Under-expression is coded with green,
over-expression with red color.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
adaptive immune response
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).
immune effector process
Any process of the immune system that occurs as part of an immune response.
activation of immune response
Any process that initiates an immune response.
immune system process
Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
leukocyte mediated immunity
Any process involved in the carrying out of an immune response by a leukocyte.
lymphocyte mediated immunity
Any process involved in the carrying out of an immune response by a lymphocyte.
humoral immune response mediated by circulating immunoglobulin
An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.
acute inflammatory response
Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
activation of plasma proteins involved in acute inflammatory response
Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
regulation of immune system process
Any process that modulates the frequency, rate, or extent of an immune system process.
positive regulation of immune system process
Any process that activates or increases the frequency, rate, or extent of an immune system process.
defense response
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
organic acid metabolic process
The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
protein maturation by peptide bond cleavage
The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
lipid metabolic process
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
steroid biosynthetic process
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
bile acid biosynthetic process
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
steroid catabolic process
The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
cellular ion homeostasis
Any process involved in the maintenance of an internal steady-state of ions at the level of a cell.
cellular zinc ion homeostasis
Any process involved in the maintenance of an internal steady-state of zinc ions at the level of a cell.
response to stress
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
inflammatory response
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
immune response
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
complement activation, alternative pathway
Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
humoral immune response
An immune response mediated through a body fluid.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
steroid metabolic process
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
bile acid metabolic process
The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
lipid biosynthetic process
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
biosynthetic process
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
cellular amino acid catabolic process
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
amine catabolic process
The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
response to wounding
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
gene expression
The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
lipid catabolic process
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
organic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
immunoglobulin mediated immune response
An immune response mediated by immunoglobulins, whether cell-bound or in solution.
protein processing
Any protein maturation process achieved by the cleavage of peptide bonds.
protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
B cell mediated immunity
Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
cellular homeostasis
Any process involved in the maintenance of an internal steady-state at the level of the cell.
carboxylic acid metabolic process
The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
cellular cation homeostasis
Any process involved in the maintenance of an internal steady-state of cations at the level of a cell.
cellular di-, tri-valent inorganic cation homeostasis
Any process involved in the maintenance of an internal steady-state of divalent or trivalent cations at the level of a cell.
bile acid catabolic process
The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.
monocarboxylic acid metabolic process
The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
cellular ketone metabolic process
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
homeostatic process
Any biological process involved in the maintenance of an internal steady-state.
macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
oxoacid metabolic process
The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
cellular amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
small molecule metabolic process
The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
small molecule biosynthetic process
The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.
innate immune response
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
carboxylic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
carboxylic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
ion homeostasis
Any process involved in the maintenance of an internal steady-state of ions within an organism or cell.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of response to stimulus
Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
chemical homeostasis
Any biological process involved in the maintenance of an internal steady-state of a chemical.
regulation of immune response
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
response to stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
protein maturation
Any process leading to the attainment of the full functional capacity of a protein.
di-, tri-valent inorganic cation homeostasis
Any process involved in the maintenance of an internal steady-state of divalent or trivalent cations within an organism or cell.
zinc ion homeostasis
Any process involved in the maintenance of an internal steady-state of zinc ions within an organism or cell.
cation homeostasis
Any process involved in the maintenance of an internal steady-state of cations within an organism or cell.
cellular chemical homeostasis
Any biological process involved in the maintenance of an internal steady-state of a chemical at the level of the cell.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
regulation of biological quality
Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
all
NA
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
positive regulation of immune system process
Any process that activates or increases the frequency, rate, or extent of an immune system process.
regulation of immune system process
Any process that modulates the frequency, rate, or extent of an immune system process.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
immune response
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
regulation of response to stimulus
Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
organic acid metabolic process
The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
cellular ketone metabolic process
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
small molecule biosynthetic process
The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
positive regulation of immune system process
Any process that activates or increases the frequency, rate, or extent of an immune system process.
immune effector process
Any process of the immune system that occurs as part of an immune response.
regulation of immune response
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
regulation of immune response
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
cellular amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
organic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
protein maturation
Any process leading to the attainment of the full functional capacity of a protein.
organic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
oxoacid metabolic process
The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
lipid biosynthetic process
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
lipid catabolic process
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
activation of immune response
Any process that initiates an immune response.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
complement activation, alternative pathway
Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
innate immune response
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
inflammatory response
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
cellular homeostasis
Any process involved in the maintenance of an internal steady-state at the level of the cell.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
cellular amino acid catabolic process
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
steroid biosynthetic process
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
steroid catabolic process
The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
B cell mediated immunity
Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
cellular chemical homeostasis
Any biological process involved in the maintenance of an internal steady-state of a chemical at the level of the cell.
cellular amino acid catabolic process
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
bile acid catabolic process
The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.
bile acid biosynthetic process
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
carboxylic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
carboxylic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
bile acid biosynthetic process
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
bile acid catabolic process
The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.
cellular ion homeostasis
Any process involved in the maintenance of an internal steady-state of ions at the level of a cell.
