Module #51, TG: 2.6, TC: 2.6, 175 probes, 175 Entrez genes, 3 conditions

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Under-expression is coded with green, over-expression with red color.

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This is one of three sections showing Gene Ontology enrichment of the current module: in this case for biological processes.

The graph shows the hierarchy of the GO categories, their enrichment for the current module is color coded, and the blue number beside the category is the minus log ten p-value of the enrichment. (Calculated using the standard hypergeometric test.) The color of the arrows code «is a» (cyan) and «part of» relationships.

The tree was built the following way. First all GO terms with more significant enrichment p-value than 0.05 were collected. Then all paths from these terms to the root node of the GO tree were included too. If a GO term is included more than once in the tree, then the green numbers show 1) the id of the node, this makes it easier to find other appereances of the term, and 2) the number of appearences.

Note that the same GO category might show up on the graph many times. This is because the GO was «straightened» for this graph, i.e. if there are more paths from a GO term to the root node of the tree, all of them are included. The green numbers

Move the mouse cursor over the terms to get their definition. Clicking on them takes you to the corresponding Gene Ontology web page.

If you cannot see a graph here at all, that means that there were no significantly enriched GO categories, at the 0.05 level.

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blood vessel development

The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

vasculature development

The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure.

heart looping

The characteristic morphogenetic movements where the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration.

morphogenesis of an epithelium

The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.

heart morphogenesis

The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

skeletal muscle contraction

A process whereby force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.

voluntary skeletal muscle contraction

A process whereby force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control.

muscle system process

A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.

circulatory system process

A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.

heart process

A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

embryonic heart tube morphogenesis

The process by which the anatomical structures of the embryonic heart tube are generated and organized. Morphogenesis pertains to the creation of form. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.

cardiac conduction system development

The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.

His-Purkinje system development

The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.

bundle of His development

The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.

cardiac chamber development

The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.

cardiac chamber morphogenesis

The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.

cardiac chamber formation

The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.

cardiac ventricle morphogenesis

The process by which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

cardiac ventricle formation

The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

cardiac left ventricle morphogenesis

The process by which the left cardiac ventricle is generated and organized.

cardiac left ventricle formation

The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts.

ventricular cardiac muscle tissue development

The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.

cardiac ventricle development

The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

muscle contraction

A process whereby force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.

actin cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

regulation of muscle contraction

Any process that modulates the frequency, rate or extent of muscle contraction.

striated muscle contraction

A process whereby force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.

regulation of striated muscle contraction

Any process that modulates the frequency, rate or extent of striated muscle contraction.

organelle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

embryo development

The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

heart development

The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

adult heart development

The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure.

muscle organ development

The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.

blood circulation

The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.

regulation of heart contraction

Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

actin filament-based movement

Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cellular component assembly

The aggregation, arrangement and bonding together of a cellular component.

anatomical structure formation involved in morphogenesis

The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular component assembly involved in morphogenesis

The cellular component assembly that is part of the initial shaping of the component during its developmental progression.

striated muscle tissue development

The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.

twitch skeletal muscle contraction

A process whereby force is generated within twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The twitch skeletal muscle responds to neurostimulations with a contraction followed by a relaxation.

gas transport

The directed movement of substances that are gaseous in normal living conditions into, out of, within or between cells by means of some external agent such as a transporter or pore.

cellular component organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.

actin filament-based process

Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.

muscle filament sliding

The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

myofibril assembly

Formation of myofibrils, the repeating units of striated muscle.

cytoskeleton-dependent intracellular transport

The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.

actomyosin structure organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.

slow-twitch skeletal muscle fiber contraction

A process whereby force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

cellular component morphogenesis

The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.

actin-myosin filament sliding

The sliding movement of actin thin filaments and myosin thick filaments past each other.

embryonic heart tube development

The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.

cardiac cell differentiation

The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.

tube morphogenesis

The process by which the anatomical structures of a tube are generated and organized. Morphogenesis pertains to the creation of form. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.

tube development

The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.

muscle cell differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

cellular component biogenesis

The process by which a cellular component is synthesized, aggregates, and bonds together. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.

intracellular transport

The directed movement of substances within a cell.

