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angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

blood vessel development

The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

vasculature development

The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure.

immune effector process

Any process of the immune system that occurs as part of an immune response.

activation of immune response

Any process that initiates an immune response.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

antigen processing and presentation of peptide antigen via MHC class I

The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

activation of plasma proteins during acute inflammatory response

Any process activating plasma proteins via proteolysis during an acute inflammatory response.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

proteolysis

The hydrolysis of a peptide bond or bonds within a protein.

cell motion

Any process involved in the controlled movement of a cell.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

humoral immune response

An immune response mediated through a body fluid.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

cell surface receptor linked signal transduction

Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.

G-protein coupled receptor protein signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.

intracellular signaling cascade

A series of reactions within the cell that occur as a result of a single trigger reaction or compound.

protein kinase cascade

A series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

behavior

The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of protein kinase cascade

Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of cell communication

Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of protein kinase cascade

Any process that increases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

cell migration

The orderly movement of cells from one site to another, often during the development of a multicellular organism or multicellular structure.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

antigen processing and presentation

The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

biological adhesion

The attachment of a cell or organism to a substrate or other organism.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

locomotion

Self-propelled movement of a cell or organism from one location to another.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

antigen processing and presentation of peptide antigen

The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

localization of cell

Any process by which a cell is transported to, and/or maintained in, a specific location.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

all

This term is the most general term possible

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

immune effector process

Any process of the immune system that occurs as part of an immune response.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

positive regulation of cell communication

Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

cell motion

Any process involved in the controlled movement of a cell.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

activation of immune response

Any process that initiates an immune response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

positive regulation of cell communication

Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

regulation of protein kinase cascade

Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

positive regulation of protein kinase cascade

Any process that increases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

positive regulation of protein kinase cascade

Any process that increases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

activation of plasma proteins during acute inflammatory response

Any process activating plasma proteins via proteolysis during an acute inflammatory response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

lytic vacuole

A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

MHC class I protein complex

A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.

lysosome

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

cell surface

The external part of the cell wall and/or plasma membrane.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

all

This term is the most general term possible

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

protein binding

Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

serine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.

serine-type peptidase activity

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

receptor binding

Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transmembrane receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

growth factor binding

Interacting selectively with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

peptidase activity, acting on L-amino acid peptides

Catalysis of the hydrolysis of peptide bonds formed between L-amino acids.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

