Under-expression is coded with green,
over-expression with red color.
system process
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
transport
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.
ion transport
The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.
cation transport
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.
potassium ion transport
The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore.
metal ion transport
The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.
cell communication
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
cell surface receptor linked signaling pathway
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
G-protein coupled receptor protein signaling pathway
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
cell-cell signaling
Any process that mediates the transfer of information from one cell to another.
synaptic transmission
The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
nervous system development
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
neurological system process
A organ system process carried out by any of the organs or tissues of neurological system.
behavior
The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
learning or memory
The acquisition and processing of information and/or the storage and retrieval of this information over time.
learning
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
memory
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
associative learning
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of cell communication
Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
monovalent inorganic cation transport
The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.
transmission of nerve impulse
The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.
signaling pathway
The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.
signaling process
Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.
signaling
The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.
signal transmission
The process whereby a signal is released and/or conveyed from one location to another.
regulation of neurological system process
Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
regulation of system process
Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
regulation of synaptic plasticity
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
regulation of neuronal synaptic plasticity
A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of synaptic transmission
Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
cognition
The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
response to stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
localization
Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
regulation of transmission of nerve impulse
Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
regulation of biological quality
Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
all
NA
signaling process
Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
cell-cell signaling
Any process that mediates the transfer of information from one cell to another.
regulation of cell communication
Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
transmission of nerve impulse
The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.
regulation of system process
Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
synaptic transmission
The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
regulation of transmission of nerve impulse
Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
transmission of nerve impulse
The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.
regulation of neurological system process
Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system.
regulation of synaptic transmission
Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
regulation of synaptic plasticity
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
regulation of transmission of nerve impulse
Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
learning or memory
The acquisition and processing of information and/or the storage and retrieval of this information over time.
potassium ion transport
The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
cytoskeleton
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
voltage-gated potassium channel complex
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
postsynaptic density
The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.
cell junction
A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
axon
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
dendrite
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
intrinsic to membrane
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
axon part
A part of an axon, a cell projection of a neuron.
ion channel complex
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
cation channel complex
An ion channel complex through which cations pass.
potassium channel complex
An ion channel complex through which potassium ions pass.
presynaptic membrane
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
cell projection
A prolongation or process extending from a cell, e.g. a flagellum or axon.
neuron projection
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
dendritic spine
Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
protein complex
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.
axon terminus
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
neuron projection terminus
The specialized, terminal region of a neuron projection such as an axon or a dendrite.
neuron spine
A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
synapse part
Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell projection part
Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
synapse
The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
postsynaptic membrane
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.
all
NA
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
synapse part
Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
presynaptic membrane
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
postsynaptic membrane
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.
cell projection part
Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
ion channel complex
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
postsynaptic density
The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
neuron projection terminus
The specialized, terminal region of a neuron projection such as an axon or a dendrite.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
axon terminus
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
axon part
A part of an axon, a cell projection of a neuron.
dendritic spine
Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.
dendritic spine
Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.
ion channel complex
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
voltage-gated potassium channel complex
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
voltage-gated potassium channel complex
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
transporter activity
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
ion channel activity
Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
voltage-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons.
voltage-gated potassium channel activity
Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel.
cation channel activity
Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.
potassium channel activity
Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
transmembrane transporter activity
Enables the transfer of a substance from one side of a membrane to the other.
cation transmembrane transporter activity
Catalysis of the transfer of cation from one side of the membrane to the other.
ion transmembrane transporter activity
Catalysis of the transfer of an ion from one side of a membrane to the other.
channel activity
Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
ligand-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
passive transmembrane transporter activity
Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.
voltage-gated channel activity
Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
ligand-gated channel activity
Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
gated channel activity
Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.
substrate-specific channel activity
Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
voltage-gated cation channel activity
Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion.
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
substrate-specific transporter activity
Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
all
NA
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
substrate-specific channel activity
Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
ion channel activity
Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
cation channel activity
Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.
voltage-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons.
ligand-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
voltage-gated cation channel activity
Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion.
voltage-gated potassium channel activity
Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel.
