Under-expression is coded with green,
over-expression with red color.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
carbohydrate metabolic process
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
monosaccharide metabolic process
The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.
glucose metabolic process
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
alcohol metabolic process
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
organic acid metabolic process
The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
pyruvate metabolic process
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
gluconeogenesis
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
oxidation reduction
The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
L-phenylalanine metabolic process
The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid.
L-phenylalanine catabolic process
The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.
tyrosine metabolic process
The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.
tyrosine catabolic process
The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.
cellular amino acid derivative metabolic process
The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
cellular biogenic amine metabolic process
The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
cellular aromatic compound metabolic process
The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
cellular amino acid biosynthetic process
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
biosynthetic process
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
cellular amino acid catabolic process
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
aromatic amino acid family metabolic process
The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
aromatic amino acid family catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
amine biosynthetic process
The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
amine catabolic process
The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
response to toxin
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxin stimulus.
response to carbohydrate stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.
response to hexose stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
response to organic substance
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
carbohydrate biosynthetic process
The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
organic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
hexose metabolic process
The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.
hexose biosynthetic process
The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.
aromatic compound catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
beta-alanine metabolic process
The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
carboxylic acid metabolic process
The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
monocarboxylic acid metabolic process
The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).
response to monosaccharide stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus.
cellular carbohydrate biosynthetic process
The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
cellular ketone metabolic process
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
response to chemical stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
cellular amino acid derivative biosynthetic process
The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents.
cellular biogenic amine biosynthetic process
The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
oxoacid metabolic process
The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
cellular amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular carbohydrate metabolic process
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.
cellular nitrogen compound biosynthetic process
The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.
small molecule metabolic process
The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
small molecule biosynthetic process
The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.
alcohol biosynthetic process
The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
monosaccharide biosynthetic process
The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms.
carboxylic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
carboxylic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
response to stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
all
NA
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
organic acid metabolic process
The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
cellular ketone metabolic process
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
small molecule biosynthetic process
The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.
cellular amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
cellular carbohydrate biosynthetic process
The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells.
cellular nitrogen compound biosynthetic process
The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.
organic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
cellular amino acid derivative biosynthetic process
The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents.
organic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
aromatic compound catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
oxoacid metabolic process
The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
cellular carbohydrate biosynthetic process
The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells.
carbohydrate biosynthetic process
The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
cellular carbohydrate metabolic process
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.
monosaccharide metabolic process
The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.
alcohol biosynthetic process
The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
amine biosynthetic process
The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
cellular biogenic amine biosynthetic process
The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
monosaccharide biosynthetic process
The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms.
cellular amino acid biosynthetic process
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
cellular amino acid catabolic process
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
aromatic amino acid family metabolic process
The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
cellular biogenic amine metabolic process
The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
cellular amino acid derivative biosynthetic process
The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents.
aromatic amino acid family catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
monosaccharide biosynthetic process
The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms.
aromatic amino acid family catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
cellular biogenic amine biosynthetic process
The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
cellular amino acid catabolic process
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
cellular amino acid biosynthetic process
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
carboxylic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
carboxylic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
L-phenylalanine catabolic process
The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.
tyrosine catabolic process
The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.
hexose biosynthetic process
The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.
gluconeogenesis
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
gluconeogenesis
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
cell fraction
A generic term for parts of cells prepared by disruptive biochemical techniques.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
membrane fraction
That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes.
insoluble fraction
That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water.
cytoplasm
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cell-cell junction
A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals.
cell junction
A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
intrinsic to membrane
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
apical part of cell
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
intercellular canaliculus
An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates.
all
NA
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
catalytic activity
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
aminopeptidase activity
Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.
peptidase activity
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
phosphoenolpyruvate carboxykinase activity
Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2.
phosphoenolpyruvate carboxykinase (GTP) activity
Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.
transporter activity
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
transmembrane transporter activity
Enables the transfer of a substance from one side of a membrane to the other.
binding
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
oxidoreductase activity
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
methyltransferase activity
Catalysis of the transfer of a methyl group to an acceptor molecule.
