Previous module | Next module Module #300, TG: 2.4, TC: 2.2, 121 probes, 121 Entrez genes, 9 conditions

Help | Hide | Top Help | Show | Top Expression data

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

all

NA

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell fraction

A generic term for parts of cells prepared by disruptive biochemical techniques.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

membrane fraction

That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes.

insoluble fraction

That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water.

brush border

Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

cation channel complex

An ion channel complex through which cations pass.

sodium channel complex

An ion channel complex through which sodium ions pass.

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

metal ion transmembrane transporter activity

Catalysis of the transfer of metal ions from one side of a membrane to the other.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

sodium channel activity

Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

secondary active transmembrane transporter activity

Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

monovalent inorganic cation transmembrane transporter activity

Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

sodium ion transmembrane transporter activity

Catalysis of the transfer of sodium ions (Na+) from one side of a membrane to the other.

organic cation transmembrane transporter activity

Catalysis of the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.

channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

amiloride-sensitive sodium channel activity

NA

symporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

passive transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.

active transmembrane transporter activity

Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.

ligand-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

inorganic cation transmembrane transporter activity

Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

amiloride-sensitive sodium channel activity

NA

sodium ion transmembrane transporter activity

Catalysis of the transfer of sodium ions (Na+) from one side of a membrane to the other.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0006814	1.730e-07	1.064	12 SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC22A4, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9	47	sodium ion transport
GO:0007588	6.065e-07	0.5434	9 AQP3, ATP6V0A4, CLCN5, CLDN16, DAB2, KCNJ1, SCNN1A, SCNN1B, SCNN1G	24	excretion
GO:0006812	1.678e-06	5.162	22 ATP6V0A4, ATP7A, EGF, KCNJ1, KCNJ16, PKD2, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC22A4, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, TCN2, TRPM6	228	cation transport
GO:0006811	3.764e-06	7.516	26 ATP6V0A4, ATP7A, CLCN5, CLDN16, CLIC6, EGF, KCNJ1, KCNJ16, PKD2, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC22A4, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, TCN2, TRPM6, WNK1	332	ion transport
GO:0015672	6.816e-06	2.536	15 ATP6V0A4, KCNJ1, KCNJ16, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC22A4, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9	112	monovalent inorganic cation transport
GO:0030001	1.793e-05	4.505	19 ATP7A, EGF, KCNJ1, KCNJ16, PKD2, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC22A4, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, TCN2, TRPM6	199	metal ion transport
GO:0055085	1.267e-04	6.294	21 AQP3, ATP6V0A4, ATP7A, CLCN5, EGF, PKD2, RHAG, RHCG, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC18A1, SLC22A4, SLC25A48, SLC5A11, SLC5A12, SLC5A9, SLC7A9, TRPM6	278	transmembrane transport
GO:0051234	6.898e-04	24.52	45 AP1G1, AP1S3, AQP3, ARSB, ATP6V0A4, ATP7A, CLCN5, CLDN16, CLIC6, CLU, CUBN, DAB2, DPP4, EGF, FAM3D, KCNJ1, KCNJ16, PKD2, PRLR, RAB19, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC18A1, SLC22A4, SLC25A48, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, TCN2, TRPM6, UPK3A, WNK1	1083	establishment of localization
GO:0006810	1.181e-03	24.25	44 AP1G1, AP1S3, AQP3, ARSB, ATP6V0A4, ATP7A, CLCN5, CLDN16, CLIC6, CLU, CUBN, DAB2, EGF, FAM3D, KCNJ1, KCNJ16, PKD2, PRLR, RAB19, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC18A1, SLC22A4, SLC25A48, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, TCN2, TRPM6, UPK3A, WNK1	1071	transport
GO:0051179	2.226e-03	28.39	48 AP1G1, AP1S3, AQP3, ARSB, ATP6V0A4, ATP7A, CLCN5, CLDN16, CLIC6, CLU, CUBN, DAB2, DPP4, EGF, F2RL1, FAM3D, FERMT1, KCNJ1, KCNJ16, MAP3K1, PKD2, PRLR, RAB19, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC18A1, SLC22A4, SLC25A48, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, TCN2, TRPM6, UPK3A, WNK1	1254	localization
GO:0050909	1.411e-02	0.1358	3 SCNN1A, SCNN1B, SCNN1G	6	sensory perception of taste
GO:0046903	1.986e-02	4.347	13 AQP3, ATP6V0A4, CLCN5, CLDN16, DAB2, EGF, FAM3D, KCNJ1, PRLR, SCNN1A, SCNN1B, SCNN1G, SLC22A4	192	secretion
GO:0015695	2.140e-02	0.1585	3 RHAG, RHCG, SLC22A4	7	organic cation transport
GO:0015889	2.692e-02	0.04528	2 CUBN, TCN2	2	cobalamin transport
GO:0032836	2.692e-02	0.04528	2 COL4A3, COL4A4	2	glomerular basement membrane development
GO:0051180	2.971e-02	0.1811	3 CUBN, SLC22A4, TCN2	8	vitamin transport
GO:0015849	3.915e-02	1.562	7 SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC22A4, SLC6A19, SLC7A9	69	organic acid transport
GO:0046942	3.915e-02	1.562	7 SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC22A4, SLC6A19, SLC7A9	69	carboxylic acid transport
GO:0048704	4.119e-02	0.4528	4 GSC, HOXB7, HOXD10, HOXD4	20	embryonic skeletal system morphogenesis

