Previous module | Next module Module #294, TG: 2.4, TC: 2.4, 98 probes, 98 Entrez genes, 7 conditions

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Expression data for module #294

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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sulfur amino acid metabolic process

The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.

sulfur metabolic process

The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

cysteine metabolic process

The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.

cellular amino acid derivative metabolic process

The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

coenzyme metabolic process

The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

lipid transport

The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

hemostasis

The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

bile acid metabolic process

The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

serine family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

amine biosynthetic process

The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

lipid localization

Any process by which a lipid is transported to, or maintained in, a specific location.

organic acid transport

The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells by means of some external agent such as a transporter or pore.

organic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

carboxylic acid metabolic process

The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

monocarboxylic acid metabolic process

The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).

macromolecule localization

Any process by which a macromolecule is transported to, or maintained in, a specific location.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

homeostatic process

Any biological process involved in the maintenance of an internal steady-state.

cholesterol homeostasis

Any process involved in the maintenance of an internal steady-state of cholesterol within an organism or cell.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular nitrogen compound biosynthetic process

The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.

sulfur compound biosynthetic process

The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

small molecule biosynthetic process

The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.

carboxylic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

carboxylic acid transport

The directed movement of carboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

chemical homeostasis

Any biological process involved in the maintenance of an internal steady-state of a chemical.

coagulation

The process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

cofactor metabolic process

The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

lipid homeostasis

Any process involved in the maintenance of an internal steady-state of lipid within an organism or cell.

sterol homeostasis

Any process involved in the maintenance of an internal steady-state of sterol within an organism or cell.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

all

NA

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

small molecule biosynthetic process

The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

cellular nitrogen compound biosynthetic process

The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.

organic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.

sulfur compound biosynthetic process

The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.

organic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

lipid transport

The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

amine biosynthetic process

The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

sulfur amino acid metabolic process

The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

carboxylic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

cysteine metabolic process

The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.

bile acid metabolic process

The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

Help | Hide | Top The GO tree — Cellular Components

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intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

cell fraction

A generic term for parts of cells prepared by disruptive biochemical techniques.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

fibrinogen complex

A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

stored secretory granule

A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.

cytoplasmic membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

platelet alpha granule

A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).

platelet alpha granule lumen

The volume enclosed by the membrane of the platelet alpha granule.

cytoplasmic vesicle

A vesicle formed of membrane or protein, found in the cytoplasm of a cell.

membrane-enclosed lumen

The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

vesicle

Any small, fluid-filled, spherical organelle enclosed by membrane or protein.

vesicle lumen

The volume enclosed by the membrane or protein that forms a vesicle.

membrane-bounded vesicle

Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

cytoplasmic vesicle part

Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

all

NA

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

fibrinogen complex

A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.

cytoplasmic vesicle

A vesicle formed of membrane or protein, found in the cytoplasm of a cell.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

fibrinogen complex

A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

cytoplasmic vesicle part

Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.

cytoplasmic membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

vesicle lumen

The volume enclosed by the membrane or protein that forms a vesicle.

cytoplasmic membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

cytoplasmic vesicle

A vesicle formed of membrane or protein, found in the cytoplasm of a cell.

cytoplasmic vesicle part

Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

platelet alpha granule lumen

The volume enclosed by the membrane of the platelet alpha granule.

Help | Hide | Top The GO tree — Molecular Function

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molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

carboxylesterase activity

Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion.

enzyme inhibitor activity

Stops, prevents or reduces the activity of an enzyme.

endopeptidase inhibitor activity

Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

lipid transporter activity

Enables the directed movement of lipids into, out of, within or between cells.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

metal ion binding

Interacting selectively and non-covalently with any metal ion.

iron ion binding

Interacting selectively and non-covalently with iron (Fe) ions.

lipid binding

Interacting selectively and non-covalently with a lipid.

endopeptidase regulator activity

Modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

sterol transporter activity

Enables the directed movement of sterols into, out of, within or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

amino acid binding

Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

hydrolase activity, acting on ester bonds

Catalysis of the hydrolysis of any ester bond.

