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Expression data for module #956

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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skeletal system development

The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

blood vessel development

The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone.

cell activation

A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

regulation of protein amino acid phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

vasculature development

The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

immune system development

The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

apoptosis

A form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. Apoptosis is usually induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

cellular alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

transcription

The synthesis of either RNA on a template of DNA or DNA on a template of RNA.

transcription, DNA-dependent

The synthesis of RNA on a template of DNA.

regulation of transcription, DNA-dependent

Any process that modulates the frequency, rate or extent of DNA-dependent transcription.

regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

transcription from RNA polymerase II promoter

The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

protein amino acid phosphorylation

The process of introducing a phosphate group on to a protein.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

phosphorus metabolic process

The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).

phosphate metabolic process

The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism.

cell motion

Any process involved in the controlled movement of a cell.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

cell surface receptor linked signal transduction

Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.

cell-cell signaling

Any process that mediates the transfer of information from one cell to another.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

behavior

The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cell death

The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

programmed cell death

Cell death resulting from activation of endogenous cellular processes.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

negative regulation of cell proliferation

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

regulation of biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

gene expression

The process by which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

positive regulation of phosphorus metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

RNA metabolic process

The chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

death

A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.

phosphorylation

The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

regulation of apoptosis

Any process that modulates the occurrence or rate of cell death by apoptosis.

cell migration

The orderly movement of cells from one site to another, often during the development of a multicellular organism or multicellular structure.

regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

regulation of phosphate metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

regulation of anatomical structure morphogenesis

Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.

respiratory tube development

The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.

lung development

The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

regulation of protein modification process

Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

RNA biosynthetic process

The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

tube development

The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.

locomotion

Self-propelled movement of a cell or organism from one location to another.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

regulation of phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

negative regulation of apoptosis

Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis.

regulation of programmed cell death

Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

negative regulation of programmed cell death

Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

biopolymer modification

The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer, resulting in a change in its properties.

post-translational protein modification

The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

leukocyte activation

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.

regulation of transcription

Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

regulation of angiogenesis

Any process that modulates the frequency, rate or extent of angiogenesis.

positive regulation of angiogenesis

Any process that activates or increases angiogenesis.

positive regulation of phosphate metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

hemopoietic or lymphoid organ development

The process whose specific outcome is the progression of any organ involved in hemopoiesis or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of developmental process

Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

regulation of secretion

Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or group of cells.

regulation of transport

Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

negative regulation of developmental process

Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of phosphorus metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

regulation of RNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

localization of cell

Any process by which a cell is transported to, and/or maintained in, a specific location.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

all

This term is the most general term possible

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

negative regulation of developmental process

Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of developmental process

Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

leukocyte activation

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

negative regulation of cell proliferation

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cell death

The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

tube development

The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

regulation of anatomical structure morphogenesis

Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.

regulation of programmed cell death

Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

negative regulation of developmental process

Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

negative regulation of programmed cell death

Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

cell motion

Any process involved in the controlled movement of a cell.

regulation of transport

Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

transcription

The synthesis of either RNA on a template of DNA or DNA on a template of RNA.

regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

positive regulation of phosphorus metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

regulation of phosphorus metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

regulation of programmed cell death

Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

negative regulation of programmed cell death

Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

negative regulation of cell proliferation

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

negative regulation of programmed cell death

Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

immune system development

The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

positive regulation of angiogenesis

Any process that activates or increases angiogenesis.

regulation of angiogenesis

Any process that modulates the frequency, rate or extent of angiogenesis.

regulation of angiogenesis

Any process that modulates the frequency, rate or extent of angiogenesis.

positive regulation of angiogenesis

Any process that activates or increases angiogenesis.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

respiratory tube development

The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.

hemopoietic or lymphoid organ development

The process whose specific outcome is the progression of any organ involved in hemopoiesis or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.

ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

regulation of secretion

Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or group of cells.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

regulation of transcription

Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

regulation of transcription

Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

regulation of RNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.

positive regulation of phosphorus metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

regulation of transcription

Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

transcription, DNA-dependent

The synthesis of RNA on a template of DNA.

regulation of transcription

Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.

RNA metabolic process

The chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

RNA biosynthetic process

The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.

regulation of RNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.

regulation of phosphate metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

positive regulation of phosphate metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

regulation of apoptosis

Any process that modulates the occurrence or rate of cell death by apoptosis.

negative regulation of apoptosis

Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis.

negative regulation of apoptosis

Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis.

lung development

The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.

bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

regulation of transcription, DNA-dependent

Any process that modulates the frequency, rate or extent of DNA-dependent transcription.

transcription

The synthesis of either RNA on a template of DNA or DNA on a template of RNA.

regulation of transcription, DNA-dependent

Any process that modulates the frequency, rate or extent of DNA-dependent transcription.

positive regulation of phosphate metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

regulation of protein modification process

Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

regulation of phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

regulation of protein amino acid phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

protein amino acid phosphorylation

The process of introducing a phosphate group on to a protein.

regulation of protein amino acid phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

Help | Hide | Top The GO tree — Cellular Components

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extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

proteinaceous extracellular matrix

A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

extracellular matrix

A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants).

