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DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

chromosome segregation

The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.

chromosome organization

A process that is carried out at the cellular level that results in the formation, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information.

mitotic sister chromatid segregation

The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.

cell cycle checkpoint

The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.

DNA replication checkpoint

A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

mitotic cell cycle

Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.

M phase

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.

nuclear division

A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.

double-strand break repair via homologous recombination

The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.

recombinational repair

The repair of damaged DNA that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA.

DNA synthesis during DNA repair

Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

cellular alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

DNA-dependent DNA replication

The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

DNA replication initiation

The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

nucleotide-excision repair

In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).

nucleotide-excision repair, DNA gap filling

Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes.

double-strand break repair

The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

DNA recombination

Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

DNA packaging

Any process by which DNA and associated proteins are formed into a compact, orderly structure.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

cholesterol biosynthetic process

The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

response to DNA damage stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

organelle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

microtubule-based process

Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.

microtubule-based movement

Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

spindle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

mitotic chromosome condensation

The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

meiosis

A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiotic division occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

intracellular signaling cascade

A series of reactions within the cell that occur as a result of a single trigger reaction or compound.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

negative regulation of biosynthetic process

Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of macromolecule biosynthetic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cell cycle process

Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cellular component organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cellular component.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

second-messenger-mediated signaling

A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell.

phosphoinositide-mediated signaling

A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

regulation of DNA replication initiation

Any process that modulates the frequency, rate or extent of initiation of DNA replication; the process by which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.

chromosome condensation

The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

cytoskeleton-dependent intracellular transport

The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

negative regulation of cellular biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

DNA integrity checkpoint

Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure.

negative regulation of DNA replication initiation

Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular response to DNA damage stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

intracellular transport

The directed movement of substances within a cell.

organelle fission

The creation of two or more organelles by division of one organelle.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of DNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cell division

The process resulting in the physical partitioning and separation of a cell into daughter cells.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

meiotic cell cycle

Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell.

interphase

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

M phase of meiotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the meiotic cell cycle during which meiosis takes place.

interphase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

all

This term is the most general term possible

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biosynthetic process

Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.

regulation of biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

intracellular transport

The directed movement of substances within a cell.

negative regulation of biosynthetic process

Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of macromolecule biosynthetic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

negative regulation of cellular biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

negative regulation of macromolecule biosynthetic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of cellular biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

regulation of macromolecule biosynthetic process

Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

regulation of cell cycle process

Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cellular response to DNA damage stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

negative regulation of macromolecule biosynthetic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

negative regulation of cellular biosynthetic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

regulation of DNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

regulation of DNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

mitotic chromosome condensation

The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

meiosis

A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiotic division occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations.

mitotic chromosome condensation

The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

chromosome condensation

The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

spindle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

M phase of meiotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the meiotic cell cycle during which meiosis takes place.

mitotic sister chromatid segregation

The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

interphase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

microtubule-based movement

Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

cholesterol biosynthetic process

The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

regulation of DNA replication

Any process that modulates the frequency, rate or extent of DNA replication.

negative regulation of DNA replication

Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication.

regulation of DNA replication initiation

Any process that modulates the frequency, rate or extent of initiation of DNA replication; the process by which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.

negative regulation of DNA replication initiation

Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication.

DNA synthesis during DNA repair

Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template.

recombinational repair

The repair of damaged DNA that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

negative regulation of DNA replication initiation

Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication.

DNA replication checkpoint

A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.

DNA replication initiation

The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

nucleotide-excision repair, DNA gap filling

Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes.

double-strand break repair via homologous recombination

The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

condensed nuclear chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus.

condensed chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosome, centromeric region

The region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

replication fork

The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

alpha DNA polymerase:primase complex

A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.

chromosome

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

microtubule organizing center

A region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

membrane-enclosed lumen

The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

protein-DNA complex

A macromolecular complex containing both protein and DNA molecules.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

all

This term is the most general term possible

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

microtubule organizing center

A region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow.

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

alpha DNA polymerase:primase complex

A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

alpha DNA polymerase:primase complex

A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.

nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

condensed nuclear chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

microtubule organizing center

A region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nucleotide binding

Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

nucleic acid binding

Interacting selectively with any nucleic acid.

DNA binding

Interacting selectively with DNA (deoxyribonucleic acid).

ATPase activity, coupled

Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane.

motor activity

Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate.

microtubule motor activity

Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

nucleoside-triphosphatase activity

Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.

nuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids.

exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

ATP binding

Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

DNA-dependent ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction.

ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction.

pyrophosphatase activity

Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

hydrolase activity, acting on ester bonds

Catalysis of the hydrolysis of any ester bond.

hydrolase activity, acting on acid anhydrides

Catalysis of the hydrolysis of any acid anhydride.

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.

purine nucleotide binding

Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate.

adenyl nucleotide binding

Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.

ribonucleotide binding

Interacting selectively with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

