Previous module | Next module Module #254, TG: 2.4, TC: 2.8, 92 probes, 91 Entrez genes, 7 conditions

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Expression data for module #254

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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M phase

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

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NA

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

Help | Hide | Top The GO tree — Cellular Components

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intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

microtubule organizing center

A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

spindle microtubule

Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

microtubule organizing center

A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

spindle microtubule

Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

microtubule organizing center

A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

Help | Hide | Top The GO tree — Molecular Function

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Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

No enriched terms

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ADAD1adenosine deaminase domain containing 1 (testis-specific) (ENSG00000164113), score: 0.8 AGBL5ATP/GTP binding protein-like 5 (ENSG00000084693), score: 0.73 ANKLE2ankyrin repeat and LEM domain containing 2 (ENSG00000176915), score: 0.74 ARHGAP28Rho GTPase activating protein 28 (ENSG00000088756), score: 0.87 ARMC4armadillo repeat containing 4 (ENSG00000169126), score: 0.82 AURKAaurora kinase A (ENSG00000087586), score: 0.71 BARX1BARX homeobox 1 (ENSG00000131668), score: 0.85 BOLLbol, boule-like (Drosophila) (ENSG00000152430), score: 0.83 BRIP1BRCA1 interacting protein C-terminal helicase 1 (ENSG00000136492), score: 0.88 BTG4B-cell translocation gene 4 (ENSG00000137707), score: 0.89 BUB1budding uninhibited by benzimidazoles 1 homolog (yeast) (ENSG00000169679), score: 0.72 C10orf96chromosome 10 open reading frame 96 (ENSG00000182645), score: 0.84 C19orf45chromosome 19 open reading frame 45 (ENSG00000198723), score: 0.74 C1orf158chromosome 1 open reading frame 158 (ENSG00000157330), score: 0.73 C1orf59chromosome 1 open reading frame 59 (ENSG00000162639), score: 0.77 C20orf85chromosome 20 open reading frame 85 (ENSG00000124237), score: 0.71 C7orf62chromosome 7 open reading frame 62 (ENSG00000164645), score: 0.77 CALR3calreticulin 3 (ENSG00000141979), score: 0.72 CCDC135coiled-coil domain containing 135 (ENSG00000159625), score: 0.71 CCDC83coiled-coil domain containing 83 (ENSG00000150676), score: 0.81 CDKN3cyclin-dependent kinase inhibitor 3 (ENSG00000100526), score: 0.74 CEP55centrosomal protein 55kDa (ENSG00000138180), score: 0.75 CHODLchondrolectin (ENSG00000154645), score: 0.82 CLCA2chloride channel accessory 2 (ENSG00000137975), score: 1 DDX20DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 (ENSG00000064703), score: 0.77 DDX4DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 (ENSG00000152670), score: 0.74 DNAI2dynein, axonemal, intermediate chain 2 (ENSG00000171595), score: 0.76 DNAJC5BDnaJ (Hsp40) homolog, subfamily C, member 5 beta (ENSG00000147570), score: 0.83 DRG1developmentally regulated GTP binding protein 1 (ENSG00000185721), score: 0.74 DTLdenticleless homolog (Drosophila) (ENSG00000143476), score: 0.85 DYDC1DPY30 domain containing 1 (ENSG00000170788), score: 0.82 EVX1even-skipped homeobox 1 (ENSG00000106038), score: 0.79 FAM194Afamily with sequence similarity 194, member A (ENSG00000163645), score: 0.76 FAM81Bfamily with sequence similarity 81, member B (ENSG00000153347), score: 0.76 FBXO43F-box protein 43 (ENSG00000156509), score: 0.71 GJA8gap junction protein, alpha 8, 50kDa (ENSG00000121634), score: 0.93 GMPSguanine monphosphate synthetase (ENSG00000163655), score: 0.8 GRHL3grainyhead-like 3 (Drosophila) (ENSG00000158055), score: 0.73 GSG1germ cell associated 1 (ENSG00000111305), score: 