Previous module | Next module Module #338, TG: 2.2, TC: 3, 146 probes, 146 Entrez genes, 4 conditions

Help | Hide | Top Help | Show | Top Expression data

transition metal ion transport

The directed movement of transition metal ions into, out of, within or between cells by means of some external agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

immune effector process

Any process of the immune system that occurs as part of an immune response.

activation of immune response

Any process that initiates an immune response.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

leukocyte mediated immunity

Any process involved in the carrying out of an immune response by a leukocyte.

lymphocyte mediated immunity

Any process involved in the carrying out of an immune response by a lymphocyte.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

protein maturation by peptide bond cleavage

The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

zinc ion transport

The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

humoral immune response

An immune response mediated through a body fluid.

hemostasis

The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

gene expression

The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

protein processing

Any protein maturation process achieved by the cleavage of peptide bonds.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

coagulation

The process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

all

NA

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

immune effector process

Any process of the immune system that occurs as part of an immune response.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

activation of immune response

Any process that initiates an immune response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

all

NA

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

enzyme inhibitor activity

Stops, prevents or reduces the activity of an enzyme.

endopeptidase inhibitor activity

Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

endopeptidase regulator activity

Modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

enzyme regulator activity

Modulates the activity of an enzyme.

peptidase regulator activity

Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

all

NA

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

endopeptidase inhibitor activity

Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0006957	4.588e-04	0.1415	4 C5, C8A, C8B, VSIG4	5	complement activation, alternative pathway
GO:0050776	4.789e-04	1.981	11 AMBP, C5, C8A, C8B, CD28, EREG, HPX, IL12B, IL15, TLR3, VSIG4	70	regulation of immune response
GO:0042060	7.165e-04	2.49	12 CPB2, EREG, F10, F2, F9, FGB, FGG, IL22RA2, SERPINA10, SERPINC1, TM4SF4, VTN	88	wound healing
GO:0009611	7.409e-04	5.971	19 C5, C8A, C8B, CPB2, EREG, F10, F2, F9, FGB, FGG, IL15, IL22RA2, SERPINA10, SERPINC1, TLR3, TM4SF4, TPST1, VSIG4, VTN	211	response to wounding
GO:0007596	9.149e-04	1.387	9 CPB2, F10, F2, F9, FGB, FGG, IL22RA2, SERPINC1, VTN	49	blood coagulation
GO:0007599	1.055e-03	1.415	9 CPB2, F10, F2, F9, FGB, FGG, IL22RA2, SERPINC1, VTN	50	hemostasis
GO:0050778	1.214e-03	1.443	9 C5, C8A, C8B, EREG, HPX, IL12B, IL15, TLR3, VSIG4	51	positive regulation of immune response
GO:0050817	1.214e-03	1.443	9 CPB2, F10, F2, F9, FGB, FGG, IL22RA2, SERPINC1, VTN	51	coagulation
GO:0006959	1.524e-03	0.566	6 C5, C8A, C8B, CD28, HPX, VSIG4	20	humoral immune response
GO:0002252	2.043e-03	1.556	9 C5, C8A, C8B, CD28, HPX, IL12B, IL15, TLR3, VSIG4	55	immune effector process
GO:0006956	3.718e-03	0.2264	4 C5, C8A, C8B, VSIG4	8	complement activation
GO:0006950	5.099e-03	17.43	34 ALB, AMBP, C5, C8A, C8B, CAPN2, CD28, CPB2, EDEM3, EREG, F10, F2, F9, FAF2, FGB, FGG, HPX, IL12B, IL15, IL22RA2, IRF8, LEAP2, MUTYH, SERPINA10, SERPINC1, SESN1, TAT, TLR3, TM4SF4, TPST1, TRPA1, VSIG4, VTN, XRCC6BP1	616	response to stress