purine ribonucleotide binding

Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

adenyl ribonucleotide binding

Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

all

This term is the most general term possible

purine ribonucleotide binding

Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

adenyl ribonucleotide binding

Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022403	2.668e-42	19.71	99 ASPM, AURKA, AURKB, BIRC5, BLM, BRCA2, BUB1, BUB1B, C13orf34, C14orf106, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNE1, CCNF, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN2D, CDKN3, CDT1, CENPE, CENPF, CEP55, CHEK1, CIT, DBF4, DDX11, DLGAP5, DMC1, DSN1, ERCC6L, ESPL1, EXO1, FAM29A, FBXO5, GTSE1, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIFC1, KNTC1, MAD2L1, MPHOSPH9, MRE11A, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKIA, PKMYT1, PLK1, POLA1, POLD1, POLE, PRC1, PSMC3IP, PTTG1, RAD51, RAD51L1, RAD54B, RAD54L, SMC2, SMC4, SPAG5, SPC25, STMN1, TACC3, TIMELESS, TIPIN, TPD52L1, TPX2, TTK, UBE2C, WEE1, ZWILCH, ZWINT	287	cell cycle phase
GO:0000279	2.823e-39	15.86	86 ASPM, AURKA, AURKB, BIRC5, BRCA2, BUB1, BUB1B, C13orf34, C14orf106, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, CHEK1, CIT, DDX11, DLGAP5, DMC1, DSN1, ERCC6L, ESPL1, EXO1, FAM29A, FBXO5, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIFC1, KNTC1, MAD2L1, MPHOSPH9, MRE11A, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PRC1, PSMC3IP, PTTG1, RAD51, RAD51L1, RAD54B, RAD54L, SMC2, SMC4, SPAG5, SPC25, STMN1, TACC3, TIMELESS, TIPIN, TPX2, TTK, UBE2C, WEE1, ZWILCH, ZWINT	231	M phase
GO:0000087	1.781e-35	12.15	72 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C13orf34, C14orf106, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, CIT, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, FAM29A, FBXO5, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIFC1, KNTC1, MAD2L1, MPHOSPH9, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PTTG1, SMC2, SMC4, SPAG5, SPC25, TIMELESS, TIPIN, TPX2, UBE2C, WEE1, ZWILCH, ZWINT	177	M phase of mitotic cell cycle
GO:0000280	4.579e-35	11.95	71 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C13orf34, C14orf106, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, CIT, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, FAM29A, FBXO5, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIFC1, KNTC1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PTTG1, SMC2, SMC4, SPAG5, SPC25, TIMELESS, TIPIN, TPX2, UBE2C, WEE1, ZWILCH, ZWINT	174	nuclear division
GO:0007067	4.579e-35	11.95	71 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C13orf34, C14orf106, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, CIT, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, FAM29A, FBXO5, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIFC1, KNTC1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PTTG1, SMC2, SMC4, SPAG5, SPC25, TIMELESS, TIPIN, TPX2, UBE2C, WEE1, ZWILCH, ZWINT	174	mitosis
GO:0022402	1.895e-34	27.12	106 ASPM, AURKA, AURKB, BARD1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C13orf34, C14orf106, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNE1, CCNF, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN2D, CDKN3, CDT1, CENPE, CENPF, CEP55, CHEK1, CIT, CP110, DBF4, DDX11, DHCR24, DLGAP5, DMC1, DSN1, ERCC6L, ESPL1, EXO1, FAM29A, FBXO5, GTSE1, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIFC1, KNTC1, MAD2L1, MPHOSPH9, MRE11A, MSH2, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKIA, PKMYT1, PLK1, POLA1, POLD1, POLE, PRC1, PSMC3IP, PTTG1, RACGAP1, RAD51, RAD51L1, RAD54B, RAD54L, SMC2, SMC4, SPAG5, SPC25, STMN1, TACC3, TIMELESS, TIPIN, TPD52L1, TPX2, TTK, UBE2C, WEE1, ZWILCH, ZWINT	395	cell cycle process
GO:0048285	6.283e-34	12.36	71 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C13orf34, C14orf106, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, CIT, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, FAM29A, FBXO5, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIFC1, KNTC1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PTTG1, SMC2, SMC4, SPAG5, SPC25, TIMELESS, TIPIN, TPX2, UBE2C, WEE1, ZWILCH, ZWINT	180	organelle fission
GO:0007049	8.124e-34	44.77	138 ASPM, AURKA, AURKB, BARD1, BIRC5, BLM, BMP2, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, C13orf15, C13orf34, C14orf106, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CCNF, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN2D, CDKN3, CDT1, CENPE, CENPF, CEP55, CHAF1A, CHAF1B, CHEK1, CIT, CKAP2, CKS1B, CP110, DBF4, DDX11, DDX12, DHCR24, DLGAP5, DMC1, DSCC1, DSN1, DTYMK, E2F8, ERCC6L, ESPL1, EXO1, FAM29A, FANCG, FANCI, FBXO5, GMNN, GTSE1, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIFC1, KNTC1, LIG1, MAD2L1, MAP3K8, MCM2, MCM3, MCM7, MDC1, MKI67, MPHOSPH9, MRE11A, MSH2, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NPAT, NUSAP1, OIP5, PBK, PKIA, PKMYT1, PLK1, POLA1, POLD1, POLE, PRC1, PSMC3IP, PSRC1, PTTG1, RACGAP1, RAD51, RAD51L1, RAD54B, RAD54L, RAD9A, RBL1, SMC2, SMC4, SPAG5, SPC25, STMN1, SUV39H1, TACC3, TFDP1, TIMELESS, TIPIN, TP53BP2, TPD52L1, TPX2, TTK, TXNIP, UBE2C, WEE1, XAF1, ZWILCH, ZWINT	652	cell cycle
GO:0000278	8.205e-32	21.63	91 ASPM, AURKA, AURKB, BIRC5, BLM, BRCA2, BUB1, BUB1B, C13orf34, C14orf106, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNE1, CCNF, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN2D, CDKN3, CDT1, CENPE, CENPF, CEP55, CHEK1, CIT, DBF4, DDX11, DLGAP5, DSN1, ERCC6L, ESPL1, FAM29A, FBXO5, GTSE1, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIFC1, KNTC1, MAD2L1, MPHOSPH9, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PBK, PKIA, PKMYT1, PLK1, POLA1, POLD1, POLE, PRC1, PTTG1, SMC2, SMC4, SPAG5, SPC25, STMN1, TIMELESS, TIPIN, TPD52L1, TPX2, TTK, UBE2C, WEE1, ZWILCH, ZWINT	315	mitotic cell cycle
GO:0051301	1.167e-31	13.25	71 ASPM, AURKB, BLM, BRCA2, BUB1, BUB1B, C13orf34, C14orf106, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CCNF, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC6, CDC7, CDCA3, CDCA8, CDK2, CENPE, CENPF, CENPJ, CENPO, CEP55, CIT, CKS1B, CP110, DSN1, ERCC6L, ESPL1, FAM29A, FBXO5, HELLS, KIF11, KIF20B, KIF23, KIFC1, KNTC1, LIG1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NUSAP1, OIP5, PLK1, PRC1, PTTG1, RACGAP1, SMC2, SMC4, SPAG5, SPC25, TIMELESS, TIPIN, UBE2C, WEE1, ZWILCH, ZWINT	193	cell division
GO:0006260	7.272e-22	12.43	58 BLM, BRCA1, BRCA2, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDKN2D, CDT1, CHAF1A, CHAF1B, CHEK1, DBF4, DNA2, DSCC1, DTL, EXO1, FEN1, GINS1, GINS2, GINS3, GINS4, GMNN, HMGB2, LIG1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MRE11A, MSH2, ORC1L, ORC6L, PDGFA, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, RAD51, RAD9A, RFC2, RFC3, RFC4, RMI1, RNASEH2A, RPA2, SUPT16H, TIPIN, TK1, TOP2A	181	DNA replication
GO:0006259	1.545e-19	25.68	82 BLM, BRCA1, BRCA2, BRIP1, BTG2, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDKN2D, CDT1, CHAF1A, CHAF1B, CHEK1, DBF4, DCLRE1B, DCLRE1C, DMC1, DNA2, DSCC1, DTL, EXO1, FANCA, FANCG, FANCI, FEN1, GINS1, GINS2, GINS3, GINS4, GMNN, HELLS, HMGB2, IL7R, LIG1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDC1, MRE11A, MSH2, MYC, NEIL3, ORC1L, ORC6L, PARP2, PDGFA, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, PSMC3IP, PTTG1, PTTG3, RAD51, RAD51AP1, RAD51L1, RAD54B, RAD54L, RAD9A, RFC2, RFC3, RFC4, RMI1, RNASEH2A, RPA2, SUPT16H, TDP1, TIPIN, TK1, TOP2A, TOPBP1, UNG	374	DNA metabolic process
GO:0006996	7.253e-13	61.53	124 ARHGAP26, ARHGAP6, ASF1B, ASPM, AURKA, AURKB, BBS1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C13orf34, C14orf106, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CDYL, CENPA, CENPE, CENPF, CENPJ, CEP55, CHAF1A, CHAF1B, CIT, CP110, CPA4, DAAM2, DDX11, DIS3, DLGAP5, DSN1, ERCC6L, ESPL1, EXOSC9, EZH2, FAM29A, FANCG, FBXO5, FHL3, GOLGB1, HELLS, HIRIP3, HIST1H1C, HMGB2, IL1A, IL1B, JARID1B, JMJD3, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, KNTC1, MAD2L1, MCM2, MRE11A, MSH2, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD9, NEK2, NR3C1, NUSAP1, OIP5, OPTN, PBK, PDGFA, PKMYT1, PLK1, PRC1, PRKG1, PSRC1, PTTG1, PTTG3, RACGAP1, RAD54L, RBL1, RSL24D1, SMC2, SMC4, SPAG5, SPC25, STMN1, STX6, SUPT16H, SUV39H1, TACC3, TIMELESS, TIPIN, TMEM48, TOP2A, TPX2, TTK, TUBGCP5, UBE2C, WEE1, WHSC1, WNT2, ZWILCH, ZWINT	896	organelle organization
GO:0006974	6.743e-11	18.13	54 ATAD5, BARD1, BLM, BRCA1, BRCA2, BRIP1, BTG2, CCNA2, CDKN2D, CHAF1A, CHAF1B, CHEK1, DCLRE1B, DCLRE1C, DTL, EXO1, FANCA, FANCG, FANCI, FEN1, GTSE1, HMGB2, LIG1, MCM7, MDC1, MRE11A, MSH2, NEIL3, NUPR1, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51, RAD51AP1, RAD51L1, RAD54B, RAD54L, RAD9A, RFC2, RFC3, RFC4, RPA2, SUPT16H, TDP1, TIMELESS, TIPIN, TOP2A, TOPBP1, UNG	264	response to DNA damage stimulus
GO:0007059	1.814e-10	3.159	21 BRCA1, CENPE, CENPF, CENPO, DDX11, DLGAP5, DSN1, ESPL1, KIFC1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1, PTTG1, SMC2, SMC4, TOP2A, ZWINT	46	chromosome segregation
GO:0034984	4.292e-10	16.14	49 BLM, BRCA1, BRCA2, BRIP1, BTG2, CCNA2, CDKN2D, CHAF1A, CHAF1B, CHEK1, DCLRE1B, DCLRE1C, EXO1, FANCA, FANCG, FANCI, FEN1, GTSE1, HMGB2, LIG1, MDC1, MRE11A, MSH2, NEIL3, NUPR1, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51, RAD51AP1, RAD51L1, RAD54B, RAD54L, RAD9A, RFC2, RFC3, RFC4, RPA2, SUPT16H, TDP1, TIPIN, TOP2A, TOPBP1, UNG	235	cellular response to DNA damage stimulus
GO:0000070	4.317e-10	1.579	15 CENPE, DDX11, DLGAP5, ESPL1, KIFC1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1, SMC2, SMC4, ZWINT	23	mitotic sister chromatid segregation
GO:0006281	4.836e-10	14.01	45 BLM, BRCA1, BRCA2, BRIP1, BTG2, CDKN2D, CHAF1A, CHAF1B, CHEK1, DCLRE1B, DCLRE1C, EXO1, FANCA, FANCG, FANCI, FEN1, HMGB2, LIG1, MDC1, MRE11A, MSH2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51, RAD51AP1, RAD51L1, RAD54B, RAD54L, RAD9A, RFC2, RFC3, RFC4, RPA2, SUPT16H, TDP1, TOP2A, TOPBP1, UNG	204	DNA repair
GO:0000819	1.030e-09	1.648	15 CENPE, DDX11, DLGAP5, ESPL1, KIFC1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1, SMC2, SMC4, ZWINT	24	sister chromatid segregation
GO:0007017	1.279e-09	9.27	35 AURKA, BBS1, BRCA1, BRCA2, BUB1B, CENPE, CENPJ, CP110, ESPL1, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, NDC80, NEK2, NUSAP1, PRC1, PSRC1, SPAG5, STMN1, TACC3, TTK, TUBGCP5, UBE2C, WNT2, ZWINT	135	microtubule-based process
GO:0007346	7.358e-09	6.111	27 BLM, BRCA2, BUB1, BUB1B, CCNA2, CDC25C, CDC6, CDK2, CDT1, CENPF, DLGAP5, ESPL1, GTSE1, IL1A, IL1B, KIF20B, KNTC1, MAD2L1, MYC, NEK2, NUSAP1, PKIA, PKMYT1, TTK, UBE2C, ZWILCH, ZWINT	89	regulation of mitotic cell cycle
GO:0000075	9.641e-09	3.777	21 BLM, BRIP1, BUB1, BUB1B, CCNA2, CCNE2, CDC45L, CDC6, CDT1, CENPF, CHEK1, FANCG, GTSE1, KNTC1, MAD2L1, MSH2, RAD9A, TIPIN, TTK, ZWILCH, ZWINT	55	cell cycle checkpoint
GO:0006261	1.192e-08	4.189	22 CDC45L, CDC6, CDT1, EXO1, HMGB2, MCM2, MCM3, MCM4, MCM5, MCM7, MSH2, ORC1L, POLA1, POLD3, POLE2, PRIM1, RAD51, RAD9A, RFC3, RFC4, RPA2, TIPIN	61	DNA-dependent DNA replication
GO:0051726	2.196e-08	17.99	49 BLM, BMP2, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, C13orf15, CCNA2, CCNE2, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDKN2D, CDKN3, CDT1, CENPF, CHEK1, CKS1B, DLGAP5, ESPL1, FANCG, GMNN, GTSE1, IL1A, IL1B, KIF20B, KNTC1, MAD2L1, MSH2, MYC, NEK2, NUSAP1, PKIA, PKMYT1, RAD9A, RBL1, TACC3, TIMELESS, TIPIN, TP53BP2, TTK, UBE2C, XAF1, ZWILCH, ZWINT	262	regulation of cell cycle
GO:0000226	4.670e-08	5.287	24 AURKA, BBS1, BRCA1, BRCA2, BUB1B, CENPJ, CP110, ESPL1, KIF11, KIF23, KIF2C, NDC80, NEK2, NUSAP1, PRC1, PSRC1, SPAG5, STMN1, TACC3, TTK, TUBGCP5, UBE2C, WNT2, ZWINT	77	microtubule cytoskeleton organization
GO:0006270	2.464e-07	1.373	12 CDC45L, CDC6, CDT1, MCM2, MCM3, MCM4, MCM5, MCM7, ORC1L, POLA1, RAD9A, TIPIN	20	DNA replication initiation
GO:0033554	4.874e-07	22.25	53 BLM, BRCA1, BRCA2, BRIP1, BTG2, CCNA2, CDKN2D, CHAF1A, CHAF1B, CHEK1, DCLRE1B, DCLRE1C, EXO1, FADS1, FANCA, FANCG, FANCI, FEN1, GTSE1, HMGB2, IL1B, LIG1, MDC1, MRE11A, MSH2, NEIL3, NUPR1, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51, RAD51AP1, RAD51L1, RAD54B, RAD54L, RAD9A, RFC2, RFC3, RFC4, RPA2, SREBF1, SUPT16H, TDP1, TIPIN, TOP2A, TOPBP1, TRIB1, UNG	324	cellular response to stress
GO:0007051	5.031e-07	1.717	13 AURKA, BUB1B, ESPL1, KIF11, KIF23, NDC80, PRC1, SPAG5, STMN1, TACC3, TTK, UBE2C, ZWINT	25	spindle organization
GO:0016126	5.089e-07	2.335	15 C14orf1, CYP51A1, DHCR24, DHCR7, HMGCR, HMGCS1, IDI1, IDI2, LSS, MVD, NSDHL, SC4MOL, SC5DL, SQLE, TM7SF2	34	sterol biosynthetic process
GO:0051325	6.446e-07	5.081	22 BLM, BRCA2, CCNE1, CDC25C, CDC6, CDC7, CDK2, CDKN2D, CDKN3, CDT1, CENPF, CHEK1, DBF4, DDX11, GTSE1, PKIA, POLA1, POLD1, POLE, TIMELESS, TIPIN, TPD52L1	74	interphase
GO:0010564	1.214e-06	3.571	18 BRCA1, BRCA2, CDC25C, CDC7, CDT1, DLGAP5, ESPL1, IL1A, IL1B, KIF20B, KNTC1, NEK2, NUSAP1, PKIA, PKMYT1, TIMELESS, TIPIN, UBE2C	52	regulation of cell cycle process
GO:0051716	2.713e-06	23.42	53 BLM, BRCA1, BRCA2, BRIP1, BTG2, CCNA2, CDKN2D, CHAF1A, CHAF1B, CHEK1, DCLRE1B, DCLRE1C, EXO1, FADS1, FANCA, FANCG, FANCI, FEN1, GTSE1, HMGB2, IL1B, LIG1, MDC1, MRE11A, MSH2, NEIL3, NUPR1, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51, RAD51AP1, RAD51L1, RAD54B, RAD54L, RAD9A, RFC2, RFC3, RFC4, RPA2, SREBF1, SUPT16H, TDP1, TIPIN, TOP2A, TOPBP1, TRIB1, UNG	341	cellular response to stimulus
GO:0006694	4.216e-06	3.845	18 C14orf1, CYP51A1, DHCR24, DHCR7, HMGCR, HMGCS1, HSD17B2, HSD17B7, IDI1, IDI2, LSS, MVD, NR3C1, NSDHL, SC4MOL, SC5DL, SQLE, TM7SF2	56	steroid biosynthetic process
GO:0051329	8.007e-06	4.875	20 BLM, BRCA2, CCNE1, CDC25C, CDC6, CDC7, CDK2, CDKN2D, CDKN3, CDT1, CENPF, CHEK1, DBF4, DDX11, GTSE1, PKIA, POLA1, POLD1, POLE, TPD52L1	71	interphase of mitotic cell cycle
GO:0016125	9.060e-06	4.463	19 C14orf1, CYP51A1, DHCR24, DHCR7, HMGCR, HMGCS1, IDI1, IDI2, INSIG1, LDLR, LSS, MVD, NSDHL, SC4MOL, SC5DL, SQLE, SREBF1, SREBF2, TM7SF2	65	sterol metabolic process
GO:0030261	2.509e-05	1.03	9 NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NUSAP1, SMC2, SMC4, TOP2A	15	chromosome condensation