Id | Pvalue | ExpCount | Count | Size | Term |
---|---|---|---|---|---|
04080 | 6.813e-05 | 2.153 | 12 | 102 | Neuroactive ligand-receptor interaction |
04020 | 6.539e-04 | 1.435 | 9 | 68 | Calcium signaling pathway |
04971 | 2.072e-03 | 0.6333 | 6 | 30 | Gastric acid secretion |
04970 | 3.797e-03 | 0.4433 | 5 | 21 | Salivary secretion |
ADCY2adenylate cyclase 2 (brain) (ENSG00000078295), score: 0.78 ANO3anoctamin 3 (ENSG00000134343), score: 0.86 ARCactivity-regulated cytoskeleton-associated protein (ENSG00000198576), score: 0.85 ARHGAP32Rho GTPase activating protein 32 (ENSG00000134909), score: 0.81 ATP2B1ATPase, Ca++ transporting, plasma membrane 1 (ENSG00000070961), score: 0.77 ATRNL1attractin-like 1 (ENSG00000107518), score: 0.78 BAI1brain-specific angiogenesis inhibitor 1 (ENSG00000181790), score: 0.81 BCL11BB-cell CLL/lymphoma 11B (zinc finger protein) (ENSG00000127152), score: 0.92 C13orf36chromosome 13 open reading frame 36 (ENSG00000180440), score: 0.9 C20orf103chromosome 20 open reading frame 103 (ENSG00000125869), score: 0.78 C8orf46chromosome 8 open reading frame 46 (ENSG00000169085), score: 0.8 CACNA1Ecalcium channel, voltage-dependent, R type, alpha 1E subunit (ENSG00000198216), score: 0.82 CACNG3calcium channel, voltage-dependent, gamma subunit 3 (ENSG00000006116), score: 0.88 CAMK1Gcalcium/calmodulin-dependent protein kinase IG (ENSG00000008118), score: 0.83 CAMK2Acalcium/calmodulin-dependent protein kinase II alpha (ENSG00000070808), score: 0.87 CBLN4cerebellin 4 precursor (ENSG00000054803), score: 0.93 CDH10cadherin 10, type 2 (T2-cadherin) (ENSG00000040731), score: 0.79 CDH12cadherin 12, type 2 (N-cadherin 2) (ENSG00000154162), score: 0.83 CDH9cadherin 9, type 2 (T1-cadherin) (ENSG00000113100), score: 0.88 CHN1chimerin (chimaerin) 1 (ENSG00000128656), score: 0.79 CHRM3cholinergic receptor, muscarinic 3 (ENSG00000133019), score: 0.94 CHST1carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 (ENSG00000175264), score: 0.8 CNIH3cornichon homolog 3 (Drosophila) (ENSG00000143786), score: 0.81 CNTN3contactin 3 (plasmacytoma associated) (ENSG00000113805), score: 0.85 CPNE4copine IV (ENSG00000196353), score: 0.82 CRHcorticotropin releasing hormone (ENSG00000147571), score: 0.81 DCLK1doublecortin-like kinase 1 (ENSG00000133083), score: 0.81 DLGAP2discs, large (Drosophila) homolog-associated protein 2 (ENSG00000198010), score: 0.89 DLX1distal-less homeobox 1 (ENSG00000144355), score: 0.96 DRP2dystrophin related protein 2 (ENSG00000102385), score: 0.84 DSCAMDown syndrome cell adhesion molecule (ENSG00000171587), score: 0.86 ELFN2extracellular leucine-rich repeat and fibronectin type III domain containing 2 (ENSG00000166897), score: 0.85 ENC1ectodermal-neural cortex 1 (with BTB-like domain) (ENSG00000171617), score: 0.91 EPHA5EPH receptor A5 (ENSG00000145242), score: 0.84 EPHX4epoxide hydrolase 4 (ENSG00000172031), score: 0.83 FAM19A1family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 (ENSG00000183662), score: 0.99 FAM49Afamily with sequence similarity 49, member A (ENSG00000197872), score: 0.81 FAM5Bfamily with sequence similarity 5, member B (ENSG00000198797), score: 0.86 FAM5Cfamily with sequence similarity 5, member C (ENSG00000162670), score: 0.79 FAM81Afamily with sequence similarity 81, member A (ENSG00000157470), score: 0.79 FEZF2FEZ family zinc finger 2 (ENSG00000153266), score: 