GO:0002455	5.834e-03	0.2547	4 C5, C8A, C8B, HPX	9	humoral immune response mediated by circulating immunoglobulin
GO:0002541	5.834e-03	0.2547	4 C5, C8A, C8B, VSIG4	9	activation of plasma proteins involved in acute inflammatory response
GO:0002684	7.032e-03	2.321	10 C5, C8A, C8B, CD28, EREG, HPX, IL12B, IL15, TLR3, VSIG4	82	positive regulation of immune system process
GO:0045087	7.817e-03	1.5	8 C5, C8A, C8B, EREG, HPX, IL12B, TLR3, VSIG4	53	innate immune response
GO:0006952	7.925e-03	4.952	15 C5, C8A, C8B, CD28, EREG, F2, HPX, IL12B, IL15, IRF8, LEAP2, SERPINC1, TLR3, TPST1, VSIG4	175	defense response
GO:0006829	8.555e-03	0.283	4 SLC30A1, SLC30A10, SLC30A7, SLC39A9	10	zinc ion transport
GO:0008206	1.194e-02	0.3113	4 AKR1D1, CYP39A1, CYP7B1, NR5A2	11	bile acid metabolic process
GO:0048583	1.348e-02	5.264	15 AMBP, C5, C8A, C8B, CD28, CPB2, EREG, F2, HPX, IL12B, IL15, SERPINC1, TLR3, VSIG4, VTN	186	regulation of response to stimulus
GO:0050878	1.723e-02	2.179	9 CPB2, F10, F2, F9, FGB, FGG, IL22RA2, SERPINC1, VTN	77	regulation of body fluid levels
GO:0002682	1.847e-02	3.736	12 ACVR2A, AMBP, C5, C8A, C8B, CD28, EREG, HPX, IL12B, IL15, TLR3, VSIG4	132	regulation of immune system process
GO:0016054	2.032e-02	1.358	7 ACSL5, AKR1D1, AMDHD1, CYP39A1, HAL, TAT, TDO2	48	organic acid catabolic process
GO:0046395	2.032e-02	1.358	7 ACSL5, AKR1D1, AMDHD1, CYP39A1, HAL, TAT, TDO2	48	carboxylic acid catabolic process
GO:0080134	2.061e-02	3.254	11 AMBP, CD28, CPB2, EREG, F2, HPX, IL12B, IL15, SERPINC1, TLR3, VTN	115	regulation of response to stress
GO:0050896	2.220e-02	29.97	47 ACSL5, ALB, AMBP, BLMH, C5, C8A, C8B, CAPN2, CD28, CHRNA5, CPB2, CYP7B1, EDEM3, EREG, ESR1, F10, F2, F9, FAF2, FGB, FGG, HPGDS, HPX, IHH, IL12B, IL15, IL22RA2, IRF8, LEAP2, LHX8, MUTYH, NTSR1, PCK2, PDE6D, SERPINA10, SERPINC1, SESN1, TAT, TLR3, TM4SF4, TPST1, TRPA1, TTPA, UNC119, VSIG4, VTN, XRCC6BP1	1059	response to stimulus
GO:0006699	2.334e-02	0.1698	3 AKR1D1, CYP39A1, CYP7B1	6	bile acid biosynthetic process
GO:0006958	2.334e-02	0.1698	3 C5, C8A, C8B	6	complement activation, classical pathway
GO:0019835	2.334e-02	0.1698	3 C5, C8A, C8B	6	cytolysis
GO:0048584	2.514e-02	2.83	10 C5, C8A, C8B, EREG, HPX, IL12B, IL15, TLR3, VSIG4, VTN	100	positive regulation of response to stimulus
GO:0016485	2.724e-02	1.047	6 C5, C8A, C8B, CAPN2, IHH, VSIG4	37	protein processing
GO:0051604	2.724e-02	1.047	6 C5, C8A, C8B, CAPN2, IHH, VSIG4	37	protein maturation
GO:0035468	2.749e-02	3.962	12 ACVR2A, AKAP12, CXXC5, EREG, ESR1, F10, F2, HPX, TLR3, TWSG1, VTN, WLS	140	positive regulation of signaling pathway
GO:0031347	3.194e-02	1.5	7 CD28, EREG, HPX, IL12B, IL15, SERPINC1, TLR3	53	regulation of defense response
GO:0042108	3.243e-02	0.4245	4 CD28, EREG, IL12B, TLR3	15	positive regulation of cytokine biosynthetic process
GO:0043900	3.243e-02	0.4245	4 CD28, IL12B, IL15, IRF8	15	regulation of multi-organism process
GO:0044403	3.243e-02	0.4245	4 ALB, IL12B, IRF8, TLR3	15	symbiosis, encompassing mutualism through parasitism
GO:0006882	3.746e-02	0.0566	2 SLC30A1, SLC30A7	2	cellular zinc ion homeostasis
GO:0030573	3.746e-02	0.0566	2 AKR1D1, CYP39A1	2	bile acid catabolic process
GO:0044003	3.746e-02	0.0566	2 ALB, TLR3	2	modification by symbiont of host morphology or physiology
GO:0055069	3.746e-02	0.0566	2 SLC30A1, SLC30A7	2	zinc ion homeostasis
GO:0000041	3.835e-02	0.7641	5 SLC30A1, SLC30A10, SLC30A7, SLC31A1, SLC39A9	27	transition metal ion transport
GO:0045088	3.949e-02	0.4528	4 EREG, HPX, IL12B, TLR3	16	regulation of innate immune response
GO:0010647	4.334e-02	4.245	12 ACVR2A, AKAP12, CXXC5, EREG, ESR1, F10, F2, HPX, TLR3, TWSG1, VTN, WLS	150	positive regulation of cell communication
GO:0006955	4.822e-02	4.924	13 AMBP, C5, C8A, C8B, CD28, EREG, HPX, IL12B, IL15, IRF8, TLR3, VSIG4, VTN	174	immune response