GO:0016043	3.195e-05	110.7	159 ADIPOR2, AGTR1, ARHGAP26, ARHGAP6, ASF1B, ASPM, AURKA, AURKB, BBS1, BIRC5, BLM, BMP2, BRCA1, BRCA2, BUB1, BUB1B, C13orf34, C14orf106, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CDKN2D, CDYL, CENPA, CENPE, CENPF, CENPJ, CEP55, CHAF1A, CHAF1B, CIT, COL14A1, CP110, CPA4, CSGALNACT1, DAAM2, DDX11, DHCR24, DIS3, DLGAP5, DSN1, ECT2, EGR2, ERCC6L, ESPL1, EXOSC9, EZH2, FAM29A, FANCA, FANCG, FBXO5, FHL3, GCH1, GOLGB1, HELLS, HIRIP3, HIST1H1C, HMGB2, IL1A, IL1B, IL6, JARID1B, JMJD3, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, KLF7, KNTC1, LDLR, MAD2L1, MCM2, MRE11A, MSH2, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEDD4L, NEDD9, NEK2, NR3C1, NUPR1, NUSAP1, OIP5, OPTN, PBK, PCNT, PDGFA, PDPN, PKMYT1, PLK1, PLSCR4, POLR2D, PRC1, PRKG1, PSRC1, PTTG1, PTTG3, QPRT, RACGAP1, RAD51, RAD54L, RBL1, RHOQ, RRM1, RRM2, RSL24D1, SHMT1, SLC1A3, SMC2, SMC4, SOX9, SPAG5, SPC25, SRF, STMN1, STX6, SUPT16H, SUV39H1, TACC3, TGFBR1, TIMELESS, TIPIN, TMEM48, TNXB, TOP2A, TPX2, TTF2, TTK, TUBGCP5, UBE2C, VCL, VEGFA, WEE1, WHSC1, WISP1, WNT2, ZWILCH, ZWINT	1612	cellular component organization
GO:0007076	3.975e-05	0.824	8 NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NUSAP1, SMC2, SMC4	12	mitotic chromosome condensation
GO:0051276	4.329e-05	18.81	43 ASF1B, BLM, BRCA2, CDYL, CENPA, CENPE, CENPF, CHAF1A, CHAF1B, CPA4, DDX11, DLGAP5, ESPL1, EZH2, HIRIP3, HIST1H1C, HMGB2, JARID1B, JMJD3, KIFC1, MCM2, MRE11A, MSH2, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NR3C1, NUSAP1, PTTG1, PTTG3, RAD54L, RBL1, SMC2, SMC4, SUPT16H, SUV39H1, TOP2A, WHSC1, ZWINT	274	chromosome organization
GO:0006695	5.572e-05	1.717	11 CYP51A1, DHCR24, DHCR7, HMGCR, HMGCS1, IDI1, IDI2, LSS, MVD, NSDHL, TM7SF2	25	cholesterol biosynthetic process
GO:0006297	9.381e-05	1.167	9 LIG1, POLD1, POLD3, POLE, POLE2, RFC2, RFC3, RFC4, RPA2	17	nucleotide-excision repair, DNA gap filling
GO:0031570	1.944e-04	1.923	11 BLM, BRIP1, CCNA2, CDC45L, CDC6, CDT1, CHEK1, GTSE1, MSH2, RAD9A, TIPIN	28	DNA integrity checkpoint
GO:0008202	3.149e-04	7.759	23 AGTR1, C14orf1, CYP51A1, DHCR24, DHCR7, HMGCR, HMGCS1, HSD17B2, HSD17B7, IDI1, IDI2, INSIG1, LDLR, LSS, MVD, NR3C1, NSDHL, SC4MOL, SC5DL, SQLE, SREBF1, SREBF2, TM7SF2	113	steroid metabolic process
GO:0051320	3.360e-04	1.03	8 BRCA2, CDC7, CDT1, DDX11, POLA1, POLD1, TIMELESS, TIPIN	15	S phase
GO:0006323	3.670e-04	4.189	16 ASF1B, CENPA, CHAF1A, CHAF1B, HIST1H1C, HMGB2, MCM2, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NUSAP1, SMC2, SMC4, TOP2A	61	DNA packaging
GO:0007093	3.969e-04	2.06	11 BLM, BUB1, BUB1B, CCNA2, CENPF, GTSE1, KNTC1, MAD2L1, TTK, ZWILCH, ZWINT	30	mitotic cell cycle checkpoint
GO:0000731	4.213e-04	0.5493	6 CDKN2D, POLA1, POLD1, POLD3, POLE, RFC3	8	DNA synthesis during DNA repair
GO:0006302	4.356e-04	2.472	12 BLM, BRCA1, BRCA2, BRIP1, FEN1, MRE11A, MSH2, POLA1, RAD51, RAD51AP1, RAD54B, RAD54L	36	double-strand break repair
GO:0008203	6.757e-04	3.914	15 CYP51A1, DHCR24, DHCR7, HMGCR, HMGCS1, IDI1, IDI2, INSIG1, LDLR, LSS, MVD, NSDHL, SREBF1, SREBF2, TM7SF2	57	cholesterol metabolic process
GO:0051052	1.173e-03	4.601	16 BLM, BRCA1, BRCA2, CDC45L, CDC6, CDK2, CDT1, GMNN, IL7R, MRE11A, MSH2, MYC, PDGFA, RAD51, RAD9A, TIPIN	67	regulation of DNA metabolic process
GO:0000076	1.213e-03	0.412	5 CDC45L, CDC6, CDT1, RAD9A, TIPIN	6	DNA replication checkpoint
GO:0032297	1.213e-03	0.412	5 CDC45L, CDC6, CDT1, RAD9A, TIPIN	6	negative regulation of DNA replication initiation
GO:0000724	2.041e-03	0.9613	7 BLM, BRCA1, BRCA2, RAD51, RAD51AP1, RAD54B, RAD54L	14	double-strand break repair via homologous recombination
GO:0000725	2.041e-03	0.9613	7 BLM, BRCA1, BRCA2, RAD51, RAD51AP1, RAD54B, RAD54L	14	recombinational repair
GO:0007088	2.292e-03	2.472	11 CDC25C, DLGAP5, ESPL1, IL1A, IL1B, KIF20B, KNTC1, NEK2, NUSAP1, PKMYT1, UBE2C	36	regulation of mitosis
GO:0006066	2.718e-03	13.39	30 ALDOC, C14orf1, CYP51A1, DHCR24, DHCR7, GALE, GALNAC4S-6ST, GCH1, GDPD5, GFPT2, GPD2, H6PD, HMGCR, HMGCS1, IDI1, IDI2, INSIG1, LDLR, LSS, MVD, MYC, NR3C1, NSDHL, PCK2, SC4MOL, SC5DL, SQLE, SREBF1, SREBF2, TM7SF2	195	cellular alcohol metabolic process
GO:0006310	3.213e-03	5.562	17 BLM, BRCA1, BRCA2, CHEK1, DCLRE1C, DMC1, EXO1, IL7R, LIG1, MRE11A, MSH2, PSMC3IP, RAD51, RAD51AP1, RAD51L1, RAD54B, RAD54L	81	DNA recombination
GO:0006950	3.327e-03	58.92	89 AGTR1, ANG, ANGPTL4, ATAD5, BARD1, BLM, BMP2, BRCA1, BRCA2, BRIP1, BTG2, CCL11, CCNA2, CDKN2D, CHAF1A, CHAF1B, CHEK1, CXCL3, DCLRE1B, DCLRE1C, DHCR24, DTL, EXO1, F10, FADS1, FANCA, FANCG, FANCI, FEN1, GCH1, GTSE1, HMGB2, HSPB3, IDH1, IFIH1, IL1A, IL1B, IL6, JMJD3, LIG1, LYST, MAFF, MCM7, MDC1, MRE11A, MSH2, MX1, MX2, NEIL3, NFKB1, NUPR1, PARP2, PDGFA, PLA2G4C, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51, RAD51AP1, RAD51L1, RAD54B, RAD54L, RAD9A, RFC2, RFC3, RFC4, RPA2, SCARA3, SGK1, SLC1A3, SREBF1, SRF, SUPT16H, TACC3, TDP1, TICAM1, TIMELESS, TIPIN, TNFAIP6, TOP2A, TOPBP1, TRIB1, TXNIP, UNG, VEGFA	858	response to stress
GO:0030174	3.347e-03	0.4807	5 CDC45L, CDC6, CDT1, RAD9A, TIPIN	7	regulation of DNA replication initiation
GO:0008283	3.815e-03	38.8	64 AGTR1, ANG, BLM, BMP2, BNC1, BRCA1, BRCA2, BTG2, BUB1, BUB1B, CDC25A, CDC25B, CDC25C, CDC6, CDC7, CDK2, CDKN2D, CDKN3, CENPF, CHEK1, CKS1B, CSGALNACT1, DDX11, DHCR7, DLGAP5, DTYMK, FABP3, FGFR1OP, GINS1, IL1A, IL1B, IL6, INSIG1, JARID2, KIF15, KIF2C, LIF, MCM7, MKI67, MYC, NAMPT, NUPR1, PDGFA, PDGFD, PDGFRB, PLK1, POLA1, PTGES, PTHLH, SOX9, STIL, TACC3, TACSTD2, TFDP1, TGFBR1, TIMELESS, TIPIN, TNFSF9, TNS3, TPX2, TRIB1, TTK, VEGFA, WNT2	565	cell proliferation
GO:0048015	4.816e-03	3.159	12 AGTR1, AURKA, BUB1B, FEN1, HMGB2, NDC80, PIK3CD, RFC4, SPAG5, TOP2A, UBE2C, ZWINT	46	phosphoinositide-mediated signaling
GO:0007018	5.258e-03	4.189	14 BBS1, CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1	61	microtubule-based movement
GO:0008156	6.548e-03	1.511	8 BLM, BRCA2, CDC45L, CDC6, CDT1, GMNN, RAD9A, TIPIN	22	negative regulation of DNA replication
GO:0007126	6.979e-03	3.296	12 BRCA2, CHEK1, DMC1, ESPL1, EXO1, MRE11A, NEK2, PSMC3IP, RAD51, RAD51L1, RAD54B, RAD54L	48	meiosis
GO:0051321	6.979e-03	3.296	12 BRCA2, CHEK1, DMC1, ESPL1, EXO1, MRE11A, NEK2, PSMC3IP, RAD51, RAD51L1, RAD54B, RAD54L	48	meiotic cell cycle
GO:0051327	6.979e-03	3.296	12 BRCA2, CHEK1, DMC1, ESPL1, EXO1, MRE11A, NEK2, PSMC3IP, RAD51, RAD51L1, RAD54B, RAD54L	48	M phase of meiotic cell cycle
GO:0030705	7.328e-03	4.875	15 BBS1, CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, MYO1E	71	cytoskeleton-dependent intracellular transport
GO:0008610	8.650e-03	13.05	28 ACACA, ANG, BRCA1, C14orf1, CYP51A1, DHCR24, DHCR7, FABP3, FADS1, FADS2, HMGCR, HMGCS1, HSD17B2, HSD17B7, IDI1, IDI2, LSS, MVD, NR3C1, NSDHL, PDGFA, PIGB, PIGZ, SC4MOL, SC5DL, SCD, SQLE, TM7SF2	190	lipid biosynthetic process
GO:0051053	8.769e-03	1.991	9 BLM, BRCA2, CDC45L, CDC6, CDT1, GMNN, MSH2, RAD9A, TIPIN	29	negative regulation of DNA metabolic process
GO:0000079	1.421e-02	3.09	11 BLM, C13orf15, CCNE2, CDC25A, CDC25C, CDC6, CDKN2D, CDKN3, CHEK1, CKS1B, PKMYT1	45	regulation of cyclin-dependent protein kinase activity
GO:0000077	1.466e-02	1.717	8 BLM, BRIP1, CCNA2, CHEK1, GTSE1, MSH2, RAD9A, TIPIN	25	DNA damage checkpoint
GO:0019932	1.540e-02	6.455	17 AGTR1, AURKA, BUB1B, FEN1, HMGB2, MC4R, NDC80, PIK3CD, PTGER4, PTHLH, RAPGEF2, RCAN2, RFC4, SPAG5, TOP2A, UBE2C, ZWINT	94	second-messenger-mediated signaling
GO:0045840	1.540e-02	0.9613	6 DLGAP5, ESPL1, IL1A, IL1B, NUSAP1, UBE2C	14	positive regulation of mitosis
GO:0042770	1.666e-02	3.159	11 BLM, BRCA1, BRCA2, BRIP1, CCNA2, CHEK1, GTSE1, MSH2, NUPR1, RAD9A, TIPIN	46	DNA damage response, signal transduction
GO:0033261	2.083e-02	0.6867	5 BRCA2, CDC7, CDT1, TIMELESS, TIPIN	10	regulation of S phase
GO:0006289	2.254e-02	3.296	11 BRCA2, LIG1, NEIL3, POLD1, POLD3, POLE, POLE2, RFC2, RFC3, RFC4, RPA2	48	nucleotide-excision repair
GO:0006271	2.290e-02	0.206	3 POLA1, RFC3, RFC4	3	DNA strand elongation during DNA replication
GO:0048478	2.290e-02	0.206	3 BLM, BRCA2, TIPIN	3	replication fork protection
GO:0006275	2.401e-02	2.815	10 BLM, BRCA2, CDC45L, CDC6, CDK2, CDT1, GMNN, PDGFA, RAD9A, TIPIN	41	regulation of DNA replication
GO:0009987	2.723e-02	452.4	473 ACACA, ACADVL, ACYP1, ADAMTS5, ADIPOR2, AGTR1, ALDOC, ANG, ANGPTL2, ANGPTL4, ANK2, ANXA3, AQP3, ARHGAP11A, ARHGAP19, ARHGAP26, ARHGAP5, ARHGAP6, ARL6IP1, ASAP2, ASF1B, ASPM, ATAD2, ATF3, AURKA, AURKB, B3GALT2, B3GNT2, BACH1, BARD1, BBS1, BEX1, BIRC5, BLM, BMP2, BNC1, BRCA1, BRCA2, BRIP1, BTG2, BUB1, BUB1B, C13orf15, C13orf34, C14orf1, C14orf106, C18orf24, C21orf45, CASP1, CASP2, CBS, CCL11, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CCNF, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDK5RAP2, CDKN2D, CDKN3, CDT1, CDYL, CENPA, CENPE, CENPF, CENPJ, CENPO, CEP55, CHAF1A, CHAF1B, CHEK1, CIT, CKAP2, CKS1B, CLCN6, COL14A1, COL16A1, COL21A1, CORIN, CP110, CPA3, CPA4, CREB5, CSGALNACT1, CSTA, CSTF2, CTSF, CTSO, CXCR7, CYFIP2, CYP51A1, DAAM2, DACT1, DBF4, DCLK1, DCLRE1B, DCLRE1C, DCP1A, DDX11, DDX12, DEK, DEPDC1, DHCR24, DHCR7, DHFR, DHRS3, DIS3, DKFZP586H2123, DLGAP5, DMC1, DMD, DNA2, DPYSL2, DRAM, DSCC1, DSN1, DTL, DTYMK, DVL3, E2F8, ECM2, ECT2, EGR2, ENOX1, EPHB6, ERCC6L, ESPL1, EXO1, EXOSC9, EZH2, F10, FABP3, FADS1, FADS2, FAM29A, FANCA, FANCG, FANCI, FBXO5, FBXW7, FEN1, FGFR1OP, FHL3, FOSB, FOXM1, FRY, GALE, GALNAC4S-6ST, GCH1, GDF15, GDPD5, GFPT2, GINS1, GINS2, GINS3, GINS4, GLA, GMNN, GOLGB1, GPD2, GPR183, GPR37, GRIA3, GTSE1, H6PD, HELLS, HERC6, HIRIP3, HIST1H1C, HIVEP1, HIVEP2, HMGB2, HMGB3, HMGCR, HMGCS1, HNRNPA2B1, HOXA10, HOXA9, HSD17B2, HSD17B7, ICAM1, IDH1, IDI1, IDI2, IFIH1, IL1A, IL1B, IL6, IL7R, INSIG1, IRF7, ITGB3BP, JARID1B, JARID2, JMJD3, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, KLF13, KLF7, KNTC1, LAMC2, LDLR, LIF, LIG1, LMCD1, LSM2, LSM5, LSS, LYST, MAD2L1, MAFF, MAN1C1, MAP3K8, MC4R, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDC1, MELK, MFAP4, MKI67, MLF1IP, MLXIP, MMP3, MPHOSPH9, MRE11A, MSC, MSH2, MVD, MX1, MYBL2, MYC, MYO1E, NAMPT, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NCOA1, NDC80, NDRG1, NEDD4L, NEDD9, NEIL3, NEK2, NFATC1, NFIL3, NFKB1, NME5, NPAT, NR3C1, NR4A1, NR4A2, NR4A3, NSDHL, NUP107, NUP155, NUP85, NUP93, NUPR1, NUSAP1, OIP5, OMD, OPTN, ORC1L, ORC6L, PANK3, PANX1, PAPPA, PARP2, PBK, PCK2, PCNT, PCSK7, PDE4A, PDGFA, PDGFD, PDGFRB, PDPN, PEG10, PIGB, PIGZ, PIK3CD, PIP5K1A, PIR, PITPNC1, PKIA, PKMYT1, PLA2G4C, PLK1, PLK4, PLSCR4, PLXNC1, PMEPA1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PPL, PPP3CC, PRC1, PRELP, PRIM1, PRKG1, PRPS2, PRSS12, PSMC3IP, PSRC1, PTGER4, PTGES, PTHLH, PTTG1, PTTG3, QPRT, RAB33A, RACGAP1, RAD51, RAD51AP1, RAD51L1, RAD54B, RAD54L, RAD9A, RANGAP1, RAPGEF2, RASGRP1, RASGRP3, RASSF8, RBL1, RCAN2, REL, RELB, RFC2, RFC3, RFC4, RGS7, RHOQ, RICS, RLF, RMI1, RNASEH2A, ROR1, RPA2, RPL39L, RPP30, RRAGB, RRM1, RRM2, RSL24D1, RUNX1, SAMD4A, SAP30, SC4MOL, SC5DL, SCD, SEMA3D, SGK1, SHMT1, SKIL, SLC19A2, SLC1A3, SLC29A1, SLC2A14, SLC2A3, SMC2, SMC4, SMOX, SOX9, SPAG5, SPC25, SPRED2, SPSB1, SQLE, SREBF1, SREBF2, SRF, SSX2IP, ST3GAL1, STAC, STIL, STK38L, STMN1, STX6, SUPT16H, SUV39H1, SVEP1, TACC3, TACSTD2, TBC1D12, TCEA2, TDP1, TFDP1, TGFBR1, TICAM1, TIMELESS, TIPIN, TK1, TM7SF2, TMEM48, TMPO, TNFAIP6, TNFAIP8, TNFRSF10B, TNFRSF21, TNFSF9, TNS3, TNXB, TOP2A, TOPBP1, TP53BP2, TPD52L1, TPX2, TRAPPC6A, TRIB1, TRIP13, TRMT5, TROAP, TRPC6, TRPS1, TSC22D3, TTF2, TTK, TUBGCP5, TXNIP, UBA7, UBE2C, UBR7, UNG, USPL1, UST, VCL, VDR, VEGFA, VRK1, WEE1, WHSC1, WISP1, WNT2, XAF1, YOD1, ZNF394, ZNF85, ZWILCH, ZWINT	6588	cellular process
GO:0044255	2.725e-02	24.65	42 ACACA, ACADVL, ADIPOR2, AGTR1, ANG, BBS1, BRCA1, C14orf1, CYP51A1, DHCR24, DHCR7, DHRS3, FABP3, FADS1, FADS2, GLA, HMGCR, HMGCS1, HSD17B2, HSD17B7, IDI1, IDI2, INSIG1, LDLR, LSS, MVD, NR3C1, NSDHL, PDGFA, PIGB, PIGZ, PIK3CD, PIP5K1A, PLA2G4C, PTGES, SC4MOL, SC5DL, SCD, SQLE, SREBF1, SREBF2, TM7SF2	359	cellular lipid metabolic process
GO:0007131	2.920e-02	1.099	6 CHEK1, DMC1, MRE11A, RAD51, RAD51L1, RAD54B	16	reciprocal meiotic recombination
GO:0006268	3.095e-02	0.7553	5 HMGB2, MCM2, MCM4, MCM7, RAD51	11	DNA unwinding during replication
GO:0007010	3.581e-02	17.51	32 ARHGAP26, ARHGAP6, AURKA, BBS1, BRCA1, BRCA2, BUB1B, CENPJ, CP110, DAAM2, ESPL1, FHL3, KIF11, KIF23, KIF2C, NDC80, NEDD9, NEK2, NUSAP1, PDGFA, PRC1, PRKG1, PSRC1, RACGAP1, SPAG5, STMN1, TACC3, TTK, TUBGCP5, UBE2C, WNT2, ZWINT	255	cytoskeleton organization
GO:0000084	4.316e-02	0.824	5 BRCA2, CDT1, DDX11, POLA1, POLD1	12	S phase of mitotic cell cycle
GO:0000086	4.316e-02	0.824	5 CDK2, CHEK1, DDX11, PKIA, TPD52L1	12	G2/M transition of mitotic cell cycle
GO:0007052	4.316e-02	0.824	5 KIF11, KIF23, PRC1, STMN1, TTK	12	mitotic spindle organization
GO:0007127	4.502e-02	1.648	7 CHEK1, DMC1, ESPL1, MRE11A, RAD51, RAD51L1, RAD54B	24	meiosis I
GO:0044249	4.847e-02	159.9	192 ACACA, AGTR1, ANG, ASF1B, ATAD2, ATF3, B3GALT2, B3GNT2, BACH1, BLM, BMP2, BNC1, BRCA1, BRCA2, BRIP1, BTG2, C14orf1, CBS, CCNA2, CCNE1, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDKN2D, CDT1, CDYL, CENPF, CHAF1A, CHAF1B, CHEK1, CREB5, CSGALNACT1, CYP51A1, DBF4, DEK, DHCR24, DHCR7, DMD, DNA2, DSCC1, DTL, DVL3, E2F8, EGR2, EXO1, EZH2, FABP3, FADS1, FADS2, FEN1, FOSB, FOXM1, FRY, GALNAC4S-6ST, GCH1, GINS1, GINS2, GINS3, GINS4, GMNN, GPD2, HELLS, HIVEP1, HIVEP2, HMGB2, HMGCR, HMGCS1, HOXA10, HOXA9, HSD17B2, HSD17B7, IDI1, IDI2, IL1A, IL1B, IL6, INSIG1, IRF7, ITGB3BP, JARID1B, JARID2, JMJD3, KLF13, KLF7, LDLR, LIF, LIG1, LMCD1, LSS, MAFF, MAN1C1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MLF1IP, MLXIP, MRE11A, MSC, MSH2, MVD, MYBL2, MYC, NAMPT, NCOA1, NFATC1, NFIL3, NFKB1, NPAT, NR3C1, NR4A1, NR4A2, NR4A3, NSDHL, ORC1L, ORC6L, PANK3, PCK2, PDGFA, PIGB, PIGZ, PIR, PKIA, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRIM1, PRPS2, PSRC1, PTHLH, PTTG1, QPRT, RAD51, RAD54B, RAD9A, RBL1, REL, RELB, RFC2, RFC3, RFC4, RLF, RMI1, RNASEH2A, RPA2, RPL39L, RSL24D1, RUNX1, SAMD4A, SAP30, SC4MOL, SC5DL, SCD, SHMT1, SKIL, SOX9, SQLE, SREBF1, SREBF2, SRF, ST3GAL1, SUPT16H, SUV39H1, TCEA2, TFDP1, TGFBR1, TIMELESS, TIPIN, TK1, TM7SF2, TMPO, TOP2A, TRIB1, TRIP13, TRPS1, TSC22D3, TTF2, TXNIP, VDR, WHSC1, ZNF394, ZNF85	2328	cellular biosynthetic process

