Under-expression is coded with green,
over-expression with red color.
urea cycle
A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
system process
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
alcohol metabolic process
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
organic acid metabolic process
The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
purine base metabolic process
The chemical reactions and pathways involving purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
purine base catabolic process
The chemical reactions and pathways resulting in the breakdown of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
arginine metabolic process
The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
cellular amino acid derivative metabolic process
The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
cellular biogenic amine metabolic process
The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
lipid metabolic process
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
phospholipid metabolic process
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
glycerophospholipid metabolic process
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
cellular aromatic compound metabolic process
The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
transport
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.
lipid transport
The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
digestion
The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
steroid metabolic process
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
cholesterol metabolic process
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
androgen metabolic process
The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.
lipid biosynthetic process
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
biosynthetic process
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
glutamine family amino acid metabolic process
The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
nucleobase metabolic process
The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine.
amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
response to drug
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
phospholipid catabolic process
The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
response to external stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
response to endogenous stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.
response to hormone stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
response to extracellular stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
response to organic substance
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
regulation of hormone levels
Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.
lipid localization
Any process by which a lipid is transported to, or maintained in, a specific location.
sterol transport
The directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
lipid catabolic process
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
sterol metabolic process
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
drug metabolic process
The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.
organic ether metabolic process
The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds.
urea metabolic process
The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2, produced in the liver by the ornithine cycle. It is the main nitrogen-containing excretion product in ureotelic animals.
organophosphate metabolic process
The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound.
carboxylic acid metabolic process
The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
digestive system process
A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
intestinal cholesterol absorption
Uptake of cholesterol into the blood by absorption from the small intestine.
cholesterol transport
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells by means of some external agent such as a transporter or pore.
response to nutrient levels
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
monocarboxylic acid metabolic process
The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).
macromolecule localization
Any process by which a macromolecule is transported to, or maintained in, a specific location.
cholesterol efflux
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
phosphatidylcholine catabolic process
The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
nucleobase, nucleoside and nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides and nucleotides.
cellular hormone metabolic process
The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells.
cellular ketone metabolic process
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
response to chemical stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
ethanolamine and derivative metabolic process
The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it.
hormone metabolic process
The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
homeostatic process
Any biological process involved in the maintenance of an internal steady-state.
cholesterol homeostasis
Any process involved in the maintenance of an internal steady-state of cholesterol within an organism or cell.
drug catabolic process
The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease.
exogenous drug catabolic process
The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism.
oxoacid metabolic process
The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
cellular amide metabolic process
The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.
amide biosynthetic process
The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
cellular amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
lipid digestion
The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.
cellular lipid catabolic process
The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular lipid metabolic process
The chemical reactions and pathways involving lipids, as carried out by individual cells.
cellular nitrogen compound catabolic process
The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds.
cellular nitrogen compound biosynthetic process
The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.
small molecule metabolic process
The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
nucleobase catabolic process
The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid.
phosphatidylcholine metabolic process
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
glycerophospholipid catabolic process
The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
heterocycle metabolic process
The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
glycerolipid metabolic process
The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.
glycerolipid catabolic process
The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone.
heterocycle catabolic process
The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
response to steroid hormone stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
chemical homeostasis
Any biological process involved in the maintenance of an internal steady-state of a chemical.
intestinal absorption
Any process by which nutrients are taken up from the contents of the intestine.
response to stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
localization
Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
nucleobase, nucleoside and nucleotide metabolic process
The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.
lipid homeostasis
Any process involved in the maintenance of an internal steady-state of lipid within an organism or cell.
sterol homeostasis
Any process involved in the maintenance of an internal steady-state of sterol within an organism or cell.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
regulation of biological quality
Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
all
NA
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
cellular hormone metabolic process
The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
organic acid metabolic process
The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
cellular ketone metabolic process
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
digestive system process
A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
cellular amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
cellular lipid catabolic process
The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.
cellular nitrogen compound catabolic process
The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds.
