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system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

neurological system process

A organ system process carried out by any of the organs or tissues of neurological system.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

sensory perception

The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.

sensory perception of chemical stimulus

The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.

sensory perception of taste

The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

all

NA

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

brush border

Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

cation channel complex

An ion channel complex through which cations pass.

sodium channel complex

An ion channel complex through which sodium ions pass.

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

sodium channel activity

Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

secondary active transmembrane transporter activity

Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

amiloride-sensitive sodium channel activity

NA

symporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

protein domain specific binding

Interacting selectively and non-covalently with a specific domain of a protein.

passive transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.

active transmembrane transporter activity

Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.

ligand-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

inorganic cation transmembrane transporter activity

Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

WW domain binding

Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

amiloride-sensitive sodium channel activity

NA

Id	Pvalue	ExpCount	Count	Size	Term
GO:0007588	2.767e-08	0.3695	9 AQP3, ATP6V0A4, CLCN5, CLDN16, DAB2, KCNJ1, SCNN1A, SCNN1B, SCNN1G	24	excretion
GO:0006811	2.527e-04	5.111	18 ATP6V0A4, CLCN5, CLDN16, CLIC6, CNNM2, KCNJ1, KCNJ16, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC34A1, SLC5A12, SLC5A9, TRPM6, WNK1	332	ion transport
GO:0006814	7.889e-04	0.7236	7 SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC34A1, SLC5A12, SLC5A9	47	sodium ion transport
GO:0015672	8.384e-04	1.724	10 ATP6V0A4, KCNJ1, KCNJ16, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC34A1, SLC5A12, SLC5A9	112	monovalent inorganic cation transport
GO:0006812	3.213e-03	3.51	13 ATP6V0A4, KCNJ1, KCNJ16, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC34A1, SLC5A12, SLC5A9, TRPM6	228	cation transport
GO:0050909	5.740e-03	0.09237	3 SCNN1A, SCNN1B, SCNN1G	6	sensory perception of taste
GO:0046903	9.984e-03	2.956	11 AGR2, AQP3, ATP6V0A4, CLCN5, CLDN16, DAB2, FAM3D, KCNJ1, SCNN1A, SCNN1B, SCNN1G	192	secretion
GO:0048704	1.371e-02	0.3079	4 GSC, HOXB7, HOXD10, HOXD4	20	embryonic skeletal system morphogenesis
GO:0051234	1.773e-02	16.67	30 AGR2, AQP3, ATP6V0A4, CLCN5, CLDN16, CLIC6, CNNM2, CUBN, DAB2, DPP4, FAM3D, KCNJ1, KCNJ16, RAB19, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC16A12, SLC16A4, SLC19A1, SLC25A48, SLC34A1, SLC5A12, SLC5A9, SLC6A19, TRPM6, WNK1	1083	establishment of localization
GO:0006810	3.005e-02	16.49	29 AGR2, AQP3, ATP6V0A4, CLCN5, CLDN16, CLIC6, CNNM2, CUBN, DAB2, FAM3D, KCNJ1, KCNJ16, RAB19, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC16A12, SLC16A4, SLC19A1, SLC25A48, SLC34A1, SLC5A12, SLC5A9, SLC6A19, TRPM6, WNK1	1071	transport
GO:0015696	3.388e-02	0.04619	2 RHAG, RHCG	3	ammonium transport
GO:0035313	3.388e-02	0.04619	2 SCNN1B, SCNN1G	3	wound healing, spreading of epidermal cells
GO:0044319	3.388e-02	0.04619	2 SCNN1B, SCNN1G	3	wound healing, spreading of cells
GO:0030001	3.801e-02	3.064	10 KCNJ1, KCNJ16, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC34A1, SLC5A12, SLC5A9, TRPM6	199	metal ion transport
GO:0007606	4.076e-02	0.2001	3 SCNN1A, SCNN1B, SCNN1G	13	sensory perception of chemical stimulus
GO:0048562	4.460e-02	0.7851	5 FOXI1, GSC, HOXB7, HOXD10, HOXD4	51	embryonic organ morphogenesis
GO:0048706	4.547e-02	0.4619	4 GSC, HOXB7, HOXD10, HOXD4	30	embryonic skeletal system development