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

vitamin binding

Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

heme binding

Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

enzyme regulator activity

Modulates the activity of an enzyme.

carboxylic acid binding

Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

monocarboxylic acid binding

Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-).

ion binding

Interacting selectively and non-covalently with ions, charged atoms or groups of atoms.

cation binding

Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge.

amine binding

Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.

tetrapyrrole binding

Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position.

transition metal ion binding

Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

cofactor binding

Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

peptidase regulator activity

Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

vitamin B6 binding

Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.

all

NA

amino acid binding

Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

endopeptidase inhibitor activity

Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

heme binding

Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04610 2.373e-05 0.684 8
21 Complement and coagulation cascades
00120 2.733e-03 0.09771 3
3 Primary bile acid biosynthesis
00270 1.504e-02 0.3583 4
11 Cysteine and methionine metabolism
02010 3.151e-02 0.456 4
14 ABC transporters

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ABCA1ATP-binding cassette, sub-family A (ABC1), member 1 (ENSG00000165029), score: 0.75 ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ENSG00000073734), score: 0.72 ABCD3ATP-binding cassette, sub-family D (ALD), member 3 (ENSG00000117528), score: 0.77 ABCG5ATP-binding cassette, sub-family G (WHITE), member 5 (ENSG00000138075), score: 0.63 ACBD5acyl-CoA binding domain containing 5 (ENSG00000107897), score: 0.68 ACOT12acyl-CoA thioesterase 12 (ENSG00000172497), score: 0.75 ACSL5acyl-CoA synthetase long-chain family member 5 (ENSG00000197142), score: 0.69 AGXTalanine-glyoxylate aminotransferase (ENSG00000172482), score: 0.63 AK2adenylate kinase 2 (ENSG00000004455), score: 0.65 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.69 ALBalbumin (ENSG00000163631), score: 0.68 AMBPalpha-1-microglobulin/bikunin precursor (ENSG00000106927), score: 0.63 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.69 AQP8aquaporin 8 (ENSG00000103375), score: 0.61 ARCN1archain 1 (ENSG00000095139), score: 0.62 ATL2atlastin GTPase 2 (ENSG00000119787), score: 0.61 ATP8B1ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ENSG00000081923), score: 0.61 AVPR1Aarginine vasopressin receptor 1A (ENSG00000166148), score: 0.78 BBS2Bardet-Biedl syndrome 2 (ENSG00000125124), score: -0.76 BMP2bone morphogenetic protein 2 (ENSG00000125845), score: 0.64 C5complement component 5 (ENSG00000106804), score: 0.74 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.67 CCBL2cysteine conjugate-beta lyase 2 (ENSG00000137944), score: 0.62 CCDC92coiled-coil domain containing 92 (ENSG00000119242), score: -0.73 CDO1cysteine dioxygenase, type I (ENSG00000129596), score: 0.63 CNR2cannabinoid receptor 2 (macrophage) (ENSG00000188822), score: 0.87 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.68 CREB3L3cAMP responsive element binding protein 3-like 3 (ENSG00000060566), score: 0.65 CTHcystathionase (cystathionine gamma-lyase) (ENSG00000116761), score: 0.65 CYP39A1cytochrome P450, family 39, subfamily A, polypeptide 1 (ENSG00000146233), score: 0.74 CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1 (ENSG00000172817), score: 0.72 DERL1Der1-like domain family, member 1 (ENSG00000136986), score: 0.67 DNAJC22DnaJ (Hsp40) homolog, subfamily C, member 22 (ENSG00000178401), score: 0.63 EGFRepidermal growth factor receptor (ENSG00000146648), score: 0.74 ERN1endoplasmic reticulum to nucleus signaling 1 (ENSG00000178607), score: 0.63 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.66 F9coagulation factor IX (ENSG00000101981), score: 0.68 FABP2fatty acid binding protein 2, intestinal (ENSG00000145384), score: 0.79 FETUBfetuin B (ENSG00000090512), score: 0.86 FGBfibrinogen beta chain (ENSG00000171564), score: 0.61 FGGfibrinogen gamma chain (ENSG00000171557), score: 0.63 FN1fibronectin 1 (ENSG00000115414), score: 0.67 