serine hydrolase activity

Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

MHC class I receptor activity

Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

This term is the most general term possible

serine-type peptidase activity

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

serine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Id	Pvalue	ExpCount	Count	Size	Term
GO:0002376	5.104e-11	20.83	59 C1R, C1RL, C1S, CBLB, CCBP2, CCL2, CCRL1, CD55, CD97, CFH, CFHR1, CLEC7A, CRHR1, CSF1, DNASE2, DPP4, EDN1, ERAP1, ERAP2, FAS, GEM, GPR183, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HMOX1, HOXB7, ICAM1, IL11, IL1RAP, IL1RL1, IL23A, IL6, IL6ST, IL8, ITGA1, JARID2, LIF, LY96, NFIL3, NFKB1, NP, OSTM1, PSMB8, PSMB9, RUNX1, SECTM1, SHB, SIX1, SOX4, TAPBPL, TNFRSF14, TNFSF4, TPD52, TRIM22, VEGFA	475	immune system process
GO:0006955	1.046e-08	12.94	41 C1R, C1RL, C1S, CBLB, CCBP2, CCL2, CCRL1, CD55, CD97, CFH, CFHR1, CLEC7A, CRHR1, ERAP1, ERAP2, FAS, GEM, GPR183, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HMOX1, ICAM1, IL1RAP, IL1RL1, IL23A, IL6, IL6ST, IL8, LIF, LY96, NFIL3, PSMB8, PSMB9, SECTM1, TNFRSF14, TNFSF4, TRIM22	295	immune response
GO:0032501	8.300e-08	72.28	121 ACSL1, ADRA2A, ANGPTL4, ANO1, BICC1, BMPR2, CCBP2, CCL2, CDH13, COL13A1, COL15A1, COL18A1, CORIN, CREG1, CSF1, CST3, DCN, DES, DGKD, DKK2, DNASE2, EDN1, EGR2, EGR3, EPHB3, ERAP1, ERAP2, F10, F3, FAS, FGF2, FGF5, FGF7, FNDC3A, FOSB, FURIN, GAA, GAP43, GDF11, GPNMB, GRIK2, HBEGF, HEXA, HHEX, HK2, HLX, HMOX1, HOXB6, HOXB7, HSPB7, HTR2A, HTR2B, IDUA, IL11, IL23A, IL6, IL6ST, IL8, ITM2B, ITPR3, JARID2, KCNN4, LBH, LIF, MAN2B1, MAP1S, MEIS1, MEOX1, NFKB1, NINJ1, NOVA1, NP, NPTX1, NR3C1, NR4A3, NRXN3, OR10C1, OSTM1, P2RX4, PDGFA, PDLIM3, PLAUR, PPARD, PROS1, RPS4Y1, RUNX1, SECTM1, SEMA4G, SEMA5A, SEPP1, SFRP1, SGCE, SHB, SIX1, SLC19A2, SLC1A1, SLC22A18, SMARCC1, SOX11, SOX4, SPATA20, SPRED2, SPRY2, SPRY4, SRF, STBD1, TBX3, TCOF1, TCTN1, TFPI, THBD, TNFAIP2, TNFRSF11B, TNS3, TNXB, TPD52, TPP1, USP22, UTP3, VEGFA, ZMYM6	1648	multicellular organismal process
GO:0009605	2.715e-07	16.23	44 ADIPOR2, C1R, C1RL, C1S, CCBP2, CCL2, CCRL1, CD55, CD97, CDH13, CFH, CFHR1, CLEC7A, EDN1, EGR2, F10, F3, FGF2, FGF7, GAP43, HBEGF, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, ITGA1, JMJD3, LY96, NFKB1, NINJ1, NPC1, NR4A3, PDGFA, PLAUR, PPARD, PROS1, SLC10A3, SRF, TFPI, THBD, TPST1, VEGFA	370	response to external stimulus
GO:0009611	4.107e-07	10.13	33 C1R, C1RL, C1S, CCL2, CD55, CD97, CFH, CFHR1, CLEC7A, EDN1, F10, F3, FGF7, GAP43, HBEGF, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, JMJD3, LY96, NFKB1, NINJ1, PDGFA, PLAUR, PPARD, PROS1, SRF, TFPI, THBD, TPST1	231	response to wounding
GO:0002474	2.689e-06	0.7456	9 ERAP1, ERAP2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, TAPBPL	17	antigen processing and presentation of peptide antigen via MHC class I
GO:0050896	3.583e-06	59.21	100 ADIPOR2, ADRA2A, ANGPTL4, BDKRB1, C1R, C1RL, C1S, CBLB, CCBP2, CCL2, CCRL1, CD55, CD97, CDH13, CFH, CFHR1, CLEC7A, CRHR1, CST3, DGKD, DPP4, EDN1, EGLN2, EGR2, ERAP1, ERAP2, F10, F3, FAS, FGF2, FGF7, FOSB, GAA, GAP43, GEM, GPR183, GPX3, GRIK2, HBEGF, HEXA, HIST1H2BK, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HMOX1, HSPB7, HTR2A, ICAM1, IFITM1, IL1RAP, IL1RL1, IL23A, IL6, IL6ST, IL8, ITGA1, JMJD3, KCNN4, LGALS3BP, LIF, LY96, MAN2B1, MAP3K4, NFIL3, NFKB1, NINJ1, NLGN4X, NOVA1, NPC1, NR3C1, NR4A3, OR10C1, P2RX4, PDGFA, PLAUR, PMAIP1, PPARD, PROS1, PSMB8, PSMB9, SECTM1, SEPP1, SETX, SLC10A3, SLC22A18, SOCS2, SOD3, SRF, TFPI, THBD, TNFRSF14, TNFSF4, TP53I11, TPST1, TRIB1, TRIM22, VEGFA	1350	response to stimulus
GO:0032502	5.022e-06	83.46	128 ADIPOR2, ANGPTL4, ANO1, BICC1, BMPR2, CASP1, CASP4, CCBP2, CCL2, CDC42SE1, CDH13, COL13A1, COL15A1, COL18A1, CORIN, CREG1, CSF1, CST3, DCN, DGKD, DKK2, DNASE2, DOCK1, EDN1, EGLN2, EGR2, EGR3, EPHB3, ERAP1, ESM1, FAS, FGF2, FGF5, FGF7, FNDC3A, FOSB, FURIN, GAA, GAP43, GDF11, GNPTAB, GPNMB, GRIK2, HBEGF, HEXA, HHEX, HLX, HMOX1, HOXB6, HOXB7, HTR2A, HTR2B, HTRA1, IDUA, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, ITM2B, JARID2, LBH, LIF, LITAF, LTBR, MAP1S, MEIS1, MEOX1, MTSS1, NFKB1, NINJ1, NP, NPTX1, NR3C1, NR4A3, NRXN3, OSTM1, P2RX4, PDGFA, PDLIM3, PEG3, PMAIP1, PPARD, RPS4Y1, RUNX1, SCML2, SECTM1, SEMA4G, SEMA5A, SEPP1, SERPINB2, SETX, SFRP1, SGCE, SHB, SIX1, SMARCC1, SOCS2, SOX11, SOX4, SPATA20, SPRED2, SPRY2, SPRY4, SRF, SULF1, TBX3, TCOF1, TCTN1, THBD, TM2D1, TNFAIP2, TNFAIP8, TNFRSF11B, TNFRSF14, TNFRSF1B, TNS3, TP53BP2, TPD52, TPP1, TRAF1, TRAF3, USP22, UTP3, VEGFA, WISP2, ZMYM6	1903	developmental process
GO:0007275	1.897e-05	56.32	94 ANGPTL4, ANO1, BICC1, BMPR2, CCBP2, CCL2, CDH13, COL13A1, COL15A1, COL18A1, CREG1, CSF1, CST3, DCN, DGKD, DKK2, DNASE2, EDN1, EGR2, EGR3, EPHB3, ERAP1, FAS, FGF2, FGF5, FGF7, FNDC3A, FOSB, GAA, GAP43, GDF11, GPNMB, HBEGF, HEXA, HHEX, HLX, HMOX1, HOXB6, HOXB7, HTR2B, IDUA, IL11, IL6, IL6ST, IL8, ITM2B, JARID2, LBH, LIF, MAP1S, MEIS1, MEOX1, NFKB1, NINJ1, NP, NPTX1, NR3C1, NR4A3, NRXN3, OSTM1, PDGFA, PDLIM3, PPARD, RPS4Y1, RUNX1, SECTM1, SEMA4G, SEMA5A, SEPP1, SFRP1, SGCE, SHB, SIX1, SMARCC1, SOX11, SOX4, SPATA20, SPRED2, SPRY2, SPRY4, SRF, TBX3, TCOF1, TCTN1, THBD, TNFAIP2, TNFRSF11B, TNS3, TPD52, TPP1, USP22, UTP3, VEGFA, ZMYM6	1284	multicellular organismal development
GO:0048002	2.295e-05	0.9211	9 ERAP1, ERAP2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, TAPBPL	21	antigen processing and presentation of peptide antigen
GO:0019882	1.378e-04	1.754	11 ERAP1, ERAP2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, ICAM1, PSMB8, TAPBPL	40	antigen processing and presentation
GO:0042060	2.710e-04	3.509	15 EDN1, F10, F3, GAP43, HBEGF, HMOX1, IL6, NINJ1, PDGFA, PLAUR, PPARD, PROS1, SRF, TFPI, THBD	80	wound healing
GO:0048513	2.741e-04	32.59	60 ANGPTL4, BMPR2, CCL2, CDH13, COL15A1, COL18A1, CSF1, CST3, DCN, DNASE2, EDN1, EGR2, EGR3, ERAP1, FAS, FGF2, FGF7, FNDC3A, GAA, GAP43, GDF11, GPNMB, HBEGF, HHEX, HMOX1, HOXB6, HOXB7, HTR2B, IDUA, IL11, IL6, IL8, JARID2, LIF, MAP1S, NFKB1, NINJ1, NP, NR3C1, NR4A3, OSTM1, PDLIM3, PPARD, RUNX1, SECTM1, SEMA5A, SEPP1, SGCE, SHB, SIX1, SMARCC1, SOX4, SPRY2, SRF, TBX3, TNFAIP2, TNFRSF11B, TNS3, TPD52, VEGFA	743	organ development
GO:0007610	4.815e-04	7.281	22 CCBP2, CCL2, CCRL1, CDH13, EDN1, EGR2, FGF2, FOSB, GAA, HEXA, HTR2A, IL6, IL8, ITGA1, MAN2B1, NLGN4X, NOVA1, NR4A3, PDGFA, PLAUR, SEPP1, VEGFA	166	behavior
GO:0048856	8.552e-04	54.08	85 ADIPOR2, ANGPTL4, BMPR2, CCL2, CDC42SE1, CDH13, COL15A1, COL18A1, CORIN, CSF1, CST3, DCN, DGKD, DNASE2, EDN1, EGLN2, EGR2, EGR3, EPHB3, ERAP1, ESM1, FAS, FGF2, FGF5, FGF7, FNDC3A, GAA, GAP43, GDF11, GPNMB, HBEGF, HEXA, HHEX, HMOX1, HOXB6, HOXB7, HTR2B, HTRA1, IDUA, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, ITM2B, JARID2, LIF, MAP1S, MTSS1, NFKB1, NINJ1, NP, NPTX1, NR3C1, NR4A3, NRXN3, OSTM1, PDLIM3, PPARD, RUNX1, SCML2, SECTM1, SEMA4G, SEMA5A, SEPP1, SFRP1, SGCE, SHB, SIX1, SMARCC1, SOCS2, SOX11, SOX4, SPRY2, SRF, TBX3, TCOF1, TNFAIP2, TNFRSF11B, TNS3, TPD52, TPP1, VEGFA, WISP2	1233	anatomical structure development
GO:0006928	8.661e-04	11.8	29 ADRA2A, CCL2, CD97, CDH13, CSF1, EDN1, EGR2, EPHB3, FGF2, GAP43, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, MTSS1, NRXN3, PDGFA, PLAUR, PPAP2A, PPARD, SEMA5A, SIX1, SRF, TNS3, TRIB1, VEGFA	269	cell motion
GO:0051674	8.661e-04	11.8	29 ADRA2A, CCL2, CD97, CDH13, CSF1, EDN1, EGR2, EPHB3, FGF2, GAP43, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, MTSS1, NRXN3, PDGFA, PLAUR, PPAP2A, PPARD, SEMA5A, SIX1, SRF, TNS3, TRIB1, VEGFA	269	localization of cell
GO:0007626	1.019e-03	4.43	16 CCBP2, CCL2, CCRL1, CDH13, EDN1, FGF2, GAA, HEXA, IL6, IL8, ITGA1, NOVA1, PDGFA, PLAUR, SEPP1, VEGFA	101	locomotory behavior
GO:0010646	1.830e-03	18.42	38 ASAP2, CASP1, CDH13, DKK2, ECM1, EDN1, EGR2, GRIK2, HHEX, HMOX1, HTR2A, HTR2B, HTRA1, IGFBP5, IL11, IL1RL1, IL6, IL6ST, LIF, LITAF, LTBR, MAP3K7IP2, NPC1, P2RX4, PPARD, RAMP1, RAPGEF2, RGS2, RGS3, SECTM1, SOCS2, SOX4, SPRED2, SPRY2, SPRY4, TRAF3IP2, TRIB1, VEGFA	420	regulation of cell communication
GO:0009887	1.927e-03	13.68	31 ANGPTL4, CCL2, CDH13, COL15A1, COL18A1, CST3, DCN, EDN1, ERAP1, FGF2, GAA, GDF11, HHEX, HMOX1, HOXB6, HOXB7, IDUA, IL6, IL8, JARID2, NR4A3, SEMA5A, SHB, SIX1, SMARCC1, SPRY2, SRF, TBX3, TNFAIP2, TNFRSF11B, VEGFA	312	organ morphogenesis
GO:0007155	2.173e-03	16.49	35 AEBP1, AJAP1, BCAN, CCL2, CD58, CD97, CDH13, COL13A1, COL14A1, COL15A1, COL18A1, CSF1, DPP4, DPT, FNDC3A, GPNMB, ICAM1, IGFBP7, IL8, ITGA1, LGALS3BP, MTSS1, NID1, NINJ1, NLGN4X, NRXN3, PCDH7, PKP2, PPARD, SCARB1, SCARB2, SEMA5A, SGCE, SVEP1, WISP2	376	cell adhesion
GO:0022610	2.173e-03	16.49	35 AEBP1, AJAP1, BCAN, CCL2, CD58, CD97, CDH13, COL13A1, COL14A1, COL15A1, COL18A1, CSF1, DPP4, DPT, FNDC3A, GPNMB, ICAM1, IGFBP7, IL8, ITGA1, LGALS3BP, MTSS1, NID1, NINJ1, NLGN4X, NRXN3, PCDH7, PKP2, PPARD, SCARB1, SCARB2, SEMA5A, SGCE, SVEP1, WISP2	376	biological adhesion