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

embryonic morphogenesis

The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.

tissue morphogenesis

The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

cardiac muscle tissue development

The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

multicellular organismal movement

Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism.

musculoskeletal movement

The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.

striated muscle cell differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

muscle cell development

The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.

striated muscle cell development

The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.

cardiac cell development

The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual.

cardiac muscle cell differentiation

The process whereby a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.

cardiac muscle tissue morphogenesis

The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.

ventricular cardiac muscle tissue morphogenesis

The process by which the anatomical structures of cardiac ventricle muscle is generated and organized. Morphogenesis pertains to the creation of form.

cardiac muscle cell development

The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.

heart contraction

The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.

cardiac muscle contraction

Muscle contraction of cardiac muscle tissue.

muscle tissue morphogenesis

The process by which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. Morphogenesis pertains to the creation of form.

epithelium development

The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.

muscle tissue development

The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.

epithelial tube morphogenesis

The process by which the anatomical structures of a tube are generated and organized from an epithelium. Morphogenesis pertains to the creation of form. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.

muscle structure development

The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

actin-mediated cell contraction

The actin filament-based process by which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.

regulation of muscle system process

Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.

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organelle organization

multicellular organismal development

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

cellular component assembly

The aggregation, arrangement and bonding together of a cellular component.

regulation of multicellular organismal process

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

regulation of biological process

cellular component morphogenesis

The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

cellular component assembly involved in morphogenesis

The cellular component assembly that is part of the initial shaping of the component during its developmental progression.

embryo development

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

anatomical structure formation involved in morphogenesis

cellular component morphogenesis

The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.

embryonic morphogenesis

cellular component assembly involved in morphogenesis

The cellular component assembly that is part of the initial shaping of the component during its developmental progression.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

tube development

cell development

system development

intracellular transport

The directed movement of substances within a cell.

actin cytoskeleton organization

actin-myosin filament sliding

The sliding movement of actin thin filaments and myosin thick filaments past each other.

cell development

regulation of muscle system process

Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.

embryonic heart tube development

tube morphogenesis

organ development

cardiac chamber formation

The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.

tissue morphogenesis

The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.

embryonic heart tube morphogenesis

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

His-Purkinje system development

bundle of His development

cardiac chamber morphogenesis

The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.

tissue morphogenesis

The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.

organ morphogenesis

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

muscle organ development

muscle cell differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell.

myofibril assembly

Formation of myofibrils, the repeating units of striated muscle.

cardiac cell development

muscle cell development

cardiac muscle cell development

The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.

muscle filament sliding

regulation of muscle contraction

Any process that modulates the frequency, rate or extent of muscle contraction.

heart contraction

The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.

cardiac ventricle formation

The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

embryonic heart tube morphogenesis

cardiac chamber morphogenesis

The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.

embryonic heart tube morphogenesis

heart looping

The characteristic morphogenetic movements where the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration.

epithelial tube morphogenesis

cardiac muscle tissue morphogenesis

The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.

cardiac ventricle morphogenesis

The process by which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

morphogenesis of an epithelium

blood vessel development

The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

heart morphogenesis

The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

cardiac conduction system development

cardiac chamber development

The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.

embryonic heart tube development

cardiac cell differentiation

The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.

muscle tissue development

The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.

actin filament-based movement

Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.

cardiac muscle cell development

The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.

striated muscle cell development

cardiac muscle cell differentiation

The process whereby a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.

myofibril assembly

Formation of myofibrils, the repeating units of striated muscle.

skeletal muscle contraction

regulation of striated muscle contraction

Any process that modulates the frequency, rate or extent of striated muscle contraction.

regulation of heart contraction

cardiac muscle contraction

Muscle contraction of cardiac muscle tissue.

cardiac left ventricle formation

The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts.

ventricular cardiac muscle tissue morphogenesis

The process by which the anatomical structures of cardiac ventricle muscle is generated and organized. Morphogenesis pertains to the creation of form.

cardiac muscle tissue development

The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.

cardiac muscle cell differentiation

The process whereby a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.

cardiac muscle tissue morphogenesis

The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.

ventricular cardiac muscle tissue morphogenesis

The process by which the anatomical structures of cardiac ventricle muscle is generated and organized. Morphogenesis pertains to the creation of form.

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Move the mouse cursor over the terms to get their definition. Clicking on them takes you to the corresponding Gene Ontology web page.

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plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

contractile fiber

Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

muscle myosin complex

A filament of myosin found in a muscle cell of any type.

actin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.

dystrophin-associated glycoprotein complex

A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase.

dystroglycan complex

A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.

sarcoglycan complex

A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex.

myosin complex

A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.

myosin II complex

A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures.

myofibril

The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.

sarcomere

The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

Z disc

Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

A band

The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.