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005576	2.237e-05	15.07	36 ALB, AMBP, C5, C8A, C8B, CA6, CPB2, DHRS11, EREG, F10, F2, F9, FAM20A, FAM3C, FETUB, FGB, FGG, GAS6, GPLD1, HHIPL1, HPX, IHH, IL12B, IL15, IL22RA2, LEAP2, MMP13, PLA2G12B, PRDX4, PTPRG, SERPINA10, SERPINC1, SPINK4, SPP2, TWSG1, VTN	533	extracellular region
GO:0005615	5.915e-05	6.391	21 ALB, C5, C8A, C8B, CPB2, EREG, F2, FGB, FGG, GAS6, HPX, IHH, IL12B, IL15, IL22RA2, MMP13, PRDX4, PTPRG, SERPINC1, TWSG1, VTN	226	extracellular space
GO:0044421	2.219e-03	9.05	22 ALB, C5, C8A, C8B, CPB2, EREG, F2, FGB, FGG, GAS6, GPLD1, HPX, IHH, IL12B, IL15, IL22RA2, MMP13, PRDX4, PTPRG, SERPINC1, TWSG1, VTN	320	extracellular region part
GO:0005579	2.493e-03	0.1131	3 C5, C8A, C8B	4	membrane attack complex
GO:0046581	3.535e-02	0.08484	2 ABCB11, ABCC2	3	intercellular canaliculus

Id	Pvalue	ExpCount	Count	Size	Term
GO:0004866	2.770e-03	0.9506	7 AMBP, C5, FETUB, SERPINA10, SERPINC1, SPINK4, SPP2	34	endopeptidase inhibitor activity
GO:0061135	3.221e-03	0.9786	7 AMBP, C5, FETUB, SERPINA10, SERPINC1, SPINK4, SPP2	35	endopeptidase regulator activity
GO:0030414	3.765e-03	1.007	7 AMBP, C5, FETUB, SERPINA10, SERPINC1, SPINK4, SPP2	36	peptidase inhibitor activity
GO:0061134	9.411e-03	1.202	7 AMBP, C5, FETUB, SERPINA10, SERPINC1, SPINK4, SPP2	43	peptidase regulator activity
GO:0004307	3.093e-02	0.05592	2 CEPT1, EPT1	2	ethanolaminephosphotransferase activity
GO:0008396	3.093e-02	0.05592	2 CYP39A1, CYP7B1	2	oxysterol 7-alpha-hydroxylase activity
GO:0019855	3.093e-02	0.05592	2 AMBP, SLC30A1	2	calcium channel inhibitor activity

Id	Pvalue	ExpCount	Count	Size	Term
04610	4.285e-07	0.8233	10 C5, C8A, C8B, CPB2, F10, F2, F9, FGB, FGG, SERPINC1	21	Complement and coagulation cascades
00120	4.250e-03	0.1176	3 AKR1D1, CYP39A1, CYP7B1	3	Primary bile acid biosynthesis
00565	1.890e-02	0.392	4 CEPT1, EPT1, PAFAH2, PLA2G12B	10	Ether lipid metabolism