GCH1GTP cyclohydrolase 1 (ENSG00000131979), score: 0.64 GCLMglutamate-cysteine ligase, modifier subunit (ENSG00000023909), score: 0.67 GNMTglycine N-methyltransferase (ENSG00000124713), score: 0.76 GPLD1glycosylphosphatidylinositol specific phospholipase D1 (ENSG00000112293), score: 0.77 H6PDhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (ENSG00000049239), score: 0.67 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.88 HAO1hydroxyacid oxidase (glycolate oxidase) 1 (ENSG00000101323), score: 0.66 HEBP1heme binding protein 1 (ENSG00000013583), score: 0.65 HGFhepatocyte growth factor (hepapoietin A; scatter factor) (ENSG00000019991), score: 0.64 HPXhemopexin (ENSG00000110169), score: 0.64 HTRA1HtrA serine peptidase 1 (ENSG00000166033), score: -0.72 IGF1insulin-like growth factor 1 (somatomedin C) (ENSG00000017427), score: 0.68 IYDiodotyrosine deiodinase (ENSG00000009765), score: 0.76 KLBklotho beta (ENSG00000134962), score: 0.64 LECT2leukocyte cell-derived chemotaxin 2 (ENSG00000145826), score: 0.87 LIPClipase, hepatic (ENSG00000166035), score: 0.67 LPIN2lipin 2 (ENSG00000101577), score: 0.63 MAT1Amethionine adenosyltransferase I, alpha (ENSG00000151224), score: 0.72 MTTPmicrosomal triglyceride transfer protein (ENSG00000138823), score: 0.68 NPC1Niemann-Pick disease, type C1 (ENSG00000141458), score: 0.71 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.68 ONECUT1one cut homeobox 1 (ENSG00000169856), score: 0.71 OTCornithine carbamoyltransferase (ENSG00000036473), score: 0.88 P4HTMprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) (ENSG00000178467), score: -0.81 PAFAH2platelet-activating factor acetylhydrolase 2, 40kDa (ENSG00000158006), score: 0.63 PANK1pantothenate kinase 1 (ENSG00000152782), score: 0.65 PEX11Aperoxisomal biogenesis factor 11 alpha (ENSG00000166821), score: 0.76 PLA2G12Bphospholipase A2, group XIIB (ENSG00000138308), score: 0.63 PM20D1peptidase M20 domain containing 1 (ENSG00000162877), score: 0.63 PROZprotein Z, vitamin K-dependent plasma glycoprotein (ENSG00000126231), score: 0.67 PSEN2presenilin 2 (Alzheimer disease 4) (ENSG00000143801), score: 0.71 PYGLphosphorylase, glycogen, liver (ENSG00000100504), score: 0.62 SDR42E1short chain dehydrogenase/reductase family 42E, member 1 (ENSG00000184860), score: 0.73 SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (ENSG00000140093), score: 0.69 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.69 SLC16A10solute carrier family 16, member 10 (aromatic amino acid transporter) (ENSG00000112394), score: 0.74 SLC17A8solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 (ENSG00000179520), score: 0.72 SLC25A47solute carrier family 25, member 47 (ENSG00000140107), score: 0.72 SLC2A9solute carrier family 2 (facilitated glucose transporter), member 9 (ENSG00000109667), score: 0.69 SLC30A7solute carrier family 30 (zinc transporter), member 7 (ENSG00000162695), score: 0.61 SLC35D1solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 (ENSG00000116704), score: 0.62 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.79 SLC46A1solute carrier family 46 (folate transporter), member 1 (ENSG00000076351), score: 0.62 SLC7A2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (ENSG00000003989), score: 0.77 SLC7A6solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (ENSG00000103064), score: -0.88 SPP2secreted phosphoprotein 2, 24kDa (ENSG00000072080), score: 0.7 STARD5StAR-related lipid transfer (START) domain containing 5 (ENSG00000172345), score: 0.8 TATtyrosine aminotransferase (ENSG00000198650), score: 0.78 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.76 TMEM135transmembrane protein 135 (ENSG00000166575), score: 0.75 TMEM20transmembrane protein 20 (ENSG00000176273), score: 0.65 TTC36tetratricopeptide repeat domain 36 (ENSG00000172425), score: 0.61 TTC39Ctetratricopeptide repeat domain 39C (ENSG00000168234), score: 0.63 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.77 USO1USO1 vesicle docking protein homolog (yeast) (ENSG00000138768), score: 0.61 XKR9XK, Kell blood group complex subunit-related family, member 9 (ENSG00000221947), score: 1

Non-Entrez genes

Unknown, score:

Help | Hide | Top Conditions

Id species tissue sex individual
mdo_lv_f_ca1 mdo lv f _
oan_lv_f_ca1 oan lv f _
oan_lv_m_ca1 oan lv m _
mmu_lv_m1_ca1 mmu lv m 1
mdo_lv_m_ca1 mdo lv m _
mmu_lv_f_ca1 mmu lv f _
mmu_lv_m2_ca1 mmu lv m 2

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