GO:0007166	2.525e-03	30.61	54 ADRA2A, BDKRB1, BMPR2, CBLB, CCBP2, CCL2, CCRL1, CD97, CDH13, CPZ, CRHR1, DGKD, DKK2, DOCK1, EDN1, EPHB3, FGF2, FGF5, FGF7, GAP43, GEM, GNAL, GPR183, GPR37, GRIK2, HBEGF, HHEX, HTR2A, HTR2B, HTRA1, IFITM1, IGFBP5, IL6, IL6ST, IL8, ITGA1, ITPR3, LGR4, LIF, LY96, MTSS1, OR10C1, PDGFA, PPAP2A, RAMP1, RGS2, RGS3, SFRP1, SOCS2, SOX4, TAC3, TNFRSF14, TRIB1, VEGFA	698	cell surface receptor linked signal transduction
GO:0048731	2.699e-03	44.25	71 ANGPTL4, BMPR2, CCL2, CDH13, COL15A1, COL18A1, CSF1, CST3, DCN, DNASE2, EDN1, EGR2, EGR3, EPHB3, ERAP1, FAS, FGF2, FGF5, FGF7, FNDC3A, GAA, GAP43, GDF11, GPNMB, HBEGF, HEXA, HHEX, HMOX1, HOXB6, HOXB7, HTR2B, IDUA, IL11, IL6, IL6ST, IL8, ITM2B, JARID2, LIF, MAP1S, NFKB1, NINJ1, NP, NPTX1, NR3C1, NR4A3, NRXN3, OSTM1, PDLIM3, PPARD, RUNX1, SECTM1, SEMA4G, SEMA5A, SEPP1, SGCE, SHB, SIX1, SMARCC1, SOX11, SOX4, SPRY2, SRF, TBX3, TCOF1, TNFAIP2, TNFRSF11B, TNS3, TPD52, TPP1, VEGFA	1009	system development
GO:0042127	2.743e-03	16.71	35 ADRA2A, BMPR2, CCL2, CDH13, COL18A1, CSF1, EDN1, FGF2, FGF7, GDF11, GPNMB, HBEGF, HHEX, HMOX1, HTR2A, IFITM1, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, LIF, NAMPT, NP, PDGFA, PPAP2A, SOX4, TBX3, TNFSF4, TNS3, TP53I11, TRIB1, VEGFA	381	regulation of cell proliferation
GO:0048583	2.849e-03	5.395	17 C1R, C1RL, C1S, CD55, CDH13, CFH, CFHR1, EDN1, ERAP1, HMOX1, ICAM1, IL6, IL6ST, IL8, NPC1, PDGFA, VEGFA	123	regulation of response to stimulus
GO:0010647	3.015e-03	6.535	19 CASP1, CDH13, ECM1, GRIK2, HMOX1, HTR2B, IL11, IL6, IL6ST, LIF, LITAF, LTBR, MAP3K7IP2, P2RX4, PPARD, SECTM1, SOX4, TRAF3IP2, VEGFA	149	positive regulation of cell communication
GO:0048518	3.312e-03	38.07	63 ABLIM3, ADRA2A, ANGPTL4, BMPR2, C1R, C1RL, C1S, CASP1, CASP4, CCL2, CD55, CDH13, CFH, CFHR1, CSF1, ECM1, EDN1, EGLN2, EGR2, ERAP1, FAS, FGF2, FGF7, FURIN, GRIK2, HBEGF, HHEX, HMOX1, HTR2A, HTR2B, ICAM1, IL11, IL6, IL6ST, IL8, KCNN4, LIF, LITAF, LTBR, MAP3K7IP2, MEOX1, NAMPT, NFKB1, NP, NR4A3, P2RX4, PDGFA, PMAIP1, PPARD, RUNX1, SECTM1, SMARCC1, SOX4, SRF, TBX3, TM2D1, TNFSF4, TNS3, TP53BP2, TRAF3, TRAF3IP2, USP22, VEGFA	868	positive regulation of biological process
GO:0007154	3.365e-03	85.39	118 ADIPOR2, ADRA2A, ANGPTL4, ANK2, ASAP2, BDKRB1, BMPR2, CASP1, CBLB, CCBP2, CCL2, CCRL1, CD97, CDC42SE1, CDH13, CLEC7A, CPZ, CRHR1, DGKD, DKK2, DOCK1, ECM1, EDN1, EGLN2, EGR2, EGR3, EPHB3, FAS, FGF2, FGF5, FGF7, GAP43, GEM, GNAL, GPR183, GPR37, GRIK2, GRN, HBEGF, HEXA, HHEX, HMOX1, HTR2A, HTR2B, HTRA1, IFITM1, IGFBP5, IL11, IL15RA, IL1RAP, IL1RL1, IL6, IL6ST, IL8, INPP1, ITGA1, ITPR3, LGALS3BP, LGR4, LIF, LITAF, LTBR, LY96, LYN, MAP3K4, MAP3K7IP2, MFAP4, MTSS1, NAMPT, NFATC1, NFKB1, NOVA1, NPC1, NPTX1, NR3C1, OR10C1, P2RX4, PDGFA, PIK3CD, PLAUR, PMAIP1, PMEPA1, PPAP2A, PPARD, RALGPS2, RAMP1, RAPGEF2, RCAN2, RGS2, RGS3, RRAD, SECTM1, SEMA5A, SFRP1, SHB, SIX1, SLC1A1, SOCS2, SOX4, SPRED2, SPRY2, SPRY4, STARD13, STK38L, TAC3, TBX3, TEX2, TNFRSF11B, TNFRSF14, TNFSF4, TNXB, TP53BP2, TRAF1, TRAF3, TRAF3IP2, TRIB1, VEGFA, WISP2	1947	cell communication
GO:0006952	3.511e-03	11.54	27 C1R, C1RL, C1S, CCL2, CD55, CD97, CFH, CFHR1, CLEC7A, CST3, ERAP1, HIST1H2BK, HLA-B, HLA-G, HMOX1, IL1RAP, IL1RL1, IL23A, IL6, IL6ST, IL8, JMJD3, KCNN4, LGALS3BP, LY96, NFKB1, TPST1	263	defense response
GO:0006959	3.689e-03	1.316	8 C1R, C1RL, C1S, CCL2, CD55, CFH, CFHR1, IL6	30	humoral immune response
GO:0050900	3.689e-03	1.316	8 CCL2, EDN1, HMOX1, ICAM1, IL6, IL8, ITGA1, VEGFA	30	leukocyte migration
GO:0009653	3.878e-03	30.39	53 ADIPOR2, ANGPTL4, BMPR2, CCL2, CDC42SE1, CDH13, COL15A1, COL18A1, CORIN, CST3, DCN, DGKD, EDN1, EGLN2, EGR2, EPHB3, ERAP1, ESM1, FGF2, GAA, GAP43, GDF11, HHEX, HMOX1, HOXB6, HOXB7, HTRA1, IDUA, IGFBP5, IGFBP7, IL6, IL8, JARID2, MAP1S, MTSS1, NINJ1, NR4A3, NRXN3, SCML2, SEMA5A, SFRP1, SHB, SIX1, SMARCC1, SOCS2, SPRY2, SRF, TBX3, TNFAIP2, TNFRSF11B, TPD52, VEGFA, WISP2	693	anatomical structure morphogenesis
GO:0030335	4.084e-03	1.711	9 CDH13, CSF1, EDN1, FGF2, HBEGF, ICAM1, IL6, PDGFA, VEGFA	39	positive regulation of cell migration
GO:0006954	4.140e-03	6.711	19 C1R, C1RL, C1S, CCL2, CD55, CD97, CFH, CFHR1, CLEC7A, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, JMJD3, LY96, NFKB1, TPST1	153	inflammatory response
GO:0009967	4.159e-03	6.14	18 CASP1, CDH13, ECM1, HMOX1, HTR2B, IL11, IL6, IL6ST, LIF, LITAF, LTBR, MAP3K7IP2, P2RX4, PPARD, SECTM1, SOX4, TRAF3IP2, VEGFA	140	positive regulation of signal transduction
GO:0006935	4.344e-03	3.026	12 CCBP2, CCL2, CCRL1, CDH13, EDN1, FGF2, IL6, IL8, ITGA1, PDGFA, PLAUR, VEGFA	69	chemotaxis
GO:0042330	4.344e-03	3.026	12 CCBP2, CCL2, CCRL1, CDH13, EDN1, FGF2, IL6, IL8, ITGA1, PDGFA, PLAUR, VEGFA	69	taxis
GO:0001525	4.724e-03	4.561	15 ANGPTL4, CDH13, COL15A1, EDN1, ERAP1, FGF2, HHEX, HMOX1, IL6, IL8, SEMA5A, SHB, SRF, TNFAIP2, VEGFA	104	angiogenesis
GO:0009966	4.759e-03	16.54	34 ASAP2, CASP1, CDH13, DKK2, ECM1, EDN1, HHEX, HMOX1, HTR2B, HTRA1, IGFBP5, IL11, IL1RL1, IL6, IL6ST, LIF, LITAF, LTBR, MAP3K7IP2, P2RX4, PPARD, RAMP1, RAPGEF2, RGS2, RGS3, SECTM1, SOCS2, SOX4, SPRED2, SPRY2, SPRY4, TRAF3IP2, TRIB1, VEGFA	377	regulation of signal transduction
GO:0044057	4.870e-03	3.553	13 BMPR2, DES, EDN1, EGR2, GAA, GRIK2, HBEGF, HMOX1, HSPB7, HTR2A, IL6ST, P2RX4, SRF	81	regulation of system process
GO:0016477	5.746e-03	7.5	20 CCL2, CDH13, CSF1, EDN1, FGF2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, PDGFA, PPAP2A, PPARD, SIX1, SRF, TNS3, TRIB1, VEGFA	171	cell migration
GO:0002541	5.917e-03	0.7456	6 C1R, C1RL, C1S, CD55, CFH, CFHR1	17	activation of plasma proteins during acute inflammatory response
GO:0006956	5.917e-03	0.7456	6 C1R, C1RL, C1S, CD55, CFH, CFHR1	17	complement activation
GO:0040012	6.043e-03	3.64	13 CDH13, CSF1, EDN1, FGF2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, PDGFA, TRIB1, VEGFA	83	regulation of locomotion
GO:0051239	6.327e-03	14.04	30 ANGPTL4, BMPR2, CSF1, CST3, DES, EDN1, EGR2, ERAP1, FAS, FGF2, FURIN, GAA, GRIK2, HBEGF, HHEX, HMOX1, HSPB7, HTR2A, IL6, IL6ST, LIF, NFKB1, NP, P2RX4, PDGFA, RUNX1, SIX1, SRF, TBX3, TNFRSF11B	320	regulation of multicellular organismal process
GO:0048646	6.592e-03	6.404	18 ANGPTL4, BMPR2, CDH13, COL15A1, EDN1, EGR2, ERAP1, FGF2, HHEX, HMOX1, IL6, IL8, NR4A3, SEMA5A, SHB, SRF, TNFAIP2, VEGFA	146	anatomical structure formation
GO:0008284	7.473e-03	8.289	21 ADRA2A, CCL2, CDH13, CSF1, EDN1, FGF2, FGF7, HBEGF, HTR2A, IL11, IL6, IL6ST, LIF, NAMPT, NP, PDGFA, SOX4, TBX3, TNFSF4, TNS3, VEGFA	189	positive regulation of cell proliferation
GO:0002682	8.151e-03	6.535	18 C1R, C1RL, C1S, CD55, CFH, CFHR1, CSF1, ERAP1, FAS, HMOX1, ICAM1, IL6, IL6ST, LIF, NFKB1, NP, RUNX1, VEGFA	149	regulation of immune system process
GO:0010740	8.264e-03	4.298	14 CASP1, ECM1, HMOX1, HTR2B, IL11, IL6, IL6ST, LIF, LITAF, LTBR, MAP3K7IP2, PPARD, SECTM1, TRAF3IP2	98	positive regulation of protein kinase cascade
GO:0048870	8.509e-03	7.763	20 CCL2, CDH13, CSF1, EDN1, FGF2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, PDGFA, PPAP2A, PPARD, SIX1, SRF, TNS3, TRIB1, VEGFA	177	cell motility
GO:0030334	8.614e-03	3.289	12 CDH13, CSF1, EDN1, FGF2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, PDGFA, TRIB1, VEGFA	75	regulation of cell migration
GO:0048514	8.954e-03	5.439	16 ANGPTL4, CDH13, COL15A1, CST3, EDN1, ERAP1, FGF2, HHEX, HMOX1, IL6, IL8, SEMA5A, SHB, SRF, TNFAIP2, VEGFA	124	blood vessel morphogenesis
GO:0051272	9.229e-03	1.93	9 CDH13, CSF1, EDN1, FGF2, HBEGF, ICAM1, IL6, PDGFA, VEGFA	44	positive regulation of cell motion
GO:0007186	9.632e-03	10.39	24 ADRA2A, BDKRB1, CCBP2, CCL2, CCRL1, CD97, CRHR1, DGKD, EDN1, GAP43, GNAL, GPR183, GPR37, HTR2A, HTR2B, IL8, ITPR3, LGR4, OR10C1, PPAP2A, RAMP1, RGS2, RGS3, TAC3	237	G-protein coupled receptor protein signaling pathway
GO:0001775	1.001e-02	6.667	18 CLEC7A, CSF1, DPP4, EDN1, FAS, HMOX1, ICAM1, IL11, IL23A, IL6, IL6ST, IL8, NP, P2RX4, PDGFA, SHB, SOX4, TPD52	152	cell activation
GO:0065008	1.026e-02	28.64	49 ADIPOR2, BDKRB1, BMPR2, CCL2, CD55, CDC42SE1, CORIN, DGKD, DNASE2, EDN1, EGLN2, EGR2, ERAP1, ERAP2, ESM1, F10, F3, FAS, FURIN, GAA, HEXA, HMOX1, HOXB6, HSD17B11, HTR2A, HTRA1, IDUA, IGFBP5, IGFBP7, IL11, IL6, ITPR3, KCNN4, LIF, NPC1, NPC2, NR3C1, P2RX4, PDGFA, PLAUR, PROS1, SOCS2, SRF, TBX3, TFPI, THBD, TPP1, VEGFA, WISP2	653	regulation of biological quality
GO:0007165	1.084e-02	78.95	108 ADIPOR2, ADRA2A, ANGPTL4, ANK2, ASAP2, BDKRB1, BMPR2, CASP1, CBLB, CCBP2, CCL2, CCRL1, CD97, CDC42SE1, CDH13, CLEC7A, CPZ, CRHR1, DGKD, DKK2, DOCK1, ECM1, EDN1, EGLN2, EPHB3, FAS, FGF2, FGF5, FGF7, GAP43, GEM, GNAL, GPR183, GPR37, GRIK2, GRN, HBEGF, HHEX, HMOX1, HTR2A, HTR2B, HTRA1, IFITM1, IGFBP5, IL11, IL15RA, IL1RAP, IL1RL1, IL6, IL6ST, IL8, INPP1, ITGA1, ITPR3, LGALS3BP, LGR4, LIF, LITAF, LTBR, LY96, LYN, MAP3K4, MAP3K7IP2, MFAP4, MTSS1, NAMPT, NFATC1, NFKB1, NR3C1, OR10C1, P2RX4, PDGFA, PIK3CD, PLAUR, PMAIP1, PMEPA1, PPAP2A, PPARD, RALGPS2, RAMP1, RAPGEF2, RCAN2, RGS2, RGS3, RRAD, SECTM1, SFRP1, SHB, SOCS2, SOX4, SPRED2, SPRY2, SPRY4, STARD13, STK38L, TAC3, TEX2, TNFRSF11B, TNFRSF14, TNFSF4, TNXB, TP53BP2, TRAF1, TRAF3, TRAF3IP2, TRIB1, VEGFA, WISP2	1800	signal transduction