Id	Pvalue	ExpCount	Count	Size	Term
GO:0045177	7.689e-08	1.099	12 ATP6V0A4, CLCN5, CUBN, DPP4, LGMN, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC5A12, TRPM6	75	apical part of cell
GO:0016324	9.349e-07	0.8643	10 ATP6V0A4, CUBN, DPP4, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC5A12, TRPM6	59	apical plasma membrane
GO:0034706	1.478e-04	0.04395	3 SCNN1A, SCNN1B, SCNN1G	3	sodium channel complex
GO:0005886	2.256e-04	16.6	34 ANKS4B, APLP2, AQP3, ATP6V0A4, CASR, CLCN5, CLDN16, CLDN19, CLIC6, CUBN, DPP4, EREG, FERMT1, FRAS1, KCNJ1, KCNJ16, LYPD2, RAB19, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC16A12, SLC16A4, SLC19A1, SLC34A1, SLC5A12, SLC5A9, SLC6A19, ST14, TRPM6, XPNPEP2	1133	plasma membrane
GO:0044459	5.875e-04	10.56	25 AQP3, ATP6V0A4, CASR, CLCN5, CLDN16, CLDN19, CUBN, DPP4, EREG, FERMT1, KCNJ1, KCNJ16, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC16A4, SLC19A1, SLC34A1, SLC5A12, SLC6A19, ST14, TRPM6	721	plasma membrane part
GO:0031526	9.540e-04	0.1904	4 ATP6V0A4, CUBN, SLC34A1, TRPM6	13	brush border membrane
GO:0031253	1.081e-03	0.6299	6 ATP6V0A4, CUBN, DPP4, FERMT1, SLC34A1, TRPM6	43	cell projection membrane
GO:0031224	1.737e-03	23.69	40 APLP2, AQP3, ATP6V0A4, CASR, CLCN5, CLDN16, CLDN19, CLIC6, CNNM2, DPP4, EREG, FRAS1, GALNT14, KCNJ1, KCNJ16, LYPD2, MARVELD3, PTPRQ, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SHISA2, SLC10A2, SLC16A12, SLC16A4, SLC19A1, SLC25A48, SLC34A1, SLC5A12, SLC5A9, SLC6A19, ST14, SUSD2, TMEM171, TMEM27, TMPRSS13, TRPM6, XPNPEP2	1617	intrinsic to membrane
GO:0005903	3.052e-03	0.2637	4 ATP6V0A4, CUBN, SLC34A1, TRPM6	18	brush border
GO:0044425	5.252e-03	27.82	43 APLP2, AQP3, ATP6V0A4, CASR, CLCN5, CLDN16, CLDN19, CLIC6, CNNM2, CUBN, DAB2, DPP4, EREG, FERMT1, FRAS1, GALNT14, KCNJ1, KCNJ16, LYPD2, MARVELD3, PTPRQ, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SHISA2, SLC10A2, SLC16A12, SLC16A4, SLC19A1, SLC25A48, SLC34A1, SLC5A12, SLC5A9, SLC6A19, ST14, SUSD2, TMEM171, TMEM27, TMPRSS13, TRPM6, XPNPEP2	1899	membrane part
GO:0016021	5.418e-03	23.2	38 APLP2, AQP3, ATP6V0A4, CASR, CLCN5, CLDN16, CLDN19, CLIC6, CNNM2, DPP4, EREG, FRAS1, GALNT14, KCNJ1, KCNJ16, MARVELD3, PTPRQ, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SHISA2, SLC10A2, SLC16A12, SLC16A4, SLC19A1, SLC25A48, SLC34A1, SLC5A12, SLC5A9, SLC6A19, ST14, SUSD2, TMEM171, TMEM27, TMPRSS13, TRPM6	1584	integral to membrane
GO:0005887	3.432e-02	6.05	14 CASR, CLCN5, EREG, KCNJ1, KCNJ16, RHAG, RHCG, SCNN1G, SLC10A2, SLC16A4, SLC19A1, SLC34A1, SLC6A19, ST14	413	integral to plasma membrane
GO:0031226	4.076e-02	6.197	14 CASR, CLCN5, EREG, KCNJ1, KCNJ16, RHAG, RHCG, SCNN1G, SLC10A2, SLC16A4, SLC19A1, SLC34A1, SLC6A19, ST14	423	intrinsic to plasma membrane
GO:0034703	4.253e-02	0.9961	5 KCNJ1, KCNJ16, SCNN1A, SCNN1B, SCNN1G	68	cation channel complex
GO:0016020	4.554e-02	34.09	46 ANKS4B, APLP2, AQP3, ATP6V0A4, CASR, CLCN5, CLDN16, CLDN19, CLIC6, CNNM2, CUBN, DAB2, DPP4, EREG, FERMT1, FRAS1, GALNT14, KCNJ1, KCNJ16, LYPD2, MARVELD3, PTPRQ, RAB19, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SHISA2, SLC10A2, SLC16A12, SLC16A4, SLC19A1, SLC25A48, SLC34A1, SLC5A12, SLC5A9, SLC6A19, ST14, SUSD2, TFCP2L1, TMEM171, TMEM27, TMPRSS13, TRPM6, XPNPEP2	2327	membrane