activation of plasma proteins involved in acute inflammatory response
Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
bile acid metabolic process
The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
humoral immune response mediated by circulating immunoglobulin
An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
cellular cation homeostasis
Any process involved in the maintenance of an internal steady-state of cations at the level of a cell.
cellular di-, tri-valent inorganic cation homeostasis
Any process involved in the maintenance of an internal steady-state of divalent or trivalent cations at the level of a cell.
cellular zinc ion homeostasis
Any process involved in the maintenance of an internal steady-state of zinc ions at the level of a cell.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
extracellular space
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
all
NA
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
catalytic activity
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
monooxygenase activity
Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
oxidoreductase activity
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
steroid hydroxylase activity
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
oxysterol 7-alpha-hydroxylase activity
Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
all
NA
oxysterol 7-alpha-hydroxylase activity
Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O.
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 00120 | 1.912e-04 | 0.03438 | 3 | 3 | Primary bile acid biosynthesis |
| 04610 | 4.659e-03 | 0.2407 | 4 | 21 | Complement and coagulation cascades |
| 00140 | 4.353e-02 | 0.0573 | 2 | 5 | Steroid hormone biosynthesis |
ABCA1ATP-binding cassette, sub-family A (ABC1), member 1 (ENSG00000165029), score: 0.74 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.78 ALBalbumin (ENSG00000163631), score: 0.75 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.77 ARL14ADP-ribosylation factor-like 14 (ENSG00000179674), score: 0.77 C5complement component 5 (ENSG00000106804), score: 0.74 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.75 CA6carbonic anhydrase VI (ENSG00000131686), score: 1 CEPT1choline/ethanolamine phosphotransferase 1 (ENSG00000134255), score: 0.83 CLDN1claudin 1 (ENSG00000163347), score: 0.76 CTBSchitobiase, di-N-acetyl- (ENSG00000117151), score: 0.76 CUEDC2CUE domain containing 2 (ENSG00000107874), score: -0.86 CYP39A1cytochrome P450, family 39, subfamily A, polypeptide 1 (ENSG00000146233), score: 1 CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1 (ENSG00000172817), score: 0.75 F9coagulation factor IX (ENSG00000101981), score: 0.86 FETUBfetuin B (ENSG00000090512), score: 0.95 GAS6growth arrest-specific 6 (ENSG00000183087), score: -0.87 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.93 HPXhemopexin (ENSG00000110169), score: 0.75 IL22RA2interleukin 22 receptor, alpha 2 (ENSG00000164485), score: 0.83 IYDiodotyrosine deiodinase (ENSG00000009765), score: 0.82 LOC100292021similar to thioredoxin peroxidase (ENSG00000123131), score: 0.75 LRRC15leucine rich repeat containing 15 (ENSG00000172061), score: 0.75 LY75lymphocyte antigen 75 (ENSG00000054219), score: 0.76 MAT1Amethionine adenosyltransferase I, alpha (ENSG00000151224), score: 0.74 MKLN1muskelin 1, intracellular mediator containing kelch motifs (ENSG00000128585), score: 0.78 MTTPmicrosomal triglyceride transfer protein (ENSG00000138823), score: 0.74 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.75 PPEF2protein phosphatase, EF-hand calcium binding domain 2 (ENSG00000156194), score: 0.75 RGS18regulator of G-protein signaling 18 (ENSG00000150681), score: 0.85 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.73 SLC2A9solute carrier family 2 (facilitated glucose transporter), member 9 (ENSG00000109667), score: 0.78 SLC30A1solute carrier family 30 (zinc transporter), member 1 (ENSG00000170385), score: 0.78 SLC30A7solute carrier family 30 (zinc transporter), member 7 (ENSG00000162695), score: 0.76 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.81 SPP2secreted phosphoprotein 2, 24kDa (ENSG00000072080), score: 0.9 TATtyrosine aminotransferase (ENSG00000198650), score: 0.77 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.76 TMEM135transmembrane protein 135 (ENSG00000166575), score: 0.79 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.84 TWSG1twisted gastrulation homolog 1 (Drosophila) (ENSG00000128791), score: -0.88 USO1USO1 vesicle docking protein homolog (yeast) (ENSG00000138768), score: 0.82 VSIG4V-set and immunoglobulin domain containing 4 (ENSG00000155659), score: 0.76 WDFY2WD repeat and FYVE domain containing 2 (ENSG00000139668), score: 0.87 XCR1chemokine (C motif) receptor 1 (ENSG00000173578), score: 0.77 XKR9XK, Kell blood group complex subunit-related family, member 9 (ENSG00000221947), score: 0.75
| Id | species | tissue | sex | individual |
|---|---|---|---|---|
| gga_lv_f_ca1 | gga | lv | f | _ |
| gga_lv_m_ca1 | gga | lv | m | _ |
| oan_lv_m_ca1 | oan | lv | m | _ |
| oan_lv_f_ca1 | oan | lv | f | _ |
| mdo_lv_m_ca1 | mdo | lv | m | _ |
| mdo_lv_f_ca1 | mdo | lv | f | _ |
