Under-expression is coded with green,
over-expression with red color.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
heart morphogenesis
The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
system process
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
muscle system process
A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
circulatory system process
A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
heart process
A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
cardiac chamber development
The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.
cardiac chamber morphogenesis
The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
cardiac chamber formation
The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.
cardiac ventricle morphogenesis
The process by which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
cardiac ventricle formation
The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
ventricular cardiac muscle tissue development
The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.
cardiac ventricle development
The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
muscle contraction
A process whereby force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
actin cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
generation of precursor metabolites and energy
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of nucleotide metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
purine nucleotide metabolic process
The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
purine nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
nucleoside phosphate metabolic process
The chemical reactions and pathways involving any phosphorylated nucleoside.
nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
transport
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.
regulation of muscle contraction
Any process that modulates the frequency, rate or extent of muscle contraction.
striated muscle contraction
A process whereby force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
regulation of striated muscle contraction
Any process that modulates the frequency, rate or extent of striated muscle contraction.
cellular membrane fusion
The cellular process that joins two lipid bilayers to form a single membrane.
organelle organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
mitochondrion organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
organ morphogenesis
Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
heart development
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
muscle organ development
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
blood circulation
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
regulation of heart contraction
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body.
mitochondrial fusion
Merging of two or more mitochondria within a cell to form a single compartment.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
nucleotide metabolic process
The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).
nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
regulation of catabolic process
Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
cellular component assembly
The aggregation, arrangement and bonding together of a cellular component.
anatomical structure formation involved in morphogenesis
The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
cellular component assembly involved in morphogenesis
The cellular component assembly that is part of the initial shaping of the component during its developmental progression.
striated muscle tissue development
The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.
energy derivation by oxidation of organic compounds
The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released.
cellular component organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
cellular membrane organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
actin filament-based process
Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
cell differentiation
The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
myofibril assembly
Formation of myofibrils, the repeating units of striated muscle.
cytoskeleton-dependent intracellular transport
The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.
regulation of nucleotide catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.
actomyosin structure organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
regulation of cellular catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
cellular component morphogenesis
The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.
cell part morphogenesis
The process by which the anatomical structures of a cell part are generated and organized. Morphogenesis pertains to the creation of form.
regulation of purine nucleotide catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
nucleobase, nucleoside and nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides and nucleotides.
cardiac cell differentiation
The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.
muscle cell differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell.
regulation of ATPase activity
Any process that modulates the rate of ATP hydrolysis by an ATPase.
regulation of system process
Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
cellular component biogenesis
The process by which a cellular component is synthesized, aggregates, and bonds together. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular nitrogen compound catabolic process
The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds.
small molecule metabolic process
The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
cellular respiration
The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).
heterocycle metabolic process
The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
heterocycle catabolic process
The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
intracellular transport
The directed movement of substances within a cell.
organelle fusion
The creation of a single organelle from two or more organelles.
cell development
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue morphogenesis
The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
cardiac muscle tissue development
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of catalytic activity
Any process that modulates the activity of an enzyme.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
striated muscle cell differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.
regulation of nitrogen compound metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
localization
Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
regulation of hydrolase activity
Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
cellular localization
Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
establishment of localization in cell
The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
muscle cell development
The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
striated muscle cell development
The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.
cardiac myofibril assembly
The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.
cardiac cell development
The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual.
cardiac muscle cell differentiation
The process whereby a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.
ventricular cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac ventricle muscle is generated and organized. Morphogenesis pertains to the creation of form.
cardiac muscle cell development
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
nucleobase, nucleoside and nucleotide metabolic process
The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.
heart contraction
The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.
cardiac muscle contraction
Muscle contraction of cardiac muscle tissue.
muscle tissue morphogenesis
The process by which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. Morphogenesis pertains to the creation of form.
muscle tissue development
The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.
membrane organization
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
membrane fusion
The membrane organization process that joins two lipid bilayers to form a single membrane.
muscle structure development
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
regulation of molecular function
Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
mitochondrion morphogenesis
The process by which the anatomical structures of a mitochondrion are generated and organized. Morphogenesis pertains to the creation of form.
regulation of primary metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
regulation of muscle system process
Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.
all
NA
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
organelle organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
cellular component assembly
The aggregation, arrangement and bonding together of a cellular component.