GO:0051241	1.224e-02	2.018	9 BMPR2, CST3, EDN1, FURIN, HMOX1, HTR2A, IL6, P2RX4, PDGFA	46	negative regulation of multicellular organismal process
GO:0048869	1.257e-02	36.14	58 ADIPOR2, ANGPTL4, BMPR2, CDC42SE1, CDH13, COL13A1, COL15A1, CSF1, DGKD, DNASE2, EDN1, EGLN2, EGR2, EPHB3, ERAP1, ESM1, FAS, FGF2, FGF5, FNDC3A, GAP43, GDF11, GNPTAB, GPNMB, HHEX, HLX, HOXB7, HTRA1, IDUA, IGFBP5, IGFBP7, IL11, IL6, IL6ST, LIF, MAP1S, MTSS1, NFKB1, NP, NRXN3, OSTM1, PPARD, RUNX1, SEMA4G, SEMA5A, SFRP1, SHB, SIX1, SOCS2, SOX4, SPATA20, SPRY2, SRF, TBX3, TNFAIP2, TPD52, VEGFA, WISP2	824	cellular developmental process
GO:0003013	1.297e-02	3.991	13 BMPR2, CORIN, DES, EDN1, ERAP1, ERAP2, GAA, HBEGF, HMOX1, HSPB7, HTR2A, HTR2B, P2RX4	91	circulatory system process
GO:0008015	1.297e-02	3.991	13 BMPR2, CORIN, DES, EDN1, ERAP1, ERAP2, GAA, HBEGF, HMOX1, HSPB7, HTR2A, HTR2B, P2RX4	91	blood circulation
GO:0040011	1.304e-02	10	23 CCBP2, CCL2, CCRL1, CDH13, CSF1, EDN1, FGF2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, PDGFA, PLAUR, PPAP2A, PPARD, SIX1, SRF, TNS3, TRIB1, VEGFA	228	locomotion
GO:0002526	1.344e-02	1.623	8 C1R, C1RL, C1S, CD55, CFH, CFHR1, IL6, IL6ST	37	acute inflammatory response
GO:0065007	1.384e-02	165.3	197 ABLIM3, ACSL1, ADIPOR2, ADRA2A, AEBP1, ANGPTL4, ANK2, ARID5A, ASAP2, BCL7A, BCORL1, BDKRB1, BMPR2, C1R, C1RL, C1S, CASP1, CASP4, CBLB, CCBP2, CCL2, CCRL1, CD55, CD97, CDC42SE1, CDH13, CFH, CFHR1, CLEC7A, COL18A1, CORIN, CPZ, CREG1, CRHR1, CSF1, CST3, DES, DGKD, DKK2, DNAJC1, DNASE2, DOCK1, DPP4, ECM1, EDN1, EGLN2, EGR2, EGR3, EPHB3, ERAP1, ERAP2, ESM1, F10, F3, FAS, FGF2, FGF5, FGF7, FOSB, FURIN, GAA, GAP43, GDF11, GEM, GNAL, GPNMB, GPR183, GPR37, GRIK2, GRN, HBEGF, HEXA, HHEX, HLX, HMOX1, HOXB6, HOXB7, HSD17B11, HSPB7, HTR2A, HTR2B, HTRA1, ICAM1, IDUA, IFITM1, IGFBP5, IGFBP7, IL11, IL15RA, IL1RAP, IL1RL1, IL6, IL6ST, IL8, INPP1, ITGA1, ITPR3, JARID2, JMJD3, KANK1, KCNN4, KHDRBS3, LBH, LGALS3BP, LGR4, LIF, LITAF, LMCD1, LTBR, LY96, LYN, MAF, MAP3K4, MAP3K7IP2, MAX, MEIS1, MEIS3P1, MEOX1, MFAP4, MTSS1, NAMPT, NFATC1, NFIL3, NFKB1, NP, NPC1, NPC2, NR3C1, NR4A3, OR10C1, P2RX4, PDGFA, PDGFD, PEG3, PIK3CD, PKNOX2, PLAUR, PMAIP1, PMEPA1, PPAP2A, PPARD, PROS1, PSMB8, PSMB9, RALGPS2, RAMP1, RAPGEF2, RCAN2, RGS2, RGS3, RRAD, RUNX1, SCML2, SECTM1, SERPINB2, SFRP1, SHB, SIX1, SMARCC1, SOCS2, SOX11, SOX4, SPRED2, SPRY2, SPRY4, SRF, STARD13, STK38L, TAC3, TBX3, TEX2, TFPI, THBD, TM2D1, TNFAIP8, TNFRSF11B, TNFRSF14, TNFSF4, TNS3, TNXB, TP53BP2, TP53I11, TPP1, TRAF1, TRAF3, TRAF3IP2, TRIB1, TRIM22, USP22, VEGFA, WISP2, WT1, ZBTB20, ZKSCAN3, ZNF143, ZNF35, ZNF672	3768	biological regulation
GO:0048584	1.487e-02	3.026	11 C1R, C1RL, C1S, CD55, CDH13, CFH, CFHR1, IL6, IL6ST, IL8, VEGFA	69	positive regulation of response to stimulus
GO:0010627	1.503e-02	5.175	15 CASP1, ECM1, HMOX1, HTR2B, IL11, IL1RL1, IL6, IL6ST, LIF, LITAF, LTBR, MAP3K7IP2, PPARD, SECTM1, TRAF3IP2	118	regulation of protein kinase cascade
GO:0048660	1.665e-02	0.9211	6 CDH13, EDN1, HBEGF, IGFBP5, IL6, TRIB1	21	regulation of smooth muscle cell proliferation
GO:0014812	1.723e-02	0.3509	4 IGFBP5, PDGFA, SIX1, TRIB1	8	muscle cell migration
GO:0008283	1.754e-02	24.78	43 ADRA2A, BMPR2, CCL2, CDH13, COL18A1, CREG1, CSF1, EDN1, FGF2, FGF5, FGF7, FURIN, GDF11, GPNMB, HBEGF, HHEX, HMOX1, HTR2A, IFITM1, IGFBP5, IGFBP7, IL11, IL15RA, IL23A, IL6, IL6ST, IL8, JARID2, LIF, NAMPT, NP, PDGFA, PDGFD, PPAP2A, PPARD, SHB, SOX4, TBX3, TNFSF4, TNS3, TP53I11, TRIB1, VEGFA	565	cell proliferation
GO:0050878	1.870e-02	2.632	10 EDN1, F10, F3, IL6, KCNN4, PDGFA, PLAUR, PROS1, TFPI, THBD	60	regulation of body fluid levels
GO:0042221	2.015e-02	18.9	35 ADIPOR2, BDKRB1, CCBP2, CCL2, CCRL1, CDH13, CLEC7A, DGKD, EDN1, EGR2, FAS, FGF2, GPX3, GRIK2, HMOX1, HSPB7, HTR2A, IL6, IL6ST, IL8, ITGA1, NPC1, NR3C1, P2RX4, PDGFA, PLAUR, PMAIP1, SEPP1, SLC10A3, SLC22A18, SOCS2, SRF, THBD, TRIB1, VEGFA	431	response to chemical stimulus
GO:0007596	2.036e-02	2.193	9 EDN1, F10, F3, IL6, PDGFA, PLAUR, PROS1, TFPI, THBD	50	blood coagulation
GO:0050817	2.036e-02	2.193	9 EDN1, F10, F3, IL6, PDGFA, PLAUR, PROS1, TFPI, THBD	50	coagulation
GO:0048659	2.065e-02	0.9649	6 CDH13, EDN1, HBEGF, IGFBP5, IL6, TRIB1	22	smooth muscle cell proliferation
GO:0001568	2.205e-02	6.009	16 ANGPTL4, CDH13, COL15A1, CST3, EDN1, ERAP1, FGF2, HHEX, HMOX1, IL6, IL8, SEMA5A, SHB, SRF, TNFAIP2, VEGFA	137	blood vessel development
GO:0045321	2.205e-02	6.009	16 CLEC7A, CSF1, DPP4, EDN1, FAS, HMOX1, ICAM1, IL11, IL23A, IL6, IL6ST, IL8, NP, SHB, SOX4, TPD52	137	leukocyte activation
GO:0050793	2.212e-02	30.66	50 ADIPOR2, ANGPTL4, BMPR2, CASP1, CASP4, CCL2, CDC42SE1, CDH13, CSF1, CST3, DGKD, EDN1, EGLN2, EGR2, ERAP1, ESM1, FAS, FGF2, FURIN, GDF11, GRIK2, HHEX, HMOX1, HTRA1, IGFBP5, IGFBP7, IL6, IL6ST, LIF, NFKB1, NP, P2RX4, PMAIP1, PPARD, RUNX1, SERPINB2, SFRP1, SIX1, SOCS2, SOX4, SRF, TBX3, TM2D1, TNFAIP8, TNFRSF11B, TP53BP2, TRAF1, TRAF3, VEGFA, WISP2	699	regulation of developmental process
GO:0033002	2.226e-02	1.36	7 CDH13, EDN1, FGF2, HBEGF, IGFBP5, IL6, TRIB1	31	muscle cell proliferation
GO:0007598	2.298e-02	0.1754	3 F10, F3, TFPI	4	blood coagulation, extrinsic pathway
GO:0033135	2.298e-02	0.1754	3 IL11, IL6, LIF	4	regulation of peptidyl-serine phosphorylation
GO:0033138	2.298e-02	0.1754	3 IL11, IL6, LIF	4	positive regulation of peptidyl-serine phosphorylation
GO:0003002	2.391e-02	3.246	11 BMPR2, EDN1, EGR2, FGF2, GDF11, HOXB6, HOXB7, MEOX1, SFRP1, SIX1, TBX3	74	regionalization
GO:0050776	2.391e-02	3.246	11 C1R, C1RL, C1S, CD55, CFH, CFHR1, ERAP1, HMOX1, ICAM1, IL6, IL6ST	74	regulation of immune response
GO:0001944	2.490e-02	6.096	16 ANGPTL4, CDH13, COL15A1, CST3, EDN1, ERAP1, FGF2, HHEX, HMOX1, IL6, IL8, SEMA5A, SHB, SRF, TNFAIP2, VEGFA	139	vasculature development
GO:0003008	2.594e-02	20	36 BMPR2, COL18A1, CORIN, DES, EDN1, EGR2, EGR3, ERAP1, ERAP2, FAS, GAA, GRIK2, HBEGF, HEXA, HMOX1, HSPB7, HTR2A, HTR2B, IL6ST, ITM2B, ITPR3, KCNN4, MAN2B1, NOVA1, NPTX1, NR4A3, OR10C1, P2RX4, SIX1, SLC19A2, SLC1A1, SLC22A18, SPRY2, SRF, STBD1, TPP1	456	system process
GO:0002685	2.612e-02	0.3947	4 HMOX1, ICAM1, IL6, VEGFA	9	regulation of leukocyte migration
GO:0007243	2.619e-02	12.72	26 ADRA2A, CASP1, CCL2, ECM1, EDN1, FGF2, HMOX1, HTR2B, IL11, IL1RL1, IL6, IL6ST, LIF, LITAF, LTBR, LY96, MAP3K4, MAP3K7IP2, PPARD, RAPGEF2, RGS3, SECTM1, SOCS2, STK38L, TRAF3IP2, TRIB1	290	protein kinase cascade
GO:0008217	2.995e-02	1.447	7 BMPR2, CORIN, EDN1, ERAP1, ERAP2, HMOX1, P2RX4	33	regulation of blood pressure
GO:0045087	3.043e-02	2.851	10 C1R, C1RL, C1S, CD55, CFH, CLEC7A, ERAP1, IL1RAP, IL1RL1, IL23A	65	innate immune response
GO:0007599	3.133e-02	2.368	9 EDN1, F10, F3, IL6, PDGFA, PLAUR, PROS1, TFPI, THBD	54	hemostasis
GO:0051270	3.221e-02	3.947	12 CDH13, CSF1, EDN1, FGF2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, PDGFA, TRIB1, VEGFA	90	regulation of cell motion
GO:0043500	3.642e-02	0.4386	4 EDN1, HMOX1, IL6ST, P2RX4	10	muscle adaptation
GO:0030595	3.687e-02	0.7456	5 CCL2, EDN1, IL6, IL8, ITGA1	17	leukocyte chemotaxis
GO:0060326	3.687e-02	0.7456	5 CCL2, EDN1, IL6, IL8, ITGA1	17	cell chemotaxis
GO:0008016	4.134e-02	1.14	6 DES, EDN1, GAA, HBEGF, HSPB7, P2RX4	26	regulation of heart contraction
GO:0006950	4.149e-02	37.63	57 ADRA2A, ANGPTL4, C1R, C1RL, C1S, CCL2, CD55, CD97, CFH, CFHR1, CLEC7A, CST3, DPP4, EDN1, EGLN2, ERAP1, F10, F3, FGF7, GAP43, GPX3, HBEGF, HIST1H2BK, HLA-B, HLA-G, HMOX1, HSPB7, HTR2A, IL1RAP, IL1RL1, IL23A, IL6, IL6ST, IL8, JMJD3, KCNN4, LGALS3BP, LY96, MAP3K4, NFKB1, NINJ1, NPC1, P2RX4, PDGFA, PLAUR, PPARD, PROS1, SEPP1, SETX, SOD3, SRF, TFPI, THBD, TP53I11, TPST1, TRIB1, VEGFA	858	response to stress
GO:0051046	4.167e-02	2.5	9 DNAJC1, EDN1, HMOX1, HTR2A, IL11, IL6, KCNN4, LIF, P2RX4	57	regulation of secretion
GO:0019932	4.249e-02	4.123	12 CCL2, CDH13, CRHR1, DGKD, EDN1, HTR2A, HTR2B, IL8, P2RX4, PIK3CD, RAPGEF2, RCAN2	94	second-messenger-mediated signaling
GO:0010611	4.283e-02	0.2193	3 EDN1, IL6ST, P2RX4	5	regulation of cardiac muscle hypertrophy
GO:0010612	4.283e-02	0.2193	3 EDN1, IL6ST, P2RX4	5	regulation of cardiac muscle adaptation
GO:0014743	4.283e-02	0.2193	3 EDN1, IL6ST, P2RX4	5	regulation of muscle hypertrophy
GO:0014887	4.283e-02	0.2193	3 EDN1, IL6ST, P2RX4	5	cardiac muscle adaptation
GO:0014888	4.283e-02	0.2193	3 EDN1, IL6ST, P2RX4	5	striated muscle adaptation
GO:0014897	4.283e-02	0.2193	3 EDN1, IL6ST, P2RX4	5	striated muscle hypertrophy
GO:0014898	4.283e-02	0.2193	3 EDN1, IL6ST, P2RX4	5	cardiac muscle hypertrophy
GO:0031330	4.283e-02	0.2193	3 CST3, FURIN, NPC1	5	negative regulation of cellular catabolic process
GO:0043502	4.283e-02	0.2193	3 EDN1, IL6ST, P2RX4	5	regulation of muscle adaptation
GO:0002684	4.431e-02	3.596	11 C1R, C1RL, C1S, CD55, CFH, CFHR1, ICAM1, IL6, IL6ST, NP, VEGFA	82	positive regulation of immune system process
GO:0007169	4.454e-02	6.579	16 BMPR2, CCL2, CDH13, DGKD, EPHB3, FGF2, FGF5, FGF7, HBEGF, HHEX, IGFBP5, MTSS1, PDGFA, RGS2, SOCS2, VEGFA	150	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0048010	4.796e-02	0.4825	4 BMPR2, CCL2, HHEX, VEGFA	11	vascular endothelial growth factor receptor signaling pathway

