Under-expression is coded with green,
over-expression with red color.
heart morphogenesis
The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
system process
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
muscle system process
A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
circulatory system process
A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
heart process
A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
muscle contraction
A process whereby force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
transport
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.
striated muscle contraction
A process whereby force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
organ morphogenesis
Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
heart development
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
muscle organ development
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
blood circulation
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
actin filament-based movement
Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
striated muscle tissue development
The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.
actin filament-based process
Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.
muscle filament sliding
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
cytoskeleton-dependent intracellular transport
The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
actin-myosin filament sliding
The sliding movement of actin thin filaments and myosin thick filaments past each other.
intracellular transport
The directed movement of substances within a cell.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue morphogenesis
The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
cardiac muscle tissue development
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
localization
Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
cellular localization
Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
establishment of localization in cell
The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.
heart contraction
The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.
cardiac muscle contraction
Muscle contraction of cardiac muscle tissue.
muscle tissue morphogenesis
The process by which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. Morphogenesis pertains to the creation of form.
muscle tissue development
The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.
muscle structure development
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
actin-mediated cell contraction
The actin filament-based process by which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.
all
NA
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
cellular localization
Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
establishment of localization in cell
The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
intracellular transport
The directed movement of substances within a cell.
actin-myosin filament sliding
The sliding movement of actin thin filaments and myosin thick filaments past each other.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue morphogenesis
The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.
tissue morphogenesis
The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.
organ morphogenesis
Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
muscle organ development
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
muscle filament sliding
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
heart contraction
The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.
cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.
heart morphogenesis
The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
muscle tissue development
The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.
actin filament-based movement
Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.
cardiac muscle contraction
Muscle contraction of cardiac muscle tissue.
cardiac muscle tissue development
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
cardiac muscle tissue morphogenesis
The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
contractile fiber
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
mitochondrion
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
endoplasmic reticulum
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
cytoplasm
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial envelope
The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
cytoskeleton
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
muscle myosin complex
A filament of myosin found in a muscle cell of any type.
actin cytoskeleton
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
myosin complex
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
myosin II complex
A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures.
sarcoplasm
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
sarcoplasmic reticulum
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
myofibril
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
sarcomere
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
organelle membrane
The lipid bilayer surrounding an organelle.
I band
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
mitochondrial membrane
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
organelle envelope
A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
envelope
A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
sarcolemma
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
protein complex
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
mitochondrial part
Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
contractile fiber part
Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
mitochondrial membrane part
Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
subsynaptic reticulum
An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
all
NA
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
organelle membrane
The lipid bilayer surrounding an organelle.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
organelle envelope
A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
organelle membrane
The lipid bilayer surrounding an organelle.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
organelle envelope
A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
mitochondrial membrane part
Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrial envelope
The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
mitochondrial membrane
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrial membrane part
Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
myosin complex
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
I band
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
contractile fiber
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
mitochondrion
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
endoplasmic reticulum
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
mitochondrial part
Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
contractile fiber part
Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
subsynaptic reticulum
An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
muscle myosin complex
A filament of myosin found in a muscle cell of any type.
mitochondrial membrane
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrial part
Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
sarcoplasmic reticulum
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
contractile fiber part
Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
sarcoplasmic reticulum
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
sarcomere
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
myosin complex
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 05414 | 1.110e-03 | 0.8408 | 7 | 34 | Dilated cardiomyopathy |
| 05410 | 7.947e-03 | 0.8408 | 6 | 34 | Hypertrophic cardiomyopathy (HCM) |
| 00020 | 1.461e-02 | 0.3462 | 4 | 14 | Citrate cycle (TCA cycle) |
| 05412 | 3.094e-02 | 0.7666 | 5 | 31 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
ABRAactin-binding Rho activating protein (ENSG00000174429), score: 0.4 ACSL3acyl-CoA synthetase long-chain family member 3 (ENSG00000123983), score: -0.39 ADAMTSL5ADAMTS-like 5 (ENSG00000185761), score: 0.4 ANGPT1angiopoietin 1 (ENSG00000154188), score: 0.43 ANKRD1ankyrin repeat domain 1 (cardiac muscle) (ENSG00000148677), score: 0.36 ART3ADP-ribosyltransferase 3 (ENSG00000156219), score: 0.37 ASB11ankyrin repeat and SOCS box-containing 11 (ENSG00000165192), score: 0.53 ASB14ankyrin repeat and SOCS box-containing 14 (ENSG00000239388), score: 0.43 ASB15ankyrin repeat and SOCS box-containing 15 (ENSG00000146809), score: 0.37 ASB2ankyrin repeat and SOCS box-containing 2 (ENSG00000100628), score: 0.38 ATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ENSG00000174437), score: 0.5 BLKB lymphoid tyrosine kinase (ENSG00000136573), score: 0.37 BMP10bone morphogenetic protein 10 (ENSG00000163217), score: 0.36 C14orf1chromosome 14 open reading frame 1 (ENSG00000133935), score: -0.4 C3orf75chromosome 3 open reading frame 75 (ENSG00000163832), score: -0.38 CACNA1Scalcium channel, voltage-dependent, L type, alpha 1S subunit (ENSG00000081248), score: 0.6 CADM1cell adhesion molecule 1 (ENSG00000182985), score: -0.47 CCRL1chemokine (C-C motif) receptor-like 1 (ENSG00000129048), score: 0.37 CD274CD274 molecule (ENSG00000120217), score: 0.36 CD28CD28 molecule (ENSG00000178562), score: 0.42 CDK8cyclin-dependent kinase 8 (ENSG00000132964), score: 0.46 CHRNA10cholinergic receptor, nicotinic, alpha 10 (ENSG00000129749), score: 0.45 CNSTconsortin, connexin sorting protein (ENSG00000162852), score: 0.36 COQ5coenzyme Q5 homolog, methyltransferase (S. cerevisiae) (ENSG00000110871), score: 0.36 CYTL1cytokine-like 1 (ENSG00000170891), score: 0.63 DAPP1dual adaptor of phosphotyrosine and 3-phosphoinositides (ENSG00000070190), score: 0.39 DLSTdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (ENSG00000119689), score: 0.36 DSPdesmoplakin (ENSG00000096696), score: 0.37 DUSP14dual specificity phosphatase 14 (ENSG00000161326), score: -0.41 DYMdymeclin (ENSG00000141627), score: 0.36 EGLN1egl nine homolog 1 (C. elegans) (ENSG00000135766), score: 0.46 EHD4EH-domain containing 4 (ENSG00000103966), score: 0.45 ENTPD4ectonucleoside triphosphate diphosphohydrolase 4 (ENSG00000197217), score: 0.38 ETFDHelectron-transferring-flavoprotein dehydrogenase (ENSG00000171503), score: 0.38 FAAHfatty acid amide hydrolase (ENSG00000117480), score: -0.42 FAM160A1family with sequence similarity 160, member A1 (ENSG00000164142), score: 0.45 FAM174Bfamily with sequence similarity 174, member B (ENSG00000185442), score: 0.53 FAM189A2family with sequence similarity 189, member A2 (ENSG00000135063), score: 0.36 FBLIM1filamin binding LIM protein 1 (ENSG00000162458), score: 0.37 FBP2fructose-1,6-bisphosphatase 2 (ENSG00000130957), score: 0.39 FBXO40F-box protein 40 (ENSG00000163833), score: 0.37 FMR1fragile X mental retardation 1 (ENSG00000102081), score: -0.39 FSD2fibronectin type III and SPRY domain containing 2 (ENSG00000186628), score: 0.41 FYCO1FYVE and coiled-coil domain containing 1 (ENSG00000163820), score: 0.39 GJA3gap junction protein, alpha 3, 46kDa (ENSG00000121743), score: 0.39 GOLGA4golgin A4 (ENSG00000144674), score: 0.41 H1FXH1 histone family, member X (ENSG00000184897), score: -0.48 HADHAhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (ENSG00000084754), score: 0.37 HIPK3homeodomain interacting protein kinase 3 (ENSG00000110422), score: 0.42 IDH3Aisocitrate dehydrogenase 3 (NAD+) alpha (ENSG00000166411), score: 