No enriched terms

No enriched terms

Entrez genes

ABCA12ATP-binding cassette, sub-family A (ABC1), member 12 (ENSG00000144452), score: 0.66 ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ENSG00000073734), score: 0.48 ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ENSG00000023839), score: 0.45 ABHD5abhydrolase domain containing 5 (ENSG00000011198), score: 0.48 ACSL5acyl-CoA synthetase long-chain family member 5 (ENSG00000197142), score: 0.46 ACVR2Aactivin A receptor, type IIA (ENSG00000121989), score: 0.56 ADSLadenylosuccinate lyase (ENSG00000239900), score: 0.63 AKAP12A kinase (PRKA) anchor protein 12 (ENSG00000131016), score: -0.54 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.47 ALBalbumin (ENSG00000163631), score: 0.5 ALDH9A1aldehyde dehydrogenase 9 family, member A1 (ENSG00000143149), score: 0.61 AMBPalpha-1-microglobulin/bikunin precursor (ENSG00000106927), score: 0.47 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.54 AP1S3adaptor-related protein complex 1, sigma 3 subunit (ENSG00000152056), score: 0.51 AP3M1adaptor-related protein complex 3, mu 1 subunit (ENSG00000185009), score: 0.54 APBB2amyloid beta (A4) precursor protein-binding, family B, member 2 (ENSG00000163697), score: -0.51 ARL3ADP-ribosylation factor-like 3 (ENSG00000138175), score: -0.5 ARL5BADP-ribosylation factor-like 5B (ENSG00000165997), score: 0.47 BLMHbleomycin hydrolase (ENSG00000108578), score: 0.45 C5complement component 5 (ENSG00000106804), score: 0.47 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.46 C8Bcomplement component 8, beta polypeptide (ENSG00000021852), score: 0.5 CA6carbonic anhydrase VI (ENSG00000131686), score: 1 CAPN2calpain 2, (m/II) large subunit (ENSG00000162909), score: -0.57 CD28CD28 molecule (ENSG00000178562), score: 0.51 CEPT1choline/ethanolamine phosphotransferase 1 (ENSG00000134255), score: 0.6 CHRNA5cholinergic receptor, nicotinic, alpha 5 (ENSG00000169684), score: 0.49 CLDN1claudin 1 (ENSG00000163347), score: 0.52 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.47 CUEDC2CUE domain containing 2 (ENSG00000107874), score: -0.59 CXXC5CXXC finger 5 (ENSG00000171604), score: -0.6 CYB5R2cytochrome b5 reductase 2 (ENSG00000166394), score: 0.46 CYP39A1cytochrome P450, family 39, subfamily A, polypeptide 1 (ENSG00000146233), score: 0.63 CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1 (ENSG00000172817), score: 0.54 DBR1debranching enzyme homolog 1 (S. cerevisiae) (ENSG00000138231), score: 0.55 DENND5ADENN/MADD domain containing 5A (ENSG00000184014), score: -0.61 DHRS11dehydrogenase/reductase (SDR family) member 11 (ENSG00000108272), score: -0.53 DHTKD1dehydrogenase E1 and transketolase domain containing 1 (ENSG00000181192), score: 0.46 EDEM3ER degradation enhancer, mannosidase alpha-like 3 (ENSG00000116406), score: 0.53 EPT1ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific) (ENSG00000138018), score: 0.5 EREGepiregulin (ENSG00000124882), score: 0.46 ERGIC2ERGIC and golgi 2 (ENSG00000087502), score: 0.45 ERLEC1endoplasmic reticulum lectin 1 (ENSG00000068912), score: 0.55 ESR1estrogen receptor 1 (ENSG00000091831), score: 0.51 F10coagulation factor X (ENSG00000126218), score: 0.55 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.46 F9coagulation factor IX (ENSG00000101981), score: 0.55 FAF2Fas associated factor family member 2 (ENSG00000113194), score: 0.53 FAM20Afamily with sequence similarity 20, member A (ENSG00000108950), score: 0.51 FAM3Cfamily with