Under-expression is coded with green,
over-expression with red color.
regulation of the force of heart contraction
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
heart morphogenesis
The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
system process
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
muscle system process
A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
circulatory system process
A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
heart process
A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
cardiac chamber development
The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.
cardiac chamber morphogenesis
The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
muscle contraction
A process whereby force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
organ morphogenesis
Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
heart development
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
muscle organ development
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
blood circulation
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
regulation of heart contraction
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
striated muscle tissue development
The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
regulation of system process
Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
cardiac muscle tissue development
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
heart contraction
The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.
muscle tissue development
The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.
muscle structure development
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
regulation of biological quality
Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
all
NA
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of system process
Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
cardiac chamber morphogenesis
The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
organ morphogenesis
Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
muscle organ development
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
heart contraction
The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.
regulation of the force of heart contraction
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
cardiac chamber morphogenesis
The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.
heart morphogenesis
The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
cardiac chamber development
The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.
muscle tissue development
The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.
regulation of heart contraction
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body.
cardiac muscle tissue development
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
contractile fiber
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
cytoplasm
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
actin cytoskeleton
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
myofibril
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
sarcomere
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
Z disc
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
A band
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
I band
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
contractile fiber part
Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
all
NA
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
A band
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
I band
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.
Z disc
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
contractile fiber
Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
contractile fiber part
Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
contractile fiber part
Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
sarcomere
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
Id | Pvalue | ExpCount | Count | Size | Term |
---|---|---|---|---|---|
04260 | 3.317e-02 | 0.4524 | 4 | 25 | Cardiac muscle contraction |
05016 | 4.950e-02 | 0.8866 | 5 | 49 | Huntington's disease |
ACAD9acyl-CoA dehydrogenase family, member 9 (ENSG00000177646), score: 0.65 AHCYL1adenosylhomocysteinase-like 1 (ENSG00000168710), score: -0.76 AIG1androgen-induced 1 (ENSG00000146416), score: -0.72 AMPD1adenosine monophosphate deaminase 1 (ENSG00000116748), score: 0.92 APOBEC2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 (ENSG00000124701), score: 0.74 ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) (ENSG00000124198), score: -0.82 ARL14ADP-ribosylation factor-like 14 (ENSG00000179674), score: 0.63 ATP1B4ATPase, Na+/K+ transporting, beta 4 polypeptide (ENSG00000101892), score: 0.74 B4GALT5UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 (ENSG00000158470), score: -0.69 BCL2L13BCL2-like 13 (apoptosis facilitator) (ENSG00000099968), score: 0.85 BEST3bestrophin 3 (ENSG00000127325), score: 0.79 BSDC1BSD domain containing 1 (ENSG00000160058), score: -0.77 C12orf45chromosome 12 open reading frame 45 (ENSG00000151131), score: 0.68 C1QTNF7C1q and tumor necrosis factor related protein 7 (ENSG00000163145), score: 0.87 CCNIcyclin I (ENSG00000118816), score: 0.69 CDCP2CUB domain containing protein 2 (ENSG00000157211), score: 0.68 CHRNA5cholinergic receptor, nicotinic, alpha 5 (ENSG00000169684), score: 0.69 CLEC3AC-type lectin domain family 3, member A (ENSG00000166509), score: 0.71 CLTAclathrin, light chain A (ENSG00000122705), score: -0.82 CMYA5cardiomyopathy associated 5 (ENSG00000164309), score: 0.75 