cellular nitrogen compound biosynthetic process
The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.
drug catabolic process
The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease.
oxoacid metabolic process
The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
phospholipid metabolic process
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
cellular lipid catabolic process
The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.
nucleobase metabolic process
The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine.
heterocycle catabolic process
The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
nucleobase, nucleoside and nucleotide metabolic process
The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.
lipid biosynthetic process
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
lipid catabolic process
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
cellular lipid metabolic process
The chemical reactions and pathways involving lipids, as carried out by individual cells.
nucleobase metabolic process
The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine.
nucleobase, nucleoside and nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides and nucleotides.
response to hormone stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
lipid transport
The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
hormone metabolic process
The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
urea metabolic process
The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2, produced in the liver by the ornithine cycle. It is the main nitrogen-containing excretion product in ureotelic animals.
nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
amide biosynthetic process
The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
phospholipid catabolic process
The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.
exogenous drug catabolic process
The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism.
nucleobase catabolic process
The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid.
glycerophospholipid catabolic process
The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
cellular biogenic amine metabolic process
The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
nucleobase catabolic process
The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid.
glycerophospholipid metabolic process
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
glycerolipid catabolic process
The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone.
nucleobase, nucleoside and nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides and nucleotides.
androgen metabolic process
The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.
sterol metabolic process
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
phosphatidylcholine metabolic process
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
intestinal cholesterol absorption
Uptake of cholesterol into the blood by absorption from the small intestine.
ethanolamine and derivative metabolic process
The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it.
urea cycle
A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.
glycerophospholipid catabolic process
The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
phosphatidylcholine catabolic process
The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
purine base catabolic process
The chemical reactions and pathways resulting in the breakdown of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
intestinal cholesterol absorption
Uptake of cholesterol into the blood by absorption from the small intestine.
cell fraction
A generic term for parts of cells prepared by disruptive biochemical techniques.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
extracellular space
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
membrane fraction
That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes.
insoluble fraction
That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water.
microsome
Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g.
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
protein-lipid complex
A macromolecular complex containing both protein and lipid molecules.
plasma lipoprotein particle
A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.
high-density lipoprotein particle
A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.
vesicular fraction
Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized.
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
all
NA
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
plasma lipoprotein particle
A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.
plasma lipoprotein particle
A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
catalytic activity
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
transporter activity
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
transmembrane transporter activity
Enables the transfer of a substance from one side of a membrane to the other.
organic acid transmembrane transporter activity
Catalysis of the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other.
secondary active transmembrane transporter activity
Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.
binding
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
oxidoreductase activity
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
lipid binding
Interacting selectively and non-covalently with a lipid.
monocarboxylic acid transmembrane transporter activity
Catalysis of the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group.
kinase activity
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
oxidoreductase activity, acting on the CH-CH group of donors
Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.
transferase activity
Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
transferase activity, transferring phosphorus-containing groups
Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
carbohydrate kinase activity
Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule.
active transmembrane transporter activity
Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
substrate-specific transporter activity
Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
carboxylic acid binding
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
carboxylic acid transmembrane transporter activity
Catalysis of the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).