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022857	2.003e-05	5.612	21 AQP3, ATP6V0A4, CLCN5, CLDN16, CLIC6, KCNJ1, KCNJ16, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC16A12, SLC16A4, SLC19A1, SLC34A1, SLC5A12, SLC5A9, SLC6A19, TRPM6	368	transmembrane transporter activity
GO:0005215	3.188e-05	6.924	23 AQP3, ATP6V0A4, CLCN5, CLDN16, CLIC6, CUBN, KCNJ1, KCNJ16, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC16A12, SLC16A4, SLC19A1, SLC25A48, SLC34A1, SLC5A12, SLC5A9, SLC6A19, TRPM6	454	transporter activity
GO:0022891	3.328e-04	5.216	18 AQP3, ATP6V0A4, CLCN5, CLDN16, CLIC6, KCNJ1, KCNJ16, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC16A4, SLC34A1, SLC5A9, SLC6A19, TRPM6	342	substrate-specific transmembrane transporter activity
GO:0015291	5.395e-04	1.281	9 CLCN5, SLC10A2, SLC16A12, SLC16A4, SLC19A1, SLC34A1, SLC5A12, SLC5A9, SLC6A19	84	secondary active transmembrane transporter activity
GO:0015075	8.852e-04	4.575	16 ATP6V0A4, CLCN5, CLDN16, CLIC6, KCNJ1, KCNJ16, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC34A1, SLC5A9, SLC6A19, TRPM6	300	ion transmembrane transporter activity
GO:0022892	1.357e-03	5.917	18 AQP3, ATP6V0A4, CLCN5, CLDN16, CLIC6, KCNJ1, KCNJ16, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC16A4, SLC34A1, SLC5A9, SLC6A19, TRPM6	388	substrate-specific transporter activity
GO:0015280	1.405e-03	0.061	3 SCNN1A, SCNN1B, SCNN1G	4	amiloride-sensitive sodium channel activity
GO:0015293	1.791e-03	0.8541	7 SLC10A2, SLC16A12, SLC16A4, SLC34A1, SLC5A12, SLC5A9, SLC6A19	56	symporter activity
GO:0022804	2.105e-03	1.983	10 ATP6V0A4, CLCN5, SLC10A2, SLC16A12, SLC16A4, SLC19A1, SLC34A1, SLC5A12, SLC5A9, SLC6A19	130	active transmembrane transporter activity
GO:0008324	2.570e-03	3.462	13 ATP6V0A4, CLDN16, KCNJ1, KCNJ16, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC5A9, SLC6A19, TRPM6	227	cation transmembrane transporter activity
GO:0050699	4.779e-03	0.09151	3 SCNN1A, SCNN1B, SCNN1G	6	WW domain binding
GO:0022890	8.869e-03	1.174	7 ATP6V0A4, CLDN16, RHAG, RHCG, SLC10A2, SLC5A9, SLC6A19	77	inorganic cation transmembrane transporter activity
GO:0008519	1.244e-02	0.0305	2 RHAG, RHCG	2	ammonium transmembrane transporter activity
GO:0003700	1.731e-02	4.423	13 EHF, FOXI1, GATA3, GRHL2, GSC, HNF4G, HOXA10, HOXB7, HOXD10, HOXD4, SIM1, TFAP2B, TFCP2L1	290	sequence-specific DNA binding transcription factor activity
GO:0005272	2.265e-02	0.1678	3 SCNN1A, SCNN1B, SCNN1G	11	sodium channel activity
GO:0030506	2.807e-02	0.04575	2 RHAG, RHCG	3	ankyrin binding
GO:0051739	2.807e-02	0.04575	2 RHAG, RHCG	3	ammonia transmembrane transporter activity
GO:0043565	3.263e-02	3.065	10 EHF, FOXI1, GATA3, GSC, HNF4G, HOXA10, HOXB7, HOXD10, HOXD4, TFAP2B	201	sequence-specific DNA binding
GO:0015101	4.549e-02	0.061	2 RHAG, RHCG	4	organic cation transmembrane transporter activity
GO:0022838	4.877e-02	2.745	9 AQP3, CLCN5, CLIC6, KCNJ1, KCNJ16, SCNN1A, SCNN1B, SCNN1G, TRPM6	180	substrate-specific channel activity