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

all

This term is the most general term possible

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

Help | Hide | Top The GO tree — Molecular Function

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protein binding

Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

G-protein-coupled receptor binding

Interacting selectively with a G-protein-coupled receptor.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

nucleic acid binding

Interacting selectively with any nucleic acid.

DNA binding

Interacting selectively with DNA (deoxyribonucleic acid).

transcription factor activity

The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

receptor binding

Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

chemokine activity

The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

transcription repressor activity

Any transcription regulator activity that prevents or downregulates transcription.

transcription regulator activity

Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor.

chemokine receptor binding

Interacting selectively with any chemokine receptor.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

This term is the most general term possible

transcription factor activity

The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.

chemokine activity

The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04060 2.017e-07 6.713 26
122 Cytokine-cytokine receptor interaction
04010 2.759e-04 10.23 27
186 MAPK signaling pathway

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ABCA1ATP-binding cassette, sub-family A (ABC1), member 1 (203504_s_at), score: -0.19 ABCA5ATP-binding cassette, sub-family A (ABC1), member 5 (213353_at), score: -0.34 ABHD10abhydrolase domain containing 10 (218633_x_at), score: 0.75 ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 5 (219935_at), score: -0.31 ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide (209612_s_at), score: -0.6 ADIPOR2adiponectin receptor 2 (201346_at), score: -0.22 ADRA2Aadrenergic, alpha-2A-, receptor (209869_at), score: -0.45 AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (209160_at), score: -0.29 ALDH6A1aldehyde dehydrogenase 6 family, member A1 (221589_s_at), score: -0.23 ANGangiogenin, ribonuclease, RNase A family, 5 (213397_x_at), score: -0.23 ANGPTL2angiopoietin-like 2 (213001_at), score: -0.34 ANGPTL4angiopoietin-like 4 (221009_s_at), score: -0.79 ANK2ankyrin 2, neuronal (202920_at), score: -0.4 APODapolipoprotein D (201525_at), score: -0.4 AQP1aquaporin 1 (Colton blood group) (209047_at), score: -0.22 AQP3aquaporin 3 (Gill blood group) (39248_at), score: -0.35 AREGamphiregulin (205239_at), score: -0.28 ARHGAP5Rho GTPase activating protein 5 (217936_at), score: -0.24 ARID5AAT rich interactive domain 5A (MRF1-like) (213138_at), score: -0.25 ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (206414_s_at), score: -0.22 ATF3activating transcription factor 3 (202672_s_at), score: -0.33 ATP13A3ATPase type 13A3 (219558_at), score: -0.4 B3GNT2UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (219326_s_at), score: -0.51 BCL6B-cell CLL/lymphoma 6 (203140_at), score: -0.2 BCL7AB-cell CLL/lymphoma 7A (203795_s_at), score: -0.21 BHLHE40basic helix-loop-helix family, member e40 (201170_s_at), score: -0.45 BIRC3baculoviral IAP repeat-containing 3 (210538_s_at), score: -0.19 BMP2bone morphogenetic protein 2 (205289_at), score: -0.62 BMP6bone morphogenetic protein 6 (206176_at), score: -0.36 BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase) (210214_s_at), score: -0.27 BNC1basonuclin 1 (206581_at), score: -0.38 C10orf72chromosome 10 open reading frame 72 (213381_at), score: -0.21 C13orf15chromosome 13 open reading frame 15 (218723_s_at), score: -0.4 C13orf18chromosome 13 open reading frame 18 (44790_s_at), score: -0.23 C14orf118chromosome 14 open reading frame 118 (219720_s_at), score: -0.2 C16orf53chromosome 16 open reading frame 53 (218300_at), score: 0.71 C17orf91chromosome 17 open reading frame 91 (214696_at), score: -0.51 C1orf56chromosome 1 open reading frame 56 (221222_s_at), score: -0.43 