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system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

organic acid transport

The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells by means of some external agent such as a transporter or pore.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

carboxylic acid transport

The directed movement of carboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

all

NA

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

cation channel complex

An ion channel complex through which cations pass.

sodium channel complex

An ion channel complex through which sodium ions pass.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

sodium channel activity

Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

organic acid transmembrane transporter activity

Catalysis of the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other.

secondary active transmembrane transporter activity

Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

organic cation transmembrane transporter activity

Catalysis of the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage.

channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

amiloride-sensitive sodium channel activity

NA

symporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

passive transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.

active transmembrane transporter activity

Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.

ligand-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

inorganic cation transmembrane transporter activity

Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

carboxylic acid transmembrane transporter activity

Catalysis of the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

amiloride-sensitive sodium channel activity

NA

Id	Pvalue	ExpCount	Count	Size	Term
GO:0007588	2.222e-08	0.7281	11 AQP3, ATP6V0A4, AVPR1A, CLCN5, CLDN16, DAB2, KCNJ1, KCNK5, SCNN1A, SCNN1B, SCNN1G	24	excretion
GO:0006811	3.042e-05	10.07	29 ABCC4, ATP6V0A4, CLCN5, CLDN16, CLIC3, CLIC6, EGF, GABRP, KCNJ1, KCNJ16, KCNK5, LPAR3, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC22A4, SLC26A7, SLC34A1, SLC39A9, SLC5A12, SLC5A9, TRPM6, TRPV4, WNK1, ZDHHC13	332	ion transport
GO:0006814	1.090e-03	1.426	9 SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC22A4, SLC34A1, SLC5A12, SLC5A9	47	sodium ion transport
GO:0006812	1.551e-03	6.917	20 ATP6V0A4, EGF, KCNJ1, KCNJ16, KCNK5, LPAR3, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC22A4, SLC34A1, SLC39A9, SLC5A12, SLC5A9, TRPM6, TRPV4	228	cation transport
GO:0051234	1.619e-03	32.86	55 ABCC4, AQP3, ATP6V0A4, AVPR1A, CLCN5, CLDN16, CLIC3, CLIC6, CLU, CSE1L, CUBN, CYTH1, DAB2, DPP4, EGF, FAM3D, GABRP, GHRHR, KCNJ1, KCNJ16, KCNK5, LPAR3, OSBPL3, PRLR, RAB11A, RAB19, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC25A40, SLC25A48, SLC26A7, SLC27A1, SLC34A1, SLC39A9, SLC46A1, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SNX2, TMEM9, TRPM6, TRPV4, UPK3A, WNK1, ZDHHC13	1083	establishment of localization
GO:0006810	2.336e-03	32.49	54 ABCC4, AQP3, ATP6V0A4, AVPR1A, CLCN5, CLDN16, CLIC3, CLIC6, CLU, CSE1L, CUBN, CYTH1, DAB2, EGF, FAM3D, GABRP, GHRHR, KCNJ1, KCNJ16, KCNK5, LPAR3, OSBPL3, PRLR, RAB11A, RAB19, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC25A40, SLC25A48, SLC26A7, SLC27A1, SLC34A1, SLC39A9, SLC46A1, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SNX2, TMEM9, TRPM6, TRPV4, UPK3A, WNK1, ZDHHC13	1071	transport
GO:0055085	2.510e-03	8.434	22 ABCC4, AQP3, ATP6V0A4, CLCN5, EGF, RHAG, RHCG, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC25A40, SLC25A48, SLC26A7, SLC39A9, SLC46A1, SLC5A12, SLC5A9, SLC7A9, TRPM6, TRPV4	278	transmembrane transport
GO:0015672	2.750e-03	3.398	13 ATP6V0A4, KCNJ1, KCNJ16, KCNK5, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC22A4, SLC34A1, SLC5A12, SLC5A9	112	monovalent inorganic cation transport
GO:0015849	3.396e-03	2.093	10 SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC22A4, SLC26A7, SLC27A1, SLC46A1, SLC6A19, SLC7A9	69	organic acid transport
GO:0046942	3.396e-03	2.093	10 SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC22A4, SLC26A7, SLC27A1, SLC46A1, SLC6A19, SLC7A9	69	carboxylic acid transport
GO:0046903	4.889e-03	5.825	17 AQP3, ATP6V0A4, AVPR1A, CLCN5, CLDN16, DAB2, EGF, FAM3D, GHRHR, KCNJ1, KCNK5, PRLR, SCNN1A, SCNN1B, SCNN1G, SLC22A4, TRPV4	192	secretion
GO:0030001	6.992e-03	6.037	17 EGF, KCNJ1, KCNJ16, KCNK5, LPAR3, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC22A4, SLC34A1, SLC39A9, SLC5A12, SLC5A9, TRPM6, TRPV4	199	metal ion transport
GO:0051179	9.565e-03	38.04	58 ABCC4, AQP3, ATP6V0A4, AVPR1A, CLCN5, CLDN16, CLIC3, CLIC6, CLU, CSE1L, CUBN, CYTH1, DAB2, DPP4, EGF, FAM3D, FERMT1, GABRP, GHRHR, KCNJ1, KCNJ16, KCNK5, LPAR3, MPP1, OSBPL3, PRLR, RAB11A, RAB19, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SEMA3F, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC25A40, SLC25A48, SLC26A7, SLC27A1, SLC34A1, SLC39A9, SLC46A1, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SNX2, TMEM9, TRPM6, TRPV4, UPK3A, WNK1, ZDHHC13	1254	localization
GO:0003084	1.647e-02	0.1517	3 AVPR1A, HSD11B2, WNK1	5	positive regulation of systemic arterial blood pressure
GO:0050909	2.704e-02	0.182	3 SCNN1A, SCNN1B, SCNN1G	6	sensory perception of taste
GO:0015695	4.015e-02	0.2124	3 RHAG, RHCG, SLC22A4	7	organic cation transport
GO:0032836	4.144e-02	0.06067	2 COL4A3, COL4A4	2	glomerular basement membrane development
GO:0003073	4.750e-02	0.4854	4 AQP3, AVPR1A, HSD11B2, WNK1	16	regulation of systemic arterial blood pressure

