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Expression data for module #271

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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reproduction

The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism.

chromosome segregation

The process by which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets.

chromosome organization

A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information.

mitotic sister chromatid segregation

The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.

cell cycle checkpoint

The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

mitotic cell cycle

Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.

M phase

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.

nuclear division

A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

reproductive developmental process

A developmental process by which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.

signal transduction

The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

DNA metabolic process

Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

DNA recombination

Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

organelle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

microtubule-based process

Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.

microtubule-based movement

Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

mitotic spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

meiosis

A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiotic division occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations.

meiosis I

A cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.

synapsis

The cell cycle process whereby the side by side pairing and physical juxtaposition of homologous chromosomes is created at the metaphase plate.

reciprocal meiotic recombination

The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.

gamete generation

The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.

germ cell development

The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.

spermatogenesis

The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

fertilization

The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

gene expression

The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

regulation of cell cycle process

Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of gene expression

Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

cellular component organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.

RNA metabolic process

The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

gene silencing

Any transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

sexual reproduction

The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

reproductive process

A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

signaling

The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.

signal transmission

The process whereby a signal is released and/or conveyed from one location to another.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

gene silencing by RNA

Any process by which RNA molecules inactivate expression of target genes.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

multicellular organism reproduction

The biological process by which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

regulation of organelle organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.

piRNA metabolic process

The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

ncRNA metabolic process

The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs).

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

male gamete generation

Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction.

organelle fission

The creation of two or more organelles by division of one organelle.

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

reproductive process in a multicellular organism

The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.

reproductive cellular process

A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cellular component organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cell division

The process resulting in the physical partitioning and separation of a cell into daughter cells.

meiotic cell cycle

Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell.

M phase of meiotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the meiotic cell cycle during which meiosis takes place.

regulation of nuclear division

Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

chromosome organization involved in meiosis

A process of chromosome organization that is involved in meiosis.

nucleic acid metabolic process

Any cellular metabolic process involving nucleic acids.

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reproductive process

A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

organelle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

reproductive cellular process

A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism.

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

multicellular organism reproduction

The biological process by which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

reproductive process in a multicellular organism

The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.

reproductive developmental process

A developmental process by which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cellular component organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

fertilization

The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).

reproductive process in a multicellular organism

The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

regulation of organelle organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.

regulation of organelle organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.

germ cell development

The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.

gamete generation

The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.

signal transduction

The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell.

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

germ cell development

The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

negative regulation of gene expression

Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

chromosome organization involved in meiosis

A process of chromosome organization that is involved in meiosis.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

mitotic spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

regulation of cell cycle process

Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

germ cell development

The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.

gene silencing

Any transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation.

negative regulation of gene expression

Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

DNA metabolic process

Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

RNA metabolic process

The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

regulation of nuclear division

Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.

mitotic spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

meiosis

A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiotic division occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

M phase of meiotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the meiotic cell cycle during which meiosis takes place.

mitotic sister chromatid segregation

The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

meiosis I

A cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.

chromosome organization involved in meiosis

A process of chromosome organization that is involved in meiosis.

synapsis

The cell cycle process whereby the side by side pairing and physical juxtaposition of homologous chromosomes is created at the metaphase plate.

reciprocal meiotic recombination

The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.

reciprocal meiotic recombination

The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.

Help | Hide | Top The GO tree — Cellular Components

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nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

condensed nuclear chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus.

condensed chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosome, centromeric region

The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

ribonucleoprotein complex

A macromolecular complex containing both protein and RNA molecules.

axoneme

The bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

chromosome

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

microtubule organizing center

A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

microtubule associated complex

Any multimeric complex connected to a microtubule.

spindle microtubule

Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

Ndc80 complex

A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

chromatoid body

A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

P granule

A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

pole plasm

Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo.

germ plasm

Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line.

pi-body

A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes.

piP-body

A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

ribonucleoprotein complex

A macromolecular complex containing both protein and RNA molecules.

axoneme

The bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

axoneme

The bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements.