all
NA
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 01100 | 2.072e-03 | 7.974 | 19 | 805 | Metabolic pathways |
| 00232 | 1.266e-02 | 0.03962 | 2 | 4 | Caffeine metabolism |
| 04610 | 2.647e-02 | 0.4953 | 4 | 50 | Complement and coagulation cascades |
| 00830 | 3.211e-02 | 0.2477 | 3 | 25 | Retinol metabolism |
| 00980 | 3.528e-02 | 0.2576 | 3 | 26 | Metabolism of xenobiotics by cytochrome P450 |
ABCG5ATP-binding cassette, sub-family G (WHITE), member 5 (ENSG00000138075), score: 0.81 ADH4alcohol dehydrogenase 4 (class II), pi polypeptide (ENSG00000198099), score: 0.8 AGXTalanine-glyoxylate aminotransferase (ENSG00000172482), score: 0.78 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.83 APOC1apolipoprotein C-I (ENSG00000130208), score: 0.78 APOFapolipoprotein F (ENSG00000175336), score: 0.87 AQP9aquaporin 9 (ENSG00000103569), score: 0.78 ARG1arginase, liver (ENSG00000118520), score: 0.8 ART4ADP-ribosyltransferase 4 (Dombrock blood group) (ENSG00000111339), score: 0.78 C14orf21chromosome 14 open reading frame 21 (ENSG00000196943), score: 0.85 C20orf194chromosome 20 open reading frame 194 (ENSG00000088854), score: -0.8 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.8 C8Bcomplement component 8, beta polypeptide (ENSG00000021852), score: 0.79 CIDEBcell death-inducing DFFA-like effector b (ENSG00000136305), score: 0.83 CLDN14claudin 14 (ENSG00000159261), score: 0.84 CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 2 (ENSG00000140505), score: 0.81 DPYDdihydropyrimidine dehydrogenase (ENSG00000188641), score: 0.77 DSC3desmocollin 3 (ENSG00000134762), score: 0.78 EI24etoposide induced 2.4 mRNA (ENSG00000149547), score: 0.83 EPHX1epoxide hydrolase 1, microsomal (xenobiotic) (ENSG00000143819), score: 0.78 ESR1estrogen receptor 1 (ENSG00000091831), score: 0.8 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.77 F2RL2coagulation factor II (thrombin) receptor-like 2 (ENSG00000164220), score: 0.8 F7coagulation factor VII (serum prothrombin conversion accelerator) (ENSG00000057593), score: 0.77 FETUBfetuin B (ENSG00000090512), score: 0.88 FOXA1forkhead box A1 (ENSG00000129514), score: 0.89 GCKglucokinase (hexokinase 4) (ENSG00000106633), score: 0.87 GCKRglucokinase (hexokinase 4) regulator (ENSG00000084734), score: 0.78 GDF2growth differentiation factor 2 (ENSG00000128802), score: 0.79 GLYATL3glycine-N-acyltransferase-like 3 (ENSG00000203972), score: 0.97 GNAT1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 (ENSG00000114349), score: 0.79 GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (ENSG00000159921), score: 0.78 GPAMglycerol-3-phosphate acyltransferase, mitochondrial (ENSG00000119927), score: 0.83 GPLD1glycosylphosphatidylinositol specific phospholipase D1 (ENSG00000112293), score: 0.81 GUCA2Bguanylate cyclase activator 2B (uroguanylin) (ENSG00000044012), score: 1 GYS2glycogen synthase 2 (liver) (ENSG00000111713), score: 0.84 HAO1hydroxyacid oxidase (glycolate oxidase) 1 (ENSG00000101323), score: 0.79 HSD17B13hydroxysteroid (17-beta) dehydrogenase 13 (ENSG00000170509), score: 0.8 IGFALSinsulin-like growth factor binding protein, acid labile subunit (ENSG00000099769), score: 0.9 INHBCinhibin, beta C (ENSG00000175189), score: 0.79 INHBEinhibin, beta E (ENSG00000139269), score: 0.88 KRT28keratin 28 (ENSG00000173908), score: 0.8 LECT2leukocyte cell-derived chemotaxin 2 (ENSG00000145826), score: 0.83 LIPClipase, hepatic (ENSG00000166035), score: 0.81 LRRC3leucine rich repeat containing 3 (ENSG00000160233), score: 0.79 LRRC31leucine rich repeat containing 31 (ENSG00000114248), score: 0.83 MINPP1multiple inositol-polyphosphate phosphatase 1 (ENSG00000107789), score: 