Previous module | Next module Module #259, TG: 2.4, TC: 2.8, 109 probes, 109 Entrez genes, 3 conditions

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Expression data for module #259

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

all

NA

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

Help | Hide | Top The GO tree — Cellular Components

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plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

organelle membrane

The lipid bilayer surrounding an organelle.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

all

NA

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

Help | Hide | Top The GO tree — Molecular Function

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Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04960 1.164e-02 0.3185 4
16 Aldosterone-regulated sodium reabsorption

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ACPPacid phosphatase, prostate (ENSG00000014257), score: 0.61 AGR2anterior gradient homolog 2 (Xenopus laevis) (ENSG00000106541), score: 0.48 ANXA13annexin A13 (ENSG00000104537), score: 0.45 ARMC7armadillo repeat containing 7 (ENSG00000125449), score: 0.56 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.54 ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (ENSG00000147614), score: 0.54 BARX2BARX homeobox 2 (ENSG00000043039), score: 0.64 BDKRB2bradykinin receptor B2 (ENSG00000168398), score: 0.57 BFSP2beaded filament structural protein 2, phakinin (ENSG00000170819), score: 0.85 C8orf84chromosome 8 open reading frame 84 (ENSG00000164764), score: 0.52 CA12carbonic anhydrase XII (ENSG00000074410), score: 0.55 CASRcalcium-sensing receptor (ENSG00000036828), score: 0.46 CDCP1CUB domain containing protein 1 (ENSG00000163814), score: 0.45 CLDN16claudin 16 (ENSG00000113946), score: 0.5 CLEC3AC-type lectin domain family 3, member A (ENSG00000166509), score: 0.54 COL4A3collagen, type IV, alpha 3 (Goodpasture antigen) (ENSG00000169031), score: 0.49 CPA1carboxypeptidase A1 (pancreatic) (ENSG00000091704), score: 0.46 CRYAAcrystallin, alpha A (ENSG00000160202), score: 0.79 CXCL14chemokine (C-X-C motif) ligand 14 (ENSG00000145824), score: 0.46 DBHdopamine beta-hydroxylase (dopamine beta-monooxygenase) (ENSG00000123454), score: 0.53 DDCdopa decarboxylase (aromatic L-amino acid decarboxylase) (ENSG00000132437), score: 0.47 DPEP1dipeptidase 1 (renal) (ENSG00000015413), score: 0.49 DRG2developmentally regulated GTP binding protein 2 (ENSG00000108591), score: 0.46 EBNA1BP2EBNA1 binding protein 2 (ENSG00000117395), score: 0.58 EGFepidermal growth factor (ENSG00000138798), score: 0.54 ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific ) (ENSG00000163435), score: 0.5 ELF5E74-like factor 5 (ets domain transcription factor) (ENSG00000135374), score: 0.57 EPCAMepithelial cell adhesion molecule (ENSG00000119888), score: 0.49 ESRP1epithelial splicing regulatory protein 1 (ENSG00000104413), score: 0.47 F2RL1coagulation factor II (thrombin) receptor-like 1 (ENSG00000164251), score: 0.56 F2RL3coagulation factor II (thrombin) receptor-like 3 (ENSG00000127533), score: 0.5 FAM3Bfamily with sequence similarity 3, member B (ENSG00000183844), score: 0.5 FAM83Bfamily with sequence similarity 83, member B (ENSG00000168143), score: 0.49 FOXI1forkhead box I1 (ENSG00000168269), score: 0.6 GALR1galanin receptor 1 (ENSG00000166573), score: 0.71 GATA3GATA binding protein 3 (ENSG00000107485), score: 0.51 GRHL2grainyhead-like 2 (Drosophila) (ENSG00000083307), score: 0.55 HOXA10homeobox A10 (ENSG00000153807), score: 0.61 HOXB7homeobox B7 (ENSG00000120087), score: 0.48 HOXD10homeobox D10 (ENSG00000128710), score: 0.53 HOXD4homeobox D4 (ENSG00000170166), score: 0.53 HSD11B2hydroxysteroid (11-beta) dehydrogenase 2 (ENSG00000176387), score: 0.51 IL1RL1interleukin 1 receptor-like 1 (ENSG00000115602), score: 0.63 ILDR1immunoglobulin-like domain containing receptor 1 (ENSG00000145103), score: 0.53 IMPA2inositol(myo)-1(or 4)-monophosphatase 2 (ENSG00000141401), score: 0.51 IMPG1interphotoreceptor matrix proteoglycan 1 (ENSG00000112706), score: 0.62 ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ENSG00000056345), score: 0.51 KANK3KN motif and ankyrin repeat domains 3 (ENSG00000186994), score: 0.51 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.58 KIF12kinesin family member 12 (ENSG00000136883), score: 0.44 KLHDC7Akelch domain containing 7A (ENSG00000179023), score: 0.51 