0.37 IL10RBinterleukin 10 receptor, beta (ENSG00000243646), score: 0.4 IL15interleukin 15 (ENSG00000164136), score: 0.38 IVNS1ABPinfluenza virus NS1A binding protein (ENSG00000116679), score: 0.48 KBTBD5kelch repeat and BTB (POZ) domain containing 5 (ENSG00000157119), score: 0.39 KCNJ5potassium inwardly-rectifying channel, subfamily J, member 5 (ENSG00000120457), score: 0.48 KCNV2potassium channel, subfamily V, member 2 (ENSG00000168263), score: 0.68 KIAA0100KIAA0100 (ENSG00000007202), score: 0.36 KIF13Akinesin family member 13A (ENSG00000137177), score: 0.4 KLHL24kelch-like 24 (Drosophila) (ENSG00000114796), score: 0.38 LCLAT1lysocardiolipin acyltransferase 1 (ENSG00000172954), score: 0.42 LMOD2leiomodin 2 (cardiac) (ENSG00000170807), score: 0.37 LMOD3leiomodin 3 (fetal) (ENSG00000163380), score: 0.57 LOC100131693eukaryotic translation initiation factor 4E pseudogene (ENSG00000151247), score: 0.37 LRRC10leucine rich repeat containing 10 (ENSG00000198812), score: 0.45 LRRC15leucine rich repeat containing 15 (ENSG00000172061), score: 0.48 LRRC2leucine rich repeat containing 2 (ENSG00000163827), score: 0.41 LRRC39leucine rich repeat containing 39 (ENSG00000122477), score: 0.38 LRTM1leucine-rich repeats and transmembrane domains 1 (ENSG00000144771), score: 1 LSSlanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (ENSG00000160285), score: -0.45 LZICleucine zipper and CTNNBIP1 domain containing (ENSG00000162441), score: 0.36 MAP1Dmethionine aminopeptidase 1D (ENSG00000172878), score: 0.38 MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha (ENSG00000101460), score: 0.38 MEAF6MYST/Esa1-associated factor 6 (ENSG00000163875), score: -0.39 MFN1mitofusin 1 (ENSG00000171109), score: 0.47 MFN2mitofusin 2 (ENSG00000116688), score: 0.38 MOV10L1Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) (ENSG00000073146), score: 0.41 MRPS23mitochondrial ribosomal protein S23 (ENSG00000181610), score: 0.38 MURCmuscle-related coiled-coil protein (ENSG00000170681), score: 0.39 MYBPC3myosin binding protein C, cardiac (ENSG00000134571), score: 0.36 MYL1myosin, light chain 1, alkali; skeletal, fast (ENSG00000168530), score: 0.57 MYL4myosin, light chain 4, alkali; atrial, embryonic (ENSG00000198336), score: 0.36 MYLK3myosin light chain kinase 3 (ENSG00000140795), score: 0.44 MYLK4myosin light chain kinase family, member 4 (ENSG00000145949), score: 0.64 MYOCDmyocardin (ENSG00000141052), score: 0.45 MYOZ2myozenin 2 (ENSG00000172399), score: 0.37 MYPNmyopalladin (ENSG00000138347), score: 0.4 NDUFA10NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa (ENSG00000130414), score: 0.36 NDUFA8NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa (ENSG00000119421), score: 0.38 NDUFB9NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa (ENSG00000147684), score: 0.36 NEDD4neural precursor cell expressed, developmentally down-regulated 4 (ENSG00000069869), score: 0.42 NEK9NIMA (never in mitosis gene a)- related kinase 9 (ENSG00000119638), score: 0.36 NIPSNAP1nipsnap homolog 1 (C. elegans) (ENSG00000184117), score: -0.41 NSMAFneutral sphingomyelinase (N-SMase) activation associated factor (ENSG00000035681), score: 0.39 OGDHoxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (ENSG00000105953), score: 0.47 PCGF5polycomb group ring finger 5 (ENSG00000180628), score: 0.36 PDHBpyruvate dehydrogenase (lipoamide) beta (ENSG00000168291), score: 0.41 PHTF2putative homeodomain transcription factor 2 (ENSG00000006576), score: 0.58 PIGPphosphatidylinositol glycan anchor biosynthesis, class P (ENSG00000185808), score: 0.37 PLNphospholamban (ENSG00000198523), score: 0.38 PPP1R3Aprotein phosphatase 1, regulatory (inhibitor) subunit 3A (ENSG00000154415), score: 0.42 PSMD12proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 (ENSG00000197170), score: 0.36 PTGR2prostaglandin reductase 2 (ENSG00000140043), score: 0.36 PTPN11protein tyrosine phosphatase, non-receptor type 11 (ENSG00000179295), score: 0.37 RALGAPA2Ral GTPase activating protein, alpha subunit 2 (catalytic) (ENSG00000188559), score: 0.4 RAPSNreceptor-associated protein of the synapse (ENSG00000165917), score: 0.54 RNF139ring finger protein 139 (ENSG00000170881), score: 0.42 RPL3Lribosomal protein L3-like (ENSG00000140986), score: 0.37 SESN1sestrin 1 (ENSG00000080546), score: 0.36 SGCBsarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (ENSG00000163069), score: 0.36 SGCGsarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) (ENSG00000102683), score: 0.43 SMYD1SET and MYND domain containing 1 (ENSG00000115593), score: 0.37 SSPNsarcospan (Kras oncogene-associated gene) (ENSG00000123096), score: 0.42 STRN3striatin, calmodulin binding protein 3 (ENSG00000196792), score: 0.37 TAF1ATATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa (ENSG00000143498), score: 0.36 TCP11L2t-complex 11 (mouse)-like 2 (ENSG00000166046), score: 0.41 TEAD1TEA domain family member 1 (SV40 transcriptional enhancer factor) (ENSG00000187079), score: 0.42 TIMM17Atranslocase of inner mitochondrial membrane 17 homolog A (yeast) (ENSG00000134375), score: 0.39 TMEM182transmembrane protein 182 (ENSG00000170417), score: 0.37 TMEM38Atransmembrane protein 38A (ENSG00000072954), score: 0.41 TPM1tropomyosin 1 (alpha) (ENSG00000140416), score: 0.36 TXLNBtaxilin beta (ENSG00000164440), score: 0.47 UBR2ubiquitin protein ligase E3 component n-recognin 2 (ENSG00000024048), score: 0.42 UCP3uncoupling protein 3 (mitochondrial, proton carrier) (ENSG00000175564), score: 0.51 USP28ubiquitin specific peptidase 28 (ENSG00000048028), score: 0.38 WDR89WD repeat domain 89 (ENSG00000140006), score: 0.4 ZC3H7Azinc finger CCCH-type containing 7A (ENSG00000122299), score: 0.5
| Id | species | tissue | sex | individual |
|---|---|---|---|---|
| mmu_ht_f_ca1 | mmu | ht | f | _ |
| mmu_ht_m1_ca1 | mmu | ht | m | 1 |
| mmu_ht_m2_ca1 | mmu | ht | m | 2 |