Id	Pvalue	ExpCount	Count	Size	Term
GO:0045177	5.264e-07	2.289	15 ATP6V0A4, CLCN5, CUBN, DPP4, LGMN, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC22A4, SLC46A1, SLC5A12, TRPM6, UPK3A	75	apical part of cell
GO:0016324	1.454e-06	1.801	13 ATP6V0A4, CUBN, DPP4, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC22A4, SLC46A1, SLC5A12, TRPM6, UPK3A	59	apical plasma membrane
GO:0031224	4.347e-05	49.35	78 ABCC4, ACER3, ADIPOR1, ALK, APLP2, AQP3, ATP6V0A4, AVPR1A, C2orf18, CASR, CLCN5, CLDN16, CLDN19, CLIC3, CLIC6, DPP4, EGF, FAAH, GABRP, GHRHR, GRAMD2, IFNAR1, KCNJ1, KCNJ16, KCNK5, KIAA0090, KL, KMO, LPAR3, LYPD2, LYSMD4, MARVELD3, MPP1, NCSTN, NOX4, P4HTM, PLEKHH2, PRLR, PTGER4, PTPRQ, RHAG, RHCG, RNF145, SCNN1A, SCNN1B, SCNN1G, SHISA2, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC25A40, SLC25A48, SLC26A7, SLC27A1, SLC34A1, SLC39A9, SLC46A1, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SUSD2, TMEM104, TMEM171, TMEM184C, TMEM27, TMEM9, TMPRSS13, TRPM6, TRPV4, TSHR, UPK3A, XPNPEP2, ZDHHC13, ZPLD1	1617	intrinsic to membrane
GO:0016021	8.187e-05	48.34	76 ABCC4, ACER3, ADIPOR1, ALK, APLP2, AQP3, ATP6V0A4, AVPR1A, C2orf18, CASR, CLCN5, CLDN16, CLDN19, CLIC3, CLIC6, DPP4, EGF, FAAH, GABRP, GHRHR, GRAMD2, IFNAR1, KCNJ1, KCNJ16, KCNK5, KIAA0090, KL, KMO, LPAR3, LYSMD4, MARVELD3, MPP1, NCSTN, NOX4, P4HTM, PLEKHH2, PRLR, PTGER4, PTPRQ, RHAG, RHCG, RNF145, SCNN1A, SCNN1B, SCNN1G, SHISA2, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC25A40, SLC25A48, SLC26A7, SLC27A1, SLC34A1, SLC39A9, SLC46A1, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SUSD2, TMEM104, TMEM171, TMEM184C, TMEM27, TMEM9, TMPRSS13, TRPM6, TRPV4, TSHR, UPK3A, ZDHHC13, ZPLD1	1584	integral to membrane
GO:0044459	2.452e-04	22	43 ALK, AQP3, ATP6V0A4, AVPR1A, CASR, CASS4, CLCN5, CLDN16, CLDN19, CUBN, DPP4, FERMT1, GABRP, IFNAR1, KCNJ1, KCNJ16, KCNK5, KL, LPAR3, MPP1, NCSTN, NOX4, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC22A4, SLC26A7, SLC27A1, SLC34A1, SLC46A1, SLC5A12, SLC6A19, SLC7A9, TRPM6, TRPV4, TSHR, UPK3A	721	plasma membrane part
GO:0005886	3.906e-04	34.58	58 ABCC4, ADIPOR1, ALK, APLP2, AQP3, ATP6V0A4, AVPR1A, CASR, CASS4, CLCN5, CLDN16, CLDN19, CLIC6, CUBN, CYTH1, DPP4, EGF, FERMT1, GABRP, GHRHR, IFNAR1, KCNJ1, KCNJ16, KCNK5, KL, LPAR3, LYPD2, MPP1, NCSTN, NELF, NOX4, PTGER4, RAB11A, RAB19, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC26A7, SLC27A1, SLC34A1, SLC46A1, SLC5A12, SLC5A9, SLC6A19, SLC7A9, TRPM6, TRPV4, TSHR, UPK3A, XPNPEP2	1133	plasma membrane