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005694	6.810e-23	17.02	70 ASF1B, AURKB, BIRC5, BLM, BRCA1, BUB1, BUB1B, C14orf106, C18orf24, C21orf45, CDCA8, CDT1, CDYL, CENPA, CENPC1, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, CHEK1, DMC1, DSN1, ERCC6L, FANCI, HIST1H1C, HMGB2, HMGB3, ITGB3BP, KIF22, KIF2C, KNTC1, MAD2L1, MCM2, MCM3, MCM7, MLF1IP, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NUP107, NUP85, OIP5, ORC6L, POLA1, POLA2, POLD3, PRIM1, RANGAP1, RFC2, RFC3, RFC4, RPA2, SMC2, SMC4, SPAG5, SPC25, SUPT16H, SUV39H1, TELO2, TIMELESS, TIPIN, TMPO, TOP2A, TOPBP1, ZWILCH, ZWINT	248	chromosome
GO:0044427	3.268e-21	13.59	60 ASF1B, AURKB, BLM, BUB1, BUB1B, C14orf106, C18orf24, C21orf45, CDCA8, CDT1, CDYL, CENPA, CENPC1, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, CHEK1, DSN1, ERCC6L, ITGB3BP, KIF22, KIF2C, KNTC1, MAD2L1, MCM2, MCM3, MCM7, MLF1IP, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NUP107, NUP85, OIP5, ORC6L, POLA1, POLA2, POLD3, PRIM1, RANGAP1, RFC2, RFC3, RFC4, RPA2, SMC2, SMC4, SPAG5, SPC25, SUV39H1, TELO2, TIMELESS, TIPIN, TMPO, ZWILCH, ZWINT	198	chromosomal part
GO:0000775	1.216e-19	4.323	33 AURKB, BUB1, BUB1B, C14orf106, C18orf24, C21orf45, CDCA8, CENPA, CENPC1, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, DSN1, ERCC6L, ITGB3BP, KIF22, KIF2C, KNTC1, MAD2L1, MLF1IP, NDC80, NUP107, NUP85, OIP5, RANGAP1, SPAG5, SPC25, SUV39H1, ZWILCH, ZWINT	63	chromosome, centromeric region
GO:0000793	7.325e-19	4.529	33 BLM, BRCA1, BUB1, BUB1B, C18orf24, CENPA, CENPC1, CENPE, CENPF, CENPM, CHEK1, DMC1, DSN1, ERCC6L, HMGB2, KNTC1, MLF1IP, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NUP107, NUP85, RANGAP1, SMC2, SMC4, SPAG5, SPC25, SUV39H1, TOPBP1, ZWILCH, ZWINT	66	condensed chromosome
GO:0005819	4.144e-13	5.489	30 AURKA, AURKB, BUB1, BUB1B, C18orf24, CDC2, CDC20, CDC6, CENPE, CENPF, DLGAP5, FAM29A, FBXO5, KIF11, KIF14, KIF15, KIF23, KIF4A, KIFC1, KNTC1, MYC, NEDD9, NUP85, PRC1, PSRC1, RACGAP1, SPAG5, TPX2, TTK, TUBGCP5	80	spindle
GO:0000777	4.475e-13	2.333	20 BUB1, BUB1B, C18orf24, CENPA, CENPC1, CENPE, CENPF, CENPM, DSN1, ERCC6L, KNTC1, MLF1IP, NDC80, NUP107, NUP85, RANGAP1, SPAG5, SPC25, ZWILCH, ZWINT	34	condensed chromosome kinetochore
GO:0000779	4.475e-13	2.333	20 BUB1, BUB1B, C18orf24, CENPA, CENPC1, CENPE, CENPF, CENPM, DSN1, ERCC6L, KNTC1, MLF1IP, NDC80, NUP107, NUP85, RANGAP1, SPAG5, SPC25, ZWILCH, ZWINT	34	condensed chromosome, centromeric region
GO:0043228	6.286e-13	92.63	164 ALDOC, ANGPTL4, ANK2, ARHGAP26, ARHGAP6, ASF1B, ATF3, AURKA, AURKB, BACH1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C14orf106, C18orf24, C21orf45, CASP1, CBS, CCNB1, CCNB2, CDC2, CDC20, CDC25B, CDC45L, CDC6, CDCA8, CDK5RAP2, CDT1, CDYL, CENPA, CENPC1, CENPE, CENPF, CENPI, CENPJ, CENPM, CENPO, CENPQ, CEP192, CEP97, CHEK1, CKAP2, CP110, CSTA, CSTF2, CTSO, DDX11, DLGAP5, DMC1, DMD, DPYSL2, DSN1, ERCC6L, ESPL1, EXOSC9, FAM29A, FANCI, FBXO5, FGFR1OP, FHL3, GABARAPL1, GABARAPL3, GTSE1, HIST1H1C, HMGB2, HMGB3, ITGB3BP, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, KNTC1, KRTAP1-1, LMNB1, LMNB2, LOC81691, LYST, MAD2L1, MCM2, MCM3, MCM4, MCM7, MDC1, MKI67, MLF1IP, MRE11A, MYBL1, MYC, MYL5, MYO19, MYO1E, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NDRG1, NEDD9, NEK2, NR3C1, NUP107, NUP85, NUSAP1, OIP5, ORC6L, PARP2, PCNT, PLK1, POLA1, POLA2, POLD3, PPL, PRC1, PRIM1, PRKG1, PSRC1, RACGAP1, RAD9A, RANGAP1, RFC2, RFC3, RFC4, RGS7, RPA2, RPL39L, RPP30, RSL24D1, SMC2, SMC4, SNTB1, SOX9, SPAG5, SPC25, SRF, STMN1, SUPT16H, SUV39H1, TELO2, TIMELESS, TIPIN, TMPO, TNS3, TOP2A, TOPBP1, TPX2, TRMT5, TTK, TUBGCP5, VCL, WDHD1, ZWILCH, ZWINT	1350	non-membrane-bounded organelle
GO:0043232	6.286e-13	92.63	164 ALDOC, ANGPTL4, ANK2, ARHGAP26, ARHGAP6, ASF1B, ATF3, AURKA, AURKB, BACH1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C14orf106, C18orf24, C21orf45, CASP1, CBS, CCNB1, CCNB2, CDC2, CDC20, CDC25B, CDC45L, CDC6, CDCA8, CDK5RAP2, CDT1, CDYL, CENPA, CENPC1, CENPE, CENPF, CENPI, CENPJ, CENPM, CENPO, CENPQ, CEP192, CEP97, CHEK1, CKAP2, CP110, CSTA, CSTF2, CTSO, DDX11, DLGAP5, DMC1, DMD, DPYSL2, DSN1, ERCC6L, ESPL1, EXOSC9, FAM29A, FANCI, FBXO5, FGFR1OP, FHL3, GABARAPL1, GABARAPL3, GTSE1, HIST1H1C, HMGB2, HMGB3, ITGB3BP, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, KNTC1, KRTAP1-1, LMNB1, LMNB2, LOC81691, LYST, MAD2L1, MCM2, MCM3, MCM4, MCM7, MDC1, MKI67, MLF1IP, MRE11A, MYBL1, MYC, MYL5, MYO19, MYO1E, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NDRG1, NEDD9, NEK2, NR3C1, NUP107, NUP85, NUSAP1, OIP5, ORC6L, PARP2, PCNT, PLK1, POLA1, POLA2, POLD3, PPL, PRC1, PRIM1, PRKG1, PSRC1, RACGAP1, RAD9A, RANGAP1, RFC2, RFC3, RFC4, RGS7, RPA2, RPL39L, RPP30, RSL24D1, SMC2, SMC4, SNTB1, SOX9, SPAG5, SPC25, SRF, STMN1, SUPT16H, SUV39H1, TELO2, TIMELESS, TIPIN, TMPO, TNS3, TOP2A, TOPBP1, TPX2, TRMT5, TTK, TUBGCP5, VCL, WDHD1, ZWILCH, ZWINT	1350	intracellular non-membrane-bounded organelle
GO:0000776	4.953e-12	3.156	22 BUB1, BUB1B, C18orf24, CENPA, CENPC1, CENPE, CENPF, CENPM, DSN1, ERCC6L, KIF22, KNTC1, MAD2L1, MLF1IP, NDC80, NUP107, NUP85, RANGAP1, SPAG5, SPC25, ZWILCH, ZWINT	46	kinetochore
GO:0015630	1.922e-11	22.09	61 AURKA, AURKB, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C18orf24, CCNB1, CCNB2, CDC2, CDC20, CDC25B, CDC45L, CDC6, CDK5RAP2, CENPE, CENPF, CENPJ, CEP192, CEP97, CKAP2, CP110, DLGAP5, ESPL1, FAM29A, FBXO5, FGFR1OP, GABARAPL1, GABARAPL3, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, KNTC1, LYST, MYC, NEDD9, NEK2, NUP85, NUSAP1, PCNT, PLK1, PRC1, PSRC1, RACGAP1, SPAG5, STMN1, TOP2A, TPX2, TTK, TUBGCP5	322	microtubule cytoskeleton
GO:0005634	1.316e-10	212.1	291 ADAMTS5, ANG, ANGPTL4, ARHGAP19, ASF1B, ASPM, ATAD2, ATAD5, ATF3, AURKA, AURKB, BACH1, BARD1, BEX1, BEX4, BIRC5, BLM, BNC1, BRCA1, BRCA2, BRIP1, BTG2, BUB1, BUB1B, C12orf48, C13orf15, C14orf106, C21orf45, CASP1, CBS, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CCNF, CCNJ, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDCA4, CDCA8, CDK2, CDKN2AIP, CDKN2D, CDT1, CDYL, CENPA, CENPC1, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, CHAF1A, CHAF1B, CHEK1, CKS1B, CPA3, CREB5, CSTA, CSTF2, DACT1, DBF4, DCLRE1B, DCLRE1C, DCP1A, DDX11, DDX12, DEK, DEPDC1, DHCR24, DHCR7, DIS3, DLGAP5, DMC1, DMD, DNA2, DSCC1, DSN1, DTL, E2F8, EGR2, ESPL1, EXO1, EXOSC9, EZH2, FANCA, FANCG, FANCI, FBXO5, FBXW7, FEN1, FHL3, FOSB, FOXM1, GALE, GCH1, GINS1, GINS2, GINS3, GINS4, GLTSCR2, GMNN, HCFC1R1, HELLS, HIRIP3, HIST1H1C, HIVEP1, HJURP, HMGB1L10, HMGB2, HMGB3, HNRNPA2B1, HOXA10, HOXA9, IFI35, IFIH1, IRF7, ITGB3BP, ITPKC, JARID1B, JARID2, JMJD3, KIAA0586, KIF11, KIF14, KIF18A, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, KLF13, KLF7, KNTC1, LIG1, LMCD1, LMNB1, LMNB2, LOC81691, LSM2, LSM5, LUZP1, MAD2L1, MAFF, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDC1, MDM1, MKI67, MLF1IP, MLXIP, MRE11A, MSC, MSH2, MX2, MYBL1, MYBL2, MYC, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NCOA1, NDC80, NDRG1, NEDD9, NEIL3, NEK2, NFATC1, NFIL3, NFKB1, NPAT, NR3C1, NR4A1, NR4A2, NR4A3, NUP107, NUP155, NUP85, NUP93, NUPR1, NUSAP1, OIP5, ORC1L, ORC6L, PARP12, PARP2, PEG10, PIR, PKIA, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PPL, PRC1, PRIM1, PRKG1, PSMC3IP, PTGES, PTHLH, PTTG1, PTTG3, RACGAP1, RAD51, RAD51AP1, RAD51L1, RAD54B, RAD54L, RAD9A, RANGAP1, RBL1, REL, RELB, RFC2, RFC3, RFC4, RGS7, RLF, RMI1, RNASEH2A, RPA2, RPP30, RRAGB, RSL24D1, RUNX1, SAP30, SGK1, SKIL, SKIV2L, SMC2, SMC4, SOX9, SPC25, SREBF1, SREBF2, SRF, SSX2IP, SUPT16H, SUV39H1, TCEA2, TDP1, TELO2, TFDP1, TIMELESS, TIPIN, TMEM48, TMPO, TNS3, TOP2A, TOPBP1, TP53BP2, TPX2, TRIB1, TRIP13, TRMT5, TRPS1, TTF2, UBE2C, UBR7, UNG, VDR, VRK1, WDHD1, WEE1, WHSC1, XAF1, ZNF394, ZNF85, ZWINT	3091	nucleus
GO:0044430	3.453e-09	28.82	67 ARHGAP6, AURKA, AURKB, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C18orf24, CCNB1, CDC2, CDC20, CDC25B, CDC45L, CDC6, CDK5RAP2, CENPE, CENPF, CENPJ, CEP192, CEP97, CKAP2, CP110, DLGAP5, ESPL1, FAM29A, FBXO5, FGFR1OP, FHL3, GABARAPL1, GABARAPL3, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, KNTC1, KRTAP1-1, LMNB1, LMNB2, MYC, MYL5, MYO19, MYO1E, NEDD9, NEK2, NUP85, NUSAP1, PCNT, PLK1, PRC1, PSRC1, RACGAP1, SPAG5, STMN1, TOP2A, TPX2, TTK, TUBGCP5	420	cytoskeletal part
GO:0005657	2.678e-07	1.784	13 BLM, CDT1, CHEK1, MCM3, MCM7, POLA1, POLA2, POLD3, PRIM1, RFC2, RFC3, RFC4, RPA2	26	replication fork
GO:0000228	2.096e-06	5.284	21 BLM, BUB1, CHEK1, DMC1, HMGB2, MCM2, MCM3, MCM7, NCAPD2, NCAPD3, ORC6L, POLA1, POLA2, POLD3, PRIM1, RPA2, SMC2, SUV39H1, TIMELESS, TIPIN, TOPBP1	77	nuclear chromosome
GO:0005654	2.791e-06	39.11	74 BLM, BRCA1, BRCA2, CCNA2, CCNB1, CCNE1, CCNE2, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CHAF1A, CHAF1B, CHEK1, CKS1B, DBF4, DNA2, E2F8, EZH2, FBXO5, GMNN, KIF20A, KIF20B, KIF23, LIG1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDC1, MRE11A, MYC, NFKB1, NR4A1, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRIM1, RAD51, RBL1, RFC2, RFC3, RFC4, RPA2, SAP30, SUPT16H, SUV39H1, TCEA2, TFDP1, TOP2A, TOPBP1, TTF2, UBE2C, WDHD1, WEE1	570	nucleoplasm
GO:0044428	3.394e-06	77.81	123 ANGPTL4, ATF3, BACH1, BARD1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C14orf106, CASP1, CBS, CCNA2, CCNB1, CCNE1, CCNE2, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CKS1B, CSTF2, DBF4, DDX11, DHCR7, DMC1, DNA2, DTL, E2F8, EXOSC9, EZH2, FBXO5, GMNN, HMGB2, HNRNPA2B1, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, LOC81691, LSM2, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDC1, MKI67, MRE11A, MSH2, MYBL1, MYC, NCAPD2, NCAPD3, NFKB1, NR3C1, NR4A1, NUP107, NUP155, NUP85, NUP93, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRIM1, PRKG1, PTGES, RAD51, RAD9A, RANGAP1, RBL1, RFC2, RFC3, RFC4, RGS7, RPA2, RPP30, SAP30, SMC2, SOX9, SREBF1, SRF, SUPT16H, SUV39H1, TCEA2, TFDP1, TIMELESS, TIPIN, TMEM48, TMPO, TNS3, TOP2A, TOPBP1, TRMT5, TTF2, UBE2C, WDHD1, WEE1	1134	nuclear part
GO:0031981	3.773e-06	59.35	100 ANGPTL4, ATF3, BACH1, BIRC5, BLM, BRCA1, BRCA2, C14orf106, CASP1, CBS, CCNA2, CCNB1, CCNE1, CCNE2, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CKS1B, CSTF2, DBF4, DDX11, DNA2, E2F8, EXOSC9, EZH2, FBXO5, GMNN, HMGB2, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, LOC81691, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDC1, MKI67, MRE11A, MYBL1, MYC, NFKB1, NR3C1, NR4A1, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRIM1, PRKG1, RAD51, RAD9A, RBL1, RFC2, RFC3, RFC4, RGS7, RPA2, RPP30, SAP30, SOX9, SRF, SUPT16H, SUV39H1, TCEA2, TFDP1, TNS3, TOP2A, TOPBP1, TRMT5, TTF2, UBE2C, WDHD1, WEE1	865	nuclear lumen
GO:0044446	6.643e-06	184.9	242 ABCA5, ACADVL, ANGPTL4, ARHGAP6, ARL6IP1, ASF1B, ATF3, ATP6V1G2, AURKA, AURKB, B3GALT2, B3GNT2, BACH1, BARD1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C14orf1, C14orf106, C18orf24, C21orf45, C4orf18, CASP1, CBS, CCNA2, CCNB1, CCNE1, CCNE2, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDK5RAP2, CDT1, CDYL, CENPA, CENPC1, CENPE, CENPF, CENPI, CENPJ, CENPM, CENPO, CENPQ, CEP192, CEP97, CHAF1A, CHAF1B, CHEK1, CKAP2, CKS1B, CP110, CSGALNACT1, CSTF2, CYP51A1, DBF4, DDX11, DHCR24, DHCR7, DLGAP5, DMC1, DNA2, DRAM, DSN1, DTL, E2F8, ENTPD7, ERCC6L, ESPL1, EXOSC9, EZH2, FADS1, FADS2, FAM29A, FBXO5, FGFR1OP, FHL3, GABARAPL1, GABARAPL3, GALNAC4S-6ST, GMNN, GOLGB1, GPD2, GPR37, GTSE1, H6PD, HMGB2, HMGCR, HNRNPA2B1, HSD17B2, HSD17B7, INSIG1, ITGB3BP, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, KNTC1, KRTAP1-1, LDLR, LIG1, LMNB1, LMNB2, LOC81691, LSM2, MAD2L1, MAN1C1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDC1, MKI67, MLF1IP, MLXIP, MPHOSPH9, MRE11A, MSH2, MYBL1, MYC, MYL5, MYO19, MYO1E, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NEDD9, NEK2, NFKB1, NR3C1, NR4A1, NSDHL, NUP107, NUP155, NUP85, NUP93, NUSAP1, OIP5, ORC1L, ORC6L, PARP2, PCNT, PCSK7, PDGFA, PIGB, PIGZ, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRC1, PRIM1, PRKG1, PSRC1, PTGES, RACGAP1, RAD51, RAD9A, RANGAP1, RASGRP1, RBL1, RFC2, RFC3, RFC4, RGS7, RICS, RPA2, RPL39L, RPP30, RTN2, SAP30, SC4MOL, SC5DL, SCARA3, SCD, SMC2, SMC4, SOX9, SPAG5, SPC25, SQLE, SREBF1, SREBF2, SRF, ST3GAL1, STMN1, STX6, SUPT16H, SUV39H1, TCEA2, TELO2, TFDP1, TIMELESS, TIPIN, TM7SF2, TMEM106C, TMEM48, TMPO, TNS3, TOP2A, TOPBP1, TPX2, TRMT5, TTF2, TTK, TUBGCP5, UBE2C, UST, VEGFA, WDHD1, WEE1, WNT2, ZWILCH, ZWINT	2695	intracellular organelle part
GO:0000796	7.224e-06	0.4117	6 NCAPD2, NCAPD3, NCAPG, NCAPH, SMC2, SMC4	6	condensin complex
GO:0044422	9.300e-06	185.6	242 ABCA5, ACADVL, ANGPTL4, ARHGAP6, ARL6IP1, ASF1B, ATF3, ATP6V1G2, AURKA, AURKB, B3GALT2, B3GNT2, BACH1, BARD1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C14orf1, C14orf106, C18orf24, C21orf45, C4orf18, CASP1, CBS, CCNA2, CCNB1, CCNE1, CCNE2, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDK5RAP2, CDT1, CDYL, CENPA, CENPC1, CENPE, CENPF, CENPI, CENPJ, CENPM, CENPO, CENPQ, CEP192, CEP97, CHAF1A, CHAF1B, CHEK1, CKAP2, CKS1B, CP110, CSGALNACT1, CSTF2, CYP51A1, DBF4, DDX11, DHCR24, DHCR7, DLGAP5, DMC1, DNA2, DRAM, DSN1, DTL, E2F8, ENTPD7, ERCC6L, ESPL1, EXOSC9, EZH2, FADS1, FADS2, FAM29A, FBXO5, FGFR1OP, FHL3, GABARAPL1, GABARAPL3, GALNAC4S-6ST, GMNN, GOLGB1, GPD2, GPR37, GTSE1, H6PD, HMGB2, HMGCR, HNRNPA2B1, HSD17B2, HSD17B7, INSIG1, ITGB3BP, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, KNTC1, KRTAP1-1, LDLR, LIG1, LMNB1, LMNB2, LOC81691, LSM2, MAD2L1, MAN1C1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDC1, MKI67, MLF1IP, MLXIP, MPHOSPH9, MRE11A, MSH2, MYBL1, MYC, MYL5, MYO19, MYO1E, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NEDD9, NEK2, NFKB1, NR3C1, NR4A1, NSDHL, NUP107, NUP155, NUP85, NUP93, NUSAP1, OIP5, ORC1L, ORC6L, PARP2, PCNT, PCSK7, PDGFA, PIGB, PIGZ, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRC1, PRIM1, PRKG1, PSRC1, PTGES, RACGAP1, RAD51, RAD9A, RANGAP1, RASGRP1, RBL1, RFC2, RFC3, RFC4, RGS7, RICS, RPA2, RPL39L, RPP30, RTN2, SAP30, SC4MOL, SC5DL, SCARA3, SCD, SMC2, SMC4, SOX9, SPAG5, SPC25, SQLE, SREBF1, SREBF2, SRF, ST3GAL1, STMN1, STX6, SUPT16H, SUV39H1, TCEA2, TELO2, TFDP1, TIMELESS, TIPIN, TM7SF2, TMEM106C, TMEM48, TMPO, TNS3, TOP2A, TOPBP1, TPX2, TRMT5, TTF2, TTK, TUBGCP5, UBE2C, UST, VEGFA, WDHD1, WEE1, WNT2, ZWILCH, ZWINT	2705	organelle part
GO:0005856	3.448e-05	47.96	82 ALDOC, ANK2, ARHGAP26, ARHGAP6, AURKA, AURKB, BRCA1, BRCA2, BUB1, BUB1B, C13orf15, C18orf24, CCNB1, CCNB2, CDC2, CDC20, CDC25B, CDC45L, CDC6, CDK5RAP2, CENPE, CENPF, CENPJ, CEP192, CEP97, CKAP2, CP110, CSTA, CTSO, DLGAP5, DMD, DPYSL2, ESPL1, FAM29A, FBXO5, FGFR1OP, FHL3, GABARAPL1, GABARAPL3, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, KNTC1, KRTAP1-1, LMNB1, LMNB2, LYST, MDC1, MYC, MYL5, MYO19, MYO1E, NCAPH, NDRG1, NEDD9, NEK2, NUP85, NUSAP1, PCNT, PLK1, PPL, PRC1, PSRC1, RACGAP1, SNTB1, SPAG5, STMN1, TOP2A, TPX2, TTK, TUBGCP5, VCL	699	cytoskeleton
GO:0043596	1.005e-04	0.7548	7 MCM3, MCM7, POLA1, POLA2, POLD3, PRIM1, RPA2	11	nuclear replication fork
GO:0005874	3.490e-04	10.16	26 CDC2, CENPE, CENPJ, CKAP2, GABARAPL1, GABARAPL3, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, KNTC1, NUSAP1, PRC1, RACGAP1, SPAG5, STMN1, TUBGCP5	148	microtubule
GO:0030894	3.495e-04	0.6176	6 MCM3, POLA1, POLA2, POLD3, PRIM1, RPA2	9	replisome
GO:0043601	3.495e-04	0.6176	6 MCM3, POLA1, POLA2, POLD3, PRIM1, RPA2	9	nuclear replisome
GO:0044454	9.217e-04	3.911	14 BLM, BUB1, MCM2, MCM3, MCM7, NCAPD3, ORC6L, POLA1, POLA2, POLD3, PRIM1, RPA2, TIMELESS, TIPIN	57	nuclear chromosome part
GO:0005815	2.075e-03	10.7	25 AURKA, BRCA1, BRCA2, BUB1, C13orf15, CCNB1, CDC25B, CDC45L, CDK5RAP2, CENPJ, CEP192, CEP97, CP110, DLGAP5, ESPL1, FAM29A, FGFR1OP, KIF15, KIF20B, KIFC1, NEK2, PCNT, PLK1, TOP2A, TUBGCP5	156	microtubule organizing center
GO:0005658	3.653e-03	0.3431	4 MCM3, POLA1, POLA2, PRIM1	5	alpha DNA polymerase:primase complex
GO:0043233	5.847e-03	73.83	103 ANGPTL4, ATF3, BACH1, BIRC5, BLM, BRCA1, BRCA2, C14orf106, CASP1, CBS, CCNA2, CCNB1, CCNE1, CCNE2, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CKS1B, CSTF2, DBF4, DDX11, DNA2, E2F8, EXOSC9, EZH2, FBXO5, GMNN, H6PD, HMGB2, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, LOC81691, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDC1, MKI67, MRE11A, MYBL1, MYC, NFKB1, NR3C1, NR4A1, OIP5, ORC1L, ORC6L, PARP2, PDGFA, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRIM1, PRKG1, RAD51, RAD9A, RBL1, RFC2, RFC3, RFC4, RGS7, RPA2, RPP30, SAP30, SOX9, SRF, SUPT16H, SUV39H1, TCEA2, TFDP1, TNS3, TOP2A, TOPBP1, TRMT5, TTF2, UBE2C, VEGFA, WDHD1, WEE1	1076	organelle lumen
GO:0005813	7.352e-03	10.36	23 AURKA, BRCA2, C13orf15, CCNB1, CDC25B, CDC45L, CDK5RAP2, CENPJ, CEP192, CEP97, CP110, DLGAP5, ESPL1, FAM29A, FGFR1OP, KIF15, KIF20B, KIFC1, NEK2, PCNT, PLK1, TOP2A, TUBGCP5	151	centrosome
GO:0070013	7.573e-03	72.67	101 ANGPTL4, ATF3, BACH1, BIRC5, BLM, BRCA1, BRCA2, C14orf106, CASP1, CBS, CCNA2, CCNB1, CCNE1, CCNE2, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CKS1B, CSTF2, DBF4, DDX11, DNA2, E2F8, EXOSC9, EZH2, FBXO5, GMNN, H6PD, HMGB2, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, LOC81691, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDC1, MKI67, MRE11A, MYBL1, MYC, NFKB1, NR3C1, NR4A1, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRIM1, PRKG1, RAD51, RAD9A, RBL1, RFC2, RFC3, RFC4, RGS7, RPA2, RPP30, SAP30, SOX9, SRF, SUPT16H, SUV39H1, TCEA2, TFDP1, TNS3, TOP2A, TOPBP1, TRMT5, TTF2, UBE2C, WDHD1, WEE1	1059	intracellular organelle lumen
GO:0000794	7.656e-03	1.372	7 BLM, BUB1, CHEK1, DMC1, NCAPD3, SUV39H1, TOPBP1	20	condensed nuclear chromosome
GO:0000922	7.656e-03	1.372	7 BUB1, CENPF, DLGAP5, KIF11, KNTC1, TPX2, TUBGCP5	20	spindle pole
GO:0031974	8.511e-03	75.55	104 ANGPTL4, ATF3, BACH1, BIRC5, BLM, BRCA1, BRCA2, C14orf106, CASP1, CBS, CCNA2, CCNB1, CCNE1, CCNE2, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CKS1B, CSTF2, DBF4, DDX11, DNA2, E2F8, EXOSC9, EZH2, FBXO5, GMNN, H6PD, HMGB2, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, LOC81691, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDC1, MKI67, MRE11A, MYBL1, MYC, NFKB1, NR3C1, NR4A1, OIP5, ORC1L, ORC6L, PARP2, PDGFA, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, POLR2D, PRIM1, PRKG1, PTGES, RAD51, RAD9A, RBL1, RFC2, RFC3, RFC4, RGS7, RPA2, RPP30, SAP30, SOX9, SRF, SUPT16H, SUV39H1, TCEA2, TFDP1, TNS3, TOP2A, TOPBP1, TRMT5, TTF2, UBE2C, VEGFA, WDHD1, WEE1	1101	membrane-enclosed lumen
GO:0000940	9.765e-03	0.2059	3 BUB1B, CENPE, CENPF	3	outer kinetochore of condensed chromosome
GO:0005876	2.406e-02	1.235	6 CDC2, KIF11, KIF4A, KNTC1, PRC1, SPAG5	18	spindle microtubule
GO:0005875	3.663e-02	4.529	12 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A	66	microtubule associated complex

