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Expression data for module #242

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

immune effector process

Any process of the immune system that occurs as part of an immune response.

activation of immune response

Any process that initiates an immune response.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

leukocyte mediated immunity

Any process involved in the carrying out of an immune response by a leukocyte.

lymphocyte mediated immunity

Any process involved in the carrying out of an immune response by a lymphocyte.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

protein maturation by peptide bond cleavage

The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein.

porphyrin metabolic process

The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

humoral immune response

An immune response mediated through a body fluid.

cellular defense response

A defense response that is mediated by cells.

hemostasis

The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cell death

A biological process that results in permanent cessation of all vital functions of a cell.

cytolysis

The rupture of cell membranes and the loss of cytoplasm.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

gene expression

The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

death

A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.

protein processing

Any protein maturation process achieved by the cleavage of peptide bonds.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

tetrapyrrole metabolic process

The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

fibrinolysis

An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

heterocycle metabolic process

The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

coagulation

The process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

regulation of coagulation

Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

positive regulation of coagulation

Any process that activates or increases the frequency, rate or extent of coagulation.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

cofactor metabolic process

The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

regulation of fibrinolysis

Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

negative regulation of fibrinolysis

Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

regulation of wound healing

Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

regulation of response to stress

Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

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cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

cell death

A biological process that results in permanent cessation of all vital functions of a cell.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

immune effector process

Any process of the immune system that occurs as part of an immune response.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of coagulation

Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

positive regulation of coagulation

Any process that activates or increases the frequency, rate or extent of coagulation.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

negative regulation of fibrinolysis

Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

regulation of response to stress

Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

tetrapyrrole metabolic process

The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.

porphyrin metabolic process

The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

activation of immune response

Any process that initiates an immune response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

positive regulation of coagulation

Any process that activates or increases the frequency, rate or extent of coagulation.

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

negative regulation of fibrinolysis

Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

regulation of wound healing

Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

regulation of fibrinolysis

Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

negative regulation of fibrinolysis

Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

Help | Hide | Top The GO tree — Cellular Components

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plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

stored secretory granule

A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.

external side of plasma membrane

The side of the plasma membrane that is opposite to the side that faces the cytoplasm.

cell surface

The external part of the cell wall and/or plasma membrane.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

cytoplasmic membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

platelet alpha granule

A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).

platelet alpha granule lumen

The volume enclosed by the membrane of the platelet alpha granule.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cytoplasmic vesicle

A vesicle formed of membrane or protein, found in the cytoplasm of a cell.

membrane-enclosed lumen

The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

vesicle

Any small, fluid-filled, spherical organelle enclosed by membrane or protein.

vesicle lumen

The volume enclosed by the membrane or protein that forms a vesicle.

membrane-bounded vesicle

Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cytoplasmic vesicle part

Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

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extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

cytoplasmic vesicle

A vesicle formed of membrane or protein, found in the cytoplasm of a cell.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

cytoplasmic vesicle part

Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.

cytoplasmic membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

vesicle lumen

The volume enclosed by the membrane or protein that forms a vesicle.

cytoplasmic membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

cytoplasmic vesicle

A vesicle formed of membrane or protein, found in the cytoplasm of a cell.

cytoplasmic vesicle part

Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

external side of plasma membrane

The side of the plasma membrane that is opposite to the side that faces the cytoplasm.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

platelet alpha granule lumen

The volume enclosed by the membrane of the platelet alpha granule.

Help | Hide | Top The GO tree — Molecular Function

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molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

enzyme inhibitor activity

Stops, prevents or reduces the activity of an enzyme.

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

enzyme regulator activity

Modulates the activity of an enzyme.

peptidase regulator activity

Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

all

NA

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04610 1.435e-09 0.6333 11
21 Complement and coagulation cascades
05020 2.047e-02 0.392 4
13 Prion diseases
05322 3.138e-02 0.4524 4
15 Systemic lupus erythematosus
04670 4.836e-02 1.297 6
43 Leukocyte transendothelial migration