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005576	3.126e-20	29.76	90 A2M, AEBP1, ANGPTL4, APOD, BCAN, C1R, C1RL, C1S, CCL2, CD97, CDH13, CFH, CFHR1, COL13A1, COL14A1, COL15A1, COL18A1, CPZ, CREG1, CSF1, CST3, DCN, DKK2, DPP4, DPT, ECM1, EDN1, ERAP1, F10, FAS, FGF2, FGF5, FGF7, FURIN, GDF11, GPLD1, GPX3, GRN, HBEGF, HLA-C, HMOX1, HSD17B11, HTRA1, ICAM1, IGFBP5, IGFBP7, IL11, IL15RA, IL1RAP, IL1RL1, IL23A, IL6, IL6ST, IL8, ITFG1, ITIH2, LGALS3BP, LIF, LY96, MAN2B2, MFAP4, MUC3A, NID1, NPC2, OLFML2A, PDGFA, PDGFD, PLAUR, PROS1, PTGDS, RNASET2, SCPEP1, SECTM1, SEPP1, SERPINB2, SFRP1, SOD3, SULF1, SVEP1, TAC3, TCTN1, TFPI, THBD, TNFAIP2, TNFRSF11B, TNFRSF1B, TNFSF4, TNXB, VEGFA, WISP2	700	extracellular region
GO:0044421	5.885e-13	16.45	54 A2M, ANGPTL4, APOD, BCAN, C1RL, CCL2, CDH13, CFH, CFHR1, COL13A1, COL14A1, COL15A1, COL18A1, CPZ, CSF1, CST3, DCN, DKK2, DPT, ECM1, EDN1, FGF2, FGF5, FURIN, GDF11, GPX3, GRN, HBEGF, HMOX1, HTRA1, ICAM1, IGFBP5, IL11, IL23A, IL6, IL8, LGALS3BP, LIF, MFAP4, NID1, OLFML2A, PDGFA, SECTM1, SEPP1, SFRP1, SOD3, SULF1, TAC3, THBD, TNFAIP2, TNFRSF11B, TNFSF4, TNXB, VEGFA	387	extracellular region part
GO:0005615	1.709e-11	10.46	40 A2M, ANGPTL4, APOD, C1RL, CCL2, CDH13, CFH, CFHR1, CSF1, CST3, DKK2, EDN1, FGF2, FGF5, FURIN, GDF11, GPX3, GRN, HBEGF, HMOX1, HTRA1, ICAM1, IGFBP5, IL11, IL23A, IL6, IL8, LGALS3BP, LIF, PDGFA, SECTM1, SEPP1, SFRP1, SOD3, SULF1, TAC3, THBD, TNFAIP2, TNFSF4, VEGFA	246	extracellular space
GO:0005886	4.799e-05	61.34	97 ADRA2A, AJAP1, ASAP2, BDKRB1, BMPR2, CADPS2, CCBP2, CCRL1, CD55, CD58, CD97, CDC42SE1, CDH13, CHIC2, CLEC2B, COL13A1, CORIN, CRHR1, CSF1, DDX3Y, DES, DGKD, DPP4, EPHB3, F10, F3, FAS, FURIN, GAP43, GEM, GPNMB, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HTR2A, HTR2B, ICAM1, IFITM1, IL1RAP, IL1RL1, IL6, IL6ST, ITGA1, ITPR3, KCNN4, LGR4, LY96, LYN, MAGI2, NEU1, NLGN4X, NPC1, NRXN3, OR10C1, P2RX4, PCDH7, PKP2, PLAUR, PMEPA1, PPAP2A, RALGPS2, RAMP1, RAPGEF2, RGS3, SCARB1, SCARB2, SECTM1, SETD3, SGCE, SHB, SLC16A4, SLC19A2, SLC1A1, SLC20A2, SLC22A18, SLC9A3R2, SPRED2, SPRY2, SPRY4, STBD1, STOM, STXBP5L, TAPBPL, TFPI, THBD, TM2D1, TNFRSF14, TNFRSF1B, TNFSF4, TNS3	1443	plasma membrane
GO:0005887	1.340e-04	23.34	47 ADRA2A, BDKRB1, BMPR2, CCBP2, CCRL1, CD55, CD58, CD97, CLEC2B, CORIN, CRHR1, EPHB3, GPNMB, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HTR2A, HTR2B, ICAM1, IL1RAP, IL6, IL6ST, ITGA1, KCNN4, NLGN4X, NPC1, NRXN3, P2RX4, PCDH7, PPAP2A, RAMP1, RAPGEF2, SCARB2, SGCE, SLC16A4, SLC1A1, SLC20A2, STBD1, STOM, THBD, TM2D1, TNFRSF14, TNFSF4	549	integral to plasma membrane
GO:0031226	1.674e-04	23.55	47 ADRA2A, BDKRB1, BMPR2, CCBP2, CCRL1, CD55, CD58, CD97, CLEC2B, CORIN, CRHR1, EPHB3, GPNMB, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HTR2A, HTR2B, ICAM1, IL1RAP, IL6, IL6ST, ITGA1, KCNN4, NLGN4X, NPC1, NRXN3, P2RX4, PCDH7, PPAP2A, RAMP1, RAPGEF2, SCARB2, SGCE, SLC16A4, SLC1A1, SLC20A2, STBD1, STOM, THBD, TM2D1, TNFRSF14, TNFSF4	554	intrinsic to plasma membrane
GO:0031224	3.440e-04	87.18	123 ACSL1, ADIPOR2, ADRA2A, AJAP1, ANO1, ATP13A3, B4GALT6, BCAN, BDKRB1, BMPR2, C19orf28, C1orf159, C9orf167, CCBP2, CCRL1, CD302, CD55, CD58, CD97, CDH13, CLEC2B, CLEC7A, COL13A1, CORIN, CRHR1, CSF1, CSGALNACT2, CYP51A1, DNAJC1, DPP4, EPHB3, ERAP1, ERAP2, F3, FADS3, FAS, FURIN, GALNT3, GLT8D2, GNPTAB, GPNMB, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HTR2A, HTR2B, ICAM1, IFITM1, IL15RA, IL1RAP, IL1RL1, IL6, IL6ST, ITFG1, ITGA1, ITM2B, ITPR3, KCNN4, KIAA0247, KIAA1644, LGR4, LHFP, LMBRD1, LRIG1, LTBR, MAN1C1, MEGF9, MUC3A, NINJ1, NLGN4X, NPC1, NRXN3, OR10C1, OSTM1, P2RX4, PCDH7, PKP2, PLAUR, PMEPA1, PPAP2A, RAMP1, RAPGEF2, SCARB1, SCARB2, SECTM1, SEMA4G, SEMA5A, SGCE, SLC16A4, SLC17A9, SLC19A2, SLC1A1, SLC20A2, SLC22A18, SLC2A10, SLC39A8, SLCO3A1, STBD1, STOM, STXBP5L, TAPBPL, TEX2, THBD, TM2D1, TM6SF1, TMBIM4, TMEM158, TMEM39A, TMEM41B, TMEM51, TNFRSF14, TNFRSF1B, TNFSF4, TPST1, TPST2, YIPF6	2051	intrinsic to membrane
GO:0016021	4.648e-04	85.95	121 ACSL1, ADIPOR2, ADRA2A, AJAP1, ANO1, ATP13A3, B4GALT6, BDKRB1, BMPR2, C19orf28, C1orf159, C9orf167, CCBP2, CCRL1, CD302, CD55, CD58, CD97, CLEC2B, CLEC7A, COL13A1, CORIN, CRHR1, CSF1, CSGALNACT2, CYP51A1, DNAJC1, DPP4, EPHB3, ERAP1, ERAP2, F3, FADS3, FAS, FURIN, GALNT3, GLT8D2, GNPTAB, GPNMB, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HTR2A, HTR2B, ICAM1, IFITM1, IL15RA, IL1RAP, IL1RL1, IL6, IL6ST, ITFG1, ITGA1, ITM2B, ITPR3, KCNN4, KIAA0247, KIAA1644, LGR4, LHFP, LMBRD1, LRIG1, LTBR, MAN1C1, MEGF9, MUC3A, NINJ1, NLGN4X, NPC1, NRXN3, OR10C1, OSTM1, P2RX4, PCDH7, PKP2, PLAUR, PMEPA1, PPAP2A, RAMP1, RAPGEF2, SCARB1, SCARB2, SECTM1, SEMA4G, SEMA5A, SGCE, SLC16A4, SLC17A9, SLC19A2, SLC1A1, SLC20A2, SLC22A18, SLC2A10, SLC39A8, SLCO3A1, STBD1, STOM, STXBP5L, TAPBPL, TEX2, THBD, TM2D1, TM6SF1, TMBIM4, TMEM158, TMEM39A, TMEM41B, TMEM51, TNFRSF14, TNFRSF1B, TNFSF4, TPST1, TPST2, YIPF6	2022	integral to membrane
GO:0044459	6.525e-04	37.19	63 ADRA2A, AJAP1, BDKRB1, BMPR2, CADPS2, CCBP2, CCRL1, CD55, CD58, CD97, CDH13, CLEC2B, CORIN, CRHR1, DPP4, EPHB3, FAS, GAP43, GPNMB, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HTR2A, HTR2B, ICAM1, IL1RAP, IL1RL1, IL6, IL6ST, ITGA1, ITPR3, KCNN4, MAGI2, NLGN4X, NPC1, NRXN3, P2RX4, PCDH7, PKP2, PPAP2A, RAMP1, RAPGEF2, SCARB2, SGCE, SLC16A4, SLC1A1, SLC20A2, SLC22A18, SLC9A3R2, STBD1, STOM, THBD, TM2D1, TNFRSF14, TNFSF4, TNS3	875	plasma membrane part
GO:0016020	7.378e-04	134.6	172 ACSL1, ADIPOR2, ADRA2A, AJAP1, ANO1, ASAP2, ATP13A3, B4GALT6, BCAN, BDKRB1, BMPR2, C19orf28, C1orf159, C9orf167, CADPS2, CCBP2, CCRL1, CD302, CD55, CD58, CD97, CDC42SE1, CDH13, CHIC2, CLEC2B, CLEC7A, COL13A1, CORIN, CRHR1, CSF1, CSGALNACT2, CYP51A1, DDX3Y, DES, DGKD, DNAJC1, DOCK1, DOCK9, DPP4, DSCR3, EPHB3, ERAP1, ERAP2, F10, F3, FADS3, FAS, FNDC3A, FURIN, GALNT3, GAP43, GEM, GLT8D2, GNPTAB, GPNMB, GPR183, GPR37, GRIK2, HBEGF, HEXA, HK2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HTR2A, HTR2B, ICAM1, IFITM1, IL15RA, IL1RAP, IL1RL1, IL6, IL6ST, ITFG1, ITGA1, ITM2B, ITPR3, KCNN4, KIAA0247, KIAA1644, LEPROT, LGALS3BP, LGR4, LHFP, LITAF, LMBRD1, LRIG1, LTBR, LY96, LYN, MAGI2, MAN1C1, MAP3K7IP2, MEGF9, MUC3A, NEU1, NID1, NINJ1, NLGN4X, NPC1, NR3C1, NRXN3, OLFML2A, OR10C1, OSTM1, P2RX4, PCDH7, PDGFA, PDGFD, PKP2, PLAUR, PLSCR4, PMEPA1, PPAP2A, PTGDS, RALGPS2, RAMP1, RAPGEF2, RGS3, SCARB1, SCARB2, SECTM1, SEMA4G, SEMA5A, SETD3, SGCE, SHB, SLC10A3, SLC16A4, SLC17A9, SLC19A2, SLC1A1, SLC20A2, SLC22A18, SLC2A10, SLC39A8, SLC9A3R2, SLCO3A1, SPRED2, SPRY2, SPRY4, SQRDL, STARD13, STBD1, STOM, STXBP5L, SVEP1, TAPBPL, TEX2, TFPI, THBD, TM2D1, TM6SF1, TMBIM4, TMEM158, TMEM39A, TMEM41B, TMEM51, TNFRSF14, TNFRSF1B, TNFSF4, TNS3, TOM1, TPST1, TPST2, VEGFA, WTAP, YIPF6, YRDC	3167	membrane
GO:0042612	8.865e-04	0.6376	6 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G	15	MHC class I protein complex
GO:0000323	2.660e-03	4.761	15 CTSA, DNASE2, GAA, HEXA, IDS, IDUA, LITAF, MAN2B1, MANBA, NEU1, NPC1, NPC2, SCARB2, SGSH, TPP1	112	lytic vacuole
GO:0005764	2.660e-03	4.761	15 CTSA, DNASE2, GAA, HEXA, IDS, IDUA, LITAF, MAN2B1, MANBA, NEU1, NPC1, NPC2, SCARB2, SGSH, TPP1	112	lysosome
GO:0009986	4.059e-03	5.526	16 BMPR2, CDH13, CORIN, DPP4, FAS, FURIN, HBEGF, ICAM1, IL1RL1, IL6ST, ITGA1, NLGN4X, PDGFA, PLAUR, SULF1, VEGFA	130	cell surface
GO:0042611	7.464e-03	0.9352	6 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G	22	MHC protein complex
GO:0005773	1.153e-02	5.526	15 CTSA, DNASE2, GAA, HEXA, IDS, IDUA, LITAF, MAN2B1, MANBA, NEU1, NPC1, NPC2, SCARB2, SGSH, TPP1	130	vacuole
GO:0031012	1.824e-02	7.056	17 ANGPTL4, BCAN, COL13A1, COL14A1, COL15A1, COL18A1, CPZ, DCN, DPT, ECM1, LGALS3BP, MFAP4, NID1, OLFML2A, TNFRSF11B, TNXB, VEGFA	166	extracellular matrix
GO:0044425	2.294e-02	103.1	130 ACSL1, ADIPOR2, ADRA2A, AJAP1, ANO1, ATP13A3, B4GALT6, BCAN, BDKRB1, BMPR2, C19orf28, C1orf159, C9orf167, CADPS2, CCBP2, CCRL1, CD302, CD55, CD58, CD97, CDH13, CLEC2B, CLEC7A, COL13A1, CORIN, CRHR1, CSF1, CSGALNACT2, CYP51A1, DNAJC1, DPP4, DSCR3, EPHB3, ERAP1, ERAP2, F3, FADS3, FAS, FURIN, GALNT3, GAP43, GLT8D2, GNPTAB, GPNMB, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HTR2A, HTR2B, ICAM1, IFITM1, IL15RA, IL1RAP, IL1RL1, IL6, IL6ST, ITFG1, ITGA1, ITM2B, ITPR3, KCNN4, KIAA0247, KIAA1644, LGR4, LHFP, LMBRD1, LRIG1, LTBR, LYN, MAGI2, MAN1C1, MEGF9, MUC3A, NINJ1, NLGN4X, NPC1, NRXN3, OR10C1, OSTM1, P2RX4, PCDH7, PKP2, PLAUR, PMEPA1, PPAP2A, RAMP1, RAPGEF2, SCARB1, SCARB2, SECTM1, SEMA4G, SEMA5A, SGCE, SLC16A4, SLC17A9, SLC19A2, SLC1A1, SLC20A2, SLC22A18, SLC2A10, SLC39A8, SLC9A3R2, SLCO3A1, STBD1, STOM, STXBP5L, TAPBPL, TEX2, THBD, TM2D1, TM6SF1, TMBIM4, TMEM158, TMEM39A, TMEM41B, TMEM51, TNFRSF14, TNFRSF1B, TNFSF4, TNS3, TPST1, TPST2, YIPF6	2426	membrane part
GO:0005578	2.427e-02	6.631	16 ANGPTL4, BCAN, COL13A1, COL14A1, COL15A1, COL18A1, CPZ, DCN, DPT, ECM1, LGALS3BP, MFAP4, NID1, TNFRSF11B, TNXB, VEGFA	156	proteinaceous extracellular matrix

