Previous module | Next module Module #261, TG: 2.4, TC: 2.8, 90 probes, 90 Entrez genes, 5 conditions

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Expression data for module #261

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

glutamate metabolic process

The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.

cellular amino acid derivative metabolic process

The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.

coenzyme metabolic process

The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

lipid transport

The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

glutamine family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.

amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

lipid localization

Any process by which a lipid is transported to, or maintained in, a specific location.

carboxylic acid metabolic process

The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

monocarboxylic acid metabolic process

The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).

macromolecule localization

Any process by which a macromolecule is transported to, or maintained in, a specific location.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

homeostatic process

Any biological process involved in the maintenance of an internal steady-state.

cholesterol homeostasis

Any process involved in the maintenance of an internal steady-state of cholesterol within an organism or cell.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.

chemical homeostasis

Any biological process involved in the maintenance of an internal steady-state of a chemical.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

cofactor metabolic process

The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

lipid homeostasis

Any process involved in the maintenance of an internal steady-state of lipid within an organism or cell.

sterol homeostasis

Any process involved in the maintenance of an internal steady-state of sterol within an organism or cell.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

all

NA

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

lipid transport

The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

Help | Hide | Top The GO tree — Cellular Components

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cell fraction

A generic term for parts of cells prepared by disruptive biochemical techniques.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

Help | Hide | Top The GO tree — Molecular Function

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molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

lipid transporter activity

Enables the directed movement of lipids into, out of, within or between cells.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

sterol transporter activity

Enables the directed movement of sterols into, out of, within or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

carboxylic acid binding

Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

all

NA

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04610 1.143e-03 0.57 6
21 Complement and coagulation cascades
02010 1.785e-03 0.38 5
14 ABC transporters