GO:0034706	9.692e-04	0.09156	3 SCNN1A, SCNN1B, SCNN1G	3	sodium channel complex
GO:0044425	1.277e-03	57.96	82 ABCC4, ACER3, ADIPOR1, ALK, APLP2, AQP3, ATP6V0A4, AVPR1A, C2orf18, CASR, CASS4, CLCN5, CLDN16, CLDN19, CLIC3, CLIC6, CUBN, DAB2, DPP4, EGF, FAAH, FERMT1, GABRP, GHRHR, GRAMD2, IFNAR1, KCNJ1, KCNJ16, KCNK5, KIAA0090, KL, KMO, LPAR3, LYPD2, LYSMD4, MARVELD3, MPP1, NCSTN, NOX4, P4HTM, PLEKHH2, PRLR, PTGER4, PTPRQ, RHAG, RHCG, RNF145, SCNN1A, SCNN1B, SCNN1G, SHISA2, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC25A40, SLC25A48, SLC26A7, SLC27A1, SLC34A1, SLC39A9, SLC46A1, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SUSD2, TMEM104, TMEM171, TMEM184C, TMEM27, TMEM9, TMPRSS13, TRPM6, TRPV4, TSHR, UPK3A, XPNPEP2, ZDHHC13, ZPLD1	1899	membrane part
GO:0031526	1.009e-02	0.3967	4 ATP6V0A4, CUBN, SLC34A1, TRPM6	13	brush border membrane
GO:0016020	1.909e-02	71.02	90 ABCC4, ACER3, ADIPOR1, ALK, APLP2, AQP3, ATP6V0A4, AVPR1A, C2orf18, CASR, CASS4, CLCN5, CLDN16, CLDN19, CLIC3, CLIC6, CUBN, CYTH1, DAB2, DPP4, EGF, FAAH, FERMT1, GABRP, GHRHR, GRAMD2, IFNAR1, KCNJ1, KCNJ16, KCNK5, KIAA0090, KL, KMO, LAMC3, LPAR3, LYPD2, LYSMD4, MARVELD3, MPP1, NCSTN, NELF, NOX4, P4HTM, PLEKHH2, PRLR, PTGER4, PTPRQ, RAB11A, RAB19, RHAG, RHCG, RNF145, SCNN1A, SCNN1B, SCNN1G, SEMA3F, SHISA2, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC25A40, SLC25A48, SLC26A7, SLC27A1, SLC34A1, SLC39A9, SLC46A1, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SUSD2, TFCP2L1, TMEM104, TMEM171, TMEM184C, TMEM27, TMEM9, TMPRSS13, TRPM6, TRPV4, TSHR, UPK3A, VAC14, XPNPEP2, ZDHHC13, ZPLD1	2327	membrane
GO:0031253	2.839e-02	1.312	6 ATP6V0A4, CUBN, DPP4, FERMT1, SLC34A1, TRPM6	43	cell projection membrane
GO:0005773	2.913e-02	2.808	9 AMBRA1, ASAH1, ATP6V0A4, C2orf18, CUBN, LGMN, NAGA, NCSTN, TMEM9	92	vacuole
GO:0005903	2.937e-02	0.5493	4 ATP6V0A4, CUBN, SLC34A1, TRPM6	18	brush border
GO:0005887	4.420e-02	12.6	23 ALK, AVPR1A, CASR, CLCN5, IFNAR1, KCNJ1, KCNJ16, KCNK5, KL, LPAR3, MPP1, NCSTN, RHAG, RHCG, SCNN1G, SLC10A2, SLC16A2, SLC16A4, SLC22A4, SLC34A1, SLC6A19, SLC7A9, TSHR	413	integral to plasma membrane