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
cellular localization
Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of catabolic process
Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.
regulation of nitrogen compound metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
regulation of primary metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
cellular component morphogenesis
The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
establishment of localization in cell
The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
cellular component assembly involved in morphogenesis
The cellular component assembly that is part of the initial shaping of the component during its developmental progression.
cellular membrane organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
regulation of system process
Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
anatomical structure formation involved in morphogenesis
The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
cellular component morphogenesis
The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.
cellular component assembly involved in morphogenesis
The cellular component assembly that is part of the initial shaping of the component during its developmental progression.
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
cell development
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
intracellular transport
The directed movement of substances within a cell.
regulation of catalytic activity
Any process that modulates the activity of an enzyme.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of cellular catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular nitrogen compound catabolic process
The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of cellular catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
heterocycle catabolic process
The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
nucleobase, nucleoside and nucleotide metabolic process
The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.
nucleobase, nucleoside and nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides and nucleotides.
actin cytoskeleton organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
mitochondrial fusion
Merging of two or more mitochondria within a cell to form a single compartment.
cell development
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
mitochondrion morphogenesis
The process by which the anatomical structures of a mitochondrion are generated and organized. Morphogenesis pertains to the creation of form.
cellular membrane fusion
The cellular process that joins two lipid bilayers to form a single membrane.
regulation of muscle system process
Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
cardiac chamber formation
The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.
tissue morphogenesis
The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.
cardiac chamber morphogenesis
The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
tissue morphogenesis
The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.
organ morphogenesis
Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
muscle organ development
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
muscle cell differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell.
nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids.
purine nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
nucleobase, nucleoside and nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides and nucleotides.
mitochondrial fusion
Merging of two or more mitochondria within a cell to form a single compartment.
myofibril assembly
Formation of myofibrils, the repeating units of striated muscle.
cardiac cell development
The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual.
muscle cell development
The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
cardiac muscle cell development
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
regulation of muscle contraction
Any process that modulates the frequency, rate or extent of muscle contraction.
heart contraction
The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.
cardiac ventricle formation
The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
cardiac chamber morphogenesis
The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.
cardiac ventricle morphogenesis
The process by which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
heart morphogenesis
The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
cardiac chamber development
The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.
cardiac cell differentiation
The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.
muscle tissue development
The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.
regulation of nucleotide catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.
regulation of purine nucleotide catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.
purine nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
regulation of nucleotide catabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.
regulation of nucleotide metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
purine nucleotide metabolic process
The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
nucleotide catabolic process
The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
cardiac muscle cell development
The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.
striated muscle cell development
The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.
cardiac muscle cell differentiation
The process whereby a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
myofibril assembly
Formation of myofibrils, the repeating units of striated muscle.
cardiac myofibril assembly
The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.
regulation of striated muscle contraction
Any process that modulates the frequency, rate or extent of striated muscle contraction.
regulation of heart contraction
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body.
cardiac muscle contraction
Muscle contraction of cardiac muscle tissue.
ventricular cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac ventricle muscle is generated and organized. Morphogenesis pertains to the creation of form.
cardiac muscle tissue development
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
cardiac muscle cell differentiation
The process whereby a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.
regulation of ATPase activity
Any process that modulates the rate of ATP hydrolysis by an ATPase.
ventricular cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac ventricle muscle is generated and organized. Morphogenesis pertains to the creation of form.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
contractile fiber
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
mitochondrion
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
endoplasmic reticulum
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
cytoplasm
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial envelope
The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
mitochondrial inner membrane
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial respiratory chain
The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.
endoplasmic reticulum lumen
The volume enclosed by the membranes of the endoplasmic reticulum.
sarcoplasm
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
sarcoplasmic reticulum
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
organelle inner membrane
The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.
myofibril
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
sarcomere
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
Z disc
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
organelle membrane
The lipid bilayer surrounding an organelle.
I band
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
mitochondrial membrane
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
organelle envelope
A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
membrane-enclosed lumen
The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
envelope
A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.
sarcoplasmic reticulum lumen
The volume enclosed by the membranes of the sarcoplasmic reticulum.
sarcolemma
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
organelle lumen
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
mitochondrial part
Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
contractile fiber part
Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
mitochondrial membrane part
Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
intracellular organelle lumen
An organelle lumen that is part of an intracellular organelle.
respiratory chain
The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.
subsynaptic reticulum
An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
all
NA
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
organelle lumen
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
organelle membrane
The lipid bilayer surrounding an organelle.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
organelle envelope
A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
intracellular organelle lumen
An organelle lumen that is part of an intracellular organelle.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
organelle membrane
The lipid bilayer surrounding an organelle.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
organelle envelope
A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
organelle inner membrane
The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
organelle inner membrane
The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.
mitochondrial inner membrane
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial membrane part
Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrial envelope
The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
mitochondrial membrane
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrial membrane part
Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
endoplasmic reticulum lumen
The volume enclosed by the membranes of the endoplasmic reticulum.