0.95 GTF2A2general transcription factor IIA, 2, 12kDa (ENSG00000140307), score: 0.72 HSF2BPheat shock transcription factor 2 binding protein (ENSG00000160207), score: 0.83 IFT88intraflagellar transport 88 homolog (Chlamydomonas) (ENSG00000032742), score: 0.75 ISG20L2interferon stimulated exonuclease gene 20kDa-like 2 (ENSG00000143319), score: 0.76 KDM1Alysine (K)-specific demethylase 1A (ENSG00000004487), score: 0.71 KDM4Alysine (K)-specific demethylase 4A (ENSG00000066135), score: -0.74 KIF11kinesin family member 11 (ENSG00000138160), score: 0.73 KIF18Akinesin family member 18A (ENSG00000121621), score: 0.8 KNTC1kinetochore associated 1 (ENSG00000184445), score: 0.8 LASS3LAG1 homolog, ceramide synthase 3 (ENSG00000154227), score: 0.92 LOC81691exonuclease NEF-sp (ENSG00000005189), score: 0.94 LOXHD1lipoxygenase homology domains 1 (ENSG00000167210), score: 0.87 LRIT1leucine-rich repeat, immunoglobulin-like and transmembrane domains 1 (ENSG00000148602), score: 0.93 LRRCC1leucine rich repeat and coiled-coil domain containing 1 (ENSG00000133739), score: 0.75 MC2Rmelanocortin 2 receptor (adrenocorticotropic hormone) (ENSG00000185231), score: 0.92 MYO15Amyosin XVA (ENSG00000091536), score: 0.71 NEK2NIMA (never in mitosis gene a)-related kinase 2 (ENSG00000117650), score: 0.79 NEK5NIMA (never in mitosis gene a)-related kinase 5 (ENSG00000197168), score: 0.75 NSUN4NOP2/Sun domain family, member 4 (ENSG00000117481), score: 0.73 NUP155nucleoporin 155kDa (ENSG00000113569), score: 0.75 NUP214nucleoporin 214kDa (ENSG00000126883), score: 0.81 OPN5opsin 5 (ENSG00000124818), score: 0.87 PIAS4protein inhibitor of activated STAT, 4 (ENSG00000105229), score: 0.75 PIWIL1piwi-like 1 (Drosophila) (ENSG00000125207), score: 0.72 PPIL5peptidylprolyl isomerase (cyclophilin)-like 5 (ENSG00000165501), score: 0.78 PPM1Gprotein phosphatase, Mg2+/Mn2+ dependent, 1G (ENSG00000115241), score: 0.87 PROK1prokineticin 1 (ENSG00000143125), score: 0.72 PRTGprotogenin (ENSG00000166450), score: 0.95 RAE1RAE1 RNA export 1 homolog (S. pombe) (ENSG00000101146), score: 0.87 RFX2regulatory factor X, 2 (influences HLA class II expression) (ENSG00000087903), score: 0.76 RNF141ring finger protein 141 (ENSG00000110315), score: 0.8 RNF17ring finger protein 17 (ENSG00000132972), score: 0.72 ROPN1Lropporin 1-like (ENSG00000145491), score: 0.71 RTKN2rhotekin 2 (ENSG00000182010), score: 0.74 SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 5 (ENSG00000206075), score: 0.85 SLC26A8solute carrier family 26, member 8 (ENSG00000112053), score: 0.74 SMURF1SMAD specific E3 ubiquitin protein ligase 1 (ENSG00000198742), score: 0.77 SPACA1sperm acrosome associated 1 (ENSG00000118434), score: 0.75 SPATA17spermatogenesis associated 17 (ENSG00000162814), score: 0.77 SPATA4spermatogenesis associated 4 (ENSG00000150628), score: 0.74 SPSB4splA/ryanodine receptor domain and SOCS box containing 4 (ENSG00000175093), score: 0.74 TMEM215transmembrane protein 215 (ENSG00000188133), score: 0.9 TOMM40Ltranslocase of outer mitochondrial membrane 40 homolog (yeast)-like (ENSG00000158882), score: -0.7 TRIP12thyroid hormone receptor interactor 12 (ENSG00000153827), score: 0.73 TTC16tetratricopeptide repeat domain 16 (ENSG00000167094), score: 0.71 TTC29tetratricopeptide repeat domain 29 (ENSG00000137473), score: 0.82 USP6NLUSP6 N-terminal like (ENSG00000148429), score: 0.8 VPRBPVpr (HIV-1) binding protein (ENSG00000145041), score: 0.75 VRK3vaccinia related kinase 3 (ENSG00000105053), score: 0.8 ZBTB44zinc finger and BTB domain containing 44 (ENSG00000196323), score: 0.72 ZPBPzona pellucida binding protein (ENSG00000042813), score: 0.76 ZPBP2zona pellucida binding protein 2 (ENSG00000186075), score: 0.74

Non-Entrez genes

ENSG00000170788Unknown, score: 0.72

Help | Hide | Top Conditions

Id species tissue sex individual
hsa_ts_m1_ca1 hsa ts m 1
ggo_ts_m_ca1 ggo ts m _
hsa_ts_m2_ca1 hsa ts m 2
mml_ts_m1_ca1 mml ts m 1
mml_ts_m2_ca1 mml ts m 2
ppa_ts_m_ca1 ppa ts m _
ptr_ts_m_ca1 ptr ts m _

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