C1Rcomplement component 1, r subcomponent (212067_s_at), score: -0.47 C1RLcomplement component 1, r subcomponent-like (218983_at), score: -0.24 C1Scomplement component 1, s subcomponent (208747_s_at), score: -0.32 C3orf52chromosome 3 open reading frame 52 (219474_at), score: -0.25 C4orf18chromosome 4 open reading frame 18 (219872_at), score: -0.35 C6orf145chromosome 6 open reading frame 145 (212923_s_at), score: -0.42 CADPS2Ca++-dependent secretion activator 2 (219572_at), score: -0.2 CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (211368_s_at), score: -0.21 CBFBcore-binding factor, beta subunit (206788_s_at), score: -0.2 CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b (209682_at), score: -0.33 CCL2chemokine (C-C motif) ligand 2 (216598_s_at), score: -0.48 CCL7chemokine (C-C motif) ligand 7 (208075_s_at), score: -0.54 CCNJcyclin J (219470_x_at), score: -0.28 CCRL1chemokine (C-C motif) receptor-like 1 (220351_at), score: -0.4 CD302CD302 molecule (203799_at), score: -0.43 CD83CD83 molecule (204440_at), score: -0.25 CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae) (208022_s_at), score: -0.21 CDH10cadherin 10, type 2 (T2-cadherin) (220115_s_at), score: -0.19 CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1) (209112_at), score: 0.76 CDV3CDV3 homolog (mouse) (213548_s_at), score: -0.21 CHST2carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 (203921_at), score: -0.35 CKAP2cytoskeleton associated protein 2 (218252_at), score: 0.72 CLCF1cardiotrophin-like cytokine factor 1 (219500_at), score: -0.41 CLUclusterin (208791_at), score: -0.3 COL14A1collagen, type XIV, alpha 1 (212865_s_at), score: -0.45 COL15A1collagen, type XV, alpha 1 (203477_at), score: -0.48 COL21A1collagen, type XXI, alpha 1 (208096_s_at), score: -0.2 COL8A1collagen, type VIII, alpha 1 (214587_at), score: -0.26 COPS3COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) (202078_at), score: 0.74 CORINcorin, serine peptidase (220356_at), score: -0.31 COX8Acytochrome c oxidase subunit 8A (ubiquitous) (201119_s_at), score: 0.73 CPA3carboxypeptidase A3 (mast cell) (205624_at), score: -0.32 CPZcarboxypeptidase Z (211062_s_at), score: -0.23 CREG1cellular repressor of E1A-stimulated genes 1 (201200_at), score: -0.36 CRISPLD2cysteine-rich secretory protein LCCL domain containing 2 (221541_at), score: -0.35 CScitrate synthase (208660_at), score: 0.76 CSF1colony stimulating factor 1 (macrophage) (209716_at), score: -0.24 CSRNP2cysteine-serine-rich nuclear protein 2 (221260_s_at), score: -0.23 CTSDcathepsin D (200766_at), score: -0.42 CTSFcathepsin F (203657_s_at), score: -0.44 CTSKcathepsin K (202450_s_at), score: -0.21 CTSOcathepsin O (203758_at), score: -0.23 CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (204470_at), score: -0.29 CXCL2chemokine (C-X-C motif) ligand 2 (209774_x_at), score: -0.41 CXCL3chemokine (C-X-C motif) ligand 3 (207850_at), score: -0.67 CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) (206336_at), score: -0.22 CXCR7chemokine (C-X-C motif) receptor 7 (212977_at), score: -0.51 CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1 (216607_s_at), score: -0.44 DACT1dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) (219179_at), score: -0.2 DCNdecorin (211896_s_at), score: -0.35 DCP1ADCP1 decapping enzyme homolog A (S. cerevisiae) (218508_at), score: -0.2 DHCR77-dehydrocholesterol reductase (201790_s_at), score: -0.23 DKK2dickkopf homolog 2 (Xenopus laevis) (219908_at), score: -0.79 DOCK9dedicator of cytokinesis 9 (212538_at), score: -0.28 DPP4dipeptidyl-peptidase 4 (211478_s_at), score: -0.42 DPTdermatopontin (213068_at), score: -0.44 DRAMdamage-regulated autophagy modulator (218627_at), score: -0.36 DUSP5dual specificity phosphatase 5 (209457_at), score: -0.46 DUSP8dual specificity phosphatase 8 (206374_at), score: -0.2 ECM2extracellular matrix protein 2, female organ and adipocyte specific (206101_at), score: -0.41 EGR2early growth response 2 (Krox-20 homolog, Drosophila) (205249_at), score: -0.65 EGR3early growth response 3 (206115_at), score: -0.66 EMP1epithelial membrane protein 1 (201325_s_at), score: -0.19 ENTPD7ectonucleoside