0.96 FLRT2fibronectin leucine rich transmembrane protein 2 (ENSG00000185070), score: 0.8 FOXG1forkhead box G1 (ENSG00000176165), score: 0.88 FRMPD4FERM and PDZ domain containing 4 (ENSG00000169933), score: 0.79 GABRA2gamma-aminobutyric acid (GABA) A receptor, alpha 2 (ENSG00000151834), score: 0.77 GABRB3gamma-aminobutyric acid (GABA) A receptor, beta 3 (ENSG00000166206), score: 0.77 GLRA3glycine receptor, alpha 3 (ENSG00000145451), score: 0.96 GPR123G protein-coupled receptor 123 (ENSG00000197177), score: 0.83 GRIA3glutamate receptor, ionotrophic, AMPA 3 (ENSG00000125675), score: 0.82 GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A (ENSG00000183454), score: 0.8 GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B (ENSG00000150086), score: 0.84 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (ENSG00000102468), score: 0.94 HTR45-hydroxytryptamine (serotonin) receptor 4 (ENSG00000164270), score: 0.88 KCNA4potassium voltage-gated channel, shaker-related subfamily, member 4 (ENSG00000182255), score: 0.83 KCNA6potassium voltage-gated channel, shaker-related subfamily, member 6 (ENSG00000151079), score: 0.85 KCNF1potassium voltage-gated channel, subfamily F, member 1 (ENSG00000162975), score: 0.92 KCNG3potassium voltage-gated channel, subfamily G, member 3 (ENSG00000171126), score: 0.86 KCNK2potassium channel, subfamily K, member 2 (ENSG00000082482), score: 0.87 KCNQ3potassium voltage-gated channel, KQT-like subfamily, member 3 (ENSG00000184156), score: 0.87 KCNQ5potassium voltage-gated channel, KQT-like subfamily, member 5 (ENSG00000185760), score: 0.97 KCNS1potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 (ENSG00000124134), score: 0.98 KCNS2potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 (ENSG00000156486), score: 0.99 KCTD16potassium channel tetramerisation domain containing 16 (ENSG00000183775), score: 0.82 KCTD4potassium channel tetramerisation domain containing 4 (ENSG00000180332), score: 0.88 LINGO2leucine rich repeat and Ig domain containing 2 (ENSG00000174482), score: 0.82 LMO4LIM domain only 4 (ENSG00000143013), score: 0.84 LMTK2lemur tyrosine kinase 2 (ENSG00000164715), score: 0.78 LPPR3lipid phosphate phosphatase-related protein type 3 (ENSG00000129951), score: 0.83 LPPR4lipid phosphate phosphatase-related protein type 4 (ENSG00000117600), score: 0.88 LRFN2leucine rich repeat and fibronectin type III domain containing 2 (ENSG00000156564), score: 0.88 LRFN5leucine rich repeat and fibronectin type III domain containing 5 (ENSG00000165379), score: 0.79 LRRC4Cleucine rich repeat containing 4C (ENSG00000148948), score: 0.82 LRRC7leucine rich repeat containing 7 (ENSG00000033122), score: 0.88 LRTM2leucine-rich repeats and transmembrane domains 2 (ENSG00000166159), score: 0.82 MATKmegakaryocyte-associated tyrosine kinase (ENSG00000007264), score: 0.77 MC4Rmelanocortin 4 receptor (ENSG00000166603), score: 0.8 MEF2Cmyocyte enhancer factor 2C (ENSG00000081189), score: 0.86 MGAT5Bmannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B (ENSG00000167889), score: 0.81 MKL2MKL/myocardin-like 2 (ENSG00000186260), score: 0.93 NECAB1N-terminal EF-hand calcium binding protein 1 (ENSG00000123119), score: 0.84 NETO1neuropilin (NRP) and tolloid (TLL)-like 1 (ENSG00000166342), score: 1 NGEFneuronal guanine nucleotide exchange factor (ENSG00000066248), score: 0.79 NPY2Rneuropeptide Y