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005215	1.389e-06	13.66	38 ABCC4, AQP3, ATP6V0A4, CLCN5, CLDN16, CLIC3, CLIC6, CSE1L, CUBN, GABRP, KCNJ1, KCNJ16, KCNK5, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC25A48, SLC26A7, SLC27A1, SLC34A1, SLC39A9, SLC46A1, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SNX2, TRPM6, TRPV4, ZDHHC13	454	transporter activity
GO:0022857	3.149e-06	11.07	33 ABCC4, AQP3, ATP6V0A4, CLCN5, CLDN16, CLIC3, CLIC6, GABRP, KCNJ1, KCNJ16, KCNK5, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC26A7, SLC34A1, SLC39A9, SLC46A1, SLC5A12, SLC5A9, SLC6A19, SLC7A9, TRPM6, TRPV4, ZDHHC13	368	transmembrane transporter activity
GO:0022892	9.156e-06	11.67	33 ABCC4, AQP3, ATP6V0A4, CLCN5, CLDN16, CLIC3, CLIC6, CSE1L, GABRP, KCNJ1, KCNJ16, KCNK5, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC22A4, SLC26A7, SLC27A1, SLC34A1, SLC39A9, SLC5A9, SLC6A19, SLC7A9, SNX2, TRPM6, TRPV4, ZDHHC13	388	substrate-specific transporter activity
GO:0022891	1.876e-05	10.29	30 ABCC4, AQP3, ATP6V0A4, CLCN5, CLDN16, CLIC3, CLIC6, GABRP, KCNJ1, KCNJ16, KCNK5, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC22A4, SLC26A7, SLC34A1, SLC39A9, SLC5A9, SLC6A19, SLC7A9, TRPM6, TRPV4, ZDHHC13	342	substrate-specific transmembrane transporter activity
GO:0015075	1.291e-04	9.024	26 ABCC4, ATP6V0A4, CLCN5, CLDN16, CLIC3, CLIC6, GABRP, KCNJ1, KCNJ16, KCNK5, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC22A4, SLC26A7, SLC34A1, SLC39A9, SLC5A9, SLC6A19, TRPM6, TRPV4, ZDHHC13	300	ion transmembrane transporter activity
GO:0015293	6.205e-04	1.684	10 SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC34A1, SLC5A12, SLC5A9, SLC6A19	56	symporter activity
GO:0015291	7.424e-04	2.527	12 CLCN5, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC26A7, SLC34A1, SLC5A12, SLC5A9, SLC6A19	84	secondary active transmembrane transporter activity
GO:0022804	7.556e-04	3.91	15 ABCC4, ATP6V0A4, CLCN5, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC22A4, SLC26A7, SLC34A1, SLC5A12, SLC5A9, SLC6A19, SLC7A9	130	active transmembrane transporter activity
GO:0008324	3.197e-03	6.828	19 ATP6V0A4, CLDN16, KCNJ1, KCNJ16, KCNK5, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC22A4, SLC39A9, SLC5A9, SLC6A19, TRPM6, TRPV4, ZDHHC13	227	cation transmembrane transporter activity