Id	Pvalue	ExpCount	Count	Size	Term
GO:0045177	1.332e-07	1.724	14 ATP6V0A4, CLCN5, CUBN, DPP4, LGMN, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC22A4, SLC5A12, TRPM6, UPK3A	75	apical part of cell
GO:0016324	6.435e-07	1.356	12 ATP6V0A4, CUBN, DPP4, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC22A4, SLC5A12, TRPM6, UPK3A	59	apical plasma membrane
GO:0044459	1.737e-05	16.58	38 AQP3, ATP6V0A4, ATP7A, CASR, CLCN5, CLDN16, CLDN19, CUBN, DPP4, EREG, F2RL1, FERMT1, ITGB6, KCNJ1, KCNJ16, KL, MEP1A, MEP1B, NOX4, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC22A4, SLC34A1, SLC4A4, SLC5A12, SLC6A19, SLC7A9, ST14, TMPRSS2, TRPM6, UPK3A	721	plasma membrane part
GO:0031224	2.394e-05	37.18	63 A4GNT, AQP3, ATP6V0A4, ATP7A, CASR, CDCP1, CLCN5, CLDN16, CLDN19, CLIC6, DPP4, EGF, EREG, F2RL1, FRAS1, GALNT11, GALNT14, ILDR1, ITGB6, KCNJ1, KCNJ16, KL, LYPD2, MARVELD3, MEP1A, MEP1B, NOX4, PAQR5, PKD2, PRLR, PTPRQ, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC18A1, SLC22A4, SLC25A48, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SPTLC2, ST14, SUSD2, TMEM171, TMEM27, TMIGD1, TMPRSS13, TMPRSS2, TRPM6, UPK3A, ZPLD1	1617	intrinsic to membrane
GO:0005886	2.527e-05	26.05	50 ANKS4B, AQP3, ATP6V0A4, ATP7A, CASR, CDCP1, CLCN5, CLDN16, CLDN19, CLIC6, CUBN, DPP4, EGF, EREG, F2RL1, FERMT1, FRAS1, ILDR1, ITGB6, KCNJ1, KCNJ16, KL, LYPD2, MEP1A, MEP1B, NOX4, PKD2, RAB19, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC34A1, SLC4A4, SLC5A12, SLC5A9, SLC6A19, SLC7A9, ST14, TMPRSS2, TRPM6, UPK3A	1133	plasma membrane
GO:0016021	2.742e-05	36.42	62 A4GNT, AQP3, ATP6V0A4, ATP7A, CASR, CDCP1, CLCN5, CLDN16, CLDN19, CLIC6, DPP4, EGF, EREG, F2RL1, FRAS1, GALNT11, GALNT14, ILDR1, ITGB6, KCNJ1, KCNJ16, KL, MARVELD3, MEP1A, MEP1B, NOX4, PAQR5, PKD2, PRLR, PTPRQ, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC18A1, SLC22A4, SLC25A48, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SPTLC2, ST14, SUSD2, TMEM171, TMEM27, TMIGD1, TMPRSS13, TMPRSS2, TRPM6, UPK3A, ZPLD1	1584	integral to membrane
GO:0044425	1.160e-04	43.66	68 A4GNT, AP1G1, AP1S3, AQP3, ATP6V0A4, ATP7A, CASR, CDCP1, CLCN5, CLDN16, CLDN19, CLIC6, CUBN, DAB2, DPP4, EGF, EREG, F2RL1, FERMT1, FRAS1, GALNT11, GALNT14, ILDR1, ITGB6, KCNJ1, KCNJ16, KL, LYPD2, MARVELD3, MEP1A, MEP1B, NOX4, PAQR5, PKD2, PRLR, PTPRQ, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC18A1, SLC22A4, SLC25A48, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SPTLC2, ST14, SUSD2, TMEM171, TMEM27, TMIGD1, TMPRSS13, TMPRSS2, TRPM6, UPK3A, ZPLD1	1899	membrane part