I band
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
Z disc
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
contractile fiber
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
mitochondrion
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
endoplasmic reticulum
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
mitochondrial part
Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
contractile fiber part
Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
subsynaptic reticulum
An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
mitochondrial respiratory chain
The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.
mitochondrial membrane
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrial part
Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
sarcoplasmic reticulum
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
contractile fiber part
Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
mitochondrial respiratory chain
The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.
sarcoplasmic reticulum
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
sarcoplasmic reticulum lumen
The volume enclosed by the membranes of the sarcoplasmic reticulum.
sarcomere
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
nucleotide binding
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.
protein binding
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
actin binding
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
catalytic activity
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
structural molecule activity
The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.
binding
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
oxidoreductase activity
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
cytoskeletal protein binding
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
structural constituent of muscle
The action of a molecule that contributes to the structural integrity of a muscle fiber.
oxidoreductase activity, acting on NADH or NADPH
Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
myosin binding
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
titin binding
Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
myosin heavy chain binding
Interacting selectively and non-covalently with a heavy chain of a myosin complex.
cofactor binding
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
coenzyme binding
Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
NAD or NADH binding
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH.
all
NA
NAD or NADH binding
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH.
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 05410 | 9.160e-08 | 1.457 | 13 | 69 | Hypertrophic cardiomyopathy (HCM) |
| 05414 | 1.491e-06 | 1.52 | 12 | 72 | Dilated cardiomyopathy |
| 04260 | 6.261e-06 | 1.119 | 10 | 53 | Cardiac muscle contraction |
| 05012 | 3.345e-03 | 1.52 | 8 | 72 | Parkinson's disease |
| 04910 | 9.193e-03 | 2.281 | 9 | 108 | Insulin signaling pathway |
| 05016 | 9.738e-03 | 2.302 | 9 | 109 | Huntington's disease |
| 00020 | 1.773e-02 | 0.4434 | 4 | 21 | Citrate cycle (TCA cycle) |
| 00190 | 1.990e-02 | 1.605 | 7 | 76 | Oxidative phosphorylation |
| 05412 | 2.822e-02 | 1.267 | 6 | 60 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