triphosphate diphosphohydrolase 7 (220153_at), score: -0.37 ERAP1endoplasmic reticulum aminopeptidase 1 (214012_at), score: -0.24 EXOSC9exosome component 9 (205061_s_at), score: 0.73 F10coagulation factor X (205620_at), score: -0.35 F3coagulation factor III (thromboplastin, tissue factor) (204363_at), score: -0.46 FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (214285_at), score: -0.32 FAM108B1family with sequence similarity 108, member B1 (220285_at), score: -0.33 FAPfibroblast activation protein, alpha (209955_s_at), score: -0.38 FBLN1fibulin 1 (202995_s_at), score: -0.23 FBXW7F-box and WD repeat domain containing 7 (218751_s_at), score: -0.57 FCGRTFc fragment of IgG, receptor, transporter, alpha (218831_s_at), score: -0.36 FEM1Bfem-1 homolog b (C. elegans) (212367_at), score: -0.33 FGF1fibroblast growth factor 1 (acidic) (205117_at), score: -0.53 FGF2fibroblast growth factor 2 (basic) (204421_s_at), score: -0.35 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: -0.52 FHOD1formin homology 2 domain containing 1 (218530_at), score: -0.2 FILIP1Lfilamin A interacting protein 1-like (204135_at), score: -0.21 FOSBFBJ murine osteosarcoma viral oncogene homolog B (202768_at), score: -1 FOXO3forkhead box O3 (204132_s_at), score: -0.45 FOXO3Bforkhead box O3B pseudogene (210655_s_at), score: -0.61 FRYfurry homolog (Drosophila) (204072_s_at), score: -0.23 GAAglucosidase, alpha; acid (202812_at), score: -0.32 GABARAPL1GABA(A) receptor-associated protein like 1 (208868_s_at), score: -0.37 GABARAPL3GABA(A) receptors associated protein like 3 (pseudogene) (211458_s_at), score: -0.29 GADD45Agrowth arrest and DNA-damage-inducible, alpha (203725_at), score: -0.34 GADD45Bgrowth arrest and DNA-damage-inducible, beta (207574_s_at), score: -0.22 GALNAC4S-6STB cell RAG associated protein (203066_at), score: -0.29 GCH1GTP cyclohydrolase 1 (204224_s_at), score: -0.5 GEMGTP binding protein overexpressed in skeletal muscle (204472_at), score: -0.65 GFPT2glutamine-fructose-6-phosphate transaminase 2 (205100_at), score: -0.48 GMNNgeminin, DNA replication inhibitor (218350_s_at), score: 0.71 GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (212959_s_at), score: -0.31 GPNMBglycoprotein (transmembrane) nmb (201141_at), score: -0.52 GPR183G protein-coupled receptor 183 (205419_at), score: -0.34 GPR37G protein-coupled receptor 37 (endothelin receptor type B-like) (209631_s_at), score: -0.29 GPRC5BG protein-coupled receptor, family C, group 5, member B (203632_s_at), score: -0.21 GRIA3glutamate receptor, ionotrophic, AMPA 3 (206730_at), score: -0.24 GRNgranulin (211284_s_at), score: -0.2 GSTM1glutathione S-transferase mu 1 (204550_x_at), score: -0.26 HBEGFheparin-binding EGF-like growth factor (203821_at), score: -0.7 HIPK3homeodomain interacting protein kinase 3 (210148_at), score: -0.39 HIVEP1human immunodeficiency virus type I enhancer binding protein 1 (204512_at), score: -0.53 HIVEP2human immunodeficiency virus type I enhancer binding protein 2 (212642_s_at), score: -0.59 HK2hexokinase 2 (202934_at), score: -0.46 HLA-Cmajor histocompatibility complex, class I, C (211799_x_at), score: -0.2 HLXH2.0-like homeobox (214438_at), score: -0.52 HMGB2high-mobility group box 2 (208808_s_at), score: 0.8 HMGCS13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) (221750_at), score: -0.44 HMGN1high-mobility group nucleosome binding domain 1 (200944_s_at), score: 0.74 HMGN2high-mobility group nucleosomal binding domain 2 (208668_x_at), score: 0.8 HMOX1heme oxygenase (decycling) 1 (203665_at), score: -0.51 HOMER1homer homolog 1 (Drosophila) (213793_s_at), score: -0.25 HS3ST2heparan sulfate (glucosamine) 3-O-sulfotransferase 2 (219697_at), score: -0.21 HSPA12Aheat shock 70kDa protein 12A (214434_at), score: -0.26 HSPB3heat shock 27kDa protein 3 (206375_s_at), score: -0.23 HSPB7heat shock 27kDa protein family, member 7 (cardiovascular) (218934_s_at), score: -0.22 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (207135_at), score: -0.33 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: -0.5 IDI1isopentenyl-diphosphate delta isomerase 1 (204615_x_at), score: -0.55 