S-methyltransferase activity
Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule.
exopeptidase activity
Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.
acyltransferase activity
Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier.
anion transmembrane transporter activity
Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other.
S-adenosylmethionine-dependent methyltransferase activity
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
homocysteine S-methyltransferase activity
Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine.
peptidase activity, acting on L-amino acid peptides
Catalysis of the hydrolysis of peptide bonds formed between L-amino acids.
ion transmembrane transporter activity
Catalysis of the transfer of an ion from one side of a membrane to the other.
inorganic anion transmembrane transporter activity
Catalysis of the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.
phosphate transmembrane transporter activity
Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other.
vitamin transporter activity
Enables the directed movement of vitamins into, out of, within or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
N-acyltransferase activity
Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.
oxidoreductase activity, acting on CH-OH group of donors
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
transferase activity
Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
transferase activity, transferring one-carbon groups
Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor).
transferase activity, transferring acyl groups
Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
transferase activity, transferring acyl groups other than amino-acyl groups
Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
hydrolase activity
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
lyase activity
Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
carbon-carbon lyase activity
Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
carboxy-lyase activity
Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
substrate-specific transporter activity
Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
carboxylic acid binding
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
dehydroascorbic acid transporter activity
Enables the directed movement of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, into, out of, within or between cells by means of some external agent such as a transporter or pore.
betaine-homocysteine S-methyltransferase activity
Catalysis of the reaction: homocysteine + betaine = L-methionine + dimethylglycine.
glycine N-acyltransferase activity
Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine.
cofactor binding
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
coenzyme binding
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
all
NA
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
homocysteine S-methyltransferase activity
Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine.
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 01100 | 9.031e-10 | 12.59 | 37 | 805 | Metabolic pathways |
| 00010 | 1.102e-05 | 0.6569 | 8 | 42 | Glycolysis / Gluconeogenesis |
| 00260 | 9.691e-04 | 0.3754 | 5 | 24 | Glycine, serine and threonine metabolism |
| 04950 | 2.104e-03 | 0.2346 | 4 | 15 | Maturity onset diabetes of the young |
| 00350 | 3.436e-03 | 0.5005 | 5 | 32 | Tyrosine metabolism |
| 04964 | 4.069e-03 | 0.2815 | 4 | 18 | Proximal tubule bicarbonate reclamation |