I band

A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.

myosin filament

A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

sarcolemma

The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

contractile fiber part

Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

all

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

intracellular part

membrane part

intracellular organelle

intracellular organelle part

dystroglycan complex

sarcoglycan complex

myosin complex

A band

The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.

I band

Z disc

Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

contractile fiber

Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

contractile fiber part

Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

dystrophin-associated glycoprotein complex

dystroglycan complex

sarcoglycan complex

muscle myosin complex

A filament of myosin found in a muscle cell of any type.

contractile fiber part

Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

cytoskeletal part

sarcomere

The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

myosin complex

HELP

This is one of three sections showing Gene Ontology enrichment of the current module: in this case for molecular function.

Move the mouse cursor over the terms to get their definition. Clicking on them takes you to the corresponding Gene Ontology web page.

If you cannot see a graph here at all, that means that there were no significantly enriched GO categories, at the 0.05 level.

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color bar

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

actin binding

Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.

actin monomer binding

Interacting selectively and non-covalently with monomeric actin, also known as G-actin.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

protein kinase activity

Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

protein serine/threonine kinase activity

Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate.

myosin light chain kinase activity

Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate.

structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

cytoskeletal protein binding

Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).

structural constituent of muscle

The action of a molecule that contributes to the structural integrity of a muscle fiber.

kinase activity

Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

transferase activity

Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

transferase activity, transferring phosphorus-containing groups

Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).

phosphotransferase activity, alcohol group as acceptor

Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).

myosin binding

Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.

titin binding

Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.

myosin heavy chain binding

Interacting selectively and non-covalently with a heavy chain of a myosin complex.

all

protein kinase activity

Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

HELP

List of all enriched GO categories (biological processes), at the 0.05 p-value level.

The columns:

ExpCount is the expected count of genes in the module annotated with the given GO term, just by chance.
Count is the number of genes in the module annotated with the given GO term.
Size is the total number of genes (in our universe) annotated with the GO term.

Clicking on Count shows the genes that drive the enrichment. You can also click on the individual numbers in the Count column, to show the driving genes for that individual GO category.

Clicking on the GO identifiers takes you to the Gene Ontology web pages.