GO:0022890	5.897e-03	2.316	10 ATP6V0A4, CLDN16, RHAG, RHCG, SLC10A2, SLC13A3, SLC22A4, SLC5A9, SLC6A19, ZDHHC13	77	inorganic cation transmembrane transporter activity
GO:0015101	6.806e-03	0.1203	3 RHAG, RHCG, SLC22A4	4	organic cation transmembrane transporter activity
GO:0015280	6.806e-03	0.1203	3 SCNN1A, SCNN1B, SCNN1G	4	amiloride-sensitive sodium channel activity
GO:0005342	8.185e-03	1.173	7 SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC26A7, SLC6A19, SLC7A9	39	organic acid transmembrane transporter activity
GO:0046943	8.185e-03	1.173	7 SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC26A7, SLC6A19, SLC7A9	39	carboxylic acid transmembrane transporter activity
GO:0022838	1.471e-02	5.414	15 ABCC4, AQP3, CLCN5, CLIC3, CLIC6, GABRP, KCNJ1, KCNJ16, KCNK5, SCNN1A, SCNN1B, SCNN1G, SLC26A7, TRPM6, TRPV4	180	substrate-specific channel activity
GO:0015267	2.069e-02	5.655	15 ABCC4, AQP3, CLCN5, CLIC3, CLIC6, GABRP, KCNJ1, KCNJ16, KCNK5, SCNN1A, SCNN1B, SCNN1G, SLC26A7, TRPM6, TRPV4	188	channel activity
GO:0022803	2.069e-02	5.655	15 ABCC4, AQP3, CLCN5, CLIC3, CLIC6, GABRP, KCNJ1, KCNJ16, KCNK5, SCNN1A, SCNN1B, SCNN1G, SLC26A7, TRPM6, TRPV4	188	passive transmembrane transporter activity
GO:0050699	2.217e-02	0.1805	3 SCNN1A, SCNN1B, SCNN1G	6	WW domain binding
GO:0008509	2.713e-02	1.955	8 ABCC4, CLCN5, CLIC3, CLIC6, GABRP, SLC13A3, SLC26A7, SLC34A1	65	anion transmembrane transporter activity
GO:0005216	2.971e-02	5.294	14 ABCC4, CLCN5, CLIC3, CLIC6, GABRP, KCNJ1, KCNJ16, KCNK5, SCNN1A, SCNN1B, SCNN1G, SLC26A7, TRPM6, TRPV4	176	ion channel activity
GO:0005254	3.257e-02	1.143	6 ABCC4, CLCN5, CLIC3, CLIC6, GABRP, SLC26A7	38	chloride channel activity
GO:0008519	3.444e-02	0.06016	2 RHAG, RHCG	2	ammonium transmembrane transporter activity
GO:0015095	3.444e-02	0.06016	2 CLDN16, ZDHHC13	2	magnesium ion transmembrane transporter activity
GO:0005253	3.603e-02	1.173	6 ABCC4, CLCN5, CLIC3, CLIC6, GABRP, SLC26A7	39	anion channel activity
GO:0046873	4.422e-02	1.684	7 CLDN16, SLC10A2, SLC13A3, SLC39A9, SLC5A9, SLC6A19, ZDHHC13	56	metal ion transmembrane transporter activity