| 03320 | 1.990e-02 | 0.7821 | 5 | 50 | PPAR signaling pathway |
| 00380 | 2.707e-02 | 0.5005 | 4 | 32 | Tryptophan metabolism |
| 00360 | 2.767e-02 | 0.2346 | 3 | 15 | Phenylalanine metabolism |
| 00410 | 3.199e-02 | 0.2503 | 3 | 16 | beta-Alanine metabolism |
| 04614 | 3.199e-02 | 0.2503 | 3 | 16 | Renin-angiotensin system |
A1CFAPOBEC1 complementation factor (ENSG00000148584), score: 0.92 ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ENSG00000023839), score: 0.93 ABHD14Babhydrolase domain containing 14B (ENSG00000114779), score: 0.91 ACAA1acetyl-CoA acyltransferase 1 (ENSG00000060971), score: 0.93 ACMSDaminocarboxymuconate semialdehyde decarboxylase (ENSG00000153086), score: 0.99 ACSM3acyl-CoA synthetase medium-chain family member 3 (ENSG00000005187), score: 0.88 ACY1aminoacylase 1 (ENSG00000243989), score: 0.91 ADH6alcohol dehydrogenase 6 (class V) (ENSG00000172955), score: 0.9 AFMafamin (ENSG00000079557), score: 0.88 AGMATagmatine ureohydrolase (agmatinase) (ENSG00000116771), score: 0.96 AGPHD1aminoglycoside phosphotransferase domain containing 1 (ENSG00000188266), score: 0.88 AGXT2alanine--glyoxylate aminotransferase 2 (ENSG00000113492), score: 0.97 AKR1A1aldo-keto reductase family 1, member A1 (aldehyde reductase) (ENSG00000117448), score: 0.92 ALDH6A1aldehyde dehydrogenase 6 family, member A1 (ENSG00000119711), score: 0.88 ALDH8A1aldehyde dehydrogenase 8 family, member A1 (ENSG00000118514), score: 0.94 ALDOBaldolase B, fructose-bisphosphate (ENSG00000136872), score: 0.98 ANKS4Bankyrin repeat and sterile alpha motif domain containing 4B (ENSG00000175311), score: 0.99 ANPEPalanyl (membrane) aminopeptidase (ENSG00000166825), score: 0.97 APOMapolipoprotein M (ENSG00000204444), score: 0.91 ATP1A3ATPase, Na+/K+ transporting, alpha 3 polypeptide (ENSG00000105409), score: -0.92 BBOX1butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 (ENSG00000129151), score: 0.89 BHMTbetaine--homocysteine S-methyltransferase (ENSG00000145692), score: 0.98 BHMT2betaine--homocysteine S-methyltransferase 2 (ENSG00000132840), score: 0.94 BPHLbiphenyl hydrolase-like (serine hydrolase) (ENSG00000137274), score: 0.88 BTDbiotinidase (ENSG00000169814), score: 0.9 C11orf52chromosome 11 open reading frame 52 (ENSG00000149300), score: 0.9 C11orf54chromosome 11 open reading frame 54 (ENSG00000182919), score: 0.91 C14orf73chromosome 14 open reading frame 73 (ENSG00000205436), score: 0.92 C4orf19chromosome 4 open reading frame 19 (ENSG00000154274), score: 0.87 CBLCCas-Br-M (murine) ecotropic retroviral transforming sequence c (ENSG00000142273), score: 0.9 CDH1cadherin 1, type 1, E-cadherin (epithelial) (ENSG00000039068), score: 0.96 CDHR5cadherin-related family member 5 (ENSG00000099834), score: 0.93 CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (ENSG00000079385), score: 0.88 CLCN5chloride channel 5 (ENSG00000171365), score: 0.9 CMBLcarboxymethylenebutenolidase homolog (Pseudomonas) (ENSG00000164237), score: 0.92 CRB3crumbs homolog 3 (Drosophila) (ENSG00000130545), score: 0.93 CRYL1crystallin, lambda 1 (ENSG00000165475), score: 0.9 CTAGE5CTAGE family, member 5 (ENSG00000150527), score: 0.89 CYB5Acytochrome b5 type A (microsomal) (ENSG00000166347), score: 0.92 DDCdopa decarboxylase (aromatic L-amino acid decarboxylase) (ENSG00000132437), score: 0.96 DEFB1defensin, beta 1 (ENSG00000164825), score: 0.9 DHDPSLdihydrodipicolinate synthase-like, mitochondrial (ENSG00000241935), score: 0.92 