Ndc80 complex

A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore.

axoneme

The bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

Ndc80 complex

A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

microtubule associated complex

Any multimeric complex connected to a microtubule.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

microtubule organizing center

A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

P granule

A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

spindle microtubule

Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensed nuclear chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

microtubule organizing center

A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

microtubule associated complex

Any multimeric complex connected to a microtubule.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

P granule

A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.

Help | Hide | Top The GO tree — Molecular Function

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nucleotide binding

Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.

nucleoside binding

Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.

purine nucleoside binding

Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

motor activity

Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate.

microtubule motor activity

Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

nucleoside-triphosphatase activity

Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

pyrophosphatase activity

Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

hydrolase activity, acting on acid anhydrides

Catalysis of the hydrolysis of any acid anhydride.

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.

purine nucleotide binding

Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate.

adenyl nucleotide binding

Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.

ribonucleotide binding

Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

purine ribonucleotide binding

Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

adenyl ribonucleotide binding

Interacting selectively and non-covalently with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

all

NA

purine ribonucleotide binding

Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

adenyl nucleotide binding

Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.

adenyl ribonucleotide binding

Interacting selectively and non-covalently with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04110 2.854e-04 0.4439 6
46 Cell cycle
04114 1.930e-02 0.3764 4
39 Oocyte meiosis

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ADAD1adenosine deaminase domain containing 1 (testis-specific) (ENSG00000164113), score: 0.89 AGBL3ATP/GTP binding protein-like 3 (ENSG00000146856), score: 0.96 AK7adenylate kinase 7 (ENSG00000140057), score: 0.91 ANKRD5ankyrin repeat domain 5 (ENSG00000132623), score: 0.88 ANUBL1AN1, ubiquitin-like, homolog (Xenopus laevis) (ENSG00000172671), score: 0.8 ARID2AT rich interactive domain 2 (ARID, RFX-like) (ENSG00000189079), score: 0.81 ARMC3armadillo repeat containing 3 (ENSG00000165309), score: 0.79 ARMC4armadillo repeat containing 4 (ENSG00000169126), score: 0.86 ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila) (ENSG00000066279), score: 0.9 AURKAaurora kinase A (ENSG00000087586), score: 0.82 BAZ1Abromodomain adjacent to zinc finger domain, 1A (ENSG00000198604), score: 0.78 BOLLbol, boule-like (Drosophila) (ENSG00000152430), score: 0.87 BUB1budding uninhibited by benzimidazoles 1 homolog (yeast) (ENSG00000169679), score: 0.82 BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast) (ENSG00000156970), score: 