Id	Pvalue	ExpCount	Count	Size	Term
04960	7.680e-05	0.1834	5 HSD11B2, KCNJ1, SCNN1A, SCNN1B, SCNN1G	16	Aldosterone-regulated sodium reabsorption
04742	8.980e-03	0.1146	3 SCNN1A, SCNN1B, SCNN1G	10	Taste transduction

No enriched terms

No enriched terms

Entrez genes

AGR2anterior gradient homolog 2 (Xenopus laevis) (ENSG00000106541), score: 0.7 ANKS4Bankyrin repeat and sterile alpha motif domain containing 4B (ENSG00000175311), score: 0.62 APLP2amyloid beta (A4) precursor-like protein 2 (ENSG00000084234), score: 0.65 AQP3aquaporin 3 (Gill blood group) (ENSG00000165272), score: 0.61 ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 1 (ENSG00000104763), score: 0.63 ASPAaspartoacylase (ENSG00000108381), score: 0.61 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.75 BMP3bone morphogenetic protein 3 (ENSG00000152785), score: 0.62 C1orf116chromosome 1 open reading frame 116 (ENSG00000182795), score: 0.69 CASRcalcium-sensing receptor (ENSG00000036828), score: 0.76 CLCN5chloride channel 5 (ENSG00000171365), score: 0.64 CLDN16claudin 16 (ENSG00000113946), score: 0.7 CLDN19claudin 19 (ENSG00000164007), score: 0.87 CLIC6chloride intracellular channel 6 (ENSG00000159212), score: 1 CNNM2cyclin M2 (ENSG00000148842), score: 0.66 COL4A4collagen, type IV, alpha 4 (ENSG00000081052), score: 0.72 CUBNcubilin (intrinsic factor-cobalamin receptor) (ENSG00000107611), score: 0.8 DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (ENSG00000153071), score: 0.67 DHDPSLdihydrodipicolinate synthase-like, mitochondrial (ENSG00000241935), score: 0.62 DPP4dipeptidyl-peptidase 4 (ENSG00000197635), score: 0.62 EHFets homologous factor (ENSG00000135373), score: 0.69 EREGepiregulin (ENSG00000124882), score: 0.8 FAM3Dfamily with sequence similarity 3, member D (ENSG00000198643), score: 0.76 FERMT1fermitin family member 1 (ENSG00000101311), score: 0.68 FOXI1forkhead box I1 (ENSG00000168269), score: 0.69 FRAS1Fraser syndrome 1 (ENSG00000138759), score: 0.68 FSHBfollicle stimulating hormone, beta polypeptide (ENSG00000131808), score: 0.67 GALNT14UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) (ENSG00000158089), score: 0.61 GATA3GATA binding protein 3 (ENSG00000107485), score: 0.74 GRHL2grainyhead-like 2 (Drosophila) (ENSG00000083307), score: 0.72 GSCgoosecoid homeobox (ENSG00000133937), score: 0.95 HNF4Ghepatocyte nuclear factor 4, gamma (ENSG00000164749), score: 0.65 HOXA10homeobox A10 (ENSG00000153807), score: 0.66 HOXB7homeobox B7 (ENSG00000120087), score: 0.69 HOXD10homeobox D10 (ENSG00000128710), score: 0.88 HOXD4homeobox D4 (ENSG00000170166), score: 0.72 HSD11B2hydroxysteroid (11-beta) dehydrogenase 2 (ENSG00000176387), score: 0.7 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.65 KCNJ16potassium inwardly-rectifying channel, subfamily J, member 16 (ENSG00000153822), score: 0.66 KLHL14kelch-like 14 (Drosophila) (ENSG00000197705), score: 0.7 LGALS2lectin, galactoside-binding, soluble, 2 (ENSG00000100079), score: 0.66 LGMNlegumain (ENSG00000100600), score: 0.71 LRRC58leucine rich