOXB7homeobox B7 (204779_s_at), score: -0.18 HOXC10homeobox C10 (218959_at), score: -0.24 HPCAL1hippocalcin-like 1 (205462_s_at), score: -0.29 HSD17B11hydroxysteroid (17-beta) dehydrogenase 11 (217989_at), score: -0.21 HSPB7heat shock 27kDa protein family, member 7 (cardiovascular) (218934_s_at), score: -0.29 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (207135_at), score: -0.24 HTR2B5-hydroxytryptamine (serotonin) receptor 2B (206638_at), score: -0.21 HTRA1HtrA serine peptidase 1 (201185_at), score: -0.25 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: -0.21 IDI1isopentenyl-diphosphate delta isomerase 1 (204615_x_at), score: -0.25 IDUAiduronidase, alpha-L- (205059_s_at), score: -0.2 IFITM1interferon induced transmembrane protein 1 (9-27) (214022_s_at), score: -0.32 IL11interleukin 11 (206924_at), score: -0.18 IL1RAPinterleukin 1 receptor accessory protein (205227_at), score: -0.27 IL1RL1interleukin 1 receptor-like 1 (207526_s_at), score: -0.48 IL6interleukin 6 (interferon, beta 2) (205207_at), score: -0.47 IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor) (204864_s_at), score: -0.18 IL8interleukin 8 (202859_x_at), score: -0.32 ITIH2inter-alpha (globulin) inhibitor H2 (204987_at), score: 0.66 ITPR3inositol 1,4,5-triphosphate receptor, type 3 (201189_s_at), score: -0.27 JARID2jumonji, AT rich interactive domain 2 (203297_s_at), score: -0.27 JHDM1Djumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (221778_at), score: -0.28 JMJD3jumonji domain containing 3, histone lysine demethylase (213146_at), score: -0.33 KANK1KN motif and ankyrin repeat domains 1 (213005_s_at), score: -0.19 KCNN4potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (204401_at), score: -0.18 KHDRBS3KH domain containing, RNA binding, signal transduction associated 3 (209781_s_at), score: -0.28 KIAA0247KIAA0247 (202181_at), score: -0.19 KIAA1644KIAA1644 (52837_at), score: -0.29 KLHL21kelch-like 21 (Drosophila) (203068_at), score: -0.22 KLHL26kelch-like 26 (Drosophila) (219354_at), score: -0.18 LEPROTleptin receptor overlapping transcript (202378_s_at), score: -0.21 LGALS3BPlectin, galactoside-binding, soluble, 3 binding protein (200923_at), score: -0.19 LGR4leucine-rich repeat-containing G protein-coupled receptor 4 (218326_s_at), score: 0.64 LHFPlipoma HMGIC fusion partner (218656_s_at), score: -0.39 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: -0.2 LMBRD1LMBR1 domain containing 1 (218191_s_at), score: -0.36 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: -0.31 LOC100128809similar to hCG2045829 (215707_s_at), score: -0.18 LOC286434hypothetical protein LOC286434 (222196_at), score: 0.64 LOC730227hypothetical protein LOC730227 (215756_at), score: 0.59 LRIG1leucine-rich repeats and immunoglobulin-like domains 1 (211596_s_at), score: -0.2 LRRC15leucine rich repeat containing 15 (213909_at), score: -0.24 LY96lymphocyte antigen 96 (206584_at), score: -0.36 MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) (209348_s_at), score: -0.18 MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2 (209737_at), score: -0.21 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: -0.31 MAN2B1mannosidase, alpha, class 2B, member 1 (209166_s_at), score: -0.32 MAN2B2mannosidase, alpha, class 2B, member 2 (214703_s_at), score: -0.2 MEIS1Meis homeobox 1 (204069_at), score: -0.21 MEIS3P1Meis homeobox 3 pseudogene 1 (214077_x_at), score: -0.27 MEOX1mesenchyme homeobox 1 (205619_s_at), score: 0.65 MFAP4microfibrillar-associated protein 4 (212713_at), score: -0.29 MKS1Meckel syndrome, type 1 (218630_at), score: 0.6 MTSS1metastasis suppressor 1 (203037_s_at), score: -0.26 MUC3Amucin 3A, cell surface associated (217117_x_at), score: 0.6 MYO1Dmyosin ID (212338_at), score: -0.36 NAMPTnicotinamide phosphoribosyltransferase (217738_at), score: -0.36 