— Click on the Help button again to close this help window.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0003012	2.601e-10	2.522	20	177	muscle system process
GO:0007507	3.628e-10	2.893	21	203	heart development
GO:0006936	5.404e-10	2.323	19	163	muscle contraction
GO:0048738	5.455e-09	0.8122	12	57	cardiac muscle tissue development
GO:0006941	1.059e-08	0.6697	11	47	striated muscle contraction
GO:0003007	2.388e-08	1.154	13	81	heart morphogenesis
GO:0061061	1.024e-07	3.634	20	255	muscle structure development
GO:0055008	1.180e-07	0.3277	8	23	cardiac muscle tissue morphogenesis
GO:0060415	1.180e-07	0.3277	8	23	muscle tissue morphogenesis
GO:0007517	2.224e-07	3.035	18	213	muscle organ development
GO:0003015	2.453e-06	1.154	11	81	heart process
GO:0060047	2.453e-06	1.154	11	81	heart contraction
GO:0003206	2.612e-06	0.4845	8	34	cardiac chamber morphogenesis
GO:0003208	5.182e-06	0.3562	7	25	cardiac ventricle morphogenesis
GO:0003205	6.051e-06	0.5415	8	38	cardiac chamber development
GO:0014706	7.144e-06	1.924	13	135	striated muscle tissue development
GO:0060537	1.232e-05	2.023	13	142	muscle tissue development
GO:0003229	1.402e-05	0.2565	6 HAND1, MYBPC3, MYH7, MYL2, MYL3, NKX2-5	18	ventricular cardiac muscle tissue development
GO:0055010	1.402e-05	0.2565	6 HAND1, MYBPC3, MYH7, MYL2, MYL3, NKX2-5	18	ventricular cardiac muscle tissue morphogenesis
GO:0003231	1.774e-05	0.4275	7	30	cardiac ventricle development
GO:0009888	1.954e-05	8.906	27	625	tissue development
GO:0035051	2.197e-05	0.4417	7	31	cardiac cell differentiation
GO:0048729	2.420e-05	3.363	16	236	tissue morphogenesis
GO:0048513	5.049e-05	21.54	45	1512	organ development
GO:0003013	9.698e-05	2.893	14	203	circulatory system process
GO:0008015	9.698e-05	2.893	14	203	blood circulation
GO:0003010	2.217e-04	0.04275	3 MB, MYLK2, TNNT1	3	voluntary skeletal muscle contraction
GO:0003207	2.217e-04	0.04275	3 HAND1, NKX2-5, TBX5	3	cardiac chamber formation
GO:0003211	2.217e-04	0.04275	3 HAND1, NKX2-5, TBX5	3	cardiac ventricle formation
GO:0014721	2.217e-04	0.04275	3 MB, MYLK2, TNNT1	3	twitch skeletal muscle contraction
GO:0003008	2.322e-04	14.22	33	998	system process
GO:0009887	3.773e-04	7.524	22	528	organ morphogenesis
GO:0009653	5.331e-04	14.86	33	1043	anatomical structure morphogenesis
GO:0090257	5.858e-04	1.04	8	73	regulation of muscle system process
GO:0006942	6.237e-04	0.2992	5 MYBPC3, MYL2, MYL3, MYLK2, NKX2-5	21	regulation of striated muscle contraction
GO:0048646	6.416e-04	5.529	18	388	anatomical structure formation involved in morphogenesis
GO:0055007	7.686e-04	0.3135	5 FHL2, MYL2, NKX2-5, TBX5, XIRP1	22	cardiac muscle cell differentiation
GO:0060048	9.392e-04	0.3277	5 MYBPC3, MYL3, MYLK2, NKX2-5, TCAP	23	cardiac muscle contraction
GO:0030029	1.135e-03	3.206	13	225	actin filament-based process
GO:0044057	1.136e-03	3.691	14	259	regulation of system process
GO:0055006	1.482e-03	0.1852	4 FHL2, MYL2, NKX2-5, XIRP1	13	cardiac cell development
GO:0055013	1.482e-03	0.1852	4 FHL2, MYL2, NKX2-5, XIRP1	13	cardiac muscle cell development
GO:0001947	1.895e-03	0.3847	5 BBS5, HAND1, NKX2-5, SOX17, TBX20	27	heart looping
GO:0003143	1.895e-03	0.3847	5 BBS5, HAND1, NKX2-5, SOX17, TBX20	27	embryonic heart tube morphogenesis
GO:0003009	1.942e-03	0.1995	4 MB, MYLK2, TCAP, TNNT1	14	skeletal muscle contraction
GO:0006937	1.969e-03	0.9262	7	65	regulation of muscle contraction
GO:0008016	2.316e-03	0.9547	7	67	regulation of heart contraction
GO:0042692	2.786e-03	1.724	9	121	muscle cell differentiation