0.8 C11orf70chromosome 11 open reading frame 70 (ENSG00000137691), score: 0.8 C12orf50chromosome 12 open reading frame 50 (ENSG00000165805), score: 0.92 C12orf63chromosome 12 open reading frame 63 (ENSG00000188596), score: 0.95 C13orf34chromosome 13 open reading frame 34 (ENSG00000136122), score: 0.91 C14orf166Bchromosome 14 open reading frame 166B (ENSG00000100565), score: 0.94 C14orf39chromosome 14 open reading frame 39 (ENSG00000179008), score: 0.85 C14orf50chromosome 14 open reading frame 50 (ENSG00000165807), score: 0.89 C15orf26chromosome 15 open reading frame 26 (ENSG00000156206), score: 0.94 C17orf104chromosome 17 open reading frame 104 (ENSG00000180336), score: 0.9 C19orf45chromosome 19 open reading frame 45 (ENSG00000198723), score: 0.86 C1orf100chromosome 1 open reading frame 100 (ENSG00000173728), score: 0.89 C1orf111chromosome 1 open reading frame 111 (ENSG00000171722), score: 0.79 C1orf158chromosome 1 open reading frame 158 (ENSG00000157330), score: 0.91 C1orf9chromosome 1 open reading frame 9 (ENSG00000094975), score: 0.85 C20orf85chromosome 20 open reading frame 85 (ENSG00000124237), score: 0.9 C4orf47chromosome 4 open reading frame 47 (ENSG00000205129), score: 0.83 C6orf204chromosome 6 open reading frame 204 (ENSG00000111860), score: 0.82 C7orf31chromosome 7 open reading frame 31 (ENSG00000153790), score: 0.78 C7orf45chromosome 7 open reading frame 45 (ENSG00000165120), score: 0.95 C7orf62chromosome 7 open reading frame 62 (ENSG00000164645), score: 0.88 C9orf96chromosome 9 open reading frame 96 (ENSG00000198870), score: 0.82 C9orf98chromosome 9 open reading frame 98 (ENSG00000165695), score: 0.83 CASC1cancer susceptibility candidate 1 (ENSG00000118307), score: 0.81 CCDC108coiled-coil domain containing 108 (ENSG00000181378), score: 0.92 CCDC135coiled-coil domain containing 135 (ENSG00000159625), score: 0.86 CCDC146coiled-coil domain containing 146 (ENSG00000135205), score: 0.81 CCDC27coiled-coil domain containing 27 (ENSG00000162592), score: 0.93 CCDC37coiled-coil domain containing 37 (ENSG00000163885), score: 0.92 CCDC40coiled-coil domain containing 40 (ENSG00000141519), score: 0.79 CCDC63coiled-coil domain containing 63 (ENSG00000173093), score: 0.94 CCDC67coiled-coil domain containing 67 (ENSG00000165325), score: 0.97 CCDC83coiled-coil domain containing 83 (ENSG00000150676), score: 0.92 CCNA1cyclin A1 (ENSG00000133101), score: 0.78 CENPFcentromere protein F, 350/400kDa (mitosin) (ENSG00000117724), score: 0.83 CENPKcentromere protein K (ENSG00000123219), score: 0.87 CEP152centrosomal protein 152kDa (ENSG00000103995), score: 0.86 CEP55centrosomal protein 55kDa (ENSG00000138180), score: 0.88 CNOT4CCR4-NOT transcription complex, subunit 4 (ENSG00000080802), score: 0.83 CPEB2cytoplasmic polyadenylation element binding protein 2 (ENSG00000137449), score: 0.81 CUL3cullin 3 (ENSG00000036257), score: 0.78 CXorf22chromosome X open reading frame 22 (ENSG00000165164), score: 0.93 CXorf30chromosome X open reading frame 30 (ENSG00000205081), score: 0.88 DDX4DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 (ENSG00000152670), score: 0.89 DMC1DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) (ENSG00000100206), score: 0.81 DNAH8dynein, axonemal, heavy chain 8 (ENSG00000124721), score: 0.94 DNAI1dynein, axonemal, intermediate chain 1 (ENSG00000122735), score: 0.82 DNAI2dynein, axonemal, intermediate chain 2 (ENSG00000171595), score: 0.85 DNAJC5BDnaJ (Hsp40) homolog, subfamily C, member 5 beta (ENSG00000147570), score: 0.78 DTLdenticleless homolog (Drosophila) (ENSG00000143476), score: 0.81 DYDC1DPY30 domain containing 1 (ENSG00000170788), score: 0.84 E2F8E2F transcription