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: -0.36 NFIL3nuclear factor, interleukin 3 regulated (203574_at), score: -0.3 NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: -0.38 NID1nidogen 1 (202008_s_at), score: -0.25 NINJ1ninjurin 1 (203045_at), score: -0.27 NKX3-1NK3 homeobox 1 (209706_at), score: -0.18 NLGN4Xneuroligin 4, X-linked (221933_at), score: 0.71 NOVA1neuro-oncological ventral antigen 1 (205794_s_at), score: 0.62 NPnucleoside phosphorylase (201695_s_at), score: -0.21 NPC1Niemann-Pick disease, type C1 (202679_at), score: -0.3 NPC2Niemann-Pick disease, type C2 (200701_at), score: -0.43 NPTX1neuronal pentraxin I (204684_at), score: -0.21 NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (201866_s_at), score: -0.19 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: -0.37 NT5DC25'-nucleotidase domain containing 2 (218051_s_at), score: 0.62 OLFML2Aolfactomedin-like 2A (213075_at), score: -0.28 OSTM1osteopetrosis associated transmembrane protein 1 (218196_at), score: -0.25 PDGFAplatelet-derived growth factor alpha polypeptide (205463_s_at), score: -0.25 PDGFDplatelet derived growth factor D (219304_s_at), score: -0.3 PIAS4protein inhibitor of activated STAT, 4 (212881_at), score: 0.59 PIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide (203879_at), score: -0.3 PKP2plakophilin 2 (207717_s_at), score: -0.26 PLAURplasminogen activator, urokinase receptor (211924_s_at), score: -0.18 PLSCR4phospholipid scramblase 4 (218901_at), score: -0.22 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: -0.4 PPAP2Aphosphatidic acid phosphatase type 2A (209147_s_at), score: -0.3 PPARDperoxisome proliferator-activated receptor delta (37152_at), score: -0.37 PPLperiplakin (203407_at), score: -0.25 PSG4pregnancy specific beta-1-glycoprotein 4 (208191_x_at), score: -0.19 PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (209040_s_at), score: -0.21 PTGDSprostaglandin D2 synthase 21kDa (brain) (212187_x_at), score: -0.34 PTNpleiotrophin (209466_x_at), score: -0.19 RAPGEF2Rap guanine nucleotide exchange factor (GEF) 2 (203097_s_at), score: -0.32 RCAN2regulator of calcineurin 2 (203498_at), score: -0.4 RCL1RNA terminal phosphate cyclase-like 1 (218544_s_at), score: -0.2 RGS2regulator of G-protein signaling 2, 24kDa (202388_at), score: -0.18 RGS3regulator of G-protein signaling 3 (203823_at), score: -0.36 RPL7P24ribosomal protein L7 pseudogene 24 (217092_x_at), score: 0.62 RPS4Y1ribosomal protein S4, Y-linked 1 (201909_at), score: -0.37 RRADRas-related associated with diabetes (204803_s_at), score: -0.48 RUNX1runt-related transcription factor 1 (209360_s_at), score: -0.26 SAT1spermidine/spermine N1-acetyltransferase 1 (213988_s_at), score: -0.21 SCARB2scavenger receptor class B, member 2 (201647_s_at), score: -0.19 SCPEP1serine carboxypeptidase 1 (218217_at), score: -0.26 SECTM1secreted and transmembrane 1 (213716_s_at), score: -0.26 SEMA4Gsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G (219194_at), score: 0.6 SEMA5Asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A (205405_at), score: -0.19 SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 2 (204614_at), score: -0.25 SETD3SET domain containing 3 (212465_at), score: -0.21 SFRS5splicing factor, arginine/serine-rich 5 (212266_s_at), score: -0.22 SGSHN-sulfoglucosamine sulfohydrolase (35626_at), score: -0.19 SHBSrc homology 2 domain containing adaptor protein B (204657_s_at), score: -0.24 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: -0.24 SLC2A10solute carrier family 2 (facilitated glucose transporter), member 10 (221024_s_at), score: -0.19 SLC39A8solute carrier family 39 (zinc transporter), member 8 (209267_s_at), score: -0.27 SLCO3A1solute carrier organic anion transporter family, member 3A1 (219229_at), score: -0.21 SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 (201074_at), score: 0.6 SMOXspermine oxidase (210357_s_at), score: -0.2 SOCS2suppressor of cytokine signaling 2 (203373_at), score: -0.22 SOD2superoxide dismutase 2, mitochondrial (221477_s_at), score: -0.21 SOD3superoxide dismutase 3, extracellular (205236_x_at), score: -0.31 SOX11SRY (sex determining region Y)-box 11 (204914_s_at), score: 0.68 SOX4SRY (sex determining region Y)-box 4 (201417_at), score: -0.21 SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: -0.23 SPRY2sprouty homolog 2 (Drosophila) (204011_at), score: -0.22 SPRY4sprouty homolog 4 (Drosophila) (221489_s_at), score: -0.27 SQRDLsulfide quinone reductase-like (yeast) (217995_at), score: -0.24 STK38Lserine/threonine kinase 38 like (212572_at), score: -0.24 STOMstomatin (201060_x_at), score: -0.24 STXBP5Lsyntaxin binding protein 5-like (215518_at), score: 0.59 SULF1sulfatase 1 (212353_at), score: -0.21 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: -0.33 TBX3T-box 3 (219682_s_at), score: -0.29 TCOF1Treacher Collins-Franceschetti syndrome 1 (202385_s_at), score: 0.6 TEX2testis expressed 2 (218099_at), score: -0.24 THBDthrombomodulin (203887_s_at), score: -0.3 TM2D1TM2 domain containing 1 (211703_s_at), score: -0.37 TM6SF1transmembrane 6 superfamily member 1 (219892_at), score: -0.2 TMBIM4transmembrane BAX inhibitor motif containing 4 (219206_x_at), score: -0.24 TMEM158transmembrane protein 158 (213338_at), score: -0.22 TMEM41Btransmembrane protein 41B (212623_at), score: -0.4 TNFAIP2tumor necrosis factor, alpha-induced protein 2 (202510_s_at), score: -0.35 TNFAIP8tumor necrosis factor, alpha-induced protein 8 (210260_s_at), score: -0.2 TNFRSF11Btumor necrosis factor receptor superfamily, member 11b (204933_s_at), score: -0.34 TNFRSF1Btumor necrosis factor receptor superfamily, member 1B (203508_at), score: -0.19 TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (207426_s_at), score: -0.25 TNS3tensin 3 (217853_at), score: -0.28 TNXBtenascin XB (216333_x_at), score: -0.2 TOM1target of myb1 (chicken) (202807_s_at), score: -0.19 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: -0.24 TP53I11tumor protein p53 inducible protein 11 (214667_s_at), score: -0.21 TPP1tripeptidyl peptidase I (200742_s_at), score: -0.4 TPST1tyrosylprotein sulfotransferase 1 (204140_at), score: -0.29 TPST2tyrosylprotein sulfotransferase 2 (204079_at), score: -0.18 TRAF3TNF receptor-associated factor 3 (221571_at), score: -0.2 TRAF3IP2TRAF3 interacting protein 2 (215411_s_at), score: -0.25 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: -0.3 TRIM22tripartite motif-containing 22 (213293_s_at), score: -0.26 USP22ubiquitin specific peptidase 22 (200083_at), score: 0.64 VEGFAvascular endothelial growth factor A (211527_x_at), score: -0.25 WISP2WNT1 inducible signaling pathway protein 2 (205792_at), score: -0.4 WTAPWilms tumor 1 associated protein (210285_x_at), score: -0.32 YRDCyrdC domain containing (E. coli) (218647_s_at), score: -0.2 ZBTB20zinc finger and BTB domain containing 20 (205383_s_at), score: -0.2 ZKSCAN3zinc finger with KRAB and SCAN domains 3 (211773_s_at), score: 0.62 ZMYM6zinc finger, MYM-type 6 (219924_s_at), score: -0.23 ZNF35zinc finger protein 35 (206096_at), score: -0.19 ZNF672zinc finger protein 672 (218068_s_at), score: -0.2

Non-Entrez genes

Unknown, score:

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Id sample Experiment ExpName Array Syndrome Cell.line
t21b 08-03.CEL 5 1 DS-CC hgu133a Down DS-CC 5
t21d 08-03.CEL 7 1 DS-CC hgu133a Down DS-CC 7
t21c 08-03.CEL 6 1 DS-CC hgu133a Down DS-CC 6
5CTwin.CEL 5 2 DS-twin hgu133plus2 Down DS-twin 5
2Twin.CEL 2 2 DS-twin hgu133plus2 none DS-twin 2
6Twin.CEL 6 2 DS-twin hgu133plus2 none DS-twin 6
1Twin.CEL 1 2 DS-twin hgu133plus2 Down DS-twin 1

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