GO:0030239	3.118e-03	0.228	4 MYL2, NKX2-5, TCAP, XIRP1	16	myofibril assembly
GO:0032501	4.366e-03	47.02	69	3300	multicellular organismal process
GO:0048514	4.368e-03	3.235	12	227	blood vessel morphogenesis
GO:0015669	4.410e-03	0.09974	3 AQP1, CYGB, RHAG	7	gas transport
GO:0035050	5.574e-03	0.4987	5 BBS5, HAND1, NKX2-5, SOX17, TBX20	35	embryonic heart tube development
GO:0048856	5.944e-03	30.74	50	2157	anatomical structure development
GO:0048731	6.660e-03	28.38	47	1992	system development
GO:0031032	6.771e-03	0.285	4 MYL2, NKX2-5, TCAP, XIRP1	20	actomyosin structure organization
GO:0003161	8.166e-03	0.0285	2 NKX2-5, TBX5	2	cardiac conduction system development
GO:0003164	8.166e-03	0.0285	2 NKX2-5, TBX5	2	His-Purkinje system development
GO:0003166	8.166e-03	0.0285	2 NKX2-5, TBX5	2	bundle of His development
GO:0003218	8.166e-03	0.0285	2 HAND1, TBX5	2	cardiac left ventricle formation
GO:0031444	8.166e-03	0.0285	2 MB, TNNT1	2	slow-twitch skeletal muscle fiber contraction
GO:0007512	8.859e-03	0.1282	3 MYH7, NKX2-5, TCAP	9	adult heart development
GO:0030049	8.859e-03	0.1282	3 MYBPC3, MYH7, MYLK2	9	muscle filament sliding
GO:0033275	8.859e-03	0.1282	3 MYBPC3, MYH7, MYLK2	9	actin-myosin filament sliding
GO:0070252	8.859e-03	0.1282	3 MYBPC3, MYH7, MYLK2	9	actin-mediated cell contraction
GO:0050879	9.282e-03	0.3135	4 MB, MYLK2, TCAP, TNNT1	22	multicellular organismal movement
GO:0050881	9.282e-03	0.3135	4 MB, MYLK2, TCAP, TNNT1	22	musculoskeletal movement
GO:0055001	1.005e-02	0.8977	6	63	muscle cell development
GO:0002009	1.021e-02	2.593	10	182	morphogenesis of an epithelium
GO:0035295	1.048e-02	3.106	11	218	tube development
GO:0051146	1.077e-02	1.282	7	90	striated muscle cell differentiation
GO:0001568	1.350e-02	3.762	12	264	blood vessel development
GO:0001525	1.427e-02	2.736	10	192	angiogenesis
GO:0007275	1.582e-02	34	52	2386	multicellular organismal development
GO:0001944	1.759e-02	3.904	12	274	vasculature development
GO:0010927	1.766e-02	0.3847	4 MYL2, NKX2-5, TCAP, XIRP1	27	cellular component assembly involved in morphogenesis
GO:0032971	1.925e-02	0.04275	2 MYBPC3, MYLK2	3	regulation of muscle filament sliding
GO:0055011	1.925e-02	0.04275	2 FHL2, NKX2-5	3	atrial cardiac muscle cell differentiation
GO:0055014	1.925e-02	0.04275	2 FHL2, NKX2-5	3	atrial cardiac muscle cell development
GO:0060911	1.925e-02	0.04275	2 NKX2-5, SOX17	3	cardiac cell fate commitment
GO:0030036	2.546e-02	3.021	10	212	actin cytoskeleton organization
GO:0003279	2.607e-02	0.1995	3 HAND1, NKX2-5, TBX5	14	cardiac septum development
GO:0032502	2.985e-02	36.99	54	2596	developmental process
GO:0071300	3.031e-02	0.2137	3 AQP1, WNT11, WNT9A	15	cellular response to retinoic acid
GO:0055002	3.092e-02	0.798	5 ITGB1BP3, MYL2, NKX2-5, TCAP, XIRP1	56	striated muscle cell development
GO:0015670	3.127e-02	0.057	2 AQP1, RHAG	4	carbon dioxide transport
GO:0055003	3.127e-02	0.057	2 MYL2, NKX2-5	4	cardiac myofibril assembly
GO:0071299	3.493e-02	0.228	3 AQP1, WNT11, WNT9A	16	cellular response to vitamin A
GO:0002026	3.987e-02	0.2422	3 ATP2A2, CSRP3, MYL3	17	regulation of the force of heart contraction
GO:0010035	4.458e-02	2.793	9	196	response to inorganic substance
GO:0051890	4.507e-02	0.07125	2 NKX2-5, TBX5	5	regulation of cardioblast differentiation
GO:0051891	4.507e-02	0.07125	2 NKX2-5, TBX5	5	positive regulation of cardioblast differentiation
GO:0030048	4.530e-02	0.2565	3 MYBPC3, MYH7, MYLK2	18	actin filament-based movement