repeat containing 58 (ENSG00000163428), score: 0.64 LYPD2LY6/PLAUR domain containing 2 (ENSG00000197353), score: 0.68 MARVELD3MARVEL domain containing 3 (ENSG00000140832), score: 0.65 PTPRQprotein tyrosine phosphatase, receptor type, Q (ENSG00000139304), score: 0.74 PYROXD2pyridine nucleotide-disulphide oxidoreductase domain 2 (ENSG00000119943), score: 0.75 RAB19RAB19, member RAS oncogene family (ENSG00000146955), score: 0.81 RASSF6Ras association (RalGDS/AF-6) domain family member 6 (ENSG00000169435), score: 0.65 RHAGRh-associated glycoprotein (ENSG00000112077), score: 0.93 RHCGRh family, C glycoprotein (ENSG00000140519), score: 0.73 SCNN1Asodium channel, nonvoltage-gated 1 alpha (ENSG00000111319), score: 0.63 SCNN1Bsodium channel, nonvoltage-gated 1, beta (ENSG00000168447), score: 0.79 SCNN1Gsodium channel, nonvoltage-gated 1, gamma (ENSG00000166828), score: 0.7 SDSLserine dehydratase-like (ENSG00000139410), score: 0.62 SHISA2shisa homolog 2 (Xenopus laevis) (ENSG00000180730), score: 0.65 SIM1single-minded homolog 1 (Drosophila) (ENSG00000112246), score: 0.91 SLC10A2solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (ENSG00000125255), score: 0.73 SLC16A12solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (ENSG00000152779), score: 0.61 SLC16A4solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (ENSG00000168679), score: 0.74 SLC19A1solute carrier family 19 (folate transporter), member 1 (ENSG00000173638), score: 0.62 SLC25A48solute carrier family 25, member 48 (ENSG00000145832), score: 0.69 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 0.81 SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12 (ENSG00000148942), score: 0.69 SLC5A9solute carrier family 5 (sodium/glucose cotransporter), member 9 (ENSG00000117834), score: 0.69 SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19 (ENSG00000174358), score: 0.86 SRMSsrc-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (ENSG00000125508), score: 0.85 ST14suppression of tumorigenicity 14 (colon carcinoma) (ENSG00000149418), score: 0.62 SUSD2sushi domain containing 2 (ENSG00000099994), score: 0.74 TFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta) (ENSG00000008196), score: 0.63 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.64 TINAGtubulointerstitial nephritis antigen (ENSG00000137251), score: 0.65 TMEM171transmembrane protein 171 (ENSG00000157111), score: 0.73 TMEM27transmembrane protein 27 (ENSG00000147003), score: 0.72 TMPRSS13transmembrane protease, serine 13 (ENSG00000137747), score: 0.85 TRPM6transient receptor potential cation channel, subfamily M, member 6 (ENSG00000119121), score: 0.72 WNK1WNK lysine deficient protein kinase 1 (ENSG00000060237), score: 0.62 XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (ENSG00000122121), score: 0.7

Non-Entrez genes

Unknown, score:

Id	species	tissue	sex	individual
hsa_kd_m1_ca1	hsa	kd	m	1
oan_kd_m_ca1	oan	kd	m	_
gga_kd_f_ca1	gga	kd	f	_
mdo_kd_m_ca1	mdo	kd	m	_
gga_kd_m_ca1	gga	kd	m	_
mdo_kd_f_ca1	mdo	kd	f	_
oan_kd_f_ca1	oan	kd	f	_