IDI2isopentenyl-diphosphate delta isomerase 2 (217631_at), score: -0.31 IER3immediate early response 3 (201631_s_at), score: -0.3 IL11interleukin 11 (206924_at), score: -0.56 IL1Ainterleukin 1, alpha (210118_s_at), score: -0.31 IL1Binterleukin 1, beta (39402_at), score: -0.22 IL1R1interleukin 1 receptor, type I (202948_at), score: -0.25 IL1RAPinterleukin 1 receptor accessory protein (205227_at), score: -0.37 IL1RL1interleukin 1 receptor-like 1 (207526_s_at), score: -0.58 IL6interleukin 6 (interferon, beta 2) (205207_at), score: -0.65 IL8interleukin 8 (202859_x_at), score: -0.48 INHBAinhibin, beta A (210511_s_at), score: -0.34 INSIG1insulin induced gene 1 (201627_s_at), score: -0.69 ITGA1integrin, alpha 1 (214660_at), score: -0.34 ITIH5inter-alpha (globulin) inhibitor H5 (219064_at), score: -0.21 ITPKCinositol 1,4,5-trisphosphate 3-kinase C (213076_at), score: -0.39 JARID2jumonji, AT rich interactive domain 2 (203297_s_at), score: -0.42 JHDM1Djumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (221778_at), score: -0.75 JMJD3jumonji domain containing 3, histone lysine demethylase (213146_at), score: -0.92 JMJD6jumonji domain containing 6 (212722_s_at), score: -0.37 JUNBjun B proto-oncogene (201473_at), score: -0.36 JUNDjun D proto-oncogene (203751_x_at), score: -0.56 KCND3potassium voltage-gated channel, Shal-related subfamily, member 3 (213832_at), score: -0.19 KIAA0247KIAA0247 (202181_at), score: -0.36 KIAA1024KIAA1024 (215081_at), score: -0.53 KIAA1644KIAA1644 (52837_at), score: -0.51 KLF7Kruppel-like factor 7 (ubiquitous) (204334_at), score: -0.27 KLHL21kelch-like 21 (Drosophila) (203068_at), score: -0.36 KPNA4karyopherin alpha 4 (importin alpha 3) (209653_at), score: -0.2 LAMA2laminin, alpha 2 (213519_s_at), score: -0.27 LARP5La ribonucleoprotein domain family, member 5 (208953_at), score: -0.22 LBHlimb bud and heart development homolog (mouse) (221011_s_at), score: -0.26 LDLRlow density lipoprotein receptor (202068_s_at), score: -0.45 LHFPlipoma HMGIC fusion partner (218656_s_at), score: -0.35 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: -0.73 LIMS1LIM and senescent cell antigen-like domains 1 (207198_s_at), score: -0.26 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: -0.72 LOH3CR2Aloss of heterozygosity, 3, chromosomal region 2, gene A (220244_at), score: -0.78 LPPR4plasticity related gene 1 (213496_at), score: -0.2 LRIG1leucine-rich repeats and immunoglobulin-like domains 1 (211596_s_at), score: -0.35 LRP1low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) (200784_s_at), score: -0.37 LRRC2leucine rich repeat containing 2 (219949_at), score: -0.22 LRRC32leucine rich repeat containing 32 (203835_at), score: -0.21 LRRFIP1leucine rich repeat (in FLII) interacting protein 1 (201861_s_at), score: -0.22 LSM2LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) (209449_at), score: 0.73 MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast) (203362_s_at), score: 0.75 MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) (36711_at), score: -0.26 MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2 (209737_at), score: -0.24 MAN1A1mannosidase, alpha, class 1A, member 1 (221760_at), score: -0.31 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: -0.52 MAP2K3mitogen-activated protein kinase kinase 3 (215498_s_at), score: -0.44 MAP3K4mitogen-activated protein kinase kinase kinase 4 (216199_s_at), score: -0.35 MAP3K8mitogen-activated protein kinase kinase kinase 8 (205027_s_at), score: -0.27 MAT2Amethionine adenosyltransferase II, alpha (200769_s_at), score: -0.3 MAT2Bmethionine adenosyltransferase II, beta (217993_s_at), score: 0.71 MEIS3P1Meis homeobox 3 pseudogene 1 (214077_x_at), score: -0.22 MFAP4microfibrillar-associated protein 4 (212713_at), score: -0.57 MSCmusculin (activated B-cell factor-1) (209928_s_at), score: -0.48 MSX1msh homeobox 1 (205932_s_at), score: -0.35 MTSS1metastasis suppressor 1 (203037_s_at), score: -0.43 MXRA5matrix-remodelling associated 5 (209596_at), score: -0.21 MYCv-myc myelocytomatosis viral oncogene homolog (avian) (202431_s_at), score: -0.25 MYO1Dmyosin ID (212338_at), score: -0.44 NAB1NGFI-A binding protein 