factor 8 (ENSG00000129173), score: 0.85 EFCAB1EF-hand calcium binding domain 1 (ENSG00000034239), score: 0.83 EFCAB5EF-hand calcium binding domain 5 (ENSG00000176927), score: 0.94 EFHC1EF-hand domain (C-terminal) containing 1 (ENSG00000096093), score: 0.79 ENO4enolase family member 4 (ENSG00000188316), score: 0.84 FAM194Afamily with sequence similarity 194, member A (ENSG00000163645), score: 0.89 FAM54Afamily with sequence similarity 54, member A (ENSG00000146410), score: 0.81 FAM81Bfamily with sequence similarity 81, member B (ENSG00000153347), score: 0.84 FBXO43F-box protein 43 (ENSG00000156509), score: 0.9 FBXO47F-box protein 47 (ENSG00000204952), score: 0.85 GDPD4glycerophosphodiester phosphodiesterase domain containing 4 (ENSG00000178795), score: 0.81 HORMAD1HORMA domain containing 1 (ENSG00000143452), score: 0.89 HORMAD2HORMA domain containing 2 (ENSG00000176635), score: 0.86 IQCHIQ motif containing H (ENSG00000103599), score: 0.92 IQUBIQ motif and ubiquitin domain containing (ENSG00000164675), score: 0.87 KIAA0586KIAA0586 (ENSG00000100578), score: 0.82 KIF11kinesin family member 11 (ENSG00000138160), score: 0.85 KIF14kinesin family member 14 (ENSG00000118193), score: 0.96 KIF18Akinesin family member 18A (ENSG00000121621), score: 0.91 KIF18Bkinesin family member 18B (ENSG00000186185), score: 0.9 KIF23kinesin family member 23 (ENSG00000137807), score: 0.8 KIF24kinesin family member 24 (ENSG00000186638), score: 0.88 KIF27kinesin family member 27 (ENSG00000165115), score: 0.9 KIF2Bkinesin family member 2B (ENSG00000141200), score: 0.95 KIF6kinesin family member 6 (ENSG00000164627), score: 0.83 KLHL10kelch-like 10 (Drosophila) (ENSG00000161594), score: 0.94 KNTC1kinetochore associated 1 (ENSG00000184445), score: 0.85 LHCGRluteinizing hormone/choriogonadotropin receptor (ENSG00000138039), score: 0.83 LIN28Blin-28 homolog B (C. elegans) (ENSG00000187772), score: 0.8 LRGUKleucine-rich repeats and guanylate kinase domain containing (ENSG00000155530), score: 0.86 LRP2BPLRP2 binding protein (ENSG00000109771), score: 0.79 LRRC18leucine rich repeat containing 18 (ENSG00000165383), score: 0.87 LRRC43leucine rich repeat containing 43 (ENSG00000158113), score: 0.83 LRRC50leucine rich repeat containing 50 (ENSG00000154099), score: 0.78 LRRC52leucine rich repeat containing 52 (ENSG00000162763), score: 0.88 LRRC67leucine rich repeat containing 67 (ENSG00000178125), score: 0.96 LRRIQ1leucine-rich repeats and IQ motif containing 1 (ENSG00000133640), score: 0.83 LRRIQ4leucine-rich repeats and IQ motif containing 4 (ENSG00000188306), score: 1 MAELmaelstrom homolog (Drosophila) (ENSG00000143194), score: 0.81 MAKmale germ cell-associated kinase (ENSG00000111837), score: 0.81 MELKmaternal embryonic leucine zipper kinase (ENSG00000165304), score: 0.86 MORN3MORN repeat containing 3 (ENSG00000139714), score: 0.85 MTF1metal-regulatory transcription factor 1 (ENSG00000188786), score: 0.79 MYBL1v-myb myeloblastosis viral oncogene homolog (avian)-like 1 (ENSG00000185697), score: 0.92 NCAPGnon-SMC condensin I complex, subunit G (ENSG00000109805), score: 0.86 NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae) (ENSG00000080986), score: 0.81 NEK2NIMA (never in mitosis gene a)-related kinase 2 (ENSG00000117650), score: 0.84 NFIBnuclear factor I/B (ENSG00000147862), score: -0.83 NR5A1nuclear receptor subfamily 5, group A, member 1 (ENSG00000136931), score: 0.81 NRD1nardilysin (N-arginine dibasic convertase) (ENSG00000078618), score: 0.82 NUF2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) (ENSG00000143228), score: 0.87 ORC1Lorigin recognition complex, subunit 1-like (S. cerevisiae) (ENSG00000085840), score: 0.8 PIH1D2PIH1 domain