ACTC1actin, alpha, cardiac muscle 1 (ENSG00000159251), score: 0.6 ADALadenosine deaminase-like (ENSG00000168803), score: 0.67 ADAM9ADAM metallopeptidase domain 9 (ENSG00000168615), score: 0.57 ADCK5aarF domain containing kinase 5 (ENSG00000173137), score: -0.59 AFG3L2AFG3 ATPase family gene 3-like 2 (S. cerevisiae) (ENSG00000141385), score: 0.57 AIMP1aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (ENSG00000164022), score: 0.61 ANAPC2anaphase promoting complex subunit 2 (ENSG00000176248), score: -0.59 ANKRD1ankyrin repeat domain 1 (cardiac muscle) (ENSG00000148677), score: 0.64 ANO5anoctamin 5 (ENSG00000171714), score: 0.57 AP2A2adaptor-related protein complex 2, alpha 2 subunit (ENSG00000183020), score: -0.67 APOBEC2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 (ENSG00000124701), score: 0.59 ARL6IP5ADP-ribosylation-like factor 6 interacting protein 5 (ENSG00000144746), score: 0.57 ASB11ankyrin repeat and SOCS box-containing 11 (ENSG00000165192), score: 0.65 ASB15ankyrin repeat and SOCS box-containing 15 (ENSG00000146809), score: 0.56 ASB8ankyrin repeat and SOCS box-containing 8 (ENSG00000177981), score: 0.64 ATF6Bactivating transcription factor 6 beta (ENSG00000213676), score: -0.59 ATP13A1ATPase type 13A1 (ENSG00000105726), score: -0.59 ATP5C1ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (ENSG00000165629), score: 0.56 ATP5JATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 (ENSG00000154723), score: 0.55 ATPAF1ATP synthase mitochondrial F1 complex assembly factor 1 (ENSG00000123472), score: 0.61 B3GALTLbeta 1,3-galactosyltransferase-like (ENSG00000187676), score: 0.57 BCL2L13BCL2-like 13 (apoptosis facilitator) (ENSG00000099968), score: 0.71 BECN1beclin 1, autophagy related (ENSG00000126581), score: 0.68 BMPR1Abone morphogenetic protein receptor, type IA (ENSG00000107779), score: 0.59 BVESblood vessel epicardial substance (ENSG00000112276), score: 0.66 BZW2basic leucine zipper and W2 domains 2 (ENSG00000136261), score: 0.69 C10orf71chromosome 10 open reading frame 71 (ENSG00000177354), score: 0.66 C13orf30chromosome 13 open reading frame 30 (ENSG00000179813), score: 0.77 C14orf180chromosome 14 open reading frame 180 (ENSG00000184601), score: 0.58 C15orf52chromosome 15 open reading frame 52 (ENSG00000188549), score: 0.64 C18orf55chromosome 18 open reading frame 55 (ENSG00000075336), score: 0.6 C7orf27chromosome 7 open reading frame 27 (ENSG00000106009), score: -0.64 CAPZA2capping protein (actin filament) muscle Z-line, alpha 2 (ENSG00000198898), score: 0.59 CASQ2calsequestrin 2 (cardiac muscle) (ENSG00000118729), score: 0.64 CASTcalpastatin (ENSG00000153113), score: 0.56 CCDC141coiled-coil domain containing 141 (ENSG00000163492), score: 0.6 CCDC69coiled-coil domain containing 69 (ENSG00000198624), score: 0.57 CCDC93coiled-coil domain containing 93 (ENSG00000125633), score: 0.71 CD274CD274 molecule (ENSG00000120217), score: 0.69 CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) (ENSG00000134371), score: 0.6 CDH2cadherin 2, type 1, N-cadherin (neuronal) (ENSG00000170558), score: 0.59 CGAglycoprotein hormones, alpha polypeptide (ENSG00000135346), score: 0.78 CHST9carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 (ENSG00000154080), score: 0.59 CMA1chymase 1, mast cell (ENSG00000092009), score: 0.57 CMYA5cardiomyopathy associated 5 (ENSG00000164309), score: 0.64 COPS7BCOP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) (ENSG00000144524), score: -0.66 COX7A1cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) (ENSG00000161281), score: 0.57 CScitrate synthase (ENSG00000062485), score: 0.56 CSDE1cold shock domain containing E1, RNA-binding (ENSG00000009307), score: 0.61 CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein) (ENSG00000129170), score: 0.62 CYB5D2cytochrome b5 domain containing 2 (ENSG00000167740), score: -0.65 DAAM1dishevelled associated activator of morphogenesis 1 (ENSG00000100592), score: 0.62 DAND5DAN domain family, member 5 (ENSG00000179284), score: 0.75 DCUN1D5DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) (ENSG00000137692), score: 0.58 DDX1DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 (ENSG00000079785), score: 0.77 DHRS7Cdehydrogenase/reductase (SDR family) member 7C (ENSG00000184544), score: 0.63 DIRC2disrupted in renal carcinoma 2 (ENSG00000138463), score: 0.75 DISC1disrupted in schizophrenia 1 (ENSG00000162946), score: 0.62 DLDdihydrolipoamide dehydrogenase (ENSG00000091140), score: 0.57 DNAJC13DnaJ (Hsp40) homolog, subfamily C, member 13 (ENSG00000138246), score: 0.58 DOLPP1dolichyl pyrophosphate phosphatase 1 (ENSG00000167130), score: -0.65 DUSP27dual specificity phosphatase 27 (putative) (ENSG00000198842), score: 0.59 EFHC2EF-hand domain (C-terminal) containing 2 (ENSG00000183690), score: 0.57 EGLN3egl nine homolog 3 (C. elegans) (ENSG00000129521), score: 0.55 EIF1Beukaryotic translation initiation factor 1B (ENSG00000114784), score: 0.67 EIF4G2eukaryotic translation initiation factor 4 gamma, 2 (ENSG00000110321), score: 0.77 ELMOD3ELMO/CED-12 domain containing 3 (ENSG00000115459), score: -0.58 ENTPD1ectonucleoside triphosphate diphosphohydrolase 1 (ENSG00000138185), score: 0.61 ERAP1endoplasmic reticulum aminopeptidase 1 (ENSG00000164307), score: 0.55 EREGepiregulin (ENSG00000124882), score: 0.88 ESYT2extended synaptotagmin-like protein 2 (ENSG00000117868), score: 0.56 EXOGendo/exonuclease (5'-3'), endonuclease G-like (ENSG00000157036), score: 0.57 FAIM3Fas apoptotic inhibitory molecule 3 (ENSG00000162894), score: 0.64 FAM113Afamily with sequence similarity 113, member A (ENSG00000132635), score: -0.67 FAM129Afamily with sequence similarity 129, member A (ENSG00000135842), score: 0.67 FASTKD2FAST kinase domains 2 (ENSG00000118246), score: 0.56 FBXL7F-box and leucine-rich repeat protein 7 (ENSG00000183580), score: 0.59 FBXO32F-box protein 32 (ENSG00000156804), score: 0.61 FBXO40F-box protein 40 (ENSG00000163833), score: 0.69 FGD6FYVE, RhoGEF and PH domain containing 6 (ENSG00000180263), score: 0.59 FGF18fibroblast growth factor 18 (ENSG00000156427), score: 0.78 FGFR3fibroblast growth factor receptor 3 (ENSG00000068078), score: -0.63 FILIP1filamin A interacting protein 1 (ENSG00000118407), score: 0.63 FSD2fibronectin type III and SPRY domain containing 2 (ENSG00000186628), score: 0.73 FYTTD1forty-two-three domain containing 1 (ENSG00000122068), score: 0.64 GAB3GRB2-associated binding protein 3 (ENSG00000160219), score: 0.59 GADL1glutamate decarboxylase-like 1 (ENSG00000144644), score: 0.92 GCOM1GRINL1A complex locus (ENSG00000137878), score: 0.69 GGHgamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) (ENSG00000137563), score: -0.58 GHITMgrowth hormone inducible transmembrane protein (ENSG00000165678), score: 0.56 GIMAP8GTPase, IMAP family member 8 (ENSG00000171115), score: 0.55 GRINAglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) (ENSG00000178719), score: -0.58 GRSF1G-rich RNA sequence binding factor 1 (ENSG00000132463), score: 0.57 GYG1glycogenin 1 (ENSG00000163754), score: 0.57 HADHBhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit (ENSG00000138029), score: 0.57 HAND1heart and neural crest derivatives expressed 1 (ENSG00000113196), score: 0.63 HEG1HEG homolog 1 (zebrafish) (ENSG00000173706), score: 0.63 HIPK3homeodomain interacting protein kinase 3 (ENSG00000110422), score: 0.63 HMCN1hemicentin 1 (ENSG00000143341), score: 0.61 HRChistidine rich calcium binding protein (ENSG00000130528), score: 0.56 HSPB3heat shock 27kDa protein 3 (ENSG00000169271), score: 0.59 HSPB7heat shock 27kDa protein family, member 7 (cardiovascular) (ENSG00000173641), score: 0.6 IDH3Bisocitrate dehydrogenase 3 (NAD+) beta (ENSG00000101365), score: 0.57 IDO1indoleamine 2,3-dioxygenase 1 (ENSG00000131203), score: 0.66 IMMTinner membrane protein, mitochondrial (ENSG00000132305), score: 0.57 KANK1KN motif and ankyrin repeat domains 1 (ENSG00000107104), score: 0.55 KBTBD10kelch repeat and BTB (POZ) domain containing 10 (ENSG00000239474), score: 0.63 KBTBD5kelch repeat and BTB (POZ) domain containing 5 (ENSG00000157119), score: 0.55 KCNJ5potassium inwardly-rectifying channel, subfamily J, member 5 (ENSG00000120457), score: 0.63 KIAA0232KIAA0232 (ENSG00000170871), score: 0.62 KIF13Akinesin family member 13A (ENSG00000137177), score: 0.7 KLHDC8Bkelch domain containing 8B (ENSG00000185909), score: 0.67 KLHL24kelch-like 24 (Drosophila) (ENSG00000114796), score: 0.68 KLHL31kelch-like 31 (Drosophila) (ENSG00000124743), score: 0.65 KLHL38kelch-like 38 (Drosophila) (ENSG00000175946), score: 0.69 KLHL7kelch-like 7 (Drosophila) (ENSG00000122550), score: 0.57 KTN1kinectin 1 (kinesin receptor) (ENSG00000126777), score: 0.57 LAMA4laminin, alpha 4 (ENSG00000112769), score: 0.56 LAPTM4Blysosomal protein transmembrane 4 beta (ENSG00000104341), score: 0.56 LDB3LIM domain binding 3 (ENSG00000122367), score: 0.57 LMOD2leiomodin 2 (cardiac) (ENSG00000170807), score: 0.66 LOC100291671similar to SH3-binding domain and glutamic acid-rich protein (ENSG00000185437), score: 0.55 LPAR3lysophosphatidic acid receptor 3 (ENSG00000171517), score: 0.79 LRRC10leucine rich repeat containing 10 (ENSG00000198812), score: 0.64 LRRC14Bleucine rich repeat containing 14B (ENSG00000185028), score: 0.65 LRRC2leucine rich repeat containing 2 (ENSG00000163827), score: 0.61 LRRC39leucine rich repeat containing 39 (ENSG00000122477), score: 0.63 LSM1LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) (ENSG00000175324), score: 0.58 MAPKAPK2mitogen-activated protein kinase-activated protein kinase 2 (ENSG00000162889), score: 0.6 MAPKAPK3mitogen-activated protein kinase-activated protein kinase 3 (ENSG00000114738), score: 0.61 MBmyoglobin (ENSG00000198125), score: 0.59 MEF2Amyocyte enhancer factor 2A (ENSG00000068305), score: 0.57 MEOX2mesenchyme homeobox 2 (ENSG00000106511), score: 0.62 METTL11Bmethyltransferase like 11B (ENSG00000203740), score: 0.83 MFN1mitofusin 1 (ENSG00000171109), score: 0.68 MFN2mitofusin 2 (ENSG00000116688), score: 0.69 MSRB3methionine sulfoxide reductase B3 (ENSG00000174099), score: 0.55 MYBPC3myosin binding protein C, cardiac (ENSG00000134571), score: 0.57 MYH7myosin, heavy chain 7, cardiac muscle, beta (ENSG00000092054), score: 0.56 MYL2myosin, light chain 2, regulatory, cardiac, slow (ENSG00000111245), score: 0.55 MYL3myosin, light chain 3, alkali; ventricular, skeletal, slow (ENSG00000160808), score: 0.58 MYLK3myosin light chain kinase 3 (ENSG00000140795), score: 0.64 MYLK4myosin light chain kinase family, member 4 (ENSG00000145949), score: 0.73 MYO18Bmyosin XVIIIB (ENSG00000133454), score: 0.56 MYOCDmyocardin (ENSG00000141052), score: 0.69 MYOTmyotilin (ENSG00000120729), score: 0.56 MYOZ2myozenin 2 (ENSG00000172399), score: 0.66 MYPNmyopalladin (ENSG00000138347), score: 0.62 NDUFA12NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 (ENSG00000184752), score: 0.66 NDUFA8NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa (ENSG00000119421), score: 0.55 NDUFA9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa (ENSG00000139180), score: 0.57 NDUFS1NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) (ENSG00000023228), score: 0.6 NFU1NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae) (ENSG00000169599), score: 0.61 NHLRC2NHL repeat containing 2 (ENSG00000196865), score: 0.68 NKX2-5NK2 transcription factor related, locus 5 (Drosophila) (ENSG00000183072), score: 0.58 NNTnicotinamide nucleotide transhydrogenase (ENSG00000112992), score: 0.64 NOX3NADPH oxidase 3 (ENSG00000074771), score: 0.65 NR2F1nuclear receptor subfamily 2, group F, member 1 (ENSG00000175745), score: -0.59 NUBPLnucleotide binding protein-like (ENSG00000151413), score: 0.58 OPA1optic atrophy 1 (autosomal dominant) (ENSG00000198836), score: 0.55 OR5K1olfactory receptor, family 5, subfamily K, member 1 (ENSG00000232382), score: 