DIO1deiodinase, iodothyronine, type I (ENSG00000211452), score: 1 DMGDHdimethylglycine dehydrogenase (ENSG00000132837), score: 0.96 DNAJC22DnaJ (Hsp40) homolog, subfamily C, member 22 (ENSG00000178401), score: 0.91 DPP4dipeptidyl-peptidase 4 (ENSG00000197635), score: 0.88 DPYSdihydropyrimidinase (ENSG00000147647), score: 0.97 EHHADHenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (ENSG00000113790), score: 0.94 ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific ) (ENSG00000163435), score: 0.88 ENPEPglutamyl aminopeptidase (aminopeptidase A) (ENSG00000138792), score: 0.93 EPHX2epoxide hydrolase 2, cytoplasmic (ENSG00000120915), score: 0.9 FAHfumarylacetoacetate hydrolase (fumarylacetoacetase) (ENSG00000103876), score: 0.9 FAM176Afamily with sequence similarity 176, member A (ENSG00000115363), score: 0.89 FBP1fructose-1,6-bisphosphatase 1 (ENSG00000165140), score: 0.97 FGFR4fibroblast growth factor receptor 4 (ENSG00000160867), score: 0.93 FMO4flavin containing monooxygenase 4 (ENSG00000076258), score: 0.92 GALMgalactose mutarotase (aldose 1-epimerase) (ENSG00000143891), score: 0.93 GCHFRGTP cyclohydrolase I feedback regulator (ENSG00000137880), score: 0.88 GLYATglycine-N-acyltransferase (ENSG00000149124), score: 0.98 GLYATL1glycine-N-acyltransferase-like 1 (ENSG00000166840), score: 0.99 GLYCTKglycerate kinase (ENSG00000168237), score: 0.93 HAO2hydroxyacid oxidase 2 (long chain) (ENSG00000116882), score: 1 HGDhomogentisate 1,2-dioxygenase (ENSG00000113924), score: 0.98 HNF1AHNF1 homeobox A (ENSG00000135100), score: 0.91 HNF4Ahepatocyte nuclear factor 4, alpha (ENSG00000101076), score: 0.98 HPD4-hydroxyphenylpyruvate dioxygenase (ENSG00000158104), score: 0.94 HPGDhydroxyprostaglandin dehydrogenase 15-(NAD) (ENSG00000164120), score: 0.89 HPNhepsin (ENSG00000105707), score: 0.94 IYDiodotyrosine deiodinase (ENSG00000009765), score: 0.96 KCNK5potassium channel, subfamily K, member 5 (ENSG00000164626), score: 0.92 KHKketohexokinase (fructokinase) (ENSG00000138030), score: 0.89 KIF12kinesin family member 12 (ENSG00000136883), score: 0.88 KLHDC7Akelch domain containing 7A (ENSG00000179023), score: 0.9 KMOkynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (ENSG00000117009), score: 0.91 KNG1kininogen 1 (ENSG00000113889), score: 0.97 LAD1ladinin 1 (ENSG00000159166), score: 0.93 MARVELD2MARVEL domain containing 2 (ENSG00000152939), score: 0.89 MARVELD3MARVEL domain containing 3 (ENSG00000140832), score: 0.88 MMEmembrane metallo-endopeptidase (ENSG00000196549), score: 0.91 NAGSN-acetylglutamate synthase (ENSG00000161653), score: 0.88 NDRG4NDRG family member 4 (ENSG00000103034), score: -0.9 NR1H4nuclear receptor subfamily 1, group H, member 4 (ENSG00000012504), score: 0.93 PAHphenylalanine hydroxylase (ENSG00000171759), score: 0.96 PBLDphenazine biosynthesis-like protein domain containing (ENSG00000108187), score: 0.91 PCK1phosphoenolpyruvate carboxykinase 1 (soluble) (ENSG00000124253), score: 0.93 PCK2phosphoenolpyruvate carboxykinase 2 (mitochondrial) (ENSG00000100889), score: 0.91 PEPDpeptidase D (ENSG00000124299), score: 0.88 PIGRpolymeric immunoglobulin receptor (ENSG00000162896), score: 0.95 PKLRpyruvate kinase, liver and RBC (ENSG00000143627), score: 0.92 PLA2G12Bphospholipase A2, group XIIB (ENSG00000138308), score: 0.89 PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific) (ENSG00000197943), score: 0.88 PRAP1proline-rich acidic protein 1 (ENSG00000165828), score: 0.87 RAB17RAB17, member RAS