Id	Pvalue	ExpCount	Count	Size	Term
GO:0004871	1.268e-07	33.23	73 ADIPOR2, ADRA2A, BDKRB1, BMPR2, CBLB, CCBP2, CCL2, CCRL1, CD97, CLEC7A, CORIN, CRHR1, ECM1, EPHB3, FAS, GNAL, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HMOX1, HTR2A, HTR2B, ICAM1, IFITM1, IL15RA, IL1RAP, IL1RL1, IL6ST, ITGA1, ITPR3, LGALS3BP, LGR4, LITAF, LTBR, LY96, LYN, MAP3K4, MEGF9, NPC1, NR3C1, NR4A3, NRXN3, OR10C1, P2RX4, PLAUR, PPARD, RAMP1, RAPGEF2, RGS2, RGS3, SCARB1, SCARB2, SECTM1, SEMA4G, SEMA5A, SH3BGRL, SHB, SLC20A2, SOCS2, THBD, TM2D1, TNFRSF11B, TNFRSF14, TNFRSF1B, TP53BP2, TRAF3	798	signal transducer activity
GO:0060089	1.268e-07	33.23	73 ADIPOR2, ADRA2A, BDKRB1, BMPR2, CBLB, CCBP2, CCL2, CCRL1, CD97, CLEC7A, CORIN, CRHR1, ECM1, EPHB3, FAS, GNAL, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HMOX1, HTR2A, HTR2B, ICAM1, IFITM1, IL15RA, IL1RAP, IL1RL1, IL6ST, ITGA1, ITPR3, LGALS3BP, LGR4, LITAF, LTBR, LY96, LYN, MAP3K4, MEGF9, NPC1, NR3C1, NR4A3, NRXN3, OR10C1, P2RX4, PLAUR, PPARD, RAMP1, RAPGEF2, RGS2, RGS3, SCARB1, SCARB2, SECTM1, SEMA4G, SEMA5A, SH3BGRL, SHB, SLC20A2, SOCS2, THBD, TM2D1, TNFRSF11B, TNFRSF14, TNFRSF1B, TP53BP2, TRAF3	798	molecular transducer activity
GO:0004872	4.299e-07	22.2	55 ADIPOR2, ADRA2A, BDKRB1, BMPR2, CCBP2, CCRL1, CD97, CLEC7A, CORIN, CRHR1, EPHB3, FAS, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HTR2A, HTR2B, ICAM1, IL15RA, IL1RAP, IL1RL1, IL6ST, ITGA1, ITPR3, LGALS3BP, LGR4, LTBR, LY96, MEGF9, NPC1, NR3C1, NR4A3, NRXN3, OR10C1, P2RX4, PLAUR, PPARD, RAMP1, SCARB1, SCARB2, SEMA4G, SEMA5A, SLC20A2, THBD, TM2D1, TNFRSF11B, TNFRSF14, TNFRSF1B	533	receptor activity
GO:0004888	6.037e-05	13.91	36 ADRA2A, BDKRB1, BMPR2, CCBP2, CCRL1, CD97, CORIN, CRHR1, EPHB3, FAS, GPR183, GPR37, GRIK2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HTR2A, HTR2B, ICAM1, IL15RA, IL1RAP, IL1RL1, IL6ST, LGALS3BP, LGR4, NPC1, OR10C1, P2RX4, SEMA5A, THBD, TM2D1, TNFRSF14, TNFRSF1B	334	transmembrane receptor activity
GO:0032393	1.496e-04	0.3748	6 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G	9	MHC class I receptor activity
GO:0005125	1.695e-03	3.04	13 CCL2, CSF1, GRN, IL11, IL23A, IL6, IL8, LIF, NAMPT, SECTM1, TNFRSF11B, TNFSF4, VEGFA	73	cytokine activity
GO:0008236	2.719e-03	2.749	12 C1R, C1RL, C1S, CORIN, CTSA, DPP4, F10, FURIN, HTRA1, SCPEP1, SERPINB2, TPP1	66	serine-type peptidase activity
GO:0017171	2.719e-03	2.749	12 C1R, C1RL, C1S, CORIN, CTSA, DPP4, F10, FURIN, HTRA1, SCPEP1, SERPINB2, TPP1	66	serine hydrolase activity
GO:0008083	4.808e-03	3.915	14 CSF1, ERAP1, FGF2, FGF5, FGF7, GDF11, GRN, HBEGF, IL11, IL6, LIF, PDGFA, PDGFD, VEGFA	94	growth factor activity
GO:0019838	6.962e-03	2.624	11 A2M, ESM1, FURIN, HTRA1, IGFBP5, IGFBP7, IL1RAP, IL1RL1, IL6ST, PDGFA, WISP2	63	growth factor binding
GO:0004252	9.771e-03	2.29	10 C1R, C1RL, C1S, CORIN, DPP4, F10, FURIN, HTRA1, SERPINB2, TPP1	55	serine-type endopeptidase activity
GO:0005102	1.802e-02	16.99	33 ANGPTL4, CCL2, CLEC7A, CSF1, EDN1, ERAP1, FGF2, FGF5, FGF7, GDF11, GPNMB, GRN, HBEGF, ICAM1, IL11, IL23A, IL6, IL6ST, IL8, LIF, MFAP4, MTSS1, NAMPT, P2RX4, PDGFA, PDGFD, PSMB8, SECTM1, SOCS2, TAC3, TNFRSF11B, TNFSF4, VEGFA	408	receptor binding
GO:0005509	2.651e-02	16.74	32 ANO1, B4GALT6, C1R, C1S, CADPS2, CBLB, CD97, CDH13, EFHD1, F10, FURIN, GALNT3, GNPTAB, HPCAL1, IDS, ITGA1, ITPR3, MAN1C1, MFAP4, NID1, NPTX1, NRXN3, PCDH7, PLSCR4, PROS1, RAPGEF2, SGCE, SGSH, SULF1, SVEP1, THBD, TPD52	402	calcium ion binding
GO:0019955	2.683e-02	2.207	9 A2M, CCBP2, CCRL1, IL15RA, IL1RAP, IL1RL1, IL6ST, TNFRSF14, TNFRSF1B	53	cytokine binding
GO:0030246	3.123e-02	5.497	15 BCAN, CD302, CLEC2B, CLEC7A, COL13A1, FGF2, GAA, GALNT3, GPNMB, HBEGF, MAN2B1, MAN2B2, SOD3, STBD1, VEGFA	132	carbohydrate binding
GO:0004553	3.293e-02	1.832	8 GAA, HEXA, IDUA, MAN1C1, MAN2B1, MAN2B2, MANBA, NEU1	44	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005520	4.658e-02	0.7496	5 ESM1, HTRA1, IGFBP5, IGFBP7, WISP2	18	insulin-like growth factor binding
GO:0008238	4.961e-02	1.999	8 AEBP1, CPZ, CTSA, DPP4, ERAP1, ERAP2, SCPEP1, TPP1	48	exopeptidase activity