sequence similarity 3, member C (ENSG00000196937), score: -0.53 FBXL20F-box and leucine-rich repeat protein 20 (ENSG00000108306), score: 0.49 FETUBfetuin B (ENSG00000090512), score: 0.58 FGBfibrinogen beta chain (ENSG00000171564), score: 0.45 FGGfibrinogen gamma chain (ENSG00000171557), score: 0.47 FZD5frizzled homolog 5 (Drosophila) (ENSG00000163251), score: 0.57 GAS6growth arrest-specific 6 (ENSG00000183087), score: -0.55 GOLIM4golgi integral membrane protein 4 (ENSG00000173905), score: 0.5 GPLD1glycosylphosphatidylinositol specific phospholipase D1 (ENSG00000112293), score: 0.46 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.58 HHIPL1HHIP-like 1 (ENSG00000182218), score: 0.45 HNF4Ghepatocyte nuclear factor 4, gamma (ENSG00000164749), score: 0.45 HPGDShematopoietic prostaglandin D synthase (ENSG00000163106), score: 0.53 HPXhemopexin (ENSG00000110169), score: 0.5 IHHIndian hedgehog (ENSG00000163501), score: 0.46 IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (ENSG00000113302), score: 0.66 IL15interleukin 15 (ENSG00000164136), score: 0.52 IL22RA2interleukin 22 receptor, alpha 2 (ENSG00000164485), score: 0.87 IRF8interferon regulatory factor 8 (ENSG00000140968), score: 0.45 IYDiodotyrosine deiodinase (ENSG00000009765), score: 0.56 KLHDC8Bkelch domain containing 8B (ENSG00000185909), score: -0.5 KLHL25kelch-like 25 (Drosophila) (ENSG00000183655), score: 0.48 LACTBlactamase, beta (ENSG00000103642), score: 0.46 LAPTM4Blysosomal protein transmembrane 4 beta (ENSG00000104341), score: -0.59 LEAP2liver expressed antimicrobial peptide 2 (ENSG00000164406), score: 0.5 LHX8LIM homeobox 8 (ENSG00000162624), score: 0.67 LOC100292021similar to thioredoxin peroxidase (ENSG00000123131), score: 0.52 LRP11low density lipoprotein receptor-related protein 11 (ENSG00000120256), score: -0.5 LRRC15leucine rich repeat containing 15 (ENSG00000172061), score: 0.72 LRRC31leucine rich repeat containing 31 (ENSG00000114248), score: 0.65 MAT1Amethionine adenosyltransferase I, alpha (ENSG00000151224), score: 0.49 MKLN1muskelin 1, intracellular mediator containing kelch motifs (ENSG00000128585), score: 0.62 MMP13matrix metallopeptidase 13 (collagenase 3) (ENSG00000137745), score: 0.51 MTA1metastasis associated 1 (ENSG00000182979), score: -0.63 MTTPmicrosomal triglyceride transfer protein (ENSG00000138823), score: 0.49 MUTYHmutY homolog (E. coli) (ENSG00000132781), score: 0.53 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.48 NRBP1nuclear receptor binding protein 1 (ENSG00000115216), score: -0.55 NTSR1neurotensin receptor 1 (high affinity) (ENSG00000101188), score: 0.46 OIT3oncoprotein induced transcript 3 (ENSG00000138315), score: 0.48 ONECUT1one cut homeobox 1 (ENSG00000169856), score: 0.48 PAFAH2platelet-activating factor acetylhydrolase 2, 40kDa (ENSG00000158006), score: 0.47 PANK1pantothenate kinase 1 (ENSG00000152782), score: 0.47 PARP6poly (ADP-ribose) polymerase family, member 6 (ENSG00000137817), score: -0.5 PCK2phosphoenolpyruvate carboxykinase 2 (mitochondrial) (ENSG00000100889), score: 0.46 PDE6Dphosphodiesterase 6D, cGMP-specific, rod, delta (ENSG00000156973), score: -0.51 PHF16PHD finger protein 16 (ENSG00000102221), score: 0.46 PLA2G12Bphospholipase A2, group XIIB (ENSG00000138308), score: 0.45 PPP2R5Dprotein phosphatase 2, regulatory subunit B', delta (ENSG00000112640), score: -0.56 PTPRGprotein tyrosine phosphatase, receptor type, G (ENSG00000144724), score: 0.51 RPIAribose 5-phosphate isomerase A (ENSG00000153574), score: 0.45 SAR1BSAR1 homolog B (S. cerevisiae) (ENSG00000152700), score: 0.52 SASH3SAM and SH3 domain containing 3 (ENSG00000122122), score: 0.48 SDR42E1short chain dehydrogenase/reductase family 42E, member 1 (ENSG00000184860), score: 0.53 SEBOXSEBOX homeobox (ENSG00000109072), score: 0.46 SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (ENSG00000140093), score: 0.48 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.47 SESN1sestrin 1 (ENSG00000080546), score: 0.46 SGCEsarcoglycan, epsilon (ENSG00000127990), score: -0.66 SH3GLB2SH3-domain GRB2-like endophilin B2 (ENSG00000148341), score: -0.56 SLC26A5solute carrier family 26, member 5 (prestin) (ENSG00000170615), score: 0.6 SLC2A9solute carrier family 2 (facilitated glucose transporter), member 9 (ENSG00000109667), score: 0.5 SLC30A1solute carrier family 30 (zinc transporter), member 1 (ENSG00000170385), score: 0.57 SLC30A10solute carrier family 30, member 10 (ENSG00000196660), score: 0.5 SLC30A7solute carrier family 30 (zinc transporter), member 7 (ENSG00000162695), score: 0.54 SLC31A1solute carrier family 31 (copper transporters), member 1 (ENSG00000136868), score: 0.48 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.52 SLC39A9solute carrier family 39 (zinc transporter), member 9 (ENSG00000029364), score: 0.52 SPINK4serine peptidase inhibitor, Kazal type 4 (ENSG00000122711), score: 0.72 SPP2secreted phosphoprotein 2, 24kDa (ENSG00000072080), score: 0.61 SRSF4serine/arginine-rich splicing factor 4 (ENSG00000116350), score: -0.6 SSR1signal sequence receptor, alpha (ENSG00000124783), score: 0.56 STK24serine/threonine kinase 24 (ENSG00000102572), score: -0.51 STOML3stomatin (EPB72)-like 3 (ENSG00000133115), score: 0.69 TAAR1trace amine associated receptor 1 (ENSG00000146399), score: 0.67 TATtyrosine aminotransferase (ENSG00000198650), score: 0.48 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.46 THUMPD2THUMP domain containing 2 (ENSG00000138050), score: 0.46 TLR3toll-like receptor 3 (ENSG00000164342), score: 0.67 TM4SF4transmembrane 4 L six family member 4 (ENSG00000169903), score: 0.55 TM7SF4transmembrane 7 superfamily member 4 (ENSG00000164935), score: 0.56 TMEM135transmembrane protein 135 (ENSG00000166575), score: 0.5 TMEM195transmembrane protein 195 (ENSG00000187546), score: 0.62 TMEM41Btransmembrane protein 41B (ENSG00000166471), score: 0.52 TPST1tyrosylprotein sulfotransferase 1 (ENSG00000169902), score: 0.47 TRPA1transient receptor potential cation channel, subfamily A, member 1 (ENSG00000104321), score: 0.52 TSPAN15tetraspanin 15 (ENSG00000099282), score: -0.52 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.61 TWSG1twisted gastrulation homolog 1 (Drosophila) (ENSG00000128791), score: -0.59 UNC119unc-119 homolog (C. elegans) (ENSG00000109103), score: -0.57 USO1USO1 vesicle docking protein homolog (yeast) (ENSG00000138768), score: 0.6 VSIG4V-set and immunoglobulin domain containing 4 (ENSG00000155659), score: 0.5 WDFY2WD repeat and FYVE domain containing 2 (ENSG00000139668), score: 0.54 WLSwntless homolog (Drosophila) (ENSG00000116729), score: -0.5 XRCC6BP1XRCC6 binding protein 1 (ENSG00000166896), score: 0.45 YIPF5Yip1 domain family, member 5 (ENSG00000145817), score: 0.59 ZC3H12Dzinc finger CCCH-type containing 12D (ENSG00000178199), score: 0.6

Non-Entrez genes

Unknown, score:

Id	species	tissue	sex	individual
oan_lv_f_ca1	oan	lv	f	_
oan_lv_m_ca1	oan	lv	m	_
gga_lv_f_ca1	gga	lv	f	_
gga_lv_m_ca1	gga	lv	m	_