GO:0034706	4.668e-04	0.06897	3 SCNN1A, SCNN1B, SCNN1G	3	sodium channel complex
GO:0005903	1.300e-03	0.4138	5 ATP6V0A4, CUBN, SLC13A1, SLC34A1, TRPM6	18	brush border
GO:0005887	1.494e-03	9.495	23 CASR, CLCN5, EREG, F2RL1, ITGB6, KCNJ1, KCNJ16, KL, MEP1A, MEP1B, RHAG, RHCG, SCNN1G, SLC10A2, SLC16A2, SLC16A4, SLC22A4, SLC34A1, SLC4A4, SLC6A19, SLC7A9, ST14, TMPRSS2	413	integral to plasma membrane
GO:0031226	2.046e-03	9.725	23 CASR, CLCN5, EREG, F2RL1, ITGB6, KCNJ1, KCNJ16, KL, MEP1A, MEP1B, RHAG, RHCG, SCNN1G, SLC10A2, SLC16A2, SLC16A4, SLC22A4, SLC34A1, SLC4A4, SLC6A19, SLC7A9, ST14, TMPRSS2	423	intrinsic to plasma membrane
GO:0031526	4.140e-03	0.2989	4 ATP6V0A4, CUBN, SLC34A1, TRPM6	13	brush border membrane
GO:0031253	8.646e-03	0.9886	6 ATP6V0A4, CUBN, DPP4, FERMT1, SLC34A1, TRPM6	43	cell projection membrane
GO:0005624	9.753e-03	6.299	16 A4GNT, CUBN, DPP4, HSD11B2, KL, MAP3K1, MEP1A, MEP1B, SCNN1A, SCNN1B, SCNN1G, SLC13A3, SLC16A2, SLC16A4, SLC18A1, WNK1	274	membrane fraction
GO:0016020	1.179e-02	53.5	71 A4GNT, ANKS4B, AP1G1, AP1S3, AQP3, ATP6V0A4, ATP7A, CASR, CDCP1, CLCN5, CLDN16, CLDN19, CLIC6, CUBN, DAB2, DPP4, EGF, EREG, F2RL1, FERMT1, FRAS1, GALNT11, GALNT14, ILDR1, ITGB6, KCNJ1, KCNJ16, KL, LYPD2, MARVELD3, MEP1A, MEP1B, NOX4, PAQR5, PKD2, PRLR, PTPRQ, RAB19, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC18A1, SLC22A4, SLC25A48, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SPTLC2, ST14, SUSD2, TFCP2L1, TMEM171, TMEM27, TMIGD1, TMPRSS13, TMPRSS2, TRPM6, UPK3A, ZPLD1	2327	membrane
GO:0005626	1.341e-02	6.529	16 A4GNT, CUBN, DPP4, HSD11B2, KL, MAP3K1, MEP1A, MEP1B, SCNN1A, SCNN1B, SCNN1G, SLC13A3, SLC16A2, SLC16A4, SLC18A1, WNK1	284	insoluble fraction
GO:0016323	2.008e-02	2.115	8 AQP3, ATP7A, CLDN19, FERMT1, NOX4, RHCG, SLC4A4, ST14	92	basolateral plasma membrane
GO:0000267	3.308e-02	8.668	18 A4GNT, CUBN, DPP4, EGF, GCLM, HSD11B2, KL, MAP3K1, MEP1A, MEP1B, SCNN1A, SCNN1B, SCNN1G, SLC13A3, SLC16A2, SLC16A4, SLC18A1, WNK1	377	cell fraction
GO:0005587	4.322e-02	0.09196	2 COL4A3, COL4A4	4	collagen type IV