Id	Pvalue	ExpCount	Count	Size	Term
04610	1.015e-05	1.734	12 A2M, BDKRB1, C1R, C1S, CD55, CFH, F10, F3, PLAUR, PROS1, TFPI, THBD	34	Complement and coagulation cascades
05332	7.002e-04	1.071	8 FAS, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, IL6	21	Graft-versus-host disease
04060	1.102e-03	6.221	19 BMPR2, CCL2, CSF1, FAS, IL11, IL15RA, IL1RAP, IL23A, IL6, IL6ST, IL8, LIF, LTBR, PDGFA, TNFRSF11B, TNFRSF14, TNFRSF1B, TNFSF4, VEGFA	122	Cytokine-cytokine receptor interaction
01032	1.351e-03	1.173	8 HEXA, IDS, IDUA, MAN2B1, MAN2B2, MANBA, NEU1, SGSH	23	Glycan structures - degradation
05330	5.298e-03	1.071	7 FAS, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G	21	Allograft rejection
05320	6.997e-03	1.122	7 FAS, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G	22	Autoimmune thyroid disease
00511	1.080e-02	0.5609	5 HEXA, MAN2B1, MAN2B2, MANBA, NEU1	11	N-Glycan degradation
04940	1.764e-02	1.326	7 FAS, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G	26	Type I diabetes mellitus