1 (EGR1 binding protein 1) (208047_s_at), score: -0.28 NAMPTnicotinamide phosphoribosyltransferase (217738_at), score: -0.45 NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 1 (208093_s_at), score: -0.21 NDRG1N-myc downstream regulated 1 (200632_s_at), score: -0.19 NEDD9neural precursor cell expressed, developmentally down-regulated 9 (202149_at), score: -0.36 NET1neuroepithelial cell transforming 1 (201830_s_at), score: -0.28 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: -0.8 NFIL3nuclear factor, interleukin 3 regulated (203574_at), score: -0.48 NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: -0.49 NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) (207535_s_at), score: -0.24 NGFnerve growth factor (beta polypeptide) (206814_at), score: -0.32 NINJ1ninjurin 1 (203045_at), score: -0.36 NKX3-1NK3 homeobox 1 (209706_at), score: -0.29 NPnucleoside phosphorylase (201695_s_at), score: -0.22 NPC1Niemann-Pick disease, type C1 (202679_at), score: -0.19 NPC2Niemann-Pick disease, type C2 (200701_at), score: -0.22 NPTX1neuronal pentraxin I (204684_at), score: -0.21 NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (201866_s_at), score: -0.44 NR4A1nuclear receptor subfamily 4, group A, member 1 (202340_x_at), score: -0.55 NR4A2nuclear receptor subfamily 4, group A, member 2 (216248_s_at), score: -0.48 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: -0.84 NSMCE4Anon-SMC element 4 homolog A (S. cerevisiae) (219067_s_at), score: 0.71 NUCKS1nuclear casein kinase and cyclin-dependent kinase substrate 1 (217802_s_at), score: 0.72 NUP93nucleoporin 93kDa (202188_at), score: 0.75 NUPL1nucleoporin like 1 (204435_at), score: -0.27 OLFML2Aolfactomedin-like 2A (213075_at), score: -0.25 OMDosteomodulin (205907_s_at), score: -0.23 OR1E2olfactory receptor, family 1, subfamily E, member 2 (208587_s_at), score: -0.29 OSMRoncostatin M receptor (205729_at), score: -0.23 PANX1pannexin 1 (204715_at), score: -0.23 PARP2poly (ADP-ribose) polymerase 2 (214086_s_at), score: 0.73 PCTK2PCTAIRE protein kinase 2 (221918_at), score: -0.19 PDGFAplatelet-derived growth factor alpha polypeptide (205463_s_at), score: -0.49 PDGFDplatelet derived growth factor D (219304_s_at), score: -0.6 PDGFRBplatelet-derived growth factor receptor, beta polypeptide (202273_at), score: -0.32 PDGFRLplatelet-derived growth factor receptor-like (205226_at), score: -0.41 PELI1pellino homolog 1 (Drosophila) (218319_at), score: -0.26 PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (202464_s_at), score: -0.32 PIGBphosphatidylinositol glycan anchor biosynthesis, class B (214151_s_at), score: -0.19 PIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide (203879_at), score: -0.5 PLAURplasminogen activator, urokinase receptor (211924_s_at), score: -0.35 PLK3polo-like kinase 3 (Drosophila) (204958_at), score: -0.29 PLSCR4phospholipid scramblase 4 (218901_at), score: -0.42 PLXNC1plexin C1 (213241_at), score: -0.21 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: -0.79 POLR1Cpolymerase (RNA) I polypeptide C, 30kDa (207515_s_at), score: -0.29 PPAP2Aphosphatidic acid phosphatase type 2A (209147_s_at), score: -0.3 PPARDperoxisome proliferator-activated receptor delta (37152_at), score: -0.29 PPLperiplakin (203407_at), score: -0.61 PRELPproline/arginine-rich end leucine-rich repeat protein (204223_at), score: -0.3 PRKG1protein kinase, cGMP-dependent, type I (207119_at), score: -0.35 PROS1protein S (alpha) (207808_s_at), score: -0.3 PSAPprosaposin (200866_s_at), score: -0.25 PSG4pregnancy specific beta-1-glycoprotein 4 (208191_x_at), score: -0.27 PTGDSprostaglandin D2 synthase 21kDa (brain) (212187_x_at), score: -0.27 PTGESprostaglandin E synthase (210367_s_at), score: -0.2 PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (204748_at), score: -0.25 PTHLHparathyroid hormone-like hormone (211756_at), score: -0.41 PTPREprotein tyrosine phosphatase, receptor type, E (221840_at), score: -0.45 RABGEF1RAB guanine nucleotide exchange factor (GEF) 1 (218310_at), score: -0.23 RANBP2RAN binding protein 2 (201711_x_at), score: -0.36 RAPGEF2Rap guanine nucleotide exchange factor (GEF) 2 (203097_s_at), score: -0.24 RASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated) (205590_at), score: -0.22 RASSF8Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 (207754_at), score: -0.34 RBMS1RNA binding motif, single stranded interacting protein 1 (209868_s_at), score: -0.21 RCAN2regulator of calcineurin 2 (203498_at), score: -0.5 RCL1RNA terminal phosphate cyclase-like 1 (218544_s_at), score: -0.34 RELv-rel reticuloendotheliosis viral oncogene homolog (avian) (206036_s_at), score: -0.45 RELBv-rel reticuloendotheliosis viral oncogene homolog B (205205_at), score: -0.39 RFC4replication factor C (activator 1) 4, 37kDa (204023_at), score: 0.75 RFC5replication factor C (activator 1) 5, 36.5kDa (213734_at), score: 0.73 RGPD5RANBP2-like and GRIP domain containing 5 (210676_x_at), score: -0.28 RGS2regulator of G-protein signaling 2, 24kDa (202388_at), score: -0.42 RGS3regulator of G-protein signaling 3 (203823_at), score: -0.39 RNASE4ribonuclease, RNase A family, 4 (205158_at), score: -0.26 RNF103ring finger protein 103 (202636_at), score: -0.25 RPP30ribonuclease P/MRP 30kDa subunit (203436_at), score: 0.77 RRADRas-related associated with diabetes (204803_s_at), score: -0.83 RUNX1runt-related transcription factor 1 (209360_s_at), score: -0.49 RYBPRING1 and YY1 binding protein (201846_s_at), score: -0.27 SAE1SUMO1 activating enzyme subunit 1 (217946_s_at), score: 0.71 SALL1sal-like 1 (Drosophila) (206893_at), score: -0.29 SC4MOLsterol-C4-methyl oxidase-like (209146_at), score: -0.33 SCDstearoyl-CoA desaturase (delta-9-desaturase) (200832_s_at), score: -0.27 SECTM1secreted and transmembrane 1 (213716_s_at), score: -0.21 SEPP1selenoprotein P, plasma, 1 (201427_s_at), score: -0.26 SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 2 (204614_at), score: -0.32 SERPINF1serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (202283_at), score: -0.23 SFRS5splicing factor, arginine/serine-rich 5 (212266_s_at), score: -0.22 SGK1serum/glucocorticoid regulated kinase 1 (201739_at), score: -0.41 SHBSrc homology 2 domain containing adaptor protein B (204657_s_at), score: -0.43 SIRPAsignal-regulatory protein alpha (202897_at), score: -0.2 SKILSKI-like oncogene (206675_s_at), score: -0.55 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: -0.64 SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3 (202800_at), score: -0.22 SLC2A14solute carrier family 2 (facilitated glucose transporter), member 14 (222088_s_at), score: -0.28 SLC2A3P1solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 1 (221751_at), score: -0.26 SLC38A2solute carrier family 38, member 2 (220924_s_at), score: 0.72 SLC39A8solute carrier family 39 (zinc transporter), member 8 (209267_s_at), score: -0.29 SLC46A3solute carrier family 46, member 3 (214719_at), score: -0.25 SLIT3slit homolog 3 (Drosophila) (203813_s_at), score: -0.24 SMAD7SMAD family member 7 (204790_at), score: -0.24 SMOXspermine oxidase (210357_s_at), score: -0.67 SOD2superoxide dismutase 2, mitochondrial (221477_s_at), score: -0.39 SOX4SRY (sex determining region Y)-box 4 (201417_at), score: -0.44 SOX9SRY (sex determining region Y)-box 9 (202935_s_at), score: -0.5 SPATA2Lspermatogenesis associated 2-like (214965_at), score: -0.41 SPHK1sphingosine kinase 1 (219257_s_at), score: -0.28 SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: -0.59 SPRY2sprouty homolog 2 (Drosophila) (204011_at), score: -0.55 SPRY4sprouty homolog 4 (Drosophila) (221489_s_at), score: -0.54 SPSB1splA/ryanodine receptor domain and SOCS box containing 1 (219677_at), score: -0.58 SQLEsqualene epoxidase (213562_s_at), score: -0.51 SREBF2sterol regulatory element binding transcription factor 2 (201247_at), score: -0.21 SRFserum response factor (c-fos serum response element-binding transcription factor) (202401_s_at), score: -0.55 ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (208322_s_at), score: -0.55 STBD1starch binding domain 1 (203986_at), score: -0.25 STK38Lserine/threonine kinase 38 like (212572_at), score: -0.57 STMN1stathmin 1/oncoprotein 18 (200783_s_at), score: 0.75 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: -0.45 TACSTD2tumor-associated