COPS7ACOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) (ENSG00000111652), score: 0.63 CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein) (ENSG00000129170), score: 0.68 CYSLTR1cysteinyl leukotriene receptor 1 (ENSG00000173198), score: 0.65 DCAF6DDB1 and CUL4 associated factor 6 (ENSG00000143164), score: 0.72 DHCR77-dehydrocholesterol reductase (ENSG00000172893), score: -0.69 DNTTIP1deoxynucleotidyltransferase, terminal, interacting protein 1 (ENSG00000101457), score: 0.7 DSCR3Down syndrome critical region gene 3 (ENSG00000157538), score: 0.64 EDNRAendothelin receptor type A (ENSG00000151617), score: 0.7 EIF3Deukaryotic translation initiation factor 3, subunit D (ENSG00000100353), score: 0.72 F2RL2coagulation factor II (thrombin) receptor-like 2 (ENSG00000164220), score: 0.73 F8coagulation factor VIII, procoagulant component (ENSG00000185010), score: 0.7 FBP2fructose-1,6-bisphosphatase 2 (ENSG00000130957), score: 0.71 FBXO40F-box protein 40 (ENSG00000163833), score: 0.65 FGF6fibroblast growth factor 6 (ENSG00000111241), score: 0.74 FHL2four and a half LIM domains 2 (ENSG00000115641), score: 0.67 FHL3four and a half LIM domains 3 (ENSG00000183386), score: 0.8 FIGFc-fos induced growth factor (vascular endothelial growth factor D) (ENSG00000165197), score: 0.74 FILIP1filamin A interacting protein 1 (ENSG00000118407), score: 0.73 FSD2fibronectin type III and SPRY domain containing 2 (ENSG00000186628), score: 0.67 FZD2frizzled homolog 2 (Drosophila) (ENSG00000180340), score: 0.73 GATA5GATA binding protein 5 (ENSG00000130700), score: 0.84 GPR1G protein-coupled receptor 1 (ENSG00000183671), score: 0.7 HIBCH3-hydroxyisobutyryl-CoA hydrolase (ENSG00000198130), score: 0.65 HMGXB4HMG box domain containing 4 (ENSG00000100281), score: 0.69 KBTBD10kelch repeat and BTB (POZ) domain containing 10 (ENSG00000239474), score: 0.64 KCNJ2potassium inwardly-rectifying channel, subfamily J, member 2 (ENSG00000123700), score: 0.7 KIAA0907KIAA0907 (ENSG00000132680), score: 0.68 KIAA1598KIAA1598 (ENSG00000187164), score: -0.72 KLHL31kelch-like 31 (Drosophila) (ENSG00000124743), score: 0.75 LMOD2leiomodin 2 (cardiac) (ENSG00000170807), score: 0.64 LRRC10leucine rich repeat containing 10 (ENSG00000198812), score: 0.77 LRRC2leucine rich repeat containing 2 (ENSG00000163827), score: 0.68 MAK16MAK16 homolog (S. cerevisiae) (ENSG00000198042), score: 0.7 MAP3K4mitogen-activated protein kinase kinase kinase 4 (ENSG00000085511), score: 0.69 MAP7microtubule-associated protein 7 (ENSG00000135525), score: -0.78 MEOX2mesenchyme homeobox 2 (ENSG00000106511), score: 0.72 MRPL50mitochondrial ribosomal protein L50 (ENSG00000136897), score: 0.63 MRPS27mitochondrial ribosomal protein S27 (ENSG00000113048), score: 0.72 MYBPC3myosin binding protein C, cardiac (ENSG00000134571), score: 0.68 MYL3myosin, light chain 3, alkali; ventricular, skeletal, slow (ENSG00000160808), score: 0.66 MYLK3myosin light chain kinase 3 (ENSG00000140795), score: 0.69 MYOCDmyocardin (ENSG00000141052), score: 0.87 MYOTmyotilin (ENSG00000120729), score: 1 MYOZ2myozenin 2 (ENSG00000172399), score: 0.64 NDUFA12NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 (ENSG00000184752), score: 0.65 NDUFS3NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) (ENSG00000213619), score: 0.66 PDE5Aphosphodiesterase 5A, cGMP-specific (ENSG00000138735), score: 0.73 PDLIM5PDZ and LIM domain 5 (ENSG00000163110), score: 0.64 PLEKHA7pleckstrin homology domain containing, family A member 7 (ENSG00000166689), score: 0.64 PLNphospholamban (ENSG00000198523), score: 0.72 PM20D2peptidase M20 domain containing 2 (ENSG00000146281), score: 0.7 POLR2Fpolymerase (RNA) II (DNA directed) polypeptide F (ENSG00000100142), score: 0.72 PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunit (ENSG00000106617), score: 0.64 PSMA3proteasome (prosome, macropain) subunit, alpha type, 3 (ENSG00000100567), score: 0.64 PTRFpolymerase I and transcript release factor (ENSG00000177469), score: 0.68 RAB19RAB19, member RAS oncogene family (ENSG00000146955), score: 0.66 RBM20RNA binding motif protein 20 (ENSG00000203867), score: 0.67 RNF34ring finger protein 34 (ENSG00000170633), score: -0.77 SAV1salvador homolog 1 (Drosophila) (ENSG00000151748), score: 0.66 SMPXsmall muscle protein, X-linked (ENSG00000091482), score: 0.73 SMYD1SET and MYND domain containing 1 (ENSG00000115593), score: 0.74 SOD2superoxide dismutase 2, mitochondrial (ENSG00000112096), score: 0.66 ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (ENSG00000140557), score: 0.74 TBX20T-box 20 (ENSG00000164532), score: 0.73 TBX5T-box 5 (ENSG00000089225), score: 0.89 TCF12transcription factor 12 (ENSG00000140262), score: 0.76 TEAD4TEA domain family member 4 (ENSG00000197905), score: 0.73 TECRLtrans-2,3-enoyl-CoA reductase-like (ENSG00000205678), score: 0.74 TIMM10translocase of inner mitochondrial membrane 10 homolog (yeast) (ENSG00000134809), score: 0.74 TMEM60transmembrane protein 60 (ENSG00000135211), score: 0.7 TMEM9transmembrane protein 9 (ENSG00000116857), score: -0.68 TNNT2troponin T type 2 (cardiac) (ENSG00000118194), score: 0.79 TRIM55tripartite motif-containing 55 (ENSG00000147573), score: 0.87 TRIM63tripartite motif-containing 63 (ENSG00000158022), score: 0.76 UNC119unc-119 homolog (C. elegans) (ENSG00000109103), score: -0.76 UQCRC2ubiquinol-cytochrome c reductase core protein II (ENSG00000140740), score: 0.66 YIPF1Yip1 domain family, member 1 (ENSG00000058799), score: 0.64
Id | species | tissue | sex | individual |
---|---|---|---|---|
gga_ht_f_ca1 | gga | ht | f | _ |
gga_ht_m_ca1 | gga | ht | m | _ |
oan_ht_f_ca1 | oan | ht | f | _ |
oan_ht_m_ca1 | oan | ht | m | _ |