HELP

List of all enriched GO categories (cellular components), at the 0.05 p-value level.

The columns:

ExpCount is the expected count of genes in the module annotated with the given GO term, just by chance.
Count is the number of genes in the module annotated with the given GO term.
Size is the total number of genes (in our universe) annotated with the GO term.

Clicking on Count shows the genes that drive the enrichment. You can also click on the individual numbers in the Count column, to show the driving genes for that individual GO category.

Clicking on the GO identifiers takes you to the Gene Ontology web pages.

— Click on the Help button again to close this help window.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0030017	4.497e-12	0.9966	15	74	sarcomere
GO:0030016	4.054e-11	1.158	15	86	myofibril
GO:0044449	4.054e-11	1.158	15	86	contractile fiber part
GO:0043292	1.397e-10	1.266	15	94	contractile fiber
GO:0031674	3.417e-06	0.5791	8	43	I band
GO:0042383	4.860e-05	0.835	8	62	sarcolemma
GO:0031672	1.625e-04	0.1347	4 FHL2, MYBPC3, MYL3, SMPX	10	A band
GO:0030018	1.653e-04	0.4714	6 CSRP3, FHL2, FLNC, MYOZ2, PDLIM3, TCAP	35	Z disc
GO:0015629	6.593e-04	2.869	12	213	actin cytoskeleton
GO:0016011	9.674e-04	0.0808	3 SGCA, SGCD, SGCG	6	dystroglycan complex
GO:0016012	9.674e-04	0.0808	3 SGCA, SGCD, SGCG	6	sarcoglycan complex
GO:0032982	4.362e-03	0.1347	3 MYBPC3, MYH7, MYOM2	10	myosin filament
GO:0005856	4.830e-03	13.33	27	990	cytoskeleton
GO:0016459	5.193e-03	0.606	5 MYBPC3, MYH7, MYL2, MYL3, MYOM2	45	myosin complex
GO:0005859	8.968e-03	0.1751	3 MYBPC3, MYH7, MYL3	13	muscle myosin complex
GO:0016460	1.088e-02	0.1885	3 MYBPC3, MYH7, MYL3	14	myosin II complex
GO:0033018	1.400e-02	0.05387	2 CASQ2, HRC	4	sarcoplasmic reticulum lumen
GO:0016010	1.525e-02	0.2155	3 SGCA, SGCD, SGCG	16	dystrophin-associated glycoprotein complex
GO:0005886	2.743e-02	35.34	51	2624	plasma membrane
GO:0031430	2.952e-02	0.0808	2 FHL2, SMPX	6	M band
GO:0044459	3.942e-02	21.44	34	1592	plasma membrane part

HELP

List of all enriched GO categories (molecular function), at the 0.05 p-value level.

The columns:

ExpCount is the expected count of genes in the module annotated with the given GO term, just by chance.
Count is the number of genes in the module annotated with the given GO term.
Size is the total number of genes (in our universe) annotated with the GO term.

Clicking on Count shows the genes that drive the enrichment. You can also click on the individual numbers in the Count column, to show the driving genes for that individual GO category.

Clicking on the GO identifiers takes you to the Gene Ontology web pages.

— Click on the Help button again to close this help window.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0008307	6.149e-07	0.4213	8	29	structural constituent of muscle
GO:0008092	6.454e-05	5.681	20	391	cytoskeletal protein binding
GO:0032036	1.316e-03	0.07264	3 MYBPC3, MYL2, MYL3	5	myosin heavy chain binding
GO:0031432	2.365e-03	0.08717	3 MYBPC3, TCAP, TRIM63	6	titin binding
GO:0003779	2.962e-03	3.661	13	252	actin binding
GO:0003785	3.732e-03	0.1017	3 MYL2, MYL3, NOS3	7	actin monomer binding
GO:0017022	5.863e-03	0.2906	4 MYBPC3, MYL2, MYL3, MYLK2	20	myosin binding
GO:0004687	6.799e-03	0.02906	2 MYLK2, MYLK3	2	myosin light chain kinase activity
GO:0005523	1.592e-02	0.1743	3 LMOD2, LMOD3, TNNT1	12	tropomyosin binding
GO:0004111	1.637e-02	0.04359	2 CKM, CKMT2	3	creatine kinase activity
GO:0005198	1.894e-02	5.23	14	360	structural molecule activity
GO:0016775	2.312e-02	0.2034	3 CKM, CKMT2, PDK4	14	phosphotransferase activity, nitrogenous group as acceptor
GO:0005509	3.434e-02	6.988	16	481	calcium ion binding
GO:0005111	3.991e-02	0.07264	2 FGF18, FGF7	5	type 2 fibroblast growth factor receptor binding
GO:0019825	4.624e-02	0.276	3 CYGB, CYP4B1, MB	19	oxygen binding
GO:0020037	4.897e-02	0.9589	5 CYGB, CYP4B1, MB, NOS3, TPO	66	heme binding

HELP

List of all enriched KEGG pathways, at the 0.05 p-value level.

The columns:

ExpCount is the expected count of genes in the module annotated with the given KEGG pathway, just by chance.
Count is the number of genes in the module annotated with the given KEGG pathway.
Size is the total number of genes (in our universe) annotated with the KEGG pathway.

Clicking on Count shows the genes that drive the enrichment. You can also click on the individual numbers in the Count column, to show the driving genes for that individual KEGG pathway.

Clicking on the KEGG identifiers takes you to the KEGG web site.

— Click on the Help button again to close this help window.