0.8 NIPAL1NIPA-like domain containing 1 (ENSG00000163293), score: 0.82 NPC1L1NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (ENSG00000015520), score: 0.83 NR1I2nuclear receptor subfamily 1, group I, member 2 (ENSG00000144852), score: 0.84 ONECUT2one cut homeobox 2 (ENSG00000119547), score: 0.9 OTCornithine carbamoyltransferase (ENSG00000036473), score: 0.89 OXER1oxoeicosanoid (OXE) receptor 1 (ENSG00000162881), score: 0.78 PEMTphosphatidylethanolamine N-methyltransferase (ENSG00000133027), score: 0.85 PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (ENSG00000158571), score: 0.85 PGLYRP2peptidoglycan recognition protein 2 (ENSG00000161031), score: 0.85 PON1paraoxonase 1 (ENSG00000005421), score: 0.78 PRHOXNBparahox cluster neighbor (ENSG00000183463), score: 0.78 RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (ENSG00000173166), score: 0.8 RDH16retinol dehydrogenase 16 (all-trans) (ENSG00000139547), score: 0.81 SEC14L4SEC14-like 4 (S. cerevisiae) (ENSG00000133488), score: 0.9 SERPINA11serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 (ENSG00000186910), score: 0.79 SERPINA4serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 (ENSG00000100665), score: 0.82 SERPINA7serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 (ENSG00000123561), score: 0.78 SIGMAR1sigma non-opioid intracellular receptor 1 (ENSG00000147955), score: 0.81 SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (ENSG00000100652), score: 0.83 SLC16A11solute carrier family 16, member 11 (monocarboxylic acid transporter 11) (ENSG00000174326), score: 0.78 SLC16A2solute carrier family 16, member 2 (monocarboxylic acid transporter 8) (ENSG00000147100), score: 0.78 SLC17A2solute carrier family 17 (sodium phosphate), member 2 (ENSG00000112337), score: 0.79 SLC19A3solute carrier family 19, member 3 (ENSG00000135917), score: 0.78 SLC22A1solute carrier family 22 (organic cation transporter), member 1 (ENSG00000175003), score: 0.79 SLC25A15solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 (ENSG00000102743), score: 0.8 SLC25A36solute carrier family 25, member 36 (ENSG00000114120), score: -0.81 SLC25A47solute carrier family 25, member 47 (ENSG00000140107), score: 0.79 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.79 SLCO1B1solute carrier organic anion transporter family, member 1B1 (ENSG00000134538), score: 0.82 SLCO1B3solute carrier organic anion transporter family, member 1B3 (ENSG00000111700), score: 0.84 SOAT2sterol O-acyltransferase 2 (ENSG00000167780), score: 0.94 SPP2secreted phosphoprotein 2, 24kDa (ENSG00000072080), score: 0.83 SRD5A2steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (ENSG00000049319), score: 0.83 SYVN1synovial apoptosis inhibitor 1, synoviolin (ENSG00000162298), score: 0.79 TECTBtectorin beta (ENSG00000119913), score: 0.79 THRSPthyroid hormone responsive (ENSG00000151365), score: 0.78 TM4SF4transmembrane 4 L six family member 4 (ENSG00000169903), score: 0.8 TM7SF2transmembrane 7 superfamily member 2 (ENSG00000149809), score: 0.77 TMEM195transmembrane protein 195 (ENSG00000187546), score: 0.84 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.82 TTPALtocopherol (alpha) transfer protein-like (ENSG00000124120), score: 0.79 UROC1urocanase domain containing 1 (ENSG00000159650), score: 0.93 VWCEvon Willebrand factor C and EGF domains (ENSG00000167992), score: 0.95 XDHxanthine dehydrogenase (ENSG00000158125), score: 0.81
| Id | species | tissue | sex | individual |
|---|---|---|---|---|
| ptr_lv_m_ca1 | ptr | lv | m | _ |
| hsa_lv_m2_ca1 | hsa | lv | m | 2 |
| mml_lv_f_ca1 | mml | lv | f | _ |
| hsa_lv_m1_ca1 | hsa | lv | m | 1 |
| mml_lv_m_ca1 | mml | lv | m | _ |
