Previous module | Next module Module #265, TG: 2.4, TC: 2.6, 88 probes, 88 Entrez genes, 4 conditions

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Expression data for module #265

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

neurological system process

A organ system process carried out by any of the organs or tissues of neurological system.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

sensory perception

The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.

sensory perception of chemical stimulus

The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.

sensory perception of taste

The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

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NA

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

Help | Hide | Top The GO tree — Cellular Components

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plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

cation channel complex

An ion channel complex through which cations pass.

sodium channel complex

An ion channel complex through which sodium ions pass.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

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NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

Help | Hide | Top The GO tree — Molecular Function

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protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

sodium channel activity

Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

amiloride-sensitive sodium channel activity

NA

protein domain specific binding

Interacting selectively and non-covalently with a specific domain of a protein.

passive transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.

ligand-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

WW domain binding

Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

amiloride-sensitive sodium channel activity

NA

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04960 2.732e-04 0.2413 5
16 Aldosterone-regulated sodium reabsorption
04742 1.736e-02 0.1508 3
10 Taste transduction

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ACOT11acyl-CoA thioesterase 11 (ENSG00000162390), score: 0.67 ACPPacid phosphatase, prostate (ENSG00000014257), score: 0.88 AQP3aquaporin 3 (Gill blood group) (ENSG00000165272), score: 0.68 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.63 BARX2BARX homeobox 2 (ENSG00000043039), score: 0.73 BDKRB2bradykinin receptor B2 (ENSG00000168398), score: 0.63 C18orf1chromosome 18 open reading frame 1 (ENSG00000168675), score: -0.58 C19orf28chromosome 19 open reading frame 28 (ENSG00000161091), score: 0.64 C4orf31chromosome 4 open reading frame 31 (ENSG00000173376), score: 0.62 CA12carbonic anhydrase XII (ENSG00000074410), score: 0.73 CASRcalcium-sensing receptor (ENSG00000036828), score: 0.63 CCNT2cyclin T2 (ENSG00000082258), score: -0.65 CELcarboxyl ester lipase (bile salt-stimulated lipase) (ENSG00000170835), score: 0.69 CLDN16claudin 16 (ENSG00000113946), score: 0.62 CRYAAcrystallin, alpha A (ENSG00000160202), score: 0.94 CTSHcathepsin H (ENSG00000103811), score: 0.62 CUBNcubilin (intrinsic factor-cobalamin receptor) (ENSG00000107611), score: 0.63 DDCdopa decarboxylase (aromatic L-amino acid decarboxylase) (ENSG00000132437), score: 0.65 DPEP1dipeptidase 1 (renal) (ENSG00000015413), score: 0.67 ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific ) (ENSG00000163435), score: 0.65 ELF5E74-like factor 5 (ets domain transcription factor) (ENSG00000135374), score: 0.79 F2RL1coagulation factor II (thrombin) receptor-like 1 (ENSG00000164251), score: 0.65 FAM150Bfamily with sequence similarity 150, member B (ENSG00000189292), score: 0.76 FOXI1forkhead box I1 (ENSG00000168269), score: 0.71 GATA3GATA binding protein 3 (ENSG00000107485), score: 0.67 GCNT3glucosaminyl (N-acetyl) transferase 3, mucin type (ENSG00000140297), score: 0.72 GPR114G protein-coupled receptor 114 (ENSG00000159618), score: 1 GRHL2grainyhead-like 2 (Drosophila) (ENSG00000083307), score: 0.64 HOXA10homeobox A10 (ENSG00000153807), score: 0.66 HOXD10homeobox D10 (ENSG00000128710), score: 0.61 HOXD4homeobox D4 (ENSG00000170166), score: 0.64 HSD11B2hydroxysteroid (11-beta) dehydrogenase 2 (ENSG00000176387), score: 0.66 IGF2BP1insulin-like growth factor 2 mRNA binding protein 1 (ENSG00000159217), score: 0.71 IL1RL1interleukin 1 receptor-like 1 (ENSG00000115602), score: 0.83 ILDR1immunoglobulin-like domain containing receptor 1 (ENSG00000145103), score: 0.66 IMPA2inositol(myo)-1(or 4)-monophosphatase 2 (ENSG00000141401), score: 0.69 KCNE3potassium voltage-gated channel, Isk-related family, member 3 (ENSG00000175538), score: 0.71 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.72 KCNK5potassium channel, subfamily K, member 5 (ENSG00000164626), score: 0.67 KIF13Bkinesin family member 13B (ENSG00000197892), score: 0.61 LGALS2lectin, galactoside-binding, soluble, 2 (ENSG00000100079), score: 0.69 LMX1BLIM homeobox transcription factor 1, beta (ENSG00000136944), score: 0.85 MMP7matrix metallopeptidase 7 (matrilysin, uterine) (ENSG00000137673), score: 0.88 NOX4NADPH oxidase 4 (ENSG00000086991), score: 0.71 NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin) (ENSG00000116218), score: 0.8 OLFM4olfactomedin 4 (ENSG00000102837), score: 0.64 OVCH2ovochymase 2 (gene/pseudogene) (ENSG00000183378), score: 0.77 PABPC1Lpoly(A) binding protein, cytoplasmic 1-like (ENSG00000101104), score: 0.67 PAPPApregnancy-associated plasma protein A, pappalysin 1 (ENSG00000182752), score: 0.65 PAPPA2pappalysin 2 (ENSG00000116183), score: 0.98 PEPDpeptidase D (ENSG00000124299), score: 0.73 PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific) (ENSG00000197943), score: 0.67 PLEKHJ1pleckstrin homology domain containing, family J member 1 (ENSG00000104886), score: 0.76 PNPLA1patatin-like phospholipase domain containing 1 (ENSG00000180316), score: 0.62 PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit (ENSG00000111725), score: 0.69 PROM2prominin 2 (ENSG00000155066), score: 0.75 PTPN1protein tyrosine phosphatase, non-receptor type 1 (ENSG00000196396), score: 0.62 QARSglutaminyl-tRNA synthetase (ENSG00000172053), score: 0.66 RAB17RAB17, member RAS oncogene family (ENSG00000124839), score: 0.66 RB1CC1RB1-inducible coiled-coil 1 (ENSG00000023287), score: -0.58 RHCGRh family, C glycoprotein (ENSG00000140519), score: 0.7 RNF152ring finger protein 152 (ENSG00000176641), score: 0.62 SCNN1Asodium channel, nonvoltage-gated 1 alpha (ENSG00000111319), score: 0.68 SCNN1Bsodium channel, nonvoltage-gated 1, beta (ENSG00000168447), score: 0.74 SCNN1Gsodium channel, nonvoltage-gated 1, gamma (ENSG00000166828), score: 0.69 SIM2single-minded homolog 2 (Drosophila) (ENSG00000159263), score: 0.7 SLC15A1solute carrier family 15 (oligopeptide transporter), member 1 (ENSG00000088386), score: 0.71 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 0.63 SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12 (ENSG00000148942), score: 0.7 SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19 (ENSG00000174358), score: 0.72 SLC7A9solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 (ENSG00000021488), score: 0.65 SLC9A4solute carrier family 9 (sodium/hydrogen exchanger), member 4 (ENSG00000180251), score: 0.76 STK32Bserine/threonine kinase 32B (ENSG00000152953), score: 0.67 SUSD2sushi domain containing 2 (ENSG00000099994), score: 0.73 TBC1D1TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (ENSG00000065882), score: 0.63 TBX2T-box 2 (ENSG00000121068), score: 0.63 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.73 TM7SF3transmembrane 7 superfamily member 3 (ENSG00000064115), score: 0.63 TMPRSS2transmembrane protease, serine 2 (ENSG00000184012), score: 0.63 TMPRSS4transmembrane protease, serine 4 (ENSG00000137648), score: 0.87 TNRC6Ctrinucleotide repeat containing 6C (ENSG00000078687), score: -0.59 TRPV4transient receptor potential cation channel, subfamily V, member 4 (ENSG00000111199), score: 0.68 WDR1WD repeat domain 1 (ENSG00000071127), score: 0.63 WDR72WD repeat domain 72 (ENSG00000166415), score: 0.75 WDR91WD repeat domain 91 (ENSG00000105875), score: 0.62 WNT8Bwingless-type MMTV integration site family, member 8B (ENSG00000075290), score: 0.65 XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (ENSG00000122121), score: 0.73 ZBTB6zinc finger and BTB domain containing 6 (ENSG00000186130), score: -0.59

Non-Entrez genes

Unknown, score:

Help | Hide | Top Conditions

Id species tissue sex individual
ppa_kd_f_ca1 ppa kd f _
hsa_kd_f_ca1 hsa kd f _
hsa_kd_m2_ca1 hsa kd m 2
hsa_kd_m1_ca1 hsa kd m 1

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