Id	Pvalue	ExpCount	Count	Size	Term
04960	4.187e-03	0.4632	5 HSD11B2, KCNJ1, SCNN1A, SCNN1B, SCNN1G	16	Aldosterone-regulated sodium reabsorption

No enriched terms

No enriched terms

Entrez genes

ABCC4ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ENSG00000125257), score: 0.54 ACER3alkaline ceramidase 3 (ENSG00000078124), score: 0.61 ADIPOR1adiponectin receptor 1 (ENSG00000159346), score: 0.53 ALKanaplastic lymphoma receptor tyrosine kinase (ENSG00000171094), score: 0.58 AMBRA1autophagy/beclin-1 regulator 1 (ENSG00000110497), score: 0.49 ANAPC4anaphase promoting complex subunit 4 (ENSG00000053900), score: -0.57 ANKRD2ankyrin repeat domain 2 (stretch responsive muscle) (ENSG00000165887), score: 0.55 APLP2amyloid beta (A4) precursor-like protein 2 (ENSG00000084234), score: 0.58 AQP3aquaporin 3 (Gill blood group) (ENSG00000165272), score: 0.56 ARHGEF38Rho guanine nucleotide exchange factor (GEF) 38 (ENSG00000138784), score: 0.52 ARSKarylsulfatase family, member K (ENSG00000164291), score: 0.62 ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 1 (ENSG00000104763), score: 0.77 ASPAaspartoacylase (ENSG00000108381), score: 0.72 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.61 AVPR1Aarginine vasopressin receptor 1A (ENSG00000166148), score: 0.5 C1orf116chromosome 1 open reading frame 116 (ENSG00000182795), score: 0.54 C2orf18chromosome 2 open reading frame 18 (ENSG00000213699), score: 0.6 C8orf42chromosome 8 open reading frame 42 (ENSG00000180190), score: 0.58 CASRcalcium-sensing receptor (ENSG00000036828), score: 0.7 CASS4Cas scaffolding protein family member 4 (ENSG00000087589), score: 0.6 CCNHcyclin H (ENSG00000134480), score: -0.64 CDC123cell division cycle 123 homolog (S. cerevisiae) (ENSG00000151465), score: -0.49 CLCN5chloride channel 5 (ENSG00000171365), score: 0.61 CLDN16claudin 16 (ENSG00000113946), score: 0.58 CLDN19claudin 19 (ENSG00000164007), score: 0.84 CLIC3chloride intracellular channel 3 (ENSG00000169583), score: 0.5 CLIC6chloride intracellular channel 6 (ENSG00000159212), score: 0.85 CLUclusterin (ENSG00000120885), score: -0.48 COL4A3collagen, type IV, alpha 3 (Goodpasture antigen) (ENSG00000169031), score: 0.67 COL4A4collagen, type IV, alpha 4 (ENSG00000081052), score: 0.72 CSE1LCSE1 chromosome segregation 1-like (yeast) (ENSG00000124207), score: -0.49 CUBNcubilin (intrinsic factor-cobalamin receptor) (ENSG00000107611), score: 0.66 CYTH1cytohesin 1 (ENSG00000108669), score: -0.49 DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (ENSG00000153071), score: 0.59 DAOD-amino-acid oxidase (ENSG00000110887), score: 0.54 DHDPSLdihydrodipicolinate synthase-like, mitochondrial (ENSG00000241935), score: 0.52 DPP4dipeptidyl-peptidase 4 (ENSG00000197635), score: 0.52 EGFepidermal growth factor (ENSG00000138798), score: 0.53 EHFets homologous factor (ENSG00000135373), score: 0.49 EPYCepiphycan (ENSG00000083782), score: 0.54 ESRP1epithelial splicing regulatory protein 1 (ENSG00000104413), score: 0.51 FAAHfatty acid amide hydrolase (ENSG00000117480), score: 0.59 FAM3Dfamily with sequence similarity 3, member D (ENSG00000198643), score: 0.65 FAM83Bfamily with sequence similarity 83, member B (ENSG00000168143), score: 0.76 FBXO4F-box protein 4 (ENSG00000151876), score: 0.59 FERMT1fermitin family member 1 (ENSG00000101311), score: 0.55 FOXI1forkhead box I1 (ENSG00000168269), score: 0.55 FSHBfollicle stimulating hormone, beta polypeptide (ENSG00000131808), score: 0.94 GABRPgamma-aminobutyric acid (GABA) A receptor, pi (ENSG00000094755), score: 0.62 GALK2galactokinase 2 (ENSG00000156958), score: 0.57 GATA3GATA binding protein 3 (ENSG00000107485), score: 0.53 GCM1glial cells missing homolog 1 (Drosophila) (ENSG00000137270), score: 0.6 GHRHRgrowth hormone releasing hormone receptor (ENSG00000106128), score: 0.51 GRAMD2GRAM domain containing 2 (ENSG00000175318), score: 0.49 GSCgoosecoid homeobox (ENSG00000133937), score: 