Id	Pvalue	ExpCount	Count	Size	Term
GO:0015293	3.335e-07	1.34	13 SLC10A2, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, SLC6A19	56	symporter activity
GO:0005215	4.699e-07	10.87	34 AP1G1, AP1S3, AQP3, ATP6V0A4, ATP7A, CLCN5, CLDN16, CLIC6, CUBN, KCNJ1, KCNJ16, PKD2, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC18A1, SLC22A4, SLC25A48, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, TRPM6	454	transporter activity
GO:0022857	7.469e-07	8.808	30 AQP3, ATP6V0A4, ATP7A, CLCN5, CLDN16, CLIC6, KCNJ1, KCNJ16, PKD2, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC18A1, SLC22A4, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, TRPM6	368	transmembrane transporter activity
GO:0022804	7.469e-07	3.112	18 ATP6V0A4, ATP7A, CLCN5, SLC10A2, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC18A1, SLC22A4, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9	130	active transmembrane transporter activity
GO:0015291	3.789e-06	2.011	14 CLCN5, SLC10A2, SLC13A1, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC34A1, SLC4A4, SLC5A11, SLC5A12, SLC5A9, SLC6A19	84	secondary active transmembrane transporter activity
GO:0022892	6.883e-06	9.287	29 AP1G1, AP1S3, AQP3, ATP6V0A4, ATP7A, CLCN5, CLDN16, CLIC6, KCNJ1, KCNJ16, PKD2, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC16A2, SLC16A4, SLC18A1, SLC22A4, SLC34A1, SLC4A4, SLC5A9, SLC6A19, SLC7A9, TRPM6	388	substrate-specific transporter activity
GO:0022891	7.486e-06	8.186	27 AQP3, ATP6V0A4, ATP7A, CLCN5, CLDN16, CLIC6, KCNJ1, KCNJ16, PKD2, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC16A2, SLC16A4, SLC18A1, SLC22A4, SLC34A1, SLC4A4, SLC5A9, SLC6A19, SLC7A9, TRPM6	342	substrate-specific transmembrane transporter activity
GO:0022890	5.137e-05	1.843	12 ATP6V0A4, ATP7A, CLDN16, RHAG, RHCG, SLC10A2, SLC13A1, SLC13A3, SLC22A4, SLC4A4, SLC5A9, SLC6A19	77	inorganic cation transmembrane transporter activity
GO:0008324	2.219e-04	5.433	19 ATP6V0A4, ATP7A, CLDN16, KCNJ1, KCNJ16, PKD2, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC22A4, SLC4A4, SLC5A9, SLC6A19, TRPM6	227	cation transmembrane transporter activity
GO:0015075	2.655e-04	7.181	22 ATP6V0A4, ATP7A, CLCN5, CLDN16, CLIC6, KCNJ1, KCNJ16, PKD2, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC22A4, SLC34A1, SLC4A4, SLC5A9, SLC6A19, TRPM6	300	ion transmembrane transporter activity
GO:0046873	3.602e-03	1.34	8 ATP7A, CLDN16, SLC10A2, SLC13A1, SLC13A3, SLC4A4, SLC5A9, SLC6A19	56	metal ion transmembrane transporter activity
GO:0015101	4.029e-03	0.09574	3 RHAG, RHCG, SLC22A4	4	organic cation transmembrane transporter activity
GO:0015280	4.029e-03	0.09574	3 SCNN1A, SCNN1B, SCNN1G	4	amiloride-sensitive sodium channel activity
GO:0005272	6.109e-03	0.2633	4 PKD2, SCNN1A, SCNN1B, SCNN1G	11	sodium channel activity
GO:0015081	6.973e-03	0.7899	6 SLC10A2, SLC13A1, SLC13A3, SLC4A4, SLC5A9, SLC6A19	33	sodium ion transmembrane transporter activity
GO:0015294	1.025e-02	0.8617	6 SLC10A2, SLC13A1, SLC13A3, SLC4A4, SLC5A9, SLC6A19	36	solute:cation symporter activity
GO:0050699	1.340e-02	0.1436	3 SCNN1A, SCNN1B, SCNN1G	6	WW domain binding
GO:0005342	1.459e-02	0.9335	6 SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC6A19, SLC7A9	39	organic acid transmembrane transporter activity
GO:0046943	1.459e-02	0.9335	6 SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC6A19, SLC7A9	39	carboxylic acid transmembrane transporter activity
GO:0015077	1.757e-02	1.364	7 ATP6V0A4, SLC10A2, SLC13A1, SLC13A3, SLC4A4, SLC5A9, SLC6A19	57	monovalent inorganic cation transmembrane transporter activity
GO:0005044	2.058e-02	0.383	4 SUSD2, TINAG, TMPRSS13, TMPRSS2	16	scavenger receptor activity
GO:0008519	2.443e-02	0.04787	2 RHAG, RHCG	2	ammonium transmembrane transporter activity
GO:0008509	3.244e-02	1.556	7 CLCN5, CLIC6, PKD2, SLC13A1, SLC13A3, SLC34A1, SLC4A4	65	anion transmembrane transporter activity
GO:0005275	3.700e-02	0.7899	5 SLC13A3, SLC18A1, SLC22A4, SLC6A19, SLC7A9	33	amine transmembrane transporter activity
GO:0008028	3.722e-02	0.2154	3 SLC10A2, SLC16A2, SLC16A4	9	monocarboxylic acid transmembrane transporter activity
GO:0005247	4.711e-02	0.2394	3 CLCN5, CLIC6, PKD2	10	voltage-gated chloride channel activity