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ABCA1ATP-binding cassette, sub-family A (ABC1), member 1 (ENSG00000165029), score: 0.62 ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ENSG00000073734), score: 0.71 ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ENSG00000023839), score: 0.57 ABCD3ATP-binding cassette, sub-family D (ALD), member 3 (ENSG00000117528), score: 0.69 ABCG5ATP-binding cassette, sub-family G (WHITE), member 5 (ENSG00000138075), score: 0.57 ACBD5acyl-CoA binding domain containing 5 (ENSG00000107897), score: 0.58 ACOT12acyl-CoA thioesterase 12 (ENSG00000172497), score: 0.66 ACSL5acyl-CoA synthetase long-chain family member 5 (ENSG00000197142), score: 0.61 ALBalbumin (ENSG00000163631), score: 0.58 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.62 AP3M1adaptor-related protein complex 3, mu 1 subunit (ENSG00000185009), score: 0.6 AQP8aquaporin 8 (ENSG00000103375), score: 0.81 ATL2atlastin GTPase 2 (ENSG00000119787), score: 0.59 AVPR1Aarginine vasopressin receptor 1A (ENSG00000166148), score: 0.71 B3GALT1UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 (ENSG00000172318), score: 0.57 B4GALT2UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (ENSG00000117411), score: -0.77 BBS2Bardet-Biedl syndrome 2 (ENSG00000125124), score: -0.89 BMP2bone morphogenetic protein 2 (ENSG00000125845), score: 0.59 C5complement component 5 (ENSG00000106804), score: 0.64 C8Bcomplement component 8, beta polypeptide (ENSG00000021852), score: 0.58 CCBL2cysteine conjugate-beta lyase 2 (ENSG00000137944), score: 0.63 CCRL1chemokine (C-C motif) receptor-like 1 (ENSG00000129048), score: 0.59 CNR2cannabinoid receptor 2 (macrophage) (ENSG00000188822), score: 0.83 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.6 CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1 (ENSG00000172817), score: 0.67 DERL1Der1-like domain family, member 1 (ENSG00000136986), score: 0.6 DERL2Der1-like domain family, member 2 (ENSG00000072849), score: 0.58 DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila) (ENSG00000160305), score: -0.71 DNAJC22DnaJ (Hsp40) homolog, subfamily C, member 22 (ENSG00000178401), score: 0.58 DNAJC3DnaJ (Hsp40) homolog, subfamily C, member 3 (ENSG00000102580), score: 0.64 DNTTdeoxynucleotidyltransferase, terminal (ENSG00000107447), score: 0.6 EGFRepidermal growth factor receptor (ENSG00000146648), score: 0.7 F10coagulation factor X (ENSG00000126218), score: 0.67 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.58 FABP2fatty acid binding protein 2, intestinal (ENSG00000145384), score: 1 FETUBfetuin B (ENSG00000090512), score: 0.7 GCH1GTP cyclohydrolase 1 (ENSG00000131979), score: 0.58 GCLMglutamate-cysteine ligase, modifier subunit (ENSG00000023909), score: 0.61 GLO1glyoxalase I (ENSG00000124767), score: 0.59 GNMTglycine N-methyltransferase (ENSG00000124713), score: 0.71 GPLD1glycosylphosphatidylinositol specific phospholipase D1 (ENSG00000112293), score: 0.78 H6PDhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (ENSG00000049239), score: 0.67 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.74 HEBP1heme binding protein 1 (ENSG00000013583), score: 0.59 IYDiodotyrosine deiodinase (ENSG00000009765), score: 0.68 LECT2leukocyte cell-derived chemotaxin 2 (ENSG00000145826), score: 0.72 LIPClipase, hepatic (ENSG00000166035), score: 0.69 LRIT2leucine-rich repeat, immunoglobulin-like and transmembrane domains 2 (ENSG00000204033), score: 0.57 LRRC15leucine rich repeat containing 15 (ENSG00000172061), score: 0.69 MARCH5membrane-associated ring finger (C3HC4) 5 (ENSG00000198060), score: 0.59 MAT1Amethionine adenosyltransferase I, alpha (ENSG00000151224), score: 0.64 MCM10minichromosome maintenance complex component 10 (ENSG00000065328), score: 0.6 MTTPmicrosomal triglyceride transfer protein (ENSG00000138823), score: 0.59 NPC1Niemann-Pick disease, type C1 (ENSG00000141458), score: 0.69 ONECUT1one cut homeobox 1 (ENSG00000169856), score: 0.67 OTCornithine carbamoyltransferase (ENSG00000036473), score: 0.77 P4HTMprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) (ENSG00000178467), score: -0.72 PANK1pantothenate kinase 1 (ENSG00000152782), score: 0.59 PEX11Aperoxisomal biogenesis factor 11 alpha (ENSG00000166821), score: 0.77 PIK3IP1phosphoinositide-3-kinase interacting protein 1 (ENSG00000100100), score: -0.77 PRKD3protein kinase D3 (ENSG00000115825), score: 0.57 PROZprotein Z, vitamin K-dependent plasma glycoprotein (ENSG00000126231), score: 0.62 PSEN2presenilin 2 (Alzheimer disease 4) (ENSG00000143801), score: 0.62 SDR42E1short chain dehydrogenase/reductase family 42E, member 1 (ENSG00000184860), score: 0.85 SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (ENSG00000140093), score: 0.62 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.58 SLC16A10solute carrier family 16, member 10 (aromatic amino acid transporter) (ENSG00000112394), score: 0.59 SLC17A8solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 (ENSG00000179520), score: 0.7 SLC25A47solute carrier family 25, member 47 (ENSG00000140107), score: 0.6 SLC2A9solute carrier family 2 (facilitated glucose transporter), member 9 (ENSG00000109667), score: 0.58 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.68 SLC7A2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (ENSG00000003989), score: 0.61 SLC7A6solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (ENSG00000103064), score: -0.82 SMYD4SET and MYND domain containing 4 (ENSG00000186532), score: -0.69 STARD5StAR-related lipid transfer (START) domain containing 5 (ENSG00000172345), score: 0.67 TATtyrosine aminotransferase (ENSG00000198650), score: 0.67 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.63 TMEM135transmembrane protein 135 (ENSG00000166575), score: 0.64 TMEM195transmembrane protein 195 (ENSG00000187546), score: 0.67 TMEM20transmembrane protein 20 (ENSG00000176273), score: 0.65 TSPAN3tetraspanin 3 (ENSG00000140391), score: -0.75 TTC39Ctetratricopeptide repeat domain 39C (ENSG00000168234), score: 0.64 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.72 TXNDC15thioredoxin domain containing 15 (ENSG00000113621), score: 0.65 USP20ubiquitin specific peptidase 20 (ENSG00000136878), score: -0.73 XKR9XK, Kell blood group complex subunit-related family, member 9 (ENSG00000221947), score: 0.91 ZAP70zeta-chain (TCR) associated protein kinase 70kDa (ENSG00000115085), score: 0.64 ZC3H12Dzinc finger CCCH-type containing 12D (ENSG00000178199), score: 0.75 ZMPSTE24zinc metallopeptidase (STE24 homolog, S. cerevisiae) (ENSG00000084073), score: 0.57 ZNF750zinc finger protein 750 (ENSG00000141579), score: 0.76

Non-Entrez genes

Unknown, score:

Help | Hide | Top Conditions

Id species tissue sex individual
oan_lv_f_ca1 oan lv f _
oan_lv_m_ca1 oan lv m _
mmu_lv_m1_ca1 mmu lv m 1
mmu_lv_f_ca1 mmu lv f _
mmu_lv_m2_ca1 mmu lv m 2

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