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ABCG5ATP-binding cassette, sub-family G (WHITE), member 5 (ENSG00000138075), score: 0.59 ALG9asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae) (ENSG00000086848), score: 0.66 ALPK1alpha-kinase 1 (ENSG00000073331), score: 0.59 AMBPalpha-1-microglobulin/bikunin precursor (ENSG00000106927), score: 0.61 ANKRD22ankyrin repeat domain 22 (ENSG00000152766), score: 0.68 APBB1IPamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein (ENSG00000077420), score: 0.6 AQP8aquaporin 8 (ENSG00000103375), score: 0.63 ATF3activating transcription factor 3 (ENSG00000162772), score: 0.57 BMP10bone morphogenetic protein 10 (ENSG00000163217), score: 0.68 BMPERBMP binding endothelial regulator (ENSG00000164619), score: 0.66 BPIL3bactericidal/permeability-increasing protein-like 3 (ENSG00000167104), score: 0.92 BST1bone marrow stromal cell antigen 1 (ENSG00000109743), score: 0.62 C5complement component 5 (ENSG00000106804), score: 0.59 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.64 C8Bcomplement component 8, beta polypeptide (ENSG00000021852), score: 0.66 C8Gcomplement component 8, gamma polypeptide (ENSG00000176919), score: 0.57 C9orf72chromosome 9 open reading frame 72 (ENSG00000147894), score: 0.63 CCNIcyclin I (ENSG00000118816), score: -0.6 CCNL1cyclin L1 (ENSG00000163660), score: 0.66 CLDN14claudin 14 (ENSG00000159261), score: 0.72 CNGA1cyclic nucleotide gated channel alpha 1 (ENSG00000198515), score: 0.62 COLEC10collectin sub-family member 10 (C-type lectin) (ENSG00000184374), score: 0.67 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.66 CSF3Rcolony stimulating factor 3 receptor (granulocyte) (ENSG00000119535), score: 0.59 CXCR4chemokine (C-X-C motif) receptor 4 (ENSG00000121966), score: 0.57 CYTIPcytohesin 1 interacting protein (ENSG00000115165), score: 0.66 DBHdopamine beta-hydroxylase (dopamine beta-monooxygenase) (ENSG00000123454), score: 0.65 DHODHdihydroorotate dehydrogenase (ENSG00000102967), score: 0.86 F10coagulation factor X (ENSG00000126218), score: 0.57 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.58 F9coagulation factor IX (ENSG00000101981), score: 0.57 FAM83Afamily with sequence similarity 83, member A (ENSG00000147689), score: 1 FGBfibrinogen beta chain (ENSG00000171564), score: 0.65 FGGfibrinogen gamma chain (ENSG00000171557), score: 0.66 FOXF1forkhead box F1 (ENSG00000103241), score: 0.63 FSTfollistatin (ENSG00000134363), score: 0.78 GADD45Bgrowth arrest and DNA-damage-inducible, beta (ENSG00000099860), score: 0.64 GAS2growth arrest-specific 2 (ENSG00000148935), score: 0.57 GDF2growth differentiation factor 2 (ENSG00000128802), score: 0.59 GPR183G protein-coupled receptor 183 (ENSG00000169508), score: 0.75 GPR97G protein-coupled receptor 97 (ENSG00000182885), score: 0.92 GRAP2GRB2-related adaptor protein 2 (ENSG00000100351), score: 0.78 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.62 HAO1hydroxyacid oxidase (glycolate oxidase) 1 (ENSG00000101323), score: 0.58 HGFhepatocyte growth factor (hepapoietin A; scatter factor) (ENSG00000019991), score: 0.67 HPXhemopexin (ENSG00000110169), score: 0.61 HRGhistidine-rich glycoprotein (ENSG00000113905), score: 0.57 IFNGR1interferon gamma receptor 1 (ENSG00000027697), score: 0.62 IGFBP1insulin-like growth factor binding protein 1 (ENSG00000146678), score: 0.62 IHHIndian hedgehog (ENSG00000163501), score: 0.57 IL18RAPinterleukin 18 receptor accessory protein (ENSG00000115607), score: 0.97 IL1R2interleukin 1 receptor, type II (ENSG00000115590), score: 0.81 IL2RBinterleukin 2 receptor, beta (ENSG00000100385), score: 0.64 IL7Rinterleukin 7 receptor (ENSG00000168685), score: 0.67 IRF4interferon regulatory factor 4 (ENSG00000137265), score: 0.68 ITKIL2-inducible T-cell kinase (ENSG00000113263), score: 0.79 KCTD2potassium channel tetramerisation domain containing 2 (ENSG00000180901), score: -0.7 KIAA0146KIAA0146 (ENSG00000164808), score: 0.62 LECT2leukocyte cell-derived chemotaxin 2 (ENSG00000145826), score: 0.61 LOC100292202similar to solute carrier family 25, member 25 (ENSG00000148339), score: 0.66 LYVE1lymphatic vessel endothelial hyaluronan receptor 1 (ENSG00000133800), score: 0.57 MMABmethylmalonic aciduria (cobalamin deficiency) cblB type (ENSG00000139428), score: 0.58 MTHFD2Lmethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like (ENSG00000163738), score: 0.9 MXD1MAX dimerization protein 1 (ENSG00000059728), score: 0.65 MYO1Bmyosin IB (ENSG00000128641), score: 0.62 MYO1Fmyosin IF (ENSG00000142347), score: 0.69 NCF2neutrophil cytosolic factor 2 (ENSG00000116701), score: 0.6 NCF4neutrophil cytosolic factor 4, 40kDa (ENSG00000100365), score: 0.65 NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (ENSG00000144802), score: 0.59 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.61 NRBF2nuclear receptor binding factor 2 (ENSG00000148572), score: 0.76 NT5M5',3'-nucleotidase, mitochondrial (ENSG00000205309), score: -0.68 NTF3neurotrophin 3 (ENSG00000185652), score: 0.57 OIT3oncoprotein induced transcript 3 (ENSG00000138315), score: 0.7 PPIBpeptidylprolyl isomerase B (cyclophilin B) (ENSG00000166794), score: 0.57 PRDM1PR domain containing 1, with ZNF domain (ENSG00000057657), score: 0.72 PROZprotein Z, vitamin K-dependent plasma glycoprotein (ENSG00000126231), score: 0.58 R3HDMLR3H domain containing-like (ENSG00000101074), score: 0.58 RHOHras homolog gene family, member H (ENSG00000168421), score: 0.62 RND3Rho family GTPase 3 (ENSG00000115963), score: 0.66 S1PR4sphingosine-1-phosphate receptor 4 (ENSG00000125910), score: 0.74 SAMSN1SAM domain, SH3 domain and nuclear localization signals 1 (ENSG00000155307), score: 0.85 SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (ENSG00000140093), score: 0.7 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.6 SH2D2ASH2 domain containing 2A (ENSG00000027869), score: 0.6 SIK1salt-inducible kinase 1 (ENSG00000142178), score: 0.63 SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (ENSG00000018280), score: 0.57 SLC13A5solute carrier family 13 (sodium-dependent citrate transporter), member 5 (ENSG00000141485), score: 0.7 SLC20A1solute carrier family 20 (phosphate transporter), member 1 (ENSG00000144136), score: 0.63 SLC25A38solute carrier family 25, member 38 (ENSG00000144659), score: 0.58 ST6GAL1ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 (ENSG00000073849), score: 0.57 STAB2stabilin 2 (ENSG00000136011), score: 0.58 TATtyrosine aminotransferase (ENSG00000198650), score: 0.64 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.65 TEFthyrotrophic embryonic factor (ENSG00000167074), score: -0.64 TGDSTDP-glucose 4,6-dehydratase (ENSG00000088451), score: 0.7 TM4SF4transmembrane 4 L six family member 4 (ENSG00000169903), score: 0.6 TMED6transmembrane emp24 protein transport domain containing 6 (ENSG00000157315), score: 0.75 TOB1transducer of ERBB2, 1 (ENSG00000141232), score: 0.77 TRAT1T cell receptor associated transmembrane adaptor 1 (ENSG00000163519), score: 0.68 TRIB1tribbles homolog 1 (Drosophila) (ENSG00000173334), score: 0.6 TRPM8transient receptor potential cation channel, subfamily M, member 8 (ENSG00000144481), score: 0.68 TSTA3tissue specific transplantation antigen P35B (ENSG00000104522), score: 0.6 TTPALtocopherol (alpha) transfer protein-like (ENSG00000124120), score: 0.67 TXNDC12thioredoxin domain containing 12 (endoplasmic reticulum) (ENSG00000117862), score: 0.58 USP2ubiquitin specific peptidase 2 (ENSG00000036672), score: -0.71 ZNF827zinc finger protein 827 (ENSG00000151612), score: -0.59

Non-Entrez genes

Unknown, score:

Help | Hide | Top Conditions

Id species tissue sex individual
ppy_lv_m_ca1 ppy lv m _
ppa_lv_f_ca1 ppa lv f _
ppy_lv_f_ca1 ppy lv f _

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