Id	Pvalue	ExpCount	Count	Size	Term
04960	9.088e-04	0.3185	5 HSD11B2, KCNJ1, SCNN1A, SCNN1B, SCNN1G	16	Aldosterone-regulated sodium reabsorption
04742	3.138e-02	0.199	3 SCNN1A, SCNN1B, SCNN1G	10	Taste transduction

No enriched terms

No enriched terms

Entrez genes

A4GNTalpha-1,4-N-acetylglucosaminyltransferase (ENSG00000118017), score: 0.79 AGPHD1aminoglycoside phosphotransferase domain containing 1 (ENSG00000188266), score: 0.73 ANKS4Bankyrin repeat and sterile alpha motif domain containing 4B (ENSG00000175311), score: 0.76 AP1G1adaptor-related protein complex 1, gamma 1 subunit (ENSG00000166747), score: 0.7 AP1S3adaptor-related protein complex 1, sigma 3 subunit (ENSG00000152056), score: 0.8 AQP3aquaporin 3 (Gill blood group) (ENSG00000165272), score: 0.69 ARHGEF38Rho guanine nucleotide exchange factor (GEF) 38 (ENSG00000138784), score: 0.75 ARSBarylsulfatase B (ENSG00000113273), score: 0.75 ASPAaspartoacylase (ENSG00000108381), score: 0.75 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.91 ATP7AATPase, Cu++ transporting, alpha polypeptide (ENSG00000165240), score: 0.69 BPNT13'(2'), 5'-bisphosphate nucleotidase 1 (ENSG00000162813), score: 0.8 C11orf54chromosome 11 open reading frame 54 (ENSG00000182919), score: 0.72 C1orf116chromosome 1 open reading frame 116 (ENSG00000182795), score: 0.7 CALML4calmodulin-like 4 (ENSG00000129007), score: 0.79 CASRcalcium-sensing receptor (ENSG00000036828), score: 0.92 CDCP1CUB domain containing protein 1 (ENSG00000163814), score: 0.69 CLCN5chloride channel 5 (ENSG00000171365), score: 0.68 CLDN16claudin 16 (ENSG00000113946), score: 0.9 CLDN19claudin 19 (ENSG00000164007), score: 0.96 CLIC6chloride intracellular channel 6 (ENSG00000159212), score: 0.88 CLUclusterin (ENSG00000120885), score: -0.7 COL4A3collagen, type IV, alpha 3 (Goodpasture antigen) (ENSG00000169031), score: 0.84 COL4A4collagen, type IV, alpha 4 (ENSG00000081052), score: 0.99 CUBNcubilin (intrinsic factor-cobalamin receptor) (ENSG00000107611), score: 0.97 DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (ENSG00000153071), score: 0.8 DAOD-amino-acid oxidase (ENSG00000110887), score: 0.71 DHDPSLdihydrodipicolinate synthase-like, mitochondrial (ENSG00000241935), score: 0.68 DPP4dipeptidyl-peptidase 4 (ENSG00000197635), score: 0.67 EGFepidermal growth factor (ENSG00000138798), score: 0.76 EHFets homologous factor (ENSG00000135373), score: 0.88 EREGepiregulin (ENSG00000124882), score: 0.68 ESRP1epithelial splicing regulatory protein 1 (ENSG00000104413), score: 0.78 F2RL1coagulation factor II (thrombin) receptor-like 1 (ENSG00000164251), score: 0.72 FAM3Dfamily with sequence similarity 3, member D (ENSG00000198643), score: 0.68 FERMT1fermitin family member 1 (ENSG00000101311), score: 0.89 FOXI1forkhead box I1 (ENSG00000168269), score: 0.8 FRAS1Fraser syndrome 1 (ENSG00000138759), score: 0.7 GALNT11UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) (ENSG00000178234), score: 0.68 GALNT14UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) (ENSG00000158089), score: 0.71 GATA3GATA binding protein 3 (ENSG00000107485), score: 0.75 GCLMglutamate-cysteine ligase, modifier