calcium signal transducer 2 (202286_s_at), score: -0.26 TBX3T-box 3 (219682_s_at), score: -0.5 TGFBR1transforming growth factor, beta receptor 1 (206943_at), score: -0.56 THBDthrombomodulin (203887_s_at), score: -0.74 TICAM1toll-like receptor adaptor molecule 1 (213191_at), score: -0.28 TM6SF1transmembrane 6 superfamily member 1 (219892_at), score: -0.27 TMEM39Atransmembrane protein 39A (218615_s_at), score: -0.2 TMEM41Btransmembrane protein 41B (212623_at), score: -0.5 TNFAIP2tumor necrosis factor, alpha-induced protein 2 (202510_s_at), score: -0.34 TNFAIP3tumor necrosis factor, alpha-induced protein 3 (202644_s_at), score: -0.36 TNFAIP6tumor necrosis factor, alpha-induced protein 6 (206026_s_at), score: -0.32 TNFAIP8tumor necrosis factor, alpha-induced protein 8 (210260_s_at), score: -0.39 TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (207426_s_at), score: -0.29 TNFSF9tumor necrosis factor (ligand) superfamily, member 9 (206907_at), score: -0.29 TNS3tensin 3 (217853_at), score: -0.34 TNXAtenascin XA pseudogene (213451_x_at), score: -0.34 TNXBtenascin XB (216333_x_at), score: -0.39 TOM1target of myb1 (chicken) (202807_s_at), score: -0.22 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: -0.35 TP53I11tumor protein p53 inducible protein 11 (214667_s_at), score: -0.3 TPP1tripeptidyl peptidase I (200742_s_at), score: -0.32 TPST1tyrosylprotein sulfotransferase 1 (204140_at), score: -0.28 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: -0.66 TRIM22tripartite motif-containing 22 (213293_s_at), score: -0.24 TRMT5TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae) (221952_x_at), score: 0.83 TTC17tetratricopeptide repeat domain 17 (218972_at), score: -0.24 URB2URB2 ribosome biogenesis 2 homolog (S. cerevisiae) (205284_at), score: -0.3 USP12ubiquitin specific peptidase 12 (213327_s_at), score: -0.35 USP36ubiquitin specific peptidase 36 (220370_s_at), score: -0.2 UTP3UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) (209486_at), score: -0.24 VCLvinculin (200930_s_at), score: -0.33 VDRvitamin D (1,25- dihydroxyvitamin D3) receptor (204255_s_at), score: -0.44 VEGFAvascular endothelial growth factor A (211527_x_at), score: -0.71 VPS37Bvacuolar protein sorting 37 homolog B (S. cerevisiae) (221704_s_at), score: -0.25 WEE1WEE1 homolog (S. pombe) (212533_at), score: 0.77 WISP1WNT1 inducible signaling pathway protein 1 (206796_at), score: -0.45 WISP2WNT1 inducible signaling pathway protein 2 (205792_at), score: -0.51 WNT2wingless-type MMTV integration site family member 2 (205648_at), score: -0.29 WTAPWilms tumor 1 associated protein (210285_x_at), score: -0.31 WWTR1WW domain containing transcription regulator 1 (202132_at), score: -0.19 XPO1exportin 1 (CRM1 homolog, yeast) (208775_at), score: 0.74 YOD1YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) (215150_at), score: -0.24 YRDCyrdC domain containing (E. coli) (218647_s_at), score: -0.35 ZC3H4zinc finger CCCH-type containing 4 (213390_at), score: 0.78 ZCCHC2zinc finger, CCHC domain containing 2 (219062_s_at), score: -0.23 ZFP36L1zinc finger protein 36, C3H type-like 1 (211965_at), score: -0.26 ZFYzinc finger protein, Y-linked (207246_at), score: -0.2 ZMPSTE24zinc metallopeptidase (STE24 homolog, S. cerevisiae) (202939_at), score: 0.76 ZNF143zinc finger protein 143 (221873_at), score: -0.3 ZNF282zinc finger protein 282 (212892_at), score: -0.25 ZNF35zinc finger protein 35 (206096_at), score: -0.44 ZNF672zinc finger protein 672 (218068_s_at), score: -0.29

Non-Entrez genes

Unknown, score:

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Id sample Experiment ExpName Array Syndrome Cell.line
E-TABM-263-raw-cel-1515486231.cel 30 6 Cycle hgu133a2 none Cycle 1
E-TABM-263-raw-cel-1515485851.cel 11 6 Cycle hgu133a2 none Cycle 1
ctrl b 08-03.CEL 2 1 DS-CC hgu133a none DS-CC 2
ctrl a 08-03.CEL 1 1 DS-CC hgu133a none DS-CC 1
E-TABM-263-raw-cel-1515486331.cel 35 6 Cycle hgu133a2 none Cycle 1
6Twin.CEL 6 2 DS-twin hgu133plus2 none DS-twin 6
5CTwin.CEL 5 2 DS-twin hgu133plus2 Down DS-twin 5
1Twin.CEL 1 2 DS-twin hgu133plus2 Down DS-twin 1

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