LGALS2lectin, galactoside-binding, soluble, 2 (ENSG00000100079), score: 0.49 LMX1BLIM homeobox transcription factor 1, beta (ENSG00000136944), score: 0.68 LRMPlymphoid-restricted membrane protein (ENSG00000118308), score: 0.52 MDFIMyoD family inhibitor (ENSG00000112559), score: 0.45 METRNLmeteorin, glial cell differentiation regulator-like (ENSG00000176845), score: 0.47 MMP7matrix metallopeptidase 7 (matrilysin, uterine) (ENSG00000137673), score: 0.74 MYO19myosin XIX (ENSG00000141140), score: 0.49 NOX4NADPH oxidase 4 (ENSG00000086991), score: 0.53 NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin) (ENSG00000116218), score: 0.62 NPNTnephronectin (ENSG00000168743), score: 0.46 NPR3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) (ENSG00000113389), score: 0.49 OVCH2ovochymase 2 (gene/pseudogene) (ENSG00000183378), score: 0.9 PAPPApregnancy-associated plasma protein A, pappalysin 1 (ENSG00000182752), score: 0.51 PEPDpeptidase D (ENSG00000124299), score: 0.44 PLA2R1phospholipase A2 receptor 1, 180kDa (ENSG00000153246), score: 0.54 PLAUplasminogen activator, urokinase (ENSG00000122861), score: 0.48 PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific) (ENSG00000197943), score: 0.6 PNPLA1patatin-like phospholipase domain containing 1 (ENSG00000180316), score: 0.64 POLG2polymerase (DNA directed), gamma 2, accessory subunit (ENSG00000136480), score: 0.46 POLR3Bpolymerase (RNA) III (DNA directed) polypeptide B (ENSG00000013503), score: -0.51 PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit (ENSG00000111725), score: 0.47 PROM2prominin 2 (ENSG00000155066), score: 0.6 PTPRQprotein tyrosine phosphatase, receptor type, Q (ENSG00000139304), score: 0.48 R3HDMLR3H domain containing-like (ENSG00000101074), score: 0.5 RAB11FIP1RAB11 family interacting protein 1 (class I) (ENSG00000156675), score: 0.46 RHCGRh family, C glycoprotein (ENSG00000140519), score: 0.53 RNF152ring finger protein 152 (ENSG00000176641), score: 0.49 SAMD3sterile alpha motif domain containing 3 (ENSG00000164483), score: 0.49 SCINscinderin (ENSG00000006747), score: 0.47 SCNN1Asodium channel, nonvoltage-gated 1 alpha (ENSG00000111319), score: 0.52 SCNN1Gsodium channel, nonvoltage-gated 1, gamma (ENSG00000166828), score: 0.46 SFRP4secreted frizzled-related protein 4 (ENSG00000106483), score: 0.48 SH3YL1SH3 domain containing, Ysc84-like 1 (S. cerevisiae) (ENSG00000035115), score: 0.46 SIM1single-minded homolog 1 (Drosophila) (ENSG00000112246), score: 0.46 SIM2single-minded homolog 2 (Drosophila) (ENSG00000159263), score: 0.63 SLC15A1solute carrier family 15 (oligopeptide transporter), member 1 (ENSG00000088386), score: 0.49 SLC1A7solute carrier family 1 (glutamate transporter), member 7 (ENSG00000162383), score: 1 SLC26A7solute carrier family 26, member 7 (ENSG00000147606), score: 0.76 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 0.48 SLC44A3solute carrier family 44, member 3 (ENSG00000143036), score: 0.47 SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12 (ENSG00000148942), score: 0.49 SLC7A9solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 (ENSG00000021488), score: 0.48 SOSTDC1sclerostin domain containing 1 (ENSG00000171243), score: 0.55 STAP1signal transducing adaptor family member 1 (ENSG00000035720), score: 0.53 STK32Bserine/threonine kinase 32B (ENSG00000152953), score: 0.61 TBX2T-box 2 (ENSG00000121068), score: 0.49 TCOF1Treacher Collins-Franceschetti syndrome 1 (ENSG00000070814), score: 0.59 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.58 TINAGtubulointerstitial nephritis antigen (ENSG00000137251), score: 0.5 TMPRSS2transmembrane protease, serine 2 (ENSG00000184012), score: 0.52 TMPRSS4transmembrane protease, serine 4 (ENSG00000137648), score: 0.6 TNFSF15tumor necrosis factor (ligand) superfamily, member 15 (ENSG00000181634), score: 0.46 TRPV4transient receptor potential cation channel, subfamily V, member 4 (ENSG00000111199), score: 0.54 TSPAN2tetraspanin 2 (ENSG00000134198), score: 0.48 VCAM1vascular cell adhesion molecule 1 (ENSG00000162692), score: 0.56 WDR72WD repeat domain 72 (ENSG00000166415), score: 0.46 XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (ENSG00000122121), score: 0.45 ZC3H12Azinc finger CCCH-type containing 12A (ENSG00000163874), score: 0.48

Non-Entrez genes

Unknown, score:

Help | Hide | Top Conditions

Id species tissue sex individual
ptr_kd_f_ca1 ptr kd f _
ptr_kd_m_ca1 ptr kd m _
ppa_kd_f_ca1 ppa kd f _

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