subunit (ENSG00000023909), score: 0.7 GRHL2grainyhead-like 2 (Drosophila) (ENSG00000083307), score: 0.77 GSCgoosecoid homeobox (ENSG00000133937), score: 0.84 HNF4Ghepatocyte nuclear factor 4, gamma (ENSG00000164749), score: 0.68 HOXA10homeobox A10 (ENSG00000153807), score: 0.86 HOXB7homeobox B7 (ENSG00000120087), score: 0.9 HOXD10homeobox D10 (ENSG00000128710), score: 0.94 HOXD4homeobox D4 (ENSG00000170166), score: 0.8 HSD11B2hydroxysteroid (11-beta) dehydrogenase 2 (ENSG00000176387), score: 0.75 ILDR1immunoglobulin-like domain containing receptor 1 (ENSG00000145103), score: 0.79 ITGB6integrin, beta 6 (ENSG00000115221), score: 0.75 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.84 KCNJ16potassium inwardly-rectifying channel, subfamily J, member 16 (ENSG00000153822), score: 0.88 KLklotho (ENSG00000133116), score: 0.85 KLHL14kelch-like 14 (Drosophila) (ENSG00000197705), score: 0.76 KRT80keratin 80 (ENSG00000167767), score: 0.88 LAD1ladinin 1 (ENSG00000159166), score: 0.71 LGMNlegumain (ENSG00000100600), score: 0.82 LRRC58leucine rich repeat containing 58 (ENSG00000163428), score: 0.77 LYPD2LY6/PLAUR domain containing 2 (ENSG00000197353), score: 0.87 MAP3K1mitogen-activated protein kinase kinase kinase 1 (ENSG00000095015), score: 0.72 MARVELD3MARVEL domain containing 3 (ENSG00000140832), score: 0.69 MEP1Ameprin A, alpha (PABA peptide hydrolase) (ENSG00000112818), score: 0.8 MEP1Bmeprin A, beta (ENSG00000141434), score: 0.79 NOX4NADPH oxidase 4 (ENSG00000086991), score: 0.82 NUAK2NUAK family, SNF1-like kinase, 2 (ENSG00000163545), score: 0.78 PAFAH2platelet-activating factor acetylhydrolase 2, 40kDa (ENSG00000158006), score: 0.67 PAQR5progestin and adipoQ receptor family member V (ENSG00000137819), score: 0.7 PKD2polycystic kidney disease 2 (autosomal dominant) (ENSG00000118762), score: 0.71 PLEKHF2pleckstrin homology domain containing, family F (with FYVE domain) member 2 (ENSG00000175895), score: 0.74 PLS1plastin 1 (ENSG00000120756), score: 0.79 PRLRprolactin receptor (ENSG00000113494), score: 0.77 PTERphosphotriesterase related (ENSG00000165983), score: 0.78 PTPRQprotein tyrosine phosphatase, receptor type, Q (ENSG00000139304), score: 0.71 PYROXD2pyridine nucleotide-disulphide oxidoreductase domain 2 (ENSG00000119943), score: 0.9 RAB19RAB19, member RAS oncogene family (ENSG00000146955), score: 0.83 RASSF6Ras association (RalGDS/AF-6) domain family member 6 (ENSG00000169435), score: 0.87 RHAGRh-associated glycoprotein (ENSG00000112077), score: 0.81 RHCGRh family, C glycoprotein (ENSG00000140519), score: 0.81 SCNN1Asodium channel, nonvoltage-gated 1 alpha (ENSG00000111319), score: 0.7 SCNN1Bsodium channel, nonvoltage-gated 1, beta (ENSG00000168447), score: 0.87 SCNN1Gsodium channel, nonvoltage-gated 1, gamma (ENSG00000166828), score: 0.76 SIM1single-minded homolog 1 (Drosophila) (ENSG00000112246), score: 1 SLC10A2solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (ENSG00000125255), score: 1 SLC13A1solute carrier family 13 (sodium/sulfate symporters), member 1 (ENSG00000081800), score: 0.8 SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (ENSG00000158296), score: 