Id	Pvalue	ExpCount	Count	Size	Term
GO:0008094	4.730e-05	2.577	14 BLM, BRIP1, DDX11, DDX12, DMC1, DNA2, RAD51, RAD51L1, RAD54B, RFC2, RFC3, RFC4, TOP2A, TTF2	39	DNA-dependent ATPase activity
GO:0003777	1.324e-04	2.445	13 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1	37	microtubule motor activity
GO:0005524	5.486e-04	53.47	87 ABCA5, ACACA, ATAD2, ATAD5, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC2, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, DCLK1, DDX11, DDX12, DMC1, DNA2, DTYMK, EPHB6, ERCC6L, HELLS, HSPA12A, IFIH1, ITPKC, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, LIG1, MAP3K8, MCM2, MCM3, MCM5, MCM7, MELK, MKI67, MSH2, MVD, MYO19, MYO1E, NEK2, NME5, ORC1L, PANK3, PDGFRB, PKMYT1, PLK1, PLK4, POLQ, PRKG1, RAD51L1, RAD54B, RAD54L, RFC2, RFC4, ROR1, RRM1, SGK1, SKIV2L, SMC2, SMC4, STK38L, TGFBR1, TK1, TOP2A, TPX2, TRIB1, TRIP13, TTF2, TTK, UBA7, UBE2C, VRK1, WEE1	809	ATP binding
GO:0030554	7.023e-04	57.1	91 ABCA5, ACACA, ACADVL, ATAD2, ATAD5, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC2, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, DCLK1, DDX11, DDX12, DHCR24, DMC1, DNA2, DTYMK, EPHB6, ERCC6L, GALNAC4S-6ST, HELLS, HSPA12A, IFIH1, ITPKC, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, LIG1, MAP3K8, MCM2, MCM3, MCM5, MCM7, MELK, MKI67, MSH2, MVD, MYO19, MYO1E, NEK2, NME5, ORC1L, PANK3, PDGFRB, PKMYT1, PLK1, PLK4, POLQ, PRKG1, RAD51L1, RAD54B, RAD54L, RFC2, RFC4, ROR1, RRM1, SGK1, SKIV2L, SMC2, SMC4, SQLE, STK38L, TGFBR1, TK1, TOP2A, TPX2, TRIB1, TRIP13, TTF2, TTK, UBA7, UBE2C, VRK1, WEE1	864	adenyl nucleotide binding
GO:0032559	7.924e-04	54.06	87 ABCA5, ACACA, ATAD2, ATAD5, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC2, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, DCLK1, DDX11, DDX12, DMC1, DNA2, DTYMK, EPHB6, ERCC6L, HELLS, HSPA12A, IFIH1, ITPKC, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, LIG1, MAP3K8, MCM2, MCM3, MCM5, MCM7, MELK, MKI67, MSH2, MVD, MYO19, MYO1E, NEK2, NME5, ORC1L, PANK3, PDGFRB, PKMYT1, PLK1, PLK4, POLQ, PRKG1, RAD51L1, RAD54B, RAD54L, RFC2, RFC4, ROR1, RRM1, SGK1, SKIV2L, SMC2, SMC4, STK38L, TGFBR1, TK1, TOP2A, TPX2, TRIB1, TRIP13, TTF2, TTK, UBA7, UBE2C, VRK1, WEE1	818	adenyl ribonucleotide binding
GO:0003677	8.443e-04	79.97	118 ANG, ATAD2, ATF3, BACH1, BLM, BNC1, BRCA1, BRCA2, BRIP1, C12orf48, C14orf106, CENPA, CENPC1, CREB5, DDX11, DDX12, DEK, DMC1, DNA2, DSCC1, E2F8, EGR2, ERCC6L, EXO1, EZH2, FANCG, FEN1, FOSB, FOXM1, HELLS, HIVEP1, HIVEP2, HJURP, HMGB1L10, HMGB2, HMGB3, HNRNPA2B1, HOXA10, HOXA9, IFIH1, IRF7, JARID1B, JARID2, JMJD3, KIF15, KIF22, KIF2C, KIF4A, KLF13, KLF7, LHFP, LIG1, MAFF, MCM2, MCM3, MCM4, MCM5, MCM7, MLXIP, MRE11A, MSC, MSH2, MYBL1, MYBL2, MYC, NCOA1, NEIL3, NFATC1, NFIL3, NFKB1, NR3C1, NR4A1, NR4A2, NR4A3, NUSAP1, ORC1L, ORC6L, PARP2, PEG10, POLA1, POLA2, POLD1, POLE, POLE2, POLQ, PSMC3IP, PTTG1, RAD51, RAD51AP1, RAD51L1, RAD54B, RAD54L, REL, RELB, RFC2, RFC3, RFC4, RLF, RPA2, RUNX1, SOX9, SREBF1, SREBF2, SRF, TCEA2, TFDP1, THAP10, TMPO, TOP2A, TOPBP1, TRPS1, TSC22D3, TTF2, VDR, WDHD1, WHSC1, ZNF394, ZNF85	1210	DNA binding
GO:0004527	1.903e-03	2.313	11 DCLRE1C, DIS3, ERI2, EXO1, EXOSC9, FEN1, LOC81691, MRE11A, POLD1, RAD9A, TDP1	35	exonuclease activity
GO:0003774	2.223e-03	4.692	16 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, MYL5, MYO19, MYO1E	71	motor activity
GO:0003887	1.105e-02	1.19	7 POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ	18	DNA-directed DNA polymerase activity
GO:0017076	1.575e-02	70.05	99 ABCA5, ACACA, ACADVL, ARHGAP5, ATAD2, ATAD5, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC2, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, DCLK1, DDX11, DDX12, DHCR24, DMC1, DNA2, DTYMK, EPHB6, ERCC6L, GALNAC4S-6ST, GCH1, HELLS, HSPA12A, IFIH1, ITPKC, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, LIG1, MAP3K8, MCM2, MCM3, MCM5, MCM7, MELK, MKI67, MSH2, MVD, MX1, MX2, MYO19, MYO1E, NEK2, NME5, ORC1L, PANK3, PCK2, PDGFRB, PKMYT1, PLK1, PLK4, POLQ, PRKG1, RAB33A, RAD51L1, RAD54B, RAD54L, RFC2, RFC4, RHOQ, ROR1, RRAGB, RRM1, SGK1, SKIV2L, SMC2, SMC4, SQLE, STK38L, TGFBR1, TK1, TOP2A, TPX2, TRIB1, TRIP13, TTF2, TTK, UBA7, UBE2C, VRK1, WEE1	1060	purine nucleotide binding
GO:0032553	1.759e-02	66.88	95 ABCA5, ACACA, ARHGAP5, ATAD2, ATAD5, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC2, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, DCLK1, DDX11, DDX12, DMC1, DNA2, DTYMK, EPHB6, ERCC6L, GCH1, HELLS, HSPA12A, IFIH1, ITPKC, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, LIG1, MAP3K8, MCM2, MCM3, MCM5, MCM7, MELK, MKI67, MSH2, MVD, MX1, MX2, MYO19, MYO1E, NEK2, NME5, ORC1L, PANK3, PCK2, PDGFRB, PKMYT1, PLK1, PLK4, POLQ, PRKG1, RAB33A, RAD51L1, RAD54B, RAD54L, RFC2, RFC4, RHOQ, ROR1, RRAGB, RRM1, SGK1, SKIV2L, SMC2, SMC4, STK38L, TGFBR1, TK1, TOP2A, TPX2, TRIB1, TRIP13, TTF2, TTK, UBA7, UBE2C, VRK1, WEE1	1012	ribonucleotide binding
GO:0032555	1.759e-02	66.88	95 ABCA5, ACACA, ARHGAP5, ATAD2, ATAD5, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC2, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, DCLK1, DDX11, DDX12, DMC1, DNA2, DTYMK, EPHB6, ERCC6L, GCH1, HELLS, HSPA12A, IFIH1, ITPKC, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, LIG1, MAP3K8, MCM2, MCM3, MCM5, MCM7, MELK, MKI67, MSH2, MVD, MX1, MX2, MYO19, MYO1E, NEK2, NME5, ORC1L, PANK3, PCK2, PDGFRB, PKMYT1, PLK1, PLK4, POLQ, PRKG1, RAB33A, RAD51L1, RAD54B, RAD54L, RFC2, RFC4, RHOQ, ROR1, RRAGB, RRM1, SGK1, SKIV2L, SMC2, SMC4, STK38L, TGFBR1, TK1, TOP2A, TPX2, TRIB1, TRIP13, TTF2, TTK, UBA7, UBE2C, VRK1, WEE1	1012	purine ribonucleotide binding
GO:0003697	2.045e-02	2.644	10 BLM, BRCA2, HMGB2, HNRNPA2B1, MCM4, MCM7, MSH2, RAD51, RAD51AP1, RPA2	40	single-stranded DNA binding
GO:0016717	2.428e-02	0.3965	4 FADS1, FADS2, SC5DL, SCD	6	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0034061	2.539e-02	1.388	7 POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ	21	DNA polymerase activity
GO:0016817	2.690e-02	31.26	51 ABCA5, ACYP1, ARHGAP5, ATAD2, ATAD5, ATP6V1G2, BLM, BRIP1, CDC6, CENPE, DDX11, DDX12, DMC1, DNA2, ERCC6L, HELLS, IFIH1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, MCM3, MCM4, MCM7, MSH2, MX1, MX2, MYL5, MYO19, MYO1E, ORC1L, RAB33A, RAD51, RAD51L1, RAD54B, RAD54L, RFC2, RFC3, RFC4, SKIV2L, TOP2A, TRIP13, TTF2	473	hydrolase activity, acting on acid anhydrides
GO:0017111	2.882e-02	29.81	49 ABCA5, ARHGAP5, ATAD2, ATAD5, BLM, BRIP1, CDC6, CENPE, DDX11, DDX12, DMC1, DNA2, ERCC6L, HELLS, IFIH1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, MCM3, MCM4, MCM7, MSH2, MX1, MX2, MYL5, MYO19, MYO1E, ORC1L, RAB33A, RAD51, RAD51L1, RAD54B, RAD54L, RFC2, RFC3, RFC4, SKIV2L, TOP2A, TRIP13, TTF2	451	nucleoside-triphosphatase activity
GO:0000166	3.191e-02	84.26	113 ABCA5, ACACA, ACADVL, ARHGAP5, ATAD2, ATAD5, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC2, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, CSTF2, DCLK1, DDX11, DDX12, DHCR24, DHRS3, DMC1, DNA2, DTYMK, ENOX1, EPHB6, ERCC6L, GALNAC4S-6ST, GCH1, HELLS, HNRNPA2B1, HSPA12A, IFIH1, ITPKC, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, LIG1, LOC81691, MAP3K8, MCM2, MCM3, MCM4, MCM5, MCM7, MELK, MKI67, MSH2, MVD, MX1, MX2, MYO19, MYO1E, NEK2, NME5, ORC1L, PANK3, PBK, PCK2, PDGFRB, PKMYT1, PLK1, PLK4, POLA1, POLD1, POLE, POLQ, POLR2D, PRKG1, RAB33A, RAD51, RAD51L1, RAD54B, RAD54L, RFC2, RFC3, RFC4, RHOQ, ROR1, RRAGB, RRM1, SGK1, SKIL, SKIV2L, SMC2, SMC4, SQLE, STK38L, TGFBR1, TK1, TOP2A, TPX2, TRIB1, TRIP13, TTF2, TTK, UBA7, UBE2C, VRK1, WEE1	1275	nucleotide binding
GO:0016818	3.940e-02	31.19	50 ABCA5, ACYP1, ARHGAP5, ATAD2, ATAD5, BLM, BRIP1, CDC6, CENPE, DDX11, DDX12, DMC1, DNA2, ERCC6L, HELLS, IFIH1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KIFC1, MCM3, MCM4, MCM7, MSH2, MX1, MX2, MYL5, MYO19, MYO1E, ORC1L, RAB33A, RAD51, RAD51L1, RAD54B, RAD54L, RFC2, RFC3, RFC4, SKIV2L, TOP2A, TRIP13, TTF2	472	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Id	Pvalue	ExpCount	Count	Size	Term
04110	6.223e-12	7.765	34 BUB1, BUB1B, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDKN2D, CHEK1, DBF4, ESPL1, MAD2L1, MCM2, MCM3, MCM4, MCM5, MCM7, ORC1L, ORC6L, PKMYT1, PLK1, PTTG1, RBL1, TFDP1, WEE1	98	Cell cycle
03030	6.223e-12	2.615	20 DNA2, FEN1, LIG1, MCM2, MCM3, MCM4, MCM5, MCM7, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, PRIM1, RFC2, RFC3, RFC4, RNASEH2A, RPA2	33	DNA replication
00100	3.993e-08	1.822	14 CYP51A1, DHCR24, DHCR7, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, NSDHL, SC4MOL, SC5DL, SQLE, TM7SF2	23	Biosynthesis of steroids
03440	1.286e-03	1.981	10 BLM, BRCA2, MRE11A, POLD1, POLD3, RAD51, RAD51L1, RAD54B, RAD54L, RPA2	25	Homologous recombination
03430	2.600e-03	1.743	9 EXO1, LIG1, MSH2, POLD1, POLD3, RFC2, RFC3, RFC4, RPA2	22	Mismatch repair
03410	6.095e-03	2.377	10 FEN1, HMGB1L10, LIG1, NEIL3, PARP2, POLD1, POLD3, POLE, POLE2, UNG	30	Base excision repair