Id	Pvalue	ExpCount	Count	Size	Term
05414	7.806e-06	1.145	10	72	Dilated cardiomyopathy
05410	5.199e-05	1.097	9	69	Hypertrophic cardiomyopathy (HCM)
05412	7.993e-03	0.9541	6 ATP2A2, ITGA7, PKP2, SGCA, SGCD, SGCG	60	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
04260	2.670e-02	0.8428	5 ATP2A2, COX6A2, MYH7, MYL2, MYL3	53	Cardiac muscle contraction
04916	2.985e-02	1.288	6	81	Melanogenesis
05416	4.746e-02	0.6043	4 MYH7, SGCA, SGCD, SGCG	38	Viral myocarditis

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List of all enriched miRNA families, at the 0.05 p-value level.

The columns:

ExpCount is the expected count of genes in the module regulated by the given miRNA family, just by chance.
Count is the number of genes in the module regulated by the given miRNA family.
Size is the total number of genes (in our universe) regulated with the given miRNA family.

Clicking on Count shows the genes that drive the enrichment. You can also click on the individual numbers in the Count column, to show the driving genes for that individual miRNA family.

The miRNA regulation data was taken from the TargetScan database. (Only the conserved sites were used for the current analysis.) Clicking on the miRNA names takes you to the TargetScan web site.

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List of all enriched Chromosomes, at the 0.05 p-value level.

The columns:

ExpCount is the expected number of genes in the module on the given chromosome, just by chance.
Count is the number of genes in the module on the given chromosome.
Size is the total number of genes (in our universe) on the given chromosome.

Clicking on Count shows the genes that drive the enrichment. You can also click on the individual numbers in the Count column, to show the driving genes for that individual chromosome.

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A list of all genes in the current module, in alphabetical order. The size of the text corresponds to the gene scores.

Text color indicates correlation and anti-correlation: genes of the same color are correlated, both move up or down in the module samples (listed below). Genes of different color are anti-correlated, they have opposite behavior in the module samples.

Note, that text color of the individual genes should be interpreted together with the coloring of the samples below. For red samples, red genes have a higher expression (compared to the average gene expression level), green genes have a lower expression.

Green samples have opposite behavior, in these red genes have a lower expression, green genes have a higher expression.

Note that some gene symbols may show up more than once, if many probes match the same Entrez gene.

Genes with no Entrez mapping are given separately, with their Affymetrics probe ID.

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Conditions in the module, given in the same order as on the expression plot above. Red color means over-expression, green under-expression in the given condition.

The barplot below shows the condition (sample) scores. A separate bar is shown for each sample, its height is the corresponding score of the sample in the module. The red and green numbers on the bars are the sample scores expressed in percents, i.e. 100% is 1.0.

The height of each bar corresponds to the weighted mean expression of the module genes. The weights are the gene scores of the module and they are positive for the genes listed in red above and they are negative for the genes that are listed in green.

Bars going up correspond to samples listed in red (the ones that are different enough to included in the module). In these samples the red module genes are highly expressed, and the green module genes are lowly expressed. The behavior of the genes is the opposite for bars going down.

The red and green lines show the module thresholds, samples above the red line and below the green line are included in the module.

The different species and tissues that were part of the study, are separated by dashed vertical lines.

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Id	species	tissue	sex	individual
hsa_ht_m2_ca1	hsa	ht	m	2
hsa_ht_f_ca1	hsa	ht	f	_
hsa_ht_m1_ca1	hsa	ht	m	1

Previous module | Next module Module #51, TG: 2.6, TC: 2.6, 175 probes, 175 Entrez genes, 3 conditions

Help | Hide | Top Help | Show | Top Expression data

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Help | Hide | Top Help | Show | Top The GO tree — Biological processes

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Help | Hide | Top Help | Show | Top The GO tree — Cellular Components

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Help | Hide | Top Help | Show | Top The GO tree — Molecular Function

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Help | Hide | Top Help | Show | Top GO BP test for over-representation

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Help | Hide | Top Help | Show | Top GO CC test for over-representation

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Help | Hide | Top Help | Show | Top GO MF test for over-representation

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Help | Hide | Top Help | Show | Top KEGG Pathway test for over-representation

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Help | Hide | Top Help | Show | Top miRNA test for over-representation

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Help | Hide | Top Help | Show | Top Chromosome test for over-representation

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Help | Hide | Top Help | Show | Top Genes

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Entrez genes

Non-Entrez genes

Help | Hide | Top Help | Show | Top Conditions

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