1 P2RX1purinergic receptor P2X, ligand-gated ion channel, 1 (ENSG00000108405), score: 0.55 PBX3pre-B-cell leukemia homeobox 3 (ENSG00000167081), score: 0.65 PCpyruvate carboxylase (ENSG00000173599), score: -0.59 PCBD2pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 (ENSG00000132570), score: 0.6 PDE3Aphosphodiesterase 3A, cGMP-inhibited (ENSG00000172572), score: 0.63 PDHXpyruvate dehydrogenase complex, component X (ENSG00000110435), score: 0.6 PEX6peroxisomal biogenesis factor 6 (ENSG00000124587), score: -0.58 PHACTR2phosphatase and actin regulator 2 (ENSG00000112419), score: 0.65 PHGDHphosphoglycerate dehydrogenase (ENSG00000092621), score: -0.61 PHKA1phosphorylase kinase, alpha 1 (muscle) (ENSG00000067177), score: 0.56 PHKBphosphorylase kinase, beta (ENSG00000102893), score: 0.72 PIGFphosphatidylinositol glycan anchor biosynthesis, class F (ENSG00000151665), score: 0.77 PIH1D1PIH1 domain containing 1 (ENSG00000104872), score: -0.64 PKP2plakophilin 2 (ENSG00000057294), score: 0.6 PLNphospholamban (ENSG00000198523), score: 0.68 POF1Bpremature ovarian failure, 1B (ENSG00000124429), score: 0.96 POPDC2popeye domain containing 2 (ENSG00000121577), score: 0.59 POSTNperiostin, osteoblast specific factor (ENSG00000133110), score: 0.57 PPIP5K2diphosphoinositol pentakisphosphate kinase 2 (ENSG00000145725), score: 0.59 PPP1R12Bprotein phosphatase 1, regulatory (inhibitor) subunit 12B (ENSG00000077157), score: 0.64 PPP1R3Aprotein phosphatase 1, regulatory (inhibitor) subunit 3A (ENSG00000154415), score: 0.75 PPTC7PTC7 protein phosphatase homolog (S. cerevisiae) (ENSG00000196850), score: 0.63 PRKAA2protein kinase, AMP-activated, alpha 2 catalytic subunit (ENSG00000162409), score: 0.59 PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunit (ENSG00000106617), score: 0.55 PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) (ENSG00000108946), score: 0.62 PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 2 (ENSG00000161057), score: 0.59 PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 (ENSG00000173692), score: 0.59 PTDSS1phosphatidylserine synthase 1 (ENSG00000156471), score: 0.72 PTP4A3protein tyrosine phosphatase type IVA, member 3 (ENSG00000184489), score: 0.67 PTPRFprotein tyrosine phosphatase, receptor type, F (ENSG00000142949), score: -0.58 PYGO2pygopus homolog 2 (Drosophila) (ENSG00000163348), score: -0.67 QRFPRpyroglutamylated RFamide peptide receptor (ENSG00000186867), score: 0.86 RAB11FIP1RAB11 family interacting protein 1 (class I) (ENSG00000156675), score: 0.6 RAP1ARAP1A, member of RAS oncogene family (ENSG00000116473), score: 0.6 RBM20RNA binding motif protein 20 (ENSG00000203867), score: 0.63 RBM23RNA binding motif protein 23 (ENSG00000100461), score: -0.6 RBM24RNA binding motif protein 24 (ENSG00000112183), score: 0.61 RCAN1regulator of calcineurin 1 (ENSG00000159200), score: 0.6 RCE1RCE1 homolog, prenyl protein peptidase (S. cerevisiae) (ENSG00000173653), score: -0.61 RECQLRecQ protein-like (DNA helicase Q1-like) (ENSG00000004700), score: 0.61 RGS9BPregulator of G protein signaling 9 binding protein (ENSG00000186326), score: 0.64 RHOT1ras homolog gene family, member T1 (ENSG00000126858), score: 0.57 RNF115ring finger protein 115 (ENSG00000121848), score: 0.74 RNF180ring finger protein 180 (ENSG00000164197), score: 0.58 RYR2ryanodine receptor 2 (cardiac) (ENSG00000198626), score: 0.59 SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein) (ENSG00000170624), score: 0.61 SGCGsarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) (ENSG00000102683), score: 0.58 SIAEsialic acid acetylesterase (ENSG00000110013), score: 0.6 SIRT5sirtuin 5 (ENSG00000124523), score: 0.58 SLC25A30solute carrier family 25, member 30 (ENSG00000174032), score: 0.61 SLC25A4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 (ENSG00000151729), score: 0.55 SLC26A9solute carrier family 26, member 9 (ENSG00000174502), score: 0.59 SLC27A6solute carrier family 27 (fatty acid transporter), member 6 (ENSG00000113396), score: 0.83 SLC2A4solute carrier family 2 (facilitated glucose transporter), member 4 (ENSG00000181856), score: 0.57 SLC5A1solute carrier family 5 (sodium/glucose cotransporter), member 1 (ENSG00000100170), score: 0.69 SLC8A1solute carrier family 8 (sodium/calcium exchanger), member 1 (ENSG00000183023), score: 0.57 SMC2structural maintenance of chromosomes 2 (ENSG00000136824), score: 0.57 SMPXsmall muscle protein, X-linked (ENSG00000091482), score: 0.61 SMYD1SET and MYND domain containing 1 (ENSG00000115593), score: 0.56 SMYD2SET and MYND domain containing 2 (ENSG00000143499), score: 0.64 SNX6sorting nexin 6 (ENSG00000129515), score: 0.6 SPAG7sperm associated antigen 7 (ENSG00000091640), score: 0.55 SPC24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) (ENSG00000161888), score: 0.61 SRLsarcalumenin (ENSG00000185739), score: 0.6 ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (ENSG00000140557), score: 0.9 STK38Lserine/threonine kinase 38 like (ENSG00000211455), score: 0.62 STRNstriatin, calmodulin binding protein (ENSG00000115808), score: 0.63 STRN3striatin, calmodulin binding protein 3 (ENSG00000196792), score: 0.59 SYNPO2Lsynaptopodin 2-like (ENSG00000166317), score: 0.66 TAX1BP1Tax1 (human T-cell leukemia virus type I) binding protein 1 (ENSG00000106052), score: 0.61 TBX20T-box 20 (ENSG00000164532), score: 0.66 TBX5T-box 5 (ENSG00000089225), score: 0.56 TCAPtitin-cap (telethonin) (ENSG00000173991), score: 0.6 TEAD1TEA domain family member 1 (SV40 transcriptional enhancer factor) (ENSG00000187079), score: 0.59 TECRLtrans-2,3-enoyl-CoA reductase-like (ENSG00000205678), score: 0.68 TMEM182transmembrane protein 182 (ENSG00000170417), score: 0.7 TMEM40transmembrane protein 40 (ENSG00000088726), score: 0.81 TNNC1troponin C type 1 (slow) (ENSG00000114854), score: 0.57 TNNI3troponin I type 3 (cardiac) (ENSG00000129991), score: 0.58 TOR2Atorsin family 2, member A (ENSG00000160404), score: -0.68 TRAK2trafficking protein, kinesin binding 2 (ENSG00000115993), score: 0.55 TRDNtriadin (ENSG00000186439), score: 0.62 TRIM63tripartite motif-containing 63 (ENSG00000158022), score: 0.62 TSEN15tRNA splicing endonuclease 15 homolog (S. cerevisiae) (ENSG00000198860), score: 0.58 TXLNBtaxilin beta (ENSG00000164440), score: 0.62 TYRP1tyrosinase-related protein 1 (ENSG00000107165), score: 0.89 UBA3ubiquitin-like modifier activating enzyme 3 (ENSG00000144744), score: 0.77 UBE2Aubiquitin-conjugating enzyme E2A (RAD6 homolog) (ENSG00000077721), score: 0.66 UEVLDUEV and lactate/malate dehyrogenase domains (ENSG00000151116), score: 0.56 UNC45Bunc-45 homolog B (C. elegans) (ENSG00000141161), score: 0.58 UQCRC2ubiquinol-cytochrome c reductase core protein II (ENSG00000140740), score: 0.55 USP28ubiquitin specific peptidase 28 (ENSG00000048028), score: 0.59 VPS33Bvacuolar protein sorting 33 homolog B (yeast) (ENSG00000184056), score: -0.62 WDYHV1WDYHV motif containing 1 (ENSG00000156795), score: 0.63 XIRP1xin actin-binding repeat containing 1 (ENSG00000168334), score: 0.58 YTHDF3YTH domain family, member 3 (ENSG00000185728), score: 0.55 ZAKsterile alpha motif and leucine zipper containing kinase AZK (ENSG00000091436), score: 0.67 ZBTB43zinc finger and BTB domain containing 43 (ENSG00000169155), score: 0.57 ZNF330zinc finger protein 330 (ENSG00000109445), score: 0.62 ZSCAN21zinc finger and SCAN domain containing 21 (ENSG00000166529), score: -0.59
| Id | species | tissue | sex | individual |
|---|---|---|---|---|
| ptr_ht_f_ca1 | ptr | ht | f | _ |
| ppa_ht_f_ca1 | ppa | ht | f | _ |
| ptr_ht_m_ca1 | ptr | ht | m | _ |