No enriched terms

No enriched terms

Entrez genes

ABCA5ATP-binding cassette, sub-family A (ABC1), member 5 (213353_at), score: -0.78 ABHD10abhydrolase domain containing 10 (218633_x_at), score: 0.6 ACACAacetyl-Coenzyme A carboxylase alpha (212186_at), score: -0.62 ACADVLacyl-Coenzyme A dehydrogenase, very long chain (200710_at), score: 0.5 ACYP1acylphosphatase 1, erythrocyte (common) type (205260_s_at), score: 0.59 ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 5 (219935_at), score: -0.66 ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide (209612_s_at), score: -0.59 ADIPOR2adiponectin receptor 2 (201346_at), score: -0.68 AGTR1angiotensin II receptor, type 1 (205357_s_at), score: -0.68 ALDH6A1aldehyde dehydrogenase 6 family, member A1 (221589_s_at), score: -0.63 ALDOCaldolase C, fructose-bisphosphate (202022_at), score: -0.66 ANGangiogenin, ribonuclease, RNase A family, 5 (213397_x_at), score: -0.6 ANGPTL2angiopoietin-like 2 (213001_at), score: -0.74 ANGPTL4angiopoietin-like 4 (221009_s_at), score: -0.68 ANK2ankyrin 2, neuronal (202920_at), score: -0.84 ANXA3annexin A3 (209369_at), score: -0.67 APOBEC3Bapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B (206632_s_at), score: 0.59 AQP3aquaporin 3 (Gill blood group) (39248_at), score: -0.68 ARHGAP11ARho GTPase activating protein 11A (204492_at), score: 0.65 ARHGAP19Rho GTPase activating protein 19 (212738_at), score: 0.61 ARHGAP26Rho GTPase activating protein 26 (205068_s_at), score: -0.62 ARHGAP5Rho GTPase activating protein 5 (217936_at), score: -0.63 ARHGAP6Rho GTPase activating protein 6 (206167_s_at), score: -0.57 ARL6IP1ADP-ribosylation factor-like 6 interacting protein 1 (211935_at), score: 0.51 ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (206414_s_at), score: -0.59 ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae) (218115_at), score: 0.71 ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila) (219918_s_at), score: 0.67 ASPNasporin (219087_at), score: -0.69 ATAD2ATPase family, AAA domain containing 2 (218782_s_at), score: 0.63 ATAD5ATPase family, AAA domain containing 5 (220223_at), score: 0.5 ATF3activating transcription factor 3 (202672_s_at), score: -0.68 ATP6V1G2ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 (214762_at), score: -0.71 AURKAaurora kinase A (208079_s_at), score: 0.67 AURKBaurora kinase B (209464_at), score: 0.74 B3GALT2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 (217452_s_at), score: -0.56 B3GNT2UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (219326_s_at), score: -0.72 B4GALT5UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 (221485_at), score: -0.57 BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 1 (204194_at), score: -0.57 BARD1BRCA1 associated RING domain 1 (205345_at), score: 0.72 BBS1Bardet-Biedl syndrome 1 (218471_s_at), score: -0.57 BEX1brain expressed, X-linked 1 (218332_at), score: 0.55 BEX4brain expressed, X-linked 4 (215440_s_at), score: -0.64 BIRC5baculoviral IAP repeat-containing 5 (202095_s_at), score: 0.7 BLMBloom syndrome (205733_at), score: 0.68 BMP2bone morphogenetic protein 2 (205289_at), score: -0.65 BNC1basonuclin 1 (206581_at), score: -0.6 BRCA1breast cancer 1, early onset (204531_s_at), score: 0.69 BRCA2breast cancer 2, early onset (208368_s_at), score: 0.6 BRIP1BRCA1 interacting protein C-terminal helicase 1 (221703_at), score: 0.74 BTG2BTG family, member 2 (201236_s_at), score: -0.57 BUB1budding uninhibited by benzimidazoles 1 homolog (yeast) (209642_at), score: 0.75 BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast) (203755_at), score: 0.72 C12orf48chromosome 12 open reading frame 48 (220060_s_at), score: 0.65 C13orf15chromosome 13 open reading frame 15 (218723_s_at), score: -0.62 C13orf34chromosome 13 open reading frame 34 (219544_at), score: 0.56 C14orf1chromosome 14 open reading frame 1 (202562_s_at), score: -0.74 C14orf106chromosome 14 open reading frame 106 (206500_s_at), score: 0.57 C14orf143chromosome 14 open reading frame 143 (214264_s_at), score: 0.58 C16orf53chromosome 16 open reading frame 53 (218300_at), score: 0.57 C17orf91chromosome 17 open reading frame 91 (214696_at), score: -0.83 C18orf24chromosome 18 open reading frame 24 (217640_x_at), score: 0.75 C19orf66chromosome 19 open reading frame 66 (53720_at), score: -0.57 C1orf112chromosome 1 open reading frame 112 (220840_s_at), score: 0.61 C1orf135chromosome 1 open reading frame 135 (220011_at), score: 0.74 C1orf56chromosome 1 open reading frame 56 (221222_s_at), score: -0.6 C21orf45chromosome 21 open reading frame 45 (219004_s_at), score: 0.78 C4orf15chromosome 4 open reading frame 15 (210054_at), score: 0.55 C4orf18chromosome 4 open reading frame 18 (219872_at), score: -0.78 C9orf40chromosome 9 open reading frame 40 (218904_s_at), score: 0.61 C9orf91chromosome 9 open reading frame 91 (221865_at), score: -0.57 CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (211368_s_at), score: -0.59 CASP2caspase 2, apoptosis-related cysteine peptidase (209811_at), score: 0.56 CBR3carbonyl reductase 3 (205379_at), score: 0.58 CBScystathionine-beta-synthase (212816_s_at), score: -0.59 CCDC15coiled-coil domain containing 15 (220466_at), score: 0.69 CCL11chemokine (C-C motif) ligand 11 (210133_at), score: -0.82 CCNA2cyclin A2 (203418_at), score: 0.72 CCNB1cyclin B1 (214710_s_at), score: 0.62 CCNB2cyclin B2 (202705_at), score: 0.64 CCNE1cyclin E1 (213523_at), score: 0.61 CCNE2cyclin E2 (205034_at), score: 0.74 CCNFcyclin F (204826_at), score: 0.66 CCNJcyclin J (219470_x_at), score: -0.62 CD302CD302 molecule (203799_at), score: -0.57 CDC2cell division cycle 2, G1 to S and G2 to M (203213_at), score: 0.57 CDC20cell division cycle 20 homolog (S. cerevisiae) (202870_s_at), score: 0.69 CDC25Acell division cycle 25 homolog A (S. pombe) (204695_at), score: 0.68 CDC25Bcell division cycle 25 homolog B (S. pombe) (201853_s_at), score: 0.51 CDC25Ccell division cycle 25 homolog C (S. pombe) (205167_s_at), score: 0.62 CDC45LCDC45 cell division cycle 45-like (S. cerevisiae) (204126_s_at), score: 0.73 CDC6cell division cycle 6 homolog (S. cerevisiae) (203967_at), score: 0.75 CDC7cell division cycle 7 homolog (S. cerevisiae) (204510_at), score: 0.8 CDCA3cell division cycle associated 3 (221436_s_at), score: 0.68 CDCA4cell division cycle associated 4 (218399_s_at), score: 0.62 CDCA8cell division cycle associated 8 (221520_s_at), score: 0.74 CDK2cyclin-dependent kinase 2 (204252_at), score: 0.78 CDK5RAP2CDK5 regulatory subunit associated protein 2 (220935_s_at), score: 0.52 CDKN2AIPCDKN2A interacting protein (218929_at), score: 0.51 CDKN2Dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) (210240_s_at), score: 0.51 CDKN3cyclin-dependent kinase inhibitor 3 (209714_s_at), score: 0.63 CDT1chromatin licensing and DNA replication factor 1 (209832_s_at), score: 0.7 CDYLchromodomain protein, Y-like (203100_s_at), score: -0.71 CENPAcentromere protein A (204962_s_at), score: 0.69 CENPC1centromere protein C 1 (204739_at), score: 0.51 CENPEcentromere protein E, 312kDa (205046_at), score: 0.72 CENPFcentromere protein F, 350/400ka (mitosin) (207828_s_at), score: 0.71 CENPIcentromere protein I (214804_at), score: 0.71 CENPJcentromere protein J (220885_s_at), score: 0.56 CENPMcentromere protein M (218741_at), score: 0.77 CENPOcentromere protein O (219472_at), score: 0.59 CENPQcentromere protein Q (219294_at), score: 0.67 CEP192centrosomal protein 192kDa (218827_s_at), score: 0.55 CEP55centrosomal protein 55kDa (218542_at), score: 0.62 CEP97centrosomal protein 97kDa (219886_at), score: 0.58 CHAF1Achromatin assembly factor 1, subunit A (p150) (214426_x_at), score: 0.73 CHAF1Bchromatin assembly factor 1, subunit B (p60) (204775_at), score: 0.7 CHEK1CHK1 checkpoint homolog (S. pombe) (205393_s_at), score: 0.62 CITcitron (rho-interacting, serine/threonine kinase 21) (212801_at), score: 0.69 CKAP2cytoskeleton associated protein 2 (218252_at), score: 0.75 CKS1BCDC28 protein kinase regulatory subunit 1B (201897_s_at), score: 0.53 CLCN6chloride channel 6 (203950_s_at), score: -0.7 CLEC3BC-type lectin domain family 3, member B (205200_at), score: -0.56 COL14A1collagen, type XIV, alpha 1 (212865_s_at), score: -0.82 COL16A1collagen, type XVI, alpha 1 (204345_at), score: -0.55 COL21A1collagen, type XXI, alpha 1 (208096_s_at), score: -0.86 CORINcorin, serine peptidase (220356_at), score: -0.78 CP110CP110 protein (204662_at), score: 0.55 CPA3carboxypeptidase A3 (mast cell) (205624_at), score: -0.93 CPA4carboxypeptidase A4 (205832_at), score: -0.72 CREB5cAMP responsive element binding protein 5 (205931_s_at), score: -0.67 CSGALNACT1chondroitin sulfate N-acetylgalactosaminyltransferase 1 (219049_at), score: 0.52 CSTAcystatin A (stefin A) (204971_at), score: -0.62 CSTF2cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa (204459_at), score: 0.61 CTSFcathepsin F (203657_s_at), score: -0.56 CTSOcathepsin O (203758_at), score: -0.61 CXCL3chemokine (C-X-C motif) ligand 3 (207850_at), score: -0.62 CXCR7chemokine (C-X-C motif) receptor 7 (212977_at), score: -0.73 CYFIP2cytoplasmic FMR1 interacting protein 2 (215785_s_at), score: -0.56 CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1 (216607_s_at), score: -0.7 DAAM2dishevelled associated activator of morphogenesis 2 (212793_at), score: -0.62 DACT1dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) (219179_at), score: -0.62 DBF4DBF4 homolog (S. cerevisiae) (204244_s_at), score: 0.57 DCLK1doublecortin-like kinase 1 (205399_at), score: -0.58 DCLRE1BDNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) (219490_s_at), score: 0.58 DCLRE1CDNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) (222233_s_at), score: 0.5 DCP1ADCP1 decapping enzyme homolog A (S. cerevisiae) (218508_at), score: -0.59 DDX11DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) (208149_x_at), score: 0.69 DDX12DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 (CHL1-like helicase homolog, S. cerevisiae) (213378_s_at), score: 0.58 DEKDEK oncogene (200934_at), score: 0.49 DEPDC1DEP domain containing 1 (220295_x_at), score: 0.76 DHCR2424-dehydrocholesterol reductase (200862_at), score: -0.56 DHCR77-dehydrocholesterol reductase (201790_s_at), score: -0.91 DHFRdihydrofolate reductase (202533_s_at), score: 0.69 DHRS12dehydrogenase/reductase (SDR family) member 12 (204800_s_at), score: -0.61 DHRS3dehydrogenase/reductase (SDR family) member 3 (202481_at), score: -0.67 DIS3DIS3 mitotic control homolog (S. cerevisiae) (218362_s_at), score: -0.56 DKFZP586H2123regeneration associated muscle protease (213661_at), score: -0.58 DLEU2deleted in lymphocytic leukemia 2 (non-protein coding) (216870_x_at), score: 0.71 DLEU2Ldeleted in lymphocytic leukemia 2-like (215629_s_at), score: 0.75 DLGAP5discs, large (Drosophila) homolog-associated protein 5 (203764_at), score: 0.68 DMC1DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) (208382_s_at), score: 0.57 DMDdystrophin (203881_s_at), score: -0.7 DNA2DNA replication helicase 2 homolog (yeast) (213647_at), score: 0.58 DNAJC9DnaJ (Hsp40) homolog, subfamily C, member 9 (213092_x_at), score: 0.54 DPY19L2P2dpy-19-like 2 pseudogene 2 (C. elegans) (215143_at), score: 0.53 DPYSL2dihydropyrimidinase-like 2 (200762_at), score: -0.67 DRAMdamage-regulated autophagy modulator (218627_at), score: -0.69 DSCC1defective in sister chromatid cohesion 1 homolog (S. cerevisiae) (219000_s_at), score: 0.67 DSN1DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) (219512_at), score: 0.88 DTLdenticleless homolog (Drosophila) (218585_s_at), score: 0.73 DTYMKdeoxythymidylate kinase (thymidylate kinase) (203270_at), score: 0.53 DVL3dishevelled, dsh homolog 3 (Drosophila) (201908_at), score: -0.7 E2F8E2F transcription factor 8 (219990_at), score: 0.67 ECM2extracellular matrix protein 2, female organ and adipocyte specific (206101_at), score: -0.78 ECT2epithelial cell transforming sequence 2 oncogene (219787_s_at), score: 0.5 EGR2early growth response 2 (Krox-20 homolog, Drosophila) (205249_at), score: -0.67 ENOX1ecto-NOX disulfide-thiol exchanger 1 (219501_at), score: -0.69 ENTPD7ectonucleoside triphosphate diphosphohydrolase 7 (220153_at), score: -0.67 EPHB6EPH receptor B6 (204718_at), score: -0.62 ERCC6Lexcision repair cross-complementing rodent repair deficiency, complementation group 6-like (219650_at), score: 0.73 ERI2exoribonuclease 2 (213365_at), score: 0.7 ESPL1extra spindle pole bodies homolog 1 (S. cerevisiae) (38158_at), score: 0.56 EVCEllis van Creveld syndrome (219432_at), score: -0.6 EXO1exonuclease 1 (204603_at), score: 0.71 EXOSC9exosome component 9 (205061_s_at), score: 0.73 EZH2enhancer of zeste homolog 2 (Drosophila) (203358_s_at), score: 0.82 F10coagulation factor X (205620_at), score: -0.57 FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (214285_at), score: -1 FADS1fatty acid desaturase 1 (208962_s_at), score: -0.79 FADS2fatty acid desaturase 2 (202218_s_at), score: -0.73 FAM111Afamily with sequence similarity 111, member A (218248_at), score: 0.58 FAM29Afamily with sequence similarity 29, member A (218602_s_at), score: 0.54 FAM64Afamily with sequence similarity 64, member A (221591_s_at), score: 0.69 FANCAFanconi anemia, complementation group A (203805_s_at), score: 0.62 FANCGFanconi anemia, complementation group G (203564_at), score: 0.71 FANCIFanconi anemia, complementation group I (213007_at), score: 0.65 FBXO5F-box protein 5 (218875_s_at), score: 0.57 FBXW7F-box and WD repeat domain containing 7 (218751_s_at), score: -0.66 FCGRTFc fragment of IgG, receptor, transporter, alpha (218831_s_at), score: -0.61 FEN1flap structure-specific endonuclease 1 (204767_s_at), score: 0.59 FGFR1OPFGFR1 oncogene partner (205588_s_at), score: 0.51 FHL3four and a half LIM domains 3 (218818_at), score: -0.57 FOSBFBJ murine osteosarcoma viral oncogene homolog B (202768_at), score: -0.62 FOXM1forkhead box M1 (202580_x_at), score: 0.63 FRYfurry homolog (Drosophila) (204072_s_at), score: -0.89 GAB2GRB2-associated