oncogene family (ENSG00000124839), score: 0.95 RBP5retinol binding protein 5, cellular (ENSG00000139194), score: 0.95 RIPK4receptor-interacting serine-threonine kinase 4 (ENSG00000183421), score: 0.92 SARDHsarcosine dehydrogenase (ENSG00000123453), score: 0.92 SDC1syndecan 1 (ENSG00000115884), score: 0.96 SERPINA1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (ENSG00000197249), score: 0.87 SERPINA6serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (ENSG00000170099), score: 0.92 SERPINF2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 (ENSG00000167711), score: 0.89 SH2D4ASH2 domain containing 4A (ENSG00000104611), score: 0.91 SLC17A1solute carrier family 17 (sodium phosphate), member 1 (ENSG00000124568), score: 0.97 SLC17A3solute carrier family 17 (sodium phosphate), member 3 (ENSG00000124564), score: 0.95 SLC17A4solute carrier family 17 (sodium phosphate), member 4 (ENSG00000146039), score: 0.87 SLC22A7solute carrier family 22 (organic anion transporter), member 7 (ENSG00000137204), score: 0.94 SLC23A1solute carrier family 23 (nucleobase transporters), member 1 (ENSG00000170482), score: 0.99 SLC25A10solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 (ENSG00000183048), score: 0.88 SLC27A2solute carrier family 27 (fatty acid transporter), member 2 (ENSG00000140284), score: 0.96 SLC2A2solute carrier family 2 (facilitated glucose transporter), member 2 (ENSG00000163581), score: 0.88 SLC37A4solute carrier family 37 (glucose-6-phosphate transporter), member 4 (ENSG00000137700), score: 0.95 SLC5A9solute carrier family 5 (sodium/glucose cotransporter), member 9 (ENSG00000117834), score: 0.93 SLC7A9solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 (ENSG00000021488), score: 0.89 SUMF1sulfatase modifying factor 1 (ENSG00000144455), score: 0.88 TM6SF2transmembrane 6 superfamily member 2 (ENSG00000213996), score: 0.95 TMBIM6transmembrane BAX inhibitor motif containing 6 (ENSG00000139644), score: 0.93 TMEM27transmembrane protein 27 (ENSG00000147003), score: 0.89 TMEM37transmembrane protein 37 (ENSG00000171227), score: 0.92 TMEM82transmembrane protein 82 (ENSG00000162460), score: 0.97 TMPRSS2transmembrane protease, serine 2 (ENSG00000184012), score: 0.91 UGT2B7UDP glucuronosyltransferase 2 family, polypeptide B7 (ENSG00000171234), score: 0.94 UGT3A1UDP glycosyltransferase 3 family, polypeptide A1 (ENSG00000145626), score: 0.88 UPB1ureidopropionase, beta (ENSG00000100024), score: 0.93 VIL1villin 1 (ENSG00000127831), score: 0.89 WDR72WD repeat domain 72 (ENSG00000166415), score: 0.89
| Id | species | tissue | sex | individual |
|---|---|---|---|---|
| ppa_kd_m_ca1 | ppa | kd | m | _ |
| ptr_kd_f_ca1 | ptr | kd | f | _ |
| ppy_lv_f_ca1 | ppy | lv | f | _ |
| ppy_kd_f_ca1 | ppy | kd | f | _ |
| ppa_kd_f_ca1 | ppa | kd | f | _ |
| ggo_lv_m_ca1 | ggo | lv | m | _ |
| ggo_kd_f_ca1 | ggo | kd | f | _ |
| ppy_kd_m_ca1 | ppy | kd | m | _ |
| mml_kd_f_ca1 | mml | kd | f | _ |
| ggo_lv_f_ca1 | ggo | lv | f | _ |
| mml_kd_m_ca1 | mml | kd | m | _ |
| ptr_kd_m_ca1 | ptr | kd | m | _ |
| ppa_lv_m_ca1 | ppa | lv | m | _ |
| ppy_lv_m_ca1 | ppy | lv | m | _ |
| ggo_kd_m_ca1 | ggo | kd | m | _ |
| hsa_kd_f_ca1 | hsa | kd | f | _ |
| hsa_kd_m2_ca1 | hsa | kd | m | 2 |
| hsa_kd_m1_ca1 | hsa | kd | m | 1 |
| mml_lv_f_ca1 | mml | lv | f | _ |
| ppa_lv_f_ca1 | ppa | lv | f | _ |
| ptr_lv_m_ca1 | ptr | lv | m | _ |
| hsa_lv_m2_ca1 | hsa | lv | m | 2 |
| hsa_lv_m1_ca1 | hsa | lv | m | 1 |
| mml_lv_m_ca1 | mml | lv | m | _ |