No enriched terms

No enriched terms

Entrez genes

A2Malpha-2-macroglobulin (217757_at), score: -0.23 ABLIM3actin binding LIM protein family, member 3 (205730_s_at), score: -0.29 ACSL1acyl-CoA synthetase long-chain family member 1 (201963_at), score: -0.24 ADIPOR2adiponectin receptor 2 (201346_at), score: -0.21 ADRA2Aadrenergic, alpha-2A-, receptor (209869_at), score: -0.39 AEBP1AE binding protein 1 (201792_at), score: -0.23 AJAP1adherens junctions associated protein 1 (206460_at), score: -0.36 ANGPTL4angiopoietin-like 4 (221009_s_at), score: -0.38 ANK2ankyrin 2, neuronal (202920_at), score: -0.19 ANKRD36ankyrin repeat domain 36 (214723_x_at), score: 0.63 ANO1anoctamin 1, calcium activated chloride channel (218804_at), score: -0.35 APODapolipoprotein D (201525_at), score: -0.21 ARID5AAT rich interactive domain 5A (MRF1-like) (213138_at), score: -0.27 ARMC9armadillo repeat containing 9 (219637_at), score: -0.23 ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (206414_s_at), score: -0.25 ATP13A3ATPase type 13A3 (219558_at), score: -0.24 B4GALT6UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 (206233_at), score: 0.66 BCANbrevican (91920_at), score: 0.62 BCL7AB-cell CLL/lymphoma 7A (203795_s_at), score: -0.24 BCORL1BCL6 co-repressor-like 1 (219444_at), score: 0.63 BDH23-hydroxybutyrate dehydrogenase, type 2 (218285_s_at), score: -0.2 BDKRB1bradykinin receptor B1 (207510_at), score: -0.2 BICC1bicaudal C homolog 1 (Drosophila) (220580_at), score: 0.62 BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase) (210214_s_at), score: -0.24 C11orf20chromosome 11 open reading frame 20 (219883_at), score: 0.66 C11orf21chromosome 11 open reading frame 21 (220560_at), score: 0.63 C17orf91chromosome 17 open reading frame 91 (214696_at), score: -0.26 C19orf28chromosome 19 open reading frame 28 (220178_at), score: -0.27 C1orf159chromosome 1 open reading frame 159 (219337_at), score: 0.64 C1Rcomplement component 1, r subcomponent (212067_s_at), score: -0.41 C1RLcomplement component 1, r subcomponent-like (218983_at), score: -0.19 C1Scomplement component 1, s subcomponent (208747_s_at), score: -0.29 C20orf27chromosome 20 open reading frame 27 (50314_i_at), score: 0.62 C9orf167chromosome 9 open reading frame 167 (219620_x_at), score: -0.28 C9orf33chromosome 9 open reading frame 33 (217130_at), score: 0.64 CADPS2Ca++-dependent secretion activator 2 (219572_at), score: -0.3 CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (211368_s_at), score: -0.28 CASP4caspase 4, apoptosis-related cysteine peptidase (209310_s_at), score: -0.29 CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b (209682_at), score: -0.25 CCBP2chemokine binding protein 2 (206887_at), score: 0.62 CCL2chemokine (C-C motif) ligand 2 (216598_s_at), score: -0.31 CCRL1chemokine (C-C motif) receptor-like 1 (220351_at), score: -0.35 CD302CD302 molecule (203799_at), score: -0.36 CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group) (201925_s_at), score: -0.28 CD58CD58 molecule (211744_s_at), score: -0.22 CD97CD97 molecule (202910_s_at), score: -0.26 CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae) (208022_s_at), score: -0.19 CDC42SE1CDC42 small effector 1 (218157_x_at), score: -0.3 CDH13cadherin 13, H-cadherin (heart) (204726_at), score: -0.24 CFHcomplement factor H (213800_at), score: -0.24 CFHR1complement factor H-related 1 (215388_s_at), score: -0.2 CHIC2cysteine-rich hydrophobic domain 2 (219492_at), score: -0.2 CLEC2BC-type lectin domain family 2, member B (209732_at), score: -0.33 CLEC7AC-type lectin domain family 7, member A (221698_s_at), score: 0.68 CLIP1CAP-GLY domain containing linker protein 1 (210716_s_at), score: -0.19 COL13A1collagen, type XIII, alpha 1 (211343_s_at), score: -0.22 COL14A1collagen, type XIV, alpha 1 (212865_s_at), score: -0.28 COL15A1collagen, type XV, alpha 1 (203477_at), score: -0.51 COL18A1collagen, type XVIII, alpha 1 (209081_s_at), score: -0.23 CORINcorin, serine peptidase (220356_at), score: -0.19 CPZcarboxypeptidase Z (211062_s_at), score: -0.3 CREG1cellular repressor of E1A-stimulated genes 1 (201200_at), score: -0.43 CRHR1corticotropin releasing hormone receptor 1 (208593_x_at), score: 0.64 CSF1colony stimulating factor 1 (macrophage) (209716_at), score: -0.3 CSGALNACT2chondroitin sulfate N-acetylgalactosaminyltransferase 2 (222235_s_at), score: -0.31 CST3cystatin C (201360_at), score: -0.33 CTSAcathepsin A (200661_at), score: -0.25 CTSOcathepsin O (203758_at), score: -0.24 CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1 (216607_s_at), score: -0.23 DCNdecorin (211896_s_at), score: -0.31 DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked (205000_at), score: -0.35 DENND3DENN/MADD domain containing 3 (212975_at), score: -0.24 DESdesmin (202222_s_at), score: 1 DGKDdiacylglycerol kinase, delta 130kDa (208072_s_at), score: -0.32 DHRS7dehydrogenase/reductase (SDR family) member 7 (210788_s_at), score: -0.19 DKK2dickkopf homolog 2 (Xenopus laevis) (219908_at), score: -0.41 DNAJC1DnaJ (Hsp40) homolog, subfamily C, member 1 (218409_s_at), score: -0.22 DNASE2deoxyribonuclease II, lysosomal (214992_s_at), score: -0.25 DOCK1dedicator of cytokinesis 1 (203187_at), score: -0.19 DOCK9dedicator of cytokinesis 9 (212538_at), score: -0.29 DPP4dipeptidyl-peptidase 4 (211478_s_at), score: -0.4 DPTdermatopontin (213068_at), score: -0.19 DSCR3Down syndrome critical region gene 3 (203635_at), score: -0.19 DUS2Ldihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae) (47105_at), score: 0.62 DUSP14dual specificity phosphatase 14 (203367_at), score: -0.22 DUSP3dual specificity phosphatase 3 (201537_s_at), score: -0.19 ECM1extracellular matrix protein 1 (209365_s_at), score: -0.39 EDN1endothelin 1 (218995_s_at), score: -0.25 EFHD1EF-hand domain family, member D1 (209343_at), score: -0.25 EGLN2egl nine homolog 2 (C. elegans) (220956_s_at), score: 0.62 EGR2early growth response 2 (Krox-20 homolog, Drosophila) (205249_at), score: -0.2 EGR3early growth response 3 (206115_at), score: -0.3 EIF1AYeukaryotic translation initiation factor 1A, Y-linked (204409_s_at), score: -0.26 EPHB3EPH receptor B3 (1438_at), score: 0.63 ERAP1endoplasmic reticulum aminopeptidase 1 (214012_at), score: -0.24 ERAP2endoplasmic reticulum aminopeptidase 2 (219759_at), score: -0.22 ESM1endothelial cell-specific molecule 1 (208394_x_at), score: -0.2 EXD3exonuclease 3'-5' domain containing 3 (220838_at), score: 0.68 F10coagulation factor X (205620_at), score: -0.35 F3coagulation factor III (thromboplastin, tissue factor) (204363_at), score: -0.33 FADS3fatty acid desaturase 3 (216080_s_at), score: -0.26 FASFas (TNF receptor superfamily, member 6) (216252_x_at), score: -0.19 FGF2fibroblast growth factor 2 (basic) (204421_s_at), score: -0.22 FGF5fibroblast growth factor 5 (210310_s_at), score: -0.22 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: -0.33 FHOD1formin homology 2 domain containing 1 (218530_at), score: -0.28 FLJ10404hypothetical protein FLJ10404 (218920_at), score: 0.62 FNDC3Afibronectin type III domain containing 3A (202304_at), score: -0.25 FOSBFBJ murine osteosarcoma viral oncogene homolog B (202768_at), score: -0.34 FURINfurin (paired basic amino acid cleaving enzyme) (201945_at), score: -0.2 GAAglucosidase, alpha; acid (202812_at), score: -0.23 GALNT3UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) (203397_s_at), score: -0.21 GAP43growth associated protein 43 (204471_at), score: 0.81 GDF11growth differentiation factor 11 (216860_s_at), score: 0.63 GEMGTP binding protein overexpressed in skeletal muscle (204472_at), score: -0.28 GLT8D2glycosyltransferase 8 domain containing 2 (221447_s_at), score: -0.22 GNALguanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type (206355_at), score: 0.67 GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (212959_s_at), score: -0.24 GPD1Lglycerol-3-phosphate dehydrogenase 1-like (212510_at), score: -0.21 GPLD1glycosylphosphatidylinositol specific phospholipase D1 (206264_at), score: 0.65 GPNMBglycoprotein (transmembrane) nmb (201141_at), score: -0.65 GPR183G protein-coupled receptor 183 (205419_at), score: -0.24 GPR37G protein-coupled receptor 37 (endothelin receptor type B-like) (209631_s_at), score: -0.28 GPX3glutathione peroxidase 3 (plasma) (214091_s_at), score: -0.33 GRAMD3GRAM domain containing 3 (218706_s_at), score: -0.24 GRIK2glutamate receptor, ionotropic, kainate 2 (213845_at), score: -0.23 GRNgranulin (211284_s_at), score: -0.35 GSTM1glutathione S-transferase mu 1 (204550_x_at), score: -0.2 GSTT1glutathione S-transferase theta 1 (203815_at), score: -0.24 HBEGFheparin-binding EGF-like growth factor (203821_at), score: -0.33 HEXAhexosaminidase A (alpha polypeptide) (201765_s_at), score: -0.2 HHEXhematopoietically expressed homeobox (215933_s_at), score: -0.29 HIST1H2AChistone cluster 1, H2ac (215071_s_at), score: -0.24 HIST1H2BKhistone cluster 1, H2bk (209806_at), score: -0.23 HIST1H4Ehistone cluster 1, H4e (206951_at), score: 0.67 HK2hexokinase 2 (202934_at), score: -0.39 HLA-Amajor histocompatibility complex, class I, A (217436_x_at), score: -0.35 HLA-Bmajor histocompatibility complex, class I, B (211911_x_at), score: -0.35 HLA-Cmajor histocompatibility complex, class I, C (211799_x_at), score: -0.45 HLA-Emajor histocompatibility complex, class I, E (200904_at), score: -0.47 HLA-Fmajor histocompatibility complex, class I, F (204806_x_at), score: -0.41 HLA-Gmajor histocompatibility complex, class I, G (211530_x_at), score: -0.21 HLXH2.0-like homeobox (214438_at), score: -0.21 HMGN1high-mobility group nucleosome binding domain 1 (200944_s_at), score: 0.65 HMOX1heme oxygenase (decycling) 1 (203665_at), score: -0.31 HOXB6homeobox B6 (205366_s_at), score: -0.28 HOXB7homeobox B7 (204779_s_at), score: -0.25 HPCAL1hippocalcin-like 1 (205462_s_at), score: -0.33 HSD17B11hydroxysteroid (17-beta) dehydrogenase 11 (217989_at), score: -0.2 HSPB7heat shock 27kDa protein family, member 7 (cardiovascular) (218934_s_at), score: -0.23 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (207135_at), score: -0.28 HTR2B5-hydroxytryptamine (serotonin) receptor 2B (206638_at), score: -0.31 HTRA1HtrA serine peptidase 1 (201185_at), score: -0.25 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: -0.25 IDI1isopentenyl-diphosphate delta isomerase 1 (204615_x_at), score: -0.27 IDSiduronate 2-sulfatase (202439_s_at), score: -0.21 IDUAiduronidase, alpha-L- (205059_s_at), score: -0.25 IFITM1interferon induced transmembrane protein 1 (9-27) (214022_s_at), score: -0.32 IGFBP5insulin-like growth factor binding protein 5 (203424_s_at), score: -0.23 IGFBP7insulin-like growth factor binding protein 7 (201162_at), score: -0.2 IL11interleukin 11 (206924_at), score: -0.22 IL15RAinterleukin 15 receptor, alpha (207375_s_at), score: -0.2 IL1RAPinterleukin 1 receptor accessory protein (205227_at), score: -0.34 IL1RL1interleukin 1 receptor-like 1 (207526_s_at), score: -0.4 IL23Ainterleukin 23, alpha subunit p19 (211796_s_at), score: -0.23 IL6interleukin 6 (interferon, beta 2) (205207_at), score: -0.48 IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor) (204864_s_at), score: -0.25 IL8interleukin 8 (202859_x_at), score: -0.3 INPP1inositol polyphosphate-1-phosphatase (202794_at), score: -0.22 ITFG1integrin alpha FG-GAP repeat containing 1 (221449_s_at), score: -0.19 ITGA1integrin, alpha 1 (214660_at), score: -0.25 ITIH2inter-alpha (globulin) inhibitor H2 (204987_at), score: 0.7 ITM2Bintegral membrane protein 2B (217732_s_at), score: -0.19 ITPR3inositol 1,4,5-triphosphate receptor, type 3 (201189_s_at), score: -0.29 JARID1Djumonji, AT rich interactive domain 1D (206700_s_at), score: -0.21 JARID2jumonji, AT rich interactive domain 2 (203297_s_at), score: -0.3 JHDM1Djumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (221778_at), score: -0.24 JMJD3jumonji domain containing 3, histone lysine demethylase (213146_at), score: -0.33 KANK1KN motif and ankyrin repeat domains 1 (213005_s_at), score: -0.23 KCNN4potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (204401_at), score: -0.25 KHDRBS3KH domain containing, RNA binding, signal transduction associated 3 (209781_s_at), score: -0.34 KIAA0247KIAA0247 (202181_at), score: -0.25 KIAA1644KIAA1644 (52837_at), score: -0.24 KLHL21kelch-like 21 (Drosophila) (203068_at), score: -0.27 KLHL26kelch-like 26 (Drosophila) (219354_at), score: -0.28 LBHlimb bud and heart development homolog (mouse) (221011_s_at), score: -0.2 LEPROTleptin receptor overlapping transcript (202378_s_at), score: -0.24 LGALS3BPlectin, galactoside-binding, soluble, 3 binding protein (200923_at), score: -0.25 LGR4leucine-rich repeat-containing G protein-coupled receptor 4 (218326_s_at), score: 0.68 LHFPlipoma HMGIC fusion partner (218656_s_at), score: -0.39 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: -0.25 LITAFlipopolysaccharide-induced TNF factor (200706_s_at), score: -0.22 LMBRD1LMBR1 domain containing 1 (218191_s_at), score: -0.42 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: -0.34 LOC100128809similar to hCG2045829 (215707_s_at), score: -0.24 LOC286434hypothetical protein LOC286434 (222196_at), score: 0.66 LOC730227hypothetical protein LOC730227 (215756_at), score: 0.64 LRIG1leucine-rich repeats and immunoglobulin-like domains 1 (211596_s_at), score: -0.22 LTBRlymphotoxin beta receptor (TNFR superfamily, member 3) (203005_at), score: -0.19 LY96lymphocyte antigen 96 (206584_at), score: -0.39 LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog (202625_at), score: -0.24 MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) (209348_s_at), score: -0.27 MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2 (209737_at), score: -0.27 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: -0.4 MAN2B1mannosidase, alpha, class 2B, member 1 (209166_s_at), score: -0.33 MAN2B2mannosidase, alpha, class 2B, member 2 (214703_s_at), score: -0.23 MANBAmannosidase, beta A, lysosomal (203778_at), score: -0.21 MAP1Smicrotubule-associated protein 1S (218522_s_at), score: -0.21 MAP3K4mitogen-activated protein kinase kinase kinase 4 (216199_s_at), score: -0.21 MAP3K7IP2mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (210284_s_at), score: -0.23 MAXMYC associated factor X (210734_x_at), score: -0.19 MEGF9multiple EGF-like-domains 9 (212830_at), score: -0.19 MEIS1Meis homeobox 1 (204069_at), score: -0.27 MEIS3P1Meis homeobox 3 pseudogene 1 (214077_x_at), score: -0.33 MEOX1mesenchyme homeobox 1 (205619_s_at), score: 0.68 MFAP4microfibrillar-associated protein 4 (212713_at), score: -0.32 MKS1Meckel syndrome, type 1 (218630_at), score: 0.65 MTSS1metastasis suppressor 1 (203037_s_at), score: -0.32 MUC3Amucin 3A, cell surface associated (217117_x_at), score: 0.63 MYO1Dmyosin ID (212338_at), score: -0.32 NACAP1nascent-polypeptide-associated complex alpha polypeptide pseudogene 1 (211445_x_at), score: 0.65 NAMPTnicotinamide phosphoribosyltransferase (217738_at), score: -0.35 NEU1sialidase 1 (lysosomal sialidase) (208926_at), score: -0.2 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: -0.42 NFIL3nuclear factor, interleukin 3 regulated (203574_at), score: -0.29 NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: -0.43 NID1nidogen 1 (202008_s_at), score: -0.31 NINJ1ninjurin 1 (203045_at), score: -0.34 NLGN4Xneuroligin 4, X-linked (221933_at), score: 0.73 NOVA1neuro-oncological ventral antigen 1 (205794_s_at), score: 0.67 NPnucleoside phosphorylase (201695_s_at), score: -0.25 NPC1Niemann-Pick disease, type C1 (202679_at), score: -0.35 NPC2Niemann-Pick disease, type C2 (200701_at), score: -0.43 NPTX1neuronal pentraxin I (204684_at), score: -0.22 NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (201866_s_at), score: -0.23 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: -0.39 NRXN3neurexin 3 (205795_at), score: -0.19 NT5DC25'-nucleotidase domain containing 2 (218051_s_at), score: 0.64 OLFML2Aolfactomedin-like 2A (213075_at), score: -0.32 OR10C1olfactory receptor, family 10, subfamily C, member 1 (221339_at), score: 0.63 OS9osteosarcoma amplified 9, endoplasmic reticulum associated protein (200714_x_at), score: -0.22 OSTM1osteopetrosis associated transmembrane protein 1 (218196_at), score: -0.3 P2RX4purinergic receptor P2X, ligand-gated ion channel, 4 (204088_at), score: -0.19 PCDH7protocadherin 7 (205534_at), score: -0.23 PDGFAplatelet-derived growth factor alpha polypeptide (205463_s_at), score: -0.33 PDGFDplatelet derived growth factor D (219304_s_at), score: -0.29 PDLIM3PDZ and LIM domain 3 (209621_s_at), score: -0.27 PEG3paternally expressed 3 (209242_at), score: 0.64 PIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide (203879_at), score: -0.26 PIONpigeon homolog (Drosophila) (222150_s_at), score: -0.23 PKNOX2PBX/knotted 1 homeobox 2 (63305_at), score: 0.62 PKP2plakophilin 2 (207717_s_at), score: -0.36 PLAURplasminogen activator, urokinase receptor (211924_s_at), score: -0.22 PLSCR4phospholipid scramblase 4 (218901_at), score: -0.24 PMAIP1phorbol-12-myristate-13-acetate-induced protein 1 (204286_s_at), score: -0.2 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: -0.46 POLR1Cpolymerase (RNA) I polypeptide C, 30kDa (207515_s_at), score: -0.22 PPAP2Aphosphatidic acid phosphatase type 2A (209147_s_at), score: -0.33 PPARDperoxisome proliferator-activated receptor delta (37152_at), score: -0.39 PROS1protein S (alpha) (207808_s_at), score: -0.23 PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (209040_s_at), score: -0.25 PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) (204279_at), score: -0.22 PTGDSprostaglandin D2 synthase 21kDa (brain) (212187_x_at), score: -0.4 RALGPS2Ral GEF with PH domain and SH3 binding motif 2 (220338_at), score: 0.62 RAMP1receptor (G protein-coupled) activity modifying protein 1 (204916_at), score: -0.19 RAPGEF2Rap guanine nucleotide exchange factor (GEF) 2 (203097_s_at), score: -0.34 RCAN2regulator of calcineurin 2 (203498_at), score: -0.42 RCL1RNA terminal phosphate cyclase-like 1 (218544_s_at), score: -0.25 RGS2regulator of G-protein signaling 2, 24kDa (202388_at), score: -0.25 RGS3regulator of G-protein signaling 3 (203823_at), score: -0.29 RNASET2ribonuclease T2 (217983_s_at), score: -0.2 RPL7P24ribosomal protein L7 pseudogene 24 (217092_x_at), score: 0.67 RPS28P6ribosomal protein S28 pseudogene 6 (216380_x_at), score: -0.19 RPS4Y1ribosomal protein S4, Y-linked 1 (201909_at), score: -0.43 RRADRas-related associated with diabetes (204803_s_at), score: -0.52 RUNX1runt-related transcription factor 1 (209360_s_at), score: -0.31 SAT1spermidine/spermine N1-acetyltransferase 1 (213988_s_at), score: -0.26 SCARB1scavenger receptor class B, member 1 (201819_at), score: -0.27 SCARB2scavenger receptor class B, member 2 (201647_s_at), score: -0.24 SCML2sex comb on midleg-like 2 (Drosophila) (206147_x_at), score: -0.21 SCPEP1serine carboxypeptidase 1 (218217_at), score: -0.3 SECTM1secreted and transmembrane 1 (213716_s_at), score: -0.27 SEMA4Gsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G (219194_at), score: 0.63 SEMA5Asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A (205405_at), score: -0.22 SEPP1selenoprotein P, plasma, 1 (201427_s_at), score: -0.2 SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 2 (204614_at), score: -0.29 SETD3SET domain containing 3 (212465_at), score: -0.22 SETXsenataxin (201964_at), score: -0.2 SFRP1secreted frizzled-related protein 1 (202036_s_at), score: -0.19 SFRS5splicing factor, arginine/serine-rich 5 (212266_s_at), score: -0.24 SGCEsarcoglycan, epsilon (204688_at), score: -0.19 SGSHN-sulfoglucosamine sulfohydrolase (35626_at), score: -0.24 SH3BGRLSH3 domain binding glutamic acid-rich protein like (201311_s_at), score: -0.22 SHBSrc homology 2 domain containing adaptor protein B (204657_s_at), score: -0.26 SIX1SIX homeobox 1 (205817_at), score: 0.63 SLC10A3solute carrier family 10 (sodium/bile acid cotransporter family), member 3 (204928_s_at), score: -0.22 SLC16A4solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (205234_at), score: -0.19 SLC17A9solute carrier family 17, member 9 (219559_at), score: -0.2 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: -0.29 SLC1A1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 (213664_at), score: -0.21 SLC20A2solute carrier family 20 (phosphate transporter), member 2 (202744_at), score: -0.21 SLC22A18solute carrier family 22, member 18 (204981_at), score: -0.2 SLC2A10solute carrier family 2 (facilitated glucose transporter), member 10 (221024_s_at), score: -0.24 SLC39A8solute carrier family 39 (zinc transporter), member 8 (209267_s_at), score: -0.26 SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 (209830_s_at), score: -0.19 SLCO3A1solute carrier organic anion transporter family, member 3A1 (219229_at), score: -0.28 SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 (201074_at), score: 0.62 SMOXspermine oxidase (210357_s_at), score: -0.22 SOCS2suppressor of cytokine signaling 2 (203373_at), score: -0.25 SOD3superoxide dismutase 3, extracellular (205236_x_at), score: -0.3 SOX11SRY (sex determining region Y)-box 11 (204914_s_at), score: 0.71 SOX4SRY (sex determining region Y)-box 4 (201417_at), score: -0.26 SPATA20spermatogenesis associated 20 (218164_at), score: -0.2 SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: -0.27 SPRY2sprouty homolog 2 (Drosophila) (204011_at), score: -0.27 SPRY4sprouty homolog 4 (Drosophila) (221489_s_at), score: -0.33 SQRDLsulfide quinone reductase-like (yeast) (217995_at), score: -0.28 SRFserum response factor (c-fos serum response element-binding transcription factor) (202401_s_at), score: -0.2 STARD13StAR-related lipid transfer (START) domain containing 13 (213103_at), score: -0.22 STBD1starch binding domain 1 (203986_at), score: -0.2 STK38Lserine/threonine kinase 38 like (212572_at), score: -0.31 STOMstomatin (201060_x_at), score: -0.31 STXBP5Lsyntaxin binding protein 5-like (215518_at), score: 0.64 SULF1sulfatase 1 (212353_at), score: -0.26 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: -0.36 TAC3tachykinin 3 (219992_at), score: 0.63 TAPBPLTAP binding protein-like (218746_at), score: -0.19 TBX3T-box 3 (219682_s_at), score: -0.31 TCOF1Treacher Collins-Franceschetti syndrome 1 (202385_s_at), score: 0.62 TCTN1tectonic family member 1 (218584_at), score: -0.23 TEX2testis expressed 2 (218099_at), score: -0.29 TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) (209676_at), score: -0.2 THBDthrombomodulin (203887_s_at), score: -0.24 TM2D1TM2 domain containing 1 (211703_s_at), score: -0.42 TM6SF1transmembrane 6 superfamily member 1 (219892_at), score: -0.3 TMBIM4transmembrane BAX inhibitor motif containing 4 (219206_x_at), score: -0.27 TMEM158transmembrane protein 158 (213338_at), score: -0.2 TMEM39Atransmembrane protein 39A (218615_s_at), score: -0.23 TMEM41Btransmembrane protein 41B (212623_at), score: -0.42 TMEM51transmembrane protein 51 (218815_s_at), score: -0.21 TNFAIP2tumor necrosis factor, alpha-induced protein 2 (202510_s_at), score: -0.4 TNFAIP8tumor necrosis factor, alpha-induced protein 8 (210260_s_at), score: -0.21 TNFRSF11Btumor necrosis factor receptor superfamily, member 11b (204933_s_at), score: -0.39 TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) (209354_at), score: -0.2 TNFRSF1Btumor necrosis factor receptor superfamily, member 1B (203508_at), score: -0.25 TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (207426_s_at), score: -0.32 TNS3tensin 3 (217853_at), score: -0.32 TNXBtenascin XB (216333_x_at), score: -0.2 TOM1target of myb1 (chicken) (202807_s_at), score: -0.23 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: -0.31 TP53I11tumor protein p53 inducible protein 11 (214667_s_at), score: -0.29 TPD52tumor protein D52 (201690_s_at), score: -0.23 TPP1tripeptidyl peptidase I (200742_s_at), score: -0.47 TPST1tyrosylprotein sulfotransferase 1 (204140_at), score: -0.35 TPST2tyrosylprotein sulfotransferase 2 (204079_at), score: -0.25 TRAF1TNF receptor-associated factor 1 (205599_at), score: -0.19 TRAF3TNF receptor-associated factor 3 (221571_at), score: -0.25 TRAF3IP2TRAF3 interacting protein 2 (215411_s_at), score: -0.25 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: -0.35 TRIM22tripartite motif-containing 22 (213293_s_at), score: -0.3 TTPALtocopherol (alpha) transfer protein-like (219633_at), score: -0.19 UBA7ubiquitin-like modifier activating enzyme 7 (203281_s_at), score: -0.21 UBE3Bubiquitin protein ligase E3B (212403_at), score: -0.22 USP22ubiquitin specific peptidase 22 (200083_at), score: 0.67 UTP3UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) (209486_at), score: -0.22 VEGFAvascular endothelial growth factor A (211527_x_at), score: -0.29 WDR3WD repeat domain 3 (218882_s_at), score: -0.21 WISP2WNT1 inducible signaling pathway protein 2 (205792_at), score: -0.31 WT1Wilms tumor 1 (206067_s_at), score: -0.2 WTAPWilms tumor 1 associated protein (210285_x_at), score: -0.29 YIPF6Yip1 domain family, member 6 (212341_at), score: -0.2 YRDCyrdC domain containing (E. coli) (218647_s_at), score: -0.27 ZBTB20zinc finger and BTB domain containing 20 (205383_s_at), score: -0.2 ZKSCAN3zinc finger with KRAB and SCAN domains 3 (211773_s_at), score: 0.67 ZMYM6zinc finger, MYM-type 6 (219924_s_at), score: -0.27 ZNF143zinc finger protein 143 (221873_at), score: -0.21 ZNF35zinc finger protein 35 (206096_at), score: -0.26 ZNF672zinc finger protein 672 (218068_s_at), score: -0.27

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
46A.CEL	1	3	DS-mosaic	hgu133plus2	none	DS-mosaic 1
t21b 08-03.CEL	5	1	DS-CC	hgu133a	Down	DS-CC 5
t21c 08-03.CEL	6	1	DS-CC	hgu133a	Down	DS-CC 6
t21d 08-03.CEL	7	1	DS-CC	hgu133a	Down	DS-CC 7
5CTwin.CEL	5	2	DS-twin	hgu133plus2	Down	DS-twin 5
2Twin.CEL	2	2	DS-twin	hgu133plus2	none	DS-twin 2
6Twin.CEL	6	2	DS-twin	hgu133plus2	none	DS-twin 6
1Twin.CEL	1	2	DS-twin	hgu133plus2	Down	DS-twin 1