0.7 SLC16A12solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (ENSG00000152779), score: 0.78 SLC16A2solute carrier family 16, member 2 (monocarboxylic acid transporter 8) (ENSG00000147100), score: 0.71 SLC16A4solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (ENSG00000168679), score: 0.86 SLC18A1solute carrier family 18 (vesicular monoamine), member 1 (ENSG00000036565), score: 0.72 SLC22A4solute carrier family 22 (organic cation/ergothioneine transporter), member 4 (ENSG00000197208), score: 0.77 SLC25A48solute carrier family 25, member 48 (ENSG00000145832), score: 0.8 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 1 SLC4A4solute carrier family 4, sodium bicarbonate cotransporter, member 4 (ENSG00000080493), score: 0.66 SLC5A11solute carrier family 5 (sodium/glucose cotransporter), member 11 (ENSG00000158865), score: 0.73 SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12 (ENSG00000148942), score: 0.89 SLC5A9solute carrier family 5 (sodium/glucose cotransporter), member 9 (ENSG00000117834), score: 0.79 SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19 (ENSG00000174358), score: 0.96 SLC7A9solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 (ENSG00000021488), score: 0.69 SPTLC2serine palmitoyltransferase, long chain base subunit 2 (ENSG00000100596), score: 0.71 SRMSsrc-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (ENSG00000125508), score: 0.71 ST14suppression of tumorigenicity 14 (colon carcinoma) (ENSG00000149418), score: 0.69 SUSD2sushi domain containing 2 (ENSG00000099994), score: 0.89 SYDE2synapse defective 1, Rho GTPase, homolog 2 (C. elegans) (ENSG00000097096), score: 0.72 TCN2transcobalamin II (ENSG00000185339), score: 0.66 TFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta) (ENSG00000008196), score: 0.82 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.81 THNSL2threonine synthase-like 2 (S. cerevisiae) (ENSG00000144115), score: 0.67 TINAGtubulointerstitial nephritis antigen (ENSG00000137251), score: 0.78 TMEM171transmembrane protein 171 (ENSG00000157111), score: 0.78 TMEM27transmembrane protein 27 (ENSG00000147003), score: 0.96 TMIGD1transmembrane and immunoglobulin domain containing 1 (ENSG00000182271), score: 0.94 TMPRSS13transmembrane protease, serine 13 (ENSG00000137747), score: 0.77 TMPRSS2transmembrane protease, serine 2 (ENSG00000184012), score: 0.69 TNFAIP8tumor necrosis factor, alpha-induced protein 8 (ENSG00000145779), score: 0.78 TRPM6transient receptor potential cation channel, subfamily M, member 6 (ENSG00000119121), score: 0.9 UPK3Auroplakin 3A (ENSG00000100373), score: 0.86 WNK1WNK lysine deficient protein kinase 1 (ENSG00000060237), score: 0.74 XPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (ENSG00000108039), score: 0.74 ZPLD1zona pellucida-like domain containing 1 (ENSG00000170044), score: 0.9

Non-Entrez genes

Unknown, score:

Id	species	tissue	sex	individual
oan_kd_m_ca1	oan	kd	m	_
gga_kd_f_ca1	gga	kd	f	_
gga_kd_m_ca1	gga	kd	m	_
oan_kd_f_ca1	oan	kd	f	_
mmu_kd_m2_ca1	mmu	kd	m	2
mmu_kd_m1_ca1	mmu	kd	m	1
mmu_kd_f_ca1	mmu	kd	f	_
mdo_kd_m_ca1	mdo	kd	m	_
mdo_kd_f_ca1	mdo	kd	f	_