containing 2 (ENSG00000150773), score: 0.82 PIWIL1piwi-like 1 (Drosophila) (ENSG00000125207), score: 0.88 RBM46RNA binding motif protein 46 (ENSG00000151962), score: 0.92 RIBC2RIB43A domain with coiled-coils 2 (ENSG00000128408), score: 0.88 RNF17ring finger protein 17 (ENSG00000132972), score: 0.91 RNF32ring finger protein 32 (ENSG00000105982), score: 0.83 ROPN1Lropporin 1-like (ENSG00000145491), score: 0.81 RSPH1radial spoke head 1 homolog (Chlamydomonas) (ENSG00000160188), score: 0.79 SHCBP1SHC SH2-domain binding protein 1 (ENSG00000171241), score: 0.89 SLC26A8solute carrier family 26, member 8 (ENSG00000112053), score: 0.83 SMC1Bstructural maintenance of chromosomes 1B (ENSG00000077935), score: 0.94 SPACA1sperm acrosome associated 1 (ENSG00000118434), score: 0.88 SPATA17spermatogenesis associated 17 (ENSG00000162814), score: 0.84 SPATA18spermatogenesis associated 18 homolog (rat) (ENSG00000163071), score: 0.9 SPATA4spermatogenesis associated 4 (ENSG00000150628), score: 0.85 SPC25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) (ENSG00000152253), score: 0.82 SPO11SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae) (ENSG00000054796), score: 0.83 STILSCL/TAL1 interrupting locus (ENSG00000123473), score: 0.81 STRA8stimulated by retinoic acid gene 8 homolog (mouse) (ENSG00000146857), score: 0.89 SYCP1synaptonemal complex protein 1 (ENSG00000198765), score: 0.92 TDRD1tudor domain containing 1 (ENSG00000095627), score: 0.86 TDRD5tudor domain containing 5 (ENSG00000162782), score: 0.91 TDRD6tudor domain containing 6 (ENSG00000180113), score: 0.83 TEKT3tektin 3 (ENSG00000125409), score: 0.93 TEKT5tektin 5 (ENSG00000153060), score: 0.82 TMC5transmembrane channel-like 5 (ENSG00000103534), score: 0.81 TOP2Atopoisomerase (DNA) II alpha 170kDa (ENSG00000131747), score: 0.9 TP53TG5TP53 target 5 (ENSG00000124251), score: 0.88 TPX2TPX2, microtubule-associated, homolog (Xenopus laevis) (ENSG00000088325), score: 0.78 TRIM36tripartite motif-containing 36 (ENSG00000152503), score: 0.8 TRIM8tripartite motif-containing 8 (ENSG00000171206), score: -0.78 TSGA14testis specific, 14 (ENSG00000106477), score: 0.81 TTC16tetratricopeptide repeat domain 16 (ENSG00000167094), score: 0.83 TTC25tetratricopeptide repeat domain 25 (ENSG00000204815), score: 0.85 TTC29tetratricopeptide repeat domain 29 (ENSG00000137473), score: 0.86 TTKTTK protein kinase (ENSG00000112742), score: 0.87 UHRF1ubiquitin-like with PHD and ring finger domains 1 (ENSG00000034063), score: 0.84 USP7ubiquitin specific peptidase 7 (herpes virus-associated) (ENSG00000187555), score: 0.78 VASH2vasohibin 2 (ENSG00000143494), score: 0.83 WDR16WD repeat domain 16 (ENSG00000166596), score: 0.81 WDR64WD repeat domain 64 (ENSG00000162843), score: 0.98 WDR78WD repeat domain 78 (ENSG00000152763), score: 0.86 ZNRF4zinc and ring finger 4 (ENSG00000105428), score: 0.93 ZPBPzona pellucida binding protein (ENSG00000042813), score: 0.84 ZPBP2zona pellucida binding protein 2 (ENSG00000186075), score: 0.89

Non-Entrez genes

ENSG00000186075Unknown, score: 0.94 ENSG00000042813Unknown, score: 0.82 ENSG00000136122Unknown, score: 0.87 ENSG00000170788Unknown, score: 0.98

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Id species tissue sex individual
mdo_ts_m1_ca1 mdo ts m 1
mdo_ts_m2_ca1 mdo ts m 2
gga_ts_m1_ca1 gga ts m 1
ptr_ts_m_ca1 ptr ts m _
oan_ts_m3_ca1 oan ts m 3
oan_ts_m1_ca1 oan ts m 1
gga_ts_m2_ca1 gga ts m 2
mml_ts_m2_ca1 mml ts m 2
mml_ts_m1_ca1 mml ts m 1
mmu_ts_m1_ca1 mmu ts m 1
mmu_ts_m2_ca1 mmu ts m 2

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© 2008-2010 Computational Biology Group, Department of Medical Genetics, University of Lausanne, Switzerland