receptor Y2 (ENSG00000185149), score: 0.82 PCDH19protocadherin 19 (ENSG00000165194), score: 0.89 PCDH20protocadherin 20 (ENSG00000197991), score: 0.88 PCSK1proprotein convertase subtilisin/kexin type 1 (ENSG00000175426), score: 0.93 PDE8Bphosphodiesterase 8B (ENSG00000113231), score: 0.82 PEX5Lperoxisomal biogenesis factor 5-like (ENSG00000114757), score: 0.78 PLCB1phospholipase C, beta 1 (phosphoinositide-specific) (ENSG00000182621), score: 0.88 PPFIA2protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 (ENSG00000139220), score: 0.77 PRICKLE2prickle homolog 2 (Drosophila) (ENSG00000163637), score: 0.85 PRKG2protein kinase, cGMP-dependent, type II (ENSG00000138669), score: 0.83 RORBRAR-related orphan receptor B (ENSG00000198963), score: 0.87 RSPO2R-spondin 2 homolog (Xenopus laevis) (ENSG00000147655), score: 0.92 RXFP1relaxin/insulin-like family peptide receptor 1 (ENSG00000171509), score: 0.79 SATB2SATB homeobox 2 (ENSG00000119042), score: 0.82 SCG2secretogranin II (ENSG00000171951), score: 0.79 SCN3Bsodium channel, voltage-gated, type III, beta (ENSG00000166257), score: 0.8 SERPINI1serpin peptidase inhibitor, clade I (neuroserpin), member 1 (ENSG00000163536), score: 0.8 SLC24A4solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 (ENSG00000140090), score: 0.87 SLC6A7solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 (ENSG00000011083), score: 0.78 SNTG1syntrophin, gamma 1 (ENSG00000147481), score: 0.9 SSTsomatostatin (ENSG00000157005), score: 0.92 ST6GALNAC5ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ENSG00000117069), score: 0.91 SYT17synaptotagmin XVII (ENSG00000103528), score: 0.8 TAC1tachykinin, precursor 1 (ENSG00000006128), score: 0.82 TOXthymocyte selection-associated high mobility group box (ENSG00000198846), score: 0.77 TRPC5transient receptor potential cation channel, subfamily C, member 5 (ENSG00000072315), score: 0.78 UNC5Aunc-5 homolog A (C. elegans) (ENSG00000113763), score: 0.77 UNC5Dunc-5 homolog D (C. elegans) (ENSG00000156687), score: 0.83 VIPvasoactive intestinal peptide (ENSG00000146469), score: 0.88 VSTM2AV-set and transmembrane domain containing 2A (ENSG00000170419), score: 0.86 VWC2Lvon Willebrand factor C domain-containing protein 2-like (ENSG00000174453), score: 0.85 WDR7WD repeat domain 7 (ENSG00000091157), score: 0.81 ZDHHC22zinc finger, DHHC-type containing 22 (ENSG00000177108), score: 0.86 ZMAT4zinc finger, matrin type 4 (ENSG00000165061), score: 0.81 ZNF365zinc finger protein 365 (ENSG00000138311), score: 0.79
Id | species | tissue | sex | individual |
---|---|---|---|---|
ggo_br_m_ca1 | ggo | br | m | _ |
mdo_br_f_ca1 | mdo | br | f | _ |
mmu_br_m2_ca1 | mmu | br | m | 2 |
ptr_br_m5_ca1 | ptr | br | m | 5 |
oan_br_m_ca1 | oan | br | m | _ |
mmu_br_f_ca1 | mmu | br | f | _ |
hsa_br_f_ca1 | hsa | br | f | _ |
ptr_br_m1_ca1 | ptr | br | m | 1 |
ppa_br_f1_ca1 | ppa | br | f | 1 |
hsa_br_m3_ca1 | hsa | br | m | 3 |
ggo_br_f_ca1 | ggo | br | f | _ |
mmu_br_m1_ca1 | mmu | br | m | 1 |
hsa_br_m2_ca1 | hsa | br | m | 2 |
ptr_br_m4_ca1 | ptr | br | m | 4 |
gga_br_m_ca1 | gga | br | m | _ |
ppa_br_m_ca1 | ppa | br | m | _ |
ppy_br_f_ca1 | ppy | br | f | _ |
gga_br_f_ca1 | gga | br | f | _ |
mml_br_m1_ca1 | mml | br | m | 1 |
hsa_br_m7_ca1 | hsa | br | m | 7 |
mml_br_f_ca1 | mml | br | f | _ |
ppy_br_m_ca1 | ppy | br | m | _ |
mml_br_m2_ca1 | mml | br | m | 2 |