0.63 HNF4Ghepatocyte nuclear factor 4, gamma (ENSG00000164749), score: 0.5 HOXB7homeobox B7 (ENSG00000120087), score: 0.59 HOXD10homeobox D10 (ENSG00000128710), score: 0.61 HOXD4homeobox D4 (ENSG00000170166), score: 0.53 HSD11B2hydroxysteroid (11-beta) dehydrogenase 2 (ENSG00000176387), score: 0.56 IFNAR1interferon (alpha, beta and omega) receptor 1 (ENSG00000142166), score: -0.49 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.52 KCNJ16potassium inwardly-rectifying channel, subfamily J, member 16 (ENSG00000153822), score: 0.51 KCNK5potassium channel, subfamily K, member 5 (ENSG00000164626), score: 0.49 KIAA0090KIAA0090 (ENSG00000127463), score: 0.54 KLklotho (ENSG00000133116), score: 0.53 KLF12Kruppel-like factor 12 (ENSG00000118922), score: -0.54 KLHL8kelch-like 8 (Drosophila) (ENSG00000145332), score: 0.63 KMOkynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (ENSG00000117009), score: 0.5 KRT23keratin 23 (histone deacetylase inducible) (ENSG00000108244), score: 0.53 LAMC3laminin, gamma 3 (ENSG00000050555), score: 0.55 LGALS2lectin, galactoside-binding, soluble, 2 (ENSG00000100079), score: 0.57 LGMNlegumain (ENSG00000100600), score: 0.7 LPAR3lysophosphatidic acid receptor 3 (ENSG00000171517), score: 0.55 LRRC58leucine rich repeat containing 58 (ENSG00000163428), score: 0.55 LXNlatexin (ENSG00000079257), score: 0.53 LYPD2LY6/PLAUR domain containing 2 (ENSG00000197353), score: 1 LYSMD4LysM, putative peptidoglycan-binding, domain containing 4 (ENSG00000183060), score: -0.54 MARVELD3MARVEL domain containing 3 (ENSG00000140832), score: 0.54 MPP1membrane protein, palmitoylated 1, 55kDa (ENSG00000130830), score: 0.67 MSRAmethionine sulfoxide reductase A (ENSG00000175806), score: 0.53 MYBv-myb myeloblastosis viral oncogene homolog (avian) (ENSG00000118513), score: 0.5 NAGAN-acetylgalactosaminidase, alpha- (ENSG00000198951), score: 0.61 NCSTNnicastrin (ENSG00000162736), score: 0.58 NELFnasal embryonic LHRH factor (ENSG00000165802), score: -0.51 NOX4NADPH oxidase 4 (ENSG00000086991), score: 0.58 OSBPL3oxysterol binding protein-like 3 (ENSG00000070882), score: 0.51 P4HTMprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) (ENSG00000178467), score: -0.49 PAFAH2platelet-activating factor acetylhydrolase 2, 40kDa (ENSG00000158006), score: 0.49 PGM3phosphoglucomutase 3 (ENSG00000013375), score: 0.74 PLEKHF2pleckstrin homology domain containing, family F (with FYVE domain) member 2 (ENSG00000175895), score: 0.59 PLEKHH2pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 (ENSG00000152527), score: 0.51 PLS1plastin 1 (ENSG00000120756), score: 0.56 PRLRprolactin receptor (ENSG00000113494), score: 0.61 PTGER4prostaglandin E receptor 4 (subtype EP4) (ENSG00000171522), score: 0.56 PTPRQprotein tyrosine phosphatase, receptor type, Q (ENSG00000139304), score: 0.53 PYROXD2pyridine nucleotide-disulphide oxidoreductase domain 2 (ENSG00000119943), score: 0.67 RAB11ARAB11A, member RAS oncogene family (ENSG00000103769), score: 0.51 RAB19RAB19, member RAS oncogene family (ENSG00000146955), score: 0.49 RAVER2ribonucleoprotein, PTB-binding 2 (ENSG00000162437), score: 0.51 RHAGRh-associated glycoprotein (ENSG00000112077), score: 0.78 RHCGRh family, C glycoprotein (ENSG00000140519), score: 0.56 RNF145ring finger protein 145 (ENSG00000145860), score: -0.52 SCNN1Asodium channel, nonvoltage-gated 1 alpha (ENSG00000111319), score: 0.53 SCNN1Bsodium channel, nonvoltage-gated 1, beta (ENSG00000168447), score: 0.57 SCNN1Gsodium channel, nonvoltage-gated 1, gamma (ENSG00000166828), score: 0.58 SDSLserine dehydratase-like (ENSG00000139410), score: 0.53 SEMA3Fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F (ENSG00000001617), score: 0.49 SETD7SET domain containing (lysine methyltransferase) 7 (ENSG00000145391), score: -0.52 SH3BP5SH3-domain binding protein 5 (BTK-associated) (ENSG00000131370), score: 0.75 SHISA2shisa homolog 2 (Xenopus laevis) (ENSG00000180730), score: 