binding protein 2 (203853_s_at), score: -0.61 GABARAPL1GABA(A) receptor-associated protein like 1 (208868_s_at), score: -0.73 GABARAPL3GABA(A) receptors associated protein like 3 (pseudogene) (211458_s_at), score: -0.7 GALEUDP-galactose-4-epimerase (202528_at), score: 0.6 GALNAC4S-6STB cell RAG associated protein (203066_at), score: -0.82 GCH1GTP cyclohydrolase 1 (204224_s_at), score: -0.74 GDF15growth differentiation factor 15 (221577_x_at), score: -0.7 GDPD5glycerophosphodiester phosphodiesterase domain containing 5 (32502_at), score: -0.69 GFPT2glutamine-fructose-6-phosphate transaminase 2 (205100_at), score: -0.67 GINS1GINS complex subunit 1 (Psf1 homolog) (206102_at), score: 0.72 GINS2GINS complex subunit 2 (Psf2 homolog) (221521_s_at), score: 0.76 GINS3GINS complex subunit 3 (Psf3 homolog) (45633_at), score: 0.77 GINS4GINS complex subunit 4 (Sld5 homolog) (211767_at), score: 0.67 GLAgalactosidase, alpha (214430_at), score: 0.55 GLTSCR2glioma tumor suppressor candidate region gene 2 (217807_s_at), score: -0.55 GMNNgeminin, DNA replication inhibitor (218350_s_at), score: 0.66 GOLGB1golgin B1, golgi integral membrane protein (201057_s_at), score: -0.56 GPD2glycerol-3-phosphate dehydrogenase 2 (mitochondrial) (210007_s_at), score: 0.64 GPR183G protein-coupled receptor 183 (205419_at), score: -0.61 GPR37G protein-coupled receptor 37 (endothelin receptor type B-like) (209631_s_at), score: -0.6 GRAMD1CGRAM domain containing 1C (219313_at), score: 0.54 GRIA3glutamate receptor, ionotrophic, AMPA 3 (206730_at), score: -0.66 GSTM1glutathione S-transferase mu 1 (204550_x_at), score: -0.67 GSTM2glutathione S-transferase mu 2 (muscle) (204418_x_at), score: -0.64 GSTM5glutathione S-transferase mu 5 (205752_s_at), score: -0.66 GTSE1G-2 and S-phase expressed 1 (204318_s_at), score: 0.71 H6PDhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (221892_at), score: -0.6 HCFC1R1host cell factor C1 regulator 1 (XPO1 dependent) (45714_at), score: -0.55 HELLShelicase, lymphoid-specific (220085_at), score: 0.74 HERC6hect domain and RLD 6 (219352_at), score: -0.75 HIRIP3HIRA interacting protein 3 (204504_s_at), score: 0.6 HIST1H1Chistone cluster 1, H1c (209398_at), score: 0.53 HIST1H2BGhistone cluster 1, H2bg (210387_at), score: 0.51 HIVEP1human immunodeficiency virus type I enhancer binding protein 1 (204512_at), score: -0.78 HIVEP2human immunodeficiency virus type I enhancer binding protein 2 (212642_s_at), score: -0.6 HJURPHolliday junction recognition protein (218726_at), score: 0.72 HMGB1L10high-mobility group box 1-like 10 (216508_x_at), score: 0.51 HMGB2high-mobility group box 2 (208808_s_at), score: 0.66 HMGB3high-mobility group box 3 (203744_at), score: 0.56 HMGCR3-hydroxy-3-methylglutaryl-Coenzyme A reductase (202540_s_at), score: -0.74 HMGCS13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) (221750_at), score: -0.76 HMMRhyaluronan-mediated motility receptor (RHAMM) (207165_at), score: 0.67 HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B1 (205292_s_at), score: 0.5 HOXA10homeobox A10 (213150_at), score: 0.5 HOXA9homeobox A9 (214651_s_at), score: 0.54 HSD17B2hydroxysteroid (17-beta) dehydrogenase 2 (204818_at), score: -0.71 HSD17B7hydroxysteroid (17-beta) dehydrogenase 7 (220081_x_at), score: -0.67 HSPA12Aheat shock 70kDa protein 12A (214434_at), score: -0.59 HSPB3heat shock 27kDa protein 3 (206375_s_at), score: -0.61 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: -0.83 IDH1isocitrate dehydrogenase 1 (NADP+), soluble (201193_at), score: -0.57 IDI1isopentenyl-diphosphate delta isomerase 1 (204615_x_at), score: -0.86 IDI2isopentenyl-diphosphate delta isomerase 2 (217631_at), score: -0.61 IFI35interferon-induced protein 35 (209417_s_at), score: -0.57 IFI44Linterferon-induced protein 44-like (204439_at), score: -0.6 IFIH1interferon induced with helicase C domain 1 (219209_at), score: -0.55 IL1Ainterleukin 1, alpha (210118_s_at), score: -0.73 IL1Binterleukin 1, beta (39402_at), score: -0.76 IL6interleukin 6 (interferon, beta 2) (205207_at), score: -0.77 IL7Rinterleukin 7 receptor (205798_at), score: 0.49 INSIG1insulin induced gene 1 (201627_s_at), score: -0.96 IRF7interferon regulatory factor 7 (208436_s_at), score: -0.59 ITGB3BPintegrin beta 3 binding protein (beta3-endonexin) (205176_s_at), score: 0.67 ITPKCinositol 1,4,5-trisphosphate 3-kinase C (213076_at), score: -0.56 JARID1Bjumonji, AT rich interactive domain 1B (201549_x_at), score: -0.6 JARID2jumonji, AT rich interactive domain 2 (203297_s_at), score: -0.56 JHDM1Djumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (221778_at), score: -0.73 JMJD3jumonji domain containing 3, histone lysine demethylase (213146_at), score: -0.61 KCNB1potassium voltage-gated channel, Shab-related subfamily, member 1 (211006_s_at), score: -0.73 KCND3potassium voltage-gated channel, Shal-related subfamily, member 3 (213832_at), score: -0.9 KIAA0586KIAA0586 (205631_at), score: 0.62 KIAA1644KIAA1644 (52837_at), score: -0.56 KIF11kinesin family member 11 (204444_at), score: 0.72 KIF14kinesin family member 14 (206364_at), score: 0.75 KIF15kinesin family member 15 (219306_at), score: 0.72 KIF18Akinesin family member 18A (221258_s_at), score: 0.7 KIF18Bkinesin family member 18B (222039_at), score: 0.82 KIF20Akinesin family member 20A (218755_at), score: 0.59 KIF20Bkinesin family member 20B (205235_s_at), score: 0.69 KIF22kinesin family member 22 (202183_s_at), score: 0.68 KIF23kinesin family member 23 (204709_s_at), score: 0.61 KIF2Ckinesin family member 2C (209408_at), score: 0.72 KIF4Akinesin family member 4A (218355_at), score: 0.76 KIFC1kinesin family member C1 (209680_s_at), score: 0.58 KLF13Kruppel-like factor 13 (219878_s_at), score: -0.56 KLF7Kruppel-like factor 7 (ubiquitous) (204334_at), score: -0.76 KNTC1kinetochore associated 1 (206316_s_at), score: 0.72 KRTAP1-1keratin associated protein 1-1 (220976_s_at), score: 0.51 LAMC2laminin, gamma 2 (202267_at), score: -0.55 LDLRlow density lipoprotein receptor (202068_s_at), score: -0.71 LHFPlipoma HMGIC fusion partner (218656_s_at), score: -0.56 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: -0.66 LIG1ligase I, DNA, ATP-dependent (202726_at), score: 0.67 LMBRD1LMBR1 domain containing 1 (218191_s_at), score: -0.59 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: -0.83 LMNB1lamin B1 (203276_at), score: 0.73 LMNB2lamin B2 (216952_s_at), score: 0.51 LOC730101hypothetical LOC730101 (213248_at), score: 0.52 LOC81691exonuclease NEF-sp (208107_s_at), score: 0.57 LOH3CR2Aloss of heterozygosity, 3, chromosomal region 2, gene A (220244_at), score: -0.8 LPPR4plasticity related gene 1 (213496_at), score: -0.62 LRIG1leucine-rich repeats and immunoglobulin-like domains 1 (211596_s_at), score: -0.63 LSM2LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) (209449_at), score: 0.53 LSM5LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) (202904_s_at), score: 0.5 LSSlanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (211019_s_at), score: -0.91 LUZP1leucine zipper protein 1 (221832_s_at), score: -0.59 LYSTlysosomal trafficking regulator (203518_at), score: -0.6 LZTFL1leucine zipper transcription factor-like 1 (218437_s_at), score: -0.75 MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast) (203362_s_at), score: 0.77 MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) (36711_at), score: -0.56 MAMLD1mastermind-like domain containing 1 (205088_at), score: -0.68 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: -0.68 MAP3K8mitogen-activated protein kinase kinase kinase 8 (205027_s_at), score: -0.57 MC4Rmelanocortin 4 receptor (221467_at), score: 0.65 MCM10minichromosome maintenance complex component 10 (220651_s_at), score: 0.83 MCM2minichromosome maintenance complex component 2 (202107_s_at), score: 0.7 MCM3minichromosome maintenance complex component 3 (201555_at), score: 0.66 MCM4minichromosome maintenance complex component 4 (212141_at), score: 0.7 MCM5minichromosome maintenance complex component 5 (216237_s_at), score: 0.71 MCM7minichromosome maintenance complex component 7 (210983_s_at), score: 0.66 MDC1mediator of DNA damage checkpoint 1 (203062_s_at), score: 0.51 MDM1Mdm1 nuclear protein homolog (mouse) (213761_at), score: 0.67 MELKmaternal embryonic leucine zipper kinase (204825_at), score: 0.52 MFAP4microfibrillar-associated protein 4 (212713_at), score: -0.59 MGC87042similar to Six transmembrane epithelial antigen of prostate (217553_at), score: 0.52 MKI67antigen identified by monoclonal antibody Ki-67 (212022_s_at), score: 0.71 MLF1IPMLF1 interacting protein (218883_s_at), score: 0.64 MLXIPMLX interacting protein (202519_at), score: -0.55 MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase) (205828_at), score: 0.51 MPHOSPH9M-phase phosphoprotein 9 (206205_at), score: 0.54 MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae) (205395_s_at), score: 0.53 MSCmusculin (activated B-cell factor-1) (209928_s_at), score: -0.55 MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (209421_at), score: 0.64 MVDmevalonate (diphospho) decarboxylase (203027_s_at), score: -0.84 MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (202086_at), score: -0.67 MX2myxovirus (influenza virus) resistance 2 (mouse) (204994_at), score: -0.66 MXRA5matrix-remodelling associated 5 (209596_at), score: -0.58 MYBL1v-myb myeloblastosis viral oncogene homolog (avian)-like 1 (213906_at), score: 0.63 MYBL2v-myb myeloblastosis viral oncogene homolog (avian)-like 2 (201710_at), score: 0.52 MYCv-myc myelocytomatosis viral oncogene homolog (avian) (202431_s_at), score: -0.57 MYL5myosin, light chain 5, regulatory (205145_s_at), score: -0.6 MYO19myosin XIX (219320_at), score: 0.63 MYO1Emyosin IE (203072_at), score: -0.66 NAMPTnicotinamide phosphoribosyltransferase (217738_at), score: -0.61 NASPnuclear autoantigenic sperm protein (histone-binding) (201970_s_at), score: 0.62 NBEAneurobeachin (221207_s_at), score: -0.57 NCAPD2non-SMC condensin I complex, subunit D2 (201774_s_at), score: 0.62 NCAPD3non-SMC condensin II complex, subunit D3 (212789_at), score: 0.67 NCAPGnon-SMC condensin I complex, subunit G (218663_at), score: 0.7 NCAPG2non-SMC condensin II complex, subunit G2 (219588_s_at), score: 0.66 NCAPHnon-SMC condensin I complex, subunit H (212949_at), score: 0.71 NCOA1nuclear receptor coactivator 1 (209106_at), score: -0.64 NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae) (204162_at), score: 0.66 NDRG1N-myc downstream regulated 1 (200632_s_at), score: -0.67 NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like (212445_s_at), score: 0.57 NEDD9neural precursor cell expressed, developmentally down-regulated 9 (202149_at), score: -0.63 NEIL3nei endonuclease VIII-like 3 (E. coli) (219502_at), score: 0.69 NEK2NIMA (never in mitosis gene a)-related kinase 2 (204641_at), score: 0.68 NETO2neuropilin (NRP) and tolloid (TLL)-like 2 (218888_s_at), score: 0.54 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: -0.64 NFIL3nuclear factor, interleukin 3 regulated (203574_at), score: -0.57 NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: -0.55 NME5non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) (206197_at), score: -0.64 NPATnuclear protein, ataxia-telangiectasia locus (209798_at), score: 0.5 NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (201866_s_at), score: -0.62 NR4A1nuclear receptor subfamily 4, group A, member 1 (202340_x_at), score: -0.63 NR4A2nuclear receptor subfamily 4, group A, member 2 (216248_s_at), score: -0.61 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: -0.68 NSDHLNAD(P) dependent steroid dehydrogenase-like (215093_at), score: -0.58 NUP107nucleoporin 107kDa (218768_at), score: 0.54 NUP155nucleoporin 155kDa (206550_s_at), score: 0.57 NUP85nucleoporin 85kDa (218014_at), score: 0.51 NUP93nucleoporin 93kDa (202188_at), score: 0.49 NUPR1nuclear protein 1 (209230_s_at), score: -0.56 NUSAP1nucleolar and spindle associated protein 1 (218039_at), score: 0.65 OIP5Opa interacting protein 5 (213599_at), score: 0.73 OLFML1olfactomedin-like 1 (217525_at), score: -0.64 OLFML2Aolfactomedin-like 2A (213075_at), score: -0.74 OMDosteomodulin (205907_s_at), score: -0.67 OPLAH5-oxoprolinase (ATP-hydrolysing) (222025_s_at), score: -0.64 OPTNoptineurin (202073_at), score: -0.56 ORAI3ORAI calcium release-activated calcium modulator 3 (221864_at), score: -0.65 ORC1Lorigin recognition complex, subunit 1-like (yeast) (205085_at), score: 0.72 ORC6Lorigin recognition complex, subunit 6 like (yeast) (219105_x_at), score: 0.82 PANK3pantothenate kinase 3 (218433_at), score: -0.62 PANX1pannexin 1 (204715_at), score: -0.56 PAPPApregnancy-associated plasma protein A, pappalysin 1 (201981_at), score: -0.78 PARP12poly (ADP-ribose) polymerase family, member 12 (218543_s_at), score: -0.64 PARP2poly (ADP-ribose) polymerase 2 (214086_s_at), score: 0.65 PBKPDZ binding kinase (219148_at), score: 0.61 PCK2phosphoenolpyruvate carboxykinase 2 (mitochondrial) (202847_at), score: -0.56 PCNTpericentrin (203660_s_at), score: 0.53 PCSK7proprotein convertase subtilisin/kexin type 7 (203118_at), score: 0.51 PDE4Aphosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) (204735_at), score: -0.55 PDGFAplatelet-derived growth factor alpha polypeptide (205463_s_at), score: -0.66 PDGFDplatelet derived growth factor D (219304_s_at), score: -0.71 PDGFRBplatelet-derived growth factor receptor, beta polypeptide (202273_at), score: -0.78 PDGFRLplatelet-derived growth factor receptor-like (205226_at), score: -0.57 PDPNpodoplanin (221898_at), score: -0.64 PEG10paternally expressed 10 (212094_at), score: 0.5 PELI1pellino homolog 1 (Drosophila) (218319_at), score: -0.58 PGRMC2progesterone receptor membrane component 2 (213227_at), score: -0.58 PIGBphosphatidylinositol glycan anchor biosynthesis, class B (214151_s_at), score: -0.69 PIGZphosphatidylinositol glycan anchor biosynthesis, class Z (220041_at), score: -0.67 PIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide (203879_at), score: -0.56 PIP5K1Aphosphatidylinositol-4-phosphate 5-kinase, type I, alpha (207391_s_at), score: -0.61 PIRpirin (iron-binding nuclear protein) (207469_s_at), score: -0.67 PITPNC1phosphatidylinositol transfer protein, cytoplasmic 1 (219155_at), score: 0.51 PKIAprotein kinase (cAMP-dependent, catalytic) inhibitor alpha (204612_at), score: 0.57 PKMYT1protein kinase, membrane associated tyrosine/threonine 1 (204267_x_at), score: 0.68 PLA2G4Cphospholipase A2, group IVC (cytosolic, calcium-independent) (209785_s_at), score: -0.56 PLK1polo-like kinase 1 (Drosophila) (202240_at), score: 0.63 PLK4polo-like kinase 4 (Drosophila) (204887_s_at), score: 0.64 PLSCR4phospholipid scramblase 4 (218901_at), score: -0.7 PLXNC1plexin C1 (213241_at), score: -0.83 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: -0.63 POLA1polymerase (DNA directed), alpha 1, catalytic subunit (204835_at), score: 0.8 POLA2polymerase (DNA directed), alpha 2 (70kD subunit) (204441_s_at), score: 0.66 POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa (203422_at), score: 0.72 POLD3polymerase (DNA-directed), delta 3, accessory subunit (212836_at), score: 0.65 POLEpolymerase (DNA directed), epsilon (216026_s_at), score: 0.67 POLE2polymerase (DNA directed), epsilon 2 (p59 subunit) (205909_at), score: 0.78 POLQpolymerase (DNA directed), theta (219510_at), score: 0.72 POLR2Dpolymerase (RNA) II (DNA directed) polypeptide D (203664_s_at), score: 0.52 PPLperiplakin (203407_at), score: -0.95 PPP3CCprotein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (207000_s_at), score: -0.79 PRC1protein regulator of cytokinesis 1 (218009_s_at), score: 0.58 PRELPproline/arginine-rich end leucine-rich repeat protein (204223_at), score: -0.68 PRIM1primase, DNA, polypeptide 1 (49kDa) (205053_at), score: 0.81 PRKG1protein kinase, cGMP-dependent, type I (207119_at), score: -0.94 PRPS2phosphoribosyl pyrophosphate synthetase 2 (203401_at), score: 0.68 PRR11proline rich 11 (219392_x_at), score: 0.54 PRSS12protease, serine, 12 (neurotrypsin, motopsin) (205515_at), score: -0.69 PSMC3IPPSMC3 interacting protein (213951_s_at), score: 0.77 PSRC1proline/serine-rich coiled-coil 1 (201896_s_at), score: 0.64 PTGER4prostaglandin E receptor 4 (subtype EP4) (204897_at), score: -0.59 PTGESprostaglandin E synthase (210367_s_at), score: -0.58 PTHLHparathyroid hormone-like hormone (211756_at), score: -0.6 PTTG1pituitary tumor-transforming 1 (203554_x_at), score: 0.64 PTTG3pituitary tumor-transforming 3 (208511_at), score: 0.51 QPRTquinolinate phosphoribosyltransferase (204044_at), score: -0.83 RAB33ARAB33A, member RAS oncogene family (206039_at), score: -0.7 RACGAP1Rac GTPase activating protein 1 (222077_s_at), score: 0.58 RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) (205024_s_at), score: 0.57 RAD51AP1RAD51 associated protein 1 (204146_at), score: 0.66 RAD51L1RAD51-like 1 (S. cerevisiae) (210255_at), score: 0.5 RAD54BRAD54 homolog B (S. cerevisiae) (219494_at), score: 0.8 RAD54LRAD54-like (S. cerevisiae) (204558_at), score: 0.67 RAD9ARAD9 homolog A (S. pombe) (204828_at), score: 0.55 RANGAP1Ran GTPase activating protein 1 (212125_at), score: 0.66 RAPGEF2Rap guanine nucleotide exchange factor (GEF) 2 (203097_s_at), score: -0.56 RASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated) (205590_at), score: -0.86 RASGRP3RAS guanyl releasing protein 3 (calcium and DAG-regulated) (205801_s_at), score: 0.6 RASSF8Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 (207754_at), score: -0.6 RBL1retinoblastoma-like 1 (p107) (205296_at), score: 0.74 RCAN2regulator of calcineurin 2 (203498_at), score: -0.58 REEP4receptor accessory protein 4 (218777_at), score: 0.51 RELv-rel reticuloendotheliosis viral oncogene homolog (avian) (206036_s_at), score: -0.72 RELBv-rel reticuloendotheliosis viral oncogene homolog B (205205_at), score: -0.65 RFC2replication factor C (activator 1) 2, 40kDa (203696_s_at), score: 0.62 RFC3replication factor C (activator 1) 3, 38kDa (204127_at), score: 0.76 RFC4replication factor C (activator 1) 4, 37kDa (204023_at), score: 0.66 RFWD3ring finger and WD repeat domain 3 (218564_at), score: 0.61 RGS7regulator of G-protein signaling 7 (206290_s_at), score: 0.52 RHOQras homolog gene family, member Q (212119_at), score: -0.65 RICSRho GTPase-activating protein (203431_s_at), score: -0.59 RLFrearranged L-myc fusion (204243_at), score: -0.58 RMI1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) (218979_at), score: 0.54 RNASEH2Aribonuclease H2, subunit A (203022_at), score: 0.7 ROR1receptor tyrosine kinase-like orphan receptor 1 (205805_s_at), score: -0.66 RPA2replication protein A2, 32kDa (201756_at), score: 0.5 RPL39Lribosomal protein L39-like (210115_at), score: 0.58 RPP30ribonuclease P/MRP 30kDa subunit (203436_at), score: 0.52 RPRD2regulation of nuclear pre-mRNA domain containing 2 (212553_at), score: 0.54 RRAGBRas-related GTP binding B (205540_s_at), score: -0.74 RRM1ribonucleotide reductase M1 (201476_s_at), score: 0.55 RRM2ribonucleotide reductase M2 polypeptide (209773_s_at), score: 0.53 RSL24D1ribosomal L24 domain containing 1 (217915_s_at), score: -0.57 RTN2reticulon 2 (34408_at), score: -0.56 RUNX1runt-related transcription factor 1 (209360_s_at), score: -0.69 SAMD4Asterile alpha motif domain containing 4A (212845_at), score: -0.57 SAP30Sin3A-associated protein, 30kDa (204900_x_at), score: 0.51 SC4MOLsterol-C4-methyl oxidase-like (209146_at), score: -0.95 SC5DLsterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like (211423_s_at), score: -0.59 SCARA3scavenger receptor class A, member 3 (219416_at), score: 0.55 SCDstearoyl-CoA desaturase (delta-9-desaturase) (200832_s_at), score: -0.86 SEMA3Dsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D (215324_at), score: -0.71 SGK1serum/glucocorticoid regulated kinase 1 (201739_at), score: -0.69 SH3TC2SH3 domain and tetratricopeptide repeats 2 (219710_at), score: 0.52 SHCBP1SHC SH2-domain binding protein 1 (219493_at), score: 0.63 SHMT1serine hydroxymethyltransferase 1 (soluble) (209980_s_at), score: 0.58 SKILSKI-like oncogene (206675_s_at), score: -0.69 SKIV2Lsuperkiller viralicidic activity 2-like (S. cerevisiae) (203727_at), score: 0.49 SLC19A1solute carrier family 19 (folate transporter), member 1 (211576_s_at), score: 0.64 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: -0.66 SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3 (202800_at), score: -0.68 SLC29A1solute carrier family 29 (nucleoside transporters), member 1 (201801_s_at), score: 0.5 SLC2A14solute carrier family 2 (facilitated glucose transporter), member 14 (222088_s_at), score: -0.86 SLC2A3solute carrier family 2 (facilitated glucose transporter), member 3 (202499_s_at), score: -0.69 SLC2A3P1solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 1 (221751_at), score: -0.8 SLC46A3solute carrier family 46, member 3 (214719_at), score: -0.67 SMC2structural maintenance of chromosomes 2 (204240_s_at), score: 0.71 SMC4structural maintenance of chromosomes 4 (201663_s_at), score: 0.54 SMOXspermine oxidase (210357_s_at), score: -0.71 SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) (214708_at), score: -0.68 SOX9SRY (sex determining region Y)-box 9 (202935_s_at), score: -0.59 SPAG5sperm associated antigen 5 (203145_at), score: 0.73 SPATA2Lspermatogenesis associated 2-like (214965_at), score: -0.69 SPC25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) (209891_at), score: 0.71 SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: -0.56 SPSB1splA/ryanodine receptor domain and SOCS box containing 1 (219677_at), score: -0.63 SQLEsqualene epoxidase (213562_s_at), score: -0.98 SREBF1sterol regulatory element binding transcription factor 1 (202308_at), score: -0.66 SREBF2sterol regulatory element binding transcription factor 2 (201247_at), score: -0.83 SRFserum response factor (c-fos serum response element-binding transcription factor) (202401_s_at), score: -0.63 SSX2IPsynovial sarcoma, X breakpoint 2 interacting protein (203016_s_at), score: 0.63 ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (208322_s_at), score: -0.6 STACSH3 and cysteine rich domain (205743_at), score: -0.59 STILSCL/TAL1 interrupting locus (205339_at), score: 0.73 STK38Lserine/threonine kinase 38 like (212572_at), score: -0.86 STMN1stathmin 1/oncoprotein 18 (200783_s_at), score: 0.61 STX6syntaxin 6 (212799_at), score: -0.55 SUPT16Hsuppressor of Ty 16 homolog (S. cerevisiae) (217815_at), score: 0.52 SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila) (218619_s_at), score: 0.63 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: -0.74 SYNPOsynaptopodin (202796_at), score: -0.57 TACC3transforming, acidic coiled-coil containing protein 3 (218308_at), score: 0.71 TACSTD2tumor-associated calcium signal transducer 2 (202286_s_at), score: -0.89 TBC1D12TBC1 domain family, member 12 (221858_at), score: -0.73 TCEA2transcription elongation factor A (SII), 2 (203919_at), score: -0.61 TDP1tyrosyl-DNA phosphodiesterase 1 (219715_s_at), score: 0.51 TELO2TEL2, telomere maintenance 2, homolog (S. cerevisiae) (34260_at), score: 0.51 TFDP1transcription factor Dp-1 (212330_at), score: 0.49 TGFBR1transforming growth factor, beta receptor 1 (206943_at), score: -0.8 THAP10THAP domain containing 10 (219596_at), score: 0.55 TICAM1toll-like receptor adaptor molecule 1 (213191_at), score: -0.55 TIMELESStimeless homolog (Drosophila) (203046_s_at), score: 0.73 TIPINTIMELESS interacting protein (219258_at), score: 0.54 TK1thymidine kinase 1, soluble (202338_at), score: 0.57 TM6SF1transmembrane 6 superfamily member 1 (219892_at), score: -0.69 TM7SF2transmembrane 7 superfamily member 2 (210130_s_at), score: -0.83 TMEM106Ctransmembrane protein 106C (201764_at), score: 0.49 TMEM194Atransmembrane protein 194A (212621_at), score: 0.81 TMEM48transmembrane protein 48 (218073_s_at), score: 0.65 TMPOthymopoietin (209754_s_at), score: 0.52 TNFAIP6tumor necrosis factor, alpha-induced protein 6 (206026_s_at), score: -0.69 TNFAIP8tumor necrosis factor, alpha-induced protein 8 (210260_s_at), score: -0.61 TNFRSF10Btumor necrosis factor receptor superfamily, member 10b (209295_at), score: -0.63 TNFRSF21tumor necrosis factor receptor superfamily, member 21 (214581_x_at), score: 0.5 TNFSF9tumor necrosis factor (ligand) superfamily, member 9 (206907_at), score: -0.63 TNS3tensin 3 (217853_at), score: -0.55 TNXAtenascin XA pseudogene (213451_x_at), score: -0.7 TNXBtenascin XB (216333_x_at), score: -0.67 TOP2Atopoisomerase (DNA) II alpha 170kDa (201291_s_at), score: 0.52 TOPBP1topoisomerase (DNA) II binding protein 1 (202633_at), score: 0.5 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: -0.69 TPD52L1tumor protein D52-like 1 (203786_s_at), score: -0.62 TPX2TPX2, microtubule-associated, homolog (Xenopus laevis) (210052_s_at), score: 0.7 TRAPPC6Atrafficking protein particle complex 6A (204985_s_at), score: -0.61 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: -0.59 TRIP13thyroid hormone receptor interactor 13 (204033_at), score: 0.69 TRMT5TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae) (221952_x_at), score: 0.52 TROAPtrophinin associated protein (tastin) (204649_at), score: 0.53 TRPC6transient receptor potential cation channel, subfamily C, member 6 (217287_s_at), score: -0.73 TRPS1trichorhinophalangeal syndrome I (218502_s_at), score: -0.65 TSC22D3TSC22 domain family, member 3 (208763_s_at), score: -0.76 TTC17tetratricopeptide repeat domain 17 (218972_at), score: -0.74 TTF2transcription termination factor, RNA polymerase II (204407_at), score: 0.52 TTKTTK protein kinase (204822_at), score: 0.8 TUBGCP5tubulin, gamma complex associated protein 5 (214876_s_at), score: 0.51 TUFT1tuftelin 1 (205807_s_at), score: -0.62 TXNIPthioredoxin interacting protein (201008_s_at), score: 0.62 UBA7ubiquitin-like modifier activating enzyme 7 (203281_s_at), score: -0.55 UBE2Cubiquitin-conjugating enzyme E2C (202954_at), score: 0.61 UBR7ubiquitin protein ligase E3 component n-recognin 7 (putative) (218108_at), score: 0.54 UNGuracil-DNA glycosylase (202330_s_at), score: 0.58 USPL1ubiquitin specific peptidase like 1 (204190_at), score: -0.58 USTuronyl-2-sulfotransferase (205139_s_at), score: -0.66 VCLvinculin (200930_s_at), score: -0.73 VDRvitamin D (1,25- dihydroxyvitamin D3) receptor (204255_s_at), score: -0.56 VEGFAvascular endothelial growth factor A (211527_x_at), score: -0.65 VRK1vaccinia related kinase 1 (203856_at), score: 0.62 WDHD1WD repeat and HMG-box DNA binding protein 1 (216228_s_at), score: 0.7 WDR62WD repeat domain 62 (215218_s_at), score: 0.53 WDR76WD repeat domain 76 (205519_at), score: 0.67 WEE1WEE1 homolog (S. pombe) (212533_at), score: 0.56 WHSC1Wolf-Hirschhorn syndrome candidate 1 (209053_s_at), score: 0.65 WISP1WNT1 inducible signaling pathway protein 1 (206796_at), score: -0.63 WNT2wingless-type MMTV integration site family member 2 (205648_at), score: -0.76 WRAP53WD repeat containing, antisense to TP53 (44563_at), score: 0.65 XAF1XIAP associated factor 1 (206133_at), score: -0.59 YOD1YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) (215150_at), score: -0.68 YPEL5yippee-like 5 (Drosophila) (217783_s_at), score: -0.72 ZCCHC6zinc finger, CCHC domain containing 6 (220933_s_at), score: -0.63 ZNF394zinc finger protein 394 (214714_at), score: -0.61 ZNF85zinc finger protein 85 (206572_x_at), score: 0.62 ZWILCHZwilch, kinetochore associated, homolog (Drosophila) (218349_s_at), score: 0.55 ZWINTZW10 interactor (204026_s_at), score: 0.61

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
E-TABM-263-raw-cel-1515486231.cel	30	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515485851.cel	11	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486331.cel	35	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486271.cel	32	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486291.cel	33	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486351.cel	36	6	Cycle	hgu133a2	none	Cycle 1