0.49 SIM1single-minded homolog 1 (Drosophila) (ENSG00000112246), score: 0.67 SLC10A2solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (ENSG00000125255), score: 0.68 SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (ENSG00000158296), score: 0.5 SLC16A12solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (ENSG00000152779), score: 0.5 SLC16A2solute carrier family 16, member 2 (monocarboxylic acid transporter 8) (ENSG00000147100), score: 0.56 SLC16A4solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (ENSG00000168679), score: 0.58 SLC22A4solute carrier family 22 (organic cation/ergothioneine transporter), member 4 (ENSG00000197208), score: 0.5 SLC25A40solute carrier family 25, member 40 (ENSG00000075303), score: 0.5 SLC25A48solute carrier family 25, member 48 (ENSG00000145832), score: 0.53 SLC26A7solute carrier family 26, member 7 (ENSG00000147606), score: 0.51 SLC27A1solute carrier family 27 (fatty acid transporter), member 1 (ENSG00000130304), score: 0.7 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 0.68 SLC39A9solute carrier family 39 (zinc transporter), member 9 (ENSG00000029364), score: 0.56 SLC46A1solute carrier family 46 (folate transporter), member 1 (ENSG00000076351), score: 0.53 SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12 (ENSG00000148942), score: 0.65 SLC5A9solute carrier family 5 (sodium/glucose cotransporter), member 9 (ENSG00000117834), score: 0.62 SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19 (ENSG00000174358), score: 0.67 SLC7A9solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 (ENSG00000021488), score: 0.52 SNX2sorting nexin 2 (ENSG00000205302), score: 0.53 SRMSsrc-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (ENSG00000125508), score: 0.6 SS18synovial sarcoma translocation, chromosome 18 (ENSG00000141380), score: 0.6 STC1stanniocalcin 1 (ENSG00000159167), score: 0.56 SUSD2sushi domain containing 2 (ENSG00000099994), score: 0.58 SYDE2synapse defective 1, Rho GTPase, homolog 2 (C. elegans) (ENSG00000097096), score: 0.55 TARSL2threonyl-tRNA synthetase-like 2 (ENSG00000185418), score: -0.49 TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma) (ENSG00000087510), score: 0.54 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.49 TINAGtubulointerstitial nephritis antigen (ENSG00000137251), score: 0.49 TMEM104transmembrane protein 104 (ENSG00000109066), score: 0.51 TMEM171transmembrane protein 171 (ENSG00000157111), score: 0.57 TMEM184Ctransmembrane protein 184C (ENSG00000164168), score: 0.53 TMEM27transmembrane protein 27 (ENSG00000147003), score: 0.64 TMEM9transmembrane protein 9 (ENSG00000116857), score: -0.56 TMPRSS13transmembrane protease, serine 13 (ENSG00000137747), score: 0.59 TRAF3TNF receptor-associated factor 3 (ENSG00000131323), score: -0.54 TRPM6transient receptor potential cation channel, subfamily M, member 6 (ENSG00000119121), score: 0.7 TRPV4transient receptor potential cation channel, subfamily V, member 4 (ENSG00000111199), score: 0.52 TSHRthyroid stimulating hormone receptor (ENSG00000165409), score: 0.59 UPK3Auroplakin 3A (ENSG00000100373), score: 0.66 VAC14Vac14 homolog (S. cerevisiae) (ENSG00000103043), score: 0.53 WNK1WNK lysine deficient protein kinase 1 (ENSG00000060237), score: 0.67 WNT16wingless-type MMTV integration site family, member 16 (ENSG00000002745), score: 0.54 XPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (ENSG00000108039), score: 0.56 XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (ENSG00000122121), score: 0.51 ZBED4zinc finger, BED-type containing 4 (ENSG00000100426), score: 0.6 ZDHHC13zinc finger, DHHC-type containing 13 (ENSG00000177054), score: 0.61 ZPLD1zona pellucida-like domain containing 1 (ENSG00000170044), score: 0.68

Non-Entrez genes

Unknown, score:

Id	species	tissue	sex	individual
oan_kd_m_ca1	oan	kd	m	_
mdo_kd_m_ca1	mdo	kd	m	_
mdo_kd_f_ca1	mdo	kd	f	_
oan_kd_f_ca1	oan	kd	f	_